ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ventricular system development (GO:0021591)	7.99123819
2	sperm motility (GO:0030317)	6.77622625
3	axoneme assembly (GO:0035082)	6.69731428
4	regulation of cilium movement (GO:0003352)	6.54926372
5	intraciliary transport (GO:0042073)	6.05860579
6	cilium organization (GO:0044782)	5.69305032
7	cilium assembly (GO:0042384)	5.58573424
8	left/right axis specification (GO:0070986)	5.58304976
9	acrosome reaction (GO:0007340)	4.72155186
10	cilium morphogenesis (GO:0060271)	4.64321525
11	left/right pattern formation (GO:0060972)	4.47296075
12	sperm capacitation (GO:0048240)	4.47261526
13	negative regulation of inclusion body assembly (GO:0090084)	4.45315448
14	cellular component assembly involved in morphogenesis (GO:0010927)	4.44666172
15	multicellular organism reproduction (GO:0032504)	4.34029704
16	spermatid development (GO:0007286)	4.33712172
17	protein localization to cilium (GO:0061512)	4.19836625
18	protein polyglutamylation (GO:0018095)	4.16851839
19	microtubule-based movement (GO:0007018)	4.06666374
20	microtubule depolymerization (GO:0007019)	3.96415707
21	microtubule bundle formation (GO:0001578)	3.91923012
22	regulation of microtubule-based movement (GO:0060632)	3.75162504
23	photoreceptor cell maintenance (GO:0045494)	3.72624129
24	intra-S DNA damage checkpoint (GO:0031573)	3.68976722
25	microtubule polymerization or depolymerization (GO:0031109)	3.68295040
26	one-carbon compound transport (GO:0019755)	3.67787819
27	sperm-egg recognition (GO:0035036)	3.60329129
28	cell projection assembly (GO:0030031)	3.57862211
29	imidazole-containing compound metabolic process (GO:0052803)	3.49801507
30	determination of left/right symmetry (GO:0007368)	3.40292223
31	retinal rod cell development (GO:0046548)	3.40285015
32	regulation of interleukin-5 production (GO:0032674)	3.38357774
33	binding of sperm to zona pellucida (GO:0007339)	3.37226724
34	centriole assembly (GO:0098534)	3.35877530
35	single fertilization (GO:0007338)	3.30335941
36	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.30261458
37	determination of bilateral symmetry (GO:0009855)	3.25432734
38	regulation of interleukin-13 production (GO:0032656)	3.24088553
39	fusion of sperm to egg plasma membrane (GO:0007342)	3.20534605
40	microtubule severing (GO:0051013)	3.20044581
41	gamma-aminobutyric acid transport (GO:0015812)	3.19432543
42	specification of symmetry (GO:0009799)	3.18255953
43	reproduction (GO:0000003)	3.16411086
44	tryptophan catabolic process (GO:0006569)	3.15117181
45	indole-containing compound catabolic process (GO:0042436)	3.15117181
46	indolalkylamine catabolic process (GO:0046218)	3.15117181
47	sex differentiation (GO:0007548)	3.07339629
48	nonmotile primary cilium assembly (GO:0035058)	3.05094017
49	smoothened signaling pathway (GO:0007224)	3.00811726
50	acrosome assembly (GO:0001675)	2.99523263
51	regulation of inclusion body assembly (GO:0090083)	2.99061838
52	cell-cell recognition (GO:0009988)	2.98951976
53	interkinetic nuclear migration (GO:0022027)	2.81639126
54	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.79782023
55	lateral ventricle development (GO:0021670)	2.77702075
56	regulation of cilium assembly (GO:1902017)	2.76514743
57	phosphatidylethanolamine metabolic process (GO:0046337)	2.74712819
58	organic cation transport (GO:0015695)	2.68416644
59	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.67693432
60	organelle assembly (GO:0070925)	2.66156820
61	appendage development (GO:0048736)	2.65950485
62	limb development (GO:0060173)	2.65950485
63	ADP metabolic process (GO:0046031)	2.65222290
64	regulation of establishment of cell polarity (GO:2000114)	2.64748127
65	microtubule-based process (GO:0007017)	2.58166128
66	single strand break repair (GO:0000012)	2.57859812
67	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.57366588
68	coenzyme catabolic process (GO:0009109)	2.55784442
69	cranial nerve morphogenesis (GO:0021602)	2.54144148
70	nucleoside diphosphate phosphorylation (GO:0006165)	2.53551172
71	spermatogenesis (GO:0007283)	2.52746149
72	male gamete generation (GO:0048232)	2.52028647
73	tryptophan metabolic process (GO:0006568)	2.51032442
74	regulation of autophagic vacuole assembly (GO:2000785)	2.48876171
75	male meiosis (GO:0007140)	2.48782875
76	calcium ion-dependent exocytosis (GO:0017156)	2.48524351
77	response to pheromone (GO:0019236)	2.47699175
78	membrane depolarization during action potential (GO:0086010)	2.46986621
79	fertilization (GO:0009566)	2.45286374
80	androgen biosynthetic process (GO:0006702)	2.45011500
81	negative regulation of multicellular organism growth (GO:0040015)	2.44966824
82	positive regulation of catecholamine secretion (GO:0033605)	2.41865872
83	centriole replication (GO:0007099)	2.41379617
84	gamete generation (GO:0007276)	2.36304089
85	regulation of smoothened signaling pathway (GO:0008589)	2.35058444
86	germ cell development (GO:0007281)	2.34666117
87	retinal cone cell development (GO:0046549)	2.34257196
88	regulation of vacuole organization (GO:0044088)	2.33275408
89	plasma membrane fusion (GO:0045026)	2.32360573
90	glomerular epithelial cell development (GO:0072310)	2.32224882
91	auditory behavior (GO:0031223)	2.30462998
92	spermatid nucleus differentiation (GO:0007289)	2.29916733
93	cell wall macromolecule metabolic process (GO:0044036)	2.28982002
94	regulation of action potential (GO:0098900)	2.27238460
95	cilium or flagellum-dependent cell motility (GO:0001539)	15.5139001
96	axonemal dynein complex assembly (GO:0070286)	14.4603353
97	cilium movement (GO:0003341)	13.0237905
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	11.9611826
99	motile cilium assembly (GO:0044458)	11.0509181
100	epithelial cilium movement (GO:0003351)	10.6541217

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.26300720
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.05082702
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.29466715
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.03245981
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.90427953
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.83969983
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.65034806
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.62524949
9	FUS_26573619_Chip-Seq_HEK293_Human	2.41423743
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.35425858
11	VDR_22108803_ChIP-Seq_LS180_Human	2.29686671
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.23565109
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.16656429
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.11353865
15	AR_21572438_ChIP-Seq_LNCaP_Human	2.08810219
16	SMAD4_21799915_ChIP-Seq_A2780_Human	2.07784804
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.05519721
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02981061
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.93556142
20	DROSHA_22980978_ChIP-Seq_HELA_Human	1.91930324
21	STAT3_23295773_ChIP-Seq_U87_Human	1.91213177
22	P300_19829295_ChIP-Seq_ESCs_Human	1.85902133
23	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.84013464
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.81106207
25	CBP_20019798_ChIP-Seq_JUKART_Human	1.81106207
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.80532737
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79998256
28	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.79998256
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.79235258
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.76877531
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.74147049
32	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.69549737
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.67602925
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.67350683
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.66263538
36	TCF4_23295773_ChIP-Seq_U87_Human	1.62659599
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62135420
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.61054459
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56336897
40	AHR_22903824_ChIP-Seq_MCF-7_Human	1.54123862
41	AR_25329375_ChIP-Seq_VCAP_Human	1.50718946
42	RUNX2_22187159_ChIP-Seq_PCA_Human	1.49322540
43	TP53_18474530_ChIP-ChIP_U2OS_Human	1.49297551
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48014844
45	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.45830650
46	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.42988583
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36181792
48	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.35897535
49	ZNF274_21170338_ChIP-Seq_K562_Hela	1.33082529
50	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.31807307
51	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.31379719
52	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.31189783
53	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30373600
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29532411
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.28145506
56	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26182801
57	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.26033745
58	TBL1_22424771_ChIP-Seq_293T_Human	1.25339960
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.24701273
60	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.20858611
61	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.17339306
62	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16670647
63	EWS_26573619_Chip-Seq_HEK293_Human	1.16518910
64	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.14783775
65	ETV1_20927104_ChIP-Seq_GIST48_Human	1.13649945
66	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12147905
67	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11860698
68	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.11275078
69	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10649049
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10462172
71	NFYB_21822215_ChIP-Seq_K562_Human	1.08970887
72	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.06990389
73	PHF8_20622853_ChIP-Seq_HELA_Human	1.06716366
74	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06014268
75	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05496949
76	AR_19668381_ChIP-Seq_PC3_Human	1.05133953
77	RXR_22108803_ChIP-Seq_LS180_Human	1.04723285
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03869227
79	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.03413863
80	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.02767912
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02336276
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02336276
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01859679
84	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01435606
85	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.01278979
86	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.01008410
87	CDX2_22108803_ChIP-Seq_LS180_Human	0.99817035
88	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.99619337
89	TP53_16413492_ChIP-PET_HCT116_Human	0.99516269
90	TP63_23658742_ChIP-Seq_EP156T_Human	0.98623238
91	NFYA_21822215_ChIP-Seq_K562_Human	0.98309641
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.96544731
93	ERA_21632823_ChIP-Seq_H3396_Human	0.96458534
94	SMRT_27268052_Chip-Seq_Bcells_Human	0.95972168
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.95155740
96	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.95000627
97	OCT4_20526341_ChIP-Seq_ESCs_Human	0.94521306
98	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.94491962
99	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.94423032
100	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92258545

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	5.82263500
2	MP0000569_abnormal_digit_pigmentation	5.62654101
3	MP0005410_abnormal_fertilization	4.22835404
4	MP0005623_abnormal_meninges_morphology	3.41000373
5	MP0001984_abnormal_olfaction	3.10422734
6	MP0005423_abnormal_somatic_nervous	2.71890629
7	MP0001485_abnormal_pinna_reflex	2.50923184
8	MP0003698_abnormal_male_reproductive	2.23426080
9	MP0002282_abnormal_trachea_morphology	2.20137932
10	MP0003136_yellow_coat_color	2.16403138
11	MP0009046_muscle_twitch	2.12334423
12	MP0003879_abnormal_hair_cell	2.09161429
13	MP0002132_abnormal_respiratory_system	2.07693429
14	MP0003880_abnormal_central_pattern	2.01386411
15	MP0003011_delayed_dark_adaptation	1.98665479
16	MP0005646_abnormal_pituitary_gland	1.96783834
17	MP0000566_synostosis	1.82739123
18	MP0001529_abnormal_vocalization	1.79793912
19	MP0003878_abnormal_ear_physiology	1.79569177
20	MP0005377_hearing/vestibular/ear_phenot	1.79569177
21	MP0001929_abnormal_gametogenesis	1.71403970
22	MP0004859_abnormal_synaptic_plasticity	1.70707320
23	MP0002638_abnormal_pupillary_reflex	1.69254923
24	MP0005253_abnormal_eye_physiology	1.63808235
25	MP0005551_abnormal_eye_electrophysiolog	1.63483623
26	MP0001968_abnormal_touch/_nociception	1.63133710
27	MP0001486_abnormal_startle_reflex	1.59285383
28	MP0005174_abnormal_tail_pigmentation	1.55140463
29	MP0010386_abnormal_urinary_bladder	1.54209963
30	MP0002160_abnormal_reproductive_system	1.54199376
31	MP0000026_abnormal_inner_ear	1.47815303
32	MP0002736_abnormal_nociception_after	1.45299372
33	MP0004133_heterotaxia	1.39219933
34	MP0004742_abnormal_vestibular_system	1.36611861
35	MP0002734_abnormal_mechanical_nocicepti	1.35100864
36	MP0002572_abnormal_emotion/affect_behav	1.34643930
37	MP0004270_analgesia	1.31741138
38	MP0005499_abnormal_olfactory_system	1.31141590
39	MP0005394_taste/olfaction_phenotype	1.31141590
40	MP0008875_abnormal_xenobiotic_pharmacok	1.30062386
41	MP0003633_abnormal_nervous_system	1.24505342
42	MP0002272_abnormal_nervous_system	1.21152422
43	MP0009745_abnormal_behavioral_response	1.20967290
44	MP0008789_abnormal_olfactory_epithelium	1.20912850
45	MP0004147_increased_porphyrin_level	1.20675955
46	MP0002161_abnormal_fertility/fecundity	1.19182239
47	MP0000383_abnormal_hair_follicle	1.19162937
48	MP0000631_abnormal_neuroendocrine_gland	1.18511295
49	MP0001970_abnormal_pain_threshold	1.15827843
50	MP0002735_abnormal_chemical_nociception	1.12333614
51	MP0001963_abnormal_hearing_physiology	1.11808031
52	MP0001293_anophthalmia	1.10451436
53	MP0003635_abnormal_synaptic_transmissio	1.10334882
54	MP0000427_abnormal_hair_cycle	1.10120168
55	MP0001501_abnormal_sleep_pattern	1.08213143
56	MP0005391_vision/eye_phenotype	1.07258195
57	MP0003252_abnormal_bile_duct	1.05935640
58	MP0003718_maternal_effect	1.02670975
59	MP0002822_catalepsy	1.01808676
60	MP0001905_abnormal_dopamine_level	1.01372035
61	MP0003315_abnormal_perineum_morphology	1.00787570
62	MP0008004_abnormal_stomach_pH	1.00738900
63	MP0003890_abnormal_embryonic-extraembry	1.00114879
64	MP0000778_abnormal_nervous_system	1.00003698
65	MP0004043_abnormal_pH_regulation	0.98280374
66	MP0002249_abnormal_larynx_morphology	0.98101456
67	MP0002067_abnormal_sensory_capabilities	0.98078513
68	MP0005389_reproductive_system_phenotype	0.96287499
69	MP0001986_abnormal_taste_sensitivity	0.96096867
70	MP0002210_abnormal_sex_determination	0.94673127
71	MP0006276_abnormal_autonomic_nervous	0.94219115
72	MP0002229_neurodegeneration	0.93510090
73	MP0003937_abnormal_limbs/digits/tail_de	0.93268235
74	MP0003631_nervous_system_phenotype	0.90807095
75	MP0010030_abnormal_orbit_morphology	0.89874780
76	MP0002063_abnormal_learning/memory/cond	0.88783665
77	MP0000955_abnormal_spinal_cord	0.87118474
78	MP0002064_seizures	0.86622738
79	MP0002233_abnormal_nose_morphology	0.86268890
80	MP0005647_abnormal_sex_gland	0.85049234
81	MP0001145_abnormal_male_reproductive	0.83657852
82	MP0005670_abnormal_white_adipose	0.83149879
83	MP0002882_abnormal_neuron_morphology	0.80375811
84	MP0006072_abnormal_retinal_apoptosis	0.80146994
85	MP0005248_abnormal_Harderian_gland	0.79056646
86	MP0002752_abnormal_somatic_nervous	0.77446963
87	MP0002557_abnormal_social/conspecific_i	0.76191674
88	MP0000653_abnormal_sex_gland	0.75791116
89	MP0001664_abnormal_digestion	0.75584353
90	MP0000049_abnormal_middle_ear	0.75405003
91	MP0002733_abnormal_thermal_nociception	0.75219821
92	MP0002277_abnormal_respiratory_mucosa	0.75154736
93	MP0005195_abnormal_posterior_eye	0.74615651
94	MP0002928_abnormal_bile_duct	0.74442746
95	MP0001502_abnormal_circadian_rhythm	0.74420312
96	MP0003938_abnormal_ear_development	0.71905538
97	MP0001919_abnormal_reproductive_system	0.71076357
98	MP0003119_abnormal_digestive_system	0.70898575
99	MP0002102_abnormal_ear_morphology	0.70497040
100	MP0005395_other_phenotype	0.66398038

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal ciliary motility (HP:0012262)	9.73868935
2	Abnormal respiratory motile cilium physiology (HP:0012261)	9.57779690
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	9.17661746
4	Absent/shortened dynein arms (HP:0200106)	9.17661746
5	Abnormal respiratory motile cilium morphology (HP:0005938)	7.95178750
6	Abnormal respiratory epithelium morphology (HP:0012253)	7.95178750
7	Rhinitis (HP:0012384)	7.88218976
8	Chronic bronchitis (HP:0004469)	5.99814264
9	Nasal polyposis (HP:0100582)	5.64944480
10	Chronic hepatic failure (HP:0100626)	5.45970217
11	Bronchiectasis (HP:0002110)	5.39096207
12	Occipital encephalocele (HP:0002085)	4.95669019
13	Pancreatic fibrosis (HP:0100732)	4.67255917
14	Abnormality of the nasal mucosa (HP:0000433)	4.59847762
15	True hermaphroditism (HP:0010459)	4.23200177
16	Recurrent sinusitis (HP:0011108)	4.16479570
17	Pancreatic cysts (HP:0001737)	3.94866792
18	Tubular atrophy (HP:0000092)	3.62017650
19	Cystic liver disease (HP:0006706)	3.57147531
20	Nephronophthisis (HP:0000090)	3.56656395
21	Abnormal biliary tract physiology (HP:0012439)	3.52143150
22	Bile duct proliferation (HP:0001408)	3.52143150
23	Bronchitis (HP:0012387)	3.47433315
24	Molar tooth sign on MRI (HP:0002419)	3.19462408
25	Abnormality of midbrain morphology (HP:0002418)	3.19462408
26	Recurrent otitis media (HP:0000403)	3.09281190
27	Infertility (HP:0000789)	2.99813114
28	Abnormality of the renal medulla (HP:0100957)	2.99028920
29	Bell-shaped thorax (HP:0001591)	2.88837566
30	Polydipsia (HP:0001959)	2.80863211
31	Abnormal drinking behavior (HP:0030082)	2.80863211
32	Genetic anticipation (HP:0003743)	2.74067694
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.63736294
34	Progressive cerebellar ataxia (HP:0002073)	2.63210377
35	Postaxial foot polydactyly (HP:0001830)	2.57629827
36	Anencephaly (HP:0002323)	2.51559004
37	Tubulointerstitial nephritis (HP:0001970)	2.46701395
38	Congenital hepatic fibrosis (HP:0002612)	2.45275541
39	Sclerocornea (HP:0000647)	2.44797134
40	Medial flaring of the eyebrow (HP:0010747)	2.40974071
41	Chronic sinusitis (HP:0011109)	2.40680198
42	Male pseudohermaphroditism (HP:0000037)	2.39428423
43	Abnormality of the renal cortex (HP:0011035)	2.37426187
44	Gait imbalance (HP:0002141)	2.33530682
45	Congenital primary aphakia (HP:0007707)	2.33350936
46	Bony spicule pigmentary retinopathy (HP:0007737)	2.06164866
47	Genital tract atresia (HP:0001827)	2.04076942
48	Nephrogenic diabetes insipidus (HP:0009806)	2.03184422
49	Abnormality of the hepatic vasculature (HP:0006707)	2.00571058
50	Oculomotor apraxia (HP:0000657)	2.00484521
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.1262674
52	Vaginal atresia (HP:0000148)	1.93520065
53	Polyuria (HP:0000103)	1.91493522
54	Male infertility (HP:0003251)	1.91010662
55	Furrowed tongue (HP:0000221)	1.88522997
56	Postaxial hand polydactyly (HP:0001162)	1.84157771
57	Abnormality of macular pigmentation (HP:0008002)	1.82419237
58	Renal dysplasia (HP:0000110)	1.81662369
59	Intellectual disability, moderate (HP:0002342)	1.80980458
60	Preaxial hand polydactyly (HP:0001177)	1.79955158
61	Poor coordination (HP:0002370)	1.77415129
62	Stage 5 chronic kidney disease (HP:0003774)	1.75456323
63	Anophthalmia (HP:0000528)	1.74126097
64	Abnormal rod and cone electroretinograms (HP:0008323)	1.74032588
65	Recurrent bronchitis (HP:0002837)	1.73921413
66	Abnormal urine output (HP:0012590)	1.71227149
67	Tubulointerstitial abnormality (HP:0001969)	1.68790104
68	Type II lissencephaly (HP:0007260)	1.67433550
69	Action tremor (HP:0002345)	1.66536655
70	Postural instability (HP:0002172)	1.64491596
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.64463428
72	Portal hypertension (HP:0001409)	1.64456295
73	Optic nerve coloboma (HP:0000588)	1.58856079
74	Median cleft lip (HP:0000161)	1.58805539
75	Atonic seizures (HP:0010819)	1.57872943
76	Abnormality of renal excretion (HP:0011036)	1.53003765
77	Narrow forehead (HP:0000341)	1.51949631
78	Focal motor seizures (HP:0011153)	1.49350906
79	Dysmetric saccades (HP:0000641)	1.49074897
80	Gaze-evoked nystagmus (HP:0000640)	1.47333410
81	Retinitis pigmentosa (HP:0000510)	1.45978897
82	Atelectasis (HP:0100750)	1.44389441
83	Hypoplasia of the pons (HP:0012110)	1.44066404
84	Cone-rod dystrophy (HP:0000548)	1.42495082
85	Highly arched eyebrow (HP:0002553)	1.42360597
86	Retinal dysplasia (HP:0007973)	1.41881659
87	Absence seizures (HP:0002121)	1.41498224
88	Focal seizures (HP:0007359)	1.39144313
89	Hyperglycinemia (HP:0002154)	1.37709124
90	Febrile seizures (HP:0002373)	1.36922345
91	Dysdiadochokinesis (HP:0002075)	1.36906518
92	Cerebellar dysplasia (HP:0007033)	1.35183503
93	Prominent nasal bridge (HP:0000426)	1.35050413
94	Supernumerary spleens (HP:0009799)	1.33543802
95	Chronic otitis media (HP:0000389)	1.33041131
96	Aganglionic megacolon (HP:0002251)	1.32635121
97	Hyperventilation (HP:0002883)	1.32406615
98	Abnormality of the pons (HP:0007361)	1.28980165
99	Facial cleft (HP:0002006)	1.26811489
100	Aplasia/Hypoplasia of the lens (HP:0008063)	1.26186197

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	6.30511816
2	PINK1	4.83185226
3	FRK	4.77427702
4	PNCK	4.62851460
5	BMPR1B	2.23669792
6	WNK3	2.19302802
7	PTK2B	2.02920797
8	CASK	1.83760393
9	PRKD3	1.83312612
10	CDK19	1.65688341
11	ZAK	1.65382246
12	MARK3	1.64990708
13	TLK1	1.62856825
14	STK38L	1.61345923
15	BRD4	1.60327222
16	MST4	1.57650512
17	EPHA4	1.51862799
18	MYLK	1.51446452
19	OXSR1	1.49190654
20	STK38	1.46843248
21	MET	1.44380084
22	MAP2K7	1.40101894
23	NTRK2	1.33401119
24	MAP3K4	1.31544513
25	RPS6KA5	1.27494233
26	LATS1	1.26129820
27	PLK4	1.23955643
28	INSRR	1.23490927
29	CAMK1G	1.16193107
30	DYRK3	1.14492356
31	BCR	1.09646760
32	MAPK13	1.05096436
33	SGK223	1.03600320
34	SGK494	1.03600320
35	TNIK	1.03010228
36	WNK4	1.02098048
37	GRK1	0.98632060
38	MAP3K7	0.90583826
39	ACVR1B	0.89342670
40	MUSK	0.87823613
41	PIK3CA	0.87314641
42	ERBB2	0.87268058
43	PLK2	0.85545617
44	ADRBK2	0.85119846
45	NEK2	0.81696353
46	CDK12	0.81474493
47	CAMKK2	0.79337409
48	CDK3	0.73697525
49	NTRK3	0.69943457
50	CSNK1A1L	0.66500925
51	TGFBR1	0.64667977
52	DDR2	0.62891237
53	PAK2	0.62624242
54	CDK5	0.59096166
55	STK11	0.58033180
56	WEE1	0.57765384
57	MARK1	0.56945823
58	CAMK1	0.56535768
59	EPHB1	0.55564586
60	STK39	0.55432794
61	CAMK4	0.55313037
62	ROCK1	0.54533545
63	CSNK1G2	0.54213861
64	RET	0.53235930
65	STK3	0.52716031
66	MAPKAPK5	0.50333911
67	TNK2	0.50193656
68	PRKG1	0.48563440
69	SGK1	0.48205964
70	CAMK2A	0.46992726
71	OBSCN	0.46959234
72	MST1R	0.45384587
73	FGFR2	0.44927977
74	MAP4K2	0.44454994
75	EPHA2	0.44029073
76	PRKCG	0.43375071
77	PRKCQ	0.43222326
78	MAP3K2	0.42764265
79	TIE1	0.42717033
80	DYRK1A	0.42712518
81	SGK2	0.41001102
82	PDPK1	0.40974242
83	FGR	0.39931234
84	RPS6KA3	0.38136567
85	ADRBK1	0.37874064
86	WNK1	0.37197530
87	MARK2	0.36830655
88	MAPK10	0.35009620
89	PDK1	0.34814339
90	TSSK6	0.34283216
91	AKT3	0.33802367
92	CSNK1G1	0.33560314
93	PRKACB	0.33027466
94	CSNK1A1	0.32235249
95	PRKACA	0.32185631
96	DYRK2	0.31226903
97	PKN1	0.29818388
98	NME1	0.29251325
99	MKNK2	0.28774828
100	CCNB1	0.28570505

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.83019152
2	Nicotine addiction_Homo sapiens_hsa05033	2.78274814
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.70916524
4	Olfactory transduction_Homo sapiens_hsa04740	2.69728359
5	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.51142023
6	Chemical carcinogenesis_Homo sapiens_hsa05204	2.36971715
7	Butanoate metabolism_Homo sapiens_hsa00650	2.22959426
8	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.21959759
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.07675942
10	Huntingtons disease_Homo sapiens_hsa05016	2.04803268
11	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.03332260
12	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.00935689
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.00114597
14	Taste transduction_Homo sapiens_hsa04742	1.99198101
15	ABC transporters_Homo sapiens_hsa02010	1.97454788
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.95196919
17	Histidine metabolism_Homo sapiens_hsa00340	1.89524559
18	Alcoholism_Homo sapiens_hsa05034	1.74339955
19	beta-Alanine metabolism_Homo sapiens_hsa00410	1.69859135
20	Retinol metabolism_Homo sapiens_hsa00830	1.69031990
21	Propanoate metabolism_Homo sapiens_hsa00640	1.68428665
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.63235416
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56378637
24	Gap junction_Homo sapiens_hsa04540	1.54628352
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53593507
26	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.42968331
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38373935
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.36963273
29	Morphine addiction_Homo sapiens_hsa05032	1.35018445
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31910989
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.31119480
32	GABAergic synapse_Homo sapiens_hsa04727	1.31058771
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.28939538
34	One carbon pool by folate_Homo sapiens_hsa00670	1.23553145
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.20938862
36	Salivary secretion_Homo sapiens_hsa04970	1.20804171
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.19259773
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.18774331
39	Circadian entrainment_Homo sapiens_hsa04713	1.16943767
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.15864430
41	Fatty acid degradation_Homo sapiens_hsa00071	1.15678128
42	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.15412735
43	Tyrosine metabolism_Homo sapiens_hsa00350	1.11529039
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09551203
45	Peroxisome_Homo sapiens_hsa04146	1.07093438
46	Glutathione metabolism_Homo sapiens_hsa00480	1.04522975
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98153461
48	PPAR signaling pathway_Homo sapiens_hsa03320	0.96577602
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95513215
50	Phototransduction_Homo sapiens_hsa04744	0.93015531
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.89890465
52	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.89226695
53	Caffeine metabolism_Homo sapiens_hsa00232	0.88772198
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85336369
55	Bile secretion_Homo sapiens_hsa04976	0.82754856
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.81882987
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.81504718
58	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.80398369
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78150215
60	Gastric acid secretion_Homo sapiens_hsa04971	0.78087183
61	cAMP signaling pathway_Homo sapiens_hsa04024	0.76503049
62	Renin secretion_Homo sapiens_hsa04924	0.73440841
63	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70277062
64	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69859885
65	Circadian rhythm_Homo sapiens_hsa04710	0.69225072
66	Basal cell carcinoma_Homo sapiens_hsa05217	0.66372736
67	Purine metabolism_Homo sapiens_hsa00230	0.65814814
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63608532
69	Sphingolipid metabolism_Homo sapiens_hsa00600	0.62941546
70	Axon guidance_Homo sapiens_hsa04360	0.58934810
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.56305378
72	Basal transcription factors_Homo sapiens_hsa03022	0.56104448
73	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.54794267
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.53157758
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52518024
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.51898599
77	Insulin secretion_Homo sapiens_hsa04911	0.51767697
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51206393
79	Serotonergic synapse_Homo sapiens_hsa04726	0.50114155
80	Cocaine addiction_Homo sapiens_hsa05030	0.48872501
81	Amphetamine addiction_Homo sapiens_hsa05031	0.48181148
82	Metabolic pathways_Homo sapiens_hsa01100	0.46488691
83	Tight junction_Homo sapiens_hsa04530	0.43942628
84	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.43399674
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.42086241
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41225511
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40385428
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.40284151
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40104164
90	Phagosome_Homo sapiens_hsa04145	0.38840010
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.37852827
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.37073782
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.36952085
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.36247508
95	Pancreatic secretion_Homo sapiens_hsa04972	0.34738732
96	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.34242969
97	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.33650515
98	Lysine degradation_Homo sapiens_hsa00310	0.32569008
99	Sulfur relay system_Homo sapiens_hsa04122	0.31716161
100	Cholinergic synapse_Homo sapiens_hsa04725	0.31459102

SLC9C2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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