SLCO1A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.96446682
2axon ensheathment in central nervous system (GO:0032291)6.96446682
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.14319178
4gamma-aminobutyric acid transport (GO:0015812)4.96964350
5neuronal action potential propagation (GO:0019227)4.82839949
6presynaptic membrane assembly (GO:0097105)4.79701323
7synaptic vesicle maturation (GO:0016188)4.70003196
8presynaptic membrane organization (GO:0097090)4.65439882
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.61769041
10postsynaptic membrane organization (GO:0001941)4.55330289
11neuron cell-cell adhesion (GO:0007158)4.38260715
12negative regulation of synaptic transmission, GABAergic (GO:0032229)4.31576317
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.25651499
14glutamate secretion (GO:0014047)4.22573864
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13965418
16vocalization behavior (GO:0071625)4.10148652
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.09838910
18synaptic vesicle exocytosis (GO:0016079)3.88129655
19synaptic transmission, glutamatergic (GO:0035249)3.87082103
20protein localization to synapse (GO:0035418)3.84667973
21transmission of nerve impulse (GO:0019226)3.82036425
22glutamate receptor signaling pathway (GO:0007215)3.80193938
23neurotransmitter secretion (GO:0007269)3.77271632
24L-amino acid import (GO:0043092)3.69686697
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.69530941
26neurotransmitter-gated ion channel clustering (GO:0072578)3.60145148
27neuronal ion channel clustering (GO:0045161)3.57899078
28cellular potassium ion homeostasis (GO:0030007)3.56468648
29neurotransmitter uptake (GO:0001504)3.52943804
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.52701007
31membrane depolarization during action potential (GO:0086010)3.51480142
32neuron-neuron synaptic transmission (GO:0007270)3.49391400
33serotonin metabolic process (GO:0042428)3.49242987
34startle response (GO:0001964)3.45271548
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.45182752
36locomotory exploration behavior (GO:0035641)3.44150243
37regulation of synaptic vesicle transport (GO:1902803)3.43848077
38regulation of synaptic vesicle exocytosis (GO:2000300)3.43640043
39primary amino compound metabolic process (GO:1901160)3.32793122
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.31286788
41potassium ion import (GO:0010107)3.31125318
42behavioral response to nicotine (GO:0035095)3.26574087
43regulation of neurotransmitter levels (GO:0001505)3.25575171
44auditory behavior (GO:0031223)3.24171621
45neurotransmitter transport (GO:0006836)3.21852106
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19259260
47neuromuscular synaptic transmission (GO:0007274)3.17521280
48C4-dicarboxylate transport (GO:0015740)3.16009622
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14031952
50proline transport (GO:0015824)3.13595527
51adult walking behavior (GO:0007628)3.12802276
52exploration behavior (GO:0035640)3.10449329
53regulation of neuronal synaptic plasticity (GO:0048168)3.10282680
54neuronal action potential (GO:0019228)3.07954973
55regulation of voltage-gated calcium channel activity (GO:1901385)3.07498988
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07142718
57phosphorelay signal transduction system (GO:0000160)3.06899967
58amino acid import (GO:0043090)3.03994778
59dendritic spine morphogenesis (GO:0060997)3.02090489
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00837587
61cerebellar Purkinje cell differentiation (GO:0021702)3.00674261
62cerebellar granule cell differentiation (GO:0021707)3.00625586
63regulation of excitatory postsynaptic membrane potential (GO:0060079)2.99508370
64positive regulation of dendritic spine development (GO:0060999)2.98263493
65regulation of synaptic transmission, glutamatergic (GO:0051966)2.96999041
66positive regulation of membrane potential (GO:0045838)2.94966375
67membrane depolarization (GO:0051899)2.94415290
68positive regulation of synapse maturation (GO:0090129)2.93320214
69potassium ion homeostasis (GO:0055075)2.89699102
70regulation of glutamate receptor signaling pathway (GO:1900449)2.89349569
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87365461
72glycerophospholipid catabolic process (GO:0046475)2.86850591
73regulation of postsynaptic membrane potential (GO:0060078)2.86363405
74response to pheromone (GO:0019236)2.85948754
75long-chain fatty acid biosynthetic process (GO:0042759)2.85338270
76synaptic transmission (GO:0007268)2.84584158
77cyclic nucleotide catabolic process (GO:0009214)2.84377389
78regulation of neurotransmitter transport (GO:0051588)2.80357999
79acidic amino acid transport (GO:0015800)2.79200808
80mechanosensory behavior (GO:0007638)2.78217965
81positive regulation of potassium ion transmembrane transport (GO:1901381)2.78010190
82regulation of neurotransmitter secretion (GO:0046928)2.77646736
83protein polyglutamylation (GO:0018095)2.75459164
84regulation of neurotransmitter uptake (GO:0051580)2.75048762
85synaptic vesicle endocytosis (GO:0048488)2.74610902
86fucose catabolic process (GO:0019317)2.74480121
87L-fucose metabolic process (GO:0042354)2.74480121
88L-fucose catabolic process (GO:0042355)2.74480121
89myelination (GO:0042552)2.72898857
90regulation of synapse maturation (GO:0090128)2.72808925
91cellular potassium ion transport (GO:0071804)2.72601349
92potassium ion transmembrane transport (GO:0071805)2.72601349
93regulation of dendritic spine development (GO:0060998)2.70907619
94regulation of long-term neuronal synaptic plasticity (GO:0048169)2.70254061
95regulation of synaptic transmission, GABAergic (GO:0032228)2.68844174
96regulation of synapse structural plasticity (GO:0051823)2.67389197
97regulation of dendritic spine morphogenesis (GO:0061001)2.65635660
98adult behavior (GO:0030534)2.63885111
99axon ensheathment (GO:0008366)2.61911066
100ensheathment of neurons (GO:0007272)2.61911066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.58824134
2GBX2_23144817_ChIP-Seq_PC3_Human3.58130504
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88167448
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61854358
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57355013
6REST_21632747_ChIP-Seq_MESCs_Mouse2.41698040
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30565636
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29440049
9TAF15_26573619_Chip-Seq_HEK293_Human2.20109759
10VDR_22108803_ChIP-Seq_LS180_Human2.15468073
11ZNF274_21170338_ChIP-Seq_K562_Hela2.14751699
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13596944
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13204066
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06263166
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05235692
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04810187
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03071547
18DROSHA_22980978_ChIP-Seq_HELA_Human1.98938857
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98049506
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96395047
21P300_19829295_ChIP-Seq_ESCs_Human1.94993328
22IGF1R_20145208_ChIP-Seq_DFB_Human1.93580278
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86636321
24SMAD4_21799915_ChIP-Seq_A2780_Human1.76932055
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.74260322
26* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72735920
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.71494362
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70797703
29FUS_26573619_Chip-Seq_HEK293_Human1.66691253
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65645662
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.64515528
32AR_21572438_ChIP-Seq_LNCaP_Human1.62168148
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62091169
34* STAT3_23295773_ChIP-Seq_U87_Human1.61425316
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60436232
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.57035374
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.56798084
38RNF2_27304074_Chip-Seq_NSC_Mouse1.56630748
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56270568
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.56169733
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56002864
42* TCF4_23295773_ChIP-Seq_U87_Human1.54052729
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53558266
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.53513076
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.53239970
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52703896
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.52161982
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51353862
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51053853
50EWS_26573619_Chip-Seq_HEK293_Human1.50886429
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46962265
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44576921
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42561779
54AR_25329375_ChIP-Seq_VCAP_Human1.42345061
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42252489
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42252489
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42036155
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41733692
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34560689
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34560689
61ER_23166858_ChIP-Seq_MCF-7_Human1.33546373
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.32228124
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28797498
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27461910
65BCAT_22108803_ChIP-Seq_LS180_Human1.27139454
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25927033
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.25136587
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23424787
69RUNX2_22187159_ChIP-Seq_PCA_Human1.22505424
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.22412249
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21805207
72TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20963765
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20513181
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19766447
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18609956
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17721671
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16391062
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.15040132
79* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13621744
80* CBP_20019798_ChIP-Seq_JUKART_Human1.13621744
81P53_22387025_ChIP-Seq_ESCs_Mouse1.10697369
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10009313
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09799478
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09613649
85TCF4_22108803_ChIP-Seq_LS180_Human1.09275414
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.08803262
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08761621
88AR_19668381_ChIP-Seq_PC3_Human1.08228299
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07809239
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06736409
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.05567977
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.05323823
93NANOG_19829295_ChIP-Seq_ESCs_Human1.05250035
94SOX2_19829295_ChIP-Seq_ESCs_Human1.05250035
95KDM2B_26808549_Chip-Seq_REH_Human1.04311767
96TP53_16413492_ChIP-PET_HCT116_Human1.03718578
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03641515
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03224266
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01444984
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.01096373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.95448897
2MP0004859_abnormal_synaptic_plasticity3.86884049
3MP0004270_analgesia3.36202495
4MP0005423_abnormal_somatic_nervous3.18292821
5MP0002064_seizures3.14166353
6MP0003635_abnormal_synaptic_transmissio3.13042772
7MP0001486_abnormal_startle_reflex3.12666963
8MP0009046_muscle_twitch3.11357668
9MP0009745_abnormal_behavioral_response3.10186207
10MP0002272_abnormal_nervous_system2.98305507
11MP0001968_abnormal_touch/_nociception2.84489560
12MP0004885_abnormal_endolymph2.52764509
13MP0002063_abnormal_learning/memory/cond2.52339649
14MP0002735_abnormal_chemical_nociception2.41882680
15MP0002734_abnormal_mechanical_nocicepti2.41608121
16MP0002572_abnormal_emotion/affect_behav2.34896102
17MP0001501_abnormal_sleep_pattern2.13603824
18MP0003787_abnormal_imprinting2.10915678
19MP0005646_abnormal_pituitary_gland2.07857353
20MP0002736_abnormal_nociception_after2.06506758
21MP0001984_abnormal_olfaction1.98002090
22MP0005551_abnormal_eye_electrophysiolog1.92805776
23MP0002067_abnormal_sensory_capabilities1.89252900
24MP0003690_abnormal_glial_cell1.86888785
25MP0004742_abnormal_vestibular_system1.85341320
26MP0001970_abnormal_pain_threshold1.83552513
27MP0008877_abnormal_DNA_methylation1.82018568
28MP0002733_abnormal_thermal_nociception1.75266872
29MP0001485_abnormal_pinna_reflex1.74488589
30MP0000778_abnormal_nervous_system1.73435934
31MP0000920_abnormal_myelination1.73308018
32MP0005386_behavior/neurological_phenoty1.69199790
33MP0004924_abnormal_behavior1.69199790
34MP0006276_abnormal_autonomic_nervous1.68929137
35MP0002557_abnormal_social/conspecific_i1.65736423
36MP0008569_lethality_at_weaning1.64634710
37MP0003633_abnormal_nervous_system1.61594780
38MP0001529_abnormal_vocalization1.58594811
39MP0000569_abnormal_digit_pigmentation1.51615432
40MP0001986_abnormal_taste_sensitivity1.51590709
41MP0004147_increased_porphyrin_level1.51572776
42MP0004142_abnormal_muscle_tone1.50758871
43MP0001905_abnormal_dopamine_level1.43198284
44MP0002229_neurodegeneration1.40756011
45MP0003136_yellow_coat_color1.39616638
46MP0005645_abnormal_hypothalamus_physiol1.39223075
47MP0002882_abnormal_neuron_morphology1.38413823
48MP0003631_nervous_system_phenotype1.36850801
49MP0000955_abnormal_spinal_cord1.36321223
50MP0008872_abnormal_physiological_respon1.33154077
51MP0001440_abnormal_grooming_behavior1.31780097
52MP0002066_abnormal_motor_capabilities/c1.27928579
53MP0003879_abnormal_hair_cell1.27409526
54MP0002638_abnormal_pupillary_reflex1.24325663
55MP0000631_abnormal_neuroendocrine_gland1.20928510
56MP0005253_abnormal_eye_physiology1.20759286
57MP0009780_abnormal_chondrocyte_physiolo1.20342876
58MP0003632_abnormal_nervous_system1.19894331
59MP0001963_abnormal_hearing_physiology1.19406837
60MP0002184_abnormal_innervation1.17232971
61MP0004811_abnormal_neuron_physiology1.16752032
62MP0003195_calcinosis1.15938505
63MP0001502_abnormal_circadian_rhythm1.15628997
64MP0003122_maternal_imprinting1.10639960
65MP0002752_abnormal_somatic_nervous1.05131298
66MP0002102_abnormal_ear_morphology1.03808532
67MP0005167_abnormal_blood-brain_barrier1.03380102
68MP0003329_amyloid_beta_deposits1.01737755
69MP0004043_abnormal_pH_regulation1.01223910
70MP0004133_heterotaxia1.00534062
71MP0002152_abnormal_brain_morphology0.99133275
72MP0001177_atelectasis0.97998736
73MP0002822_catalepsy0.96258954
74MP0006072_abnormal_retinal_apoptosis0.93981448
75MP0001299_abnormal_eye_distance/0.90254156
76MP0010386_abnormal_urinary_bladder0.88373886
77MP0002653_abnormal_ependyma_morphology0.85501580
78MP0004145_abnormal_muscle_electrophysio0.83394590
79MP0003121_genomic_imprinting0.82714808
80MP0002234_abnormal_pharynx_morphology0.82344915
81MP0000026_abnormal_inner_ear0.82143529
82MP0000566_synostosis0.81403627
83MP0000383_abnormal_hair_follicle0.78932930
84MP0003137_abnormal_impulse_conducting0.78005316
85MP0005195_abnormal_posterior_eye0.77334438
86MP0000427_abnormal_hair_cycle0.77222448
87MP0005187_abnormal_penis_morphology0.77097899
88MP0002909_abnormal_adrenal_gland0.76570398
89MP0003634_abnormal_glial_cell0.76550276
90MP0004215_abnormal_myocardial_fiber0.76334265
91MP0002069_abnormal_eating/drinking_beha0.73299774
92MP0005171_absent_coat_pigmentation0.72290351
93MP0003119_abnormal_digestive_system0.68655625
94MP0003878_abnormal_ear_physiology0.62277743
95MP0005377_hearing/vestibular/ear_phenot0.62277743
96MP0003698_abnormal_male_reproductive0.61712040
97MP0003283_abnormal_digestive_organ0.61500552
98MP0008875_abnormal_xenobiotic_pharmacok0.60823125
99MP0002751_abnormal_autonomic_nervous0.60641346
100MP0001188_hyperpigmentation0.60204158

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.50775943
2Focal seizures (HP:0007359)4.62202873
3Febrile seizures (HP:0002373)4.60399779
4Myokymia (HP:0002411)4.32284174
5Hyperventilation (HP:0002883)4.05433007
6Epileptic encephalopathy (HP:0200134)4.03117347
7Progressive cerebellar ataxia (HP:0002073)3.83987973
8Atonic seizures (HP:0010819)3.83538941
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.76083311
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.76083311
11Action tremor (HP:0002345)3.64690625
12Abnormality of the corticospinal tract (HP:0002492)3.33053892
13Dialeptic seizures (HP:0011146)3.27729276
14Gaze-evoked nystagmus (HP:0000640)3.26968718
15Generalized tonic-clonic seizures (HP:0002069)3.20476272
16Hemiparesis (HP:0001269)3.15515924
17Broad-based gait (HP:0002136)3.12984115
18Limb dystonia (HP:0002451)3.11217579
19Diplopia (HP:0000651)3.05993595
20Abnormality of binocular vision (HP:0011514)3.05993595
21Absence seizures (HP:0002121)2.98223927
22Pancreatic cysts (HP:0001737)2.67664833
23True hermaphroditism (HP:0010459)2.63509445
24Genetic anticipation (HP:0003743)2.62770860
25Spastic gait (HP:0002064)2.61281883
26Absent speech (HP:0001344)2.60482899
27Pancreatic fibrosis (HP:0100732)2.52831591
28Medial flaring of the eyebrow (HP:0010747)2.52553323
29Drooling (HP:0002307)2.51364280
30Abnormal eating behavior (HP:0100738)2.51155066
31Nephronophthisis (HP:0000090)2.51007934
32Gait imbalance (HP:0002141)2.48875929
33Protruding tongue (HP:0010808)2.48842135
34Urinary bladder sphincter dysfunction (HP:0002839)2.48467873
35Abnormality of midbrain morphology (HP:0002418)2.47311375
36Molar tooth sign on MRI (HP:0002419)2.47311375
37Epileptiform EEG discharges (HP:0011182)2.43435486
38Morphological abnormality of the pyramidal tract (HP:0002062)2.42378760
39Hemiplegia (HP:0002301)2.39519317
40Inability to walk (HP:0002540)2.36992645
41Congenital stationary night blindness (HP:0007642)2.30804425
42Cerebral hypomyelination (HP:0006808)2.30661395
43Status epilepticus (HP:0002133)2.30531609
44Excessive salivation (HP:0003781)2.24491344
45Ankle clonus (HP:0011448)2.22930319
46Postural instability (HP:0002172)2.21827399
47EEG with generalized epileptiform discharges (HP:0011198)2.20843976
48Type II lissencephaly (HP:0007260)2.20092810
49Increased circulating renin level (HP:0000848)2.19624015
50Polyphagia (HP:0002591)2.19161936
51Spastic tetraparesis (HP:0001285)2.19079647
52Dysdiadochokinesis (HP:0002075)2.18692542
53Hypsarrhythmia (HP:0002521)2.13288154
54Polydipsia (HP:0001959)2.13266422
55Abnormal drinking behavior (HP:0030082)2.13266422
56Abnormality of the labia minora (HP:0012880)2.12776795
57Abnormality of the renal medulla (HP:0100957)2.09432192
58Congenital primary aphakia (HP:0007707)2.06700403
59Impaired vibration sensation in the lower limbs (HP:0002166)2.03694327
60Clumsiness (HP:0002312)2.01477141
61Genital tract atresia (HP:0001827)2.00982461
62Vaginal atresia (HP:0000148)1.96808638
63Dysmetria (HP:0001310)1.96580006
64Abnormality of the renal cortex (HP:0011035)1.96202297
65Poor eye contact (HP:0000817)1.95597211
66Nephrogenic diabetes insipidus (HP:0009806)1.94462497
67Intention tremor (HP:0002080)1.94399467
68Anxiety (HP:0000739)1.93827853
69Lower limb muscle weakness (HP:0007340)1.92325392
70Abolished electroretinogram (ERG) (HP:0000550)1.91333791
71Hypomagnesemia (HP:0002917)1.91254038
72Progressive inability to walk (HP:0002505)1.90570871
73CNS hypomyelination (HP:0003429)1.90301084
74Megalencephaly (HP:0001355)1.88182583
75Scanning speech (HP:0002168)1.86518007
76Attenuation of retinal blood vessels (HP:0007843)1.85053959
77Decreased central vision (HP:0007663)1.85016584
78Cerebellar dysplasia (HP:0007033)1.83936437
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82822832
80Urinary urgency (HP:0000012)1.81998989
81Cystic liver disease (HP:0006706)1.81439693
82Abnormality of alanine metabolism (HP:0010916)1.80559679
83Hyperalaninemia (HP:0003348)1.80559679
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80559679
85Metabolic alkalosis (HP:0200114)1.80454342
86Impaired smooth pursuit (HP:0007772)1.80051709
87Optic nerve hypoplasia (HP:0000609)1.79956817
88Split foot (HP:0001839)1.79549889
89Stomach cancer (HP:0012126)1.78403077
90Spastic tetraplegia (HP:0002510)1.78396949
91Birth length less than 3rd percentile (HP:0003561)1.76324992
92Visual hallucinations (HP:0002367)1.74285210
93Specific learning disability (HP:0001328)1.72901907
94Pheochromocytoma (HP:0002666)1.72456405
95Alacrima (HP:0000522)1.72263302
96Chronic hepatic failure (HP:0100626)1.70638309
97Sleep apnea (HP:0010535)1.68709257
98Neurofibrillary tangles (HP:0002185)1.67931122
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.66589950
100Abnormal respiratory epithelium morphology (HP:0012253)1.65762573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.80763541
2FRK3.70397945
3NTRK33.49521729
4MARK13.45255658
5EPHA43.03877874
6DAPK22.59497589
7NTRK22.56798163
8UHMK12.51417016
9PINK12.35757246
10PNCK2.19096184
11MAPK132.13525996
12MAP3K42.11491409
13OXSR11.87069008
14WNK31.86731258
15FGFR21.84477607
16PAK61.78884437
17BMPR1B1.70433600
18MINK11.67233094
19TNIK1.66815159
20ADRBK21.60570967
21PRKCG1.58043075
22STK391.57892741
23INSRR1.50311660
24PLK21.42953266
25MAP2K71.36984536
26GRK11.36699466
27WNK41.34959436
28ACVR1B1.28013754
29TLK11.26703996
30MAP4K21.25802596
31PHKG11.25262162
32PHKG21.25262162
33PAK31.24143450
34CAMK2B1.22289223
35MAPKAPK51.22126964
36PKN11.16609093
37CAMKK21.13444652
38CDK191.10806983
39CAMK2A1.09178749
40CAMKK11.09140230
41SGK4941.08617114
42SGK2231.08617114
43CDK51.04876891
44MAP3K91.01121529
45SGK20.99543742
46TAOK30.97491140
47CAMK10.95848827
48ZAK0.93620264
49PRKD30.90520872
50STK110.89312235
51PRKCE0.87725294
52TYRO30.85709783
53PIK3CA0.80090768
54DYRK1A0.77412689
55NUAK10.76309967
56CSNK1G20.75857300
57NTRK10.75162782
58MAP2K40.73258341
59MKNK20.72034860
60CAMK2D0.70524363
61SGK10.69744334
62CAMK2G0.68521665
63DAPK10.66293130
64GRK50.63262309
65WNK10.62954074
66PRKCH0.57739344
67ADRBK10.55335705
68DYRK20.54397388
69PRKG10.54314639
70PTK2B0.53879494
71SIK20.53754110
72RPS6KA30.53478594
73STK38L0.52036948
74TSSK60.51350225
75CSNK1G10.50891807
76MAPK100.49847153
77PRKACA0.48724085
78BMPR20.47753661
79CSNK1A10.45431404
80STK380.45269538
81TRIM280.44840793
82PRKCZ0.44692703
83CSNK1D0.44064293
84PRKCA0.43571837
85CAMK1G0.43257533
86CAMK40.42532077
87CSNK1G30.40931709
88AKT30.40910538
89SGK30.39334762
90CSNK1A1L0.39087417
91CDK180.38659759
92CDK150.38517736
93ERBB20.38257469
94MAP3K120.36667525
95MAPK150.35354337
96PRKCB0.34899547
97PRKCQ0.34711200
98LIMK10.33479302
99CDK11A0.31838954
100NEK60.30425158

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.58259275
2Morphine addiction_Homo sapiens_hsa050322.83891164
3GABAergic synapse_Homo sapiens_hsa047272.81847702
4Circadian entrainment_Homo sapiens_hsa047132.69122599
5Glutamatergic synapse_Homo sapiens_hsa047242.64630513
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55485273
7Synaptic vesicle cycle_Homo sapiens_hsa047212.49762197
8Insulin secretion_Homo sapiens_hsa049112.41307217
9Amphetamine addiction_Homo sapiens_hsa050312.18798968
10Taste transduction_Homo sapiens_hsa047422.08301883
11Phototransduction_Homo sapiens_hsa047442.07620636
12Dopaminergic synapse_Homo sapiens_hsa047281.91140099
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82166951
14Histidine metabolism_Homo sapiens_hsa003401.79180435
15Salivary secretion_Homo sapiens_hsa049701.74126683
16Gastric acid secretion_Homo sapiens_hsa049711.73071975
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72565172
18Cocaine addiction_Homo sapiens_hsa050301.71507802
19Butanoate metabolism_Homo sapiens_hsa006501.71469868
20Olfactory transduction_Homo sapiens_hsa047401.64248460
21Nitrogen metabolism_Homo sapiens_hsa009101.58658647
22Serotonergic synapse_Homo sapiens_hsa047261.54034830
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52874427
24Long-term potentiation_Homo sapiens_hsa047201.49779529
25Calcium signaling pathway_Homo sapiens_hsa040201.44379471
26beta-Alanine metabolism_Homo sapiens_hsa004101.44273230
27Linoleic acid metabolism_Homo sapiens_hsa005911.41727400
28Ether lipid metabolism_Homo sapiens_hsa005651.40305402
29Cholinergic synapse_Homo sapiens_hsa047251.35678806
30Renin secretion_Homo sapiens_hsa049241.28653904
31cAMP signaling pathway_Homo sapiens_hsa040241.26173590
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26117630
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25476242
34Cardiac muscle contraction_Homo sapiens_hsa042601.24991175
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.23749572
36Long-term depression_Homo sapiens_hsa047301.20674687
37Oxytocin signaling pathway_Homo sapiens_hsa049211.16233979
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15615731
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15543509
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13644988
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09161037
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06634135
43Tryptophan metabolism_Homo sapiens_hsa003801.05532222
44ABC transporters_Homo sapiens_hsa020101.05202769
45Oxidative phosphorylation_Homo sapiens_hsa001901.01026499
46Collecting duct acid secretion_Homo sapiens_hsa049661.00877510
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.94779720
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92054667
49Vitamin B6 metabolism_Homo sapiens_hsa007500.90865935
50Pancreatic secretion_Homo sapiens_hsa049720.89350480
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87253744
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84404515
53* Bile secretion_Homo sapiens_hsa049760.83187694
54Propanoate metabolism_Homo sapiens_hsa006400.83061027
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.79233904
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78044581
57Arginine and proline metabolism_Homo sapiens_hsa003300.78020136
58Circadian rhythm_Homo sapiens_hsa047100.75427620
59Parkinsons disease_Homo sapiens_hsa050120.70429154
60Caffeine metabolism_Homo sapiens_hsa002320.70098682
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69684891
62Ovarian steroidogenesis_Homo sapiens_hsa049130.69460030
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68277816
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67621249
65Alzheimers disease_Homo sapiens_hsa050100.66991102
66Thyroid hormone synthesis_Homo sapiens_hsa049180.65142476
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64200173
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63856499
69Ras signaling pathway_Homo sapiens_hsa040140.63735900
70Dorso-ventral axis formation_Homo sapiens_hsa043200.62697022
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62321236
72Mineral absorption_Homo sapiens_hsa049780.61193389
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57934829
74Estrogen signaling pathway_Homo sapiens_hsa049150.57920478
75Axon guidance_Homo sapiens_hsa043600.57733138
76Regulation of autophagy_Homo sapiens_hsa041400.56054365
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52922651
78Peroxisome_Homo sapiens_hsa041460.51787367
79Oocyte meiosis_Homo sapiens_hsa041140.51530927
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50239744
81Gap junction_Homo sapiens_hsa045400.49739448
82Fatty acid biosynthesis_Homo sapiens_hsa000610.48191200
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.47506494
84Type II diabetes mellitus_Homo sapiens_hsa049300.47410803
85Melanogenesis_Homo sapiens_hsa049160.46313969
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45887072
87Glycerolipid metabolism_Homo sapiens_hsa005610.44409457
88MAPK signaling pathway_Homo sapiens_hsa040100.43830349
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.43007661
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41944858
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40557640
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39443169
93Huntingtons disease_Homo sapiens_hsa050160.35917369
94Rap1 signaling pathway_Homo sapiens_hsa040150.35632213
95Chemical carcinogenesis_Homo sapiens_hsa052040.35287994
96Arachidonic acid metabolism_Homo sapiens_hsa005900.34787868
97Arginine biosynthesis_Homo sapiens_hsa002200.33784081
98GnRH signaling pathway_Homo sapiens_hsa049120.33405969
99Retinol metabolism_Homo sapiens_hsa008300.33094382
100Hippo signaling pathway_Homo sapiens_hsa043900.33064000

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