SLCO1B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug catabolic process (GO:0042737)9.70396468
2omega-hydroxylase P450 pathway (GO:0097267)9.10217898
3epoxygenase P450 pathway (GO:0019373)9.04125785
4regulation of fibrinolysis (GO:0051917)8.48901561
5negative regulation of fibrinolysis (GO:0051918)8.37332142
6complement activation, alternative pathway (GO:0006957)8.32875202
7glyoxylate metabolic process (GO:0046487)8.02256070
8regulation of protein activation cascade (GO:2000257)7.68726484
9L-phenylalanine catabolic process (GO:0006559)7.62603817
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62603817
11regulation of complement activation (GO:0030449)7.20498464
12cellular glucuronidation (GO:0052695)7.02366849
13L-phenylalanine metabolic process (GO:0006558)6.99580895
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.99580895
15urea metabolic process (GO:0019627)6.99540266
16ethanol oxidation (GO:0006069)6.81848195
17fibrinolysis (GO:0042730)6.74333562
18glucuronate metabolic process (GO:0019585)6.67375814
19uronic acid metabolic process (GO:0006063)6.67375814
20drug metabolic process (GO:0017144)6.46337359
21nitrogen cycle metabolic process (GO:0071941)6.35656893
22oxidative demethylation (GO:0070989)6.29647151
23bile acid biosynthetic process (GO:0006699)6.27439273
24peptidyl-glutamic acid carboxylation (GO:0017187)6.20623484
25protein carboxylation (GO:0018214)6.20623484
26blood coagulation, intrinsic pathway (GO:0007597)5.95061707
27aromatic amino acid family catabolic process (GO:0009074)5.77550959
28urea cycle (GO:0000050)5.74613366
29serine family amino acid catabolic process (GO:0009071)5.57453418
30negative regulation of sterol transport (GO:0032372)5.50901175
31negative regulation of cholesterol transport (GO:0032375)5.50901175
32ethanol metabolic process (GO:0006067)5.49050862
33phenylpropanoid metabolic process (GO:0009698)5.28860043
34* bile acid metabolic process (GO:0008206)5.26555785
35regulation of triglyceride catabolic process (GO:0010896)5.13794457
36regulation of plasminogen activation (GO:0010755)5.13311606
37glycine metabolic process (GO:0006544)5.11391592
38protein activation cascade (GO:0072376)5.04272506
39negative regulation of hemostasis (GO:1900047)4.94556185
40negative regulation of blood coagulation (GO:0030195)4.94556185
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.81121029
42imidazole-containing compound metabolic process (GO:0052803)4.77631109
43S-adenosylmethionine metabolic process (GO:0046500)4.74282405
44complement activation (GO:0006956)4.73020799
45* bile acid and bile salt transport (GO:0015721)4.67852409
46complement activation, classical pathway (GO:0006958)4.61374786
47amino-acid betaine metabolic process (GO:0006577)4.57836395
48regulation of humoral immune response (GO:0002920)4.55229066
49negative regulation of protein activation cascade (GO:2000258)4.52576210
50negative regulation of coagulation (GO:0050819)4.49140242
51triglyceride homeostasis (GO:0070328)4.46853014
52acylglycerol homeostasis (GO:0055090)4.46853014
53negative regulation of wound healing (GO:0061045)4.44312403
54alkaloid metabolic process (GO:0009820)4.40608016
55tyrosine metabolic process (GO:0006570)4.33977000
56acute-phase response (GO:0006953)4.33445560
57hormone catabolic process (GO:0042447)4.31659196
58positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.28401112
59disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.26205153
60killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.26205153
61opsonization (GO:0008228)4.22012470
62positive regulation of hemostasis (GO:1900048)4.20497492
63positive regulation of blood coagulation (GO:0030194)4.20497492
64phospholipid efflux (GO:0033700)4.14228036
65cytolysis (GO:0019835)4.13135518
66tryptophan catabolic process (GO:0006569)4.13059529
67indole-containing compound catabolic process (GO:0042436)4.13059529
68indolalkylamine catabolic process (GO:0046218)4.13059529
69daunorubicin metabolic process (GO:0044597)4.11409350
70polyketide metabolic process (GO:0030638)4.11409350
71doxorubicin metabolic process (GO:0044598)4.11409350
72serine family amino acid metabolic process (GO:0009069)4.06226923
73fat-soluble vitamin biosynthetic process (GO:0042362)4.04382138
74positive regulation of lipoprotein lipase activity (GO:0051006)3.98428576
75positive regulation of triglyceride lipase activity (GO:0061365)3.98428576
76heme transport (GO:0015886)3.96090892
77flavonoid metabolic process (GO:0009812)3.95772102
78arginine metabolic process (GO:0006525)3.93644338
79plasma lipoprotein particle remodeling (GO:0034369)3.90645746
80protein-lipid complex remodeling (GO:0034368)3.90645746
81macromolecular complex remodeling (GO:0034367)3.90645746
82cholesterol efflux (GO:0033344)3.90223441
83alpha-amino acid catabolic process (GO:1901606)3.90117502
84positive regulation of coagulation (GO:0050820)3.89895192
85intestinal cholesterol absorption (GO:0030299)3.89048454
86glutamate metabolic process (GO:0006536)3.88531322
87negative regulation of lipase activity (GO:0060192)3.87061643
88high-density lipoprotein particle remodeling (GO:0034375)3.81384747
89response to mercury ion (GO:0046689)3.79841400
90aromatic amino acid family metabolic process (GO:0009072)3.75207359
91aminoglycoside antibiotic metabolic process (GO:0030647)3.70309718
92xenobiotic metabolic process (GO:0006805)3.69219535
93primary alcohol catabolic process (GO:0034310)3.63765932
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62834212
95regulation of cholesterol esterification (GO:0010872)3.59453172
96negative regulation of complement activation (GO:0045916)3.59302693
97cellular ketone body metabolic process (GO:0046950)3.54484102
98steroid catabolic process (GO:0006706)3.50117059
99serine family amino acid biosynthetic process (GO:0009070)3.49147149
100exogenous drug catabolic process (GO:0042738)10.5590168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse7.11065392
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.05724347
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.89039300
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.80595953
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.23691643
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.85313978
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.31460000
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.29506645
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06279951
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67513521
11HNF4A_19822575_ChIP-Seq_HepG2_Human2.15723775
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.13175443
13FOXA2_19822575_ChIP-Seq_HepG2_Human2.10800046
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.07457309
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3095197
16HTT_18923047_ChIP-ChIP_STHdh_Human1.88753902
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.68383147
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61762483
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42148079
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21954906
21AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19656762
22* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15869925
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10723113
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04828850
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01382314
26HNFA_21074721_ChIP-Seq_CACO-2_Human0.97382566
27TRIM28_21343339_ChIP-Seq_HEK293_Human0.97028236
28IRF1_19129219_ChIP-ChIP_H3396_Human0.96390577
29CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95636325
30CBP_21632823_ChIP-Seq_H3396_Human0.95427386
31PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95153446
32RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94536141
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93431861
34IRF8_22096565_ChIP-ChIP_GC-B_Human0.91969851
35NFE2_27457419_Chip-Seq_LIVER_Mouse0.91101621
36GATA4_25053715_ChIP-Seq_YYC3_Human0.90189698
37BCAT_22108803_ChIP-Seq_LS180_Human0.89595778
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88901149
39* PHF8_20622853_ChIP-Seq_HELA_Human0.86925991
40PIAS1_25552417_ChIP-Seq_VCAP_Human0.85841655
41FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84987450
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84545484
43FOXA1_25552417_ChIP-Seq_VCAP_Human0.82750769
44KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81123881
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80700043
46EZH2_27294783_Chip-Seq_NPCs_Mouse0.80657512
47GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79720740
48CEBPB_22108803_ChIP-Seq_LS180_Human0.77289083
49TP53_18474530_ChIP-ChIP_U2OS_Human0.76980042
50AR_20517297_ChIP-Seq_VCAP_Human0.76573463
51* NFYA_21822215_ChIP-Seq_K562_Human0.76198051
52GATA6_21074721_ChIP-Seq_CACO-2_Human0.75284154
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74778909
54POU3F2_20337985_ChIP-ChIP_501MEL_Human0.73190899
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72204433
56SOX2_21211035_ChIP-Seq_LN229_Human0.71625067
57CDX2_20551321_ChIP-Seq_CACO-2_Human0.71344415
58SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69503763
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67594664
60SUZ12_27294783_Chip-Seq_NPCs_Mouse0.67418799
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.67249505
62CBX2_22325352_ChIP-Seq_293T-Rex_Human0.67241575
63SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66951301
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66314758
65ER_23166858_ChIP-Seq_MCF-7_Human0.65793371
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.64047417
67GATA1_22025678_ChIP-Seq_K562_Human0.63796960
68CRX_20693478_ChIP-Seq_RETINA_Mouse0.63255962
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63157703
70NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63157703
71GATA6_25053715_ChIP-Seq_YYC3_Human0.62383341
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.62221940
73ETV1_20927104_ChIP-Seq_GIST48_Human0.61906695
74TCF4_18268006_ChIP-ChIP_LS174T_Human0.61378383
75CDX2_22108803_ChIP-Seq_LS180_Human0.59979238
76OCT4_18555785_Chip-Seq_ESCs_Mouse0.59520959
77IGF1R_20145208_ChIP-Seq_DFB_Human0.59101189
78KLF5_20875108_ChIP-Seq_MESCs_Mouse0.58637554
79NFYB_21822215_ChIP-Seq_K562_Human0.57850774
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.57514356
81ERG_20517297_ChIP-Seq_VCAP_Human0.57501264
82OCT4_21477851_ChIP-Seq_ESCs_Mouse0.56514470
83SMAD1_18555785_Chip-Seq_ESCs_Mouse0.56451684
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.56144562
85ESR2_21235772_ChIP-Seq_MCF-7_Human0.56057204
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54805774
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.54526083
88SPI1_20517297_ChIP-Seq_HL60_Human0.54034248
89P53_21459846_ChIP-Seq_SAOS-2_Human0.53662721
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.53042803
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.52722296
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.52596512
93SOX2_20726797_ChIP-Seq_SW620_Human0.52489608
94ESRRB_18555785_Chip-Seq_ESCs_Mouse0.52429486
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.52372267
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52172616
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.52155650
98RAC3_21632823_ChIP-Seq_H3396_Human0.51297348
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.48685061
100PU1_27457419_Chip-Seq_LIVER_Mouse0.48510282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005085_abnormal_gallbladder_physiolo6.42335027
2MP0005360_urolithiasis5.91123700
3MP0005365_abnormal_bile_salt5.87314936
4MP0008875_abnormal_xenobiotic_pharmacok5.66676276
5MP0003195_calcinosis4.73544457
6MP0002138_abnormal_hepatobiliary_system4.60705679
7MP0003252_abnormal_bile_duct4.50695792
8MP0003868_abnormal_feces_composition3.39325065
9MP0001666_abnormal_nutrient_absorption3.27418183
10MP0009697_abnormal_copulation2.83938263
11MP0010329_abnormal_lipoprotein_level2.72402548
12MP0003806_abnormal_nucleotide_metabolis2.44607280
13MP0005332_abnormal_amino_acid2.28800428
14MP0003191_abnormal_cellular_cholesterol2.12022336
15MP0002139_abnormal_hepatobiliary_system10.2883809
16MP0009840_abnormal_foam_cell1.96320939
17MP0002876_abnormal_thyroid_physiology1.93478107
18MP0000609_abnormal_liver_physiology1.86041981
19MP0010368_abnormal_lymphatic_system1.66582416
20MP0002118_abnormal_lipid_homeostasis1.65581230
21MP0001764_abnormal_homeostasis1.56485306
22MP0001661_extended_life_span1.47556009
23MP0005408_hypopigmentation1.35664674
24MP0009053_abnormal_anal_canal1.29983101
25MP0004019_abnormal_vitamin_homeostasis1.17463279
26MP0005319_abnormal_enzyme/_coenzyme1.14224516
27MP0005670_abnormal_white_adipose1.09665749
28MP0003656_abnormal_erythrocyte_physiolo1.07317331
29MP0000598_abnormal_liver_morphology1.04726616
30MP0002132_abnormal_respiratory_system1.03588400
31MP0005584_abnormal_enzyme/coenzyme_acti1.03239450
32MP0005451_abnormal_body_composition1.03234668
33MP0009643_abnormal_urine_homeostasis0.94004745
34MP0009764_decreased_sensitivity_to0.87501963
35MP0009763_increased_sensitivity_to0.85595596
36MP0003186_abnormal_redox_activity0.82413824
37MP0005187_abnormal_penis_morphology0.81896785
38MP0005376_homeostasis/metabolism_phenot0.81156680
39MP0001915_intracranial_hemorrhage0.80848854
40MP0009642_abnormal_blood_homeostasis0.80645875
41MP0008469_abnormal_protein_level0.80095165
42MP0000604_amyloidosis0.76952460
43MP0002282_abnormal_trachea_morphology0.75882056
44MP0002971_abnormal_brown_adipose0.74566122
45MP0003690_abnormal_glial_cell0.74477446
46MP0005636_abnormal_mineral_homeostasis0.68746458
47MP0003011_delayed_dark_adaptation0.67707087
48MP0005395_other_phenotype0.64621830
49MP0005464_abnormal_platelet_physiology0.64291228
50MP0005535_abnormal_body_temperature0.63652213
51MP0008872_abnormal_physiological_respon0.60743318
52MP0005266_abnormal_metabolism0.60100378
53MP0003638_abnormal_response/metabolism_0.58415980
54MP0002168_other_aberrant_phenotype0.57541872
55MP0005023_abnormal_wound_healing0.56989051
56MP0003879_abnormal_hair_cell0.55605918
57MP0002078_abnormal_glucose_homeostasis0.55227022
58MP0002249_abnormal_larynx_morphology0.54841344
59MP0008874_decreased_physiological_sensi0.54351245
60MP0005334_abnormal_fat_pad0.49365975
61MP0004130_abnormal_muscle_cell0.46142184
62MP0006036_abnormal_mitochondrial_physio0.44666664
63MP0009785_altered_susceptibility_to0.40320145
64MP0005164_abnormal_response_to0.39821792
65MP0000249_abnormal_blood_vessel0.37196312
66MP0004883_abnormal_blood_vessel0.36340487
67MP0009765_abnormal_xenobiotic_induced0.36173804
68MP0005647_abnormal_sex_gland0.32585083
69MP0001851_eye_inflammation0.32095045
70MP0000467_abnormal_esophagus_morphology0.32021405
71MP0003959_abnormal_lean_body0.30070906
72MP0005166_decreased_susceptibility_to0.29940476
73MP0005448_abnormal_energy_balance0.29646251
74MP0005220_abnormal_exocrine_pancreas0.29562466
75MP0005058_abnormal_lysosome_morphology0.29240074
76MP0002136_abnormal_kidney_physiology0.29105422
77MP0004782_abnormal_surfactant_physiolog0.27703933
78MP0005197_abnormal_uvea_morphology0.27015132
79MP0002332_abnormal_exercise_endurance0.26806933
80MP0002928_abnormal_bile_duct0.26022549
81MP0003075_altered_response_to0.23927106
82MP0003953_abnormal_hormone_level0.23743878
83MP0003718_maternal_effect0.23406397
84MP0003705_abnormal_hypodermis_morpholog0.23403625
85MP0000566_synostosis0.21960913
86MP0008873_increased_physiological_sensi0.21707994
87MP0000639_abnormal_adrenal_gland0.21425850
88MP0009115_abnormal_fat_cell0.21321896
89MP0003632_abnormal_nervous_system0.21285461
90MP0001756_abnormal_urination0.21249132
91MP0001881_abnormal_mammary_gland0.21182066
92MP0001845_abnormal_inflammatory_respons0.20505127
93MP0005084_abnormal_gallbladder_morpholo0.19342344
94MP0004142_abnormal_muscle_tone0.18787199
95MP0002128_abnormal_blood_circulation0.18273164
96MP0000920_abnormal_myelination0.18181180
97MP0003633_abnormal_nervous_system0.16249014
98MP0001545_abnormal_hematopoietic_system0.15702893
99MP0005397_hematopoietic_system_phenotyp0.15702893
100MP0001944_abnormal_pancreas_morphology0.14640248

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.95590954
2Complement deficiency (HP:0004431)9.82052491
3Prolonged partial thromboplastin time (HP:0003645)8.95195338
4Abnormality of aromatic amino acid family metabolism (HP:0004338)8.01284975
5Abnormality of complement system (HP:0005339)7.95241409
6Hypobetalipoproteinemia (HP:0003563)7.85112824
7Systemic lupus erythematosus (HP:0002725)6.08631983
8Joint hemorrhage (HP:0005261)6.07906958
9Intrahepatic cholestasis (HP:0001406)5.93542939
10* Conjugated hyperbilirubinemia (HP:0002908)5.61859127
11Hyperlipoproteinemia (HP:0010980)5.46293425
12Glomerulonephritis (HP:0000099)5.38996101
13Abnormality of the common coagulation pathway (HP:0010990)5.16984103
14Abnormality of pyrimidine metabolism (HP:0004353)4.84925553
15Xanthomatosis (HP:0000991)4.72035083
16Spontaneous abortion (HP:0005268)4.67961163
17Hypolipoproteinemia (HP:0010981)4.57007259
18Recurrent gram-negative bacterial infections (HP:0005420)4.51991468
19Abnormality of the intrinsic pathway (HP:0010989)4.12207492
20Nephritis (HP:0000123)4.03919656
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.00753749
22Fat malabsorption (HP:0002630)3.79279566
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.63095171
24Hyperglycinemia (HP:0002154)3.48632494
25Generalized aminoaciduria (HP:0002909)3.38387669
26Hyperammonemia (HP:0001987)3.30728964
27Abnormality of methionine metabolism (HP:0010901)3.22686877
28Gingival bleeding (HP:0000225)3.18197085
29Rickets (HP:0002748)3.13246022
30Hypoalphalipoproteinemia (HP:0003233)3.08938683
31Osteomalacia (HP:0002749)3.05647881
32Hypercholesterolemia (HP:0003124)2.99880217
33Mitral stenosis (HP:0001718)2.92439584
34Steatorrhea (HP:0002570)2.91911892
35Abnormality of serine family amino acid metabolism (HP:0010894)2.91021679
36Abnormality of glycine metabolism (HP:0010895)2.91021679
37Vascular calcification (HP:0004934)2.85803490
38Delayed CNS myelination (HP:0002188)2.85385461
39Abnormality of serum amino acid levels (HP:0003112)2.75433044
40Epidermoid cyst (HP:0200040)2.73371685
41Abnormality of nucleobase metabolism (HP:0010932)2.71522514
42Thrombophlebitis (HP:0004418)2.68041470
43Fair hair (HP:0002286)2.63932277
44Hemorrhage of the eye (HP:0011885)2.63424592
45Hyperglycinuria (HP:0003108)2.59173378
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54891260
47Cardiovascular calcification (HP:0011915)2.53106891
48Hepatocellular carcinoma (HP:0001402)2.52884554
49Purpura (HP:0000979)2.43863934
50Neonatal hypoglycemia (HP:0001998)2.42610310
51Pulmonary embolism (HP:0002204)2.39541322
52Cholelithiasis (HP:0001081)2.32472638
53Hyperphosphaturia (HP:0003109)2.31568271
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.28207474
55Reduced antithrombin III activity (HP:0001976)2.26368089
56* Hyperbilirubinemia (HP:0002904)2.24321281
57Abnormality of vitamin metabolism (HP:0100508)2.20601631
58Abnormal gallbladder morphology (HP:0012437)2.20234200
59Abnormal gallbladder physiology (HP:0012438)2.19393370
60Cholecystitis (HP:0001082)2.19393370
61Menorrhagia (HP:0000132)2.17764315
62Elevated alkaline phosphatase (HP:0003155)2.17488725
63Metabolic acidosis (HP:0001942)2.14840337
64Glycosuria (HP:0003076)2.11798984
65Abnormality of urine glucose concentration (HP:0011016)2.11798984
66Myocardial infarction (HP:0001658)2.03630534
67Abnormal enzyme/coenzyme activity (HP:0012379)2.01510804
68Bifid scrotum (HP:0000048)2.00298673
69Abnormality of monocarboxylic acid metabolism (HP:0010996)10.3570324
70Joint swelling (HP:0001386)1.99301226
71Irritability (HP:0000737)1.98919731
72Arthropathy (HP:0003040)1.96089018
73Abnormality of alkaline phosphatase activity (HP:0004379)1.95433943
74Ketosis (HP:0001946)1.92694977
75Hypophosphatemic rickets (HP:0004912)1.91985086
76Abnormality of the Achilles tendon (HP:0005109)1.89630066
77Increased mean platelet volume (HP:0011877)1.87086070
78Abnormal urine phosphate concentration (HP:0012599)1.85606456
79Abnormality of iron homeostasis (HP:0011031)1.82315054
80Hypochromic microcytic anemia (HP:0004840)1.82265437
81Generalized hypopigmentation of hair (HP:0011358)1.82081091
82Increased serum ferritin (HP:0003281)1.80007996
83Bile duct proliferation (HP:0001408)1.79909935
84Abnormal biliary tract physiology (HP:0012439)1.79909935
85Poikilocytosis (HP:0004447)1.74383383
86Abnormality of purine metabolism (HP:0004352)1.73712788
87Epistaxis (HP:0000421)1.71283251
88Abnormal platelet volume (HP:0011876)1.68679651
89Abnormality of transition element cation homeostasis (HP:0011030)1.66917941
90Gangrene (HP:0100758)1.66593897
91Cerebral palsy (HP:0100021)1.63675741
92Blue irides (HP:0000635)1.62911178
93Hydroxyprolinuria (HP:0003080)1.59568142
94Abnormality of proline metabolism (HP:0010907)1.59568142
95Skin nodule (HP:0200036)1.58570625
96Lethargy (HP:0001254)1.58532403
97Abnormality of the gallbladder (HP:0005264)1.58517032
98Abnormal delivery (HP:0001787)1.52613116
99Alkalosis (HP:0001948)1.51810729
100Pancreatitis (HP:0001733)1.51245259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG4.78753395
2ERN14.51814504
3FGFR43.67384209
4RIPK12.98959333
5TYK22.76140700
6PRKACG2.39964479
7EPHA32.30528408
8SIK12.30046263
9PIK3CA2.29387971
10MST1R2.17484478
11MAP3K32.06580744
12MAP2K42.05029094
13BCKDK2.04038397
14TRIB32.03791322
15PRPF4B2.01597211
16PRKAA21.90368452
17FGFR31.87190097
18NEK91.80393989
19MAPK111.74889358
20NTRK31.70654253
21PRKCG1.51953863
22IGF1R1.51510851
23TBK11.50739545
24ABL21.43969180
25JAK11.41798052
26MAP3K21.29315917
27JAK21.26954603
28PINK11.26874907
29CAMKK21.25905360
30NLK1.25574042
31IRAK31.23534566
32MAP2K31.17841285
33PDPK11.15777323
34ERBB21.14346792
35TNK21.09620092
36FER1.08036716
37PRKCZ1.07263263
38EPHA41.06464747
39TAOK31.04459911
40MET1.01968741
41MAP3K121.01624811
42CDK60.98046580
43PRKAA10.97719874
44PRKG10.96071877
45MYLK0.93895741
46FRK0.92882220
47PRKACA0.88844585
48EPHB10.87718324
49SCYL20.87439038
50ERBB40.84850771
51CSF1R0.82545756
52RET0.81466510
53BRSK20.80068429
54PDK10.79628395
55ZAP700.78991457
56ICK0.75935429
57CSNK1D0.74294876
58MAP3K60.73231202
59ACVR1B0.72694645
60MAP3K10.72642908
61DYRK1B0.71083966
62INSRR0.66813617
63SGK30.66559892
64CSNK1E0.65700383
65PRKCB0.65130819
66PRKCA0.64713081
67SGK4940.63202307
68SGK2230.63202307
69RPS6KA30.62415677
70SGK20.59835760
71MAP3K50.58258924
72KSR20.58062059
73AKT30.57704447
74MAP3K130.57303644
75PRKACB0.57276876
76BCR0.56523900
77GRK10.56276713
78SGK10.53746168
79TIE10.52879462
80DAPK20.49420652
81SRC0.48851456
82GSK3A0.48247748
83WNK30.47050579
84PTK60.46150853
85TAOK20.45642010
86MAPK40.45237610
87PKN20.44116470
88CSNK2A10.42715748
89CAMK2G0.41947134
90CAMKK10.41798262
91MAP3K110.39738815
92TGFBR20.37531920
93STK380.37391960
94CAMK1D0.37232661
95PDK20.36896439
96MAPK70.36738492
97CSNK1A10.36389260
98CDK90.35537293
99RPS6KB10.35279099
100MAPK120.35057823

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.55471486
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.02364418
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.92791111
4Complement and coagulation cascades_Homo sapiens_hsa046103.78085842
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.70199383
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.55155991
7Retinol metabolism_Homo sapiens_hsa008303.54311916
8Chemical carcinogenesis_Homo sapiens_hsa052043.01002658
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.00266162
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.83684581
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.75055175
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.72981473
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58027821
14Fatty acid degradation_Homo sapiens_hsa000712.44320981
15Arginine biosynthesis_Homo sapiens_hsa002202.39047107
16Phenylalanine metabolism_Homo sapiens_hsa003602.25949474
17Tyrosine metabolism_Homo sapiens_hsa003502.21885517
18Butanoate metabolism_Homo sapiens_hsa006502.10234601
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05926843
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.92517196
21Linoleic acid metabolism_Homo sapiens_hsa005911.88368350
22Tryptophan metabolism_Homo sapiens_hsa003801.87639344
23Histidine metabolism_Homo sapiens_hsa003401.85433576
24* Bile secretion_Homo sapiens_hsa049761.67836348
25Starch and sucrose metabolism_Homo sapiens_hsa005001.61704851
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56278022
27Vitamin B6 metabolism_Homo sapiens_hsa007501.38674954
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.33699139
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.32077423
30PPAR signaling pathway_Homo sapiens_hsa033201.31032552
31beta-Alanine metabolism_Homo sapiens_hsa004101.29337112
32Staphylococcus aureus infection_Homo sapiens_hsa051501.27055033
33Peroxisome_Homo sapiens_hsa041461.26143071
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24148595
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.20771337
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17830499
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16106136
38Arachidonic acid metabolism_Homo sapiens_hsa005901.11003219
39Prion diseases_Homo sapiens_hsa050201.10222694
40Pyruvate metabolism_Homo sapiens_hsa006201.02177535
41Biosynthesis of amino acids_Homo sapiens_hsa012301.01831478
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00877769
43Propanoate metabolism_Homo sapiens_hsa006400.92114251
44Arginine and proline metabolism_Homo sapiens_hsa003300.88159495
45ABC transporters_Homo sapiens_hsa020100.85026395
46Carbon metabolism_Homo sapiens_hsa012000.81417292
47Fatty acid metabolism_Homo sapiens_hsa012120.80059975
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78326041
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77531981
50One carbon pool by folate_Homo sapiens_hsa006700.77395059
51Fat digestion and absorption_Homo sapiens_hsa049750.75397257
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72261398
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69767013
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65444387
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.60150451
56Lysine degradation_Homo sapiens_hsa003100.51845516
57Metabolic pathways_Homo sapiens_hsa011000.41230393
58Sulfur metabolism_Homo sapiens_hsa009200.40556613
59Sulfur relay system_Homo sapiens_hsa041220.32622591
60Pertussis_Homo sapiens_hsa051330.29009581
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26216259
62Glycerolipid metabolism_Homo sapiens_hsa005610.25583303
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23272961
64Fatty acid elongation_Homo sapiens_hsa000620.18776620
65Insulin resistance_Homo sapiens_hsa049310.18179738
66Pentose phosphate pathway_Homo sapiens_hsa000300.15004689
67Fructose and mannose metabolism_Homo sapiens_hsa000510.12902690
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12549460
69Steroid biosynthesis_Homo sapiens_hsa001000.10909036
70Systemic lupus erythematosus_Homo sapiens_hsa053220.09840831
71Selenocompound metabolism_Homo sapiens_hsa004500.09314260
72Glucagon signaling pathway_Homo sapiens_hsa049220.08815948
73Vitamin digestion and absorption_Homo sapiens_hsa049770.06292784
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.05421770
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.05332946
76Fatty acid biosynthesis_Homo sapiens_hsa000610.03859210
77Glutathione metabolism_Homo sapiens_hsa004800.03433082
78Serotonergic synapse_Homo sapiens_hsa047260.01339340
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.2914670
80N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2732475
81Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2677309
82Ether lipid metabolism_Homo sapiens_hsa00565-0.2547991
83Circadian rhythm_Homo sapiens_hsa04710-0.2471953
84Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2438114
85Sphingolipid metabolism_Homo sapiens_hsa00600-0.2172819
86Type II diabetes mellitus_Homo sapiens_hsa04930-0.2120950
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2046508
88Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1891353
89Insulin signaling pathway_Homo sapiens_hsa04910-0.1797035
90African trypanosomiasis_Homo sapiens_hsa05143-0.1438879
91Nitrogen metabolism_Homo sapiens_hsa00910-0.1392977
92Mineral absorption_Homo sapiens_hsa04978-0.1385813
93Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1362338
94Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1229741
95Renin-angiotensin system_Homo sapiens_hsa04614-0.0879791
96Other glycan degradation_Homo sapiens_hsa00511-0.0853619
97Amoebiasis_Homo sapiens_hsa05146-0.0596620
98Folate biosynthesis_Homo sapiens_hsa00790-0.0292730
99AMPK signaling pathway_Homo sapiens_hsa04152-0.0291548
100Galactose metabolism_Homo sapiens_hsa00052-0.0211285

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