ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	9.27091372
2	positive regulation of digestive system process (GO:0060456)	6.89828311
3	positive regulation of action potential (GO:0045760)	6.27960461
4	regulation of glucocorticoid secretion (GO:2000849)	5.39593957
5	positive regulation of steroid hormone secretion (GO:2000833)	5.36225165
6	histone H3-K9 demethylation (GO:0033169)	5.32480186
7	regulation of corticosteroid hormone secretion (GO:2000846)	5.20803971
8	multicellular organism reproduction (GO:0032504)	4.86400306
9	positive regulation of synaptic transmission, GABAergic (GO:0032230)	4.64415387
10	negative regulation of heart rate (GO:0010459)	4.61908670
11	regulation of steroid hormone secretion (GO:2000831)	4.53403210
12	regulation of acrosome reaction (GO:0060046)	4.48018563
13	flavonoid metabolic process (GO:0009812)	4.19773773
14	cellular ketone body metabolic process (GO:0046950)	3.96857018
15	regulation of digestive system process (GO:0044058)	3.86111166
16	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.85113874
17	oocyte development (GO:0048599)	3.82190725
18	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.62807779
19	positive regulation of renal sodium excretion (GO:0035815)	3.61851726
20	regulation of action potential (GO:0098900)	3.59142044
21	meiotic cell cycle (GO:0051321)	3.58516492
22	male meiosis I (GO:0007141)	3.58419671
23	oxidative demethylation (GO:0070989)	3.47985478
24	ketone body metabolic process (GO:1902224)	3.39982752
25	negative regulation of hormone metabolic process (GO:0032351)	3.33815887
26	response to UV-C (GO:0010225)	3.33038441
27	protein K6-linked ubiquitination (GO:0085020)	3.31820697
28	negative regulation of protein activation cascade (GO:2000258)	3.30994802
29	binding of sperm to zona pellucida (GO:0007339)	3.28099260
30	negative regulation of hormone biosynthetic process (GO:0032353)	3.26434964
31	drug catabolic process (GO:0042737)	3.26302013
32	regulation of RIG-I signaling pathway (GO:0039535)	3.24980956
33	retinal cone cell development (GO:0046549)	3.23998399
34	indole-containing compound catabolic process (GO:0042436)	3.19207807
35	indolalkylamine catabolic process (GO:0046218)	3.19207807
36	tryptophan catabolic process (GO:0006569)	3.19207807
37	early endosome to late endosome transport (GO:0045022)	3.14334812
38	centriole replication (GO:0007099)	3.14204886
39	epoxygenase P450 pathway (GO:0019373)	3.10392375
40	single fertilization (GO:0007338)	3.06050665
41	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	3.03703679
42	phenylpropanoid metabolic process (GO:0009698)	3.03092549
43	sperm-egg recognition (GO:0035036)	3.02378017
44	reproduction (GO:0000003)	3.01751377
45	bile acid biosynthetic process (GO:0006699)	3.01629150
46	regulation of DNA endoreduplication (GO:0032875)	3.00242610
47	synaptonemal complex organization (GO:0070193)	2.97630788
48	omega-hydroxylase P450 pathway (GO:0097267)	2.96389294
49	establishment of protein localization to Golgi (GO:0072600)	2.96256372
50	centrosome duplication (GO:0051298)	2.95789502
51	water-soluble vitamin biosynthetic process (GO:0042364)	2.95405017
52	synaptonemal complex assembly (GO:0007130)	2.94351126
53	aromatic amino acid family catabolic process (GO:0009074)	2.93453721
54	positive regulation of protein autophosphorylation (GO:0031954)	2.93061823
55	L-phenylalanine metabolic process (GO:0006558)	2.92902081
56	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.92902081
57	regulation of female gonad development (GO:2000194)	2.90229693
58	bile acid metabolic process (GO:0008206)	2.88802538
59	respiratory tube development (GO:0030323)	2.88526356
60	meiosis I (GO:0007127)	2.86375907
61	sodium-independent organic anion transport (GO:0043252)	2.84353966
62	regulation of endocrine process (GO:0044060)	2.84129492
63	S-adenosylmethionine metabolic process (GO:0046500)	2.84126675
64	indolalkylamine metabolic process (GO:0006586)	2.83963136
65	negative regulation of complement activation (GO:0045916)	2.81394352
66	resolution of meiotic recombination intermediates (GO:0000712)	2.79291733
67	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.78608347
68	protein targeting to Golgi (GO:0000042)	2.75929481
69	fertilization (GO:0009566)	2.75197378
70	piRNA metabolic process (GO:0034587)	2.75175191
71	exogenous drug catabolic process (GO:0042738)	2.75020834
72	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.73960679
73	protein K11-linked deubiquitination (GO:0035871)	2.73567632
74	cellular glucuronidation (GO:0052695)	2.73236075
75	protein K48-linked deubiquitination (GO:0071108)	2.72669128
76	gamma-aminobutyric acid transport (GO:0015812)	2.72009477
77	glucuronate metabolic process (GO:0019585)	2.70254921
78	uronic acid metabolic process (GO:0006063)	2.70254921
79	opsonization (GO:0008228)	2.68843212
80	regulation of female receptivity (GO:0045924)	2.68473802
81	regulation of exit from mitosis (GO:0007096)	2.67534954
82	positive regulation of meiotic cell cycle (GO:0051446)	2.65718010
83	positive regulation of meiosis (GO:0045836)	2.65439553
84	transcription from mitochondrial promoter (GO:0006390)	2.64501974
85	L-phenylalanine catabolic process (GO:0006559)	2.64480375
86	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.64480375
87	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.64341106
88	centrosome localization (GO:0051642)	2.62304151
89	protein localization to Golgi apparatus (GO:0034067)	2.60893961
90	regulation of fibrinolysis (GO:0051917)	2.58389998
91	negative regulation of keratinocyte proliferation (GO:0010839)	2.57623087
92	acrosome reaction (GO:0007340)	2.56698458
93	positive regulation of histone H3-K4 methylation (GO:0051571)	2.56508188
94	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.53485444
95	kynurenine metabolic process (GO:0070189)	2.52344818
96	positive regulation of endothelial cell differentiation (GO:0045603)	2.52009380
97	regulation of synaptic transmission, GABAergic (GO:0032228)	2.51737815
98	tryptophan metabolic process (GO:0006568)	2.51278725
99	protein K63-linked deubiquitination (GO:0070536)	2.49655052
100	aromatic amino acid family metabolic process (GO:0009072)	2.49386769

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.24747062
2	VDR_22108803_ChIP-Seq_LS180_Human	3.23037326
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.07023411
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.99860865
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.98235673
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.95964662
7	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.91222294
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.64450560
9	FUS_26573619_Chip-Seq_HEK293_Human	2.49855875
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.40944246
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.38929995
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.35908582
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.31745476
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.28512117
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.27052257
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.26733726
17	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.23298071
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.21450578
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10148574
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.08602002
21	SMAD4_21799915_ChIP-Seq_A2780_Human	2.05919237
22	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.02752046
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01919211
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.00111449
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.96180972
26	P300_19829295_ChIP-Seq_ESCs_Human	1.91257870
27	STAT3_23295773_ChIP-Seq_U87_Human	1.83902821
28	EWS_26573619_Chip-Seq_HEK293_Human	1.82491743
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.77336166
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76032555
31	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.68679648
32	TCF4_23295773_ChIP-Seq_U87_Human	1.68536003
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65016122
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59188235
35	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.58804468
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.57993408
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57993408
38	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.56275015
39	AR_25329375_ChIP-Seq_VCAP_Human	1.55522271
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.53974500
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52693356
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.51348456
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47207039
44	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.42526007
45	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.39440470
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38253626
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.37926574
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.37878056
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37805539
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.37456561
51	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.34289953
52	CBP_21632823_ChIP-Seq_H3396_Human	1.34158275
53	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.33916570
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.31388335
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30996339
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30421734
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25329392
58	CDX2_22108803_ChIP-Seq_LS180_Human	1.24948329
59	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.24323485
60	CJUN_26792858_Chip-Seq_BT549_Human	1.23746690
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23526855
62	GATA4_25053715_ChIP-Seq_YYC3_Human	1.22101716
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21439260
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20678776
65	TP53_16413492_ChIP-PET_HCT116_Human	1.19313350
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.19242692
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18970012
68	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15588692
69	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.15537780
70	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15514885
71	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.15213374
72	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14706383
73	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.14418472
74	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.14282442
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10795073
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.10654224
77	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.09869819
78	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09696250
79	TP63_23658742_ChIP-Seq_EP156T_Human	1.08883603
80	MYC_18940864_ChIP-ChIP_HL60_Human	1.08382958
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07493410
82	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06977910
83	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06977910
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06428529
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06023132
86	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05512931
87	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.04150469
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04112241
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03645525
90	KDM2B_26808549_Chip-Seq_REH_Human	1.03079948
91	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.02616292
92	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02329387
93	TP53_18474530_ChIP-ChIP_U2OS_Human	1.01100638
94	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01084640
95	NCOR_22424771_ChIP-Seq_293T_Human	0.99849630
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98809134
97	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.98783817
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98458019
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97609823
100	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.95760949

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.43871347
2	MP0010386_abnormal_urinary_bladder	4.13748458
3	MP0001986_abnormal_taste_sensitivity	4.07870302
4	MP0003718_maternal_effect	3.26922627
5	MP0002138_abnormal_hepatobiliary_system	2.81886537
6	MP0005360_urolithiasis	2.74152944
7	MP0003879_abnormal_hair_cell	2.51853284
8	MP0005085_abnormal_gallbladder_physiolo	2.44292505
9	MP0008875_abnormal_xenobiotic_pharmacok	2.44057608
10	MP0006292_abnormal_olfactory_placode	2.32163680
11	MP0005410_abnormal_fertilization	2.16056619
12	MP0003195_calcinosis	2.14522658
13	MP0008877_abnormal_DNA_methylation	2.09533870
14	MP0003890_abnormal_embryonic-extraembry	2.06878971
15	MP0008057_abnormal_DNA_replication	2.03216628
16	MP0009780_abnormal_chondrocyte_physiolo	1.93765893
17	MP0008058_abnormal_DNA_repair	1.90678074
18	MP0003868_abnormal_feces_composition	1.89569211
19	MP0003252_abnormal_bile_duct	1.86052350
20	MP0003950_abnormal_plasma_membrane	1.83757717
21	MP0002160_abnormal_reproductive_system	1.81757995
22	MP0002234_abnormal_pharynx_morphology	1.73490529
23	MP0005670_abnormal_white_adipose	1.73449877
24	MP0000427_abnormal_hair_cycle	1.72335486
25	MP0003693_abnormal_embryo_hatching	1.72053583
26	MP0001929_abnormal_gametogenesis	1.71447392
27	MP0003119_abnormal_digestive_system	1.68524766
28	MP0002876_abnormal_thyroid_physiology	1.68009349
29	MP0003183_abnormal_peptide_metabolism	1.66708629
30	MP0005365_abnormal_bile_salt	1.65990118
31	MP0001666_abnormal_nutrient_absorption	1.65078687
32	MP0006054_spinal_hemorrhage	1.52665701
33	MP0004019_abnormal_vitamin_homeostasis	1.50646025
34	MP0005646_abnormal_pituitary_gland	1.50479186
35	MP0005551_abnormal_eye_electrophysiolog	1.46945942
36	MP0010329_abnormal_lipoprotein_level	1.45990036
37	MP0010094_abnormal_chromosome_stability	1.44722051
38	MP0000569_abnormal_digit_pigmentation	1.43457006
39	MP0002272_abnormal_nervous_system	1.41572913
40	MP0000647_abnormal_sebaceous_gland	1.37106172
41	MP0003699_abnormal_female_reproductive	1.29377570
42	MP0002210_abnormal_sex_determination	1.27395350
43	MP0006276_abnormal_autonomic_nervous	1.26588055
44	MP0001664_abnormal_digestion	1.24036891
45	MP0009840_abnormal_foam_cell	1.15449328
46	MP0004134_abnormal_chest_morphology	1.15199048
47	MP0000653_abnormal_sex_gland	1.13580337
48	MP0009046_muscle_twitch	1.10899454
49	MP0002090_abnormal_vision	1.09708486
50	MP0003698_abnormal_male_reproductive	1.09417990
51	MP0001486_abnormal_startle_reflex	1.05139771
52	MP0002734_abnormal_mechanical_nocicepti	1.01337043
53	MP0000678_abnormal_parathyroid_gland	1.00711620
54	MP0002751_abnormal_autonomic_nervous	1.00140760
55	MP0005647_abnormal_sex_gland	0.99746811
56	MP0008872_abnormal_physiological_respon	0.99059930
57	MP0001756_abnormal_urination	0.97280084
58	MP0004270_analgesia	0.97189456
59	MP0005266_abnormal_metabolism	0.94262984
60	MP0001984_abnormal_olfaction	0.94081705
61	MP0001145_abnormal_male_reproductive	0.93664264
62	MP0002161_abnormal_fertility/fecundity	0.92682679
63	MP0000631_abnormal_neuroendocrine_gland	0.92258990
64	MP0009697_abnormal_copulation	0.92161206
65	MP0003283_abnormal_digestive_organ	0.91801761
66	MP0001968_abnormal_touch/_nociception	0.90375530
67	MP0005395_other_phenotype	0.89915865
68	MP0001764_abnormal_homeostasis	0.88977285
69	MP0005408_hypopigmentation	0.88606416
70	MP0009745_abnormal_behavioral_response	0.87734783
71	MP0010234_abnormal_vibrissa_follicle	0.86525036
72	MP0004130_abnormal_muscle_cell	0.86203112
73	MP0005389_reproductive_system_phenotype	0.85251195
74	MP0002233_abnormal_nose_morphology	0.84782734
75	MP0009053_abnormal_anal_canal	0.84201517
76	MP0000358_abnormal_cell_content/	0.84102829
77	MP0002736_abnormal_nociception_after	0.83616191
78	MP0002089_abnormal_postnatal_growth/wei	0.82864500
79	MP0001485_abnormal_pinna_reflex	0.79019285
80	MP0004142_abnormal_muscle_tone	0.78073503
81	MP0005376_homeostasis/metabolism_phenot	0.76754920
82	MP0002184_abnormal_innervation	0.76746575
83	MP0002735_abnormal_chemical_nociception	0.75894007
84	MP0003077_abnormal_cell_cycle	0.75727150
85	MP0005187_abnormal_penis_morphology	0.75450029
86	MP0002332_abnormal_exercise_endurance	0.74738365
87	MP0001119_abnormal_female_reproductive	0.74226201
88	MP0003186_abnormal_redox_activity	0.74202397
89	MP0001970_abnormal_pain_threshold	0.70280743
90	MP0008789_abnormal_olfactory_epithelium	0.69239015
91	MP0003937_abnormal_limbs/digits/tail_de	0.68546767
92	MP0005332_abnormal_amino_acid	0.67885221
93	MP0001501_abnormal_sleep_pattern	0.66042242
94	MP0001502_abnormal_circadian_rhythm	0.65393905
95	MP0004215_abnormal_myocardial_fiber	0.61601619
96	MP0003880_abnormal_central_pattern	0.60412418
97	MP0009250_abnormal_appendicular_skeleto	0.59676793
98	MP0006072_abnormal_retinal_apoptosis	0.57181179
99	MP0008932_abnormal_embryonic_tissue	0.56267610
100	MP0002084_abnormal_developmental_patter	0.56048583

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Conjugated hyperbilirubinemia (HP:0002908)	4.58403486
2	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.16411408
3	Papillary thyroid carcinoma (HP:0002895)	3.97511096
4	Spontaneous abortion (HP:0005268)	3.65202433
5	Abnormality of methionine metabolism (HP:0010901)	3.59711496
6	Short tibia (HP:0005736)	3.35120021
7	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.33637754
8	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.33637754
9	Epidermoid cyst (HP:0200040)	3.20775085
10	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.18291132
11	Gaze-evoked nystagmus (HP:0000640)	3.16330041
12	Intrahepatic cholestasis (HP:0001406)	3.15195892
13	Adrenal hypoplasia (HP:0000835)	3.03526681
14	Hypobetalipoproteinemia (HP:0003563)	3.02905266
15	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.96630569
16	Chronic hepatic failure (HP:0100626)	2.96130300
17	Congenital sensorineural hearing impairment (HP:0008527)	2.83639178
18	Renal cortical cysts (HP:0000803)	2.82325277
19	Genetic anticipation (HP:0003743)	2.82126911
20	Methylmalonic acidemia (HP:0002912)	2.80470939
21	Azoospermia (HP:0000027)	2.79622059
22	Fair hair (HP:0002286)	2.76770606
23	Prolonged partial thromboplastin time (HP:0003645)	2.74394984
24	Thyroid carcinoma (HP:0002890)	2.71830851
25	Hypophosphatemic rickets (HP:0004912)	2.67451389
26	Abnormality of the corticospinal tract (HP:0002492)	2.66405478
27	Abnormality of vitamin B metabolism (HP:0004340)	2.65111457
28	Pendular nystagmus (HP:0012043)	2.65049331
29	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.64126269
30	Homocystinuria (HP:0002156)	2.62296144
31	Abnormality of homocysteine metabolism (HP:0010919)	2.62296144
32	Premature ovarian failure (HP:0008209)	2.59011388
33	Abnormality of chromosome stability (HP:0003220)	2.56467214
34	Male infertility (HP:0003251)	2.54878216
35	Agitation (HP:0000713)	2.52792789
36	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.52696678
37	Chromsome breakage (HP:0040012)	2.47685667
38	Abnormality of the common coagulation pathway (HP:0010990)	2.46693328
39	Attenuation of retinal blood vessels (HP:0007843)	2.45978835
40	Abnormality of the nasal septum (HP:0000419)	2.45739947
41	Confusion (HP:0001289)	2.40330521
42	Hyperlipoproteinemia (HP:0010980)	2.40195222
43	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.36969885
44	Termporal pattern (HP:0011008)	2.36437844
45	Insidious onset (HP:0003587)	2.36437844
46	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.35311476
47	Megaloblastic anemia (HP:0001889)	2.33455362
48	Pancreatic fibrosis (HP:0100732)	2.32330429
49	Chorioretinal atrophy (HP:0000533)	2.31876906
50	Proximal tubulopathy (HP:0000114)	2.26937377
51	Abnormal auditory evoked potentials (HP:0006958)	2.25336231
52	Abnormality of vitamin metabolism (HP:0100508)	2.23497265
53	Poikiloderma (HP:0001029)	2.22830831
54	Abnormal spermatogenesis (HP:0008669)	2.19854219
55	Abnormality of the preputium (HP:0100587)	2.19318142
56	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.18264752
57	Sensory axonal neuropathy (HP:0003390)	2.16822467
58	Neonatal respiratory distress (HP:0002643)	2.16116260
59	Hypolipoproteinemia (HP:0010981)	2.12479563
60	Decreased central vision (HP:0007663)	2.09177032
61	Hypokinesia (HP:0002375)	2.09168074
62	Abnormality of DNA repair (HP:0003254)	2.05406126
63	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.04906763
64	Metaphyseal dysplasia (HP:0100255)	2.04520460
65	Prominent nose (HP:0000448)	2.04335863
66	Truncal obesity (HP:0001956)	2.02299221
67	Fat malabsorption (HP:0002630)	2.00479795
68	Hypoglycemic coma (HP:0001325)	1.99808798
69	Median cleft lip (HP:0000161)	1.99361419
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94157196
71	Methylmalonic aciduria (HP:0012120)	1.92214202
72	Entropion (HP:0000621)	1.90010562
73	Meckel diverticulum (HP:0002245)	1.89842685
74	Submucous cleft hard palate (HP:0000176)	1.89681150
75	Progressive cerebellar ataxia (HP:0002073)	1.88718046
76	Tongue fasciculations (HP:0001308)	1.87992805
77	Steatorrhea (HP:0002570)	1.87229250
78	Disinhibition (HP:0000734)	1.85752018
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.85513210
80	Medial flaring of the eyebrow (HP:0010747)	1.80960210
81	Abnormality of the ileum (HP:0001549)	1.79928113
82	Pancreatic cysts (HP:0001737)	1.79254329
83	Generalized hypopigmentation of hair (HP:0011358)	1.77796221
84	3-Methylglutaconic aciduria (HP:0003535)	1.75867252
85	Hypoalphalipoproteinemia (HP:0003233)	1.74480580
86	Horizontal nystagmus (HP:0000666)	1.74364958
87	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.74023399
88	Optic nerve hypoplasia (HP:0000609)	1.73568354
89	Poor coordination (HP:0002370)	1.72344696
90	Impaired vibratory sensation (HP:0002495)	1.71479550
91	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.70910369
92	Generalized aminoaciduria (HP:0002909)	1.70729809
93	Abnormality of the renal cortex (HP:0011035)	1.70558636
94	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.68273952
95	Abnormality of alanine metabolism (HP:0010916)	1.68273952
96	Hyperalaninemia (HP:0003348)	1.68273952
97	Severe muscular hypotonia (HP:0006829)	1.67767501
98	Impaired vibration sensation in the lower limbs (HP:0002166)	1.67744550
99	Upper limb muscle weakness (HP:0003484)	1.67364054
100	Urinary urgency (HP:0000012)	1.67313775

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.31086194
2	PDK2	4.32948841
3	MST1R	3.83274862
4	PBK	3.13619886
5	MAP3K9	2.72362851
6	MET	2.67233670
7	STK16	2.49968175
8	EPHA2	2.38845306
9	STK38L	2.36295781
10	CDC7	2.28693329
11	TRIM28	2.27964067
12	STK39	1.87314840
13	EPHA4	1.73667088
14	STK24	1.71010270
15	EIF2AK3	1.64228720
16	LATS1	1.62494445
17	ZAK	1.60885246
18	NEK6	1.59624467
19	ACVR1B	1.57683558
20	MST4	1.49559122
21	PINK1	1.49550392
22	TAOK3	1.36585432
23	BMPR1B	1.34572419
24	AKT3	1.33997692
25	TNIK	1.28106434
26	MAP3K4	1.24855394
27	BRAF	1.23578880
28	ADRBK2	1.22154969
29	STK3	1.21104699
30	WNK4	1.20766943
31	INSRR	1.15150166
32	PRKD3	1.14448081
33	PRKCE	1.13503767
34	GRK1	1.11117323
35	PLK1	1.07527978
36	BRSK2	1.04210838
37	SRPK1	1.02780964
38	PLK4	1.02203661
39	PRKCI	1.01336221
40	LATS2	0.99170209
41	AURKA	0.98299517
42	NTRK3	0.94222277
43	CASK	0.93017896
44	DYRK3	0.90663969
45	EIF2AK1	0.88254196
46	LMTK2	0.87008751
47	OXSR1	0.85165678
48	VRK1	0.82791233
49	NUAK1	0.82276554
50	MAP2K7	0.78944368
51	AURKB	0.78788152
52	TTK	0.78751154
53	MKNK2	0.78338306
54	MAPK13	0.77560058
55	ARAF	0.76075213
56	CHEK2	0.74990055
57	CDK9	0.74627495
58	ERBB3	0.74399340
59	BCR	0.74300417
60	PLK3	0.71956711
61	ERBB4	0.71043305
62	CAMK2A	0.64849030
63	BUB1	0.64706505
64	MAP3K3	0.64233386
65	FLT3	0.64194490
66	WNK3	0.61148548
67	RPS6KA4	0.58589004
68	CDK12	0.57289079
69	PIK3CG	0.56801276
70	CHEK1	0.56049628
71	BMX	0.53118702
72	PRKD2	0.51822154
73	CAMK2B	0.51450843
74	RPS6KA5	0.51124637
75	FER	0.50769046
76	CSNK1G1	0.49543092
77	PKN1	0.48974135
78	TLK1	0.48382678
79	PRKACB	0.47917596
80	MAP3K12	0.45677470
81	AKT2	0.45450517
82	SIK3	0.45391513
83	MAP3K5	0.45138700
84	CAMK2G	0.42007910
85	PLK2	0.40357256
86	MKNK1	0.40131543
87	ATM	0.39670839
88	MELK	0.39551465
89	ABL2	0.39518880
90	CSNK1E	0.38778550
91	MAPKAPK3	0.38237030
92	GSK3A	0.35660203
93	PHKG1	0.35554280
94	PHKG2	0.35554280
95	CAMKK2	0.34981969
96	PRKG2	0.34393505
97	CAMK4	0.34045743
98	PRKACA	0.33939049
99	CSNK1G2	0.33099097
100	PRKG1	0.33048556

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.42204132
2	Caffeine metabolism_Homo sapiens_hsa00232	3.04322065
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.99921516
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.59440070
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.31163009
6	Basal transcription factors_Homo sapiens_hsa03022	2.28750731
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.25379752
8	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.23506919
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.23233613
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.22838635
11	Retinol metabolism_Homo sapiens_hsa00830	2.22191505
12	Nicotine addiction_Homo sapiens_hsa05033	2.12685067
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.09759241
14	Butanoate metabolism_Homo sapiens_hsa00650	2.06603595
15	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.98098511
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.93097866
17	Sulfur metabolism_Homo sapiens_hsa00920	1.91952506
18	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.91166469
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.72880017
20	Complement and coagulation cascades_Homo sapiens_hsa04610	1.72442407
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.65321548
22	Homologous recombination_Homo sapiens_hsa03440	1.54575994
23	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.50522398
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.42829706
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42131099
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39352793
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35651913
28	ABC transporters_Homo sapiens_hsa02010	1.33925823
29	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.33441759
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.32831589
31	Sphingolipid metabolism_Homo sapiens_hsa00600	1.28893405
32	Olfactory transduction_Homo sapiens_hsa04740	1.25938494
33	Taste transduction_Homo sapiens_hsa04742	1.25082440
34	* Bile secretion_Homo sapiens_hsa04976	1.23668327
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.22286021
36	Fatty acid degradation_Homo sapiens_hsa00071	1.21883947
37	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.15972668
38	Fatty acid elongation_Homo sapiens_hsa00062	1.12915732
39	Circadian rhythm_Homo sapiens_hsa04710	1.10370193
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.08123060
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.07967284
42	PPAR signaling pathway_Homo sapiens_hsa03320	1.06363878
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.04496167
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01035618
45	Peroxisome_Homo sapiens_hsa04146	0.99927188
46	RNA polymerase_Homo sapiens_hsa03020	0.98544670
47	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.97970379
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.96968775
49	Glycerolipid metabolism_Homo sapiens_hsa00561	0.95917767
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93804614
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88383706
52	Alcoholism_Homo sapiens_hsa05034	0.87693651
53	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.87639832
54	Glutathione metabolism_Homo sapiens_hsa00480	0.84226465
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.82375299
56	Propanoate metabolism_Homo sapiens_hsa00640	0.82161623
57	Oocyte meiosis_Homo sapiens_hsa04114	0.81121334
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.78193802
59	Folate biosynthesis_Homo sapiens_hsa00790	0.77483194
60	RNA transport_Homo sapiens_hsa03013	0.75889953
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.75465463
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.74466936
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.74039846
64	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.69852624
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.69682878
66	Phototransduction_Homo sapiens_hsa04744	0.69485231
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.69160054
68	Histidine metabolism_Homo sapiens_hsa00340	0.68271085
69	Purine metabolism_Homo sapiens_hsa00230	0.67675399
70	p53 signaling pathway_Homo sapiens_hsa04115	0.67411548
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66891659
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65422923
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.63869175
74	RNA degradation_Homo sapiens_hsa03018	0.61996232
75	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.59232016
76	Regulation of autophagy_Homo sapiens_hsa04140	0.59094415
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58112400
78	Hippo signaling pathway_Homo sapiens_hsa04390	0.57165859
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53869401
80	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.52909420
81	Arginine biosynthesis_Homo sapiens_hsa00220	0.52330418
82	GABAergic synapse_Homo sapiens_hsa04727	0.50696763
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50153471
84	Cell cycle_Homo sapiens_hsa04110	0.48764919
85	Metabolic pathways_Homo sapiens_hsa01100	0.48277975
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.47417859
87	Mismatch repair_Homo sapiens_hsa03430	0.46036855
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.45184168
89	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.44736135
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44143736
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43306611
92	DNA replication_Homo sapiens_hsa03030	0.42554903
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42443276
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41989358
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.41455355
96	Serotonergic synapse_Homo sapiens_hsa04726	0.40879913
97	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.38689356
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.37748074
99	Protein export_Homo sapiens_hsa03060	0.35208295
100	Morphine addiction_Homo sapiens_hsa05032	0.33681097

SLCO1B7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »