SLCO1C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)6.67653727
2presynaptic membrane assembly (GO:0097105)6.09942047
3C4-dicarboxylate transport (GO:0015740)5.70501875
4amino acid import (GO:0043090)5.66526927
5L-amino acid import (GO:0043092)5.39605338
6lymph vessel development (GO:0001945)5.33960224
7positive regulation of potassium ion transmembrane transporter activity (GO:1901018)5.22272831
8regulation of cardiac muscle cell contraction (GO:0086004)5.21735999
9presynaptic membrane organization (GO:0097090)5.18841649
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.04866596
11cellular sodium ion homeostasis (GO:0006883)4.97880633
12peptidyl-tyrosine autophosphorylation (GO:0038083)4.95234392
13alanine transport (GO:0032328)4.95111629
14negative regulation of cytosolic calcium ion concentration (GO:0051481)4.87625823
15layer formation in cerebral cortex (GO:0021819)4.54345445
16positive regulation of dendritic spine morphogenesis (GO:0061003)4.50616982
17cell morphogenesis involved in neuron differentiation (GO:0048667)4.44840252
18auditory behavior (GO:0031223)4.35417243
19vascular endothelial growth factor signaling pathway (GO:0038084)4.23023989
20regulation of synapse structural plasticity (GO:0051823)4.08537422
21dermatan sulfate biosynthetic process (GO:0030208)4.07865025
22regulation of actin filament-based movement (GO:1903115)3.98361709
23endothelial cell differentiation (GO:0045446)3.88917529
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83793509
25L-serine transport (GO:0015825)3.79004323
26positive regulation of cellular amide metabolic process (GO:0034250)3.75585551
27positive regulation of potassium ion transmembrane transport (GO:1901381)3.75468898
28potassium ion import (GO:0010107)3.72989479
29response to auditory stimulus (GO:0010996)3.71189039
30vocalization behavior (GO:0071625)3.67608145
31oligodendrocyte differentiation (GO:0048709)3.65390820
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.64990114
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.55277971
34positive regulation of dendritic spine development (GO:0060999)3.53863923
35gamma-aminobutyric acid transport (GO:0015812)3.53243390
36negative regulation of astrocyte differentiation (GO:0048712)3.51336075
37cellular response to cholesterol (GO:0071397)3.44257378
38cerebral cortex radially oriented cell migration (GO:0021799)3.41328448
39blood vessel maturation (GO:0001955)3.38399463
40positive regulation of vasculogenesis (GO:2001214)3.33058813
41locomotory exploration behavior (GO:0035641)3.30261759
42mechanosensory behavior (GO:0007638)3.28227507
43chondroitin sulfate catabolic process (GO:0030207)3.28018282
44cellular potassium ion homeostasis (GO:0030007)3.27370306
45negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.26130346
46regulation of beta-amyloid formation (GO:1902003)3.20110963
47serine transport (GO:0032329)3.19829417
48regulation of vasculogenesis (GO:2001212)3.19751131
49proline transport (GO:0015824)3.19476566
50cerebellar granule cell differentiation (GO:0021707)3.18891560
51cochlea development (GO:0090102)3.16378188
52neuron recognition (GO:0008038)3.13816697
53neurotransmitter-gated ion channel clustering (GO:0072578)3.12050351
54atrial cardiac muscle cell action potential (GO:0086014)3.12020439
55regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.09928125
56synaptic vesicle exocytosis (GO:0016079)3.09557056
57regulation of dendritic spine morphogenesis (GO:0061001)3.07813474
58regulation of respiratory system process (GO:0044065)3.06217617
59positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.04047858
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.02888253
61microglial cell activation (GO:0001774)3.02823173
62cAMP-mediated signaling (GO:0019933)3.00061909
63pyrimidine nucleobase catabolic process (GO:0006208)3.00024677
64cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.99574877
65heart trabecula morphogenesis (GO:0061384)2.99218326
66negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98902835
67axon ensheathment in central nervous system (GO:0032291)2.98123403
68central nervous system myelination (GO:0022010)2.98123403
69vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.97729265
70glial cell proliferation (GO:0014009)2.96580219
71regulation of glutamate receptor signaling pathway (GO:1900449)2.95968118
72regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.95020526
73acidic amino acid transport (GO:0015800)2.92927728
74cell communication involved in cardiac conduction (GO:0086065)2.91794312
75sodium ion homeostasis (GO:0055078)2.91467371
76membrane repolarization (GO:0086009)2.90507383
77membrane depolarization during action potential (GO:0086010)2.90327707
78positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.90033780
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89470478
80negative regulation of neurotransmitter transport (GO:0051589)2.88031245
81regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.86761296
82otic vesicle formation (GO:0030916)2.86114195
83serotonin metabolic process (GO:0042428)2.84822760
84positive regulation of monocyte chemotaxis (GO:0090026)2.84429658
85cellular response to sterol (GO:0036315)2.83889865
86dicarboxylic acid biosynthetic process (GO:0043650)2.83209321
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79689845
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.78915818
89regulation of astrocyte differentiation (GO:0048710)2.78187690
90heart valve formation (GO:0003188)2.76927322
91positive regulation of potassium ion transport (GO:0043268)2.76845830
92protein localization to synapse (GO:0035418)2.76481945
93phenol-containing compound catabolic process (GO:0019336)2.76386390
94patterning of blood vessels (GO:0001569)2.72974714
95regulation of dendritic spine development (GO:0060998)2.71713202
96relaxation of cardiac muscle (GO:0055119)2.71210296
97synaptic vesicle maturation (GO:0016188)2.71192911
98fatty acid elongation (GO:0030497)2.70005071
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69493479
100cerebellar Purkinje cell layer development (GO:0021680)2.69183194
101limb bud formation (GO:0060174)2.68262404
102modified amino acid transport (GO:0072337)2.67227815
103glutamate receptor signaling pathway (GO:0007215)2.65201282
104regulation of voltage-gated calcium channel activity (GO:1901385)2.64846313
105inositol phosphate-mediated signaling (GO:0048016)2.61949878
106neuron-neuron synaptic transmission (GO:0007270)2.61754007
107central nervous system projection neuron axonogenesis (GO:0021952)2.61350406
108negative regulation of glial cell differentiation (GO:0045686)2.60023985
109astrocyte development (GO:0014002)2.59206733
110eye photoreceptor cell differentiation (GO:0001754)2.58984211
111photoreceptor cell differentiation (GO:0046530)2.58984211
112transmission of nerve impulse (GO:0019226)2.58136746
113lung epithelium development (GO:0060428)2.57247345
114cyclic-nucleotide-mediated signaling (GO:0019935)2.56505876
115gamma-aminobutyric acid signaling pathway (GO:0007214)2.56184056
116neurotransmitter uptake (GO:0001504)2.55737656
117vitamin A metabolic process (GO:0006776)2.54045533
118negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.53434331
119one-carbon compound transport (GO:0019755)2.53222744
120regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52163280
121neurotransmitter secretion (GO:0007269)2.52073803
122surfactant homeostasis (GO:0043129)2.51528411
123neuron cell-cell adhesion (GO:0007158)2.50185570
124positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.50171643
125regulation of amyloid precursor protein catabolic process (GO:1902991)2.49536181
126L-glutamate transport (GO:0015813)2.48706748
127positive regulation of muscle hypertrophy (GO:0014742)2.48199766
128positive regulation of cardiac muscle hypertrophy (GO:0010613)2.48199766
129negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47950318
130low-density lipoprotein particle remodeling (GO:0034374)2.47563467
131cell communication by electrical coupling (GO:0010644)2.47409789
132artery smooth muscle contraction (GO:0014824)2.47208415
133retina vasculature morphogenesis in camera-type eye (GO:0061299)2.47177631
134regulation of timing of cell differentiation (GO:0048505)2.46825318
135neuronal action potential propagation (GO:0019227)2.46007197
136trabecula morphogenesis (GO:0061383)2.44411166
137positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.43541798
138calcium-mediated signaling using intracellular calcium source (GO:0035584)2.43343512
139L-amino acid transport (GO:0015807)2.41877761
140regulation of phospholipid biosynthetic process (GO:0071071)2.41668121
141glutamate secretion (GO:0014047)2.39733904
142neutral amino acid transport (GO:0015804)2.38901889
143regulation of positive chemotaxis (GO:0050926)2.38814969
144regulation of axon extension involved in axon guidance (GO:0048841)2.38598663
145ionotropic glutamate receptor signaling pathway (GO:0035235)2.38281233
146mitochondrion distribution (GO:0048311)2.36859842
147nucleotide transmembrane transport (GO:1901679)2.35227577
148regulation of inositol phosphate biosynthetic process (GO:0010919)2.35107569
149sodium ion export (GO:0071436)2.34432881
150dermatan sulfate metabolic process (GO:0030205)2.33893709
151negative regulation of oligodendrocyte differentiation (GO:0048715)2.33720531
152lymphangiogenesis (GO:0001946)2.33395460
153potassium ion homeostasis (GO:0055075)2.33128401
154synaptic transmission, glutamatergic (GO:0035249)2.32282919
155postsynaptic membrane organization (GO:0001941)2.31515062
156sprouting angiogenesis (GO:0002040)2.31167317
157regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.31138864
158Notch signaling involved in heart development (GO:0061314)2.30224238
159retinal ganglion cell axon guidance (GO:0031290)2.29990201
160axonal fasciculation (GO:0007413)2.29848363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.87013021
2* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.81208410
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79121766
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78931599
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.73951158
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66525638
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66308365
8GBX2_23144817_ChIP-Seq_PC3_Human2.65750778
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54503201
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54503201
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.45397923
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43949389
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30273012
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28627761
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27886836
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26791372
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25980893
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24492736
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12534179
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.11663765
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09914882
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98106870
23AR_21572438_ChIP-Seq_LNCaP_Human1.96724070
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.93374185
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92280484
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.91993388
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88197789
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.87036216
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84619857
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.79098479
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74158322
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69038330
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64409025
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.64178889
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62630549
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51062620
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51062620
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49612624
39TAF15_26573619_Chip-Seq_HEK293_Human1.46287688
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43464539
41* PIAS1_25552417_ChIP-Seq_VCAP_Human1.40554186
42DROSHA_22980978_ChIP-Seq_HELA_Human1.39333491
43P300_19829295_ChIP-Seq_ESCs_Human1.39057786
44CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38823095
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36901879
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36696499
47REST_21632747_ChIP-Seq_MESCs_Mouse1.36015243
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35552178
49ER_23166858_ChIP-Seq_MCF-7_Human1.34762113
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.34667728
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33305514
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.32386163
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30723831
54TP53_18474530_ChIP-ChIP_U2OS_Human1.30501923
55SOX9_26525672_Chip-Seq_HEART_Mouse1.29749018
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.29238110
57EWS_26573619_Chip-Seq_HEK293_Human1.29040058
58TCF4_23295773_ChIP-Seq_U87_Human1.28027113
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27139806
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26978386
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25959666
62LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25351372
63RNF2_27304074_Chip-Seq_NSC_Mouse1.24957049
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24619598
65* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23481264
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23226202
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.23162263
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21275904
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21118821
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20307474
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20251499
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.19158648
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.18043955
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.17828250
75BCAT_22108803_ChIP-Seq_LS180_Human1.16637076
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12048537
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.11755349
78* AR_25329375_ChIP-Seq_VCAP_Human1.11686538
79* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11528372
80AHR_22903824_ChIP-Seq_MCF-7_Human1.10961900
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.10593054
82SMAD3_21741376_ChIP-Seq_HESCs_Human1.10580007
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10142036
84JUN_21703547_ChIP-Seq_K562_Human1.10036890
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08864757
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08189003
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.06260207
88* TAL1_26923725_Chip-Seq_HPCs_Mouse1.06238144
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.05168440
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.04906910
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04328801
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.04234526
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04185598
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04129138
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03789670
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02807616
97RUNX2_22187159_ChIP-Seq_PCA_Human1.00267488
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99895747
99KDM2B_26808549_Chip-Seq_REH_Human0.99670544
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98819098
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98523336
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98523336
103FUS_26573619_Chip-Seq_HEK293_Human0.98366643
104RARB_27405468_Chip-Seq_BRAIN_Mouse0.97207078
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97173964
106* RXR_22108803_ChIP-Seq_LS180_Human0.96876277
107STAT3_23295773_ChIP-Seq_U87_Human0.96762885
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.96583329
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.96213877
110REST_18959480_ChIP-ChIP_MESCs_Mouse0.95983280
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95750036
112TCF4_18268006_ChIP-ChIP_LS174T_Human0.95717449
113SOX2_21211035_ChIP-Seq_LN229_Gbm0.95161247
114TP53_16413492_ChIP-PET_HCT116_Human0.94231460
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94180699
116* AR_19668381_ChIP-Seq_PC3_Human0.92963882
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91967581
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.91518755
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91180140
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90345446
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.89268335
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.89083655
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88806873
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87577171
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85343264
126* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83922001

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier4.30149627
2MP0003011_delayed_dark_adaptation3.49198755
3MP0001879_abnormal_lymphatic_vessel3.15343624
4MP0004859_abnormal_synaptic_plasticity3.01179722
5MP0003878_abnormal_ear_physiology2.67358473
6MP0005377_hearing/vestibular/ear_phenot2.67358473
7MP0003690_abnormal_glial_cell2.51705230
8MP0009384_cardiac_valve_regurgitation2.38385960
9MP0004885_abnormal_endolymph2.37472433
10MP0009379_abnormal_foot_pigmentation2.33814708
11MP0001486_abnormal_startle_reflex2.27316599
12MP0004272_abnormal_basement_membrane2.23812467
13MP0005171_absent_coat_pigmentation2.21536051
14MP0003880_abnormal_central_pattern2.18577418
15MP0005646_abnormal_pituitary_gland2.18264002
16MP0003635_abnormal_synaptic_transmissio2.11398674
17MP0001984_abnormal_olfaction2.01740487
18MP0003868_abnormal_feces_composition1.98813666
19MP0001958_emphysema1.97698776
20MP0002127_abnormal_cardiovascular_syste1.93835412
21MP0009780_abnormal_chondrocyte_physiolo1.93789710
22MP0004270_analgesia1.91762457
23MP0003633_abnormal_nervous_system1.87338361
24MP0006072_abnormal_retinal_apoptosis1.83923669
25MP0002254_reproductive_system_inflammat1.83171401
26MP0002064_seizures1.82015823
27MP0003329_amyloid_beta_deposits1.80123880
28MP0003279_aneurysm1.73074273
29MP0001188_hyperpigmentation1.72414920
30MP0005423_abnormal_somatic_nervous1.71921401
31MP0002063_abnormal_learning/memory/cond1.71322612
32MP0005623_abnormal_meninges_morphology1.70235684
33MP0009745_abnormal_behavioral_response1.67374329
34MP0002822_catalepsy1.64529239
35MP0004484_altered_response_of1.63801571
36MP0002234_abnormal_pharynx_morphology1.63157975
37MP0002735_abnormal_chemical_nociception1.62395526
38MP0002572_abnormal_emotion/affect_behav1.62200937
39MP0005248_abnormal_Harderian_gland1.60112812
40MP0001986_abnormal_taste_sensitivity1.58141655
41MP0005595_abnormal_vascular_smooth1.54860138
42MP0002009_preneoplasia1.52459372
43MP0003631_nervous_system_phenotype1.50890103
44MP0004215_abnormal_myocardial_fiber1.50595263
45MP0004147_increased_porphyrin_level1.50349633
46MP0001440_abnormal_grooming_behavior1.48104154
47MP0009046_muscle_twitch1.47704912
48MP0005409_darkened_coat_color1.47055633
49MP0005551_abnormal_eye_electrophysiolog1.46672682
50MP0005165_increased_susceptibility_to1.45563192
51MP0008569_lethality_at_weaning1.44034276
52MP0005187_abnormal_penis_morphology1.38417293
53MP0001968_abnormal_touch/_nociception1.37537801
54MP0006292_abnormal_olfactory_placode1.37109043
55MP0005084_abnormal_gallbladder_morpholo1.36995597
56MP0009697_abnormal_copulation1.33810082
57MP0000778_abnormal_nervous_system1.33476715
58MP0002734_abnormal_mechanical_nocicepti1.32427482
59MP0000566_synostosis1.30144562
60MP0002557_abnormal_social/conspecific_i1.28071252
61MP0001502_abnormal_circadian_rhythm1.27610690
62MP0010368_abnormal_lymphatic_system1.25274344
63MP0006138_congestive_heart_failure1.22851645
64MP0005253_abnormal_eye_physiology1.22595667
65MP0002295_abnormal_pulmonary_circulatio1.21398197
66MP0009278_abnormal_bone_marrow1.21296139
67MP0001485_abnormal_pinna_reflex1.21254860
68MP0001501_abnormal_sleep_pattern1.20914546
69MP0002272_abnormal_nervous_system1.20850394
70MP0002736_abnormal_nociception_after1.20775301
71MP0001905_abnormal_dopamine_level1.20214079
72MP0000049_abnormal_middle_ear1.19331059
73MP0002249_abnormal_larynx_morphology1.18439148
74MP0000462_abnormal_digestive_system1.18348184
75MP0005391_vision/eye_phenotype1.17862150
76MP0004019_abnormal_vitamin_homeostasis1.16979273
77MP0004924_abnormal_behavior1.14971783
78MP0005386_behavior/neurological_phenoty1.14971783
79MP0003634_abnormal_glial_cell1.12952716
80MP0006276_abnormal_autonomic_nervous1.11869933
81MP0000613_abnormal_salivary_gland1.10104266
82MP0008789_abnormal_olfactory_epithelium1.08185808
83MP0001346_abnormal_lacrimal_gland1.08056845
84MP0002108_abnormal_muscle_morphology1.07748056
85MP0004883_abnormal_blood_vessel1.07686178
86MP0005195_abnormal_posterior_eye1.06659850
87MP0005367_renal/urinary_system_phenotyp1.06652124
88MP0000516_abnormal_urinary_system1.06652124
89MP0002752_abnormal_somatic_nervous1.06602380
90MP0001529_abnormal_vocalization1.05669607
91MP0001963_abnormal_hearing_physiology1.05484049
92MP0003122_maternal_imprinting1.04455326
93MP0004858_abnormal_nervous_system1.04310582
94MP0004142_abnormal_muscle_tone1.03200939
95MP0004085_abnormal_heartbeat1.01693017
96MP0002638_abnormal_pupillary_reflex1.01139627
97MP0000631_abnormal_neuroendocrine_gland1.01011011
98MP0003137_abnormal_impulse_conducting1.00907859
99MP0000534_abnormal_ureter_morphology1.00162961
100MP0002066_abnormal_motor_capabilities/c0.98897335
101MP0002733_abnormal_thermal_nociception0.98630900
102MP0002067_abnormal_sensory_capabilities0.98470931
103MP0003787_abnormal_imprinting0.98026154
104MP0000013_abnormal_adipose_tissue0.97297684
105MP0000249_abnormal_blood_vessel0.94983859
106MP0003632_abnormal_nervous_system0.94888121
107MP0009250_abnormal_appendicular_skeleto0.93546995
108MP0002090_abnormal_vision0.91954644
109MP0003136_yellow_coat_color0.90224170
110MP0005499_abnormal_olfactory_system0.90078196
111MP0005394_taste/olfaction_phenotype0.90078196
112MP0008004_abnormal_stomach_pH0.89892645
113MP0002972_abnormal_cardiac_muscle0.88612105
114MP0000920_abnormal_myelination0.88561730
115MP0002233_abnormal_nose_morphology0.87012229
116MP0005164_abnormal_response_to0.86092068
117MP0001970_abnormal_pain_threshold0.85164219
118MP0004811_abnormal_neuron_physiology0.83263045
119MP0002152_abnormal_brain_morphology0.82602084
120MP0001177_atelectasis0.82430099
121MP0002184_abnormal_innervation0.82200885
122MP0002928_abnormal_bile_duct0.81650971
123MP0000026_abnormal_inner_ear0.81518584
124MP0003638_abnormal_response/metabolism_0.81432832
125MP0003937_abnormal_limbs/digits/tail_de0.81206421
126MP0009053_abnormal_anal_canal0.80407594
127MP0002882_abnormal_neuron_morphology0.80277175
128MP0002332_abnormal_exercise_endurance0.79350842
129MP0000537_abnormal_urethra_morphology0.79160046
130MP0000955_abnormal_spinal_cord0.78309175
131MP0000372_irregular_coat_pigmentation0.77849909
132MP0002229_neurodegeneration0.77223628
133MP0001873_stomach_inflammation0.76856370
134MP0004742_abnormal_vestibular_system0.76653058
135MP0003075_altered_response_to0.76524652
136MP0003119_abnormal_digestive_system0.75162858
137MP0005620_abnormal_muscle_contractility0.73918707
138MP0003938_abnormal_ear_development0.73786541
139MP0000538_abnormal_urinary_bladder0.68565994
140MP0000647_abnormal_sebaceous_gland0.66552445
141MP0000579_abnormal_nail_morphology0.65231723
142MP0004043_abnormal_pH_regulation0.63613547

Predicted human phenotypes

RankGene SetZ-score
1Hemiparesis (HP:0001269)6.09651999
2Aplasia involving bones of the upper limbs (HP:0009823)5.55161079
3Aplasia of the phalanges of the hand (HP:0009802)5.55161079
4Aplasia involving bones of the extremities (HP:0009825)5.55161079
5Abnormality of secondary sexual hair (HP:0009888)5.22733454
6Abnormality of the axillary hair (HP:0100134)5.22733454
7Onycholysis (HP:0001806)5.20556390
8Adactyly (HP:0009776)4.96894431
9Diplopia (HP:0000651)4.90586484
10Abnormality of binocular vision (HP:0011514)4.90586484
11Megalencephaly (HP:0001355)4.26775309
12Neurofibrillary tangles (HP:0002185)3.77877976
13Epileptic encephalopathy (HP:0200134)3.47044225
14Hypoglycemic seizures (HP:0002173)3.46554628
15Confusion (HP:0001289)3.30610981
16Hypoplastic left heart (HP:0004383)3.23406580
17Hypoglycemic coma (HP:0001325)3.22347624
18Focal motor seizures (HP:0011153)3.19700407
19Broad-based gait (HP:0002136)3.11333045
20Hemiplegia (HP:0002301)3.10914756
21Drooling (HP:0002307)3.09800457
22Abnormality of permanent molar morphology (HP:0011071)3.07041028
23Abnormality of the dental root (HP:0006486)3.07041028
24Taurodontia (HP:0000679)3.07041028
25Hyperinsulinemic hypoglycemia (HP:0000825)3.04548016
26Abnormality of the dental pulp (HP:0006479)3.04445801
27Hepatoblastoma (HP:0002884)3.02324892
28Gait imbalance (HP:0002141)2.97521341
29Portal hypertension (HP:0001409)2.96870444
30Stomach cancer (HP:0012126)2.95581736
31Hypoalphalipoproteinemia (HP:0003233)2.92477354
32Poor eye contact (HP:0000817)2.89075030
33Colon cancer (HP:0003003)2.87125005
34Abnormality of molar (HP:0011077)2.85265286
35Abnormality of molar morphology (HP:0011070)2.85265286
36Absent hand (HP:0004050)2.85195725
37Excessive salivation (HP:0003781)2.84816873
38Pancreatic islet-cell hyperplasia (HP:0004510)2.84527001
39Febrile seizures (HP:0002373)2.83383701
40Exercise-induced muscle cramps (HP:0003710)2.79570408
41Neoplasm of the oral cavity (HP:0100649)2.75283989
42Aplasia/Hypoplasia of the hallux (HP:0008362)2.73888396
43Vascular calcification (HP:0004934)2.73763437
44Chronic hepatic failure (HP:0100626)2.73374004
45Hyperphosphatemia (HP:0002905)2.72417393
46Epidermoid cyst (HP:0200040)2.71977963
47Short hallux (HP:0010109)2.68793401
48Abnormality of the hepatic vasculature (HP:0006707)2.66736762
49Focal seizures (HP:0007359)2.64983451
50Cerebral inclusion bodies (HP:0100314)2.61478474
51Protruding tongue (HP:0010808)2.60165911
52True hermaphroditism (HP:0010459)2.58631555
53Abnormality of renal resorption (HP:0011038)2.57536274
54Increased CSF protein (HP:0002922)2.56837090
55Ulnar claw (HP:0001178)2.55249656
56Congenital primary aphakia (HP:0007707)2.52468498
57Medial flaring of the eyebrow (HP:0010747)2.51506167
58Esophageal varix (HP:0002040)2.50828594
59Neoplasm of the adrenal cortex (HP:0100641)2.50318178
60Nephrogenic diabetes insipidus (HP:0009806)2.48757757
61Clumsiness (HP:0002312)2.45779275
62Hypoplasia of the uterus (HP:0000013)2.44770522
63Subacute progressive viral hepatitis (HP:0006572)2.44368449
64Medulloblastoma (HP:0002885)2.43443691
65Hypoplastic heart (HP:0001961)2.42917140
66Genital tract atresia (HP:0001827)2.41872596
67Status epilepticus (HP:0002133)2.40597707
68Abnormality of nail color (HP:0100643)2.39822664
69Tubulointerstitial nephritis (HP:0001970)2.39722757
70Hyperventilation (HP:0002883)2.37793564
71Abnormal social behavior (HP:0012433)2.36870860
72Impaired social interactions (HP:0000735)2.36870860
73Cardiovascular calcification (HP:0011915)2.35425210
74Symptomatic seizures (HP:0011145)2.34122344
75Papillary thyroid carcinoma (HP:0002895)2.34105458
76Vascular tortuosity (HP:0004948)2.32932322
77Absent toe (HP:0010760)2.31069162
78Myokymia (HP:0002411)2.29870357
79Aplasia/Hypoplasia of the spleen (HP:0010451)2.28886587
80Dysdiadochokinesis (HP:0002075)2.28703070
81Vaginal atresia (HP:0000148)2.28655511
82Absent hair (HP:0002298)2.28121377
83Annular pancreas (HP:0001734)2.23759268
84Cranial hyperostosis (HP:0004437)2.23388936
85Glioma (HP:0009733)2.21830832
86Cone-rod dystrophy (HP:0000548)2.21563876
87Inability to walk (HP:0002540)2.21076553
88Mixed hearing impairment (HP:0000410)2.20922396
89Abnormality of the astrocytes (HP:0100707)2.19052862
90Astrocytoma (HP:0009592)2.19052862
91Keratoconus (HP:0000563)2.18092620
92Increased corneal curvature (HP:0100692)2.18092620
93Dialeptic seizures (HP:0011146)2.15863356
94Abnormal eating behavior (HP:0100738)2.14352589
95Arterial tortuosity (HP:0005116)2.13136293
96Abnormality of the middle phalanges of the toes (HP:0010183)2.11382710
97Absent speech (HP:0001344)2.09140253
98Tetraplegia (HP:0002445)2.08222947
99Decreased central vision (HP:0007663)2.08091393
100Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07258879
101Capillary hemangiomas (HP:0005306)2.04349178
102Intellectual disability, severe (HP:0010864)2.03785573
103Choroideremia (HP:0001139)2.03407885
104Broad foot (HP:0001769)2.01799636
105Aplasia/hypoplasia of the uterus (HP:0008684)2.00832626
106Polycythemia (HP:0001901)1.99346654
107Long nose (HP:0003189)1.99337429
108Retinal dysplasia (HP:0007973)1.96965368
109Abnormality of renal excretion (HP:0011036)1.95363762
110Absent/shortened dynein arms (HP:0200106)1.95331730
111Dynein arm defect of respiratory motile cilia (HP:0012255)1.95331730
112Fibular aplasia (HP:0002990)1.95309410
113Absence seizures (HP:0002121)1.95042196
114Polyphagia (HP:0002591)1.94403576
115Preaxial foot polydactyly (HP:0001841)1.93591556
116Type II lissencephaly (HP:0007260)1.90757049
117Limb dystonia (HP:0002451)1.89365458
118Ankle clonus (HP:0011448)1.88352453
119Palpebral edema (HP:0100540)1.87792682
120Stereotypic behavior (HP:0000733)1.87698692
121Optic nerve hypoplasia (HP:0000609)1.87398186
122Supranuclear gaze palsy (HP:0000605)1.86750601
123Postural tremor (HP:0002174)1.86442553
124Menstrual irregularities (HP:0000858)1.86001957
125Postural instability (HP:0002172)1.81068225
126Truncal ataxia (HP:0002078)1.80631037
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80072410
128Pancreatic fibrosis (HP:0100732)1.79618035
129Abnormality of the aortic arch (HP:0012303)1.79547904
130Gaze-evoked nystagmus (HP:0000640)1.79499289
131Alacrima (HP:0000522)1.79024717
132Chorioretinal atrophy (HP:0000533)1.78388304
133Large earlobe (HP:0009748)1.77865849
134Craniofacial hyperostosis (HP:0004493)1.77430785
135Hamartoma (HP:0010566)1.76859071
136Atonic seizures (HP:0010819)1.76014149
137Spastic tetraparesis (HP:0001285)1.75758621
138Pseudobulbar signs (HP:0002200)1.75630247
139Agitation (HP:0000713)1.75591580
140Acanthosis nigricans (HP:0000956)1.75396213
141Stenosis of the external auditory canal (HP:0000402)1.75395465
142Peripheral hypomyelination (HP:0007182)1.73965195
143Retinal atrophy (HP:0001105)1.73548409
144Hypoplasia of the corpus callosum (HP:0002079)1.72217522
145Broad alveolar ridges (HP:0000187)1.71768023
146Hypoplasia of dental enamel (HP:0006297)1.70851540
147Attenuation of retinal blood vessels (HP:0007843)1.70490737
148Dyskinesia (HP:0100660)1.70409408
149Prolonged QT interval (HP:0001657)1.70190617
150Congenital stationary night blindness (HP:0007642)1.68905781
151Pachygyria (HP:0001302)1.67321207
152Thickened helices (HP:0000391)1.67313041
153Humeroradial synostosis (HP:0003041)1.66019915
154Synostosis involving the elbow (HP:0003938)1.66019915
155Mutism (HP:0002300)1.65121394
156Gastroesophageal reflux (HP:0002020)1.63981846
157Specific learning disability (HP:0001328)1.63965698
158Abnormality of salivation (HP:0100755)1.63780719
159Abnormality of the ischium (HP:0003174)1.63439755
160Vitreoretinal degeneration (HP:0000655)1.63304945
161Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.63226171
162Generalized tonic-clonic seizures (HP:0002069)1.61989527
163Bronchomalacia (HP:0002780)1.61864990
164Progressive cerebellar ataxia (HP:0002073)1.61633715
165Gastrointestinal atresia (HP:0002589)1.61411559
166Axonal loss (HP:0003447)1.61023113
167Supernumerary spleens (HP:0009799)1.60667362
168Tetraparesis (HP:0002273)1.59613143
169Split foot (HP:0001839)1.58307481
170Subcapsular cataract (HP:0000523)1.57146565
171Visual hallucinations (HP:0002367)1.56757075
172Action tremor (HP:0002345)1.56345981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.91984164
2KDR4.41121600
3MUSK4.27287720
4EPHA43.95187475
5GRK13.62381576
6NTRK23.13526279
7TNIK2.80705293
8INSRR2.77660149
9CASK2.73876201
10WNK32.20332615
11PHKG22.12458356
12PHKG12.12458356
13NTRK31.90453384
14FRK1.90226961
15CSNK1A1L1.85778393
16CSNK1G31.70152234
17PTK61.63765076
18CSNK1G11.57769524
19PTK2B1.48286962
20STK391.47377183
21LMTK21.41467856
22MARK11.39655085
23RAF11.38938794
24DMPK1.34581246
25PINK11.32858880
26NLK1.32794166
27WEE11.32492835
28MAPK121.30217624
29MST41.29995817
30FGR1.24018493
31AKT31.23328218
32MAP4K21.18715133
33PRKCE1.16536423
34ROCK11.13499189
35NTRK11.12362217
36UHMK11.10102238
37FES1.07662335
38FGFR21.07575086
39PRKCG1.04181334
40NUAK11.03452951
41MAPK71.01874300
42MINK11.01224398
43PRPF4B1.00099547
44MAP3K40.99185900
45MAPK130.94514570
46PRKD30.91008955
47EPHA30.90493108
48PRKG20.88974303
49TRIB30.88950254
50PRKAA20.88709084
51IGF1R0.88220050
52CDK50.87269049
53MELK0.86495605
54MKNK20.86289051
55STK38L0.82715510
56CAMKK10.81545002
57DYRK20.80606980
58PRKCQ0.80589356
59MAP2K70.80110493
60KSR10.78456828
61CAMK1G0.77469671
62GRK50.75143192
63CAMK2A0.74429593
64MAPK150.73243352
65WNK40.71826562
66EPHB20.71615049
67SGK4940.69826361
68SGK2230.69826361
69MAP3K90.69616849
70PAK60.66912076
71MARK20.66081409
72PRKCH0.63660063
73INSR0.62891189
74BMX0.62509215
75PRKG10.61078563
76TGFBR20.60783229
77PNCK0.60747148
78SGK20.60458776
79DAPK20.58836767
80IRAK30.58269895
81CCNB10.58231799
82CSNK1G20.58185669
83MAP2K20.56217838
84CSNK1A10.55773281
85WNK10.55527701
86STK110.55224309
87RIPK40.54292257
88RET0.54016052
89SRC0.53826914
90MAPKAPK50.53687322
91OXSR10.52990362
92CAMK10.52940133
93MAP2K10.52591456
94PBK0.52418614
95BMPR1B0.50852215
96ADRBK10.50687845
97PRKCA0.50403398
98TYRO30.50247254
99DYRK1A0.49886158
100CAMK2G0.48485650
101MAPK40.48096125
102EPHB10.47840944
103CAMK2D0.46631827
104PDPK10.45984792
105SGK10.45333318
106PAK30.44253998
107PRKCZ0.42405212
108BRSK20.42157568
109BMPR20.41877230
110PRKACA0.41858764
111GSK3A0.41010721
112CAMK2B0.40958053
113SIK20.40257383
114KSR20.39954531
115TSSK60.39940844
116PRKD10.39358892
117VRK10.39213236
118TEC0.37698371
119NEK90.37266885
120PRKAA10.36854698
121PKN10.36556393
122MAP3K120.36350894
123SIK10.36139802
124CSNK1D0.35703211
125RPS6KA30.35676507
126PRKACG0.33021393
127PLK20.32748011
128FYN0.32012973
129ERBB40.31891085
130NEK60.31859078
131CDK30.31375899
132MAPK100.30943833
133ROCK20.29910477
134EIF2AK10.29582405
135PRKDC0.29398308
136ERBB20.29070091
137FER0.28440847
138EIF2AK20.27788979
139SGK30.25988269
140BRSK10.25824835
141VRK20.24552878

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.17817655
2Fatty acid biosynthesis_Homo sapiens_hsa000612.71176551
3Nicotine addiction_Homo sapiens_hsa050332.39038186
4GABAergic synapse_Homo sapiens_hsa047272.32218574
5Glutamatergic synapse_Homo sapiens_hsa047242.27365354
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24175053
7Bile secretion_Homo sapiens_hsa049762.08679315
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00992101
9Mineral absorption_Homo sapiens_hsa049781.91988358
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87301311
11Morphine addiction_Homo sapiens_hsa050321.82030738
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80999579
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76372687
14Gastric acid secretion_Homo sapiens_hsa049711.71637165
15Circadian entrainment_Homo sapiens_hsa047131.70618208
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.69008612
17Salivary secretion_Homo sapiens_hsa049701.68150051
18Insulin secretion_Homo sapiens_hsa049111.61203271
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52669525
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51321728
21Fatty acid metabolism_Homo sapiens_hsa012121.41592405
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37431535
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36047675
24Fatty acid elongation_Homo sapiens_hsa000621.34589309
25Cocaine addiction_Homo sapiens_hsa050301.32962005
26Long-term depression_Homo sapiens_hsa047301.31237598
27Serotonergic synapse_Homo sapiens_hsa047261.30403862
28Phototransduction_Homo sapiens_hsa047441.30171201
29Dorso-ventral axis formation_Homo sapiens_hsa043201.29270092
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26880188
31Vitamin B6 metabolism_Homo sapiens_hsa007501.25208742
32Calcium signaling pathway_Homo sapiens_hsa040201.19672360
33Vitamin digestion and absorption_Homo sapiens_hsa049771.19588053
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17474690
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17338288
36Histidine metabolism_Homo sapiens_hsa003401.17049573
37Ether lipid metabolism_Homo sapiens_hsa005651.16962872
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15831789
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15709395
40Cholinergic synapse_Homo sapiens_hsa047251.15538257
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15359638
42Amphetamine addiction_Homo sapiens_hsa050311.13565419
43Long-term potentiation_Homo sapiens_hsa047201.08960383
44Olfactory transduction_Homo sapiens_hsa047401.08860629
45Axon guidance_Homo sapiens_hsa043601.07931410
46Sphingolipid metabolism_Homo sapiens_hsa006001.06795601
47Melanogenesis_Homo sapiens_hsa049161.04401569
48Renin secretion_Homo sapiens_hsa049241.03918457
49Rap1 signaling pathway_Homo sapiens_hsa040151.03455781
50Arginine and proline metabolism_Homo sapiens_hsa003301.03436580
51Butanoate metabolism_Homo sapiens_hsa006501.03119849
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.01089026
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97482415
54Gap junction_Homo sapiens_hsa045400.97371111
55Dopaminergic synapse_Homo sapiens_hsa047280.95577648
56Taste transduction_Homo sapiens_hsa047420.95549850
57PPAR signaling pathway_Homo sapiens_hsa033200.94411624
58African trypanosomiasis_Homo sapiens_hsa051430.93640005
59Adherens junction_Homo sapiens_hsa045200.88417369
60cAMP signaling pathway_Homo sapiens_hsa040240.88098590
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85318181
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84879755
63Fatty acid degradation_Homo sapiens_hsa000710.84552901
64Pancreatic secretion_Homo sapiens_hsa049720.84077026
65Ras signaling pathway_Homo sapiens_hsa040140.83052937
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82266094
67Ovarian steroidogenesis_Homo sapiens_hsa049130.81280977
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.80329035
69Oxytocin signaling pathway_Homo sapiens_hsa049210.79077112
70Choline metabolism in cancer_Homo sapiens_hsa052310.78514086
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78238118
72beta-Alanine metabolism_Homo sapiens_hsa004100.77771358
73Steroid biosynthesis_Homo sapiens_hsa001000.76944394
74Arginine biosynthesis_Homo sapiens_hsa002200.74297568
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.73599502
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.73083811
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.72793028
78Estrogen signaling pathway_Homo sapiens_hsa049150.71606252
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71482448
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71344657
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70627453
82Focal adhesion_Homo sapiens_hsa045100.65349113
83HIF-1 signaling pathway_Homo sapiens_hsa040660.64576226
84Cardiac muscle contraction_Homo sapiens_hsa042600.64532917
85Basal cell carcinoma_Homo sapiens_hsa052170.63684424
86Dilated cardiomyopathy_Homo sapiens_hsa054140.63363844
87Rheumatoid arthritis_Homo sapiens_hsa053230.62815074
88Renal cell carcinoma_Homo sapiens_hsa052110.62421159
89Wnt signaling pathway_Homo sapiens_hsa043100.61339328
90Thyroid hormone synthesis_Homo sapiens_hsa049180.60946981
91Circadian rhythm_Homo sapiens_hsa047100.60438259
92Sulfur relay system_Homo sapiens_hsa041220.60194647
93Peroxisome_Homo sapiens_hsa041460.59777266
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.58103823
95GnRH signaling pathway_Homo sapiens_hsa049120.57418784
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57016523
97Protein digestion and absorption_Homo sapiens_hsa049740.56854409
98ABC transporters_Homo sapiens_hsa020100.56647131
99Prion diseases_Homo sapiens_hsa050200.55997927
100Tight junction_Homo sapiens_hsa045300.54050910
101Starch and sucrose metabolism_Homo sapiens_hsa005000.53660593
102Synaptic vesicle cycle_Homo sapiens_hsa047210.52739354
103Propanoate metabolism_Homo sapiens_hsa006400.51139434
104Folate biosynthesis_Homo sapiens_hsa007900.50812392
105Glycerolipid metabolism_Homo sapiens_hsa005610.50802857
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50490911
107Endometrial cancer_Homo sapiens_hsa052130.47984387
108Glucagon signaling pathway_Homo sapiens_hsa049220.47490800
109Retinol metabolism_Homo sapiens_hsa008300.45812897
110Glioma_Homo sapiens_hsa052140.45762310
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44567839
112* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44223962
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43677230
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43064692
115ECM-receptor interaction_Homo sapiens_hsa045120.41522429
116ErbB signaling pathway_Homo sapiens_hsa040120.40479468
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.38721631
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38313792
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.37897002
120Hippo signaling pathway_Homo sapiens_hsa043900.37527527
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36777220
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36676077
123Hedgehog signaling pathway_Homo sapiens_hsa043400.36050956
124Linoleic acid metabolism_Homo sapiens_hsa005910.35754103
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35506247
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34600074
127Regulation of autophagy_Homo sapiens_hsa041400.33587468

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