SLCO2B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.60861963
2L-phenylalanine catabolic process (GO:0006559)6.60861963
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.30013542
4L-phenylalanine metabolic process (GO:0006558)6.30013542
5aromatic amino acid family catabolic process (GO:0009074)5.97099960
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.72917604
7indole-containing compound catabolic process (GO:0042436)5.41271109
8indolalkylamine catabolic process (GO:0046218)5.41271109
9tryptophan catabolic process (GO:0006569)5.41271109
10urea metabolic process (GO:0019627)5.33776791
11urea cycle (GO:0000050)5.33776791
12alpha-linolenic acid metabolic process (GO:0036109)5.33239811
13bile acid biosynthetic process (GO:0006699)5.26863765
14complement activation, alternative pathway (GO:0006957)5.23185151
15kynurenine metabolic process (GO:0070189)5.20992190
16protein carboxylation (GO:0018214)5.19639419
17peptidyl-glutamic acid carboxylation (GO:0017187)5.19639419
18tryptophan metabolic process (GO:0006568)5.13863463
19regulation of protein activation cascade (GO:2000257)5.02235472
20nitrogen cycle metabolic process (GO:0071941)4.91192038
21high-density lipoprotein particle remodeling (GO:0034375)4.91087031
22glyoxylate metabolic process (GO:0046487)4.86515825
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86444677
24negative regulation of fibrinolysis (GO:0051918)4.86029957
25regulation of complement activation (GO:0030449)4.75931218
26sulfur amino acid catabolic process (GO:0000098)4.73518684
27regulation of fibrinolysis (GO:0051917)4.72643101
28bile acid metabolic process (GO:0008206)4.68324029
29regulation of triglyceride catabolic process (GO:0010896)4.54847110
30reverse cholesterol transport (GO:0043691)4.51680000
31cysteine metabolic process (GO:0006534)4.49348278
32phospholipid efflux (GO:0033700)4.45992775
33regulation of cholesterol esterification (GO:0010872)4.35122953
34serine family amino acid catabolic process (GO:0009071)4.28887538
35aromatic amino acid family metabolic process (GO:0009072)4.28203189
36acylglycerol homeostasis (GO:0055090)4.26185145
37triglyceride homeostasis (GO:0070328)4.26185145
38glycosphingolipid catabolic process (GO:0046479)4.23271036
39tyrosine metabolic process (GO:0006570)4.22249550
40protein-lipid complex remodeling (GO:0034368)4.18515049
41macromolecular complex remodeling (GO:0034367)4.18515049
42plasma lipoprotein particle remodeling (GO:0034369)4.18515049
43homocysteine metabolic process (GO:0050667)4.18484872
44epoxygenase P450 pathway (GO:0019373)4.16885463
45complement activation, classical pathway (GO:0006958)4.15371226
46regulation of macrophage chemotaxis (GO:0010758)4.09792705
47complement activation (GO:0006956)4.06599816
48plasma lipoprotein particle clearance (GO:0034381)4.06349480
49* bile acid and bile salt transport (GO:0015721)4.05075742
50negative regulation of sterol transport (GO:0032372)4.01161077
51negative regulation of cholesterol transport (GO:0032375)4.01161077
52lysine catabolic process (GO:0006554)4.00867207
53lysine metabolic process (GO:0006553)4.00867207
54alpha-amino acid catabolic process (GO:1901606)4.00613939
55amino-acid betaine metabolic process (GO:0006577)3.99997857
56cholesterol efflux (GO:0033344)3.97209851
57regulation of apoptotic cell clearance (GO:2000425)3.90306358
58negative regulation of lipase activity (GO:0060192)3.89783434
59cellular biogenic amine catabolic process (GO:0042402)3.88634581
60amine catabolic process (GO:0009310)3.88634581
61phospholipid homeostasis (GO:0055091)3.86063788
62cellular ketone body metabolic process (GO:0046950)3.85017720
63positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.84883346
64glycolipid catabolic process (GO:0019377)3.84587225
65fat-soluble vitamin biosynthetic process (GO:0042362)3.83734338
66indolalkylamine metabolic process (GO:0006586)3.81165123
67protein activation cascade (GO:0072376)3.80556378
68cellular modified amino acid catabolic process (GO:0042219)3.78882267
69cellular glucuronidation (GO:0052695)3.78009608
70fibrinolysis (GO:0042730)3.75022494
71regulation of mononuclear cell migration (GO:0071675)3.74142510
72coenzyme catabolic process (GO:0009109)3.73309127
73plasma lipoprotein particle assembly (GO:0034377)3.73116517
74cellular amino acid catabolic process (GO:0009063)3.72497247
75oligosaccharide catabolic process (GO:0009313)3.66110378
76glutamate metabolic process (GO:0006536)3.65777266
77ethanol oxidation (GO:0006069)3.65759012
78imidazole-containing compound metabolic process (GO:0052803)3.64161015
79positive regulation of lipid catabolic process (GO:0050996)3.60673993
80omega-hydroxylase P450 pathway (GO:0097267)3.57486632
81low-density lipoprotein particle remodeling (GO:0034374)3.56880897
82benzene-containing compound metabolic process (GO:0042537)3.54373192
83protein-lipid complex assembly (GO:0065005)3.53144112
84cholesterol homeostasis (GO:0042632)3.50800644
85arginine metabolic process (GO:0006525)3.48520184
86drug catabolic process (GO:0042737)3.48088687
87cytolysis (GO:0019835)3.47784759
88dicarboxylic acid biosynthetic process (GO:0043650)3.47173350
89sterol homeostasis (GO:0055092)3.45708022
90positive regulation of chemokine secretion (GO:0090197)3.42908576
91exogenous drug catabolic process (GO:0042738)3.41284276
92blood coagulation, intrinsic pathway (GO:0007597)3.39574423
93positive regulation of fatty acid beta-oxidation (GO:0032000)3.39528161
94N-acetylneuraminate metabolic process (GO:0006054)3.39369713
95glycine metabolic process (GO:0006544)3.39222758
96positive regulation of triglyceride lipase activity (GO:0061365)3.38189246
97positive regulation of lipoprotein lipase activity (GO:0051006)3.38189246
98short-chain fatty acid metabolic process (GO:0046459)3.36971526
99organic acid catabolic process (GO:0016054)3.36125646
100carboxylic acid catabolic process (GO:0046395)3.36125646
101ceramide catabolic process (GO:0046514)3.35662137
102virion attachment to host cell (GO:0019062)3.32985691
103adhesion of symbiont to host cell (GO:0044650)3.32985691
104glucuronate metabolic process (GO:0019585)3.32931306
105uronic acid metabolic process (GO:0006063)3.32931306
106cellular response to thyroid hormone stimulus (GO:0097067)3.30705426
107ketone body metabolic process (GO:1902224)3.29692382
108plasma lipoprotein particle organization (GO:0071827)3.29463094
109acetyl-CoA metabolic process (GO:0006084)3.27785569
110serine family amino acid metabolic process (GO:0009069)3.26092871
111regulation of bile acid biosynthetic process (GO:0070857)3.25497491
112monocarboxylic acid catabolic process (GO:0072329)3.25284979
113cofactor catabolic process (GO:0051187)3.25176139
114macrophage activation involved in immune response (GO:0002281)3.24381841
115fatty acid oxidation (GO:0019395)3.23233951
116flavonoid metabolic process (GO:0009812)3.23052802
117fatty acid beta-oxidation (GO:0006635)3.22061755
118regulation of hypersensitivity (GO:0002883)3.21780833
119adenosine receptor signaling pathway (GO:0001973)3.21690821
120lipoprotein metabolic process (GO:0042157)3.21380544
121adhesion of symbiont to host (GO:0044406)3.20656618
122cellular response to ethanol (GO:0071361)3.19192904
123amino sugar catabolic process (GO:0046348)3.17592018
124detection of molecule of bacterial origin (GO:0032490)3.10629267
125apoptotic cell clearance (GO:0043277)3.07194107
126protein-lipid complex subunit organization (GO:0071825)3.07067994
127angiotensin maturation (GO:0002003)3.06630988
128very-low-density lipoprotein particle assembly (GO:0034379)3.05900602
129positive regulation of phagocytosis (GO:0050766)3.05129334
130positive regulation of cholesterol efflux (GO:0010875)3.04380166
131regulation of cholesterol storage (GO:0010885)3.00476305
132positive regulation of cellular amide metabolic process (GO:0034250)2.98376934
133regulation of chemokine secretion (GO:0090196)2.98042383
134regulation of myeloid leukocyte mediated immunity (GO:0002886)2.90260155
135positive regulation of cholesterol transport (GO:0032376)2.88913887
136positive regulation of sterol transport (GO:0032373)2.88913887
137response to thyroid hormone (GO:0097066)2.84930234
138cellular response to cadmium ion (GO:0071276)2.83491825
139positive regulation of fatty acid biosynthetic process (GO:0045723)2.82485483
140acute-phase response (GO:0006953)2.82043473
141negative regulation of hemostasis (GO:1900047)2.79779331
142negative regulation of blood coagulation (GO:0030195)2.79779331
143barbed-end actin filament capping (GO:0051016)2.76788871
144negative regulation of interleukin-12 production (GO:0032695)2.73262765
145positive regulation of antigen processing and presentation (GO:0002579)2.72801470
146positive regulation of mast cell activation involved in immune response (GO:0033008)2.67778564
147positive regulation of mast cell degranulation (GO:0043306)2.67778564
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67694685
149regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.66988766
150hydrogen peroxide biosynthetic process (GO:0050665)2.66425159
151mannose metabolic process (GO:0006013)2.65778758
152drug metabolic process (GO:0017144)2.64811430
153immunoglobulin mediated immune response (GO:0016064)2.64712630
154positive regulation of leukocyte degranulation (GO:0043302)2.63808950
155negative regulation of granulocyte differentiation (GO:0030853)2.63094960
156negative regulation of coagulation (GO:0050819)2.61770852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.69798296
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.98950883
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.07591113
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.73472016
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.49105104
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.63087806
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.55097334
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.73918023
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.67673101
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.83850337
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26119883
12GATA1_22025678_ChIP-Seq_K562_Human1.98370033
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87645890
14CLOCK_20551151_ChIP-Seq_293T_Human1.81742717
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78618081
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78613677
17* SPI1_23127762_ChIP-Seq_K562_Human1.74293168
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.68089686
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65606706
20* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61179095
21* IRF8_27001747_Chip-Seq_BMDM_Mouse1.59657112
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55007087
23VDR_24763502_ChIP-Seq_THP-1_Human1.52829721
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52789879
25* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51673737
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50458058
27* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45056734
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38321344
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34678738
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27752456
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27151451
32DROSHA_22980978_ChIP-Seq_HELA_Human1.27145338
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25942734
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.25418223
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24386741
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22684184
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.21933659
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21660433
39* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18722603
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18057621
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16527171
42VDR_21846776_ChIP-Seq_THP-1_Human1.15451333
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.11135594
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10719561
45SCL_19346495_ChIP-Seq_HPC-7_Human1.10473275
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07695924
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03658015
48SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98223594
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97325401
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97018693
51ELK3_25401928_ChIP-Seq_HUVEC_Human0.96973783
52RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95580272
53CDX2_20551321_ChIP-Seq_CACO-2_Human0.95261368
54ESR1_21235772_ChIP-Seq_MCF-7_Human0.95247230
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94587638
56STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93940320
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93403288
58IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92192844
59* KDM2B_26808549_Chip-Seq_K562_Human0.91814148
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91757542
61GATA2_21666600_ChIP-Seq_HMVEC_Human0.90685721
62SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90535648
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89703050
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89663073
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89569378
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89407744
67SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88905929
68RUNX1_22412390_ChIP-Seq_EML_Mouse0.88684566
69HTT_18923047_ChIP-ChIP_STHdh_Human0.87741079
70RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87727046
71SPI1_23547873_ChIP-Seq_NB4_Human0.87215773
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86975621
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86621717
74ERG_21242973_ChIP-ChIP_JURKAT_Human0.86312752
75* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85916650
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84701983
77* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83896560
78BCL6_27268052_Chip-Seq_Bcells_Human0.83271570
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83122344
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82908773
81RUNX_20019798_ChIP-Seq_JUKART_Human0.82717945
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82375665
83* GATA2_19941826_ChIP-Seq_K562_Human0.81597496
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81097221
85PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81094725
86* GATA1_19941826_ChIP-Seq_K562_Human0.80608384
87BCOR_27268052_Chip-Seq_Bcells_Human0.79439243
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78291535
89* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78046478
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77742498
91* LXR_22292898_ChIP-Seq_THP-1_Human0.77616058
92FOXO3_23340844_ChIP-Seq_DLD1_Human0.77114166
93VDR_24787735_ChIP-Seq_THP-1_Human0.76251262
94BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74821556
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74531206
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74531206
97* GATA1_19941827_ChIP-Seq_MEL_Mouse0.73217763
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73177073
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72740923
100* GATA4_25053715_ChIP-Seq_YYC3_Human0.71711830
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.69962998
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69941979
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69358582
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67606111
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67222714
106NFIB_24661679_ChIP-Seq_LUNG_Mouse0.66534246
107ZNF263_19887448_ChIP-Seq_K562_Human0.64574038
108EGR1_19032775_ChIP-ChIP_M12_Human0.63738005
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.62787620
110SOX2_20726797_ChIP-Seq_SW620_Human0.62272902
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.61581390
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.60359025
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59054698
114BCAT_22108803_ChIP-Seq_LS180_Human0.57631822
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.57163554
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.56939661
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.56939661
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55243993
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52833117
120* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.51531096
121CJUN_26792858_Chip-Seq_BT549_Human0.51397429
122SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.51183965
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.50827514
124* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50652118
125RARA_24833708_ChIP-Seq_LIVER_Mouse0.50452734
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.50231200
127SOX9_24532713_ChIP-Seq_HFSC_Mouse0.49905388
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.49056647
129STAT1_17558387_ChIP-Seq_HELA_Human0.47741964
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.46536433
131PU_27001747_Chip-Seq_BMDM_Mouse0.45903870
132MYB_21317192_ChIP-Seq_ERMYB_Mouse0.45685009
133CEBPB_22108803_ChIP-Seq_LS180_Human0.44542451
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.44195024
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.43274428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.00169163
2MP0005360_urolithiasis6.52950084
3MP0005085_abnormal_gallbladder_physiolo6.01210490
4MP0005365_abnormal_bile_salt5.39461157
5MP0008875_abnormal_xenobiotic_pharmacok4.44544976
6MP0003191_abnormal_cellular_cholesterol4.11955526
7MP0003252_abnormal_bile_duct4.09465459
8MP0009840_abnormal_foam_cell3.59466594
9MP0010329_abnormal_lipoprotein_level3.34143909
10MP0003806_abnormal_nucleotide_metabolis3.05613043
11MP0005332_abnormal_amino_acid2.33666902
12MP0005083_abnormal_biliary_tract2.26243777
13MP0001666_abnormal_nutrient_absorption2.20987394
14MP0000609_abnormal_liver_physiology2.16669567
15MP0002118_abnormal_lipid_homeostasis2.05809917
16MP0004019_abnormal_vitamin_homeostasis1.98177812
17MP0003195_calcinosis1.97666401
18MP0005670_abnormal_white_adipose1.96250524
19MP0003329_amyloid_beta_deposits1.91864430
20MP0009785_altered_susceptibility_to1.91440276
21MP0002148_abnormal_hypersensitivity_rea1.81868698
22MP0006082_CNS_inflammation1.80234640
23MP0005387_immune_system_phenotype1.78852829
24MP0001790_abnormal_immune_system1.78852829
25MP0002138_abnormal_hepatobiliary_system1.72933022
26MP0002998_abnormal_bone_remodeling1.70473691
27MP0000685_abnormal_immune_system1.67268184
28MP0005319_abnormal_enzyme/_coenzyme1.62709390
29MP0005058_abnormal_lysosome_morphology1.61664086
30MP0003690_abnormal_glial_cell1.61607025
31MP0005584_abnormal_enzyme/coenzyme_acti1.51363064
32MP0003868_abnormal_feces_composition1.49247604
33MP0002254_reproductive_system_inflammat1.47775255
34MP0010368_abnormal_lymphatic_system1.42726144
35MP0000920_abnormal_myelination1.41605862
36MP0001764_abnormal_homeostasis1.37246755
37MP0005000_abnormal_immune_tolerance1.35086877
38MP0005464_abnormal_platelet_physiology1.34333355
39MP0009278_abnormal_bone_marrow1.32740136
40MP0003724_increased_susceptibility_to1.30130497
41MP0005397_hematopoietic_system_phenotyp1.27105607
42MP0001545_abnormal_hematopoietic_system1.27105607
43MP0003879_abnormal_hair_cell1.26881735
44MP0002452_abnormal_antigen_presenting1.24179250
45MP0005647_abnormal_sex_gland1.22691735
46MP0009643_abnormal_urine_homeostasis1.21346619
47MP0008469_abnormal_protein_level1.20157604
48MP0003705_abnormal_hypodermis_morpholog1.19423306
49MP0004130_abnormal_muscle_cell1.18851030
50MP0002723_abnormal_immune_serum1.15709535
51MP0000598_abnormal_liver_morphology1.15557157
52MP0003075_altered_response_to1.14616759
53MP0009697_abnormal_copulation1.13251035
54MP0005451_abnormal_body_composition1.12982769
55MP0009763_increased_sensitivity_to1.08793149
56MP0005167_abnormal_blood-brain_barrier1.08137401
57MP0005666_abnormal_adipose_tissue1.07827752
58MP0003828_pulmonary_edema1.07384780
59MP0001800_abnormal_humoral_immune1.05041450
60MP0009764_decreased_sensitivity_to1.04941300
61MP0010155_abnormal_intestine_physiology1.03399370
62MP0003172_abnormal_lysosome_physiology1.03065647
63MP0003183_abnormal_peptide_metabolism1.01759040
64MP0000604_amyloidosis1.00627923
65MP0003656_abnormal_erythrocyte_physiolo1.00352023
66MP0002928_abnormal_bile_duct0.97787724
67MP0002971_abnormal_brown_adipose0.93396070
68MP0003011_delayed_dark_adaptation0.92314160
69MP0005310_abnormal_salivary_gland0.91684517
70MP0004510_myositis0.91679461
71MP0009642_abnormal_blood_homeostasis0.90286819
72MP0005334_abnormal_fat_pad0.88888135
73MP0001819_abnormal_immune_cell0.87788206
74MP0002420_abnormal_adaptive_immunity0.86155637
75MP0003300_gastrointestinal_ulcer0.86148598
76MP0004947_skin_inflammation0.85373183
77MP0003186_abnormal_redox_activity0.84296499
78MP0003634_abnormal_glial_cell0.84136369
79MP0005535_abnormal_body_temperature0.83501924
80MP0002405_respiratory_system_inflammati0.82832789
81MP0003436_decreased_susceptibility_to0.82738552
82MP0005166_decreased_susceptibility_to0.82673541
83MP0003303_peritoneal_inflammation0.81361864
84MP0003448_altered_tumor_morphology0.79852886
85MP0002419_abnormal_innate_immunity0.79307761
86MP0000858_altered_metastatic_potential0.79221981
87MP0004185_abnormal_adipocyte_glucose0.79194055
88MP0003632_abnormal_nervous_system0.78748149
89MP0004883_abnormal_blood_vessel0.77519936
90MP0000249_abnormal_blood_vessel0.74958354
91MP0003453_abnormal_keratinocyte_physiol0.74915228
92MP0009333_abnormal_splenocyte_physiolog0.73259133
93MP0003279_aneurysm0.72883792
94MP0001835_abnormal_antigen_presentation0.72870223
95MP0002090_abnormal_vision0.72342871
96MP0008874_decreased_physiological_sensi0.71240975
97MP0001756_abnormal_urination0.70771910
98MP0002078_abnormal_glucose_homeostasis0.69462865
99MP0005376_homeostasis/metabolism_phenot0.69332033
100MP0008260_abnormal_autophagy0.69319931
101MP0008873_increased_physiological_sensi0.68168817
102MP0002896_abnormal_bone_mineralization0.67531511
103MP0009765_abnormal_xenobiotic_induced0.66917123
104MP0003638_abnormal_response/metabolism_0.64418013
105MP0008004_abnormal_stomach_pH0.64358715
106MP0009053_abnormal_anal_canal0.64096426
107MP0001533_abnormal_skeleton_physiology0.63837339
108MP0001853_heart_inflammation0.62631513
109MP0001986_abnormal_taste_sensitivity0.61450210
110MP0001845_abnormal_inflammatory_respons0.60979234
111MP0009115_abnormal_fat_cell0.60972803
112MP0005636_abnormal_mineral_homeostasis0.60940231
113MP0002136_abnormal_kidney_physiology0.60760802
114MP0009384_cardiac_valve_regurgitation0.58836747
115MP0005671_abnormal_response_to0.58427174
116MP0005084_abnormal_gallbladder_morpholo0.58244894
117MP0005448_abnormal_energy_balance0.54015764
118MP0000343_altered_response_to0.53820910
119MP0005164_abnormal_response_to0.53568759
120MP0001915_intracranial_hemorrhage0.53425716
121MP0005375_adipose_tissue_phenotype0.52832842
122MP0000639_abnormal_adrenal_gland0.51508268
123MP0004782_abnormal_surfactant_physiolog0.51180766
124MP0002876_abnormal_thyroid_physiology0.50554884
125MP0001851_eye_inflammation0.50143828
126MP0005165_increased_susceptibility_to0.47332469
127MP0005408_hypopigmentation0.46562370
128MP0005025_abnormal_response_to0.46474879
129MP0000230_abnormal_systemic_arterial0.45302693
130MP0005595_abnormal_vascular_smooth0.41930742
131MP0005023_abnormal_wound_healing0.41928783
132MP0003633_abnormal_nervous_system0.40994512
133MP0000767_abnormal_smooth_muscle0.40248367
134MP0005220_abnormal_exocrine_pancreas0.38921903
135MP0002168_other_aberrant_phenotype0.38330131

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)7.58440146
2Systemic lupus erythematosus (HP:0002725)6.50312970
3Deep venous thrombosis (HP:0002625)6.46102009
4Intrahepatic cholestasis (HP:0001406)6.12302151
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.08545420
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.70815524
7Prolonged partial thromboplastin time (HP:0003645)5.69120033
8Abnormality of complement system (HP:0005339)5.55814031
9Glomerulonephritis (HP:0000099)5.53929065
10Xanthomatosis (HP:0000991)5.48073909
11Hypobetalipoproteinemia (HP:0003563)5.08271733
12Hyperlipoproteinemia (HP:0010980)4.86679434
13Vacuolated lymphocytes (HP:0001922)4.85130416
14Joint hemorrhage (HP:0005261)4.51521013
15Increased cerebral lipofuscin (HP:0011813)4.42586776
16Hypolipoproteinemia (HP:0010981)4.14431782
17Mutism (HP:0002300)4.01433056
18Hyperammonemia (HP:0001987)3.99954922
19Hypoalphalipoproteinemia (HP:0003233)3.97903859
20Epidermoid cyst (HP:0200040)3.90205980
21Abnormality of the common coagulation pathway (HP:0010990)3.85076275
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.84007363
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.69821295
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.66894927
25Ketosis (HP:0001946)3.65801853
26Hyperglycinemia (HP:0002154)3.61971376
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.54406208
28Neurofibrillary tangles (HP:0002185)3.47405606
29Abnormality of methionine metabolism (HP:0010901)3.46112285
30Hyperglycinuria (HP:0003108)3.43781308
31Myocardial infarction (HP:0001658)3.42348679
32Disinhibition (HP:0000734)3.40906121
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.40332883
34Abnormality of macrophages (HP:0004311)3.39317020
35Hypoglycemic coma (HP:0001325)3.39260792
36Fat malabsorption (HP:0002630)3.37318465
37Abnormality of the intrinsic pathway (HP:0010989)3.32546062
38Abnormality of glycine metabolism (HP:0010895)3.32123303
39Abnormality of serine family amino acid metabolism (HP:0010894)3.32123303
40Nephritis (HP:0000123)3.27623489
41Abnormality of polysaccharide metabolism (HP:0011012)3.26958932
42Abnormality of glycosaminoglycan metabolism (HP:0004371)3.26958932
43Abnormality of mucopolysaccharide metabolism (HP:0011020)3.26958932
44Hypercholesterolemia (HP:0003124)3.24254466
45Urinary glycosaminoglycan excretion (HP:0003541)3.20573644
46Mucopolysacchariduria (HP:0008155)3.20573644
47Abnormality of pyrimidine metabolism (HP:0004353)3.12016842
48Eczematoid dermatitis (HP:0000976)3.09589044
49Loss of speech (HP:0002371)3.08991278
50Conjugated hyperbilirubinemia (HP:0002908)3.04492501
51Purpura (HP:0000979)2.99802502
52Amyloidosis (HP:0011034)2.95719412
53Abnormality of fatty-acid metabolism (HP:0004359)2.93093566
54Recurrent abscess formation (HP:0002722)2.82888229
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.80227425
56Recurrent gram-negative bacterial infections (HP:0005420)2.79943295
57Retinal atrophy (HP:0001105)2.74687426
58Spontaneous hematomas (HP:0007420)2.71056637
59Recurrent bacterial skin infections (HP:0005406)2.67387774
60Hyperbilirubinemia (HP:0002904)2.61060264
61Ketoacidosis (HP:0001993)2.60051877
62Skin nodule (HP:0200036)2.58830975
63Abnormality of nucleobase metabolism (HP:0010932)2.57572728
64Axonal loss (HP:0003447)2.56143442
65Hepatocellular carcinoma (HP:0001402)2.54955239
66Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52362191
67Delayed CNS myelination (HP:0002188)2.51909104
68Abnormality of the vasculature of the conjunctiva (HP:0008054)2.49245870
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.47558688
70Steatorrhea (HP:0002570)2.46191065
71Cerebral inclusion bodies (HP:0100314)2.44203152
72Abnormality of serum amino acid levels (HP:0003112)2.42750202
73Upper motor neuron abnormality (HP:0002127)2.40241182
74Sensorimotor neuropathy (HP:0007141)2.37038530
75Vascular calcification (HP:0004934)2.36106503
76Neuronal loss in central nervous system (HP:0002529)2.35372330
77Mitral stenosis (HP:0001718)2.34222704
78Hemorrhage of the eye (HP:0011885)2.33971922
79Abnormality of purine metabolism (HP:0004352)2.30350670
80Esophageal varix (HP:0002040)2.29900049
81Spontaneous abortion (HP:0005268)2.26304452
82Hypochromic microcytic anemia (HP:0004840)2.23928102
83Abnormality of the periventricular white matter (HP:0002518)2.22000986
84Metabolic acidosis (HP:0001942)2.21753457
85Mediastinal lymphadenopathy (HP:0100721)2.21637093
86Hypoglycemic seizures (HP:0002173)2.20579934
87Increased serum ferritin (HP:0003281)2.19728241
88Pathologic fracture (HP:0002756)2.18259906
89Gingivitis (HP:0000230)2.16032519
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14121387
91Dicarboxylic aciduria (HP:0003215)2.14121387
92Abnormality of glycolipid metabolism (HP:0010969)2.12929210
93Abnormality of liposaccharide metabolism (HP:0010968)2.12929210
94Abnormality of glycosphingolipid metabolism (HP:0004343)2.12929210
95Gingival bleeding (HP:0000225)2.12018415
96Peripheral demyelination (HP:0011096)2.11846480
97Agnosia (HP:0010524)2.10688918
98Cardiovascular calcification (HP:0011915)2.10113417
99Menorrhagia (HP:0000132)2.09562579
100Dementia (HP:0000726)2.06382525
101Malnutrition (HP:0004395)2.00128330
102Spastic diplegia (HP:0001264)1.98534426
103Irritability (HP:0000737)1.97998849
104Nuclear cataract (HP:0100018)1.96418098
105J-shaped sella turcica (HP:0002680)1.96403393
106Abnormal gallbladder morphology (HP:0012437)1.95173531
107Abnormality of proline metabolism (HP:0010907)1.94352922
108Hydroxyprolinuria (HP:0003080)1.94352922
109Thrombophlebitis (HP:0004418)1.93266638
110Cholelithiasis (HP:0001081)1.92955962
111Bone pain (HP:0002653)1.91574568
112Autoimmune thrombocytopenia (HP:0001973)1.91310048
113Lethargy (HP:0001254)1.91085836
114Progressive visual loss (HP:0000529)1.89631112
115Neonatal onset (HP:0003623)1.88963345
116Pancreatitis (HP:0001733)1.88139338
117Polycythemia (HP:0001901)1.87406623
118Asymmetric septal hypertrophy (HP:0001670)1.86700079
119Status epilepticus (HP:0002133)1.86330642
120Cerebral aneurysm (HP:0004944)1.86309871
121Dysostosis multiplex (HP:0000943)1.86235236
122Stroke (HP:0001297)1.86014599
123Abnormal gallbladder physiology (HP:0012438)1.85457439
124Cholecystitis (HP:0001082)1.85457439
125Recurrent skin infections (HP:0001581)1.85434023
126Hyperinsulinemic hypoglycemia (HP:0000825)1.84407004
127Apathy (HP:0000741)1.84153847
128Thoracic kyphosis (HP:0002942)1.83205810
129Gout (HP:0001997)1.82907127
130Conjunctival telangiectasia (HP:0000524)1.82771419
131Colitis (HP:0002583)1.82766317
132Acanthocytosis (HP:0001927)1.82490989
133Protuberant abdomen (HP:0001538)1.80752605
134Arterial tortuosity (HP:0005116)1.80459260
135Diminished motivation (HP:0000745)1.80335386
136Epistaxis (HP:0000421)1.80121147
137Abnormality of iron homeostasis (HP:0011031)1.79573468
138Abnormality of transition element cation homeostasis (HP:0011030)1.78887436
139Pulmonary embolism (HP:0002204)1.77563792
140Inappropriate behavior (HP:0000719)1.77459961
141Cardiomegaly (HP:0001640)1.77187386
142Increased CSF protein (HP:0002922)1.77027832
143Abnormal platelet function (HP:0011869)1.76841720
144Impaired platelet aggregation (HP:0003540)1.76841720
145Abnormality of the Achilles tendon (HP:0005109)1.76827725
146Interstitial pulmonary disease (HP:0006530)1.76634589
147Metaphyseal irregularity (HP:0003025)1.75680752
148Late onset (HP:0003584)1.75601429
149Hematochezia (HP:0002573)1.75260719
150Disproportionate tall stature (HP:0001519)1.75072621
151Hypophosphatemia (HP:0002148)1.73966401
152Orchitis (HP:0100796)1.73116274
153Personality changes (HP:0000751)1.68338375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.54515227
2MAPK154.14864336
3BCKDK3.59485385
4ERN13.40307933
5SIK12.77163361
6CSF1R2.60461937
7FGFR42.57765746
8GRK72.53524661
9TYK22.48285235
10CAMK1D2.43869061
11INSRR2.29579888
12ACVR1B2.27018172
13DDR21.92273401
14TIE11.82429935
15CAMK1G1.81604714
16CDC42BPA1.80918963
17PKN21.72149708
18PRPF4B1.63837866
19JAK11.58855000
20MAPK121.55090281
21NEK91.53684675
22TAOK31.53435375
23FGR1.47877576
24PIK3CG1.47139365
25IRAK31.42699594
26TBK11.42486720
27PDK21.41622172
28MAP2K31.37934363
29KDR1.36213285
30TRIB31.34533092
31MAP3K111.33714969
32JAK21.30982080
33PTK61.28986385
34JAK31.26031917
35PRKAA21.25776994
36BLK1.24190712
37MAP2K41.22216880
38EPHA31.17760578
39EPHB11.15195743
40CSK1.12172626
41MAPK111.12059832
42MAPK71.08097227
43MAP3K11.05306922
44MST1R1.01564355
45SYK0.97272797
46PAK40.94660834
47FLT30.93986137
48PRKG20.91376332
49TSSK60.89995586
50MAP3K30.89905949
51PDGFRA0.89728415
52ERBB40.89571229
53MAP3K100.88488307
54NME20.86921058
55CDK60.84742244
56MAP3K70.83696130
57FGFR20.81655971
58MAP3K140.79552590
59CAMK40.78706234
60EPHB20.77984777
61GSK3A0.77697980
62MAPK40.77633975
63MAP4K10.77148042
64FRK0.76234478
65IGF1R0.74941025
66ITK0.74040973
67ZAP700.73526098
68PDPK10.73396676
69PDK10.70803356
70RIPK10.69423383
71STK100.67701721
72TNK20.66332839
73MAP3K20.65762188
74PAK20.65469614
75MOS0.63499412
76TAOK20.63067617
77DAPK20.63048125
78ICK0.63029253
79HCK0.62030545
80LATS10.61989374
81TAOK10.61795087
82MATK0.61748035
83RPS6KA20.60640812
84KSR20.58295940
85PRKCZ0.55785249
86MARK20.54332738
87GRK10.53993979
88MAP3K60.53031677
89TESK20.52417089
90PDGFRB0.52355265
91CAMKK10.52028878
92MAP2K20.51638913
93SGK30.50936248
94PKN10.50725863
95GRK50.49349745
96TGFBR10.48802500
97LYN0.48576448
98TYRO30.48496081
99PRKAA10.48386489
100ERBB20.47650732
101NTRK30.47170567
102PINK10.46690498
103FGFR30.46296709
104MAP2K60.44699515
105IKBKE0.44639614
106PRKACG0.44243657
107EGFR0.44046833
108RET0.43841905
109FYN0.43660288
110ABL20.43567787
111IKBKB0.43513812
112MAPKAPK30.43201191
113TESK10.42872274
114IRAK40.42443194
115SRC0.41468461
116RIPK40.40659666
117PRKD10.40621524
118ABL10.39673167
119PIM20.39122790
120FER0.38607410
121FES0.38571038
122KIT0.38159699
123PRKG10.37383508
124RPS6KL10.37201131
125RPS6KC10.37201131
126MAP3K130.36078302
127ADRBK20.35908112
128INSR0.34345129
129EEF2K0.33556767
130CDK30.33253265
131STK110.31397107
132LCK0.30700955
133SIK20.30575208
134CAMKK20.29423207
135PTK2B0.28928907
136IRAK20.28439241

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.34385588
2Nitrogen metabolism_Homo sapiens_hsa009103.97085401
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21240883
4Complement and coagulation cascades_Homo sapiens_hsa046103.13216494
5Staphylococcus aureus infection_Homo sapiens_hsa051503.09174314
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.00586242
7Arginine biosynthesis_Homo sapiens_hsa002202.97488426
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56722828
9Tryptophan metabolism_Homo sapiens_hsa003802.52795667
10Fatty acid degradation_Homo sapiens_hsa000712.41702644
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33162584
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26729030
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24012376
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14598729
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08951902
16PPAR signaling pathway_Homo sapiens_hsa033202.02211665
17Butanoate metabolism_Homo sapiens_hsa006501.91526384
18Peroxisome_Homo sapiens_hsa041461.90818315
19Propanoate metabolism_Homo sapiens_hsa006401.86219683
20Chemical carcinogenesis_Homo sapiens_hsa052041.85299843
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83205762
22Caffeine metabolism_Homo sapiens_hsa002321.81366808
23Fatty acid metabolism_Homo sapiens_hsa012121.78636361
24Histidine metabolism_Homo sapiens_hsa003401.76071195
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.74332772
26beta-Alanine metabolism_Homo sapiens_hsa004101.62337472
27Bile secretion_Homo sapiens_hsa049761.56788974
28Retinol metabolism_Homo sapiens_hsa008301.54928977
29ABC transporters_Homo sapiens_hsa020101.53828630
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.52135912
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49545352
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43988104
33Asthma_Homo sapiens_hsa053101.39576495
34Mineral absorption_Homo sapiens_hsa049781.37795497
35Rheumatoid arthritis_Homo sapiens_hsa053231.35209275
36Phenylalanine metabolism_Homo sapiens_hsa003601.34864946
37Phagosome_Homo sapiens_hsa041451.31139806
38Tuberculosis_Homo sapiens_hsa051521.28180317
39Starch and sucrose metabolism_Homo sapiens_hsa005001.26468912
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25248341
41Tyrosine metabolism_Homo sapiens_hsa003501.22944603
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22099431
43Selenocompound metabolism_Homo sapiens_hsa004501.22035804
44Fat digestion and absorption_Homo sapiens_hsa049751.15015218
45Fatty acid elongation_Homo sapiens_hsa000621.14054032
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11779502
47Allograft rejection_Homo sapiens_hsa053301.10616638
48Pyruvate metabolism_Homo sapiens_hsa006201.09792654
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.06886714
50Sulfur metabolism_Homo sapiens_hsa009201.04905839
51Prion diseases_Homo sapiens_hsa050200.98904827
52Graft-versus-host disease_Homo sapiens_hsa053320.96832283
53Autoimmune thyroid disease_Homo sapiens_hsa053200.96394802
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.95663188
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95614260
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91016652
57Antigen processing and presentation_Homo sapiens_hsa046120.88900661
58Renin-angiotensin system_Homo sapiens_hsa046140.87431991
59Vitamin digestion and absorption_Homo sapiens_hsa049770.86366107
60Folate biosynthesis_Homo sapiens_hsa007900.85317589
61Lysine degradation_Homo sapiens_hsa003100.85189763
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.85009429
63Carbon metabolism_Homo sapiens_hsa012000.83737569
64Biosynthesis of amino acids_Homo sapiens_hsa012300.83453893
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81404380
66Arginine and proline metabolism_Homo sapiens_hsa003300.77438593
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76674000
68Other glycan degradation_Homo sapiens_hsa005110.76388098
69Steroid biosynthesis_Homo sapiens_hsa001000.75414957
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.73803113
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72517097
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.72415246
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70633967
74Glycerolipid metabolism_Homo sapiens_hsa005610.70472294
75Malaria_Homo sapiens_hsa051440.69147204
76Toxoplasmosis_Homo sapiens_hsa051450.68871520
77Vitamin B6 metabolism_Homo sapiens_hsa007500.68726267
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67350348
79Sphingolipid metabolism_Homo sapiens_hsa006000.66869979
80Type I diabetes mellitus_Homo sapiens_hsa049400.66147230
81Hematopoietic cell lineage_Homo sapiens_hsa046400.65029029
82Fatty acid biosynthesis_Homo sapiens_hsa000610.58364288
83Collecting duct acid secretion_Homo sapiens_hsa049660.55579526
84Sulfur relay system_Homo sapiens_hsa041220.55168516
85Amoebiasis_Homo sapiens_hsa051460.52763333
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52035948
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.47389484
88Lysosome_Homo sapiens_hsa041420.44968037
89Salmonella infection_Homo sapiens_hsa051320.44377839
90TNF signaling pathway_Homo sapiens_hsa046680.44258526
91Glutathione metabolism_Homo sapiens_hsa004800.43774275
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42565764
93Chemokine signaling pathway_Homo sapiens_hsa040620.40777906
94Insulin resistance_Homo sapiens_hsa049310.39015450
95Influenza A_Homo sapiens_hsa051640.38293064
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.34222810
97Viral myocarditis_Homo sapiens_hsa054160.33894716
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.33130599
99Systemic lupus erythematosus_Homo sapiens_hsa053220.32823853
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32192110
101Pertussis_Homo sapiens_hsa051330.31645064
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31531661
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30642146
104Platelet activation_Homo sapiens_hsa046110.30588007
105Metabolic pathways_Homo sapiens_hsa011000.27992264
106Pentose phosphate pathway_Homo sapiens_hsa000300.27456361
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27249989
108Vibrio cholerae infection_Homo sapiens_hsa051100.26087643
109Renin secretion_Homo sapiens_hsa049240.24838583
110Osteoclast differentiation_Homo sapiens_hsa043800.24229315
111One carbon pool by folate_Homo sapiens_hsa006700.21685554
112Fructose and mannose metabolism_Homo sapiens_hsa000510.17548179
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17152750
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15073190
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13047253
116Galactose metabolism_Homo sapiens_hsa000520.12064547
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09308187
118Glucagon signaling pathway_Homo sapiens_hsa049220.08287318
119African trypanosomiasis_Homo sapiens_hsa051430.06110939
120AMPK signaling pathway_Homo sapiens_hsa041520.04999815
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.03641946
122B cell receptor signaling pathway_Homo sapiens_hsa046620.01895999
123Linoleic acid metabolism_Homo sapiens_hsa005910.01584162
124Ether lipid metabolism_Homo sapiens_hsa005650.01323182
125Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0902551
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0725538
127Leishmaniasis_Homo sapiens_hsa05140-0.0650030
128Legionellosis_Homo sapiens_hsa05134-0.0630787
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0508755
130Insulin signaling pathway_Homo sapiens_hsa04910-0.0373027
131Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0147271
132Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0041322
133Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0017924

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