SLCO3A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.14951724
2central nervous system myelination (GO:0022010)7.14951724
3fatty acid elongation (GO:0030497)4.88214641
4desmosome organization (GO:0002934)4.74810192
5long-chain fatty acid biosynthetic process (GO:0042759)4.68522516
6macrophage activation involved in immune response (GO:0002281)4.57087289
7negative regulation of cell killing (GO:0031342)4.55419799
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.55419799
9positive regulation by symbiont of host defense response (GO:0052509)4.52203495
10modulation by symbiont of host defense response (GO:0052031)4.52203495
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.52203495
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.52203495
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.52203495
14modulation by symbiont of host immune response (GO:0052553)4.52203495
15negative regulation of interleukin-12 production (GO:0032695)4.52018722
16response to peptidoglycan (GO:0032494)4.50591971
17positive regulation of gamma-delta T cell activation (GO:0046645)4.46295045
18creatine metabolic process (GO:0006600)4.28196080
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13947710
20negative regulation of protein localization to cell surface (GO:2000009)4.05310067
21myelin maintenance (GO:0043217)4.03356370
22detection of other organism (GO:0098543)3.93372550
23regulation of interferon-beta biosynthetic process (GO:0045357)3.74983930
24detection of molecule of bacterial origin (GO:0032490)3.70988258
25detection of bacterium (GO:0016045)3.62952246
26cellular response to type I interferon (GO:0071357)3.54877690
27type I interferon signaling pathway (GO:0060337)3.54877690
28response to type I interferon (GO:0034340)3.54337328
29leukocyte aggregation (GO:0070486)3.53512044
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.50517853
31microglial cell activation (GO:0001774)3.46350824
32neutrophil activation (GO:0042119)3.46159141
33axon ensheathment (GO:0008366)3.44457391
34ensheathment of neurons (GO:0007272)3.44457391
35negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.43671284
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.43456720
37detection of external biotic stimulus (GO:0098581)3.43434311
38granulocyte activation (GO:0036230)3.42772506
39myelination (GO:0042552)3.36460060
40antigen processing and presentation of endogenous antigen (GO:0019883)3.33684829
41macrophage activation (GO:0042116)3.30744830
42immunoglobulin mediated immune response (GO:0016064)3.30197485
43myeloid cell activation involved in immune response (GO:0002275)3.28416156
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.28003860
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.26696458
46amyloid precursor protein metabolic process (GO:0042982)3.26432345
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26049168
48negative regulation of T cell mediated immunity (GO:0002710)3.25328020
49germinal center formation (GO:0002467)3.23213842
50cellular extravasation (GO:0045123)3.22771999
51membrane tubulation (GO:0097320)3.21692913
52regulation of gamma-delta T cell activation (GO:0046643)3.21137684
53sarcomere organization (GO:0045214)3.20746893
54regulation of interferon-alpha production (GO:0032647)3.20517684
55regulation of B cell receptor signaling pathway (GO:0050855)3.19333667
56positive regulation of mast cell activation (GO:0033005)3.16662030
57defense response to protozoan (GO:0042832)3.16105192
58protein localization to endosome (GO:0036010)3.15339629
59positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.11933269
60interferon-gamma-mediated signaling pathway (GO:0060333)3.07743124
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.07493055
62regulation of T-helper 2 cell differentiation (GO:0045628)3.07383811
63negative regulation of cytokine production involved in immune response (GO:0002719)3.06941820
64detection of biotic stimulus (GO:0009595)3.06351583
65response to host immune response (GO:0052572)3.05014658
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.05014658
67positive regulation of type 2 immune response (GO:0002830)3.04007666
68regulation of T cell tolerance induction (GO:0002664)3.03726349
69regulation of mast cell degranulation (GO:0043304)3.02086716
70response to muramyl dipeptide (GO:0032495)3.01323822
71response to protozoan (GO:0001562)3.00012672
72neuron remodeling (GO:0016322)2.99868786
73regulation of mast cell activation (GO:0033003)2.99734312
74regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98580362
75negative regulation of leukocyte mediated immunity (GO:0002704)2.97433434
76positive regulation of toll-like receptor signaling pathway (GO:0034123)2.96541178
77positive regulation of interferon-alpha production (GO:0032727)2.94216703
78regulation of tolerance induction (GO:0002643)2.93764728
79sphingosine metabolic process (GO:0006670)2.91581976
80photoreceptor cell differentiation (GO:0046530)2.89969468
81eye photoreceptor cell differentiation (GO:0001754)2.89969468
82sphingoid metabolic process (GO:0046519)2.89123876
83positive regulation of mast cell activation involved in immune response (GO:0033008)2.87591876
84positive regulation of mast cell degranulation (GO:0043306)2.87591876
85positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.87000045
86neutrophil mediated immunity (GO:0002446)2.86452511
87membrane raft organization (GO:0031579)2.85048379
88regulation of mast cell activation involved in immune response (GO:0033006)2.84697264
89tolerance induction (GO:0002507)2.81289539
90negative regulation of interleukin-6 production (GO:0032715)2.78827445
91phosphatidylinositol acyl-chain remodeling (GO:0036149)2.78479974
92regulation of type 2 immune response (GO:0002828)2.77814650
93regulation of lipoprotein metabolic process (GO:0050746)2.77594188
94regulation of collateral sprouting (GO:0048670)2.77524322
95negative regulation of neurotransmitter transport (GO:0051589)2.75775970
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73640351
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.73025649
98response to host (GO:0075136)2.73025649
99response to host defenses (GO:0052200)2.73025649
100establishment of mitochondrion localization (GO:0051654)2.72748418
101positive regulation of antigen processing and presentation (GO:0002579)2.72563421
102positive regulation of interleukin-1 beta secretion (GO:0050718)2.72187078
103leukocyte degranulation (GO:0043299)2.71802874
104negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.71733448
105positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.70825327
106negative regulation of potassium ion transmembrane transport (GO:1901380)2.70401174
107myofibril assembly (GO:0030239)2.69671496
108regulation of actin filament-based movement (GO:1903115)2.69312057
109production of molecular mediator involved in inflammatory response (GO:0002532)2.67565577
110positive regulation of tolerance induction (GO:0002645)2.66878710
111regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66507548
112regulation of relaxation of muscle (GO:1901077)2.66402327
113leukocyte migration involved in inflammatory response (GO:0002523)2.64645710
114positive regulation of NF-kappaB import into nucleus (GO:0042346)2.64341754
115regulation of antigen processing and presentation (GO:0002577)2.64036090
116regulation of interleukin-12 production (GO:0032655)2.61797801
117regulation of interleukin-8 biosynthetic process (GO:0045414)2.61774695
118interferon-gamma secretion (GO:0072643)2.60796291
119negative regulation of type 2 immune response (GO:0002829)2.60169722
120positive regulation of interleukin-1 secretion (GO:0050716)2.59841233
121negative regulation of production of molecular mediator of immune response (GO:0002701)2.59754594
122diol metabolic process (GO:0034311)2.59404890
123regulation of regulatory T cell differentiation (GO:0045589)2.59236103
124respiratory burst (GO:0045730)2.58285235
125cardiac myofibril assembly (GO:0055003)2.57737481
126positive regulation of interferon-beta production (GO:0032728)2.57463282
127regulation of leukocyte degranulation (GO:0043300)2.56615264
128regulation of T-helper 1 cell differentiation (GO:0045625)2.56309424
129sarcoplasmic reticulum calcium ion transport (GO:0070296)2.55840958
130negative regulation of alpha-beta T cell activation (GO:0046636)2.53907614
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53573520
132response to methylmercury (GO:0051597)2.52523584
133regulation of toll-like receptor signaling pathway (GO:0034121)2.52361949
134response to interleukin-15 (GO:0070672)2.52135582
135negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.50072795
136long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.48249620
137extracellular matrix assembly (GO:0085029)2.47969828
138bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47839114
139regulation of cell proliferation involved in kidney development (GO:1901722)2.46048282
140positive regulation of interleukin-17 production (GO:0032740)2.41312960
141potassium ion import (GO:0010107)2.41091952
142cellular response to interferon-alpha (GO:0035457)2.40775698
143regulation of cytokine production involved in inflammatory response (GO:1900015)2.39421499
144phosphatidylserine acyl-chain remodeling (GO:0036150)2.38676398
145positive regulation of natural killer cell differentiation (GO:0032825)2.37305472
146hemidesmosome assembly (GO:0031581)2.33824667
147nerve growth factor signaling pathway (GO:0038180)2.33479874
148T-helper 1 type immune response (GO:0042088)2.32597836
149negative regulation of execution phase of apoptosis (GO:1900118)2.32405369
150positive regulation of interleukin-4 production (GO:0032753)2.31665744
151positive regulation of actin filament depolymerization (GO:0030836)2.31384785
152regulation of cardiac muscle cell contraction (GO:0086004)2.30245448
153magnesium ion transport (GO:0015693)2.27076159
154ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.26621904
155amyloid precursor protein catabolic process (GO:0042987)2.25698692
156regulation of interleukin-13 production (GO:0032656)2.25444158
157cardiac muscle tissue morphogenesis (GO:0055008)2.25334291
158actin-myosin filament sliding (GO:0033275)2.25034462
159muscle filament sliding (GO:0030049)2.25034462
160keratinocyte proliferation (GO:0043616)2.24576621
161adhesion of symbiont to host cell (GO:0044650)2.23896596
162virion attachment to host cell (GO:0019062)2.23896596
163positive regulation of pseudopodium assembly (GO:0031274)2.23462119
164enteric nervous system development (GO:0048484)2.21678857
165tissue regeneration (GO:0042246)2.20054515
166negative regulation of chemokine production (GO:0032682)2.19677034
167atrioventricular valve morphogenesis (GO:0003181)2.19672169
168keratinization (GO:0031424)2.18827922
169oxygen transport (GO:0015671)2.18730067
170fatty-acyl-CoA metabolic process (GO:0035337)2.18036566
171negative regulation of Rho protein signal transduction (GO:0035024)2.16110702
172positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.14677383
173asymmetric protein localization (GO:0008105)2.11889121
174establishment of endothelial barrier (GO:0061028)2.11872606
175neutrophil activation involved in immune response (GO:0002283)2.10691690
176regulation of hypersensitivity (GO:0002883)2.10163026
177regulation of striated muscle contraction (GO:0006942)2.09997606
178regulation of pseudopodium assembly (GO:0031272)2.08696869
179negative regulation of neurotransmitter secretion (GO:0046929)2.07505583
180plasma membrane repair (GO:0001778)2.05795470
181hypotonic response (GO:0006971)2.05613413
182axon development (GO:0061564)2.05252830
183regulation of water loss via skin (GO:0033561)2.04136707
184establishment of skin barrier (GO:0061436)2.03046174
185keratinocyte differentiation (GO:0030216)2.02874433
186phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.02640271
187regulation of natural killer cell differentiation (GO:0032823)2.02488732
188regulation of glomerular filtration (GO:0003093)2.00944652
189positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.00824351
190positive regulation of T cell cytokine production (GO:0002726)2.00523366
191peptidyl-tyrosine autophosphorylation (GO:0038083)1.99519908
192mast cell activation (GO:0045576)1.99237640
193regulation of cardioblast differentiation (GO:0051890)1.97857279
194actin-mediated cell contraction (GO:0070252)1.97541081
195metanephric nephron epithelium development (GO:0072243)1.97340777
196endothelial cell development (GO:0001885)1.96782406

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.94397955
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.38424583
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.02517450
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39980921
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09430109
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02891752
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02447255
8CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96597453
9MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92165030
10* EP300_21415370_ChIP-Seq_HL-1_Mouse1.85786479
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.84871718
12SPI1_23127762_ChIP-Seq_K562_Human1.84846672
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81866605
14AR_21572438_ChIP-Seq_LNCaP_Human1.76157680
15SCL_19346495_ChIP-Seq_HPC-7_Human1.74307974
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70521535
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.70374897
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68379220
19VDR_24763502_ChIP-Seq_THP-1_Human1.66950169
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66487621
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64286580
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60730208
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59932107
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59260696
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.57126287
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56278904
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53203389
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.52682114
29* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48915302
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48874499
31* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46895498
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46892160
33* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44285305
34* DROSHA_22980978_ChIP-Seq_HELA_Human1.41738759
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40899831
36* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40872491
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40425503
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37861962
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37566446
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37284094
41CJUN_26792858_Chip-Seq_BT549_Human1.37223131
42* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36890440
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35780646
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33885944
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.32129462
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.30795463
47* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29902955
48* TP63_23658742_ChIP-Seq_EP156T_Human1.29363213
49* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29155561
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28456801
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28232978
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28232978
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27472514
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27217667
55SPI1_23547873_ChIP-Seq_NB4_Human1.26672366
56KDM2B_26808549_Chip-Seq_DND41_Human1.26370084
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25906625
58* GATA1_19941827_ChIP-Seq_MEL_Mouse1.25257007
59* MYB_26560356_Chip-Seq_TH2_Human1.24993897
60VDR_21846776_ChIP-Seq_THP-1_Human1.24968394
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23218070
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22845625
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.22380799
64* TBX20_22328084_ChIP-Seq_HEART_Mouse1.22271489
65* TBX20_22080862_ChIP-Seq_HEART_Mouse1.22271489
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22223635
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22108865
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21209656
69VDR_22108803_ChIP-Seq_LS180_Human1.20652149
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.18817089
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18731680
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18189513
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17752078
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.17705833
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.15383710
76MAF_26560356_Chip-Seq_TH1_Human1.15150117
77GATA3_27048872_Chip-Seq_THYMUS_Human1.14043804
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13527166
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13527166
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.13226516
81EZH2_22144423_ChIP-Seq_EOC_Human1.13108201
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11465602
83* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11251443
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10681913
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10134991
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09449908
87SOX2_20726797_ChIP-Seq_SW620_Human1.09050645
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.08517455
89UTX_26944678_Chip-Seq_JUKART_Human1.07797242
90* GATA3_26560356_Chip-Seq_TH2_Human1.07329284
91* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04938521
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03698594
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02644488
94TCF7_22412390_ChIP-Seq_EML_Mouse1.02632146
95* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02188669
96* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01214413
97* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01082697
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.00870205
99* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99470897
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98737318
101PU_27001747_Chip-Seq_BMDM_Mouse0.97768034
102* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97208931
103TP53_16413492_ChIP-PET_HCT116_Human0.96717321
104RUNX_20019798_ChIP-Seq_JUKART_Human0.96262990
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.95114768
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94548473
107VDR_24787735_ChIP-Seq_THP-1_Human0.94522645
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.94445942
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93455461
110GATA1_19941826_ChIP-Seq_K562_Human0.93412536
111TP53_18474530_ChIP-ChIP_U2OS_Human0.93124348
112SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92228495
113MYB_26560356_Chip-Seq_TH1_Human0.91775461
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91359852
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91056576
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90798260
117AHR_22903824_ChIP-Seq_MCF-7_Human0.90730482
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90319737
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89451279
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88922380
121* KLF5_25053715_ChIP-Seq_YYC3_Human0.88671168
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88653012
123SMRT_27268052_Chip-Seq_Bcells_Human0.88647716
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88627462
125EGR1_19032775_ChIP-ChIP_M12_Human0.88127682
126EED_16625203_ChIP-ChIP_MESCs_Mouse0.87413063
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.86941220
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.86357282
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84770560
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84310189
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84111898
132RXR_22108803_ChIP-Seq_LS180_Human0.83975895
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83579177
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83403462
135MAF_26560356_Chip-Seq_TH2_Human0.83086274
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81496724
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81459214
138KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81325461
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81106070
140PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80949508
141GATA2_19941826_ChIP-Seq_K562_Human0.80331131
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80203110
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.79948898
144GATA1_22025678_ChIP-Seq_K562_Human0.79610058
145GBX2_23144817_ChIP-Seq_PC3_Human0.79576262
146JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79552306
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79215503
148LXR_22292898_ChIP-Seq_THP-1_Human0.78055578
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.77933747
150OCT1_27270436_Chip-Seq_PROSTATE_Human0.77925320
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77547179
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77484356
153* SMAD3_21741376_ChIP-Seq_EPCs_Human0.77019211
154SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.76933670
155SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.76933670
156* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.76930859
157KDM2B_26808549_Chip-Seq_K562_Human0.76761166
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.76494154
159* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76087025
160* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75660374
161SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75572832
162* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75076500
163BCL6_27268052_Chip-Seq_Bcells_Human0.74369697
164JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71272366
165PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70363380
166REST_21632747_ChIP-Seq_MESCs_Mouse0.70029867
167STAT1_20625510_ChIP-Seq_HELA_Human0.69519584
168BCOR_27268052_Chip-Seq_Bcells_Human0.69278268
169DNAJC2_21179169_ChIP-ChIP_NT2_Human0.68339293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.23178428
2MP0000920_abnormal_myelination3.22809845
3MP0002796_impaired_skin_barrier3.14788336
4MP0003646_muscle_fatigue3.12603306
5MP0003950_abnormal_plasma_membrane3.03306122
6MP0005451_abnormal_body_composition2.69994371
7MP0001800_abnormal_humoral_immune2.43565215
8MP0004084_abnormal_cardiac_muscle2.41228903
9MP0004381_abnormal_hair_follicle2.34574094
10MP0010678_abnormal_skin_adnexa2.33547752
11MP0002723_abnormal_immune_serum2.30987836
12MP0004036_abnormal_muscle_relaxation2.30855518
13MP0000751_myopathy2.30667248
14MP0000383_abnormal_hair_follicle2.30239960
15MP0003724_increased_susceptibility_to2.26624848
16MP0002837_dystrophic_cardiac_calcinosis2.23663564
17MP0002452_abnormal_antigen_presenting2.22582950
18MP0004510_myositis2.22022456
19MP0009764_decreased_sensitivity_to2.16010558
20MP0003300_gastrointestinal_ulcer2.13138690
21MP0004043_abnormal_pH_regulation2.12769408
22MP0000749_muscle_degeneration2.06065665
23MP0002420_abnormal_adaptive_immunity2.05491989
24MP0001819_abnormal_immune_cell2.04316211
25MP0003329_amyloid_beta_deposits2.01726512
26MP0008775_abnormal_heart_ventricle1.95876012
27MP0005275_abnormal_skin_tensile1.88989643
28MP0005330_cardiomyopathy1.85844482
29MP0005409_darkened_coat_color1.85172570
30MP0001851_eye_inflammation1.84155105
31MP0003172_abnormal_lysosome_physiology1.82230364
32MP0002972_abnormal_cardiac_muscle1.80576549
33MP0004215_abnormal_myocardial_fiber1.79522583
34MP0003453_abnormal_keratinocyte_physiol1.77926052
35MP0004484_altered_response_of1.73344473
36MP0002405_respiratory_system_inflammati1.70021414
37MP0005501_abnormal_skin_physiology1.66662609
38MP0001845_abnormal_inflammatory_respons1.66255371
39MP0009278_abnormal_bone_marrow1.65094101
40MP0000579_abnormal_nail_morphology1.64161093
41MP0005058_abnormal_lysosome_morphology1.58494305
42MP0002148_abnormal_hypersensitivity_rea1.57137323
43MP0001958_emphysema1.56244524
44MP0010155_abnormal_intestine_physiology1.54758296
45MP0003828_pulmonary_edema1.47520016
46MP0005623_abnormal_meninges_morphology1.44307945
47MP0004087_abnormal_muscle_fiber1.43540342
48MP0002106_abnormal_muscle_physiology1.41894571
49MP0000716_abnormal_immune_system1.41716357
50MP0001216_abnormal_epidermal_layer1.41350863
51MP0005620_abnormal_muscle_contractility1.41310049
52MP0003137_abnormal_impulse_conducting1.40906122
53MP0009785_altered_susceptibility_to1.37856301
54MP0005464_abnormal_platelet_physiology1.36108067
55MP0005165_increased_susceptibility_to1.35462764
56MP0008469_abnormal_protein_level1.33281521
57MP0004858_abnormal_nervous_system1.32905151
58MP0004947_skin_inflammation1.32281607
59MP0002277_abnormal_respiratory_mucosa1.31944534
60MP0003763_abnormal_thymus_physiology1.31611163
61MP0003303_peritoneal_inflammation1.31529617
62MP0002998_abnormal_bone_remodeling1.30033303
63MP0001501_abnormal_sleep_pattern1.28008409
64MP0000343_altered_response_to1.27245385
65MP0005310_abnormal_salivary_gland1.26899038
66MP0010771_integument_phenotype1.26389240
67MP0000465_gastrointestinal_hemorrhage1.25440015
68MP0008260_abnormal_autophagy1.25303254
69MP0005166_decreased_susceptibility_to1.23480267
70MP0003880_abnormal_central_pattern1.21273615
71MP0006082_CNS_inflammation1.20988594
72MP0002398_abnormal_bone_marrow1.20659086
73MP0003191_abnormal_cellular_cholesterol1.20104413
74MP0006138_congestive_heart_failure1.19899051
75MP0004185_abnormal_adipocyte_glucose1.18992053
76MP0001765_abnormal_ion_homeostasis1.18668455
77MP0005385_cardiovascular_system_phenoty1.18068155
78MP0001544_abnormal_cardiovascular_syste1.18068155
79MP0003690_abnormal_glial_cell1.16331008
80MP0005369_muscle_phenotype1.16243179
81MP0005387_immune_system_phenotype1.16152803
82MP0001790_abnormal_immune_system1.16152803
83MP0005397_hematopoietic_system_phenotyp1.14952040
84MP0001545_abnormal_hematopoietic_system1.14952040
85MP0005164_abnormal_response_to1.14303243
86MP0005000_abnormal_immune_tolerance1.13257645
87MP0004883_abnormal_blood_vessel1.12650837
88MP0000747_muscle_weakness1.12225744
89MP0004130_abnormal_muscle_cell1.10666226
90MP0010630_abnormal_cardiac_muscle1.10210026
91MP0000647_abnormal_sebaceous_gland1.09788558
92MP0002060_abnormal_skin_morphology1.08691229
93MP0003183_abnormal_peptide_metabolism1.07983084
94MP0004742_abnormal_vestibular_system1.07385168
95MP0000604_amyloidosis1.06874762
96MP0003941_abnormal_skin_development1.05488935
97MP0003045_fibrosis1.03164147
98MP0005390_skeleton_phenotype1.02835300
99MP0001853_heart_inflammation1.02499818
100MP0002332_abnormal_exercise_endurance1.02165412
101MP0003221_abnormal_cardiomyocyte_apopto1.02107814
102MP0000858_altered_metastatic_potential1.02075584
103MP0000762_abnormal_tongue_morphology1.01849017
104MP0008004_abnormal_stomach_pH1.00790256
105MP0003566_abnormal_cell_adhesion1.00589054
106MP0005025_abnormal_response_to0.99547413
107MP0000689_abnormal_spleen_morphology0.99280738
108MP0002429_abnormal_blood_cell0.97761040
109MP0003634_abnormal_glial_cell0.96065307
110MP0003866_abnormal_defecation0.95458072
111MP0003075_altered_response_to0.94664799
112MP0000467_abnormal_esophagus_morphology0.93635968
113MP0001663_abnormal_digestive_system0.91090879
114MP0005167_abnormal_blood-brain_barrier0.90997681
115MP0002098_abnormal_vibrissa_morphology0.90555521
116MP0008874_decreased_physiological_sensi0.89734673
117MP0004085_abnormal_heartbeat0.89458986
118MP0002722_abnormal_immune_system0.88844212
119MP0005171_absent_coat_pigmentation0.88625989
120MP0008569_lethality_at_weaning0.88447804
121MP0002295_abnormal_pulmonary_circulatio0.88437317
122MP0000759_abnormal_skeletal_muscle0.88397577
123MP0000685_abnormal_immune_system0.88084432
124MP0003633_abnormal_nervous_system0.86660451
125MP0009765_abnormal_xenobiotic_induced0.86488355
126MP0004782_abnormal_surfactant_physiolog0.85090877
127MP0004142_abnormal_muscle_tone0.84686636
128MP0009333_abnormal_splenocyte_physiolog0.84677193
129MP0003879_abnormal_hair_cell0.84637070
130MP0009840_abnormal_foam_cell0.84142230
131MP0005388_respiratory_system_phenotype0.84035598
132MP0002133_abnormal_respiratory_system0.84035598
133MP0000377_abnormal_hair_follicle0.84006115
134MP0003436_decreased_susceptibility_to0.82247125
135MP0003136_yellow_coat_color0.82239613
136MP0002006_tumorigenesis0.81706062
137MP0000750_abnormal_muscle_regeneration0.81435471
138MP0003631_nervous_system_phenotype0.80952978
139MP0001905_abnormal_dopamine_level0.80692361
140MP0005671_abnormal_response_to0.80648941
141MP0001533_abnormal_skeleton_physiology0.80511640
142MP0003195_calcinosis0.79806654
143MP0001346_abnormal_lacrimal_gland0.78296125
144MP0002138_abnormal_hepatobiliary_system0.77651566
145MP0002933_joint_inflammation0.77557609
146MP0002419_abnormal_innate_immunity0.77285804
147MP0010234_abnormal_vibrissa_follicle0.75894037
148MP0009763_increased_sensitivity_to0.75542105
149MP0003448_altered_tumor_morphology0.74712242
150MP0000569_abnormal_digit_pigmentation0.73171831
151MP0002132_abnormal_respiratory_system0.71698447
152MP0002064_seizures0.67787558
153MP0005535_abnormal_body_temperature0.65645273
154MP0001542_abnormal_bone_strength0.65488217
155MP0006054_spinal_hemorrhage0.64475517
156MP0003656_abnormal_erythrocyte_physiolo0.63874657
157MP0002653_abnormal_ependyma_morphology0.61823606
158MP0000703_abnormal_thymus_morphology0.61382524
159MP0009745_abnormal_behavioral_response0.59679277
160MP0000249_abnormal_blood_vessel0.58799211
161MP0002254_reproductive_system_inflammat0.56779905
162MP0001970_abnormal_pain_threshold0.54963793
163MP0005381_digestive/alimentary_phenotyp0.54318057
164MP0001986_abnormal_taste_sensitivity0.54132348

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)5.89629802
2Optic neuritis (HP:0100653)5.86049634
3Retrobulbar optic neuritis (HP:0100654)5.86049634
4Myositis (HP:0100614)5.80876015
5Eczematoid dermatitis (HP:0000976)5.26627095
6Muscle fiber splitting (HP:0003555)4.99959531
7Abnormality of macrophages (HP:0004311)4.78554614
8Parakeratosis (HP:0001036)4.65731474
9Hyporeflexia of lower limbs (HP:0002600)4.57892452
10Neurofibrillary tangles (HP:0002185)4.27955162
11Keratoconjunctivitis sicca (HP:0001097)4.22816267
12Ventricular tachycardia (HP:0004756)4.22244317
13Sudden death (HP:0001699)4.20573011
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.99274372
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.99274372
16Keratoconjunctivitis (HP:0001096)3.96927201
17Abnormality of liposaccharide metabolism (HP:0010968)3.95990555
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.95990555
19Abnormality of glycolipid metabolism (HP:0010969)3.95990555
20Recurrent gram-negative bacterial infections (HP:0005420)3.94950327
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.85883529
22Calf muscle hypertrophy (HP:0008981)3.67575383
23Mediastinal lymphadenopathy (HP:0100721)3.60274175
24Muscle hypertrophy of the lower extremities (HP:0008968)3.60246155
25Hypokalemic alkalosis (HP:0001949)3.45742799
26Increased circulating renin level (HP:0000848)3.36231613
27Recurrent fungal infections (HP:0002841)3.32555005
28Metabolic alkalosis (HP:0200114)3.29535286
29Difficulty running (HP:0009046)3.26494922
30Autoimmune thrombocytopenia (HP:0001973)3.26320704
31Segmental peripheral demyelination/remyelination (HP:0003481)3.25466451
32Pulmonary infiltrates (HP:0002113)3.22567122
33Right ventricular cardiomyopathy (HP:0011663)3.21229799
34Gastrointestinal infarctions (HP:0005244)3.19602686
35Recurrent skin infections (HP:0001581)3.18227807
36Axonal loss (HP:0003447)3.17552763
37Hemoptysis (HP:0002105)3.13284269
38Congenital ichthyosiform erythroderma (HP:0007431)3.12455355
39Onion bulb formation (HP:0003383)3.11272236
40Abnormal delayed hypersensitivity skin test (HP:0002963)3.10182550
41Exercise-induced myalgia (HP:0003738)3.10162221
42Increased cerebral lipofuscin (HP:0011813)3.09798935
43Abnormality of the calf musculature (HP:0001430)3.08423667
44Vasculitis (HP:0002633)3.06920194
45Atrial fibrillation (HP:0005110)3.05990817
46Encephalitis (HP:0002383)3.04656779
47Peripheral hypomyelination (HP:0007182)2.99537436
48Cerebral inclusion bodies (HP:0100314)2.99097836
49Abnormality of the corticospinal tract (HP:0002492)2.96050365
50Episodic fever (HP:0001954)2.95293868
51Gingivitis (HP:0000230)2.93123914
52Hypomagnesemia (HP:0002917)2.91404484
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.91167730
54Obstructive lung disease (HP:0006536)2.87477434
55Chronic obstructive pulmonary disease (HP:0006510)2.87477434
56Meningitis (HP:0001287)2.87145118
57Primary atrial arrhythmia (HP:0001692)2.85061996
58Dysostosis multiplex (HP:0000943)2.85027494
59Amyloidosis (HP:0011034)2.78816295
60Loss of speech (HP:0002371)2.76353476
61Termporal pattern (HP:0011008)2.74182852
62Insidious onset (HP:0003587)2.74182852
63Hypotrichosis (HP:0001006)2.70264634
64Supraventricular tachycardia (HP:0004755)2.69084840
65Stomatitis (HP:0010280)2.66253691
66Supraventricular arrhythmia (HP:0005115)2.66232255
67Increased IgM level (HP:0003496)2.65349687
68Urticaria (HP:0001025)2.64239880
69Cerebral hemorrhage (HP:0001342)2.63760675
70Arterial thrombosis (HP:0004420)2.61859948
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.60925923
72Disinhibition (HP:0000734)2.60538950
73Syncope (HP:0001279)2.60101931
74Vertigo (HP:0002321)2.59795694
75EMG: myopathic abnormalities (HP:0003458)2.59330542
76Foot dorsiflexor weakness (HP:0009027)2.59005193
77Leukocytosis (HP:0001974)2.56672395
78Gangrene (HP:0100758)2.56525657
79Prolonged bleeding time (HP:0003010)2.54657544
80Spontaneous hematomas (HP:0007420)2.54125538
81Hypoplasia of the iris (HP:0007676)2.49309229
82Ankle clonus (HP:0011448)2.47622928
83Chronic mucocutaneous candidiasis (HP:0002728)2.46525527
84Recurrent cutaneous fungal infections (HP:0011370)2.46525527
85Lipoatrophy (HP:0100578)2.42970529
86Exercise-induced muscle cramps (HP:0003710)2.42385822
87Anorexia (HP:0002039)2.40861224
88Abnormality of the foot musculature (HP:0001436)2.40682703
89Chest pain (HP:0100749)2.39319120
90Abnormality of T cell number (HP:0011839)2.39030058
91Supranuclear gaze palsy (HP:0000605)2.38674042
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38156691
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38156691
94Abnormality of polysaccharide metabolism (HP:0011012)2.38156691
95Mutism (HP:0002300)2.36317545
96Pulmonary embolism (HP:0002204)2.34087841
97Peritonitis (HP:0002586)2.33951695
98T lymphocytopenia (HP:0005403)2.33707396
99Alveolar cell carcinoma (HP:0006519)2.32145071
100Systemic lupus erythematosus (HP:0002725)2.26331769
101Gowers sign (HP:0003391)2.24549340
102Neoplasm of the tracheobronchial system (HP:0100552)2.23713979
103Diplopia (HP:0000651)2.23500711
104Abnormality of binocular vision (HP:0011514)2.23500711
105Hyperaldosteronism (HP:0000859)2.22811091
106Hypergammaglobulinemia (HP:0010702)2.22809714
107Abnormality of the pleura (HP:0002103)2.21548806
108Abnormality of the endocardium (HP:0004306)2.21333815
109Neck muscle weakness (HP:0000467)2.21300809
110Abnormality of chloride homeostasis (HP:0011422)2.20555808
111Abnormal auditory evoked potentials (HP:0006958)2.20369372
112Vacuolated lymphocytes (HP:0001922)2.19875792
113Pustule (HP:0200039)2.19365922
114Diaphragmatic weakness (HP:0009113)2.18547323
115Keratitis (HP:0000491)2.16640626
116Stridor (HP:0010307)2.16144526
117Abnormality of the salivary glands (HP:0010286)2.16101349
118Erythroderma (HP:0001019)2.15831349
119Mucopolysacchariduria (HP:0008155)2.15244324
120Urinary glycosaminoglycan excretion (HP:0003541)2.15244324
121Abnormality of magnesium homeostasis (HP:0004921)2.14698821
122Ventricular fibrillation (HP:0001663)2.14295388
123Elevated erythrocyte sedimentation rate (HP:0003565)2.13173679
124Prolonged QT interval (HP:0001657)2.12908103
125Palmoplantar keratoderma (HP:0000982)2.12736279
126Hypochromic microcytic anemia (HP:0004840)2.12125400
127Increased IgE level (HP:0003212)2.11165166
128Increased serum ferritin (HP:0003281)2.10611660
129Abnormality of the pericardium (HP:0001697)2.10459665
130Abnormality of the left ventricular outflow tract (HP:0011103)2.09910228
131Subaortic stenosis (HP:0001682)2.09910228
132Agitation (HP:0000713)2.09827776
133Abnormality of renin-angiotensin system (HP:0000847)2.09603016
134Hematochezia (HP:0002573)2.09010080
135Hypochromic anemia (HP:0001931)2.07536376
136Abnormal drinking behavior (HP:0030082)2.05692613
137Polydipsia (HP:0001959)2.05692613
138Hemiplegia (HP:0002301)2.04261923
139Renal salt wasting (HP:0000127)2.03091391
140Purpura (HP:0000979)2.02337180
141Hyperactive renin-angiotensin system (HP:0000841)2.01973962
142Acne (HP:0001061)2.01796502
143Polyneuropathy (HP:0001271)2.00180538
144Memory impairment (HP:0002354)1.99111985
145Dilated cardiomyopathy (HP:0001644)1.97763286
146Gingival bleeding (HP:0000225)1.97573968
147Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96708569
148Inappropriate behavior (HP:0000719)1.96074477
149Plantar hyperkeratosis (HP:0007556)1.95787996
150Slow saccadic eye movements (HP:0000514)1.95688115
151Polyuria (HP:0000103)1.94093886
152Thick nail (HP:0001805)1.93111143
153Conical tooth (HP:0000698)1.91443117
154Petechiae (HP:0000967)1.91271761
155Progressive neurologic deterioration (HP:0002344)1.90918202
156Fragile nails (HP:0001808)1.90861729
157Aplasia involving bones of the upper limbs (HP:0009823)1.90746427
158Aplasia of the phalanges of the hand (HP:0009802)1.90746427
159Aplasia involving bones of the extremities (HP:0009825)1.90746427
160Rapidly progressive (HP:0003678)1.88290622
161Steppage gait (HP:0003376)1.88082813
162Epistaxis (HP:0000421)1.87771485
163Obstructive sleep apnea (HP:0002870)1.87236432
164Interstitial pulmonary disease (HP:0006530)1.86052461
165Eosinophilia (HP:0001880)1.85574150
166Distal lower limb muscle weakness (HP:0009053)1.85372023
167Recurrent viral infections (HP:0004429)1.83433833
168Abnormality of iron homeostasis (HP:0011031)1.81751619
169Autoimmune hemolytic anemia (HP:0001890)1.80928778
170Stomach cancer (HP:0012126)1.80824996
171Erythema (HP:0010783)1.79381284
172Dysmetria (HP:0001310)1.78796549
173Ulnar claw (HP:0001178)1.78495083
174Chronic otitis media (HP:0000389)1.78218451
175Increased serum pyruvate (HP:0003542)1.78171371
176Abnormality of glycolysis (HP:0004366)1.78171371
177Abnormality of renal excretion (HP:0011036)1.77464655
178Difficulty walking (HP:0002355)1.77367686
179Anhidrosis (HP:0000970)1.77329026
180Intention tremor (HP:0002080)1.73319993
181Spastic tetraparesis (HP:0001285)1.73130039
182Abnormal urine output (HP:0012590)1.72736374
183Recurrent bacterial skin infections (HP:0005406)1.71446024
184Recurrent abscess formation (HP:0002722)1.70851539
185Milia (HP:0001056)1.69818181
186Premature skin wrinkling (HP:0100678)1.69460747
187Lip pit (HP:0100267)1.67823455
188Pterygium (HP:0001059)1.66402125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.94353654
2EPHB14.03898402
3MAPKAPK53.41678275
4WNK43.41480960
5OXSR13.21527852
6MAP4K12.60767441
7IRAK42.53498727
8PKN12.38556247
9PBK2.29661665
10DMPK1.99942369
11FES1.98713769
12MST41.96944202
13TTN1.94254571
14MAP2K31.85597443
15PHKG21.83308604
16PHKG11.83308604
17MUSK1.78077896
18MAP3K111.72792251
19ZAP701.72452512
20PRPF4B1.71605839
21WNK11.68261757
22TNK21.67609480
23IRAK31.66298406
24ERN11.56854650
25RIPK11.48469931
26OBSCN1.44413659
27DAPK21.44393436
28MATK1.43423929
29SYK1.42546849
30TRPM71.40860893
31IRAK11.40020012
32GRK61.39548937
33GRK71.35536208
34TIE11.32626377
35MAP3K61.31078027
36PRKD11.25778337
37LIMK11.22999065
38BTK1.20082162
39LYN1.19983861
40MARK21.19543545
41TAOK21.18678505
42ROCK21.18001553
43MARK31.16822729
44ADRBK21.15287686
45EPHA31.14106278
46FGFR21.13833445
47MOS1.11762760
48JAK21.09855134
49IRAK21.08779932
50NTRK11.08738043
51MAP3K141.08676894
52KIT1.05494912
53FRK1.01860674
54MET1.01493936
55PIM21.01260747
56CSF1R1.00701068
57JAK31.00223981
58DYRK20.99239426
59FGR0.98998651
60TYK20.98763230
61SIK20.98751895
62CLK10.97628391
63BMPR20.97521021
64TYRO30.93736395
65CAMK2D0.91935264
66CDC42BPA0.91446624
67MST1R0.91103299
68PAK30.87445205
69SGK2230.84521743
70SGK4940.84521743
71MYLK0.83357625
72IKBKE0.82685572
73TBK10.81863762
74CAMK2A0.80970808
75CSNK1G30.79081705
76SIK30.78386986
77FER0.77748956
78UHMK10.77215597
79PDK10.76781592
80WNK30.76757629
81BLK0.76616524
82STK240.76550698
83BCR0.76393908
84PRKD20.76175639
85CSNK1A1L0.76073254
86MAP3K10.74232572
87CAMKK20.73990205
88RIPK40.73727424
89CAMK2B0.73062447
90PRKCQ0.72876497
91PRKCE0.70825606
92ILK0.70720637
93LRRK20.69477096
94STK100.69250357
95KSR20.68966980
96MAP3K20.68363017
97CAMKK10.68287436
98PTK2B0.68256499
99MAP3K120.67802442
100CHUK0.67564020
101MAP2K60.66978612
102CSNK1G20.66970719
103TXK0.66793683
104ITK0.66699891
105PRKD30.66377326
106CSNK1G10.65457263
107CSK0.64671734
108PAK60.63588607
109SGK30.63385321
110GSK3A0.63109467
111MAPK70.63010990
112BMPR1B0.62793370
113ABL20.61230136
114SGK20.60907892
115JAK10.60700587
116TEC0.60588885
117MAP3K130.60088089
118CAMK10.59516579
119RPS6KA60.58077110
120LMTK20.57830226
121YES10.57355246
122NTRK20.56366149
123HIPK20.56363354
124PINK10.56244022
125STK380.56091994
126PIK3CA0.55325615
127ACVR1B0.55272016
128RPS6KC10.53237097
129RPS6KL10.53237097
130MAP3K50.53088987
131PDPK10.52452876
132HCK0.52347846
133LCK0.50959735
134DDR20.49508539
135MAPKAPK20.48480185
136RPS6KA20.48108454
137CAMK40.46889078
138CAMK2G0.46756634
139MAP3K90.46375696
140TAOK30.46324633
141TAOK10.45266714
142ABL10.44912574
143MAPK120.44387782
144PIM10.44361280
145MAP3K30.44177981
146PDGFRB0.43920085
147STK110.43678648
148FYN0.43532131
149PRKCZ0.43255965
150IKBKB0.42669472
151ADRBK10.41519743
152TGFBR20.41513482
153NTRK30.41376845
154MAPK40.38401615

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000622.97481522
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.71568617
3Staphylococcus aureus infection_Homo sapiens_hsa051502.38395449
4Ether lipid metabolism_Homo sapiens_hsa005652.35749523
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09595691
6Dilated cardiomyopathy_Homo sapiens_hsa054141.79216582
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.73007099
8Cardiac muscle contraction_Homo sapiens_hsa042601.66532697
9Sphingolipid metabolism_Homo sapiens_hsa006001.64981428
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55193510
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52610953
12Viral myocarditis_Homo sapiens_hsa054161.51306038
13Steroid biosynthesis_Homo sapiens_hsa001001.50990910
14Linoleic acid metabolism_Homo sapiens_hsa005911.50919206
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50498147
16Graft-versus-host disease_Homo sapiens_hsa053321.49545450
17B cell receptor signaling pathway_Homo sapiens_hsa046621.49540270
18Dorso-ventral axis formation_Homo sapiens_hsa043201.49448756
19Allograft rejection_Homo sapiens_hsa053301.46788750
20Legionellosis_Homo sapiens_hsa051341.45767120
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42200078
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41786377
23Oxidative phosphorylation_Homo sapiens_hsa001901.35493284
24Lysosome_Homo sapiens_hsa041421.34528559
25Ovarian steroidogenesis_Homo sapiens_hsa049131.29895747
26Influenza A_Homo sapiens_hsa051641.29702609
27Rheumatoid arthritis_Homo sapiens_hsa053231.22888551
28Sphingolipid signaling pathway_Homo sapiens_hsa040711.22193439
29Other glycan degradation_Homo sapiens_hsa005111.17328541
30Leishmaniasis_Homo sapiens_hsa051401.17095144
31Alzheimers disease_Homo sapiens_hsa050101.16977765
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15646122
33Parkinsons disease_Homo sapiens_hsa050121.14645385
34Gastric acid secretion_Homo sapiens_hsa049711.13348255
35Primary immunodeficiency_Homo sapiens_hsa053401.10956623
36Renal cell carcinoma_Homo sapiens_hsa052111.10503168
37Malaria_Homo sapiens_hsa051441.09562800
38Serotonergic synapse_Homo sapiens_hsa047261.09241075
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07981945
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.07947059
41Axon guidance_Homo sapiens_hsa043601.07188205
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.07103308
43Antigen processing and presentation_Homo sapiens_hsa046121.05863070
44Arachidonic acid metabolism_Homo sapiens_hsa005901.03683473
45Salmonella infection_Homo sapiens_hsa051321.02084986
46Histidine metabolism_Homo sapiens_hsa003401.01331456
47VEGF signaling pathway_Homo sapiens_hsa043701.00203834
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00164996
49Acute myeloid leukemia_Homo sapiens_hsa052210.97977916
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95824138
51Long-term depression_Homo sapiens_hsa047300.95699885
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95057548
53Toxoplasmosis_Homo sapiens_hsa051450.94529074
54Renin secretion_Homo sapiens_hsa049240.94184044
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93740294
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.93373221
57Amoebiasis_Homo sapiens_hsa051460.93017312
58Herpes simplex infection_Homo sapiens_hsa051680.92401996
59ECM-receptor interaction_Homo sapiens_hsa045120.92098673
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89189518
61Chemokine signaling pathway_Homo sapiens_hsa040620.88465373
62Hepatitis B_Homo sapiens_hsa051610.88064585
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.87640309
64Tight junction_Homo sapiens_hsa045300.85795688
65Ras signaling pathway_Homo sapiens_hsa040140.85762904
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85230400
67Autoimmune thyroid disease_Homo sapiens_hsa053200.83596286
68Pertussis_Homo sapiens_hsa051330.83253596
69Asthma_Homo sapiens_hsa053100.82949882
70Type II diabetes mellitus_Homo sapiens_hsa049300.82555405
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82102452
72Platelet activation_Homo sapiens_hsa046110.81784825
73Osteoclast differentiation_Homo sapiens_hsa043800.80785804
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80019403
75TNF signaling pathway_Homo sapiens_hsa046680.79239207
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78199836
77GnRH signaling pathway_Homo sapiens_hsa049120.77859591
78Morphine addiction_Homo sapiens_hsa050320.77628495
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76595528
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75618760
81Shigellosis_Homo sapiens_hsa051310.75100433
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74710377
83African trypanosomiasis_Homo sapiens_hsa051430.74453164
84Glutamatergic synapse_Homo sapiens_hsa047240.74009328
85Mineral absorption_Homo sapiens_hsa049780.71301106
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.70826131
87Phagosome_Homo sapiens_hsa041450.69773369
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69094767
89Collecting duct acid secretion_Homo sapiens_hsa049660.68207463
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67802429
91Prolactin signaling pathway_Homo sapiens_hsa049170.67674565
92Apoptosis_Homo sapiens_hsa042100.67004265
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66787120
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.65836486
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65309907
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65297914
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.63685858
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63670242
99Pancreatic secretion_Homo sapiens_hsa049720.62775775
100Endocytosis_Homo sapiens_hsa041440.62686727
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.62385691
102MAPK signaling pathway_Homo sapiens_hsa040100.62164814
103Pancreatic cancer_Homo sapiens_hsa052120.62161950
104Focal adhesion_Homo sapiens_hsa045100.61380743
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60921073
106Salivary secretion_Homo sapiens_hsa049700.60763665
107Tuberculosis_Homo sapiens_hsa051520.59681490
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59564478
109T cell receptor signaling pathway_Homo sapiens_hsa046600.58733265
110Notch signaling pathway_Homo sapiens_hsa043300.58094843
111cAMP signaling pathway_Homo sapiens_hsa040240.57628713
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57542141
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57252200
114Choline metabolism in cancer_Homo sapiens_hsa052310.57173173
115Hepatitis C_Homo sapiens_hsa051600.56981211
116Cocaine addiction_Homo sapiens_hsa050300.56121463
117Type I diabetes mellitus_Homo sapiens_hsa049400.55610298
118ErbB signaling pathway_Homo sapiens_hsa040120.55451501
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.55279400
120Oxytocin signaling pathway_Homo sapiens_hsa049210.55244878
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54830068
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54157568
123Hematopoietic cell lineage_Homo sapiens_hsa046400.53702364
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52959072
125Synaptic vesicle cycle_Homo sapiens_hsa047210.52748280
126Circadian entrainment_Homo sapiens_hsa047130.52501872
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52251295
128Measles_Homo sapiens_hsa051620.51490823
129Rap1 signaling pathway_Homo sapiens_hsa040150.50751711
130FoxO signaling pathway_Homo sapiens_hsa040680.49558829
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48984929
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47177252
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41052255
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41021665
135mTOR signaling pathway_Homo sapiens_hsa041500.39481458
136Insulin resistance_Homo sapiens_hsa049310.38658343
137Calcium signaling pathway_Homo sapiens_hsa040200.38462374
138Cholinergic synapse_Homo sapiens_hsa047250.37907277

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