SLCO4C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemical homeostasis within a tissue (GO:0048875)9.41514897
2vitamin transmembrane transport (GO:0035461)7.12602918
3intestinal epithelial cell development (GO:0060576)6.80772806
4positive regulation by symbiont of host defense response (GO:0052509)5.79436857
5modulation by symbiont of host defense response (GO:0052031)5.79436857
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.79436857
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.79436857
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.79436857
9modulation by symbiont of host immune response (GO:0052553)5.79436857
10detection of molecule of bacterial origin (GO:0032490)5.44713261
11positive regulation of gamma-delta T cell activation (GO:0046645)5.20458695
12cellular extravasation (GO:0045123)5.13026812
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.00942668
14calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.96607882
15lung-associated mesenchyme development (GO:0060484)4.91068520
16response to xenobiotic stimulus (GO:0009410)4.81328327
17leukocyte migration involved in inflammatory response (GO:0002523)4.80637517
18regulation of B cell receptor signaling pathway (GO:0050855)4.78482025
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.74874161
20negative regulation of cell killing (GO:0031342)4.74874161
21neutrophil activation involved in immune response (GO:0002283)4.62827525
22cellular response to nitric oxide (GO:0071732)4.60911500
23macrophage activation involved in immune response (GO:0002281)4.51567481
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.50698720
25detection of other organism (GO:0098543)4.50190880
26detection of external biotic stimulus (GO:0098581)4.49130421
27microglial cell activation (GO:0001774)4.44684309
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.42952836
29pattern specification involved in kidney development (GO:0061004)4.33169316
30epithelial cell differentiation involved in prostate gland development (GO:0060742)4.31155681
31response to host immune response (GO:0052572)4.27748232
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.27748232
33purine nucleobase biosynthetic process (GO:0009113)4.24853118
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.21107287
35branching involved in prostate gland morphogenesis (GO:0060442)4.18123427
36regulation of interferon-beta biosynthetic process (GO:0045357)4.18081593
37mitotic metaphase plate congression (GO:0007080)4.10896655
38response to interleukin-15 (GO:0070672)4.10481292
39UDP-N-acetylglucosamine metabolic process (GO:0006047)4.03125254
40tight junction assembly (GO:0070830)4.02977322
41regulation of gamma-delta T cell activation (GO:0046643)4.00338763
42regulation of hippo signaling (GO:0035330)3.97120813
43detection of biotic stimulus (GO:0009595)3.94455829
44neutrophil activation (GO:0042119)3.93728303
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.92279806
46response to host (GO:0075136)3.92279806
47response to host defenses (GO:0052200)3.92279806
48lung lobe morphogenesis (GO:0060463)3.91652537
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.90800501
50response to peptidoglycan (GO:0032494)3.87935293
51negative regulation of B cell mediated immunity (GO:0002713)3.87289376
52negative regulation of immunoglobulin mediated immune response (GO:0002890)3.87289376
53neutrophil mediated immunity (GO:0002446)3.87184521
54detection of bacterium (GO:0016045)3.87003038
55regulation of gamma-delta T cell differentiation (GO:0045586)3.85366820
56sphingosine metabolic process (GO:0006670)3.84190381
57leukocyte aggregation (GO:0070486)3.80568479
58macrophage activation (GO:0042116)3.80562489
59cellular response to reactive nitrogen species (GO:1902170)3.74187941
60negative regulation of fibroblast apoptotic process (GO:2000270)3.72672408
61pantothenate metabolic process (GO:0015939)3.71362310
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.69423820
63prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.67632777
64respiratory burst (GO:0045730)3.67465403
65production of molecular mediator involved in inflammatory response (GO:0002532)3.66894701
66negative regulation of protein activation cascade (GO:2000258)3.63626865
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.61945739
68peptide catabolic process (GO:0043171)3.60003357
69regulation of spindle organization (GO:0090224)3.59077418
70negative regulation of complement activation (GO:0045916)3.58184035
71modified amino acid transport (GO:0072337)3.54021543
72negative regulation of humoral immune response (GO:0002921)3.52816867
73pyrimidine-containing compound transmembrane transport (GO:0072531)3.52704189
74diol metabolic process (GO:0034311)3.51641248
75lung secretory cell differentiation (GO:0061140)3.48614210
76cellular response to interleukin-15 (GO:0071350)3.47977236
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47717881
78sulfur compound transport (GO:0072348)3.45865409
79vitamin transport (GO:0051180)3.44304729
80antigen processing and presentation of endogenous antigen (GO:0019883)3.43023117
81regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.42911980
82folic acid metabolic process (GO:0046655)3.42466564
83folic acid transport (GO:0015884)3.41280154
84granulocyte activation (GO:0036230)3.40140857
85ectodermal placode formation (GO:0060788)3.38386332
86response to nitric oxide (GO:0071731)3.37988543
87one-carbon compound transport (GO:0019755)3.37636285
88trivalent inorganic anion homeostasis (GO:0072506)3.35726083
89phosphate ion homeostasis (GO:0055062)3.35726083
90cysteine metabolic process (GO:0006534)3.35097503
91positive regulation of Cdc42 GTPase activity (GO:0043089)3.32996485
92myeloid leukocyte mediated immunity (GO:0002444)3.31833152
93positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30170677
94regulation of interleukin-8 biosynthetic process (GO:0045414)3.29205523
95nucleobase biosynthetic process (GO:0046112)3.28729868
96response to mercury ion (GO:0046689)3.26658094
97negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.25542861
98dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.24946149
99myeloid cell activation involved in immune response (GO:0002275)3.23711573
100negative regulation of interleukin-12 production (GO:0032695)3.22026501
101B cell receptor signaling pathway (GO:0050853)3.20571759
102ribosome assembly (GO:0042255)3.19329871
103negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13895136
104negative regulation of leukocyte mediated immunity (GO:0002704)3.13363190
105negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11531802
106regulation of protein activation cascade (GO:2000257)3.09863927
107regulation of complement activation (GO:0030449)3.08896385
108nucleotide-sugar biosynthetic process (GO:0009226)3.08893869
109anterior/posterior axis specification, embryo (GO:0008595)3.07434158
110sphingoid metabolic process (GO:0046519)3.07420335
111negative regulation of transcription by competitive promoter binding (GO:0010944)3.07189076
112negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.05286322
113spindle assembly involved in mitosis (GO:0090307)3.04526882
114regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.03731248
115establishment of apical/basal cell polarity (GO:0035089)3.01541693
116CDP-diacylglycerol metabolic process (GO:0046341)3.00364272
117positive regulation of chromosome segregation (GO:0051984)2.99620778
118antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99148068
119regulation of B cell differentiation (GO:0045577)2.98222341
120response to nitrosative stress (GO:0051409)2.97644961
121negative regulation of B cell proliferation (GO:0030889)2.97615008
122positive regulation of mast cell activation (GO:0033005)2.97261923
123neutrophil migration (GO:1990266)2.96630303
124xenobiotic catabolic process (GO:0042178)2.96412046
125DNA damage response, signal transduction resulting in transcription (GO:0042772)2.95028588
126antigen processing and presentation via MHC class Ib (GO:0002475)2.93959207
127positive regulation of toll-like receptor signaling pathway (GO:0034123)2.93800839
128regulation of G0 to G1 transition (GO:0070316)2.92379232
129positive regulation of interferon-alpha production (GO:0032727)2.92350368
130dendritic cell migration (GO:0036336)2.91574641
131metaphase plate congression (GO:0051310)2.91032915
132phosphate ion transmembrane transport (GO:0035435)2.90967828
133killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.90602991
134disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.90602991
135regulation of mast cell degranulation (GO:0043304)2.90315270
136negative regulation of T cell mediated immunity (GO:0002710)2.89942702
137negative regulation of adaptive immune response (GO:0002820)2.89855311
138positive regulation of B cell differentiation (GO:0045579)2.87988035
139regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86106382
140neutrophil chemotaxis (GO:0030593)2.84862623
141negative regulation of fibrinolysis (GO:0051918)2.84533285
142epithelial cell maturation (GO:0002070)2.84494335
143regulation of mast cell activation (GO:0033003)2.83942387
144negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82872261
145negative regulation of T-helper cell differentiation (GO:0045623)2.82872261
146negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.82446416
147positive regulation of endothelial cell differentiation (GO:0045603)2.82316748
148regulation of mast cell activation involved in immune response (GO:0033006)2.80296588
149replicative senescence (GO:0090399)2.79923247
150hepatocyte apoptotic process (GO:0097284)2.79155961
151columnar/cuboidal epithelial cell development (GO:0002066)2.78093062
152positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.77950698
153branching involved in labyrinthine layer morphogenesis (GO:0060670)2.76798672
154cell wall macromolecule catabolic process (GO:0016998)2.76057145
155positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.75824053
156response to interleukin-6 (GO:0070741)2.74637699
157regulation of translation in response to stress (GO:0043555)2.74275494
158immunoglobulin mediated immune response (GO:0016064)2.73042510
159polyol transport (GO:0015791)2.72168592
160superoxide anion generation (GO:0042554)2.71971244
161negative regulation of Ras GTPase activity (GO:0034261)2.71872931
162prostate gland epithelium morphogenesis (GO:0060740)2.71550647
163plasma lipoprotein particle assembly (GO:0034377)2.71402029
164very-low-density lipoprotein particle assembly (GO:0034379)2.68566221
165regulation of mitotic spindle organization (GO:0060236)2.68219820
166regulation of receptor binding (GO:1900120)2.68170271
167regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.67885048
168regulation of tolerance induction (GO:0002643)2.67564368
169hormone catabolic process (GO:0042447)2.66893069
170establishment or maintenance of monopolar cell polarity (GO:0061339)2.65662934
171establishment of monopolar cell polarity (GO:0061162)2.65662934
172myeloid leukocyte activation (GO:0002274)2.64703630
173leukocyte degranulation (GO:0043299)2.63664388
174sulfur amino acid catabolic process (GO:0000098)2.63031346
175positive regulation of cellular amide metabolic process (GO:0034250)2.62542307
176regulation of histone H3-K27 methylation (GO:0061085)2.62392997
177regulation of interferon-alpha production (GO:0032647)2.62304444
178microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.62024947
179epithelial tube branching involved in lung morphogenesis (GO:0060441)2.61937445
180DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.61716371
181autophagic vacuole assembly (GO:0000045)2.61089722
182sequestering of metal ion (GO:0051238)2.60889515
183negative regulation of fatty acid transport (GO:2000192)2.60484080
184centrosome localization (GO:0051642)2.59822862
185regulation of establishment or maintenance of cell polarity (GO:0032878)2.58991002
186mannose metabolic process (GO:0006013)2.58749132
187regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.57284770
188ectoderm development (GO:0007398)2.56918262
189artery development (GO:0060840)2.56035903
190cellular anion homeostasis (GO:0030002)2.55669410
191protein localization to endosome (GO:0036010)2.54199559
192regulation of establishment of cell polarity (GO:2000114)2.54044951
193blastocyst development (GO:0001824)2.52890322
194S-adenosylmethionine metabolic process (GO:0046500)2.52401678
195segment specification (GO:0007379)2.51815591
196phosphate ion transport (GO:0006817)2.51226794
197CDP-diacylglycerol biosynthetic process (GO:0016024)2.50735527
198regulation of phospholipid biosynthetic process (GO:0071071)2.50023308
199positive regulation of autophagy (GO:0010508)2.48623349
200surfactant homeostasis (GO:0043129)11.3435714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.32292477
2AR_21909140_ChIP-Seq_LNCAP_Human4.03334135
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.96979657
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.80888016
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.76701451
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.63584321
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.62664613
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.41344199
9E2F7_22180533_ChIP-Seq_HELA_Human3.32718331
10ZNF263_19887448_ChIP-Seq_K562_Human3.29017989
11ESR2_21235772_ChIP-Seq_MCF-7_Human3.12857806
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.07754692
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01216358
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97971832
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.94896617
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.86219879
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.85250247
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80606511
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78214195
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77843135
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.73548295
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73236910
23RUNX_20019798_ChIP-Seq_JUKART_Human2.69789602
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68990657
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.63312903
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.60826071
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58265689
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.50868167
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.50868167
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.50868167
31* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.46768019
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.46650252
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43243685
34NANOG_18555785_ChIP-Seq_MESCs_Mouse2.40752688
35* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.27510093
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25149229
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24589915
38SPI1_23547873_ChIP-Seq_NB4_Human2.21869511
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20355751
40MYB_26560356_Chip-Seq_TH2_Human2.19714337
41VDR_24787735_ChIP-Seq_THP-1_Human2.18286292
42* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.17256690
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.11342378
44SMAD_19615063_ChIP-ChIP_OVARY_Human2.10313530
45EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08339754
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.07985480
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03189481
48RUNX1_27514584_Chip-Seq_MCF-7_Human2.02779647
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02087922
50GATA4_25053715_ChIP-Seq_YYC3_Human2.01420033
51SCL_19346495_ChIP-Seq_HPC-7_Human1.98897140
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98364334
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.97032115
54SPI1_23127762_ChIP-Seq_K562_Human1.91256837
55* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.88109019
56CLOCK_20551151_ChIP-Seq_293T_Human1.87536876
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86151593
58GATA3_27048872_Chip-Seq_THYMUS_Human1.81703642
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79399941
60MYB_26560356_Chip-Seq_TH1_Human1.72413596
61GATA6_25053715_ChIP-Seq_YYC3_Human1.69850049
62* AHR_22903824_ChIP-Seq_MCF-7_Human1.67926896
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63594078
64GATA3_26560356_Chip-Seq_TH2_Human1.62483366
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61912482
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60321343
67* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.59269848
68NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.58123845
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.55415712
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55267911
71NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.55044402
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54712074
73GATA1_22025678_ChIP-Seq_K562_Human1.54373308
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54091466
75SOX2_20726797_ChIP-Seq_SW620_Human1.52571888
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51562296
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49690782
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.49570705
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49018624
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.48524051
81VDR_24763502_ChIP-Seq_THP-1_Human1.47423805
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45292215
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42312873
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41634994
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40792166
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39840743
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38688498
88* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38189767
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37718113
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37687668
91RACK7_27058665_Chip-Seq_MCF-7_Human1.37369746
92* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.37362583
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36535028
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36079918
95CHD1_26751641_Chip-Seq_LNCaP_Human1.35277346
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33659943
97NANOG_18692474_ChIP-Seq_MEFs_Mouse1.33417009
98TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32866274
99PU_27001747_Chip-Seq_BMDM_Mouse1.32094730
100* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30795207
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.30069073
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29300435
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29291837
104FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29167563
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28873941
106ESR1_20079471_ChIP-ChIP_T-47D_Human1.27030978
107GATA3_24758297_ChIP-Seq_MCF-7_Human1.26385639
108* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25507107
109TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.24732288
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23810295
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23646991
112KAP1_27257070_Chip-Seq_ESCs_Mouse1.23153628
113* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.23130566
114* E2F1_21310950_ChIP-Seq_MCF-7_Human1.21853037
115* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20631401
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20566275
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.20555556
118ATF3_27146783_Chip-Seq_COLON_Human1.20389427
119* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19037068
120MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19026861
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16943583
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16943583
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15173517
124MAF_26560356_Chip-Seq_TH1_Human1.15096777
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14736808
126FOXO3_23340844_ChIP-Seq_DLD1_Human1.14216117
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14053049
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13437127
129GATA2_21666600_ChIP-Seq_HMVEC_Human1.13220078
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12205730
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11995194
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11957577
133KDM5A_27292631_Chip-Seq_BREAST_Human1.11028633
134CDX2_20551321_ChIP-Seq_CACO-2_Human1.10709313
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09970948
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09887239
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09169409
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09039562
139* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08935308
140KLF5_25053715_ChIP-Seq_YYC3_Human1.08787472
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08721862
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08448810
143FLI1_27457419_Chip-Seq_LIVER_Mouse1.08157810
144RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07994680
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06995952
146ETS1_20019798_ChIP-Seq_JURKAT_Human1.06785753
147NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06669540
148PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06621407
149POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06010271
150* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05633148
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05066368
152PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04772024
153* NANOG_21062744_ChIP-ChIP_HESCs_Human1.04572859
154MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02974904
155CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02504514
156JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02242306
157MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01458267
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01279548
159PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01050775
160PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00601548
161UTX_26944678_Chip-Seq_JUKART_Human0.99621952
162CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99402210
163POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99012549
164* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98615654
165BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98372598
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96564656
167GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96480067
168SMRT_27268052_Chip-Seq_Bcells_Human0.96354446
169CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95645472
170ER_23166858_ChIP-Seq_MCF-7_Human0.95501415
171HNF4A_19822575_ChIP-Seq_HepG2_Human0.95133962
172ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93324849
173CDX2_22108803_ChIP-Seq_LS180_Human0.91557952
174LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91439632
175GATA2_19941826_ChIP-Seq_K562_Human0.91411353
176* EZH2_27294783_Chip-Seq_NPCs_Mouse0.89978047
177TCF4_18268006_ChIP-ChIP_LS174T_Human0.88490064
178POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88229604
179TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88229604
180* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88173008
181NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86634137
182AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86315976
183* SALL4_22934838_ChIP-ChIP_CD34+_Human0.85985481
184TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85892951
185* NFE2_27457419_Chip-Seq_LIVER_Mouse0.84863537
186GATA3_26560356_Chip-Seq_TH1_Human0.84398951
187MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82996962
188GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82783279
189* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80965128
190CEBPB_22108803_ChIP-Seq_LS180_Human0.80836607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.92773012
2MP0003724_increased_susceptibility_to4.50588514
3MP0003195_calcinosis4.10162729
4MP0008995_early_reproductive_senescence3.87587290
5MP0001958_emphysema3.81230422
6MP0010234_abnormal_vibrissa_follicle3.80303742
7MP0003693_abnormal_embryo_hatching3.56049870
8MP0005377_hearing/vestibular/ear_phenot3.15281264
9MP0003878_abnormal_ear_physiology3.15281264
10MP0003436_decreased_susceptibility_to2.90214657
11MP0001835_abnormal_antigen_presentation2.74041611
12MP0004264_abnormal_extraembryonic_tissu2.70018687
13MP0003718_maternal_effect2.67518591
14MP0003303_peritoneal_inflammation2.63258263
15MP0002419_abnormal_innate_immunity2.58024826
16MP0008004_abnormal_stomach_pH2.57881789
17MP0000537_abnormal_urethra_morphology2.48330922
18MP0003172_abnormal_lysosome_physiology2.45493462
19MP0003786_premature_aging2.33542461
20MP0008260_abnormal_autophagy2.32335025
21MP0005025_abnormal_response_to2.26982944
22MP0003252_abnormal_bile_duct2.25695292
23MP0009785_altered_susceptibility_to2.24788123
24MP0001800_abnormal_humoral_immune2.23226256
25MP0002132_abnormal_respiratory_system2.21092264
26MP0001177_atelectasis2.20554685
27MP0002139_abnormal_hepatobiliary_system2.18222593
28MP0000569_abnormal_digit_pigmentation2.17573294
29MP0005671_abnormal_response_to2.17294084
30MP0008789_abnormal_olfactory_epithelium2.07706757
31MP0005464_abnormal_platelet_physiology2.06643671
32MP0005085_abnormal_gallbladder_physiolo2.04951173
33MP0006082_CNS_inflammation2.04164459
34MP0005388_respiratory_system_phenotype2.03077734
35MP0002133_abnormal_respiratory_system2.03077734
36MP0003300_gastrointestinal_ulcer2.02596744
37MP0002277_abnormal_respiratory_mucosa1.97387696
38MP0002723_abnormal_immune_serum1.93385240
39MP0005365_abnormal_bile_salt1.93132044
40MP0004883_abnormal_blood_vessel1.89760023
41MP0005000_abnormal_immune_tolerance1.86934859
42MP0000685_abnormal_immune_system1.86168687
43MP0002452_abnormal_antigen_presenting1.84363718
44MP0010678_abnormal_skin_adnexa1.84322503
45MP0000566_synostosis1.83940371
46MP0002420_abnormal_adaptive_immunity1.83181940
47MP0005310_abnormal_salivary_gland1.81537018
48MP0001819_abnormal_immune_cell1.81486429
49MP0001790_abnormal_immune_system1.80967631
50MP0005387_immune_system_phenotype1.80967631
51MP0005394_taste/olfaction_phenotype1.75765012
52MP0005499_abnormal_olfactory_system1.75765012
53MP0002405_respiratory_system_inflammati1.68721193
54MP0005451_abnormal_body_composition1.58144105
55MP0003111_abnormal_nucleus_morphology1.56675986
56MP0002396_abnormal_hematopoietic_system1.56176209
57MP0005360_urolithiasis1.54032893
58MP0003763_abnormal_thymus_physiology1.53917420
59MP0010030_abnormal_orbit_morphology1.53869018
60MP0004957_abnormal_blastocyst_morpholog1.53794384
61MP0002098_abnormal_vibrissa_morphology1.53205434
62MP0004381_abnormal_hair_follicle1.52689675
63MP0001756_abnormal_urination1.49663747
64MP0003656_abnormal_erythrocyte_physiolo1.48615831
65MP0005058_abnormal_lysosome_morphology1.48230735
66MP0005164_abnormal_response_to1.46327627
67MP0002398_abnormal_bone_marrow1.44847959
68MP0001845_abnormal_inflammatory_respons1.44353395
69MP0005647_abnormal_sex_gland1.43915882
70MP0002166_altered_tumor_susceptibility1.43802653
71MP0000534_abnormal_ureter_morphology1.43178315
72MP0000716_abnormal_immune_system1.42252258
73MP0002295_abnormal_pulmonary_circulatio1.41628797
74MP0001533_abnormal_skeleton_physiology1.41061630
75MP0003123_paternal_imprinting1.40149792
76MP0002148_abnormal_hypersensitivity_rea1.39522864
77MP0000689_abnormal_spleen_morphology1.39147958
78MP0000627_abnormal_mammary_gland1.33855865
79MP0002722_abnormal_immune_system1.33550022
80MP0001346_abnormal_lacrimal_gland1.33063812
81MP0008469_abnormal_protein_level1.31791883
82MP0003828_pulmonary_edema1.31039348
83MP0000383_abnormal_hair_follicle1.29389295
84MP0001851_eye_inflammation1.23481717
85MP0001730_embryonic_growth_arrest1.21316658
86MP0001666_abnormal_nutrient_absorption1.21037417
87MP0010329_abnormal_lipoprotein_level1.20868923
88MP0003890_abnormal_embryonic-extraembry1.17588742
89MP0003941_abnormal_skin_development1.17060315
90MP0005367_renal/urinary_system_phenotyp1.16438161
91MP0000516_abnormal_urinary_system1.16438161
92MP0003690_abnormal_glial_cell1.15576793
93MP0005397_hematopoietic_system_phenotyp1.14823791
94MP0001545_abnormal_hematopoietic_system1.14823791
95MP0002429_abnormal_blood_cell1.14288824
96MP0000609_abnormal_liver_physiology1.12978941
97MP0003315_abnormal_perineum_morphology1.11427522
98MP0004885_abnormal_endolymph1.10218917
99MP0009764_decreased_sensitivity_to1.09683810
100MP0000703_abnormal_thymus_morphology1.08677905
101MP0005395_other_phenotype1.07516537
102MP0000858_altered_metastatic_potential1.06980052
103MP0004019_abnormal_vitamin_homeostasis1.06891848
104MP0003866_abnormal_defecation1.06789947
105MP0010155_abnormal_intestine_physiology1.04443242
106MP0005083_abnormal_biliary_tract1.04100828
107MP0008875_abnormal_xenobiotic_pharmacok1.03963801
108MP0003937_abnormal_limbs/digits/tail_de1.02494884
109MP0000350_abnormal_cell_proliferation1.02468784
110MP0000462_abnormal_digestive_system1.01671605
111MP0002796_impaired_skin_barrier1.01601091
112MP0009333_abnormal_splenocyte_physiolog1.01429384
113MP0003077_abnormal_cell_cycle1.00304031
114MP0000465_gastrointestinal_hemorrhage0.99376107
115MP0010094_abnormal_chromosome_stability0.98507416
116MP0008057_abnormal_DNA_replication0.98335701
117MP0002118_abnormal_lipid_homeostasis0.97975152
118MP0005076_abnormal_cell_differentiation0.97952843
119MP0005408_hypopigmentation0.96711274
120MP0001672_abnormal_embryogenesis/_devel0.96682986
121MP0005380_embryogenesis_phenotype0.96682986
122MP0001293_anophthalmia0.95509139
123MP0002160_abnormal_reproductive_system0.94538521
124MP0002138_abnormal_hepatobiliary_system0.94373307
125MP0002009_preneoplasia0.93269364
126MP0002168_other_aberrant_phenotype0.92288630
127MP0005319_abnormal_enzyme/_coenzyme0.92242856
128MP0000613_abnormal_salivary_gland0.91885671
129MP0009643_abnormal_urine_homeostasis0.91305236
130MP0003011_delayed_dark_adaptation0.90940523
131MP0000681_abnormal_thyroid_gland0.90458139
132MP0005075_abnormal_melanosome_morpholog0.90120072
133MP0001915_intracranial_hemorrhage0.89665270
134MP0000015_abnormal_ear_pigmentation0.87820442
135MP0001919_abnormal_reproductive_system0.87813256
136MP0001542_abnormal_bone_strength0.87536332
137MP0005376_homeostasis/metabolism_phenot0.87264345
138MP0001765_abnormal_ion_homeostasis0.87050485
139MP0005389_reproductive_system_phenotype0.86525932
140MP0002998_abnormal_bone_remodeling0.86394828
141MP0002006_tumorigenesis0.85067349
142MP0000647_abnormal_sebaceous_gland0.84833625
143MP0005187_abnormal_penis_morphology0.84534048
144MP0009840_abnormal_foam_cell0.84212636
145MP0009763_increased_sensitivity_to0.84169598
146MP0003984_embryonic_growth_retardation0.83421059
147MP0000579_abnormal_nail_morphology0.83296155
148MP0002233_abnormal_nose_morphology0.82700403
149MP0000371_diluted_coat_color0.82229085
150MP0001986_abnormal_taste_sensitivity0.81843901
151MP0004947_skin_inflammation0.81708737
152MP0003075_altered_response_to0.81130603
153MP0002136_abnormal_kidney_physiology0.80535552
154MP0005332_abnormal_amino_acid0.80058983
155MP0001485_abnormal_pinna_reflex0.79782010
156MP0002088_abnormal_embryonic_growth/wei0.79384514
157MP0004043_abnormal_pH_regulation0.78686736
158MP0003115_abnormal_respiratory_system0.78129766
159MP0002085_abnormal_embryonic_tissue0.77781831
160MP0003183_abnormal_peptide_metabolism0.77636420
161MP0009278_abnormal_bone_marrow0.77271565
162MP0001175_abnormal_lung_morphology0.77071762
163MP0005636_abnormal_mineral_homeostasis0.76930477
164MP0004484_altered_response_of0.76445087
165MP0000762_abnormal_tongue_morphology0.74469165
166MP0003566_abnormal_cell_adhesion0.73897183
167MP0002086_abnormal_extraembryonic_tissu0.73708372
168MP0000598_abnormal_liver_morphology0.72906579
169MP0003119_abnormal_digestive_system0.72819581
170MP0003221_abnormal_cardiomyocyte_apopto0.72626975
171MP0003191_abnormal_cellular_cholesterol0.72091235
172MP0002084_abnormal_developmental_patter0.71787492
173MP0002877_abnormal_melanocyte_morpholog0.71533986
174MP0003186_abnormal_redox_activity0.70882428
175MP0005220_abnormal_exocrine_pancreas0.70841940
176MP0003936_abnormal_reproductive_system0.69804741
177MP0001984_abnormal_olfaction0.69658257
178MP0001873_stomach_inflammation0.68981704
179MP0010352_gastrointestinal_tract_polyps0.68973247
180MP0003453_abnormal_keratinocyte_physiol0.68792602
181MP0001145_abnormal_male_reproductive0.66098435
182MP0002080_prenatal_lethality0.65981638

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)8.44442636
2Gout (HP:0001997)6.45110669
3Recurrent gram-negative bacterial infections (HP:0005420)5.03649779
4Recurrent abscess formation (HP:0002722)4.96563131
5Eczematoid dermatitis (HP:0000976)4.95113542
6Recurrent bacterial skin infections (HP:0005406)4.88018608
7Optic neuritis (HP:0100653)4.62150107
8Retrobulbar optic neuritis (HP:0100654)4.62150107
9Myositis (HP:0100614)4.55797128
10Orchitis (HP:0100796)4.46866929
11Shawl scrotum (HP:0000049)4.11958746
12Breast hypoplasia (HP:0003187)4.11496874
13Gastrointestinal infarctions (HP:0005244)4.10014098
14Tubulointerstitial fibrosis (HP:0005576)4.02150106
15Hyperactive renin-angiotensin system (HP:0000841)3.96583017
16Deep venous thrombosis (HP:0002625)3.96175588
17Tachypnea (HP:0002789)3.86822902
18Gingival bleeding (HP:0000225)3.79030952
19Renal salt wasting (HP:0000127)3.77986713
20Abnormality of cochlea (HP:0000375)3.73417429
21Recurrent skin infections (HP:0001581)3.58916688
22Abnormality of the labia minora (HP:0012880)3.56710776
23Hypokalemic alkalosis (HP:0001949)3.56165767
24Increased circulating renin level (HP:0000848)3.53900511
25Stomatitis (HP:0010280)3.50338194
26Chronic bronchitis (HP:0004469)3.41864676
27Keratoconjunctivitis sicca (HP:0001097)3.41079961
28Prolonged partial thromboplastin time (HP:0003645)3.39352014
29T lymphocytopenia (HP:0005403)3.37691012
30Recurrent fungal infections (HP:0002841)3.35090720
31Abnormality of T cell number (HP:0011839)3.32929744
32Respiratory distress (HP:0002098)3.27404572
33Hyperglycinuria (HP:0003108)3.22073970
34Hyperglycinemia (HP:0002154)3.20870575
35Keratoconjunctivitis (HP:0001096)3.15765666
36Ulnar bowing (HP:0003031)3.15552924
37Abnormal delayed hypersensitivity skin test (HP:0002963)3.14903201
38Recurrent cutaneous fungal infections (HP:0011370)3.14451761
39Chronic mucocutaneous candidiasis (HP:0002728)3.14451761
40Hypochromic microcytic anemia (HP:0004840)3.13898089
41Encephalitis (HP:0002383)3.12999256
42Metabolic alkalosis (HP:0200114)3.11653715
43Prolonged bleeding time (HP:0003010)3.11032232
44Hyperuricemia (HP:0002149)3.10290704
45Increased purine levels (HP:0004368)3.10290704
46Abnormality of the common coagulation pathway (HP:0010990)3.03317262
47Onycholysis (HP:0001806)3.01394898
48Tubulointerstitial nephritis (HP:0001970)3.00715607
49Stomach cancer (HP:0012126)2.99944865
50Pustule (HP:0200039)2.98952620
51Abnormality of the distal phalanges of the toes (HP:0010182)2.97305960
52Meningitis (HP:0001287)2.96128345
53Stenosis of the external auditory canal (HP:0000402)2.94375897
54Arterial thrombosis (HP:0004420)2.94173780
55Elevated erythrocyte sedimentation rate (HP:0003565)2.92828396
56Chronic obstructive pulmonary disease (HP:0006510)2.91371097
57Obstructive lung disease (HP:0006536)2.91371097
58Hypomagnesemia (HP:0002917)2.90491156
59Pulmonary embolism (HP:0002204)2.90466880
60Joint hemorrhage (HP:0005261)2.86416765
61Epistaxis (HP:0000421)2.85772910
62Hypochromic anemia (HP:0001931)2.83505521
63Spontaneous hematomas (HP:0007420)2.83435469
64Gingivitis (HP:0000230)2.82735587
65Sparse lateral eyebrow (HP:0005338)2.81809510
66Mediastinal lymphadenopathy (HP:0100721)2.77818402
67Vasculitis (HP:0002633)2.75521791
68Morphological abnormality of the inner ear (HP:0011390)2.73327161
69Anorexia (HP:0002039)2.70683421
70Peritonitis (HP:0002586)2.69487203
71Aplasia involving bones of the extremities (HP:0009825)2.67439422
72Aplasia involving bones of the upper limbs (HP:0009823)2.67439422
73Aplasia of the phalanges of the hand (HP:0009802)2.67439422
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.61203450
75Osteolytic defects of the hand bones (HP:0009699)2.61203450
76Thrombophlebitis (HP:0004418)2.60048993
77Gangrene (HP:0100758)2.59677682
78Abnormality of chloride homeostasis (HP:0011422)2.58358560
79Hemoptysis (HP:0002105)2.55989537
80Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.53946677
81Abnormality of the umbilical cord (HP:0010881)2.51963879
82Tubulointerstitial abnormality (HP:0001969)2.51007817
83Carpal bone hypoplasia (HP:0001498)2.49448536
84Hypoplastic nipples (HP:0002557)2.48659982
85Breast carcinoma (HP:0003002)2.48495126
86Prolonged neonatal jaundice (HP:0006579)2.48078569
87Abnormality of the 2nd finger (HP:0004100)2.47619810
88Chest pain (HP:0100749)2.45701016
89Short nail (HP:0001799)2.44288583
90Hypoplastic labia majora (HP:0000059)2.43782280
91Tetany (HP:0001281)2.43637749
92Abnormality of the phalanges of the 2nd finger (HP:0009541)2.42955269
93Menorrhagia (HP:0000132)2.41064757
94Abnormality of T cells (HP:0002843)2.40069298
95Urticaria (HP:0001025)2.39169124
96Aplasia/Hypoplasia of the ulna (HP:0006495)2.39121234
97Absent radius (HP:0003974)2.39027191
98Abnormality of glycine metabolism (HP:0010895)2.37680084
99Abnormality of serine family amino acid metabolism (HP:0010894)2.37680084
100Hypoplasia of the ulna (HP:0003022)2.36596576
101Acute hepatic failure (HP:0006554)2.36308205
102Facial shape deformation (HP:0011334)2.33734230
103Potter facies (HP:0002009)2.33734230
104Amyloidosis (HP:0011034)2.33170161
105Abnormal platelet volume (HP:0011876)2.32977280
106Abnormality of the proximal phalanges of the hand (HP:0009834)2.30374150
107Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.29671573
108Short 1st metacarpal (HP:0010034)2.29671573
109Pulmonary infiltrates (HP:0002113)2.29258498
110Impulsivity (HP:0100710)2.26970266
111Episodic fever (HP:0001954)2.26939939
112Hypobetalipoproteinemia (HP:0003563)2.25489296
113Congenital, generalized hypertrichosis (HP:0004540)2.25205905
114Abnormality of the middle phalanges of the toes (HP:0010183)2.23535486
115Subcapsular cataract (HP:0000523)2.23050280
116Leukocytosis (HP:0001974)2.20999978
117Absent hand (HP:0004050)2.19675657
118Abnormality of purine metabolism (HP:0004352)2.19618839
119Broad distal phalanx of finger (HP:0009836)2.19056326
120Aplasia involving forearm bones (HP:0009822)2.19043359
121Absent forearm bone (HP:0003953)2.19043359
122Glucose intolerance (HP:0000833)2.18511151
123Bowing of the arm (HP:0006488)2.15792188
124Bowed forearm bones (HP:0003956)2.15792188
125Abnormality of the labia majora (HP:0012881)2.15028198
126Aplasia/Hypoplasia of the hallux (HP:0008362)2.14964933
127Papillary thyroid carcinoma (HP:0002895)2.14181351
128Polyuria (HP:0000103)2.11136019
129Aplasia/Hypoplasia of the patella (HP:0006498)2.09537760
130Abnormality of the fingertips (HP:0001211)2.08906639
131Long toe (HP:0010511)2.08499682
132Short humerus (HP:0005792)2.07995654
133Systemic lupus erythematosus (HP:0002725)2.07110296
134Ureteral duplication (HP:0000073)2.06973220
135Purpura (HP:0000979)2.06900576
136Osteomalacia (HP:0002749)2.06588155
137Aplasia/hypoplasia of the humerus (HP:0006507)2.06304111
138Subacute progressive viral hepatitis (HP:0006572)2.04492459
139Hypoplastic scapulae (HP:0000882)2.04409737
140Aplasia/Hypoplasia of the scapulae (HP:0006713)2.04409737
141Abnormality of the pleura (HP:0002103)2.03585494
142Recurrent viral infections (HP:0004429)2.02298194
143Abnormality of the peritoneum (HP:0002585)2.02186384
144Abnormal urine output (HP:0012590)2.01803414
145Short hallux (HP:0010109)2.01565434
146Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00998276
147Male infertility (HP:0003251)2.00237465
148Stillbirth (HP:0003826)2.00032412
149Split foot (HP:0001839)1.99926471
150Abnormality of the 1st metacarpal (HP:0010009)1.99881657
151Lip pit (HP:0100267)1.98458473
152Joint swelling (HP:0001386)1.97402346
153Anal stenosis (HP:0002025)1.97068880
154Breast aplasia (HP:0100783)1.95865172
155Osteomyelitis (HP:0002754)1.94947362
156Myocardial infarction (HP:0001658)1.94528519
157Aplasia of the musculature (HP:0100854)1.92236023
158Facial hemangioma (HP:0000329)1.92218584
159Short clavicles (HP:0000894)1.92133754
160Hypotension (HP:0002615)1.91099013
161Hematochezia (HP:0002573)1.91047631
162Patellar aplasia (HP:0006443)1.90269867
163Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90098671
164Recurrent sinusitis (HP:0011108)1.90009454
165Abnormality of renal excretion (HP:0011036)1.89776697
166Abnormality of T cell physiology (HP:0011840)1.89193691
167Hyperaldosteronism (HP:0000859)1.88292398
168Abnormality of magnesium homeostasis (HP:0004921)1.87605036
169Aplasia/Hypoplasia of the breasts (HP:0010311)1.87538419
170Increased mean platelet volume (HP:0011877)1.87001866
171Abnormality of the labia (HP:0000058)1.86591263
172Entropion (HP:0000621)1.86311693
173Glomerulonephritis (HP:0000099)1.86095838
174Spontaneous abortion (HP:0005268)1.85644328
175Acanthocytosis (HP:0001927)1.84981547
176Labial hypoplasia (HP:0000066)1.84549760
177Aplasia/Hypoplasia of the earlobes (HP:0009906)1.83736531
178Toxemia of pregnancy (HP:0100603)1.83279952
179Glomerulopathy (HP:0100820)1.82732016
180Hypoplastic female external genitalia (HP:0012815)1.81493736
181Abnormality of renin-angiotensin system (HP:0000847)1.81478343
182Biliary tract neoplasm (HP:0100574)1.80851789
183Ankle contracture (HP:0006466)1.80636327
184Abnormality of macrophages (HP:0004311)1.79472541
185Autoimmune hemolytic anemia (HP:0001890)1.79238174
186Complement deficiency (HP:0004431)1.78862491
187Death in infancy (HP:0001522)1.78841628
188Rickets (HP:0002748)1.78137767
189Eosinophilia (HP:0001880)1.76642209
190Microcytic anemia (HP:0001935)1.75946673
191Viral hepatitis (HP:0006562)1.75303808
192Fibular aplasia (HP:0002990)1.72374504
193Abnormality of the axillary hair (HP:0100134)1.72211324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.97789668
2EPHA24.15671302
3RIPK44.11448309
4MST43.64024736
5BUB13.50180073
6STK243.03276494
7BLK2.88914477
8STK38L2.82539545
9TXK2.81628495
10FRK2.67114838
11LATS12.58691933
12WEE12.55879918
13CSK2.55381176
14TYK22.51693390
15IRAK42.34114784
16STK392.28570926
17PDK22.23237072
18OXSR12.22290885
19PLK42.21489270
20NEK12.15752797
21GRK62.15061361
22FGFR22.13179241
23MAP3K32.12018988
24MAP4K12.03639537
25NEK21.99723587
26FGFR31.89239949
27FGR1.85643399
28FES1.84248523
29YES11.83092427
30FGFR41.76508412
31STK101.75081360
32TAOK31.71067064
33BTK1.66191897
34MAP3K21.60224673
35LRRK21.60191171
36ERBB31.58992115
37TEC1.58417549
38PIK3CG1.57583066
39JAK31.51425130
40SYK1.51246969
41MAP3K141.50639237
42TSSK61.49775200
43STK31.47319736
44TTK1.42508317
45JAK21.42323593
46JAK11.40948726
47LATS21.36285621
48PINK11.35003800
49BRSK21.33202938
50PLK31.32963067
51ITK1.32885145
52ZAK1.28332676
53LYN1.27137679
54HCK1.26987040
55RPS6KB21.24255063
56WNK11.22874692
57IKBKE1.22704169
58MATK1.20926042
59MAP3K91.20085045
60NLK1.14995002
61IRAK11.11383994
62PDK31.10829462
63PDK41.10829462
64PRKCI1.06372085
65LCK1.04436522
66MYLK1.02922846
67CSF1R0.99636265
68PLK10.99601603
69TGFBR20.97926471
70CDK120.96364734
71MAP3K60.95436081
72CAMK1D0.95093538
73MARK30.91659027
74SGK2230.90007366
75SGK4940.90007366
76EIF2AK30.87257307
77LMTK20.85243818
78PAK40.85015965
79PDK10.84984557
80SIK30.82863597
81KSR20.82495559
82AURKA0.82300630
83MAPKAPK30.81150288
84PNCK0.79378988
85AURKB0.78680049
86GRK10.77815245
87RIPK10.77213874
88FER0.76713305
89BRD40.76408893
90MAP3K70.76191001
91PRKAA20.74671045
92EEF2K0.74275286
93EPHA30.71860770
94CAMK1G0.70242403
95MAP3K50.70125080
96MAP3K10.69895276
97PTK2B0.69089516
98MELK0.68806658
99PRKCQ0.68387448
100KIT0.67409840
101MAP3K80.66981067
102CHEK20.63977269
103STK380.63126466
104PIM10.62208571
105DYRK30.62007015
106ZAP700.61780121
107DAPK20.61016916
108SRPK10.59374723
109PIK3CA0.58292504
110STK110.57897605
111ARAF0.57613921
112MAP2K20.56669121
113MAP2K40.56047018
114BRSK10.55071385
115NUAK10.52900456
116ERBB20.52280109
117PRPF4B0.52237679
118SGK10.51827484
119TNK20.48964797
120TRPM70.48575796
121PDGFRB0.48389361
122FYN0.47780121
123TESK10.47580203
124MKNK20.47460600
125MARK20.47316898
126TAOK10.45738525
127MAP2K60.45159156
128ACVR1B0.44870065
129BCKDK0.44153206
130CSNK1G10.43846555
131CSNK1G20.43707540
132IRAK20.43147389
133RAF10.42901487
134IKBKB0.42860210
135WNK30.42242266
136CSNK1A1L0.40932160
137CDK60.40283218
138GSK3A0.40179405
139CAMK40.40107137
140BRAF0.39535899
141RET0.38417989
142TBK10.37276672
143CSNK1G30.36893158
144WNK40.36554938
145IGF1R0.36030317
146EGFR0.35992991
147PTK20.35866344
148STK40.35633729
149PDPK10.35322718
150PRKCZ0.34233714
151EPHB10.33677276
152PTK60.32888884
153DYRK1B0.31778077
154NEK60.31324588
155BMPR20.30614472
156TIE10.28809771
157SGK30.27555055
158ILK0.27086676
159RPS6KA40.26101842
160SGK20.25957968
161CDK70.25863889
162MAP3K120.25519126
163ALK0.24989924
164CHEK10.23365332
165EIF2AK10.23135630
166MAPK150.22990705
167MST1R0.21700448
168TTN0.21093386
169AKT20.20137281
170PRKAA10.20088934
171BCR0.19198066
172ERN10.19121591
173MAP2K30.19072795

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.87128048
2Staphylococcus aureus infection_Homo sapiens_hsa051503.47409244
3Complement and coagulation cascades_Homo sapiens_hsa046102.93901522
4Mineral absorption_Homo sapiens_hsa049782.91222785
5Leishmaniasis_Homo sapiens_hsa051402.55654573
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43456737
7RNA polymerase_Homo sapiens_hsa030202.32564237
8Osteoclast differentiation_Homo sapiens_hsa043802.27926962
9Sulfur metabolism_Homo sapiens_hsa009202.23925677
10Collecting duct acid secretion_Homo sapiens_hsa049662.21552395
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16803647
12Regulation of autophagy_Homo sapiens_hsa041402.10459406
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08529549
14Vitamin digestion and absorption_Homo sapiens_hsa049772.07192913
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.04476286
16Tight junction_Homo sapiens_hsa045302.03931661
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96755929
18Glutathione metabolism_Homo sapiens_hsa004801.94506893
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.87052336
20Tuberculosis_Homo sapiens_hsa051521.86790608
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81204861
22Graft-versus-host disease_Homo sapiens_hsa053321.77046843
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.75574010
24Lysosome_Homo sapiens_hsa041421.75403657
25B cell receptor signaling pathway_Homo sapiens_hsa046621.70844210
26RNA transport_Homo sapiens_hsa030131.70705461
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.68182964
28Renin-angiotensin system_Homo sapiens_hsa046141.63111130
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60557724
30Folate biosynthesis_Homo sapiens_hsa007901.60312446
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58450153
32Adherens junction_Homo sapiens_hsa045201.56719095
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.54568700
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.54464744
35Measles_Homo sapiens_hsa051621.53631003
36Legionellosis_Homo sapiens_hsa051341.51232316
37Cell cycle_Homo sapiens_hsa041101.51156263
38Hippo signaling pathway_Homo sapiens_hsa043901.47502851
39Hematopoietic cell lineage_Homo sapiens_hsa046401.46462238
40Vibrio cholerae infection_Homo sapiens_hsa051101.45681015
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44994279
42Fatty acid degradation_Homo sapiens_hsa000711.43875193
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42407943
44Malaria_Homo sapiens_hsa051441.42105043
45Pentose phosphate pathway_Homo sapiens_hsa000301.38817470
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37117544
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36134889
48T cell receptor signaling pathway_Homo sapiens_hsa046601.34201055
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33279509
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.32866371
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31866618
52Non-small cell lung cancer_Homo sapiens_hsa052231.31635609
53Sphingolipid metabolism_Homo sapiens_hsa006001.30641377
54Sulfur relay system_Homo sapiens_hsa041221.29902455
55Primary immunodeficiency_Homo sapiens_hsa053401.29733886
56Chemokine signaling pathway_Homo sapiens_hsa040621.25408584
57Inositol phosphate metabolism_Homo sapiens_hsa005621.24059687
58Histidine metabolism_Homo sapiens_hsa003401.20487126
59Antigen processing and presentation_Homo sapiens_hsa046121.17297019
60Allograft rejection_Homo sapiens_hsa053301.15888094
61Autoimmune thyroid disease_Homo sapiens_hsa053201.14658579
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13992556
63PPAR signaling pathway_Homo sapiens_hsa033201.12721383
64Influenza A_Homo sapiens_hsa051641.12173860
65Platelet activation_Homo sapiens_hsa046111.10533250
66Starch and sucrose metabolism_Homo sapiens_hsa005001.09503364
67p53 signaling pathway_Homo sapiens_hsa041151.08125864
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07380108
69Acute myeloid leukemia_Homo sapiens_hsa052211.07272267
70NF-kappa B signaling pathway_Homo sapiens_hsa040641.06978797
71Small cell lung cancer_Homo sapiens_hsa052221.06061298
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05267837
73Drug metabolism - other enzymes_Homo sapiens_hsa009831.03744131
74Oocyte meiosis_Homo sapiens_hsa041140.99701655
75Fructose and mannose metabolism_Homo sapiens_hsa000510.98672380
76FoxO signaling pathway_Homo sapiens_hsa040680.97813083
77Bladder cancer_Homo sapiens_hsa052190.96633406
78Prostate cancer_Homo sapiens_hsa052150.96031068
79Circadian rhythm_Homo sapiens_hsa047100.95281610
80Other glycan degradation_Homo sapiens_hsa005110.93142902
81Pancreatic cancer_Homo sapiens_hsa052120.93123481
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92625480
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92388481
84Phagosome_Homo sapiens_hsa041450.91990994
85Pertussis_Homo sapiens_hsa051330.91039653
86Herpes simplex infection_Homo sapiens_hsa051680.90864095
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90487435
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90426480
89Toxoplasmosis_Homo sapiens_hsa051450.90201038
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87658162
91Fatty acid metabolism_Homo sapiens_hsa012120.87651992
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84778004
93Fatty acid biosynthesis_Homo sapiens_hsa000610.84069026
94Endometrial cancer_Homo sapiens_hsa052130.83724996
95African trypanosomiasis_Homo sapiens_hsa051430.81912166
96Hepatitis B_Homo sapiens_hsa051610.81537842
97TGF-beta signaling pathway_Homo sapiens_hsa043500.80739247
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80288953
99TNF signaling pathway_Homo sapiens_hsa046680.79631200
100Purine metabolism_Homo sapiens_hsa002300.78653832
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77513009
102Steroid biosynthesis_Homo sapiens_hsa001000.76704204
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.75739287
104Hepatitis C_Homo sapiens_hsa051600.75400507
105Basal transcription factors_Homo sapiens_hsa030220.74022986
106Pyrimidine metabolism_Homo sapiens_hsa002400.74019497
107Type I diabetes mellitus_Homo sapiens_hsa049400.73102396
108Rheumatoid arthritis_Homo sapiens_hsa053230.73065168
109Choline metabolism in cancer_Homo sapiens_hsa052310.72262000
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71858981
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71460626
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.70003158
113Selenocompound metabolism_Homo sapiens_hsa004500.67138805
114Chemical carcinogenesis_Homo sapiens_hsa052040.66806801
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66789846
116Glycerolipid metabolism_Homo sapiens_hsa005610.66722330
117Retinol metabolism_Homo sapiens_hsa008300.66034611
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65197322
119mTOR signaling pathway_Homo sapiens_hsa041500.64724513
120Insulin resistance_Homo sapiens_hsa049310.64168111
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63401247
122Thyroid cancer_Homo sapiens_hsa052160.63101282
123Butanoate metabolism_Homo sapiens_hsa006500.63048881
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62503664
125Prolactin signaling pathway_Homo sapiens_hsa049170.62417415
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61542400
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.59960411
128Nitrogen metabolism_Homo sapiens_hsa009100.59878552
129Dorso-ventral axis formation_Homo sapiens_hsa043200.59350715
130ECM-receptor interaction_Homo sapiens_hsa045120.56366980
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55995923
132Caffeine metabolism_Homo sapiens_hsa002320.54557435
133Peroxisome_Homo sapiens_hsa041460.54440125
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54402967
135Proteasome_Homo sapiens_hsa030500.54222454
136Apoptosis_Homo sapiens_hsa042100.51760033
137Asthma_Homo sapiens_hsa053100.51283883
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.50953639
139HIF-1 signaling pathway_Homo sapiens_hsa040660.50376541
140Chronic myeloid leukemia_Homo sapiens_hsa052200.50362458
141Propanoate metabolism_Homo sapiens_hsa006400.49673293
142Bile secretion_Homo sapiens_hsa049760.49653308
143Thyroid hormone synthesis_Homo sapiens_hsa049180.49627894
144Amoebiasis_Homo sapiens_hsa051460.48220470
145Tryptophan metabolism_Homo sapiens_hsa003800.47992741
146Viral myocarditis_Homo sapiens_hsa054160.47966092
147Pathways in cancer_Homo sapiens_hsa052000.47841321
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47172623
149Fat digestion and absorption_Homo sapiens_hsa049750.46960995
150Arachidonic acid metabolism_Homo sapiens_hsa005900.45415863
151Epstein-Barr virus infection_Homo sapiens_hsa051690.44967978
152Gastric acid secretion_Homo sapiens_hsa049710.44683411
153ABC transporters_Homo sapiens_hsa020100.44080215
154Melanoma_Homo sapiens_hsa052180.42263731
155MicroRNAs in cancer_Homo sapiens_hsa052060.42166871
156Olfactory transduction_Homo sapiens_hsa047400.40203934
157Fanconi anemia pathway_Homo sapiens_hsa034600.39433604
158Arginine and proline metabolism_Homo sapiens_hsa003300.38088279
159Renal cell carcinoma_Homo sapiens_hsa052110.36966437
160Ether lipid metabolism_Homo sapiens_hsa005650.35925862
161beta-Alanine metabolism_Homo sapiens_hsa004100.35456910
162Endocytosis_Homo sapiens_hsa041440.34853048
163AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33510836
164Biosynthesis of amino acids_Homo sapiens_hsa012300.32580030
165N-Glycan biosynthesis_Homo sapiens_hsa005100.29661001
166Viral carcinogenesis_Homo sapiens_hsa052030.28573165
167Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28349276
168Focal adhesion_Homo sapiens_hsa045100.28284357
169Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27735407
170Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27459081

Most similar genes based on co-expression Upload to Enrichr

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