SLCO6A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)7.92307563
2sperm motility (GO:0030317)7.55818598
3male meiosis I (GO:0007141)7.39594420
4acrosome reaction (GO:0007340)7.38442156
5male meiosis (GO:0007140)7.22231234
6chromosome organization involved in meiosis (GO:0070192)7.10371613
7piRNA metabolic process (GO:0034587)7.03566789
8fusion of sperm to egg plasma membrane (GO:0007342)6.82911194
9meiosis I (GO:0007127)6.48767672
10synaptonemal complex assembly (GO:0007130)6.28473623
11spermatid development (GO:0007286)6.11282965
12microtubule depolymerization (GO:0007019)6.04038487
13DNA packaging (GO:0006323)5.94248458
14DNA methylation involved in gamete generation (GO:0043046)5.91993646
15sperm-egg recognition (GO:0035036)5.90838801
16sperm capacitation (GO:0048240)5.73233015
17binding of sperm to zona pellucida (GO:0007339)5.70853756
18meiotic nuclear division (GO:0007126)5.65357180
19synaptonemal complex organization (GO:0070193)5.61943991
20chromosome condensation (GO:0030261)5.61212849
21rRNA methylation (GO:0031167)5.36976373
22single strand break repair (GO:0000012)5.33062748
23microtubule polymerization or depolymerization (GO:0031109)5.28791902
24multicellular organism reproduction (GO:0032504)5.28648183
25protein targeting to Golgi (GO:0000042)5.12474610
26plasma membrane fusion (GO:0045026)5.10935180
27regulation of meiosis I (GO:0060631)5.08018512
28establishment of protein localization to Golgi (GO:0072600)4.93100539
29spermatogenesis (GO:0007283)4.87442401
30male gamete generation (GO:0048232)4.86970842
31meiotic cell cycle process (GO:1903046)4.86146941
32centriole replication (GO:0007099)4.81687456
33cell-cell recognition (GO:0009988)4.80640545
34axonemal dynein complex assembly (GO:0070286)4.68867231
35retrograde transport, vesicle recycling within Golgi (GO:0000301)4.64372912
36gamete generation (GO:0007276)4.62969360
37response to pheromone (GO:0019236)4.61495579
38reproduction (GO:0000003)4.50702211
39regulation of centriole replication (GO:0046599)4.49306884
40rRNA modification (GO:0000154)4.36849743
41cilium or flagellum-dependent cell motility (GO:0001539)4.32459805
42DNA synthesis involved in DNA repair (GO:0000731)4.28285678
43protein polyglutamylation (GO:0018095)4.27630259
44spermatid nucleus differentiation (GO:0007289)4.27139132
45epithelial cilium movement (GO:0003351)4.26631449
46sister chromatid cohesion (GO:0007062)4.13169244
47genitalia morphogenesis (GO:0035112)4.09899051
48resolution of meiotic recombination intermediates (GO:0000712)4.08801248
49centriole assembly (GO:0098534)4.02604110
50histone exchange (GO:0043486)4.01450057
51fertilization (GO:0009566)4.00173160
52cellular ketone body metabolic process (GO:0046950)3.94737578
53single fertilization (GO:0007338)3.81100605
54meiotic chromosome segregation (GO:0045132)3.79538583
55regulation of cilium movement (GO:0003352)3.78406405
56germ cell development (GO:0007281)3.76233316
57protein localization to Golgi apparatus (GO:0034067)3.73486023
58positive regulation of meiosis (GO:0045836)3.70869590
59negative regulation of inclusion body assembly (GO:0090084)3.65432170
60multicellular organismal reproductive process (GO:0048609)3.64609128
61cellular process involved in reproduction in multicellular organism (GO:0022412)3.63485995
62calcium ion-dependent exocytosis (GO:0017156)3.59640285
63positive regulation of meiotic cell cycle (GO:0051446)3.49283976
64cilium movement (GO:0003341)3.47170623
65ketone body metabolic process (GO:1902224)3.45831284
66coenzyme catabolic process (GO:0009109)3.45530992
67phosphatidylethanolamine biosynthetic process (GO:0006646)3.44842046
68somite rostral/caudal axis specification (GO:0032525)3.35836500
69reciprocal meiotic recombination (GO:0007131)3.25366028
70reciprocal DNA recombination (GO:0035825)3.25366028
71phosphatidylethanolamine metabolic process (GO:0046337)3.14705837
72histone H3-K9 demethylation (GO:0033169)3.13365229
73seminiferous tubule development (GO:0072520)3.09584578
74sexual reproduction (GO:0019953)3.07696660
75regulation of mesoderm development (GO:2000380)3.04660666
76regulation of double-strand break repair via homologous recombination (GO:0010569)3.01642213
77motile cilium assembly (GO:0044458)3.00133599
78cell wall macromolecule catabolic process (GO:0016998)2.98613066
79nucleus organization (GO:0006997)2.98327888
80RNA destabilization (GO:0050779)2.95009778
81intraciliary transport (GO:0042073)2.94185494
82cell wall macromolecule metabolic process (GO:0044036)2.87855112
83regulation of microtubule-based movement (GO:0060632)2.85482964
84detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.81998159
85mitotic sister chromatid cohesion (GO:0007064)2.79265360
86embryonic foregut morphogenesis (GO:0048617)2.78345137
87polyamine biosynthetic process (GO:0006596)2.76731539
88regulation of transcription involved in cell fate commitment (GO:0060850)2.75911311
89negative regulation of gene silencing (GO:0060969)2.75882527
90organic cation transport (GO:0015695)2.73657707
91proteasome assembly (GO:0043248)2.72484860
92microtubule severing (GO:0051013)2.72383131
93female gamete generation (GO:0007292)2.71855750
94cerebral cortex neuron differentiation (GO:0021895)2.71284546
95nuclear pore complex assembly (GO:0051292)2.66049157
96reproductive system development (GO:0061458)2.62782306
97gene silencing by RNA (GO:0031047)2.57821187
98regulation of centrosome duplication (GO:0010824)2.56549697
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.54892270
100positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.54125745

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.87810545
2FUS_26573619_Chip-Seq_HEK293_Human3.66595711
3TAF15_26573619_Chip-Seq_HEK293_Human2.85287061
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.75034210
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.74450547
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70700550
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.70700550
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.56653535
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53619094
10EZH2_22144423_ChIP-Seq_EOC_Human2.43799681
11VDR_22108803_ChIP-Seq_LS180_Human2.42296597
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23535312
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20268400
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20150522
15P300_19829295_ChIP-Seq_ESCs_Human2.17243238
16ER_23166858_ChIP-Seq_MCF-7_Human2.14422442
17ZNF274_21170338_ChIP-Seq_K562_Hela2.10009116
18* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.01695175
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.98718317
20SMAD3_21741376_ChIP-Seq_EPCs_Human1.97482414
21SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.96190631
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.94007386
23CBP_20019798_ChIP-Seq_JUKART_Human1.94007386
24IGF1R_20145208_ChIP-Seq_DFB_Human1.82701217
25EWS_26573619_Chip-Seq_HEK293_Human1.82395123
26AUTS2_25519132_ChIP-Seq_293T-REX_Human1.79653731
27AR_25329375_ChIP-Seq_VCAP_Human1.79192757
28SMAD4_21741376_ChIP-Seq_EPCs_Human1.76116435
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72067792
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.68584586
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64254890
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.59204701
33KLF5_20875108_ChIP-Seq_MESCs_Mouse1.57327290
34AR_21572438_ChIP-Seq_LNCaP_Human1.49933698
35* SOX2_19829295_ChIP-Seq_ESCs_Human1.47070416
36* NANOG_19829295_ChIP-Seq_ESCs_Human1.47070416
37BCAT_22108803_ChIP-Seq_LS180_Human1.43714674
38SMAD4_21799915_ChIP-Seq_A2780_Human1.42743579
39* RUNX2_22187159_ChIP-Seq_PCA_Human1.38413280
40RNF2_27304074_Chip-Seq_NSC_Mouse1.37593069
41* STAT3_23295773_ChIP-Seq_U87_Human1.35683786
42ERG_20517297_ChIP-Seq_VCAP_Human1.35284554
43NANOG_20526341_ChIP-Seq_ESCs_Human1.34189432
44ETV1_20927104_ChIP-Seq_GIST48_Human1.34142856
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.33936109
46FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33226300
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32346205
48SMAD4_21741376_ChIP-Seq_HESCs_Human1.30620089
49RBPJ_21746931_ChIP-Seq_IB4_Human1.30417435
50CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30032632
51TCF4_22108803_ChIP-Seq_LS180_Human1.28977989
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28958462
53PHF8_20622853_ChIP-Seq_HELA_Human1.28793668
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28316276
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27955133
56TP53_18474530_ChIP-ChIP_U2OS_Human1.27630837
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27298418
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.27211891
59CBX2_22325352_ChIP-Seq_293T-Rex_Human1.25893824
60CDX2_22108803_ChIP-Seq_LS180_Human1.24252542
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.23669572
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.23335954
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23335954
64TCF4_23295773_ChIP-Seq_U87_Human1.22231787
65NFYB_21822215_ChIP-Seq_K562_Human1.22011277
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21578820
67SMAD3_21741376_ChIP-Seq_ESCs_Human1.18784811
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18752344
69MYC_19829295_ChIP-Seq_ESCs_Human1.17499627
70ERA_21632823_ChIP-Seq_H3396_Human1.17355165
71TBL1_22424771_ChIP-Seq_293T_Human1.16820173
72PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.16650297
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.16470154
74FOXH1_21741376_ChIP-Seq_EPCs_Human1.16044598
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11856564
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11371092
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.11086448
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.10593458
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10583660
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10029709
81NFYA_21822215_ChIP-Seq_K562_Human1.09640592
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09436311
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08413980
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.08403344
85GATA3_26560356_Chip-Seq_TH1_Human1.07759005
86HOXB7_26014856_ChIP-Seq_BT474_Human1.06542089
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06367081
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.06042315
89WDR5_24793694_ChIP-Seq_LNCAP_Human1.05635415
90MYC_18940864_ChIP-ChIP_HL60_Human1.04761957
91CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04363649
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03708710
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03038626
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02979975
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.02741815
96* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02637412
97ELK1_19687146_ChIP-ChIP_HELA_Human1.02144248
98GATA6_21074721_ChIP-Seq_CACO-2_Human1.02137305
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00849405
100TP53_22573176_ChIP-Seq_HFKS_Human0.99568425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.94999994
2MP0008877_abnormal_DNA_methylation4.12906331
3MP0003698_abnormal_male_reproductive3.75785109
4MP0001929_abnormal_gametogenesis3.73977640
5MP0002210_abnormal_sex_determination2.87783518
6MP0009379_abnormal_foot_pigmentation2.73027137
7MP0010030_abnormal_orbit_morphology2.57221881
8MP0005377_hearing/vestibular/ear_phenot2.47159572
9MP0003878_abnormal_ear_physiology2.47159572
10MP0001145_abnormal_male_reproductive2.33246729
11MP0003119_abnormal_digestive_system2.31258789
12MP0008058_abnormal_DNA_repair2.29509692
13MP0008789_abnormal_olfactory_epithelium2.28785000
14MP0006054_spinal_hemorrhage2.28123544
15MP0009053_abnormal_anal_canal2.26568961
16MP0000653_abnormal_sex_gland2.21413416
17MP0003718_maternal_effect2.19488184
18MP0002161_abnormal_fertility/fecundity2.09929236
19MP0006292_abnormal_olfactory_placode2.09368182
20MP0002282_abnormal_trachea_morphology2.00624987
21MP0003136_yellow_coat_color1.94490557
22MP0003880_abnormal_central_pattern1.86660318
23MP0005394_taste/olfaction_phenotype1.85891509
24MP0005499_abnormal_olfactory_system1.85891509
25MP0000372_irregular_coat_pigmentation1.84170986
26MP0002234_abnormal_pharynx_morphology1.78588678
27MP0003890_abnormal_embryonic-extraembry1.72922723
28MP0009697_abnormal_copulation1.72332541
29MP0000579_abnormal_nail_morphology1.68596700
30MP0008995_early_reproductive_senescence1.66696747
31MP0005423_abnormal_somatic_nervous1.65116429
32MP0000566_synostosis1.58798749
33MP0001485_abnormal_pinna_reflex1.57864515
34MP0004957_abnormal_blastocyst_morpholog1.53876351
35MP0008004_abnormal_stomach_pH1.51361197
36MP0000383_abnormal_hair_follicle1.46791659
37MP0003937_abnormal_limbs/digits/tail_de1.44673540
38MP0005551_abnormal_eye_electrophysiolog1.43518929
39MP0002233_abnormal_nose_morphology1.43338206
40MP0003385_abnormal_body_wall1.42434189
41MP0002160_abnormal_reproductive_system1.37305952
42MP0003011_delayed_dark_adaptation1.31369860
43MP0005084_abnormal_gallbladder_morpholo1.29153210
44MP0002254_reproductive_system_inflammat1.26566484
45MP0001293_anophthalmia1.25998069
46MP0010678_abnormal_skin_adnexa1.19793149
47MP0005253_abnormal_eye_physiology1.17747091
48MP0002132_abnormal_respiratory_system1.17435775
49MP0001879_abnormal_lymphatic_vessel1.15602641
50MP0001119_abnormal_female_reproductive1.08118539
51MP0009250_abnormal_appendicular_skeleto1.06828363
52MP0001286_abnormal_eye_development1.05473590
53MP0002249_abnormal_larynx_morphology1.05179413
54MP0001984_abnormal_olfaction1.01511962
55MP0002736_abnormal_nociception_after0.99510139
56MP0000049_abnormal_middle_ear0.98902550
57MP0002102_abnormal_ear_morphology0.96671410
58MP0003646_muscle_fatigue0.91519407
59MP0003077_abnormal_cell_cycle0.88558718
60MP0002109_abnormal_limb_morphology0.87799505
61MP0003936_abnormal_reproductive_system0.87527337
62MP0003115_abnormal_respiratory_system0.87326375
63MP0005167_abnormal_blood-brain_barrier0.86986421
64MP0001486_abnormal_startle_reflex0.86914202
65MP0000462_abnormal_digestive_system0.86791629
66MP0006072_abnormal_retinal_apoptosis0.86755891
67MP0003699_abnormal_female_reproductive0.86717676
68MP0001348_abnormal_lacrimal_gland0.86279546
69MP0000026_abnormal_inner_ear0.85716851
70MP0001666_abnormal_nutrient_absorption0.85551430
71MP0001346_abnormal_lacrimal_gland0.84992115
72MP0002084_abnormal_developmental_patter0.84629822
73MP0005389_reproductive_system_phenotype0.83397279
74MP0001529_abnormal_vocalization0.82788230
75MP0005391_vision/eye_phenotype0.82712450
76MP0002938_white_spotting0.82698531
77MP0003935_abnormal_craniofacial_develop0.79891402
78MP0008961_abnormal_basal_metabolism0.79594356
79MP0000762_abnormal_tongue_morphology0.79199172
80MP0001963_abnormal_hearing_physiology0.79103235
81MP0001968_abnormal_touch/_nociception0.78978386
82MP0002085_abnormal_embryonic_tissue0.78328761
83MP0005248_abnormal_Harderian_gland0.77363847
84MP0005670_abnormal_white_adipose0.76045408
85MP0002928_abnormal_bile_duct0.73812443
86MP0002697_abnormal_eye_size0.72787708
87MP0004133_heterotaxia0.70696773
88MP0003938_abnormal_ear_development0.69562981
89MP0010094_abnormal_chromosome_stability0.67411639
90MP0003693_abnormal_embryo_hatching0.66271247
91MP0003941_abnormal_skin_development0.65944511
92MP0000955_abnormal_spinal_cord0.64260010
93MP0003755_abnormal_palate_morphology0.64092386
94MP0000631_abnormal_neuroendocrine_gland0.60816391
95MP0003861_abnormal_nervous_system0.60254678
96MP0005379_endocrine/exocrine_gland_phen0.58352612
97MP0001299_abnormal_eye_distance/0.58338608
98MP0000427_abnormal_hair_cycle0.57718293
99MP0000432_abnormal_head_morphology0.56756638
100MP0000647_abnormal_sebaceous_gland0.56199370

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.43317563
2Absent/shortened dynein arms (HP:0200106)4.43317563
3Tubulointerstitial nephritis (HP:0001970)4.38854656
4Severe visual impairment (HP:0001141)4.06842486
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.87475344
6Abnormal respiratory motile cilium physiology (HP:0012261)3.67539994
7Gonadotropin excess (HP:0000837)3.60012939
8Nephronophthisis (HP:0000090)3.53717224
9Abnormal ciliary motility (HP:0012262)3.33975845
10Abnormal respiratory epithelium morphology (HP:0012253)3.29503667
11Abnormal respiratory motile cilium morphology (HP:0005938)3.29503667
12Azoospermia (HP:0000027)3.21297939
13Abnormality of the renal medulla (HP:0100957)3.19968569
14Attenuation of retinal blood vessels (HP:0007843)3.09400820
15Bony spicule pigmentary retinopathy (HP:0007737)3.08552138
16Volvulus (HP:0002580)3.05712583
17Hyperkalemia (HP:0002153)3.02062973
18Rhinitis (HP:0012384)3.01191745
19Abnormal spermatogenesis (HP:0008669)2.95036816
20Chronic hepatic failure (HP:0100626)2.89766738
21Cerebellar dysplasia (HP:0007033)2.80939319
22Optic nerve hypoplasia (HP:0000609)2.76660940
23Bell-shaped thorax (HP:0001591)2.74681756
24Esophageal atresia (HP:0002032)2.64417569
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.61448493
26Hypoplastic ischia (HP:0003175)2.52943349
27Abnormality of the ischium (HP:0003174)2.48136751
28Abnormality of the labia minora (HP:0012880)2.45893199
293-Methylglutaconic aciduria (HP:0003535)2.44848489
30Type I transferrin isoform profile (HP:0003642)2.38324624
31Infertility (HP:0000789)2.34582848
32Abnormality of macular pigmentation (HP:0008002)2.34131736
33Stage 5 chronic kidney disease (HP:0003774)2.31601429
34Spontaneous abortion (HP:0005268)2.30284853
35Atonic seizures (HP:0010819)2.27690510
36Resting tremor (HP:0002322)2.26288637
37Anterior segment dysgenesis (HP:0007700)2.23871611
38Gastrointestinal atresia (HP:0002589)2.23427539
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20112161
40Abnormal urine output (HP:0012590)2.19483593
41Aplasia/Hypoplasia of the earlobes (HP:0009906)2.18430035
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.16598077
43Molar tooth sign on MRI (HP:0002419)2.10237940
44Abnormality of midbrain morphology (HP:0002418)2.10237940
45Occipital encephalocele (HP:0002085)2.08298918
46Polyuria (HP:0000103)2.08167838
47Tubulointerstitial abnormality (HP:0001969)2.06626593
48Potter facies (HP:0002009)2.03874427
49Facial shape deformation (HP:0011334)2.03874427
50Retinal atrophy (HP:0001105)2.03446073
51Small intestinal stenosis (HP:0012848)2.03398126
52Duodenal stenosis (HP:0100867)2.03398126
53Sensory axonal neuropathy (HP:0003390)2.03051448
54Type II lissencephaly (HP:0007260)2.01698362
55Increased density of long bones (HP:0006392)1.98843170
56Renal dysplasia (HP:0000110)1.98813347
57Meckel diverticulum (HP:0002245)1.98544804
58Abnormality of the duodenum (HP:0002246)1.97642402
59Chronic bronchitis (HP:0004469)1.97112349
60Abnormality of chromosome stability (HP:0003220)1.96684318
61Abnormality of the renal cortex (HP:0011035)1.94281197
62Abnormality of the ileum (HP:0001549)1.93644681
63Median cleft lip (HP:0000161)1.90837969
64Polydipsia (HP:0001959)1.90350820
65Abnormal drinking behavior (HP:0030082)1.90350820
66Abnormality of DNA repair (HP:0003254)1.89027485
67Popliteal pterygium (HP:0009756)1.88704548
68Abnormal protein glycosylation (HP:0012346)1.87323361
69Abnormal glycosylation (HP:0012345)1.87323361
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87323361
71Abnormal protein N-linked glycosylation (HP:0012347)1.87323361
72Genital tract atresia (HP:0001827)1.84051639
73Vaginal atresia (HP:0000148)1.81498465
74Generalized aminoaciduria (HP:0002909)1.81222228
75Abnormal rod and cone electroretinograms (HP:0008323)1.80905520
76Abnormality of the parietal bone (HP:0002696)1.80230906
77Abnormality of renal excretion (HP:0011036)1.77943646
78Small hand (HP:0200055)1.75799913
79Intellectual disability, moderate (HP:0002342)1.75222095
80Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75027340
81Horizontal nystagmus (HP:0000666)1.73217466
82Abnormality of chloride homeostasis (HP:0011422)1.72633525
83Septo-optic dysplasia (HP:0100842)1.70357435
84Anophthalmia (HP:0000528)1.69992564
85Hypoplastic labia majora (HP:0000059)1.69748861
86Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.69600698
87Abnormality of cochlea (HP:0000375)1.68237708
88Pendular nystagmus (HP:0012043)1.67454094
89Male infertility (HP:0003251)1.66202262
90Triphalangeal thumb (HP:0001199)1.65996634
91Maternal diabetes (HP:0009800)1.65803293
92Bilateral microphthalmos (HP:0007633)1.65313228
93Absent septum pellucidum (HP:0001331)1.63781661
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63206639
95Abnormality of alanine metabolism (HP:0010916)1.63206639
96Hyperalaninemia (HP:0003348)1.63206639
97Hypomagnesemia (HP:0002917)1.61297060
98Hypothermia (HP:0002045)1.60471682
99Double outlet right ventricle (HP:0001719)1.59382696
100Congenital malformation of the right heart (HP:0011723)1.59382696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.99007591
2PLK45.92405001
3PLK22.93157339
4FGFR22.91330177
5BRD42.40269702
6STK38L2.34946801
7BMPR1B2.34609456
8CAMK1G2.29705282
9CDK192.17937621
10ZAK2.14953042
11MST42.02959385
12MET1.99599008
13MAP4K21.89173782
14NUAK11.81899870
15INSRR1.72850975
16DDR21.72797741
17TNIK1.67946189
18WNK31.63796427
19WNK41.57380949
20OXSR11.57328905
21DYRK31.55041901
22MAP3K41.52480522
23MAP2K21.44706142
24TAF11.41986295
25TTK1.41852987
26PTK2B1.41313761
27CASK1.38949405
28MAPK151.30892186
29STK381.30154586
30MST1R1.28802241
31MKNK21.27778823
32STK391.25760600
33TXK1.20178449
34FRK1.17692529
35TESK11.16527393
36BRSK21.15674646
37TYRO31.15574104
38TRIM281.13324942
39PDK21.07359758
40VRK21.07083477
41BUB11.04851191
42MAP2K71.03161765
43EPHA40.99440002
44ERBB40.99089207
45VRK10.98110291
46PLK10.97904295
47STK160.96819631
48FGFR10.95825861
49PBK0.92335808
50AKT30.88143072
51FGR0.81935327
52NEK10.81130990
53PASK0.79002495
54PLK30.76130048
55MAP3K90.74496534
56CDC70.74246861
57NLK0.73188808
58TGFBR10.72298328
59MAP3K60.71444034
60WNK10.68298589
61TLK10.67231253
62PINK10.66244965
63RET0.64638731
64NEK20.64516772
65STK100.62412193
66MKNK10.60002522
67NEK60.54825929
68WEE10.53535211
69CHEK10.52404380
70PIK3CG0.50498166
71CAMK10.47344333
72PRKG10.45402270
73SGK10.44690321
74BMX0.44372776
75MAP2K10.43704633
76MAP2K40.41951429
77GRK10.41405461
78ACVR1B0.40875861
79BRSK10.39554584
80PRKACB0.38073128
81ATR0.35398858
82ROCK10.34707602
83EIF2AK30.34693239
84CDK30.34107681
85PRKCE0.30403785
86PDK10.29957219
87MAPK130.29658229
88CDK70.27157062
89FLT30.26464825
90SRPK10.25810383
91CDK20.25250895
92ADRBK10.24789679
93EGFR0.23694343
94RPS6KA40.23604639
95DYRK1A0.22175040
96CSF1R0.21610982
97CDK10.21442259
98ATM0.21014714
99PDGFRB0.20757183
100PRKD30.20153224

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.94114135
2Basal transcription factors_Homo sapiens_hsa030223.46546540
3Fatty acid biosynthesis_Homo sapiens_hsa000613.04179916
4Olfactory transduction_Homo sapiens_hsa047403.02950717
5Propanoate metabolism_Homo sapiens_hsa006402.56883115
6RNA transport_Homo sapiens_hsa030132.55573962
7Proteasome_Homo sapiens_hsa030502.35099984
8Homologous recombination_Homo sapiens_hsa034402.13713982
9Butanoate metabolism_Homo sapiens_hsa006502.09307675
10Parkinsons disease_Homo sapiens_hsa050121.90684973
11Nitrogen metabolism_Homo sapiens_hsa009101.88246403
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87852624
13Huntingtons disease_Homo sapiens_hsa050161.87030413
14Fanconi anemia pathway_Homo sapiens_hsa034601.81190623
15RNA degradation_Homo sapiens_hsa030181.75127031
16Oxidative phosphorylation_Homo sapiens_hsa001901.66002539
17Phototransduction_Homo sapiens_hsa047441.61790481
18Nucleotide excision repair_Homo sapiens_hsa034201.61124324
19Non-homologous end-joining_Homo sapiens_hsa034501.60446652
20ABC transporters_Homo sapiens_hsa020101.54815312
21Retinol metabolism_Homo sapiens_hsa008301.43954220
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41172222
23Mismatch repair_Homo sapiens_hsa034301.40097365
24RNA polymerase_Homo sapiens_hsa030201.40023078
25Oocyte meiosis_Homo sapiens_hsa041141.38283485
26Protein export_Homo sapiens_hsa030601.37437297
27Fatty acid degradation_Homo sapiens_hsa000711.35697209
28beta-Alanine metabolism_Homo sapiens_hsa004101.35057263
29Ribosome_Homo sapiens_hsa030101.30318390
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28451130
31Fat digestion and absorption_Homo sapiens_hsa049751.28043240
32Pyruvate metabolism_Homo sapiens_hsa006201.24742698
33Hedgehog signaling pathway_Homo sapiens_hsa043401.23756136
34Basal cell carcinoma_Homo sapiens_hsa052171.23025791
35Fatty acid metabolism_Homo sapiens_hsa012121.16717385
36Glycerolipid metabolism_Homo sapiens_hsa005611.12421677
37Arginine and proline metabolism_Homo sapiens_hsa003301.12362814
38Dorso-ventral axis formation_Homo sapiens_hsa043201.09721163
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08264496
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04735663
41Collecting duct acid secretion_Homo sapiens_hsa049661.03523297
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03152766
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.01566158
44Wnt signaling pathway_Homo sapiens_hsa043101.00734319
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99994570
46Tight junction_Homo sapiens_hsa045300.99164872
47Selenocompound metabolism_Homo sapiens_hsa004500.97954668
48Cell cycle_Homo sapiens_hsa041100.97685647
49One carbon pool by folate_Homo sapiens_hsa006700.96633822
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.90348899
51Vitamin digestion and absorption_Homo sapiens_hsa049770.89549774
52Alzheimers disease_Homo sapiens_hsa050100.88525146
53Taste transduction_Homo sapiens_hsa047420.88090773
54Peroxisome_Homo sapiens_hsa041460.87343860
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85775518
56Purine metabolism_Homo sapiens_hsa002300.85362956
57TGF-beta signaling pathway_Homo sapiens_hsa043500.84189889
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82942149
59Cardiac muscle contraction_Homo sapiens_hsa042600.82831724
60mRNA surveillance pathway_Homo sapiens_hsa030150.82080559
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.81350971
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79559917
63Protein digestion and absorption_Homo sapiens_hsa049740.77346628
64Chemical carcinogenesis_Homo sapiens_hsa052040.76974691
65Regulation of autophagy_Homo sapiens_hsa041400.75614261
66Fatty acid elongation_Homo sapiens_hsa000620.75453153
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72727731
68Glutathione metabolism_Homo sapiens_hsa004800.71309261
69Calcium signaling pathway_Homo sapiens_hsa040200.69797349
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69446066
71Lysine degradation_Homo sapiens_hsa003100.68372700
72Linoleic acid metabolism_Homo sapiens_hsa005910.67144618
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66119744
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.65229187
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60930015
76Nicotine addiction_Homo sapiens_hsa050330.58895376
77PPAR signaling pathway_Homo sapiens_hsa033200.58043222
78Tryptophan metabolism_Homo sapiens_hsa003800.57691948
79Legionellosis_Homo sapiens_hsa051340.57084687
80Metabolic pathways_Homo sapiens_hsa011000.56496179
81ECM-receptor interaction_Homo sapiens_hsa045120.53301590
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52380955
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50689616
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.50335828
85Hippo signaling pathway_Homo sapiens_hsa043900.45560329
86Adherens junction_Homo sapiens_hsa045200.45452399
87Spliceosome_Homo sapiens_hsa030400.44558211
88Histidine metabolism_Homo sapiens_hsa003400.42880089
89Arginine biosynthesis_Homo sapiens_hsa002200.42800935
90Phenylalanine metabolism_Homo sapiens_hsa003600.42626348
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41719856
92N-Glycan biosynthesis_Homo sapiens_hsa005100.41203612
93Steroid biosynthesis_Homo sapiens_hsa001000.40502232
94Base excision repair_Homo sapiens_hsa034100.40321466
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39397016
96Bile secretion_Homo sapiens_hsa049760.36922198
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35971321
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34614674
99DNA replication_Homo sapiens_hsa030300.32750235
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30230315

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