SLED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.30284765
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.88201443
3cellular extravasation (GO:0045123)5.67081071
4response to peptidoglycan (GO:0032494)5.57174497
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.46527756
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.46527756
7modulation by symbiont of host immune response (GO:0052553)5.46527756
8positive regulation by symbiont of host defense response (GO:0052509)5.46527756
9modulation by symbiont of host defense response (GO:0052031)5.46527756
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.46527756
11positive regulation of gamma-delta T cell activation (GO:0046645)5.06889257
12macrophage activation involved in immune response (GO:0002281)4.84635194
13negative regulation of interleukin-12 production (GO:0032695)4.82086763
14microglial cell activation (GO:0001774)4.80418510
15detection of external biotic stimulus (GO:0098581)4.72128424
16macrophage activation (GO:0042116)4.63461482
17detection of other organism (GO:0098543)4.46777456
18positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.45329654
19neutrophil mediated immunity (GO:0002446)4.37279485
20neutrophil activation involved in immune response (GO:0002283)4.34361652
21detection of biotic stimulus (GO:0009595)4.32502341
22regulation of B cell receptor signaling pathway (GO:0050855)4.22919230
23response to host immune response (GO:0052572)4.17843005
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17843005
25regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.03724418
26regulation of interferon-beta biosynthetic process (GO:0045357)4.02445933
27regulation of gamma-delta T cell activation (GO:0046643)3.84288747
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83538443
29response to host (GO:0075136)3.83538443
30response to host defenses (GO:0052200)3.83538443
31negative regulation of cell killing (GO:0031342)3.78908125
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78908125
33myeloid leukocyte mediated immunity (GO:0002444)3.74655504
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.73844502
35regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.57747762
36detection of bacterium (GO:0016045)3.57042222
37neutrophil activation (GO:0042119)3.54320114
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51137094
39response to muramyl dipeptide (GO:0032495)3.49263958
40regulation of gamma-delta T cell differentiation (GO:0045586)3.46434623
41myeloid cell activation involved in immune response (GO:0002275)3.46407430
42positive regulation of toll-like receptor signaling pathway (GO:0034123)3.46088511
43T-helper 1 type immune response (GO:0042088)3.44267826
44dosage compensation (GO:0007549)3.44037849
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.43201374
46positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.40789199
47granulocyte activation (GO:0036230)3.35438260
48defense response to protozoan (GO:0042832)3.35101736
49regulation of macrophage cytokine production (GO:0010935)3.34230365
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33901987
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.30223999
52negative regulation of T-helper cell differentiation (GO:0045623)3.30223999
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.27118941
54production of molecular mediator involved in inflammatory response (GO:0002532)3.25446669
55negative regulation of B cell mediated immunity (GO:0002713)3.20564008
56negative regulation of immunoglobulin mediated immune response (GO:0002890)3.20564008
57germinal center formation (GO:0002467)3.20449490
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19997052
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17917726
60leukocyte migration involved in inflammatory response (GO:0002523)3.16359645
61regulation of interleukin-6 biosynthetic process (GO:0045408)3.10020410
62respiratory burst (GO:0045730)3.08267130
63negative regulation of interleukin-17 production (GO:0032700)3.05936849
64positive regulation of mast cell activation (GO:0033005)3.04809315
65response to protozoan (GO:0001562)3.03935835
66negative regulation of T cell mediated immunity (GO:0002710)2.98401727
67regulation of interleukin-8 biosynthetic process (GO:0045414)2.98067105
68neutrophil chemotaxis (GO:0030593)2.97589897
69regulation of mast cell degranulation (GO:0043304)2.95121577
70regulation of toll-like receptor signaling pathway (GO:0034121)2.94799218
71regulation of mast cell activation (GO:0033003)2.94311502
72positive regulation of interferon-alpha production (GO:0032727)2.94102138
73negative regulation of erythrocyte differentiation (GO:0045647)2.92705864
74cytokine secretion (GO:0050663)2.91700564
75cellular response to ethanol (GO:0071361)2.90939780
76B cell receptor signaling pathway (GO:0050853)2.90859567
77negative regulation of B cell proliferation (GO:0030889)2.90581390
78neutrophil migration (GO:1990266)2.89839025
79negative regulation of interleukin-6 production (GO:0032715)2.89608891
80negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87149799
81response to manganese ion (GO:0010042)2.86603862
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86162021
83I-kappaB phosphorylation (GO:0007252)2.85704040
84regulation of interferon-alpha production (GO:0032647)2.85257269
85hepatocyte apoptotic process (GO:0097284)2.84269891
86positive regulation of macrophage cytokine production (GO:0060907)2.84002411
87myeloid leukocyte activation (GO:0002274)2.82030987
88regulation of necroptotic process (GO:0060544)2.81927189
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.80808404
90regulation of T-helper 2 cell differentiation (GO:0045628)2.80758448
91tolerance induction (GO:0002507)2.77414465
92leukocyte aggregation (GO:0070486)2.77088043
93regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.76799770
94regulation of mast cell activation involved in immune response (GO:0033006)2.76450494
95negative regulation of adaptive immune response (GO:0002820)2.75558564
96mature B cell differentiation involved in immune response (GO:0002313)2.73555808
97negative regulation of leukocyte mediated immunity (GO:0002704)2.73329341
98negative regulation of toll-like receptor signaling pathway (GO:0034122)2.71494963
99regulation of platelet aggregation (GO:0090330)2.70940836
100positive regulation of interferon-beta production (GO:0032728)2.69174300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.78009380
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.33367908
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.81470940
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.71285181
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.49619553
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43021321
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.34902655
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.25249912
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.24917158
10SCL_19346495_ChIP-Seq_HPC-7_Human3.04443690
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.97045535
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94775166
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.90206642
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83007719
15RUNX_20019798_ChIP-Seq_JUKART_Human2.80059128
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.79748275
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.50603608
18VDR_24787735_ChIP-Seq_THP-1_Human2.43549546
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40548375
20VDR_24763502_ChIP-Seq_THP-1_Human2.23004308
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22969671
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.19600347
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17725436
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05840112
25SPI1_23127762_ChIP-Seq_K562_Human2.05130776
26SPI1_23547873_ChIP-Seq_NB4_Human2.04013527
27MYB_26560356_Chip-Seq_TH2_Human2.00167773
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.93869187
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83091695
30GATA1_22025678_ChIP-Seq_K562_Human1.82925602
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.78063813
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75629998
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75539478
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73585228
35MYB_26560356_Chip-Seq_TH1_Human1.66196562
36GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61585096
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60839664
38PU_27001747_Chip-Seq_BMDM_Mouse1.57702997
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.56493770
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.53415595
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53046322
42VDR_21846776_ChIP-Seq_THP-1_Human1.50104402
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49349752
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46427600
45GATA3_27048872_Chip-Seq_THYMUS_Human1.44932376
46MAF_26560356_Chip-Seq_TH1_Human1.42513141
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42119178
48TCF7_22412390_ChIP-Seq_EML_Mouse1.40961564
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38779116
50GATA1_19941826_ChIP-Seq_K562_Human1.33315437
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32932113
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31833763
53* GATA3_26560356_Chip-Seq_TH2_Human1.31635540
54GATA2_19941826_ChIP-Seq_K562_Human1.31570057
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.30143646
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28060021
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22915473
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18083462
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15541155
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.12009879
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11464548
62UTX_26944678_Chip-Seq_JUKART_Human1.11210726
63TP53_16413492_ChIP-PET_HCT116_Human1.11079471
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.10572660
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10373858
66GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09163111
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06429049
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02744156
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02311394
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01313911
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01273312
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97469210
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95466040
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94961131
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94660039
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93454181
77KDM2B_26808549_Chip-Seq_DND41_Human0.92839904
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92553008
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90652378
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89626196
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89059359
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88656889
83FOXO3_23340844_ChIP-Seq_DLD1_Human0.88235377
84MYC_22102868_ChIP-Seq_BL_Human0.84866660
85EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83366916
86SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82109650
87* SMRT_27268052_Chip-Seq_Bcells_Human0.81895125
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80540670
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79516972
90EGR1_19032775_ChIP-ChIP_M12_Human0.78522610
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78479948
92ER_23166858_ChIP-Seq_MCF-7_Human0.77817712
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77178860
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76659002
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76595381
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76122951
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76006182
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74706879
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71089512
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70782668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.70887862
2MP0003303_peritoneal_inflammation4.42658661
3MP0000569_abnormal_digit_pigmentation3.38844366
4MP0003436_decreased_susceptibility_to3.35129379
5MP0001835_abnormal_antigen_presentation3.02275611
6MP0002419_abnormal_innate_immunity2.66589557
7MP0008260_abnormal_autophagy2.64640492
8MP0005451_abnormal_body_composition2.58830195
9MP0003828_pulmonary_edema2.58510751
10MP0003172_abnormal_lysosome_physiology2.27421962
11MP0005464_abnormal_platelet_physiology2.25980927
12MP0001800_abnormal_humoral_immune2.23296311
13MP0003656_abnormal_erythrocyte_physiolo2.22043404
14MP0005025_abnormal_response_to2.19576849
15MP0005000_abnormal_immune_tolerance2.13100211
16MP0009785_altered_susceptibility_to2.11292656
17MP0000685_abnormal_immune_system2.08378657
18MP0003300_gastrointestinal_ulcer2.03528273
19MP0002723_abnormal_immune_serum2.03404575
20MP0002452_abnormal_antigen_presenting2.02338943
21MP0001545_abnormal_hematopoietic_system1.95610322
22MP0005397_hematopoietic_system_phenotyp1.95610322
23MP0009278_abnormal_bone_marrow1.94220878
24MP0002420_abnormal_adaptive_immunity1.92366430
25MP0001819_abnormal_immune_cell1.89820060
26MP0009764_decreased_sensitivity_to1.86463137
27MP0002148_abnormal_hypersensitivity_rea1.81431375
28MP0003191_abnormal_cellular_cholesterol1.80491861
29MP0006082_CNS_inflammation1.78510059
30MP0004510_myositis1.77191690
31MP0004947_skin_inflammation1.77067698
32MP0001533_abnormal_skeleton_physiology1.74951702
33MP0005387_immune_system_phenotype1.74829229
34MP0001790_abnormal_immune_system1.74829229
35MP0008004_abnormal_stomach_pH1.68842862
36MP0004883_abnormal_blood_vessel1.67094751
37MP0002396_abnormal_hematopoietic_system1.65813125
38MP0001853_heart_inflammation1.60908917
39MP0002332_abnormal_exercise_endurance1.59485171
40MP0002132_abnormal_respiratory_system1.55713129
41MP0002166_altered_tumor_susceptibility1.53850610
42MP0002405_respiratory_system_inflammati1.53778943
43MP0003075_altered_response_to1.51696895
44MP0005671_abnormal_response_to1.50188882
45MP0001845_abnormal_inflammatory_respons1.50168978
46MP0002398_abnormal_bone_marrow1.49108710
47MP0005164_abnormal_response_to1.47856379
48MP0001851_eye_inflammation1.46586417
49MP0000716_abnormal_immune_system1.45242453
50MP0010352_gastrointestinal_tract_polyps1.43409523
51MP0000015_abnormal_ear_pigmentation1.37824107
52MP0003763_abnormal_thymus_physiology1.35922265
53MP0003221_abnormal_cardiomyocyte_apopto1.34865077
54MP0005076_abnormal_cell_differentiation1.34315590
55MP0002998_abnormal_bone_remodeling1.32019874
56MP0000689_abnormal_spleen_morphology1.27323290
57MP0004130_abnormal_muscle_cell1.23947830
58MP0002722_abnormal_immune_system1.23221390
59MP0000465_gastrointestinal_hemorrhage1.17279907
60MP0004808_abnormal_hematopoietic_stem1.15282897
61MP0003045_fibrosis1.15082211
62MP0010155_abnormal_intestine_physiology1.14564950
63MP0004381_abnormal_hair_follicle1.14455652
64MP0002429_abnormal_blood_cell1.14183323
65MP0004484_altered_response_of1.13793261
66MP0003787_abnormal_imprinting1.12767248
67MP0003690_abnormal_glial_cell1.12380056
68MP0005058_abnormal_lysosome_morphology1.12282711
69MP0008469_abnormal_protein_level1.11135261
70MP0005310_abnormal_salivary_gland1.07980332
71MP0002006_tumorigenesis1.06591893
72MP0003866_abnormal_defecation1.03161941
73MP0000604_amyloidosis1.01407774
74MP0003195_calcinosis0.99496438
75MP0000858_altered_metastatic_potential0.98454313
76MP0003091_abnormal_cell_migration0.97507626
77MP0005166_decreased_susceptibility_to0.92235265
78MP0003448_altered_tumor_morphology0.91582644
79MP0005666_abnormal_adipose_tissue0.90419004
80MP0005174_abnormal_tail_pigmentation0.89947361
81MP0009763_increased_sensitivity_to0.89373375
82MP0002138_abnormal_hepatobiliary_system0.86658030
83MP0003252_abnormal_bile_duct0.86524274
84MP0000703_abnormal_thymus_morphology0.85480827
85MP0009765_abnormal_xenobiotic_induced0.85432830
86MP0000249_abnormal_blood_vessel0.84036915
87MP0008057_abnormal_DNA_replication0.78558434
88MP0002102_abnormal_ear_morphology0.76955125
89MP0002009_preneoplasia0.75459990
90MP0005376_homeostasis/metabolism_phenot0.73734953
91MP0003183_abnormal_peptide_metabolism0.73246426
92MP0000343_altered_response_to0.72994154
93MP0005390_skeleton_phenotype0.69075877
94MP0005266_abnormal_metabolism0.66436366
95MP0001663_abnormal_digestive_system0.63176421
96MP0005535_abnormal_body_temperature0.62943457
97MP0003632_abnormal_nervous_system0.62843599
98MP0003453_abnormal_keratinocyte_physiol0.62570647
99MP0009115_abnormal_fat_cell0.62435510
100MP0000609_abnormal_liver_physiology0.59492709

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.79493993
2Optic neuritis (HP:0100653)5.48543041
3Retrobulbar optic neuritis (HP:0100654)5.48543041
4Orchitis (HP:0100796)5.31224922
5Recurrent abscess formation (HP:0002722)5.30692142
6Myositis (HP:0100614)5.20896461
7Eczematoid dermatitis (HP:0000976)5.14026188
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.75417877
9Recurrent gram-negative bacterial infections (HP:0005420)4.54601657
10Stomatitis (HP:0010280)4.27176406
11Gingival bleeding (HP:0000225)4.18426687
12Gastrointestinal infarctions (HP:0005244)4.17937999
13Elevated erythrocyte sedimentation rate (HP:0003565)4.16852146
14Keratoconjunctivitis sicca (HP:0001097)3.97727335
15Abnormality of macrophages (HP:0004311)3.92352479
16Arterial thrombosis (HP:0004420)3.73649761
17Recurrent fungal infections (HP:0002841)3.71318331
18Keratoconjunctivitis (HP:0001096)3.67749001
19Recurrent skin infections (HP:0001581)3.65864095
20Peritonitis (HP:0002586)3.57030873
21Gingivitis (HP:0000230)3.55899261
22Prolonged bleeding time (HP:0003010)3.34093302
23Mediastinal lymphadenopathy (HP:0100721)3.31595709
24Spontaneous hematomas (HP:0007420)3.26985124
25T lymphocytopenia (HP:0005403)3.22231102
26Amyloidosis (HP:0011034)3.16883554
27Epistaxis (HP:0000421)3.15792814
28Abnormality of T cell number (HP:0011839)3.12284054
29Meningitis (HP:0001287)2.98913513
30Chronic mucocutaneous candidiasis (HP:0002728)2.97460928
31Recurrent cutaneous fungal infections (HP:0011370)2.97460928
32Vasculitis (HP:0002633)2.95310839
33Hemoptysis (HP:0002105)2.94117154
34Slow saccadic eye movements (HP:0000514)2.88643391
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.83342057
36Encephalitis (HP:0002383)2.82347566
37Chest pain (HP:0100749)2.81517329
38Gangrene (HP:0100758)2.79584624
39Subacute progressive viral hepatitis (HP:0006572)2.76881015
40Leukocytosis (HP:0001974)2.74918987
41Chronic obstructive pulmonary disease (HP:0006510)2.72752683
42Obstructive lung disease (HP:0006536)2.72752683
43Pulmonary embolism (HP:0002204)2.71666575
44Anorexia (HP:0002039)2.65414434
45Urticaria (HP:0001025)2.65308405
46Episodic fever (HP:0001954)2.64375918
47Papillary thyroid carcinoma (HP:0002895)2.58783637
48Abnormality of the peritoneum (HP:0002585)2.54960317
49Autoimmune thrombocytopenia (HP:0001973)2.51433503
50Myocardial infarction (HP:0001658)2.44615449
51Pulmonary infiltrates (HP:0002113)2.43235555
52Recurrent viral infections (HP:0004429)2.43087607
53Autoimmune hemolytic anemia (HP:0001890)2.39063741
54Cellulitis (HP:0100658)2.38603935
55Postural instability (HP:0002172)2.38096867
56Abnormality of the endocardium (HP:0004306)2.34719816
57Neoplasm of the tracheobronchial system (HP:0100552)2.34486415
58Increased IgE level (HP:0003212)2.28822919
59Periodontitis (HP:0000704)2.26048661
60Vertigo (HP:0002321)2.24881456
61Acute hepatic failure (HP:0006554)2.18743128
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.18302174
63Abnormal platelet volume (HP:0011876)2.16006665
64Thrombophlebitis (HP:0004418)2.15700053
65Resting tremor (HP:0002322)2.12436546
66Difficulty running (HP:0009046)2.11946014
67Abnormality of T cells (HP:0002843)2.11449409
68Muscle fiber splitting (HP:0003555)2.11326954
69Inflammation of the large intestine (HP:0002037)2.10996901
70Viral hepatitis (HP:0006562)2.10345902
71Acute myeloid leukemia (HP:0004808)2.09856408
72Hematochezia (HP:0002573)2.05375372
73Colitis (HP:0002583)2.04261394
74Eosinophilia (HP:0001880)2.03827988
75Abnormality of the fingertips (HP:0001211)2.03596837
76Gastrointestinal inflammation (HP:0004386)2.00937668
77Polyneuropathy (HP:0001271)2.00549505
78Interstitial pulmonary disease (HP:0006530)2.00167863
79Abnormality of the pleura (HP:0002103)1.98104363
80Increased cerebral lipofuscin (HP:0011813)1.96673831
81Glomerulopathy (HP:0100820)1.96571186
82Granulocytopenia (HP:0001913)1.93687175
83Keratitis (HP:0000491)1.92567225
84Alveolar cell carcinoma (HP:0006519)1.91495456
85Abnormality of iron homeostasis (HP:0011031)1.83975772
86Conjunctival telangiectasia (HP:0000524)1.83934454
87Stomach cancer (HP:0012126)1.83484192
88Osteomyelitis (HP:0002754)1.83117854
89Increased mean platelet volume (HP:0011877)1.82438782
90Menorrhagia (HP:0000132)1.81393372
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.78854687
92Petechiae (HP:0000967)1.78624223
93Systemic lupus erythematosus (HP:0002725)1.78071718
94Amaurosis fugax (HP:0100576)1.76153190
95Increased serum ferritin (HP:0003281)1.75984472
96Acne (HP:0001061)1.73361329
97Facial diplegia (HP:0001349)1.72204346
98Neonatal hypoglycemia (HP:0001998)1.70735216
99Disinhibition (HP:0000734)1.70295166
100Hypochromic microcytic anemia (HP:0004840)1.70283465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.68292713
2IRAK43.43812720
3MAP2K33.36094857
4BLK3.09710320
5IRAK12.82654024
6TAOK32.60496504
7IRAK22.52322045
8IKBKE2.48381862
9MAP3K142.39827300
10CSK2.12187022
11PIK3CG2.04051558
12BMPR21.93832938
13JAK31.88336518
14MAP3K31.77469364
15GRK61.75925606
16TYK21.75519128
17ZAP701.69919131
18TXK1.68881716
19MAP3K21.65531720
20SYK1.64843035
21MAP4K11.62492036
22PRPF4B1.61899962
23FES1.59893070
24FGR1.53763430
25FRK1.51321804
26MAP3K61.49775885
27SGK21.48192956
28MATK1.47495207
29TBK11.47208521
30MAP3K11.45611680
31BTK1.39737929
32FGFR31.36040153
33HCK1.34472148
34JAK21.31369053
35BRD41.31095042
36EPHB11.26793200
37ACVR1B1.24690515
38KSR21.20581412
39SGK31.19937586
40TAOK11.16670261
41IKBKB1.15059648
42JAK11.14669097
43TEC1.13672244
44WNK11.11272181
45LYN1.07634598
46PTK2B1.03810499
47CAMK1D1.01056381
48MARK30.95762102
49TAOK20.95119571
50KIT0.94668684
51TRPM70.89076264
52TNK20.88994827
53EPHA30.87784584
54LCK0.85181287
55MARK20.83929696
56PIM10.81713595
57MAP3K50.78944508
58CHUK0.78584108
59MAP3K110.77591925
60SGK2230.76984193
61SGK4940.76984193
62TGFBR20.76380664
63CDK120.74268380
64MAP3K130.73300636
65STK40.72781162
66YES10.72735192
67PDK10.72609248
68ERN10.71313811
69ITK0.70200317
70CAMK1G0.70193473
71LRRK20.69786684
72MAPK70.67456575
73ERBB20.66880172
74IRAK30.66112032
75STK110.64991022
76PDPK10.61749824
77RAF10.61599716
78CSF1R0.61239766
79KSR10.58532470
80NLK0.57869198
81MAP2K40.56611967
82AKT30.55792826
83PRKAA20.53619156
84MAP3K70.52145209
85HIPK20.49402187
86SGK10.47845106
87EGFR0.45562902
88MAP2K60.43653671
89GRK50.43494980
90PDGFRB0.43464626
91DMPK0.43171497
92CAMK40.42428091
93GRK70.42062323
94RET0.39519205
95LATS10.38907525
96FYN0.38709663
97CDC42BPA0.38368531
98PRKCQ0.36295816
99MOS0.33719104
100MAPK120.33298035

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.04122683
2Osteoclast differentiation_Homo sapiens_hsa043802.85588413
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.63313142
4B cell receptor signaling pathway_Homo sapiens_hsa046622.37549029
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31632820
6Staphylococcus aureus infection_Homo sapiens_hsa051502.29947431
7Legionellosis_Homo sapiens_hsa051342.14237784
8Tuberculosis_Homo sapiens_hsa051522.09095507
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.06728823
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88215120
11Malaria_Homo sapiens_hsa051441.87847320
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83911435
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81450502
14TNF signaling pathway_Homo sapiens_hsa046681.76306775
15Measles_Homo sapiens_hsa051621.69590621
16Acute myeloid leukemia_Homo sapiens_hsa052211.63894119
17T cell receptor signaling pathway_Homo sapiens_hsa046601.60910688
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56964918
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.52780382
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50734051
21Influenza A_Homo sapiens_hsa051641.50254293
22Non-small cell lung cancer_Homo sapiens_hsa052231.47716138
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.47535268
24Toxoplasmosis_Homo sapiens_hsa051451.43560386
25Hematopoietic cell lineage_Homo sapiens_hsa046401.42577907
26Platelet activation_Homo sapiens_hsa046111.42414254
27Chemokine signaling pathway_Homo sapiens_hsa040621.40093547
28Dorso-ventral axis formation_Homo sapiens_hsa043201.32606917
29Pertussis_Homo sapiens_hsa051331.32220342
30Hepatitis B_Homo sapiens_hsa051611.30414845
31Prolactin signaling pathway_Homo sapiens_hsa049171.25790746
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23705666
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.19439701
34Pancreatic cancer_Homo sapiens_hsa052121.18523721
35VEGF signaling pathway_Homo sapiens_hsa043701.16652495
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.14611427
37Hepatitis C_Homo sapiens_hsa051601.14601020
38FoxO signaling pathway_Homo sapiens_hsa040681.12180547
39Chronic myeloid leukemia_Homo sapiens_hsa052201.11647256
40Amoebiasis_Homo sapiens_hsa051461.05532227
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02697718
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99240146
43Complement and coagulation cascades_Homo sapiens_hsa046100.98576096
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97621886
45Salmonella infection_Homo sapiens_hsa051320.96443959
46Renal cell carcinoma_Homo sapiens_hsa052110.93952517
47Fatty acid biosynthesis_Homo sapiens_hsa000610.93733274
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.93196673
49African trypanosomiasis_Homo sapiens_hsa051430.92531394
50Herpes simplex infection_Homo sapiens_hsa051680.91796038
51Insulin resistance_Homo sapiens_hsa049310.91454570
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87939495
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87140094
54Phagosome_Homo sapiens_hsa041450.85796298
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85268854
56Apoptosis_Homo sapiens_hsa042100.84374899
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83077735
58Inositol phosphate metabolism_Homo sapiens_hsa005620.82405095
59Graft-versus-host disease_Homo sapiens_hsa053320.82020578
60GnRH signaling pathway_Homo sapiens_hsa049120.81958029
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81223927
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.79883455
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79682223
64Type II diabetes mellitus_Homo sapiens_hsa049300.78424935
65Other glycan degradation_Homo sapiens_hsa005110.77847805
66mTOR signaling pathway_Homo sapiens_hsa041500.77315609
67Rheumatoid arthritis_Homo sapiens_hsa053230.76241511
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74645934
69Allograft rejection_Homo sapiens_hsa053300.73648081
70Endometrial cancer_Homo sapiens_hsa052130.72915505
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72747139
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71280913
73Shigellosis_Homo sapiens_hsa051310.69590337
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.69367398
75ErbB signaling pathway_Homo sapiens_hsa040120.68491319
76HIF-1 signaling pathway_Homo sapiens_hsa040660.68212061
77Choline metabolism in cancer_Homo sapiens_hsa052310.67904330
78MAPK signaling pathway_Homo sapiens_hsa040100.67098901
79Notch signaling pathway_Homo sapiens_hsa043300.65164100
80Lysosome_Homo sapiens_hsa041420.64992187
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.62341403
82Autoimmune thyroid disease_Homo sapiens_hsa053200.60525526
83Viral carcinogenesis_Homo sapiens_hsa052030.59521194
84Prostate cancer_Homo sapiens_hsa052150.58914018
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57746691
86Primary immunodeficiency_Homo sapiens_hsa053400.56741063
87Glioma_Homo sapiens_hsa052140.55050929
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.53730692
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52789097
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52622088
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50581783
92Estrogen signaling pathway_Homo sapiens_hsa049150.45400478
93Colorectal cancer_Homo sapiens_hsa052100.43251833
94Asthma_Homo sapiens_hsa053100.43065415
95Arachidonic acid metabolism_Homo sapiens_hsa005900.42508504
96Long-term potentiation_Homo sapiens_hsa047200.41208858
97Type I diabetes mellitus_Homo sapiens_hsa049400.40725251
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39243058
99Epstein-Barr virus infection_Homo sapiens_hsa051690.37037358
100Systemic lupus erythematosus_Homo sapiens_hsa053220.36916875

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