SLFN11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.53880237
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.45033203
3negative regulation of cell killing (GO:0031342)4.45033203
4antigen processing and presentation of endogenous antigen (GO:0019883)4.38198793
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29245061
6response to peptidoglycan (GO:0032494)4.28258601
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.19133879
8negative regulation of interleukin-12 production (GO:0032695)4.12545694
9negative regulation of erythrocyte differentiation (GO:0045647)4.07069233
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.04111743
11cellular extravasation (GO:0045123)4.00082771
12regulation of gamma-delta T cell activation (GO:0046643)3.91906084
13regulation of B cell receptor signaling pathway (GO:0050855)3.81948883
14negative thymic T cell selection (GO:0045060)3.81821890
15negative T cell selection (GO:0043383)3.79512367
16positive thymic T cell selection (GO:0045059)3.74301919
17regulation of gamma-delta T cell differentiation (GO:0045586)3.71424051
18modulation by symbiont of host defense response (GO:0052031)3.69550657
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69550657
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69550657
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.69550657
22modulation by symbiont of host immune response (GO:0052553)3.69550657
23positive regulation by symbiont of host defense response (GO:0052509)3.69550657
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63704996
25immunoglobulin mediated immune response (GO:0016064)3.62929180
26positive regulation of B cell differentiation (GO:0045579)3.56199135
27neutrophil activation involved in immune response (GO:0002283)3.46941501
28detection of other organism (GO:0098543)3.46401336
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.32107318
30macrophage activation involved in immune response (GO:0002281)3.30929077
31B cell receptor signaling pathway (GO:0050853)3.30856114
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.30589297
33T cell migration (GO:0072678)3.25321682
34positive T cell selection (GO:0043368)3.23127290
35response to muramyl dipeptide (GO:0032495)3.21028983
36detection of bacterium (GO:0016045)3.18427591
37regulation of tolerance induction (GO:0002643)3.17066524
38T cell selection (GO:0045058)3.16868170
39positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16499499
40negative regulation of T cell mediated immunity (GO:0002710)3.11807788
41detection of molecule of bacterial origin (GO:0032490)3.10657694
42thymic T cell selection (GO:0045061)3.08426280
43regulation of T cell tolerance induction (GO:0002664)3.05932736
44regulation of interferon-beta biosynthetic process (GO:0045357)3.04894731
45regulation of B cell differentiation (GO:0045577)3.04575414
46detection of external biotic stimulus (GO:0098581)3.04013500
47B cell mediated immunity (GO:0019724)2.95073561
48pinocytosis (GO:0006907)2.94457917
49leukocyte aggregation (GO:0070486)2.92718571
50regulation of antigen processing and presentation (GO:0002577)2.92595082
51response to type I interferon (GO:0034340)2.86431317
52type I interferon signaling pathway (GO:0060337)2.85722051
53cellular response to type I interferon (GO:0071357)2.85722051
54positive regulation of antigen processing and presentation (GO:0002579)2.84776388
55response to interleukin-15 (GO:0070672)2.84729472
56interferon-gamma-mediated signaling pathway (GO:0060333)2.84354925
57defense response to protozoan (GO:0042832)2.82472920
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82242460
59positive regulation of tolerance induction (GO:0002645)2.81158791
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.79022069
61regulation of mast cell degranulation (GO:0043304)2.78943292
62positive regulation of granulocyte differentiation (GO:0030854)2.78799488
63germinal center formation (GO:0002467)2.78616869
64negative regulation of lymphocyte mediated immunity (GO:0002707)2.77824728
65response to protozoan (GO:0001562)2.75946747
66myeloid cell activation involved in immune response (GO:0002275)2.75886256
67regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.73951108
68detection of biotic stimulus (GO:0009595)2.73937179
69positive regulation of interferon-alpha production (GO:0032727)2.72386800
70positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.72315842
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70586197
72response to host immune response (GO:0052572)2.70586197
73microglial cell activation (GO:0001774)2.69819368
74antigen processing and presentation via MHC class Ib (GO:0002475)2.69761852
75macrophage activation (GO:0042116)2.65823298
76regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.64207956
77negative regulation of leukocyte mediated immunity (GO:0002704)2.63956711
78response to host (GO:0075136)2.63754616
79response to host defenses (GO:0052200)2.63754616
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63754616
81regulation of necroptotic process (GO:0060544)2.62049612
82mature B cell differentiation involved in immune response (GO:0002313)2.61529351
83regulation of interleukin-2 biosynthetic process (GO:0045076)2.61351866
84regulation of interferon-alpha production (GO:0032647)2.60939050
85regulation of alpha-beta T cell proliferation (GO:0046640)2.60895458
86myeloid dendritic cell activation (GO:0001773)2.60275605
87regulation of leukocyte degranulation (GO:0043300)2.58196851
88regulation of T-helper 1 cell differentiation (GO:0045625)2.57480060
89respiratory burst (GO:0045730)2.57311781
90regulation of mast cell activation involved in immune response (GO:0033006)2.57082538
91positive regulation of mast cell activation (GO:0033005)2.56165083
92regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55640625
93cellular response to thyroid hormone stimulus (GO:0097067)2.55452962
94positive regulation of type 2 immune response (GO:0002830)2.55262392
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53735752
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53164955
97positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.52999002
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.50881390
99positive regulation of macrophage differentiation (GO:0045651)2.50842130
100cellular response to interleukin-15 (GO:0071350)2.50163360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.46445262
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.70440076
3E2F7_22180533_ChIP-Seq_HELA_Human3.98073476
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.84571727
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54685720
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.48360599
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.41002376
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28582504
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03564782
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96957664
11VDR_21846776_ChIP-Seq_THP-1_Human2.92349636
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.91854825
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79406482
14MYC_22102868_ChIP-Seq_BL_Human2.78901440
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73635069
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72270865
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62010045
18VDR_24763502_ChIP-Seq_THP-1_Human2.56305714
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.52531580
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.51960757
21SCL_19346495_ChIP-Seq_HPC-7_Human2.51616675
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48333905
23MYB_26560356_Chip-Seq_TH2_Human2.47680097
24RUNX_20019798_ChIP-Seq_JUKART_Human2.44678570
25SPI1_23547873_ChIP-Seq_NB4_Human2.37429400
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35161392
27MAF_26560356_Chip-Seq_TH1_Human2.27772523
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23406732
29MYB_26560356_Chip-Seq_TH1_Human2.13915784
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02450043
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.97627559
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97549188
33SPI1_23127762_ChIP-Seq_K562_Human1.92738375
34GATA1_22025678_ChIP-Seq_K562_Human1.91660540
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91566217
36UTX_26944678_Chip-Seq_JUKART_Human1.88324896
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87397925
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.83806589
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82093221
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72580667
41TCF7_22412390_ChIP-Seq_EML_Mouse1.70110307
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67534132
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63435025
44MAF_26560356_Chip-Seq_TH2_Human1.61928029
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60634052
46VDR_24787735_ChIP-Seq_THP-1_Human1.56961460
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56396508
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53173315
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.52453062
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51007524
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50826396
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50237692
53PU_27001747_Chip-Seq_BMDM_Mouse1.45012996
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.42325732
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40908159
56KDM2B_26808549_Chip-Seq_DND41_Human1.36581637
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35379874
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31169556
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.30282677
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27185654
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26699258
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25817062
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.25693571
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23407235
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22206024
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21585241
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21373320
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19439843
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19316339
70GATA1_19941826_ChIP-Seq_K562_Human1.18022422
71CIITA_25753668_ChIP-Seq_RAJI_Human1.16140606
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14850821
73TFEB_21752829_ChIP-Seq_HELA_Human1.14502813
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12112860
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10940489
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10140242
77GATA3_26560356_Chip-Seq_TH2_Human1.08802943
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.01732670
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00836374
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00548503
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97880340
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97550277
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97064333
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94504794
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94442164
86RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93623766
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93534756
88NCOR1_26117541_ChIP-Seq_K562_Human0.93167427
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89736139
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89391434
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88942410
92LXR_22292898_ChIP-Seq_THP-1_Human0.88274821
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87044904
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82755965
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82452342
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80972434
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80467051
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80336292
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79148269
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79088742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.63286469
2MP0003724_increased_susceptibility_to3.21731002
3MP0003303_peritoneal_inflammation3.18686094
4MP0003436_decreased_susceptibility_to3.17617905
5MP0003763_abnormal_thymus_physiology2.58242622
6MP0000685_abnormal_immune_system2.53139167
7MP0005671_abnormal_response_to2.50519971
8MP0005000_abnormal_immune_tolerance2.50412193
9MP0003300_gastrointestinal_ulcer2.46221674
10MP0001790_abnormal_immune_system2.44835003
11MP0005387_immune_system_phenotype2.44835003
12MP0002419_abnormal_innate_immunity2.44157884
13MP0001800_abnormal_humoral_immune2.37176826
14MP0005025_abnormal_response_to2.28165386
15MP0006082_CNS_inflammation2.22473273
16MP0002148_abnormal_hypersensitivity_rea2.21186846
17MP0009785_altered_susceptibility_to2.20749573
18MP0002452_abnormal_antigen_presenting2.16833225
19MP0002723_abnormal_immune_serum2.13126852
20MP0002396_abnormal_hematopoietic_system2.12571514
21MP0002420_abnormal_adaptive_immunity2.06612252
22MP0001819_abnormal_immune_cell2.03451459
23MP0002405_respiratory_system_inflammati1.92538224
24MP0009278_abnormal_bone_marrow1.90384663
25MP0005464_abnormal_platelet_physiology1.85869540
26MP0002398_abnormal_bone_marrow1.84183837
27MP0002166_altered_tumor_susceptibility1.81507965
28MP0003828_pulmonary_edema1.80151589
29MP0008438_abnormal_cutaneous_collagen1.77265450
30MP0001533_abnormal_skeleton_physiology1.73451763
31MP0009333_abnormal_splenocyte_physiolog1.67889107
32MP0003191_abnormal_cellular_cholesterol1.67466784
33MP0000716_abnormal_immune_system1.65080391
34MP0005058_abnormal_lysosome_morphology1.65065554
35MP0004947_skin_inflammation1.64154268
36MP0005397_hematopoietic_system_phenotyp1.63152602
37MP0001545_abnormal_hematopoietic_system1.63152602
38MP0010155_abnormal_intestine_physiology1.61430172
39MP0002877_abnormal_melanocyte_morpholog1.61245292
40MP0004808_abnormal_hematopoietic_stem1.61100621
41MP0002009_preneoplasia1.52172276
42MP0003172_abnormal_lysosome_physiology1.51356248
43MP0002722_abnormal_immune_system1.50565971
44MP0000689_abnormal_spleen_morphology1.49743781
45MP0001845_abnormal_inflammatory_respons1.48070929
46MP0003279_aneurysm1.47595656
47MP0000703_abnormal_thymus_morphology1.43613199
48MP0002429_abnormal_blood_cell1.41915368
49MP0001853_heart_inflammation1.41009375
50MP0000465_gastrointestinal_hemorrhage1.40959904
51MP0008057_abnormal_DNA_replication1.40265957
52MP0002998_abnormal_bone_remodeling1.38636778
53MP0001958_emphysema1.38049426
54MP0005451_abnormal_body_composition1.37290808
55MP0003705_abnormal_hypodermis_morpholog1.32942678
56MP0000858_altered_metastatic_potential1.27957826
57MP0003091_abnormal_cell_migration1.25542847
58MP0000343_altered_response_to1.25361375
59MP0002006_tumorigenesis1.25208885
60MP0003656_abnormal_erythrocyte_physiolo1.23638042
61MP0003448_altered_tumor_morphology1.21420758
62MP0010352_gastrointestinal_tract_polyps1.17902462
63MP0008004_abnormal_stomach_pH1.16837897
64MP0008469_abnormal_protein_level1.14816117
65MP0009764_decreased_sensitivity_to1.09256436
66MP0005310_abnormal_salivary_gland1.08914975
67MP0002132_abnormal_respiratory_system1.07967692
68MP0003075_altered_response_to1.07682221
69MP0001851_eye_inflammation1.04901261
70MP0005164_abnormal_response_to1.01042667
71MP0000604_amyloidosis1.00612843
72MP0005503_abnormal_tendon_morphology0.99767923
73MP0001873_stomach_inflammation0.96899861
74MP0002933_joint_inflammation0.96459489
75MP0005166_decreased_susceptibility_to0.95966139
76MP0003866_abnormal_defecation0.95344412
77MP0005390_skeleton_phenotype0.94954672
78MP0008260_abnormal_autophagy0.93771467
79MP0004883_abnormal_blood_vessel0.91814511
80MP0009763_increased_sensitivity_to0.90591898
81MP0003045_fibrosis0.87006464
82MP0006054_spinal_hemorrhage0.86315110
83MP0001542_abnormal_bone_strength0.82925711
84MP0005275_abnormal_skin_tensile0.82912821
85MP0000249_abnormal_blood_vessel0.82645598
86MP0005076_abnormal_cell_differentiation0.81123867
87MP0005023_abnormal_wound_healing0.80773671
88MP0002019_abnormal_tumor_incidence0.80094904
89MP0003795_abnormal_bone_structure0.76439908
90MP0010307_abnormal_tumor_latency0.73470497
91MP0000490_abnormal_crypts_of0.72336869
92MP0004185_abnormal_adipocyte_glucose0.71790722
93MP0003690_abnormal_glial_cell0.70132997
94MP0003566_abnormal_cell_adhesion0.69763165
95MP0000767_abnormal_smooth_muscle0.69033275
96MP0000015_abnormal_ear_pigmentation0.68024374
97MP0005165_increased_susceptibility_to0.67354866
98MP0003950_abnormal_plasma_membrane0.66803488
99MP0000681_abnormal_thyroid_gland0.66441544
100MP0010368_abnormal_lymphatic_system0.66254857

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.56649079
2Recurrent abscess formation (HP:0002722)4.47623455
3Recurrent bacterial skin infections (HP:0005406)4.39459658
4T lymphocytopenia (HP:0005403)3.93756894
5Recurrent viral infections (HP:0004429)3.87208635
6Spontaneous hematomas (HP:0007420)3.71392449
7Recurrent fungal infections (HP:0002841)3.67525574
8Abnormality of T cell number (HP:0011839)3.66844204
9Myositis (HP:0100614)3.59399305
10Elevated erythrocyte sedimentation rate (HP:0003565)3.54645885
11Abnormality of macrophages (HP:0004311)3.51359253
12Stomatitis (HP:0010280)3.39333478
13Panhypogammaglobulinemia (HP:0003139)3.36484073
14Abnormality of liposaccharide metabolism (HP:0010968)3.26091714
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.26091714
16Abnormality of glycolipid metabolism (HP:0010969)3.26091714
17Meningitis (HP:0001287)3.22003611
18Mediastinal lymphadenopathy (HP:0100721)3.13356275
19Cellulitis (HP:0100658)3.12852014
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.11984466
21Recurrent gram-negative bacterial infections (HP:0005420)3.07647765
22Recurrent skin infections (HP:0001581)3.00348983
23Chronic mucocutaneous candidiasis (HP:0002728)2.99447536
24Recurrent cutaneous fungal infections (HP:0011370)2.99447536
25Orchitis (HP:0100796)2.98936941
26Abnormality of T cells (HP:0002843)2.98213791
27Agammaglobulinemia (HP:0004432)2.95870481
28Autoimmune thrombocytopenia (HP:0001973)2.92482551
29Obstructive lung disease (HP:0006536)2.90738273
30Chronic obstructive pulmonary disease (HP:0006510)2.90738273
31Gingivitis (HP:0000230)2.86748069
32Granulocytopenia (HP:0001913)2.77559590
33Retrobulbar optic neuritis (HP:0100654)2.76150945
34Optic neuritis (HP:0100653)2.76150945
35Interstitial pulmonary disease (HP:0006530)2.75146078
36Abnormality of B cell number (HP:0010975)2.71364953
37B lymphocytopenia (HP:0010976)2.71114303
38Autoimmune hemolytic anemia (HP:0001890)2.70064862
39Increased cerebral lipofuscin (HP:0011813)2.66934048
40Gastrointestinal infarctions (HP:0005244)2.66192429
41Spondylolisthesis (HP:0003302)2.62028762
42Vasculitis (HP:0002633)2.58681520
43Abnormality of T cell physiology (HP:0011840)2.58306147
44Leukocytosis (HP:0001974)2.54426621
45Eosinophilia (HP:0001880)2.50626963
46Pulmonary infiltrates (HP:0002113)2.46803544
47Colitis (HP:0002583)2.45794539
48Severe combined immunodeficiency (HP:0004430)2.45064340
49Prolonged bleeding time (HP:0003010)2.41828694
50Recurrent bronchitis (HP:0002837)2.40626400
51Combined immunodeficiency (HP:0005387)2.39904433
52Increased IgE level (HP:0003212)2.38260647
53Chest pain (HP:0100749)2.38046211
54Hemoptysis (HP:0002105)2.35959751
55Epistaxis (HP:0000421)2.35379949
56Thrombocytosis (HP:0001894)2.35222463
57Dysostosis multiplex (HP:0000943)2.32929639
58Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32197389
59Encephalitis (HP:0002383)2.30227174
60Osteomyelitis (HP:0002754)2.30035185
61Keratoconjunctivitis sicca (HP:0001097)2.30023563
62Inflammation of the large intestine (HP:0002037)2.25884578
63Loss of speech (HP:0002371)2.23746147
64Gastrointestinal inflammation (HP:0004386)2.23251984
65Fatigue (HP:0012378)2.20922434
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.20503967
67Hypergammaglobulinemia (HP:0010702)2.19644976
68Abnormality of the prostate (HP:0008775)2.18714817
69Prostate neoplasm (HP:0100787)2.18444447
70Increased IgM level (HP:0003496)2.14996718
71Arterial thrombosis (HP:0004420)2.11640449
72Systemic lupus erythematosus (HP:0002725)2.10793177
73Vacuolated lymphocytes (HP:0001922)2.10169093
74Urticaria (HP:0001025)2.09900066
75Peritonitis (HP:0002586)2.07025803
76Abnormality of the peritoneum (HP:0002585)2.05459883
77Viral hepatitis (HP:0006562)2.04796844
78Keratoconjunctivitis (HP:0001096)2.04771931
79Conjunctival telangiectasia (HP:0000524)2.03694097
80Hematochezia (HP:0002573)1.99609631
81Abnormality of the fingertips (HP:0001211)1.97067203
82Hypoplasia of the thymus (HP:0000778)1.95922496
83Osteolytic defects of the phalanges of the hand (HP:0009771)1.95278362
84Osteolytic defects of the hand bones (HP:0009699)1.95278362
85Abnormality of eosinophils (HP:0001879)1.94663437
86Polycythemia (HP:0001901)1.94568521
87Dilatation of the ascending aorta (HP:0005111)1.93504067
88Myocardial infarction (HP:0001658)1.93464158
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93366243
90Glomerulopathy (HP:0100820)1.93147364
91Recurrent lower respiratory tract infections (HP:0002783)1.91524955
92Spinal cord lesions (HP:0100561)1.89071965
93Syringomyelia (HP:0003396)1.89071965
94Protrusio acetabuli (HP:0003179)1.88566795
95Purpura (HP:0000979)1.88181815
96Aortic aneurysm (HP:0004942)1.87612291
97Sepsis (HP:0100806)1.86818545
98Gingival bleeding (HP:0000225)1.84773592
99IgG deficiency (HP:0004315)1.84162560
100Chronic diarrhea (HP:0002028)1.83234845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K142.86449884
2RIPK42.83932104
3TYK22.77266483
4MAP4K12.76806696
5MAP3K132.71303783
6PRPF4B2.65098298
7MAP2K32.46841264
8ERN12.40528811
9TRIB32.29556512
10BLK2.28411748
11TESK22.22728115
12ZAP702.13290360
13FES2.09684521
14CDK121.99569019
15JAK31.89347135
16KIT1.87391410
17JAK11.86710462
18CSK1.81827485
19SMG11.77438649
20IRAK41.69800263
21TEC1.68395167
22TGFBR21.68306176
23TBK11.65323596
24TXK1.64844875
25IRAK31.64810551
26BTK1.64158894
27SYK1.54384180
28IKBKE1.46249802
29ITK1.43608883
30CAMKK21.39283844
31NEK91.33609563
32GRK61.32884855
33TRPM71.32171924
34HCK1.25584586
35MAP3K31.25395568
36EEF2K1.24107689
37SCYL21.23029736
38TAOK31.22280091
39STK101.17936602
40CDK61.17701216
41LYN1.14203842
42TTN1.12782696
43CSF1R1.10063430
44IKBKB1.08041589
45JAK21.06199912
46CDK41.06074752
47PIK3CG1.05657139
48LCK1.05168591
49GRK70.89785801
50MOS0.89718029
51MAPK110.88966856
52BMPR20.88363675
53KDR0.84339468
54KSR20.83516011
55CDC42BPA0.82154727
56HIPK20.81139367
57MAP3K10.76703652
58LRRK20.75482442
59MAPK70.74110581
60RPS6KC10.72575756
61RPS6KL10.72575756
62CAMK1D0.70669800
63TAOK20.70244987
64PDK10.69562502
65PDPK10.69521989
66MAP3K70.67503062
67CAMKK10.67337118
68IRAK10.66145693
69MELK0.65948074
70MAP3K60.65372972
71FGFR30.64178606
72MAP3K110.63408822
73MARK30.63169856
74PIM10.61952033
75TNK20.59735197
76NME20.59590689
77MAPK120.59491129
78FGFR40.57520228
79RPS6KA60.55924353
80FGR0.54165014
81CLK10.53411147
82PDGFRA0.51132961
83MARK20.50767006
84BRD40.50544357
85CAMK1G0.48479867
86NLK0.48423674
87PDGFRB0.48218900
88RAF10.47817315
89EPHB10.46001073
90MAP3K80.44448717
91MATK0.43999812
92MAPK40.41349639
93RIPK10.40865492
94MAPKAPK20.39139814
95SIK30.39134622
96RPS6KA20.38595313
97PKN20.38566866
98CDK90.38135813
99PRKCQ0.36693834
100ICK0.34059366

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.63912135
2Allograft rejection_Homo sapiens_hsa053302.55109582
3Primary immunodeficiency_Homo sapiens_hsa053402.51619154
4Osteoclast differentiation_Homo sapiens_hsa043802.38190408
5Graft-versus-host disease_Homo sapiens_hsa053322.33910034
6Autoimmune thyroid disease_Homo sapiens_hsa053202.33420944
7Staphylococcus aureus infection_Homo sapiens_hsa051502.32030600
8Asthma_Homo sapiens_hsa053102.22738503
9B cell receptor signaling pathway_Homo sapiens_hsa046622.14763501
10Other glycan degradation_Homo sapiens_hsa005112.13519777
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99492354
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.95304173
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.92196494
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91548256
15Antigen processing and presentation_Homo sapiens_hsa046121.83914161
16Measles_Homo sapiens_hsa051621.82485619
17Hematopoietic cell lineage_Homo sapiens_hsa046401.82288769
18Tuberculosis_Homo sapiens_hsa051521.80555886
19Malaria_Homo sapiens_hsa051441.75138714
20Viral myocarditis_Homo sapiens_hsa054161.73948688
21Acute myeloid leukemia_Homo sapiens_hsa052211.65178404
22Influenza A_Homo sapiens_hsa051641.64931800
23Toxoplasmosis_Homo sapiens_hsa051451.64778611
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63406083
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60523070
26Type I diabetes mellitus_Homo sapiens_hsa049401.60234251
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56319930
28T cell receptor signaling pathway_Homo sapiens_hsa046601.55301267
29Herpes simplex infection_Homo sapiens_hsa051681.54803780
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51898663
31TNF signaling pathway_Homo sapiens_hsa046681.46125814
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37395612
33Hepatitis B_Homo sapiens_hsa051611.37253832
34Pertussis_Homo sapiens_hsa051331.36791049
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36248860
36Pancreatic cancer_Homo sapiens_hsa052121.35867795
37Rheumatoid arthritis_Homo sapiens_hsa053231.35077685
38Chronic myeloid leukemia_Homo sapiens_hsa052201.34410648
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.33499881
40Lysosome_Homo sapiens_hsa041421.32504601
41Non-small cell lung cancer_Homo sapiens_hsa052231.30403620
42Legionellosis_Homo sapiens_hsa051341.28229340
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24476674
44Platelet activation_Homo sapiens_hsa046111.20803635
45Phagosome_Homo sapiens_hsa041451.18804730
46Chemokine signaling pathway_Homo sapiens_hsa040621.18255404
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16223543
48Apoptosis_Homo sapiens_hsa042101.12324827
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.10910274
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06562324
51HTLV-I infection_Homo sapiens_hsa051660.98415467
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95461491
53Hepatitis C_Homo sapiens_hsa051600.94690004
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.92264865
55African trypanosomiasis_Homo sapiens_hsa051430.91622329
56Salmonella infection_Homo sapiens_hsa051320.90000825
57Viral carcinogenesis_Homo sapiens_hsa052030.87838342
58Shigellosis_Homo sapiens_hsa051310.87737299
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85917551
60Bladder cancer_Homo sapiens_hsa052190.82999116
61Renal cell carcinoma_Homo sapiens_hsa052110.81076525
62Epstein-Barr virus infection_Homo sapiens_hsa051690.80175733
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79993703
64VEGF signaling pathway_Homo sapiens_hsa043700.78913202
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.77162914
66Systemic lupus erythematosus_Homo sapiens_hsa053220.73985534
67Prolactin signaling pathway_Homo sapiens_hsa049170.73923331
68Amoebiasis_Homo sapiens_hsa051460.73252822
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71242813
70Small cell lung cancer_Homo sapiens_hsa052220.64076266
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.63327938
72mTOR signaling pathway_Homo sapiens_hsa041500.59967647
73DNA replication_Homo sapiens_hsa030300.59815628
74FoxO signaling pathway_Homo sapiens_hsa040680.57661790
75HIF-1 signaling pathway_Homo sapiens_hsa040660.54045699
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.53792813
77Prostate cancer_Homo sapiens_hsa052150.53462053
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.49818608
79Colorectal cancer_Homo sapiens_hsa052100.45286136
80Glioma_Homo sapiens_hsa052140.44685796
81Prion diseases_Homo sapiens_hsa050200.42097153
82Notch signaling pathway_Homo sapiens_hsa043300.41555975
83Proteoglycans in cancer_Homo sapiens_hsa052050.41277067
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41021726
85Endocytosis_Homo sapiens_hsa041440.40103176
86MicroRNAs in cancer_Homo sapiens_hsa052060.40032455
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39738821
88Choline metabolism in cancer_Homo sapiens_hsa052310.37381263
89Focal adhesion_Homo sapiens_hsa045100.36756326
90Dorso-ventral axis formation_Homo sapiens_hsa043200.36560526
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36230794
92GnRH signaling pathway_Homo sapiens_hsa049120.35687821
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34640564
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34206115
95Insulin resistance_Homo sapiens_hsa049310.34085011
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32537964
97Inositol phosphate metabolism_Homo sapiens_hsa005620.30501951
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29603617
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29072010
100Endometrial cancer_Homo sapiens_hsa052130.28520336

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