SLFN12L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)4.80747564
2regulation of B cell receptor signaling pathway (GO:0050855)4.46872123
3negative T cell selection (GO:0043383)4.21446508
4positive regulation of gamma-delta T cell activation (GO:0046645)4.16298842
5indolalkylamine metabolic process (GO:0006586)3.98420186
6negative thymic T cell selection (GO:0045060)3.91091536
7interferon-gamma production (GO:0032609)3.90911182
8cellular response to interleukin-15 (GO:0071350)3.85915571
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.84065841
10neural tube formation (GO:0001841)3.81097170
11negative regulation of cell killing (GO:0031342)3.70731624
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.70731624
13protein K11-linked deubiquitination (GO:0035871)3.60867023
14regulation of gamma-delta T cell differentiation (GO:0045586)3.56204523
15positive T cell selection (GO:0043368)3.54500552
16establishment of protein localization to Golgi (GO:0072600)3.53753281
17indole-containing compound catabolic process (GO:0042436)3.50670891
18indolalkylamine catabolic process (GO:0046218)3.50670891
19tryptophan catabolic process (GO:0006569)3.50670891
20monoubiquitinated protein deubiquitination (GO:0035520)3.45488464
21response to interleukin-15 (GO:0070672)3.41139588
22DNA deamination (GO:0045006)3.36734129
23regulation of gamma-delta T cell activation (GO:0046643)3.36092062
24serotonin metabolic process (GO:0042428)3.35285047
25phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29204140
26kynurenine metabolic process (GO:0070189)3.28321314
27positive regulation of granulocyte differentiation (GO:0030854)3.24036606
28fucose catabolic process (GO:0019317)3.23180723
29L-fucose metabolic process (GO:0042354)3.23180723
30L-fucose catabolic process (GO:0042355)3.23180723
31behavioral response to nicotine (GO:0035095)3.17822579
32primary amino compound metabolic process (GO:1901160)3.16369535
33negative regulation of T cell mediated immunity (GO:0002710)3.11102428
34tryptophan metabolic process (GO:0006568)3.08443192
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07043977
36indole-containing compound metabolic process (GO:0042430)3.04247600
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.03404709
38positive regulation of developmental pigmentation (GO:0048087)3.01602999
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98630948
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98127139
41detection of light stimulus involved in sensory perception (GO:0050962)2.95782665
42detection of light stimulus involved in visual perception (GO:0050908)2.95782665
43cilium or flagellum-dependent cell motility (GO:0001539)2.94315358
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93209131
45histone H3-K4 trimethylation (GO:0080182)2.92924303
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92708267
47signal peptide processing (GO:0006465)2.89114959
48positive regulation of defense response to virus by host (GO:0002230)2.87240214
49regulation of regulatory T cell differentiation (GO:0045589)2.83578176
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82280849
51negative regulation of translation, ncRNA-mediated (GO:0040033)2.82280849
52regulation of translation, ncRNA-mediated (GO:0045974)2.82280849
53protein targeting to Golgi (GO:0000042)2.81021872
54protein K63-linked deubiquitination (GO:0070536)2.79247927
55photoreceptor cell maintenance (GO:0045494)2.78928521
56T cell selection (GO:0045058)2.78222192
57antigen processing and presentation of endogenous antigen (GO:0019883)2.78070529
58protein K48-linked deubiquitination (GO:0071108)2.73792558
59regulation of alpha-beta T cell proliferation (GO:0046640)2.73622188
60T cell migration (GO:0072678)2.68710213
61regulation of isotype switching to IgG isotypes (GO:0048302)2.68180338
62adaptation of signaling pathway (GO:0023058)2.68040982
63cAMP catabolic process (GO:0006198)2.67399477
64negative regulation of lymphocyte mediated immunity (GO:0002707)2.63314840
65axoneme assembly (GO:0035082)2.63251985
66hepatocyte apoptotic process (GO:0097284)2.63094661
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63032327
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.62311321
69cellular response to ethanol (GO:0071361)2.62181740
70rRNA catabolic process (GO:0016075)2.62056830
71histone mRNA catabolic process (GO:0071044)2.61805449
72positive regulation of alpha-beta T cell proliferation (GO:0046641)2.61254506
73histone H3-K9 methylation (GO:0051567)2.61088636
74tachykinin receptor signaling pathway (GO:0007217)2.59096953
75negative regulation of cAMP-mediated signaling (GO:0043951)2.58095075
76alpha-beta T cell differentiation (GO:0046632)2.58017795
77regulation of MHC class I biosynthetic process (GO:0045343)2.57168563
78response to pheromone (GO:0019236)2.55723117
79negative regulation of mast cell activation (GO:0033004)2.52263106
80mast cell activation (GO:0045576)2.51720844
81cytokine biosynthetic process (GO:0042089)2.51084329
82retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51027372
83negative regulation of calcium ion transport into cytosol (GO:0010523)2.49031994
84negative regulation of adaptive immune response (GO:0002820)2.48622409
85mast cell degranulation (GO:0043303)2.47987581
86mast cell activation involved in immune response (GO:0002279)2.47987581
87B cell receptor signaling pathway (GO:0050853)2.47632687
88histone H3-K9 modification (GO:0061647)2.47075416
89regulation of pigment cell differentiation (GO:0050932)2.46923958
90snRNA transcription (GO:0009301)2.46477475
91positive thymic T cell selection (GO:0045059)2.45306311
92reflex (GO:0060004)2.41516623
93cyclic nucleotide catabolic process (GO:0009214)2.39908805
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39535815
95retinal cone cell development (GO:0046549)2.38791924
96alpha-beta T cell activation (GO:0046631)2.35762507
97dopamine transport (GO:0015872)2.35698130
98tolerance induction (GO:0002507)2.35536274
99reciprocal meiotic recombination (GO:0007131)2.31884670
100reciprocal DNA recombination (GO:0035825)2.31884670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16323708
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.93214794
3VDR_22108803_ChIP-Seq_LS180_Human2.80620199
4GBX2_23144817_ChIP-Seq_PC3_Human2.79628977
5ZNF274_21170338_ChIP-Seq_K562_Hela2.75104005
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70928615
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47967882
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43996551
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43276784
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.35651251
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31028890
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30392109
13IGF1R_20145208_ChIP-Seq_DFB_Human2.28206537
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26132028
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16506420
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90875125
17ER_23166858_ChIP-Seq_MCF-7_Human1.89386844
18RUNX_20019798_ChIP-Seq_JUKART_Human1.87981517
19TAF15_26573619_Chip-Seq_HEK293_Human1.87331089
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86263647
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.82997147
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78715162
23EZH2_22144423_ChIP-Seq_EOC_Human1.77918294
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.76919328
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75554120
26P300_19829295_ChIP-Seq_ESCs_Human1.72358496
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.70447048
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69742027
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.67447551
30STAT3_23295773_ChIP-Seq_U87_Human1.67426866
31BCAT_22108803_ChIP-Seq_LS180_Human1.65484967
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65358076
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62469046
34EWS_26573619_Chip-Seq_HEK293_Human1.60199323
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58463187
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55017575
37FUS_26573619_Chip-Seq_HEK293_Human1.53107388
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52658599
39TCF4_23295773_ChIP-Seq_U87_Human1.50649663
40PRDM14_20953172_ChIP-Seq_ESCs_Human1.47665736
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46035921
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46029702
43SMAD4_21799915_ChIP-Seq_A2780_Human1.44527325
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43842401
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43842401
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41429997
47CBP_20019798_ChIP-Seq_JUKART_Human1.41429997
48* GATA3_26560356_Chip-Seq_TH2_Human1.40380858
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.38330245
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36539459
51AR_21572438_ChIP-Seq_LNCaP_Human1.35701077
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.35312132
53MYB_26560356_Chip-Seq_TH2_Human1.32838948
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30415671
55CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29405960
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.28114681
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.27764856
58AR_25329375_ChIP-Seq_VCAP_Human1.27762279
59TCF4_22108803_ChIP-Seq_LS180_Human1.23548255
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22080801
61GATA3_27048872_Chip-Seq_THYMUS_Human1.21934242
62IRF1_19129219_ChIP-ChIP_H3396_Human1.20765208
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19283506
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18436010
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18373187
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.18125825
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17943259
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17578152
69TP53_16413492_ChIP-PET_HCT116_Human1.17534923
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15683422
71* TP53_22573176_ChIP-Seq_HFKS_Human1.15199005
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.14071051
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13826860
74RUNX2_22187159_ChIP-Seq_PCA_Human1.12989075
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12797962
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10810836
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10179298
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10153914
79SMRT_27268052_Chip-Seq_Bcells_Human1.09367319
80SOX2_19829295_ChIP-Seq_ESCs_Human1.08987253
81NANOG_19829295_ChIP-Seq_ESCs_Human1.08987253
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.08222144
83P53_22387025_ChIP-Seq_ESCs_Mouse1.06592085
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06587385
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05252603
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05174017
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04920175
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04005713
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03985022
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.03906500
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03906500
92VDR_24787735_ChIP-Seq_THP-1_Human1.03409649
93* SMAD4_21741376_ChIP-Seq_EPCs_Human1.02793979
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02456082
95CDX2_22108803_ChIP-Seq_LS180_Human1.02005364
96* DROSHA_22980978_ChIP-Seq_HELA_Human1.01907994
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01329633
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.00804126
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00284937
100KDM2B_26808549_Chip-Seq_REH_Human0.99970558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.90155798
2MP0003787_abnormal_imprinting3.46803935
3MP0005671_abnormal_response_to3.07693561
4MP0008877_abnormal_DNA_methylation3.07650717
5MP0003763_abnormal_thymus_physiology2.90058670
6MP0008057_abnormal_DNA_replication2.66354132
7MP0003195_calcinosis2.44117148
8MP0001835_abnormal_antigen_presentation2.29706339
9MP0001800_abnormal_humoral_immune2.28666565
10MP0001501_abnormal_sleep_pattern2.10379569
11MP0003646_muscle_fatigue2.07743426
12MP0005075_abnormal_melanosome_morpholog1.95650491
13MP0005551_abnormal_eye_electrophysiolog1.94499537
14MP0003724_increased_susceptibility_to1.87768447
15MP0000427_abnormal_hair_cycle1.78822018
16MP0002102_abnormal_ear_morphology1.77521381
17MP0004043_abnormal_pH_regulation1.71164290
18MP0005174_abnormal_tail_pigmentation1.70975291
19MP0002723_abnormal_immune_serum1.69968337
20MP0001790_abnormal_immune_system1.64486967
21MP0005387_immune_system_phenotype1.64486967
22MP0005310_abnormal_salivary_gland1.62965811
23MP0000685_abnormal_immune_system1.62874715
24MP0001968_abnormal_touch/_nociception1.61720293
25MP0004142_abnormal_muscle_tone1.61464546
26MP0004381_abnormal_hair_follicle1.57380349
27MP0002420_abnormal_adaptive_immunity1.56376624
28MP0001986_abnormal_taste_sensitivity1.55952797
29MP0001819_abnormal_immune_cell1.52962286
30MP0002452_abnormal_antigen_presenting1.48384439
31MP0000015_abnormal_ear_pigmentation1.46564033
32MP0001873_stomach_inflammation1.44378108
33MP0000372_irregular_coat_pigmentation1.43780783
34MP0005000_abnormal_immune_tolerance1.43711012
35MP0002736_abnormal_nociception_after1.38503307
36MP0006276_abnormal_autonomic_nervous1.37110259
37MP0009745_abnormal_behavioral_response1.36088737
38MP0003045_fibrosis1.34349744
39MP0006082_CNS_inflammation1.32275779
40MP0008872_abnormal_physiological_respon1.32064653
41MP0005645_abnormal_hypothalamus_physiol1.31005385
42MP0009046_muscle_twitch1.27711171
43MP0000689_abnormal_spleen_morphology1.25842021
44MP0002876_abnormal_thyroid_physiology1.25347778
45MP0005253_abnormal_eye_physiology1.24423683
46MP0002138_abnormal_hepatobiliary_system1.23976475
47MP0000703_abnormal_thymus_morphology1.23967428
48MP0000716_abnormal_immune_system1.23871298
49MP0002398_abnormal_bone_marrow1.21145819
50MP0009785_altered_susceptibility_to1.19723701
51MP0003866_abnormal_defecation1.19353409
52MP0002405_respiratory_system_inflammati1.17187172
53MP0002163_abnormal_gland_morphology1.15374579
54MP0002928_abnormal_bile_duct1.12776628
55MP0005025_abnormal_response_to1.10719470
56MP0002095_abnormal_skin_pigmentation1.07264976
57MP0001485_abnormal_pinna_reflex1.06005439
58MP0002693_abnormal_pancreas_physiology1.05243333
59MP0002837_dystrophic_cardiac_calcinosis1.04177718
60MP0002148_abnormal_hypersensitivity_rea1.01631298
61MP0005386_behavior/neurological_phenoty1.01309204
62MP0004924_abnormal_behavior1.01309204
63MP0004742_abnormal_vestibular_system1.00755592
64MP0006072_abnormal_retinal_apoptosis0.99755331
65MP0002722_abnormal_immune_system0.98349109
66MP0004130_abnormal_muscle_cell0.98251995
67MP0005379_endocrine/exocrine_gland_phen0.97528424
68MP0001486_abnormal_startle_reflex0.95277787
69MP0003121_genomic_imprinting0.94972376
70MP0002277_abnormal_respiratory_mucosa0.94938926
71MP0009764_decreased_sensitivity_to0.94486422
72MP0002419_abnormal_innate_immunity0.94409677
73MP0003880_abnormal_central_pattern0.94400857
74MP0005389_reproductive_system_phenotype0.93666807
75MP0002272_abnormal_nervous_system0.92483969
76MP0001919_abnormal_reproductive_system0.91552718
77MP0000371_diluted_coat_color0.90046365
78MP0008961_abnormal_basal_metabolism0.88188366
79MP0002166_altered_tumor_susceptibility0.85881249
80MP0002572_abnormal_emotion/affect_behav0.84924713
81MP0002067_abnormal_sensory_capabilities0.84887263
82MP0002064_seizures0.84238775
83MP0002429_abnormal_blood_cell0.81468151
84MP0001984_abnormal_olfaction0.81301037
85MP0005266_abnormal_metabolism0.80461184
86MP0002168_other_aberrant_phenotype0.79805690
87MP0004147_increased_porphyrin_level0.78264597
88MP0003252_abnormal_bile_duct0.77210678
89MP0009333_abnormal_splenocyte_physiolog0.77141908
90MP0000230_abnormal_systemic_arterial0.76912364
91MP0001845_abnormal_inflammatory_respons0.76674388
92MP0002229_neurodegeneration0.76618242
93MP0001970_abnormal_pain_threshold0.75524609
94MP0002638_abnormal_pupillary_reflex0.75312631
95MP0005167_abnormal_blood-brain_barrier0.75022989
96MP0006054_spinal_hemorrhage0.74738247
97MP0002735_abnormal_chemical_nociception0.74245676
98MP0008995_early_reproductive_senescence0.74115551
99MP0000631_abnormal_neuroendocrine_gland0.74011859
100MP0005646_abnormal_pituitary_gland0.73941940

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.24827829
2Abnormality of T cell number (HP:0011839)3.78833671
3T lymphocytopenia (HP:0005403)3.78529942
4Pancreatic fibrosis (HP:0100732)3.61454434
5Hyperventilation (HP:0002883)3.59884099
6Abnormality of midbrain morphology (HP:0002418)3.46165627
7Molar tooth sign on MRI (HP:0002419)3.46165627
8Genetic anticipation (HP:0003743)3.45366374
9Stomatitis (HP:0010280)3.42582783
10True hermaphroditism (HP:0010459)3.37851353
11Congenital stationary night blindness (HP:0007642)3.33180240
12Abnormality of the renal cortex (HP:0011035)3.16013122
13Gaze-evoked nystagmus (HP:0000640)3.13067755
14Attenuation of retinal blood vessels (HP:0007843)3.04389491
15Stomach cancer (HP:0012126)2.95230809
16Thyroiditis (HP:0100646)2.94784355
17IgG deficiency (HP:0004315)2.92705724
18Progressive cerebellar ataxia (HP:0002073)2.84759349
19Severe combined immunodeficiency (HP:0004430)2.84382480
20Abnormality of T cells (HP:0002843)2.81045969
21Nephronophthisis (HP:0000090)2.79682599
22Protruding tongue (HP:0010808)2.77668937
23Chronic hepatic failure (HP:0100626)2.76754027
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.73516845
25Abnormality of the renal medulla (HP:0100957)2.67922883
26Absent speech (HP:0001344)2.57793720
27Panhypogammaglobulinemia (HP:0003139)2.57442197
28Clumsiness (HP:0002312)2.57413530
29Cystic liver disease (HP:0006706)2.54025713
30Progressive inability to walk (HP:0002505)2.49042970
31Elevated erythrocyte sedimentation rate (HP:0003565)2.47926009
32Abnormality of eosinophils (HP:0001879)2.45972054
33Febrile seizures (HP:0002373)2.44735389
34Recurrent fungal infections (HP:0002841)2.43441089
35Abolished electroretinogram (ERG) (HP:0000550)2.39931758
36Type II lissencephaly (HP:0007260)2.39874992
37Medial flaring of the eyebrow (HP:0010747)2.39120747
38Renal cortical cysts (HP:0000803)2.38331579
39Fair hair (HP:0002286)2.37487420
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34307071
41Abnormality of B cell number (HP:0010975)2.31868084
42Widely spaced teeth (HP:0000687)2.30212178
43Chronic mucocutaneous candidiasis (HP:0002728)2.28778955
44Recurrent cutaneous fungal infections (HP:0011370)2.28778955
45Inability to walk (HP:0002540)2.27262303
46Recurrent bronchitis (HP:0002837)2.24520657
47Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23064704
48Encephalitis (HP:0002383)2.21457966
49Optic neuritis (HP:0100653)2.19778687
50Retrobulbar optic neuritis (HP:0100654)2.19778687
51Abnormal rod and cone electroretinograms (HP:0008323)2.18398226
52Abnormal drinking behavior (HP:0030082)2.16264582
53Polydipsia (HP:0001959)2.16264582
54Eosinophilia (HP:0001880)2.14948789
55Hypochromic microcytic anemia (HP:0004840)2.11603866
56Autoimmune hemolytic anemia (HP:0001890)2.10606723
57Pustule (HP:0200039)2.05393636
58Hypoproteinemia (HP:0003075)2.04659362
59Tubular atrophy (HP:0000092)2.00515141
60Abnormality of T cell physiology (HP:0011840)2.00313120
61Decreased circulating renin level (HP:0003351)1.99027836
62Absent/shortened dynein arms (HP:0200106)1.98034854
63Dynein arm defect of respiratory motile cilia (HP:0012255)1.98034854
64Myositis (HP:0100614)1.96546770
65Broad-based gait (HP:0002136)1.96536000
66Volvulus (HP:0002580)1.95809053
67Generalized hypopigmentation of hair (HP:0011358)1.95536686
68Leukocytosis (HP:0001974)1.95191625
69Chronic diarrhea (HP:0002028)1.94506211
70Increased neuronal autofluorescent lipopigment (HP:0002074)1.94258525
71Bony spicule pigmentary retinopathy (HP:0007737)1.89678729
72Focal seizures (HP:0007359)1.89581835
73Furrowed tongue (HP:0000221)1.87082739
74Congenital hepatic fibrosis (HP:0002612)1.85449280
75Gait imbalance (HP:0002141)1.85074501
76Dialeptic seizures (HP:0011146)1.84341693
77Congenital primary aphakia (HP:0007707)1.83791318
78Recurrent bacterial skin infections (HP:0005406)1.83477166
79Tented upper lip vermilion (HP:0010804)1.82758992
80Combined immunodeficiency (HP:0005387)1.82624802
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.82582630
82Hemiplegia (HP:0002301)1.82213993
83Constricted visual fields (HP:0001133)1.81093546
84Abnormal biliary tract physiology (HP:0012439)1.79815202
85Bile duct proliferation (HP:0001408)1.79815202
86Large for gestational age (HP:0001520)1.78676055
87Anencephaly (HP:0002323)1.77855076
88Hypoplasia of the thymus (HP:0000778)1.77274594
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.76566610
90Congenital sensorineural hearing impairment (HP:0008527)1.76111096
91Decreased central vision (HP:0007663)1.75333867
92Lissencephaly (HP:0001339)1.74543573
93Increased corneal curvature (HP:0100692)1.71084738
94Keratoconus (HP:0000563)1.71084738
95Nephrogenic diabetes insipidus (HP:0009806)1.70830738
96Keratoconjunctivitis (HP:0001096)1.70577364
97Pendular nystagmus (HP:0012043)1.69601945
98Hypochromic anemia (HP:0001931)1.68779265
99Polyuria (HP:0000103)1.68350443
100Orchitis (HP:0100796)1.68290077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.25861802
2ACVR1B3.85753718
3TXK3.71248898
4TAOK32.91115359
5BMPR1B2.15378664
6NUAK12.13887848
7MAP4K12.10771925
8ADRBK22.04351099
9MAP4K22.01277535
10TEC1.94495759
11MAPK131.74464788
12ITK1.73357121
13WNK31.68825373
14CAMKK21.66362913
15INSRR1.53617741
16PINK11.47245262
17GRK11.43455498
18CASK1.43194099
19PIK3CG1.35710020
20TNIK1.28338076
21FES1.28040592
22BTK1.25385773
23IKBKE1.23750608
24NLK1.23502375
25JAK11.22850985
26SYK1.22449484
27TNK21.20811265
28MARK31.19778246
29PAK31.15595093
30TYK21.14375101
31PTK2B1.05334046
32JAK31.01172394
33PRKCQ0.98949788
34LCK0.97851332
35OXSR10.97421722
36MAP3K40.93833854
37WNK40.93635287
38ZAK0.93502675
39ADRBK10.91627699
40IRAK10.91421142
41IKBKB0.91195899
42BLK0.87959186
43GRK60.87496449
44KIT0.87210038
45SIK20.86720817
46MKNK20.82319716
47AKT30.81121631
48TLK10.80408036
49LYN0.79192327
50HCK0.76037412
51SGK20.75182109
52CSK0.72099821
53TRIM280.71884508
54NTRK30.70884395
55DAPK20.69888583
56RIPK40.68896716
57STK390.68195528
58MST40.68007253
59MAP2K60.66158931
60PIK3CA0.63801530
61HIPK20.59117288
62STK110.59012256
63PIM10.58600105
64FGFR20.57428755
65GRK70.56028390
66STK380.55293511
67CAMKK10.54684438
68MAP3K70.54617303
69PRKCE0.53107448
70TRPM70.52277030
71PRKCH0.52079886
72CHUK0.49903954
73CAMK40.49369306
74FGFR30.48443547
75NTRK20.48157884
76IRAK40.47220567
77STK38L0.47060582
78TGFBR10.46482003
79WNK10.45270547
80EPHA30.45203993
81GRK50.45117459
82ZAP700.44866367
83PRKAA20.42932141
84JAK20.41023979
85MAPKAPK30.40913924
86PDK10.40691686
87BCR0.40690222
88CAMK10.39565278
89MUSK0.39004149
90DYRK1A0.37304705
91TYRO30.37267791
92MELK0.35728523
93ABL10.34922624
94ERBB30.34812064
95CAMK2A0.34417790
96MAPK110.33816119
97CSNK1D0.33677324
98ERBB20.33444456
99MAP3K140.33268289
100RPS6KA50.32489249

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.57857088
2Graft-versus-host disease_Homo sapiens_hsa053322.49813313
3Phototransduction_Homo sapiens_hsa047442.18570331
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.09831737
5Linoleic acid metabolism_Homo sapiens_hsa005912.05192329
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05081799
7Autoimmune thyroid disease_Homo sapiens_hsa053202.02229543
8Allograft rejection_Homo sapiens_hsa053301.99527248
9T cell receptor signaling pathway_Homo sapiens_hsa046601.95400304
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89472021
11ABC transporters_Homo sapiens_hsa020101.83467014
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77211804
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76030897
14Nitrogen metabolism_Homo sapiens_hsa009101.71592163
15Type I diabetes mellitus_Homo sapiens_hsa049401.62859694
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52988767
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51812338
18Nicotine addiction_Homo sapiens_hsa050331.51560644
19Butanoate metabolism_Homo sapiens_hsa006501.48500572
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48348286
21Ether lipid metabolism_Homo sapiens_hsa005651.47020349
22Tryptophan metabolism_Homo sapiens_hsa003801.44445591
23Asthma_Homo sapiens_hsa053101.38977348
24Morphine addiction_Homo sapiens_hsa050321.32946711
25Dorso-ventral axis formation_Homo sapiens_hsa043201.32450300
26Olfactory transduction_Homo sapiens_hsa047401.31483489
27Taste transduction_Homo sapiens_hsa047421.28708842
28Hematopoietic cell lineage_Homo sapiens_hsa046401.28645649
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.27459592
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25770875
31Homologous recombination_Homo sapiens_hsa034401.24630346
32Regulation of autophagy_Homo sapiens_hsa041401.23736740
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23394328
34Measles_Homo sapiens_hsa051621.21700911
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19070361
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17073953
37Antigen processing and presentation_Homo sapiens_hsa046121.17061371
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15452796
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.12503735
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07606544
41Caffeine metabolism_Homo sapiens_hsa002321.04721570
42Selenocompound metabolism_Homo sapiens_hsa004501.00194684
43Glycerolipid metabolism_Homo sapiens_hsa005610.99376539
44Fanconi anemia pathway_Homo sapiens_hsa034600.97507086
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.96160192
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95672807
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93219872
48Serotonergic synapse_Homo sapiens_hsa047260.89695111
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87361815
50Calcium signaling pathway_Homo sapiens_hsa040200.87156515
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86060354
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.84743434
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83816566
54Glutamatergic synapse_Homo sapiens_hsa047240.82638509
55Circadian entrainment_Homo sapiens_hsa047130.82278240
56B cell receptor signaling pathway_Homo sapiens_hsa046620.80910428
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.80679131
58Platelet activation_Homo sapiens_hsa046110.80144747
59Salivary secretion_Homo sapiens_hsa049700.78057214
60Osteoclast differentiation_Homo sapiens_hsa043800.77646755
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77373131
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76973893
63Staphylococcus aureus infection_Homo sapiens_hsa051500.76213920
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.75418836
65Circadian rhythm_Homo sapiens_hsa047100.74880307
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74590288
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74453770
68Basal transcription factors_Homo sapiens_hsa030220.74433568
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.74284870
70Chemokine signaling pathway_Homo sapiens_hsa040620.73424033
71Propanoate metabolism_Homo sapiens_hsa006400.68060830
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67276028
73Ovarian steroidogenesis_Homo sapiens_hsa049130.65374999
74GABAergic synapse_Homo sapiens_hsa047270.65334736
75Chemical carcinogenesis_Homo sapiens_hsa052040.65106497
76RNA degradation_Homo sapiens_hsa030180.63369828
77Insulin secretion_Homo sapiens_hsa049110.63335636
78Arachidonic acid metabolism_Homo sapiens_hsa005900.61952936
79Tuberculosis_Homo sapiens_hsa051520.61596595
80Leishmaniasis_Homo sapiens_hsa051400.61247249
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60805466
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60187509
83Cholinergic synapse_Homo sapiens_hsa047250.59375932
84Oxytocin signaling pathway_Homo sapiens_hsa049210.59356664
85FoxO signaling pathway_Homo sapiens_hsa040680.58967275
86Herpes simplex infection_Homo sapiens_hsa051680.58482192
87Rheumatoid arthritis_Homo sapiens_hsa053230.57423318
88Non-homologous end-joining_Homo sapiens_hsa034500.57084547
89Retinol metabolism_Homo sapiens_hsa008300.56320838
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54701826
91Peroxisome_Homo sapiens_hsa041460.53417783
92Renin secretion_Homo sapiens_hsa049240.52265168
93cAMP signaling pathway_Homo sapiens_hsa040240.51449029
94Long-term depression_Homo sapiens_hsa047300.50101512
95TNF signaling pathway_Homo sapiens_hsa046680.47329012
96Lysine degradation_Homo sapiens_hsa003100.46741347
97African trypanosomiasis_Homo sapiens_hsa051430.46487047
98RNA polymerase_Homo sapiens_hsa030200.45134237
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45074148
100Viral myocarditis_Homo sapiens_hsa054160.44127317

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