SLFNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.61292443
2motile cilium assembly (GO:0044458)9.47402021
3epithelial cilium movement (GO:0003351)9.34986234
4axonemal dynein complex assembly (GO:0070286)9.20366176
5reproduction (GO:0000003)9.05587273
6rRNA modification (GO:0000154)8.96432268
7cellular response to ATP (GO:0071318)8.78179731
8regulation of cilium movement (GO:0003352)8.60732961
9negative regulation of inclusion body assembly (GO:0090084)8.03831618
10meiotic chromosome segregation (GO:0045132)7.63144833
11cilium movement (GO:0003341)7.43145650
12DNA strand renaturation (GO:0000733)7.32393469
13cilium or flagellum-dependent cell motility (GO:0001539)7.27891055
14organic cation transport (GO:0015695)7.22699051
15sperm capacitation (GO:0048240)7.16288619
16spermatogenesis (GO:0007283)7.09986301
17male gamete generation (GO:0048232)7.07351249
18single fertilization (GO:0007338)7.04529131
19synaptonemal complex organization (GO:0070193)6.87047838
20microtubule depolymerization (GO:0007019)6.85296604
21adenosine receptor signaling pathway (GO:0001973)6.85117243
22GDP-mannose metabolic process (GO:0019673)6.84126969
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.79477157
24synaptonemal complex assembly (GO:0007130)6.79345001
25regulation of inclusion body assembly (GO:0090083)6.61047279
26gamete generation (GO:0007276)6.49705901
27chromosome condensation (GO:0030261)6.40821849
28male meiosis (GO:0007140)6.38368220
29positive regulation of protein kinase C signaling (GO:0090037)6.24558343
30negative regulation of cell aging (GO:0090344)6.19354462
31piRNA metabolic process (GO:0034587)6.17671787
32purinergic nucleotide receptor signaling pathway (GO:0035590)6.10552850
33DNA packaging (GO:0006323)6.05380250
34fertilization (GO:0009566)6.04990016
35urinary tract smooth muscle contraction (GO:0014848)5.99703014
36calcium ion-dependent exocytosis (GO:0017156)5.95923984
37adenine nucleotide transport (GO:0051503)5.91557590
38G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.90431354
39purine ribonucleotide transport (GO:0015868)5.88925534
40spermatid nucleus differentiation (GO:0007289)5.52067596
41germ cell development (GO:0007281)5.50400530
42glycerol ether metabolic process (GO:0006662)5.40837563
43cellular process involved in reproduction in multicellular organism (GO:0022412)5.38813200
44sensory perception of taste (GO:0050909)5.36657191
45phosphatidylethanolamine biosynthetic process (GO:0006646)5.18549347
46peristalsis (GO:0030432)5.18410190
47multicellular organismal reproductive process (GO:0048609)5.10437541
48regulation of microtubule-based movement (GO:0060632)5.09041318
49cell recognition (GO:0008037)5.08571844
50lens fiber cell differentiation (GO:0070306)5.03580108
51sexual reproduction (GO:0019953)4.99748269
52ether metabolic process (GO:0018904)4.99737486
53nucleotide transmembrane transport (GO:1901679)4.94681739
54regulation of protein kinase A signaling (GO:0010738)4.91551970
55nucleoside transmembrane transport (GO:1901642)4.91085131
56response to ATP (GO:0033198)4.87694319
57microtubule severing (GO:0051013)4.83980348
58ventricular system development (GO:0021591)4.83442546
59sex determination (GO:0007530)4.80672317
60purine nucleotide transport (GO:0015865)4.71482167
61seminiferous tubule development (GO:0072520)4.67553983
62phosphatidylethanolamine metabolic process (GO:0046337)4.65659642
63single strand break repair (GO:0000012)4.60140518
64chromosome organization involved in meiosis (GO:0070192)4.50649484
65UV protection (GO:0009650)4.49836215
66purinergic receptor signaling pathway (GO:0035587)4.48490146
67regulation of skeletal muscle contraction (GO:0014819)4.45531909
68male meiosis I (GO:0007141)4.43459509
69chaperone-mediated protein complex assembly (GO:0051131)4.42664254
70DNA replication checkpoint (GO:0000076)4.34766271
71histone phosphorylation (GO:0016572)4.34098455
72melanin biosynthetic process (GO:0042438)4.30787984
73left/right pattern formation (GO:0060972)4.25623654
74multicellular organismal development (GO:0007275)4.12944848
75behavioral response to nicotine (GO:0035095)4.06678396
76DNA methylation involved in gamete generation (GO:0043046)4.00999819
77sequestering of actin monomers (GO:0042989)3.98930935
78melanin metabolic process (GO:0006582)3.97899625
79meiotic nuclear division (GO:0007126)3.87165324
80sialylation (GO:0097503)3.86558256
81centriole assembly (GO:0098534)3.86557108
82gonadal mesoderm development (GO:0007506)3.85444626
83neuromuscular synaptic transmission (GO:0007274)3.85126142
84negative regulation of Rho protein signal transduction (GO:0035024)3.83523977
85cranial nerve morphogenesis (GO:0021602)3.78809370
86response to pheromone (GO:0019236)3.78272412
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.74794116
88urogenital system development (GO:0001655)3.73407983
89multicellular organismal movement (GO:0050879)3.68730925
90musculoskeletal movement (GO:0050881)3.68730925
91grooming behavior (GO:0007625)3.56773121
92RNA methylation (GO:0001510)3.56630849
93regulation of nuclear cell cycle DNA replication (GO:0033262)3.55629831
94G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.54882858
95tRNA modification (GO:0006400)3.53263397
96regulation of spindle checkpoint (GO:0090231)3.52937687
97microtubule polymerization or depolymerization (GO:0031109)3.51839645
98meiosis I (GO:0007127)3.51524976
99purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.51237756
1003-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.51237756
101secondary metabolite biosynthetic process (GO:0044550)3.48519909
102protein K11-linked deubiquitination (GO:0035871)3.47853879
103protein polyglutamylation (GO:0018095)3.43612131
104positive regulation of catecholamine secretion (GO:0033605)3.41153721
105protein refolding (GO:0042026)3.37451506
106positive regulation of macrophage activation (GO:0043032)3.35652211
107nucleoside transport (GO:0015858)3.31804770
108genitalia morphogenesis (GO:0035112)3.30756843
109interferon-gamma secretion (GO:0072643)3.26184402
110cellular ketone body metabolic process (GO:0046950)3.24688193
111polyamine biosynthetic process (GO:0006596)3.24152043
112nucleotide-sugar biosynthetic process (GO:0009226)3.23475910
113regulation of Rab GTPase activity (GO:0032313)3.22827601
114positive regulation of Rab GTPase activity (GO:0032851)3.22827601
115RNA destabilization (GO:0050779)3.22262379
116nucleus organization (GO:0006997)3.21909006
117glycolytic process (GO:0006096)3.18360227
118amino-acid betaine transport (GO:0015838)3.17889498
119carnitine transport (GO:0015879)3.17889498
120regulation of synapse structural plasticity (GO:0051823)3.17127014
121protein localization to Golgi apparatus (GO:0034067)3.16484536
122establishment of protein localization to Golgi (GO:0072600)3.15128176
123RNA localization (GO:0006403)3.14852476
124purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.14117031
125ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.14117031
126nucleoside bisphosphate biosynthetic process (GO:0033866)3.14117031
127mitotic sister chromatid cohesion (GO:0007064)3.13663724
128chromatin silencing (GO:0006342)3.07260430
129meiotic cell cycle (GO:0051321)3.06624129
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.01713313
131protein targeting to Golgi (GO:0000042)2.98900879
132peptidyl-glutamic acid carboxylation (GO:0017187)2.97320497
133protein carboxylation (GO:0018214)2.97320497
134carnitine transmembrane transport (GO:1902603)2.96484164
135DNA conformation change (GO:0071103)2.96371035
136polyol catabolic process (GO:0046174)2.92638222
137nucleoside diphosphate phosphorylation (GO:0006165)2.91817318
138regulation of cell aging (GO:0090342)2.90893654
139protein localization to cilium (GO:0061512)2.87580563
140mitochondrion degradation (GO:0000422)2.87522052
141retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87379572
142negative regulation of gene expression, epigenetic (GO:0045814)2.85984792
143alditol metabolic process (GO:0019400)2.84938113
144reciprocal meiotic recombination (GO:0007131)2.84774140
145reciprocal DNA recombination (GO:0035825)2.84774140
146regulation of cilium assembly (GO:1902017)2.84585521
147membrane protein intracellular domain proteolysis (GO:0031293)2.71532461
148monoubiquitinated protein deubiquitination (GO:0035520)2.60918406
149GTP biosynthetic process (GO:0006183)2.60300788
150meiotic cell cycle process (GO:1903046)2.58605789
151cilium organization (GO:0044782)2.56251699
152nucleosome disassembly (GO:0006337)2.53464819
153protein-DNA complex disassembly (GO:0032986)2.53464819
154positive regulation of glycolytic process (GO:0045821)2.53337566
155cilium morphogenesis (GO:0060271)2.53153833
156synapsis (GO:0007129)2.51064896
157cellular component assembly involved in morphogenesis (GO:0010927)2.50956645
158microtubule-based movement (GO:0007018)2.48843112
159cilium assembly (GO:0042384)2.46635226
160peptidyl-glutamic acid modification (GO:0018200)2.44326051
161axoneme assembly (GO:0035082)2.39775487
162protein depolymerization (GO:0051261)2.35885339
163sperm motility (GO:0030317)14.4363981
164cell wall macromolecule metabolic process (GO:0044036)13.8618539
165cell wall macromolecule catabolic process (GO:0016998)13.8618539
166acrosome reaction (GO:0007340)13.0208491
167fusion of sperm to egg plasma membrane (GO:0007342)12.6228304
168acrosome assembly (GO:0001675)11.6546909
169sperm-egg recognition (GO:0035036)11.6503863
170rRNA methylation (GO:0031167)10.6964652
171binding of sperm to zona pellucida (GO:0007339)10.6406871
172cell-cell recognition (GO:0009988)10.4298242
173multicellular organism reproduction (GO:0032504)10.2154127
174spermatid development (GO:0007286)10.0058871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.76922326
2EZH2_22144423_ChIP-Seq_EOC_Human4.19496349
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.56666494
4* VDR_21846776_ChIP-Seq_THP-1_Human3.48689102
5LXR_22292898_ChIP-Seq_THP-1_Human3.25375301
6* P68_20966046_ChIP-Seq_HELA_Human3.19747108
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05148823
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.98374199
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.93573922
10* CTCF_27219007_Chip-Seq_Bcells_Human2.72822862
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69803599
12VDR_22108803_ChIP-Seq_LS180_Human2.65990879
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51904353
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.41908695
15* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.32680389
16* E2F1_20622854_ChIP-Seq_HELA_Human2.32431118
17* SMC4_20622854_ChIP-Seq_HELA_Human2.31887868
18* MAF_26560356_Chip-Seq_TH2_Human2.29575206
19* PHF8_20622854_ChIP-Seq_HELA_Human2.27481809
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.26223881
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.25607190
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25301349
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22054304
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.14438388
25ZNF274_21170338_ChIP-Seq_K562_Hela2.09222686
26* SMAD2/3_21741376_ChIP-Seq_ESCs_Human2.03451345
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00778711
28ERA_21632823_ChIP-Seq_H3396_Human1.98783087
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97264301
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96260246
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87055293
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85666852
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84280633
34* VDR_24763502_ChIP-Seq_THP-1_Human1.81972854
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.81892835
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.80486575
37* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.78864293
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.77763500
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.77522644
40* SA1_27219007_Chip-Seq_ERYTHROID_Human1.76065187
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.75387938
42RACK7_27058665_Chip-Seq_MCF-7_Human1.74736051
43RARB_24833708_ChIP-Seq_LIVER_Mouse1.73031781
44STAT1_17558387_ChIP-Seq_HELA_Human1.72829250
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.72764402
46CTCF_21964334_Chip-Seq_Bcells_Human1.69727745
47FOXP1_21924763_ChIP-Seq_HESCs_Human1.69305296
48* MAF_26560356_Chip-Seq_TH1_Human1.68642645
49GATA3_21867929_ChIP-Seq_CD8_Mouse1.68239994
50* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.68000684
51TP63_22573176_ChIP-Seq_HFKS_Human1.67062330
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66699574
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61320572
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60903754
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60277581
56* XRN2_22483619_ChIP-Seq_HELA_Human1.59737242
57MYC_22102868_ChIP-Seq_BL_Human1.58358174
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.58063909
59P300_27268052_Chip-Seq_Bcells_Human1.57118599
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55302533
61GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53024541
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.52144107
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52056401
64KDM2B_26808549_Chip-Seq_DND41_Human1.51861396
65* SA1_27219007_Chip-Seq_Bcells_Human1.51298606
66TCF7_22412390_ChIP-Seq_EML_Mouse1.50311691
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.48248191
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44928586
69P53_21459846_ChIP-Seq_SAOS-2_Human1.44063981
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41207049
71LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.40706883
72RAC3_21632823_ChIP-Seq_H3396_Human1.40668155
73TAF2_19829295_ChIP-Seq_ESCs_Human1.39389658
74REST_21632747_ChIP-Seq_MESCs_Mouse1.38541760
75CTCF_21964334_ChIP-Seq_BJAB-B_Human1.37763700
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.37219111
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36575774
78CREB1_26743006_Chip-Seq_LNCaP_Human1.36325880
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35528176
80* KDM2B_26808549_Chip-Seq_REH_Human1.35396287
81ETS1_21867929_ChIP-Seq_TH2_Mouse1.34983907
82CBP_20019798_ChIP-Seq_JUKART_Human1.34926597
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34926597
84TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.34556654
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34217348
86* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.33042215
87TP53_22127205_ChIP-Seq_IMR90_Human1.32865043
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32401889
89OCT4_20526341_ChIP-Seq_ESCs_Human1.32043188
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30949271
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.30679972
92GF1_26923725_Chip-Seq_HPCs_Mouse1.28328400
93CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27409538
94SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27206751
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26658805
96* RUNX1_27514584_Chip-Seq_MCF-7_Human1.26320784
97GATA3_21867929_ChIP-Seq_TH1_Mouse1.26040442
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25679595
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24991242
100DROSHA_22980978_ChIP-Seq_HELA_Human1.24749376
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.24243594
102UTX_26944678_Chip-Seq_JUKART_Human1.23775572
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23600444
104KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23322494
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23094757
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23061430
107RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22283709
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.22022782
109SPI1_26923725_Chip-Seq_HPCs_Mouse1.21289653
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20967665
111NCOR1_26117541_ChIP-Seq_K562_Human1.20145908
112* OCT4_19829295_ChIP-Seq_ESCs_Human1.20108610
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.20001406
114PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18990869
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18440581
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18092672
117JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.17183643
118KDM2B_26808549_Chip-Seq_K562_Human1.16368880
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16195326
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15922295
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15367021
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15271584
123CBX2_27304074_Chip-Seq_ESCs_Mouse1.15027111
124MYC_19829295_ChIP-Seq_ESCs_Human1.13389959
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13355855
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11848135
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11848135
128* MYC_27129775_Chip-Seq_CORNEA_Mouse1.11839031
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11687052
130SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11664965
131TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11429088
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11280101
133TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11140006
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10484891
135RARA_24833708_ChIP-Seq_LIVER_Mouse1.10415786
136CTCF_20526341_ChIP-Seq_ESCs_Human1.10064833
137YY1_22570637_ChIP-Seq_MALME-3M_Human1.10049912
138* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09737805
139RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09370613
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09172461
141BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09110360
142ERG_20517297_ChIP-Seq_VCAP_Human1.08809078
143GATA1_19941826_ChIP-Seq_K562_Human1.08528626
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07921766
145ESET_19884257_ChIP-Seq_ESCs_Mouse1.07378694
146NFE2_27457419_Chip-Seq_LIVER_Mouse1.07110586
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06929664
148* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06406661
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05417046
150ATF3_27146783_Chip-Seq_COLON_Human1.03887260
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03787660
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02773628
153ELF1_20517297_ChIP-Seq_JURKAT_Human1.01629053
154SOX11_22085726_ChIP-Seq_ESNs_Mouse1.01271865
155SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00934156
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00166383
157LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99962445
158MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99777170
159P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99703859
160TAF15_26573619_Chip-Seq_HEK293_Human0.97371953
161CRX_20693478_ChIP-Seq_RETINA_Mouse0.97164214
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94758707
163* BCOR_27268052_Chip-Seq_Bcells_Human0.94649449
164RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94120357
165NANOG_18555785_Chip-Seq_ESCs_Mouse0.92944163
166SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92783990
167PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92452581
168SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91643456
169ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90801684
170BCL6_27268052_Chip-Seq_Bcells_Human0.90445436
171NANOG_20526341_ChIP-Seq_ESCs_Human0.90271868
172KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89847684
173* FLI1_21867929_ChIP-Seq_CD8_Mouse0.88152987
174SOX2_21211035_ChIP-Seq_LN229_Human0.86474557
175SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85724246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.72926189
2MP0001986_abnormal_taste_sensitivity6.55801237
3MP0005423_abnormal_somatic_nervous6.38041709
4MP0005171_absent_coat_pigmentation6.29924654
5MP0003698_abnormal_male_reproductive6.01342151
6MP0005174_abnormal_tail_pigmentation5.91459658
7MP0001929_abnormal_gametogenesis5.50028661
8MP0005409_darkened_coat_color4.20351819
9MP0001188_hyperpigmentation4.06795788
10MP0008877_abnormal_DNA_methylation3.54514019
11MP0005670_abnormal_white_adipose3.31026056
12MP0002161_abnormal_fertility/fecundity3.28512959
13MP0002210_abnormal_sex_determination3.17634334
14MP0001145_abnormal_male_reproductive2.70377773
15MP0005083_abnormal_biliary_tract2.58836194
16MP0000015_abnormal_ear_pigmentation2.43999950
17MP0004381_abnormal_hair_follicle2.42164610
18MP0000653_abnormal_sex_gland2.32948212
19MP0002638_abnormal_pupillary_reflex2.02653731
20MP0005410_abnormal_fertilization16.9325890
21MP0001756_abnormal_urination1.86732056
22MP0002653_abnormal_ependyma_morphology1.83830063
23MP0004233_abnormal_muscle_weight1.66082687
24MP0010386_abnormal_urinary_bladder1.63610583
25MP0003646_muscle_fatigue1.59827885
26MP0001348_abnormal_lacrimal_gland1.59314898
27MP0002735_abnormal_chemical_nociception1.55957716
28MP0000538_abnormal_urinary_bladder1.47442939
29MP0001502_abnormal_circadian_rhythm1.45766932
30MP0003693_abnormal_embryo_hatching1.45485545
31MP0000003_abnormal_adipose_tissue1.39993801
32MP0002160_abnormal_reproductive_system1.37060865
33MP0000013_abnormal_adipose_tissue1.30366604
34MP0005076_abnormal_cell_differentiation1.26983798
35MP0002234_abnormal_pharynx_morphology1.21773114
36MP0003705_abnormal_hypodermis_morpholog1.17975643
37MP0004957_abnormal_blastocyst_morpholog1.12770562
38MP0001984_abnormal_olfaction1.09918717
39MP0005623_abnormal_meninges_morphology1.09739947
40MP0001765_abnormal_ion_homeostasis1.07219553
41MP0000678_abnormal_parathyroid_gland1.06183795
42MP0005332_abnormal_amino_acid1.03833406
43MP0003453_abnormal_keratinocyte_physiol0.98220256
44MP0004130_abnormal_muscle_cell0.96350863
45MP0002282_abnormal_trachea_morphology0.95794322
46MP0003077_abnormal_cell_cycle0.95200405
47MP0005584_abnormal_enzyme/coenzyme_acti0.93961212
48MP0005084_abnormal_gallbladder_morpholo0.92909605
49MP0003091_abnormal_cell_migration0.84794106
50MP0001873_stomach_inflammation0.76078794
51MP0003115_abnormal_respiratory_system0.75109418
52MP0000750_abnormal_muscle_regeneration0.73812640
53MP0005647_abnormal_sex_gland0.71048668
54MP0003011_delayed_dark_adaptation0.70032408
55MP0002249_abnormal_larynx_morphology0.69803738
56MP0003329_amyloid_beta_deposits0.68454443
57MP0009053_abnormal_anal_canal0.68390833
58MP0001664_abnormal_digestion0.66849392
59MP0009046_muscle_twitch0.66271789
60MP0005666_abnormal_adipose_tissue0.65235795
61MP0005389_reproductive_system_phenotype0.63783289
62MP0003632_abnormal_nervous_system0.63533738
63MP0002075_abnormal_coat/hair_pigmentati0.63470385
64MP0002736_abnormal_nociception_after0.63334716
65MP0008995_early_reproductive_senescence0.61142195
66MP0005636_abnormal_mineral_homeostasis0.60910072
67MP0008058_abnormal_DNA_repair0.60330823
68MP0003718_maternal_effect0.58645021
69MP0001970_abnormal_pain_threshold0.56592236
70MP0004036_abnormal_muscle_relaxation0.54495786
71MP0002019_abnormal_tumor_incidence0.54067728
72MP0002269_muscular_atrophy0.53792111
73MP0000367_abnormal_coat/_hair0.53600551
74MP0001958_emphysema0.51569239
75MP0005377_hearing/vestibular/ear_phenot0.51397876
76MP0003878_abnormal_ear_physiology0.51397876
77MP0001764_abnormal_homeostasis0.51183069
78MP0000371_diluted_coat_color0.49482214
79MP0001324_abnormal_eye_pigmentation0.47511197
80MP0000534_abnormal_ureter_morphology0.47429350
81MP0005220_abnormal_exocrine_pancreas0.47064575
82MP0001905_abnormal_dopamine_level0.46954016
83MP0003448_altered_tumor_morphology0.45932927
84MP0000470_abnormal_stomach_morphology0.45786889
85MP0003137_abnormal_impulse_conducting0.44388205
86MP0006036_abnormal_mitochondrial_physio0.44130723
87MP0002136_abnormal_kidney_physiology0.43671141
88MP0002933_joint_inflammation0.42575076
89MP0003699_abnormal_female_reproductive0.42299217
90MP0000026_abnormal_inner_ear0.41714073
91MP0005451_abnormal_body_composition0.41057371
92MP0005085_abnormal_gallbladder_physiolo0.40597330
93MP0000358_abnormal_cell_content/0.39925787
94MP0001293_anophthalmia0.39601263
95MP0001968_abnormal_touch/_nociception0.38015160
96MP0009115_abnormal_fat_cell0.37924413
97MP0005397_hematopoietic_system_phenotyp0.36737857
98MP0001545_abnormal_hematopoietic_system0.36737857
99MP0009278_abnormal_bone_marrow0.36256594
100MP0000604_amyloidosis0.36228490
101MP0008057_abnormal_DNA_replication0.35788186
102MP0000747_muscle_weakness0.35442653
103MP0005253_abnormal_eye_physiology0.35347977
104MP0009931_abnormal_skin_appearance0.35059331
105MP0002928_abnormal_bile_duct0.35005265
106MP0002139_abnormal_hepatobiliary_system0.34484274
107MP0005551_abnormal_eye_electrophysiolog0.34191556
108MP0002132_abnormal_respiratory_system0.34118518
109MP0004133_heterotaxia0.33613019
110MP0009643_abnormal_urine_homeostasis0.33346578
111MP0001963_abnormal_hearing_physiology0.33183547
112MP0003942_abnormal_urinary_system0.33013002
113MP0010771_integument_phenotype0.32376684
114MP0004811_abnormal_neuron_physiology0.32130940
115MP0001186_pigmentation_phenotype0.30794554
116MP0004197_abnormal_fetal_growth/weight/0.30519490
117MP0003943_abnormal_hepatobiliary_system0.30474384
118MP0008770_decreased_survivor_rate0.30472943
119MP0000569_abnormal_digit_pigmentation0.29991929
120MP0003633_abnormal_nervous_system0.29977716
121MP0002095_abnormal_skin_pigmentation0.29113590
122MP0008007_abnormal_cellular_replicative0.28872954
123MP0003950_abnormal_plasma_membrane0.28373472
124MP0002971_abnormal_brown_adipose0.27732488
125MP0005391_vision/eye_phenotype0.26094646
126MP0002169_no_abnormal_phenotype0.25310913
127MP0003879_abnormal_hair_cell0.25112631
128MP0002873_normal_phenotype0.25090993
129MP0003948_abnormal_gas_homeostasis0.25077274
130MP0003631_nervous_system_phenotype0.24711514
131MP0001730_embryonic_growth_arrest0.24187129
132MP0003861_abnormal_nervous_system0.23965545
133MP0004742_abnormal_vestibular_system0.23471320
134MP0002152_abnormal_brain_morphology0.22801747
135MP0005375_adipose_tissue_phenotype0.22206105
136MP0002102_abnormal_ear_morphology0.22107740
137MP0001849_ear_inflammation0.21472546
138MP0002295_abnormal_pulmonary_circulatio0.21247497
139MP0002909_abnormal_adrenal_gland0.20527281
140MP0010094_abnormal_chromosome_stability0.20496482
141MP0004270_analgesia0.20185318
142MP0004019_abnormal_vitamin_homeostasis0.19685584
143MP0008875_abnormal_xenobiotic_pharmacok0.19433315
144MP0004145_abnormal_muscle_electrophysio0.19138729
145MP0008961_abnormal_basal_metabolism0.18900200
146MP0006035_abnormal_mitochondrial_morpho0.18879123
147MP0003787_abnormal_imprinting0.18697845
148MP0003111_abnormal_nucleus_morphology0.18405578
149MP0008569_lethality_at_weaning0.18322110
150MP0004043_abnormal_pH_regulation0.18154192
151MP0005365_abnormal_bile_salt0.17531608
152MP0000751_myopathy0.17107731
153MP0001119_abnormal_female_reproductive0.16439607
154MP0000462_abnormal_digestive_system0.16385557
155MP0003959_abnormal_lean_body0.15443522
156MP0002118_abnormal_lipid_homeostasis0.15205522
157MP0000001_mammalian_phenotype0.14896580
158MP0005503_abnormal_tendon_morphology0.14643621
159MP0002693_abnormal_pancreas_physiology0.14366272
160MP0002229_neurodegeneration0.13748443
161MP0002822_catalepsy0.13734267
162MP0001270_distended_abdomen0.13004953
163MP0002092_abnormal_eye_morphology0.12866913
164MP0005319_abnormal_enzyme/_coenzyme0.12702731
165MP0005535_abnormal_body_temperature0.12488927
166MP0000920_abnormal_myelination0.12429007
167MP0001661_extended_life_span0.12364699

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.28104105
2Abnormal respiratory motile cilium morphology (HP:0005938)9.28104105
3Abnormal respiratory motile cilium physiology (HP:0012261)9.26629848
4Chronic bronchitis (HP:0004469)7.42577035
5Rhinitis (HP:0012384)7.35681646
6Infertility (HP:0000789)7.31219713
7Abnormal ciliary motility (HP:0012262)7.07256150
8Nasal polyposis (HP:0100582)6.47133052
9Rib fusion (HP:0000902)5.88658702
10Intestinal fistula (HP:0100819)5.83216596
11Rectovaginal fistula (HP:0000143)5.77242673
12Rectal fistula (HP:0100590)5.77242673
13Attenuation of retinal blood vessels (HP:0007843)5.49038243
14Abnormality of the nasal mucosa (HP:0000433)5.32448610
15Vaginal fistula (HP:0004320)5.26348706
16Male infertility (HP:0003251)5.05044628
17Poikiloderma (HP:0001029)4.98267743
18Bony spicule pigmentary retinopathy (HP:0007737)4.98091230
19Ulnar bowing (HP:0003031)4.97620427
20Congenital stationary night blindness (HP:0007642)4.77347794
21Annular pancreas (HP:0001734)4.66536705
22Bronchitis (HP:0012387)4.55982517
23Turricephaly (HP:0000262)4.52527339
24Thin bony cortex (HP:0002753)4.49089718
25Facial hemangioma (HP:0000329)4.46157358
26Bronchiectasis (HP:0002110)4.34364152
27Testicular atrophy (HP:0000029)4.19819151
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.07963733
29Chorioretinal atrophy (HP:0000533)4.07412014
30Popliteal pterygium (HP:0009756)4.02444710
31Coronal craniosynostosis (HP:0004440)3.94513152
32Nephronophthisis (HP:0000090)3.84397804
33Abnormal spermatogenesis (HP:0008669)3.79878160
34Short chin (HP:0000331)3.77985875
35Enlarged epiphyses (HP:0010580)3.52973945
36Aplasia of the musculature (HP:0100854)3.45138026
37Patellar aplasia (HP:0006443)3.44632135
38Fetal akinesia sequence (HP:0001989)3.41154158
39Birth length less than 3rd percentile (HP:0003561)3.40411914
40Squamous cell carcinoma (HP:0002860)3.39431928
41Anteriorly placed anus (HP:0001545)3.35923137
42Abnormality of the costochondral junction (HP:0000919)3.33974859
43Recurrent otitis media (HP:0000403)3.26686079
44Abnormality of the intrinsic pathway (HP:0010989)3.19736881
45Delayed epiphyseal ossification (HP:0002663)3.14696545
46Aplasia/Hypoplasia of the patella (HP:0006498)3.14528207
47Akinesia (HP:0002304)3.10881005
48Recurrent sinusitis (HP:0011108)3.06835776
49Absent thumb (HP:0009777)2.93809660
50Pendular nystagmus (HP:0012043)2.87063675
51Abnormality of the renal medulla (HP:0100957)2.85340447
52Severe visual impairment (HP:0001141)2.84950933
53Chronic hepatic failure (HP:0100626)2.82667868
54Widely patent fontanelles and sutures (HP:0004492)2.81842258
55Impulsivity (HP:0100710)2.80015232
56Cholecystitis (HP:0001082)2.75433139
57Abnormal gallbladder physiology (HP:0012438)2.75433139
58Abnormality of the hepatic vasculature (HP:0006707)2.74936721
59Hypophosphatemic rickets (HP:0004912)2.73446891
60Hypoalbuminemia (HP:0003073)2.70953993
61Abnormal albumin level (HP:0012116)2.70953993
62Amniotic constriction ring (HP:0009775)2.65268493
63Abnormality of placental membranes (HP:0011409)2.65268493
64Increased number of teeth (HP:0011069)2.65083601
65Recurrent bronchitis (HP:0002837)2.64919506
66Capillary hemangiomas (HP:0005306)2.62497819
67Abnormality of homocysteine metabolism (HP:0010919)2.62152140
68Homocystinuria (HP:0002156)2.62152140
69Absent radius (HP:0003974)2.61810786
70Tubulointerstitial nephritis (HP:0001970)2.54042689
71Bowed forearm bones (HP:0003956)2.51080394
72Bowing of the arm (HP:0006488)2.51080394
73Facial diplegia (HP:0001349)2.49185324
74Tubular atrophy (HP:0000092)2.47599305
75Breast hypoplasia (HP:0003187)2.43871481
76Aplasia involving forearm bones (HP:0009822)2.43766682
77Absent forearm bone (HP:0003953)2.43766682
78Choanal stenosis (HP:0000452)2.43294920
79Short humerus (HP:0005792)2.42531542
80Flat occiput (HP:0005469)2.37105603
81Abnormality of midbrain morphology (HP:0002418)2.36669772
82Molar tooth sign on MRI (HP:0002419)2.36669772
83Premature graying of hair (HP:0002216)2.36664051
84Medial flaring of the eyebrow (HP:0010747)2.34349031
85Dyschromatopsia (HP:0007641)2.33893774
86Azoospermia (HP:0000027)2.33868422
87Tubulointerstitial abnormality (HP:0001969)2.30081406
88Polyuria (HP:0000103)2.29822347
89Narrow nasal bridge (HP:0000446)2.28084940
90Joint stiffness (HP:0001387)2.27506753
91Decreased circulating renin level (HP:0003351)2.26199328
92Choroideremia (HP:0001139)2.23752165
93Short thumb (HP:0009778)2.19505195
94Aplasia/hypoplasia of the humerus (HP:0006507)2.19049618
95Aplasia/Hypoplasia involving the musculature (HP:0001460)2.16944875
96Gonadotropin excess (HP:0000837)2.16881917
97Reduced antithrombin III activity (HP:0001976)2.15032361
98Congenital malformation of the right heart (HP:0011723)2.13138263
99Double outlet right ventricle (HP:0001719)2.13138263
100Prolonged partial thromboplastin time (HP:0003645)2.11360460
101Hypoplasia of the pons (HP:0012110)2.09609965
102Basal cell carcinoma (HP:0002671)2.07475467
103Malignant hyperthermia (HP:0002047)2.07242533
104Decreased central vision (HP:0007663)2.06402294
105Spastic tetraparesis (HP:0001285)2.05559120
106Thin ribs (HP:0000883)2.00745779
107Dynein arm defect of respiratory motile cilia (HP:0012255)13.4162318
108Absent/shortened dynein arms (HP:0200106)13.4162318
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8451146
110Tubulointerstitial fibrosis (HP:0005576)1.96937440
111Neurofibrillary tangles (HP:0002185)1.92260001
112Hemorrhage of the eye (HP:0011885)1.91095851
113Hyperkalemia (HP:0002153)1.87712258
114Abnormality of the pons (HP:0007361)1.85297440
115Generalized aminoaciduria (HP:0002909)1.79386022
116Bifid uvula (HP:0000193)1.77350165
117Atrioventricular block (HP:0001678)1.75580067
118Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75014039
119Abnormality of the nasal septum (HP:0000419)1.74582737
120Joint hemorrhage (HP:0005261)1.74534974
121Muscle fiber atrophy (HP:0100295)1.74276782
122Small hand (HP:0200055)1.74204199
123Hypoalphalipoproteinemia (HP:0003233)1.73999876
124Abnormality of the fingertips (HP:0001211)1.71687913
125Polydipsia (HP:0001959)1.71357628
126Abnormal drinking behavior (HP:0030082)1.71357628
127Heterotopia (HP:0002282)1.68563101
128Aplasia/Hypoplasia of the lens (HP:0008063)1.64495335
129Exercise-induced myalgia (HP:0003738)1.64306162
130Stage 5 chronic kidney disease (HP:0003774)1.62942293
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60841233
132Easy fatigability (HP:0003388)1.59862431
133Abnormality of renal excretion (HP:0011036)1.58894632
134Cerebral inclusion bodies (HP:0100314)1.58031772
135Abnormal biliary tract physiology (HP:0012439)1.56676645
136Bile duct proliferation (HP:0001408)1.56676645
137Postaxial foot polydactyly (HP:0001830)1.55841252
138Congenital hepatic fibrosis (HP:0002612)1.52139920
139Fatigable weakness (HP:0003473)1.49663097
140Abnormality of the neuromuscular junction (HP:0003398)1.49663097
141Bundle branch block (HP:0011710)1.49374692
142Sensory axonal neuropathy (HP:0003390)1.48842281
143Myoglobinuria (HP:0002913)1.48821947
144Asymmetric septal hypertrophy (HP:0001670)1.47161487
145Bell-shaped thorax (HP:0001591)1.46808587
146Abnormality of the renal cortex (HP:0011035)1.43220201
147Loss of speech (HP:0002371)1.42009518
148Hypercholesterolemia (HP:0003124)1.41991079
149Short ribs (HP:0000773)1.41780752
150Abnormality of dentin (HP:0010299)1.41601235
151Abnormal urine output (HP:0012590)1.37670221
152Renal dysplasia (HP:0000110)1.35327440
153Oculomotor apraxia (HP:0000657)1.34811336
154Cerebellar dysplasia (HP:0007033)1.33602065
155Rhabdomyolysis (HP:0003201)1.33458455
156Neoplasm of the heart (HP:0100544)1.31731546
157Constricted visual fields (HP:0001133)1.31623255
158Postaxial hand polydactyly (HP:0001162)1.31536679
159Exercise-induced muscle cramps (HP:0003710)1.29268846
160Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.27682081
161Absent epiphyses (HP:0010577)1.27682081
162Hemiparesis (HP:0001269)1.27322843
163Abnormality of the dental pulp (HP:0006479)1.27164424
164Abnormality of the dental root (HP:0006486)1.26721222
165Taurodontia (HP:0000679)1.26721222
166Abnormality of permanent molar morphology (HP:0011071)1.26721222
167Generalized muscle weakness (HP:0003324)1.25809450
168Gait imbalance (HP:0002141)1.25141882
169Type 2 muscle fiber atrophy (HP:0003554)1.24690132
170Congenital primary aphakia (HP:0007707)1.24650735
171Chronic sinusitis (HP:0011109)1.24134753
172Deformed sella turcica (HP:0002681)1.23265050
173Facial cleft (HP:0002006)1.23071134
174Decreased muscle mass (HP:0003199)1.23037495
175Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.22021044
176Bulbar palsy (HP:0001283)1.21645543
177Retinal dysplasia (HP:0007973)1.20816212
178Short femoral neck (HP:0100864)1.20649222
179Cystic liver disease (HP:0006706)1.18858160
180Truncal obesity (HP:0001956)1.17303544
181Fibular hypoplasia (HP:0003038)1.16556162
182Abnormality of molar (HP:0011077)1.15844055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.48313440
2PDK37.48313440
3TESK17.28578341
4PRKD35.50698410
5ICK5.11434462
6PDK24.82261881
7BLK3.27510590
8ACVR1B2.99905707
9GRK62.47723865
10PTK2B2.21980853
11TLK12.21978047
12WNK42.21477093
13STK392.15244493
14BRD42.11490035
15STK382.09830882
16SIK22.02802439
17BMPR1B1.97704909
18ZAK1.92168510
19MST1R1.87748371
20DYRK1B1.82733626
21DDR21.59313489
22NEK21.57545280
23INSRR1.56137580
24MAPK111.49919277
25PNCK1.47197658
26PDK11.36500232
27STK161.26025324
28PIM21.18511912
29AKT31.12295369
30CAMK1D1.09543711
31RPS6KA21.00510603
32MELK0.98316750
33PDPK10.97836091
34DYRK30.95956588
35ADRBK10.93276901
36RIPK40.93095657
37ERN10.92922911
38MAPK150.89046654
39IRAK10.87213219
40MAP2K30.85836398
41TYRO30.85125161
42ZAP700.84213945
43RPS6KA60.83344225
44WNK10.81870410
45EEF2K0.78983742
46SGK2230.75567354
47SGK4940.75567354
48RPS6KC10.72816075
49RPS6KL10.72816075
50SIK10.72742251
51TESK20.70802803
52TGFBR10.69236843
53CCNB10.67785189
54FRK0.67718690
55PASK0.65409256
56RAF10.62294246
57ADRBK20.61934439
58PINK10.60911296
59CHEK20.59625650
60MAP3K70.58642020
61STK30.58637617
62CDK70.56989319
63TTK0.56133480
64KSR20.55767531
65NTRK20.54948101
66MUSK0.53656313
67MAPK120.52404905
68IRAK20.48462994
69MAP2K60.47898017
70PIK3CG0.47150588
71PRKD20.46943140
72MAP3K100.46585189
73CAMK10.45467912
74PRKAA20.43326105
75PKN20.43183942
76PRKCG0.43144212
77CAMK1G0.41445193
78STK38L0.40990269
79PAK10.40722814
80LMTK20.40644546
81TRPM70.40212976
82MAPKAPK50.39747285
83MAP4K20.38069040
84RPS6KA50.37408191
85MAPK10.36514279
86MET0.36457396
87DAPK20.32922361
88MAP2K20.32317254
89PAK40.31261787
90CHEK10.30967040
91MARK20.30879550
92PAK20.30472267
93SMG10.28688532
94PLK20.28136939
95MAPK100.26616844
96SGK10.26525406
97CAMKK10.26169175
98PRKD10.25940959
99PRKCZ0.24270844
100MTOR0.22650582
101CDK150.21349988
102ATM0.20765808
103PRKCQ0.20209391
104CDK180.18361924
105PRKAA10.17956318
106CDK11A0.16954353
107BRSK20.15698531
108PRKG20.15286880
109ATR0.14871071
110NEK60.13424278
111CSF1R0.12269060
112CDK140.12119059
113RPS6KB10.11363320
114BRSK10.11281856
115BRAF0.10762068
116RPS6KA10.10551639
117STK100.09021391
118PLK40.07978768
119GSK3B0.06508525
120PKN10.06314442
121PRKCD0.06256406
122CLK10.06150840
123PLK10.06114169
124CAMK2A0.06053882
125CSNK2A10.05923629
126STK110.05898034
127CDK60.04629765
128PRKG10.03375235
129PRKACG0.03221644
130MARK30.02851592
131EPHB10.02819608
132PIM10.02714275
133PRKCA0.02526125
134PRKCB0.02129604
135MAPK80.01907987
136PDGFRB0.00628331
137SRC-0.0547167
138CDK12-0.0476970
139PRKACB-0.0449387
140CDK4-0.0353018
141PRKACA-0.0345337
142RPS6KA3-0.0279944
143PAK6-0.0236367
144YES1-0.0210505
145CSNK2A2-0.0153628
146TRIB3-0.0124517
147CSNK1D-0.0103887
148MAP3K1-0.0089830
149CDK1-0.0045453
150EGFR-0.0031865
151CDK2-0.0030815
152AURKA-0.0018679
153WEE1-0.0002697

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.64543255
2Sulfur relay system_Homo sapiens_hsa041226.17305504
3Fatty acid biosynthesis_Homo sapiens_hsa000615.09557211
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.35643764
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.78556253
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.46776369
7Linoleic acid metabolism_Homo sapiens_hsa005913.36149183
8Vitamin B6 metabolism_Homo sapiens_hsa007503.06107554
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.05387688
10Pyruvate metabolism_Homo sapiens_hsa006203.04098825
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.02738105
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.92487187
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.51112385
14Glucagon signaling pathway_Homo sapiens_hsa049222.45562778
15Propanoate metabolism_Homo sapiens_hsa006402.35713731
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29327745
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.01126210
18Basal transcription factors_Homo sapiens_hsa030222.01048874
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.95602867
20PPAR signaling pathway_Homo sapiens_hsa033201.95365966
21Glycerolipid metabolism_Homo sapiens_hsa005611.93431012
22Selenocompound metabolism_Homo sapiens_hsa004501.86394542
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.84343531
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.77682496
25Fat digestion and absorption_Homo sapiens_hsa049751.74159716
26Circadian rhythm_Homo sapiens_hsa047101.71840418
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.70167571
28Fructose and mannose metabolism_Homo sapiens_hsa000511.64445754
29Ether lipid metabolism_Homo sapiens_hsa005651.62894402
30Mineral absorption_Homo sapiens_hsa049781.60753650
31Fatty acid degradation_Homo sapiens_hsa000711.59310181
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59086857
33Fatty acid metabolism_Homo sapiens_hsa012121.58136407
34Lysine degradation_Homo sapiens_hsa003101.56080416
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55604554
36Amphetamine addiction_Homo sapiens_hsa050311.53436289
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40385337
38Oocyte meiosis_Homo sapiens_hsa041141.39812208
39Cardiac muscle contraction_Homo sapiens_hsa042601.34241056
40Pentose phosphate pathway_Homo sapiens_hsa000301.32215749
41Vitamin digestion and absorption_Homo sapiens_hsa049771.31101624
42Carbon metabolism_Homo sapiens_hsa012001.30645805
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29437434
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21853562
45Phenylalanine metabolism_Homo sapiens_hsa003601.21520370
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.18145495
47Dorso-ventral axis formation_Homo sapiens_hsa043201.17816670
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17349936
49Nicotine addiction_Homo sapiens_hsa050331.15034882
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10707643
51Sphingolipid metabolism_Homo sapiens_hsa006001.10271300
52Hedgehog signaling pathway_Homo sapiens_hsa043401.07906248
53Glutathione metabolism_Homo sapiens_hsa004801.07698695
54Homologous recombination_Homo sapiens_hsa034401.05948713
55Collecting duct acid secretion_Homo sapiens_hsa049661.04783364
56Renin secretion_Homo sapiens_hsa049241.03132424
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03075809
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.99042151
59Arginine biosynthesis_Homo sapiens_hsa002200.96369477
60Arachidonic acid metabolism_Homo sapiens_hsa005900.95542484
61Antigen processing and presentation_Homo sapiens_hsa046120.94731766
62Insulin secretion_Homo sapiens_hsa049110.93041525
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.92609532
64Purine metabolism_Homo sapiens_hsa002300.90197758
65Chemical carcinogenesis_Homo sapiens_hsa052040.88287577
66Bile secretion_Homo sapiens_hsa049760.82292882
67Fanconi anemia pathway_Homo sapiens_hsa034600.82129152
68RNA polymerase_Homo sapiens_hsa030200.78925184
69Thyroid hormone synthesis_Homo sapiens_hsa049180.78570206
70Hippo signaling pathway_Homo sapiens_hsa043900.77799429
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77148097
72Estrogen signaling pathway_Homo sapiens_hsa049150.76917295
73Biosynthesis of amino acids_Homo sapiens_hsa012300.76002401
74Long-term potentiation_Homo sapiens_hsa047200.75270288
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74528239
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74007121
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73711343
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72636310
79Huntingtons disease_Homo sapiens_hsa050160.68509538
80mRNA surveillance pathway_Homo sapiens_hsa030150.68127180
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66807617
82Pancreatic secretion_Homo sapiens_hsa049720.64688145
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.63771255
84Systemic lupus erythematosus_Homo sapiens_hsa053220.62889185
85Cell cycle_Homo sapiens_hsa041100.62075686
86Salivary secretion_Homo sapiens_hsa049700.61417934
87Olfactory transduction_Homo sapiens_hsa047400.57054696
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.56696891
89Synaptic vesicle cycle_Homo sapiens_hsa047210.56542513
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.56231212
91Renin-angiotensin system_Homo sapiens_hsa046140.54158392
92Legionellosis_Homo sapiens_hsa051340.54139548
93Tyrosine metabolism_Homo sapiens_hsa003500.52988274
94Bladder cancer_Homo sapiens_hsa052190.52500639
95mTOR signaling pathway_Homo sapiens_hsa041500.52081114
96Protein digestion and absorption_Homo sapiens_hsa049740.51637711
97Melanogenesis_Homo sapiens_hsa049160.50508780
98ABC transporters_Homo sapiens_hsa020100.50188051
99One carbon pool by folate_Homo sapiens_hsa006700.49262300
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48701148
101Gastric acid secretion_Homo sapiens_hsa049710.48302669
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46673105
103Calcium signaling pathway_Homo sapiens_hsa040200.46289169
104Retinol metabolism_Homo sapiens_hsa008300.44530300
105Sulfur metabolism_Homo sapiens_hsa009200.43923167
106Base excision repair_Homo sapiens_hsa034100.43873159
107AMPK signaling pathway_Homo sapiens_hsa041520.43765675
108Endocytosis_Homo sapiens_hsa041440.43114274
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42851854
110RNA transport_Homo sapiens_hsa030130.42836260
111MAPK signaling pathway_Homo sapiens_hsa040100.41458430
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41049016
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40083119
114Insulin resistance_Homo sapiens_hsa049310.39427091
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37678916
116VEGF signaling pathway_Homo sapiens_hsa043700.36873868
117TGF-beta signaling pathway_Homo sapiens_hsa043500.36856737
118Alcoholism_Homo sapiens_hsa050340.36513230
119Metabolic pathways_Homo sapiens_hsa011000.35823678
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32896185
121cAMP signaling pathway_Homo sapiens_hsa040240.32721822
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32436350
123Inositol phosphate metabolism_Homo sapiens_hsa005620.31708460
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30557163
125Cholinergic synapse_Homo sapiens_hsa047250.30443075
126Notch signaling pathway_Homo sapiens_hsa043300.30434630
127Cocaine addiction_Homo sapiens_hsa050300.29565251
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28472673
129Histidine metabolism_Homo sapiens_hsa003400.28117103
130Morphine addiction_Homo sapiens_hsa050320.27712323
131Circadian entrainment_Homo sapiens_hsa047130.25775857
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.25049774
133Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24396219
134Taste transduction_Homo sapiens_hsa047420.23513086
135Nitrogen metabolism_Homo sapiens_hsa009100.23268869
136Pyrimidine metabolism_Homo sapiens_hsa002400.23111154
137Ovarian steroidogenesis_Homo sapiens_hsa049130.21205698
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20358784
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.19810415
140FoxO signaling pathway_Homo sapiens_hsa040680.18956112
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18942063
142Gap junction_Homo sapiens_hsa045400.16637710
143Other glycan degradation_Homo sapiens_hsa005110.15348445
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.14499843
145Phototransduction_Homo sapiens_hsa047440.14236481
146Acute myeloid leukemia_Homo sapiens_hsa052210.13924892
147B cell receptor signaling pathway_Homo sapiens_hsa046620.12429828
148HIF-1 signaling pathway_Homo sapiens_hsa040660.11747597
149Basal cell carcinoma_Homo sapiens_hsa052170.11282424
150Salmonella infection_Homo sapiens_hsa051320.09762694
151Wnt signaling pathway_Homo sapiens_hsa043100.09749436
152Glutamatergic synapse_Homo sapiens_hsa047240.08442569
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08431524
154Type II diabetes mellitus_Homo sapiens_hsa049300.08253199
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.06267521

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