

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | plasma membrane fusion (GO:0045026) | 9.61292443 |
| 2 | motile cilium assembly (GO:0044458) | 9.47402021 |
| 3 | epithelial cilium movement (GO:0003351) | 9.34986234 |
| 4 | axonemal dynein complex assembly (GO:0070286) | 9.20366176 |
| 5 | reproduction (GO:0000003) | 9.05587273 |
| 6 | rRNA modification (GO:0000154) | 8.96432268 |
| 7 | cellular response to ATP (GO:0071318) | 8.78179731 |
| 8 | regulation of cilium movement (GO:0003352) | 8.60732961 |
| 9 | negative regulation of inclusion body assembly (GO:0090084) | 8.03831618 |
| 10 | meiotic chromosome segregation (GO:0045132) | 7.63144833 |
| 11 | cilium movement (GO:0003341) | 7.43145650 |
| 12 | DNA strand renaturation (GO:0000733) | 7.32393469 |
| 13 | cilium or flagellum-dependent cell motility (GO:0001539) | 7.27891055 |
| 14 | organic cation transport (GO:0015695) | 7.22699051 |
| 15 | sperm capacitation (GO:0048240) | 7.16288619 |
| 16 | spermatogenesis (GO:0007283) | 7.09986301 |
| 17 | male gamete generation (GO:0048232) | 7.07351249 |
| 18 | single fertilization (GO:0007338) | 7.04529131 |
| 19 | synaptonemal complex organization (GO:0070193) | 6.87047838 |
| 20 | microtubule depolymerization (GO:0007019) | 6.85296604 |
| 21 | adenosine receptor signaling pathway (GO:0001973) | 6.85117243 |
| 22 | GDP-mannose metabolic process (GO:0019673) | 6.84126969 |
| 23 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 6.79477157 |
| 24 | synaptonemal complex assembly (GO:0007130) | 6.79345001 |
| 25 | regulation of inclusion body assembly (GO:0090083) | 6.61047279 |
| 26 | gamete generation (GO:0007276) | 6.49705901 |
| 27 | chromosome condensation (GO:0030261) | 6.40821849 |
| 28 | male meiosis (GO:0007140) | 6.38368220 |
| 29 | positive regulation of protein kinase C signaling (GO:0090037) | 6.24558343 |
| 30 | negative regulation of cell aging (GO:0090344) | 6.19354462 |
| 31 | piRNA metabolic process (GO:0034587) | 6.17671787 |
| 32 | purinergic nucleotide receptor signaling pathway (GO:0035590) | 6.10552850 |
| 33 | DNA packaging (GO:0006323) | 6.05380250 |
| 34 | fertilization (GO:0009566) | 6.04990016 |
| 35 | urinary tract smooth muscle contraction (GO:0014848) | 5.99703014 |
| 36 | calcium ion-dependent exocytosis (GO:0017156) | 5.95923984 |
| 37 | adenine nucleotide transport (GO:0051503) | 5.91557590 |
| 38 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 5.90431354 |
| 39 | purine ribonucleotide transport (GO:0015868) | 5.88925534 |
| 40 | spermatid nucleus differentiation (GO:0007289) | 5.52067596 |
| 41 | germ cell development (GO:0007281) | 5.50400530 |
| 42 | glycerol ether metabolic process (GO:0006662) | 5.40837563 |
| 43 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 5.38813200 |
| 44 | sensory perception of taste (GO:0050909) | 5.36657191 |
| 45 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 5.18549347 |
| 46 | peristalsis (GO:0030432) | 5.18410190 |
| 47 | multicellular organismal reproductive process (GO:0048609) | 5.10437541 |
| 48 | regulation of microtubule-based movement (GO:0060632) | 5.09041318 |
| 49 | cell recognition (GO:0008037) | 5.08571844 |
| 50 | lens fiber cell differentiation (GO:0070306) | 5.03580108 |
| 51 | sexual reproduction (GO:0019953) | 4.99748269 |
| 52 | ether metabolic process (GO:0018904) | 4.99737486 |
| 53 | nucleotide transmembrane transport (GO:1901679) | 4.94681739 |
| 54 | regulation of protein kinase A signaling (GO:0010738) | 4.91551970 |
| 55 | nucleoside transmembrane transport (GO:1901642) | 4.91085131 |
| 56 | response to ATP (GO:0033198) | 4.87694319 |
| 57 | microtubule severing (GO:0051013) | 4.83980348 |
| 58 | ventricular system development (GO:0021591) | 4.83442546 |
| 59 | sex determination (GO:0007530) | 4.80672317 |
| 60 | purine nucleotide transport (GO:0015865) | 4.71482167 |
| 61 | seminiferous tubule development (GO:0072520) | 4.67553983 |
| 62 | phosphatidylethanolamine metabolic process (GO:0046337) | 4.65659642 |
| 63 | single strand break repair (GO:0000012) | 4.60140518 |
| 64 | chromosome organization involved in meiosis (GO:0070192) | 4.50649484 |
| 65 | UV protection (GO:0009650) | 4.49836215 |
| 66 | purinergic receptor signaling pathway (GO:0035587) | 4.48490146 |
| 67 | regulation of skeletal muscle contraction (GO:0014819) | 4.45531909 |
| 68 | male meiosis I (GO:0007141) | 4.43459509 |
| 69 | chaperone-mediated protein complex assembly (GO:0051131) | 4.42664254 |
| 70 | DNA replication checkpoint (GO:0000076) | 4.34766271 |
| 71 | histone phosphorylation (GO:0016572) | 4.34098455 |
| 72 | melanin biosynthetic process (GO:0042438) | 4.30787984 |
| 73 | left/right pattern formation (GO:0060972) | 4.25623654 |
| 74 | multicellular organismal development (GO:0007275) | 4.12944848 |
| 75 | behavioral response to nicotine (GO:0035095) | 4.06678396 |
| 76 | DNA methylation involved in gamete generation (GO:0043046) | 4.00999819 |
| 77 | sequestering of actin monomers (GO:0042989) | 3.98930935 |
| 78 | melanin metabolic process (GO:0006582) | 3.97899625 |
| 79 | meiotic nuclear division (GO:0007126) | 3.87165324 |
| 80 | sialylation (GO:0097503) | 3.86558256 |
| 81 | centriole assembly (GO:0098534) | 3.86557108 |
| 82 | gonadal mesoderm development (GO:0007506) | 3.85444626 |
| 83 | neuromuscular synaptic transmission (GO:0007274) | 3.85126142 |
| 84 | negative regulation of Rho protein signal transduction (GO:0035024) | 3.83523977 |
| 85 | cranial nerve morphogenesis (GO:0021602) | 3.78809370 |
| 86 | response to pheromone (GO:0019236) | 3.78272412 |
| 87 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.74794116 |
| 88 | urogenital system development (GO:0001655) | 3.73407983 |
| 89 | multicellular organismal movement (GO:0050879) | 3.68730925 |
| 90 | musculoskeletal movement (GO:0050881) | 3.68730925 |
| 91 | grooming behavior (GO:0007625) | 3.56773121 |
| 92 | RNA methylation (GO:0001510) | 3.56630849 |
| 93 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.55629831 |
| 94 | G-protein coupled purinergic receptor signaling pathway (GO:0035588) | 3.54882858 |
| 95 | tRNA modification (GO:0006400) | 3.53263397 |
| 96 | regulation of spindle checkpoint (GO:0090231) | 3.52937687 |
| 97 | microtubule polymerization or depolymerization (GO:0031109) | 3.51839645 |
| 98 | meiosis I (GO:0007127) | 3.51524976 |
| 99 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 3.51237756 |
| 100 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 3.51237756 |
| 101 | secondary metabolite biosynthetic process (GO:0044550) | 3.48519909 |
| 102 | protein K11-linked deubiquitination (GO:0035871) | 3.47853879 |
| 103 | protein polyglutamylation (GO:0018095) | 3.43612131 |
| 104 | positive regulation of catecholamine secretion (GO:0033605) | 3.41153721 |
| 105 | protein refolding (GO:0042026) | 3.37451506 |
| 106 | positive regulation of macrophage activation (GO:0043032) | 3.35652211 |
| 107 | nucleoside transport (GO:0015858) | 3.31804770 |
| 108 | genitalia morphogenesis (GO:0035112) | 3.30756843 |
| 109 | interferon-gamma secretion (GO:0072643) | 3.26184402 |
| 110 | cellular ketone body metabolic process (GO:0046950) | 3.24688193 |
| 111 | polyamine biosynthetic process (GO:0006596) | 3.24152043 |
| 112 | nucleotide-sugar biosynthetic process (GO:0009226) | 3.23475910 |
| 113 | regulation of Rab GTPase activity (GO:0032313) | 3.22827601 |
| 114 | positive regulation of Rab GTPase activity (GO:0032851) | 3.22827601 |
| 115 | RNA destabilization (GO:0050779) | 3.22262379 |
| 116 | nucleus organization (GO:0006997) | 3.21909006 |
| 117 | glycolytic process (GO:0006096) | 3.18360227 |
| 118 | amino-acid betaine transport (GO:0015838) | 3.17889498 |
| 119 | carnitine transport (GO:0015879) | 3.17889498 |
| 120 | regulation of synapse structural plasticity (GO:0051823) | 3.17127014 |
| 121 | protein localization to Golgi apparatus (GO:0034067) | 3.16484536 |
| 122 | establishment of protein localization to Golgi (GO:0072600) | 3.15128176 |
| 123 | RNA localization (GO:0006403) | 3.14852476 |
| 124 | purine nucleoside bisphosphate biosynthetic process (GO:0034033) | 3.14117031 |
| 125 | ribonucleoside bisphosphate biosynthetic process (GO:0034030) | 3.14117031 |
| 126 | nucleoside bisphosphate biosynthetic process (GO:0033866) | 3.14117031 |
| 127 | mitotic sister chromatid cohesion (GO:0007064) | 3.13663724 |
| 128 | chromatin silencing (GO:0006342) | 3.07260430 |
| 129 | meiotic cell cycle (GO:0051321) | 3.06624129 |
| 130 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 3.01713313 |
| 131 | protein targeting to Golgi (GO:0000042) | 2.98900879 |
| 132 | peptidyl-glutamic acid carboxylation (GO:0017187) | 2.97320497 |
| 133 | protein carboxylation (GO:0018214) | 2.97320497 |
| 134 | carnitine transmembrane transport (GO:1902603) | 2.96484164 |
| 135 | DNA conformation change (GO:0071103) | 2.96371035 |
| 136 | polyol catabolic process (GO:0046174) | 2.92638222 |
| 137 | nucleoside diphosphate phosphorylation (GO:0006165) | 2.91817318 |
| 138 | regulation of cell aging (GO:0090342) | 2.90893654 |
| 139 | protein localization to cilium (GO:0061512) | 2.87580563 |
| 140 | mitochondrion degradation (GO:0000422) | 2.87522052 |
| 141 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.87379572 |
| 142 | negative regulation of gene expression, epigenetic (GO:0045814) | 2.85984792 |
| 143 | alditol metabolic process (GO:0019400) | 2.84938113 |
| 144 | reciprocal meiotic recombination (GO:0007131) | 2.84774140 |
| 145 | reciprocal DNA recombination (GO:0035825) | 2.84774140 |
| 146 | regulation of cilium assembly (GO:1902017) | 2.84585521 |
| 147 | membrane protein intracellular domain proteolysis (GO:0031293) | 2.71532461 |
| 148 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.60918406 |
| 149 | GTP biosynthetic process (GO:0006183) | 2.60300788 |
| 150 | meiotic cell cycle process (GO:1903046) | 2.58605789 |
| 151 | cilium organization (GO:0044782) | 2.56251699 |
| 152 | nucleosome disassembly (GO:0006337) | 2.53464819 |
| 153 | protein-DNA complex disassembly (GO:0032986) | 2.53464819 |
| 154 | positive regulation of glycolytic process (GO:0045821) | 2.53337566 |
| 155 | cilium morphogenesis (GO:0060271) | 2.53153833 |
| 156 | synapsis (GO:0007129) | 2.51064896 |
| 157 | cellular component assembly involved in morphogenesis (GO:0010927) | 2.50956645 |
| 158 | microtubule-based movement (GO:0007018) | 2.48843112 |
| 159 | cilium assembly (GO:0042384) | 2.46635226 |
| 160 | peptidyl-glutamic acid modification (GO:0018200) | 2.44326051 |
| 161 | axoneme assembly (GO:0035082) | 2.39775487 |
| 162 | protein depolymerization (GO:0051261) | 2.35885339 |
| 163 | sperm motility (GO:0030317) | 14.4363981 |
| 164 | cell wall macromolecule metabolic process (GO:0044036) | 13.8618539 |
| 165 | cell wall macromolecule catabolic process (GO:0016998) | 13.8618539 |
| 166 | acrosome reaction (GO:0007340) | 13.0208491 |
| 167 | fusion of sperm to egg plasma membrane (GO:0007342) | 12.6228304 |
| 168 | acrosome assembly (GO:0001675) | 11.6546909 |
| 169 | sperm-egg recognition (GO:0035036) | 11.6503863 |
| 170 | rRNA methylation (GO:0031167) | 10.6964652 |
| 171 | binding of sperm to zona pellucida (GO:0007339) | 10.6406871 |
| 172 | cell-cell recognition (GO:0009988) | 10.4298242 |
| 173 | multicellular organism reproduction (GO:0032504) | 10.2154127 |
| 174 | spermatid development (GO:0007286) | 10.0058871 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 8.76922326 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.19496349 |
| 3 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 3.56666494 |
| 4 | * VDR_21846776_ChIP-Seq_THP-1_Human | 3.48689102 |
| 5 | LXR_22292898_ChIP-Seq_THP-1_Human | 3.25375301 |
| 6 | * P68_20966046_ChIP-Seq_HELA_Human | 3.19747108 |
| 7 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 3.05148823 |
| 8 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.98374199 |
| 9 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.93573922 |
| 10 | * CTCF_27219007_Chip-Seq_Bcells_Human | 2.72822862 |
| 11 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.69803599 |
| 12 | VDR_22108803_ChIP-Seq_LS180_Human | 2.65990879 |
| 13 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.51904353 |
| 14 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 2.41908695 |
| 15 | * MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 2.32680389 |
| 16 | * E2F1_20622854_ChIP-Seq_HELA_Human | 2.32431118 |
| 17 | * SMC4_20622854_ChIP-Seq_HELA_Human | 2.31887868 |
| 18 | * MAF_26560356_Chip-Seq_TH2_Human | 2.29575206 |
| 19 | * PHF8_20622854_ChIP-Seq_HELA_Human | 2.27481809 |
| 20 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.26223881 |
| 21 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 2.25607190 |
| 22 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.25301349 |
| 23 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.22054304 |
| 24 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 2.14438388 |
| 25 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.09222686 |
| 26 | * SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 2.03451345 |
| 27 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.00778711 |
| 28 | ERA_21632823_ChIP-Seq_H3396_Human | 1.98783087 |
| 29 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.97264301 |
| 30 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.96260246 |
| 31 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.87055293 |
| 32 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.85666852 |
| 33 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 1.84280633 |
| 34 | * VDR_24763502_ChIP-Seq_THP-1_Human | 1.81972854 |
| 35 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.81892835 |
| 36 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.80486575 |
| 37 | * EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.78864293 |
| 38 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.77763500 |
| 39 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 1.77522644 |
| 40 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.76065187 |
| 41 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.75387938 |
| 42 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.74736051 |
| 43 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 1.73031781 |
| 44 | STAT1_17558387_ChIP-Seq_HELA_Human | 1.72829250 |
| 45 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.72764402 |
| 46 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.69727745 |
| 47 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.69305296 |
| 48 | * MAF_26560356_Chip-Seq_TH1_Human | 1.68642645 |
| 49 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 1.68239994 |
| 50 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.68000684 |
| 51 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.67062330 |
| 52 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.66699574 |
| 53 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.61320572 |
| 54 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.60903754 |
| 55 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.60277581 |
| 56 | * XRN2_22483619_ChIP-Seq_HELA_Human | 1.59737242 |
| 57 | MYC_22102868_ChIP-Seq_BL_Human | 1.58358174 |
| 58 | FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.58063909 |
| 59 | P300_27268052_Chip-Seq_Bcells_Human | 1.57118599 |
| 60 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.55302533 |
| 61 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.53024541 |
| 62 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.52144107 |
| 63 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.52056401 |
| 64 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.51861396 |
| 65 | * SA1_27219007_Chip-Seq_Bcells_Human | 1.51298606 |
| 66 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.50311691 |
| 67 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.48248191 |
| 68 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.44928586 |
| 69 | P53_21459846_ChIP-Seq_SAOS-2_Human | 1.44063981 |
| 70 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.41207049 |
| 71 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 1.40706883 |
| 72 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.40668155 |
| 73 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.39389658 |
| 74 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.38541760 |
| 75 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.37763700 |
| 76 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.37219111 |
| 77 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.36575774 |
| 78 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.36325880 |
| 79 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.35528176 |
| 80 | * KDM2B_26808549_Chip-Seq_REH_Human | 1.35396287 |
| 81 | ETS1_21867929_ChIP-Seq_TH2_Mouse | 1.34983907 |
| 82 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.34926597 |
| 83 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.34926597 |
| 84 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 1.34556654 |
| 85 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.34217348 |
| 86 | * NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 1.33042215 |
| 87 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.32865043 |
| 88 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.32401889 |
| 89 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.32043188 |
| 90 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.30949271 |
| 91 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 1.30679972 |
| 92 | GF1_26923725_Chip-Seq_HPCs_Mouse | 1.28328400 |
| 93 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.27409538 |
| 94 | SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.27206751 |
| 95 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.26658805 |
| 96 | * RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.26320784 |
| 97 | GATA3_21867929_ChIP-Seq_TH1_Mouse | 1.26040442 |
| 98 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.25679595 |
| 99 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.24991242 |
| 100 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.24749376 |
| 101 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.24243594 |
| 102 | UTX_26944678_Chip-Seq_JUKART_Human | 1.23775572 |
| 103 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.23600444 |
| 104 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 1.23322494 |
| 105 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.23094757 |
| 106 | CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.23061430 |
| 107 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.22283709 |
| 108 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.22022782 |
| 109 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 1.21289653 |
| 110 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.20967665 |
| 111 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.20145908 |
| 112 | * OCT4_19829295_ChIP-Seq_ESCs_Human | 1.20108610 |
| 113 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.20001406 |
| 114 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.18990869 |
| 115 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.18440581 |
| 116 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.18092672 |
| 117 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 1.17183643 |
| 118 | KDM2B_26808549_Chip-Seq_K562_Human | 1.16368880 |
| 119 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 1.16195326 |
| 120 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.15922295 |
| 121 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15367021 |
| 122 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.15271584 |
| 123 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.15027111 |
| 124 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.13389959 |
| 125 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.13355855 |
| 126 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11848135 |
| 127 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.11848135 |
| 128 | * MYC_27129775_Chip-Seq_CORNEA_Mouse | 1.11839031 |
| 129 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.11687052 |
| 130 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 1.11664965 |
| 131 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 1.11429088 |
| 132 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.11280101 |
| 133 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.11140006 |
| 134 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10484891 |
| 135 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 1.10415786 |
| 136 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.10064833 |
| 137 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.10049912 |
| 138 | * GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.09737805 |
| 139 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 1.09370613 |
| 140 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.09172461 |
| 141 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.09110360 |
| 142 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.08809078 |
| 143 | GATA1_19941826_ChIP-Seq_K562_Human | 1.08528626 |
| 144 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.07921766 |
| 145 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 1.07378694 |
| 146 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.07110586 |
| 147 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.06929664 |
| 148 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.06406661 |
| 149 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.05417046 |
| 150 | ATF3_27146783_Chip-Seq_COLON_Human | 1.03887260 |
| 151 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 1.03787660 |
| 152 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.02773628 |
| 153 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.01629053 |
| 154 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 1.01271865 |
| 155 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.00934156 |
| 156 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.00166383 |
| 157 | LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.99962445 |
| 158 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.99777170 |
| 159 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.99703859 |
| 160 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.97371953 |
| 161 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.97164214 |
| 162 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.94758707 |
| 163 | * BCOR_27268052_Chip-Seq_Bcells_Human | 0.94649449 |
| 164 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.94120357 |
| 165 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.92944163 |
| 166 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.92783990 |
| 167 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.92452581 |
| 168 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.91643456 |
| 169 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.90801684 |
| 170 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.90445436 |
| 171 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.90271868 |
| 172 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.89847684 |
| 173 | * FLI1_21867929_ChIP-Seq_CD8_Mouse | 0.88152987 |
| 174 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.86474557 |
| 175 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 0.85724246 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003136_yellow_coat_color | 6.72926189 |
| 2 | MP0001986_abnormal_taste_sensitivity | 6.55801237 |
| 3 | MP0005423_abnormal_somatic_nervous | 6.38041709 |
| 4 | MP0005171_absent_coat_pigmentation | 6.29924654 |
| 5 | MP0003698_abnormal_male_reproductive | 6.01342151 |
| 6 | MP0005174_abnormal_tail_pigmentation | 5.91459658 |
| 7 | MP0001929_abnormal_gametogenesis | 5.50028661 |
| 8 | MP0005409_darkened_coat_color | 4.20351819 |
| 9 | MP0001188_hyperpigmentation | 4.06795788 |
| 10 | MP0008877_abnormal_DNA_methylation | 3.54514019 |
| 11 | MP0005670_abnormal_white_adipose | 3.31026056 |
| 12 | MP0002161_abnormal_fertility/fecundity | 3.28512959 |
| 13 | MP0002210_abnormal_sex_determination | 3.17634334 |
| 14 | MP0001145_abnormal_male_reproductive | 2.70377773 |
| 15 | MP0005083_abnormal_biliary_tract | 2.58836194 |
| 16 | MP0000015_abnormal_ear_pigmentation | 2.43999950 |
| 17 | MP0004381_abnormal_hair_follicle | 2.42164610 |
| 18 | MP0000653_abnormal_sex_gland | 2.32948212 |
| 19 | MP0002638_abnormal_pupillary_reflex | 2.02653731 |
| 20 | MP0005410_abnormal_fertilization | 16.9325890 |
| 21 | MP0001756_abnormal_urination | 1.86732056 |
| 22 | MP0002653_abnormal_ependyma_morphology | 1.83830063 |
| 23 | MP0004233_abnormal_muscle_weight | 1.66082687 |
| 24 | MP0010386_abnormal_urinary_bladder | 1.63610583 |
| 25 | MP0003646_muscle_fatigue | 1.59827885 |
| 26 | MP0001348_abnormal_lacrimal_gland | 1.59314898 |
| 27 | MP0002735_abnormal_chemical_nociception | 1.55957716 |
| 28 | MP0000538_abnormal_urinary_bladder | 1.47442939 |
| 29 | MP0001502_abnormal_circadian_rhythm | 1.45766932 |
| 30 | MP0003693_abnormal_embryo_hatching | 1.45485545 |
| 31 | MP0000003_abnormal_adipose_tissue | 1.39993801 |
| 32 | MP0002160_abnormal_reproductive_system | 1.37060865 |
| 33 | MP0000013_abnormal_adipose_tissue | 1.30366604 |
| 34 | MP0005076_abnormal_cell_differentiation | 1.26983798 |
| 35 | MP0002234_abnormal_pharynx_morphology | 1.21773114 |
| 36 | MP0003705_abnormal_hypodermis_morpholog | 1.17975643 |
| 37 | MP0004957_abnormal_blastocyst_morpholog | 1.12770562 |
| 38 | MP0001984_abnormal_olfaction | 1.09918717 |
| 39 | MP0005623_abnormal_meninges_morphology | 1.09739947 |
| 40 | MP0001765_abnormal_ion_homeostasis | 1.07219553 |
| 41 | MP0000678_abnormal_parathyroid_gland | 1.06183795 |
| 42 | MP0005332_abnormal_amino_acid | 1.03833406 |
| 43 | MP0003453_abnormal_keratinocyte_physiol | 0.98220256 |
| 44 | MP0004130_abnormal_muscle_cell | 0.96350863 |
| 45 | MP0002282_abnormal_trachea_morphology | 0.95794322 |
| 46 | MP0003077_abnormal_cell_cycle | 0.95200405 |
| 47 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.93961212 |
| 48 | MP0005084_abnormal_gallbladder_morpholo | 0.92909605 |
| 49 | MP0003091_abnormal_cell_migration | 0.84794106 |
| 50 | MP0001873_stomach_inflammation | 0.76078794 |
| 51 | MP0003115_abnormal_respiratory_system | 0.75109418 |
| 52 | MP0000750_abnormal_muscle_regeneration | 0.73812640 |
| 53 | MP0005647_abnormal_sex_gland | 0.71048668 |
| 54 | MP0003011_delayed_dark_adaptation | 0.70032408 |
| 55 | MP0002249_abnormal_larynx_morphology | 0.69803738 |
| 56 | MP0003329_amyloid_beta_deposits | 0.68454443 |
| 57 | MP0009053_abnormal_anal_canal | 0.68390833 |
| 58 | MP0001664_abnormal_digestion | 0.66849392 |
| 59 | MP0009046_muscle_twitch | 0.66271789 |
| 60 | MP0005666_abnormal_adipose_tissue | 0.65235795 |
| 61 | MP0005389_reproductive_system_phenotype | 0.63783289 |
| 62 | MP0003632_abnormal_nervous_system | 0.63533738 |
| 63 | MP0002075_abnormal_coat/hair_pigmentati | 0.63470385 |
| 64 | MP0002736_abnormal_nociception_after | 0.63334716 |
| 65 | MP0008995_early_reproductive_senescence | 0.61142195 |
| 66 | MP0005636_abnormal_mineral_homeostasis | 0.60910072 |
| 67 | MP0008058_abnormal_DNA_repair | 0.60330823 |
| 68 | MP0003718_maternal_effect | 0.58645021 |
| 69 | MP0001970_abnormal_pain_threshold | 0.56592236 |
| 70 | MP0004036_abnormal_muscle_relaxation | 0.54495786 |
| 71 | MP0002019_abnormal_tumor_incidence | 0.54067728 |
| 72 | MP0002269_muscular_atrophy | 0.53792111 |
| 73 | MP0000367_abnormal_coat/_hair | 0.53600551 |
| 74 | MP0001958_emphysema | 0.51569239 |
| 75 | MP0005377_hearing/vestibular/ear_phenot | 0.51397876 |
| 76 | MP0003878_abnormal_ear_physiology | 0.51397876 |
| 77 | MP0001764_abnormal_homeostasis | 0.51183069 |
| 78 | MP0000371_diluted_coat_color | 0.49482214 |
| 79 | MP0001324_abnormal_eye_pigmentation | 0.47511197 |
| 80 | MP0000534_abnormal_ureter_morphology | 0.47429350 |
| 81 | MP0005220_abnormal_exocrine_pancreas | 0.47064575 |
| 82 | MP0001905_abnormal_dopamine_level | 0.46954016 |
| 83 | MP0003448_altered_tumor_morphology | 0.45932927 |
| 84 | MP0000470_abnormal_stomach_morphology | 0.45786889 |
| 85 | MP0003137_abnormal_impulse_conducting | 0.44388205 |
| 86 | MP0006036_abnormal_mitochondrial_physio | 0.44130723 |
| 87 | MP0002136_abnormal_kidney_physiology | 0.43671141 |
| 88 | MP0002933_joint_inflammation | 0.42575076 |
| 89 | MP0003699_abnormal_female_reproductive | 0.42299217 |
| 90 | MP0000026_abnormal_inner_ear | 0.41714073 |
| 91 | MP0005451_abnormal_body_composition | 0.41057371 |
| 92 | MP0005085_abnormal_gallbladder_physiolo | 0.40597330 |
| 93 | MP0000358_abnormal_cell_content/ | 0.39925787 |
| 94 | MP0001293_anophthalmia | 0.39601263 |
| 95 | MP0001968_abnormal_touch/_nociception | 0.38015160 |
| 96 | MP0009115_abnormal_fat_cell | 0.37924413 |
| 97 | MP0005397_hematopoietic_system_phenotyp | 0.36737857 |
| 98 | MP0001545_abnormal_hematopoietic_system | 0.36737857 |
| 99 | MP0009278_abnormal_bone_marrow | 0.36256594 |
| 100 | MP0000604_amyloidosis | 0.36228490 |
| 101 | MP0008057_abnormal_DNA_replication | 0.35788186 |
| 102 | MP0000747_muscle_weakness | 0.35442653 |
| 103 | MP0005253_abnormal_eye_physiology | 0.35347977 |
| 104 | MP0009931_abnormal_skin_appearance | 0.35059331 |
| 105 | MP0002928_abnormal_bile_duct | 0.35005265 |
| 106 | MP0002139_abnormal_hepatobiliary_system | 0.34484274 |
| 107 | MP0005551_abnormal_eye_electrophysiolog | 0.34191556 |
| 108 | MP0002132_abnormal_respiratory_system | 0.34118518 |
| 109 | MP0004133_heterotaxia | 0.33613019 |
| 110 | MP0009643_abnormal_urine_homeostasis | 0.33346578 |
| 111 | MP0001963_abnormal_hearing_physiology | 0.33183547 |
| 112 | MP0003942_abnormal_urinary_system | 0.33013002 |
| 113 | MP0010771_integument_phenotype | 0.32376684 |
| 114 | MP0004811_abnormal_neuron_physiology | 0.32130940 |
| 115 | MP0001186_pigmentation_phenotype | 0.30794554 |
| 116 | MP0004197_abnormal_fetal_growth/weight/ | 0.30519490 |
| 117 | MP0003943_abnormal_hepatobiliary_system | 0.30474384 |
| 118 | MP0008770_decreased_survivor_rate | 0.30472943 |
| 119 | MP0000569_abnormal_digit_pigmentation | 0.29991929 |
| 120 | MP0003633_abnormal_nervous_system | 0.29977716 |
| 121 | MP0002095_abnormal_skin_pigmentation | 0.29113590 |
| 122 | MP0008007_abnormal_cellular_replicative | 0.28872954 |
| 123 | MP0003950_abnormal_plasma_membrane | 0.28373472 |
| 124 | MP0002971_abnormal_brown_adipose | 0.27732488 |
| 125 | MP0005391_vision/eye_phenotype | 0.26094646 |
| 126 | MP0002169_no_abnormal_phenotype | 0.25310913 |
| 127 | MP0003879_abnormal_hair_cell | 0.25112631 |
| 128 | MP0002873_normal_phenotype | 0.25090993 |
| 129 | MP0003948_abnormal_gas_homeostasis | 0.25077274 |
| 130 | MP0003631_nervous_system_phenotype | 0.24711514 |
| 131 | MP0001730_embryonic_growth_arrest | 0.24187129 |
| 132 | MP0003861_abnormal_nervous_system | 0.23965545 |
| 133 | MP0004742_abnormal_vestibular_system | 0.23471320 |
| 134 | MP0002152_abnormal_brain_morphology | 0.22801747 |
| 135 | MP0005375_adipose_tissue_phenotype | 0.22206105 |
| 136 | MP0002102_abnormal_ear_morphology | 0.22107740 |
| 137 | MP0001849_ear_inflammation | 0.21472546 |
| 138 | MP0002295_abnormal_pulmonary_circulatio | 0.21247497 |
| 139 | MP0002909_abnormal_adrenal_gland | 0.20527281 |
| 140 | MP0010094_abnormal_chromosome_stability | 0.20496482 |
| 141 | MP0004270_analgesia | 0.20185318 |
| 142 | MP0004019_abnormal_vitamin_homeostasis | 0.19685584 |
| 143 | MP0008875_abnormal_xenobiotic_pharmacok | 0.19433315 |
| 144 | MP0004145_abnormal_muscle_electrophysio | 0.19138729 |
| 145 | MP0008961_abnormal_basal_metabolism | 0.18900200 |
| 146 | MP0006035_abnormal_mitochondrial_morpho | 0.18879123 |
| 147 | MP0003787_abnormal_imprinting | 0.18697845 |
| 148 | MP0003111_abnormal_nucleus_morphology | 0.18405578 |
| 149 | MP0008569_lethality_at_weaning | 0.18322110 |
| 150 | MP0004043_abnormal_pH_regulation | 0.18154192 |
| 151 | MP0005365_abnormal_bile_salt | 0.17531608 |
| 152 | MP0000751_myopathy | 0.17107731 |
| 153 | MP0001119_abnormal_female_reproductive | 0.16439607 |
| 154 | MP0000462_abnormal_digestive_system | 0.16385557 |
| 155 | MP0003959_abnormal_lean_body | 0.15443522 |
| 156 | MP0002118_abnormal_lipid_homeostasis | 0.15205522 |
| 157 | MP0000001_mammalian_phenotype | 0.14896580 |
| 158 | MP0005503_abnormal_tendon_morphology | 0.14643621 |
| 159 | MP0002693_abnormal_pancreas_physiology | 0.14366272 |
| 160 | MP0002229_neurodegeneration | 0.13748443 |
| 161 | MP0002822_catalepsy | 0.13734267 |
| 162 | MP0001270_distended_abdomen | 0.13004953 |
| 163 | MP0002092_abnormal_eye_morphology | 0.12866913 |
| 164 | MP0005319_abnormal_enzyme/_coenzyme | 0.12702731 |
| 165 | MP0005535_abnormal_body_temperature | 0.12488927 |
| 166 | MP0000920_abnormal_myelination | 0.12429007 |
| 167 | MP0001661_extended_life_span | 0.12364699 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal respiratory epithelium morphology (HP:0012253) | 9.28104105 |
| 2 | Abnormal respiratory motile cilium morphology (HP:0005938) | 9.28104105 |
| 3 | Abnormal respiratory motile cilium physiology (HP:0012261) | 9.26629848 |
| 4 | Chronic bronchitis (HP:0004469) | 7.42577035 |
| 5 | Rhinitis (HP:0012384) | 7.35681646 |
| 6 | Infertility (HP:0000789) | 7.31219713 |
| 7 | Abnormal ciliary motility (HP:0012262) | 7.07256150 |
| 8 | Nasal polyposis (HP:0100582) | 6.47133052 |
| 9 | Rib fusion (HP:0000902) | 5.88658702 |
| 10 | Intestinal fistula (HP:0100819) | 5.83216596 |
| 11 | Rectovaginal fistula (HP:0000143) | 5.77242673 |
| 12 | Rectal fistula (HP:0100590) | 5.77242673 |
| 13 | Attenuation of retinal blood vessels (HP:0007843) | 5.49038243 |
| 14 | Abnormality of the nasal mucosa (HP:0000433) | 5.32448610 |
| 15 | Vaginal fistula (HP:0004320) | 5.26348706 |
| 16 | Male infertility (HP:0003251) | 5.05044628 |
| 17 | Poikiloderma (HP:0001029) | 4.98267743 |
| 18 | Bony spicule pigmentary retinopathy (HP:0007737) | 4.98091230 |
| 19 | Ulnar bowing (HP:0003031) | 4.97620427 |
| 20 | Congenital stationary night blindness (HP:0007642) | 4.77347794 |
| 21 | Annular pancreas (HP:0001734) | 4.66536705 |
| 22 | Bronchitis (HP:0012387) | 4.55982517 |
| 23 | Turricephaly (HP:0000262) | 4.52527339 |
| 24 | Thin bony cortex (HP:0002753) | 4.49089718 |
| 25 | Facial hemangioma (HP:0000329) | 4.46157358 |
| 26 | Bronchiectasis (HP:0002110) | 4.34364152 |
| 27 | Testicular atrophy (HP:0000029) | 4.19819151 |
| 28 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 4.07963733 |
| 29 | Chorioretinal atrophy (HP:0000533) | 4.07412014 |
| 30 | Popliteal pterygium (HP:0009756) | 4.02444710 |
| 31 | Coronal craniosynostosis (HP:0004440) | 3.94513152 |
| 32 | Nephronophthisis (HP:0000090) | 3.84397804 |
| 33 | Abnormal spermatogenesis (HP:0008669) | 3.79878160 |
| 34 | Short chin (HP:0000331) | 3.77985875 |
| 35 | Enlarged epiphyses (HP:0010580) | 3.52973945 |
| 36 | Aplasia of the musculature (HP:0100854) | 3.45138026 |
| 37 | Patellar aplasia (HP:0006443) | 3.44632135 |
| 38 | Fetal akinesia sequence (HP:0001989) | 3.41154158 |
| 39 | Birth length less than 3rd percentile (HP:0003561) | 3.40411914 |
| 40 | Squamous cell carcinoma (HP:0002860) | 3.39431928 |
| 41 | Anteriorly placed anus (HP:0001545) | 3.35923137 |
| 42 | Abnormality of the costochondral junction (HP:0000919) | 3.33974859 |
| 43 | Recurrent otitis media (HP:0000403) | 3.26686079 |
| 44 | Abnormality of the intrinsic pathway (HP:0010989) | 3.19736881 |
| 45 | Delayed epiphyseal ossification (HP:0002663) | 3.14696545 |
| 46 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.14528207 |
| 47 | Akinesia (HP:0002304) | 3.10881005 |
| 48 | Recurrent sinusitis (HP:0011108) | 3.06835776 |
| 49 | Absent thumb (HP:0009777) | 2.93809660 |
| 50 | Pendular nystagmus (HP:0012043) | 2.87063675 |
| 51 | Abnormality of the renal medulla (HP:0100957) | 2.85340447 |
| 52 | Severe visual impairment (HP:0001141) | 2.84950933 |
| 53 | Chronic hepatic failure (HP:0100626) | 2.82667868 |
| 54 | Widely patent fontanelles and sutures (HP:0004492) | 2.81842258 |
| 55 | Impulsivity (HP:0100710) | 2.80015232 |
| 56 | Cholecystitis (HP:0001082) | 2.75433139 |
| 57 | Abnormal gallbladder physiology (HP:0012438) | 2.75433139 |
| 58 | Abnormality of the hepatic vasculature (HP:0006707) | 2.74936721 |
| 59 | Hypophosphatemic rickets (HP:0004912) | 2.73446891 |
| 60 | Hypoalbuminemia (HP:0003073) | 2.70953993 |
| 61 | Abnormal albumin level (HP:0012116) | 2.70953993 |
| 62 | Amniotic constriction ring (HP:0009775) | 2.65268493 |
| 63 | Abnormality of placental membranes (HP:0011409) | 2.65268493 |
| 64 | Increased number of teeth (HP:0011069) | 2.65083601 |
| 65 | Recurrent bronchitis (HP:0002837) | 2.64919506 |
| 66 | Capillary hemangiomas (HP:0005306) | 2.62497819 |
| 67 | Abnormality of homocysteine metabolism (HP:0010919) | 2.62152140 |
| 68 | Homocystinuria (HP:0002156) | 2.62152140 |
| 69 | Absent radius (HP:0003974) | 2.61810786 |
| 70 | Tubulointerstitial nephritis (HP:0001970) | 2.54042689 |
| 71 | Bowed forearm bones (HP:0003956) | 2.51080394 |
| 72 | Bowing of the arm (HP:0006488) | 2.51080394 |
| 73 | Facial diplegia (HP:0001349) | 2.49185324 |
| 74 | Tubular atrophy (HP:0000092) | 2.47599305 |
| 75 | Breast hypoplasia (HP:0003187) | 2.43871481 |
| 76 | Aplasia involving forearm bones (HP:0009822) | 2.43766682 |
| 77 | Absent forearm bone (HP:0003953) | 2.43766682 |
| 78 | Choanal stenosis (HP:0000452) | 2.43294920 |
| 79 | Short humerus (HP:0005792) | 2.42531542 |
| 80 | Flat occiput (HP:0005469) | 2.37105603 |
| 81 | Abnormality of midbrain morphology (HP:0002418) | 2.36669772 |
| 82 | Molar tooth sign on MRI (HP:0002419) | 2.36669772 |
| 83 | Premature graying of hair (HP:0002216) | 2.36664051 |
| 84 | Medial flaring of the eyebrow (HP:0010747) | 2.34349031 |
| 85 | Dyschromatopsia (HP:0007641) | 2.33893774 |
| 86 | Azoospermia (HP:0000027) | 2.33868422 |
| 87 | Tubulointerstitial abnormality (HP:0001969) | 2.30081406 |
| 88 | Polyuria (HP:0000103) | 2.29822347 |
| 89 | Narrow nasal bridge (HP:0000446) | 2.28084940 |
| 90 | Joint stiffness (HP:0001387) | 2.27506753 |
| 91 | Decreased circulating renin level (HP:0003351) | 2.26199328 |
| 92 | Choroideremia (HP:0001139) | 2.23752165 |
| 93 | Short thumb (HP:0009778) | 2.19505195 |
| 94 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.19049618 |
| 95 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.16944875 |
| 96 | Gonadotropin excess (HP:0000837) | 2.16881917 |
| 97 | Reduced antithrombin III activity (HP:0001976) | 2.15032361 |
| 98 | Congenital malformation of the right heart (HP:0011723) | 2.13138263 |
| 99 | Double outlet right ventricle (HP:0001719) | 2.13138263 |
| 100 | Prolonged partial thromboplastin time (HP:0003645) | 2.11360460 |
| 101 | Hypoplasia of the pons (HP:0012110) | 2.09609965 |
| 102 | Basal cell carcinoma (HP:0002671) | 2.07475467 |
| 103 | Malignant hyperthermia (HP:0002047) | 2.07242533 |
| 104 | Decreased central vision (HP:0007663) | 2.06402294 |
| 105 | Spastic tetraparesis (HP:0001285) | 2.05559120 |
| 106 | Thin ribs (HP:0000883) | 2.00745779 |
| 107 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 13.4162318 |
| 108 | Absent/shortened dynein arms (HP:0200106) | 13.4162318 |
| 109 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 12.8451146 |
| 110 | Tubulointerstitial fibrosis (HP:0005576) | 1.96937440 |
| 111 | Neurofibrillary tangles (HP:0002185) | 1.92260001 |
| 112 | Hemorrhage of the eye (HP:0011885) | 1.91095851 |
| 113 | Hyperkalemia (HP:0002153) | 1.87712258 |
| 114 | Abnormality of the pons (HP:0007361) | 1.85297440 |
| 115 | Generalized aminoaciduria (HP:0002909) | 1.79386022 |
| 116 | Bifid uvula (HP:0000193) | 1.77350165 |
| 117 | Atrioventricular block (HP:0001678) | 1.75580067 |
| 118 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.75014039 |
| 119 | Abnormality of the nasal septum (HP:0000419) | 1.74582737 |
| 120 | Joint hemorrhage (HP:0005261) | 1.74534974 |
| 121 | Muscle fiber atrophy (HP:0100295) | 1.74276782 |
| 122 | Small hand (HP:0200055) | 1.74204199 |
| 123 | Hypoalphalipoproteinemia (HP:0003233) | 1.73999876 |
| 124 | Abnormality of the fingertips (HP:0001211) | 1.71687913 |
| 125 | Polydipsia (HP:0001959) | 1.71357628 |
| 126 | Abnormal drinking behavior (HP:0030082) | 1.71357628 |
| 127 | Heterotopia (HP:0002282) | 1.68563101 |
| 128 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.64495335 |
| 129 | Exercise-induced myalgia (HP:0003738) | 1.64306162 |
| 130 | Stage 5 chronic kidney disease (HP:0003774) | 1.62942293 |
| 131 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.60841233 |
| 132 | Easy fatigability (HP:0003388) | 1.59862431 |
| 133 | Abnormality of renal excretion (HP:0011036) | 1.58894632 |
| 134 | Cerebral inclusion bodies (HP:0100314) | 1.58031772 |
| 135 | Abnormal biliary tract physiology (HP:0012439) | 1.56676645 |
| 136 | Bile duct proliferation (HP:0001408) | 1.56676645 |
| 137 | Postaxial foot polydactyly (HP:0001830) | 1.55841252 |
| 138 | Congenital hepatic fibrosis (HP:0002612) | 1.52139920 |
| 139 | Fatigable weakness (HP:0003473) | 1.49663097 |
| 140 | Abnormality of the neuromuscular junction (HP:0003398) | 1.49663097 |
| 141 | Bundle branch block (HP:0011710) | 1.49374692 |
| 142 | Sensory axonal neuropathy (HP:0003390) | 1.48842281 |
| 143 | Myoglobinuria (HP:0002913) | 1.48821947 |
| 144 | Asymmetric septal hypertrophy (HP:0001670) | 1.47161487 |
| 145 | Bell-shaped thorax (HP:0001591) | 1.46808587 |
| 146 | Abnormality of the renal cortex (HP:0011035) | 1.43220201 |
| 147 | Loss of speech (HP:0002371) | 1.42009518 |
| 148 | Hypercholesterolemia (HP:0003124) | 1.41991079 |
| 149 | Short ribs (HP:0000773) | 1.41780752 |
| 150 | Abnormality of dentin (HP:0010299) | 1.41601235 |
| 151 | Abnormal urine output (HP:0012590) | 1.37670221 |
| 152 | Renal dysplasia (HP:0000110) | 1.35327440 |
| 153 | Oculomotor apraxia (HP:0000657) | 1.34811336 |
| 154 | Cerebellar dysplasia (HP:0007033) | 1.33602065 |
| 155 | Rhabdomyolysis (HP:0003201) | 1.33458455 |
| 156 | Neoplasm of the heart (HP:0100544) | 1.31731546 |
| 157 | Constricted visual fields (HP:0001133) | 1.31623255 |
| 158 | Postaxial hand polydactyly (HP:0001162) | 1.31536679 |
| 159 | Exercise-induced muscle cramps (HP:0003710) | 1.29268846 |
| 160 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.27682081 |
| 161 | Absent epiphyses (HP:0010577) | 1.27682081 |
| 162 | Hemiparesis (HP:0001269) | 1.27322843 |
| 163 | Abnormality of the dental pulp (HP:0006479) | 1.27164424 |
| 164 | Abnormality of the dental root (HP:0006486) | 1.26721222 |
| 165 | Taurodontia (HP:0000679) | 1.26721222 |
| 166 | Abnormality of permanent molar morphology (HP:0011071) | 1.26721222 |
| 167 | Generalized muscle weakness (HP:0003324) | 1.25809450 |
| 168 | Gait imbalance (HP:0002141) | 1.25141882 |
| 169 | Type 2 muscle fiber atrophy (HP:0003554) | 1.24690132 |
| 170 | Congenital primary aphakia (HP:0007707) | 1.24650735 |
| 171 | Chronic sinusitis (HP:0011109) | 1.24134753 |
| 172 | Deformed sella turcica (HP:0002681) | 1.23265050 |
| 173 | Facial cleft (HP:0002006) | 1.23071134 |
| 174 | Decreased muscle mass (HP:0003199) | 1.23037495 |
| 175 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.22021044 |
| 176 | Bulbar palsy (HP:0001283) | 1.21645543 |
| 177 | Retinal dysplasia (HP:0007973) | 1.20816212 |
| 178 | Short femoral neck (HP:0100864) | 1.20649222 |
| 179 | Cystic liver disease (HP:0006706) | 1.18858160 |
| 180 | Truncal obesity (HP:0001956) | 1.17303544 |
| 181 | Fibular hypoplasia (HP:0003038) | 1.16556162 |
| 182 | Abnormality of molar (HP:0011077) | 1.15844055 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PDK4 | 7.48313440 |
| 2 | PDK3 | 7.48313440 |
| 3 | TESK1 | 7.28578341 |
| 4 | PRKD3 | 5.50698410 |
| 5 | ICK | 5.11434462 |
| 6 | PDK2 | 4.82261881 |
| 7 | BLK | 3.27510590 |
| 8 | ACVR1B | 2.99905707 |
| 9 | GRK6 | 2.47723865 |
| 10 | PTK2B | 2.21980853 |
| 11 | TLK1 | 2.21978047 |
| 12 | WNK4 | 2.21477093 |
| 13 | STK39 | 2.15244493 |
| 14 | BRD4 | 2.11490035 |
| 15 | STK38 | 2.09830882 |
| 16 | SIK2 | 2.02802439 |
| 17 | BMPR1B | 1.97704909 |
| 18 | ZAK | 1.92168510 |
| 19 | MST1R | 1.87748371 |
| 20 | DYRK1B | 1.82733626 |
| 21 | DDR2 | 1.59313489 |
| 22 | NEK2 | 1.57545280 |
| 23 | INSRR | 1.56137580 |
| 24 | MAPK11 | 1.49919277 |
| 25 | PNCK | 1.47197658 |
| 26 | PDK1 | 1.36500232 |
| 27 | STK16 | 1.26025324 |
| 28 | PIM2 | 1.18511912 |
| 29 | AKT3 | 1.12295369 |
| 30 | CAMK1D | 1.09543711 |
| 31 | RPS6KA2 | 1.00510603 |
| 32 | MELK | 0.98316750 |
| 33 | PDPK1 | 0.97836091 |
| 34 | DYRK3 | 0.95956588 |
| 35 | ADRBK1 | 0.93276901 |
| 36 | RIPK4 | 0.93095657 |
| 37 | ERN1 | 0.92922911 |
| 38 | MAPK15 | 0.89046654 |
| 39 | IRAK1 | 0.87213219 |
| 40 | MAP2K3 | 0.85836398 |
| 41 | TYRO3 | 0.85125161 |
| 42 | ZAP70 | 0.84213945 |
| 43 | RPS6KA6 | 0.83344225 |
| 44 | WNK1 | 0.81870410 |
| 45 | EEF2K | 0.78983742 |
| 46 | SGK223 | 0.75567354 |
| 47 | SGK494 | 0.75567354 |
| 48 | RPS6KC1 | 0.72816075 |
| 49 | RPS6KL1 | 0.72816075 |
| 50 | SIK1 | 0.72742251 |
| 51 | TESK2 | 0.70802803 |
| 52 | TGFBR1 | 0.69236843 |
| 53 | CCNB1 | 0.67785189 |
| 54 | FRK | 0.67718690 |
| 55 | PASK | 0.65409256 |
| 56 | RAF1 | 0.62294246 |
| 57 | ADRBK2 | 0.61934439 |
| 58 | PINK1 | 0.60911296 |
| 59 | CHEK2 | 0.59625650 |
| 60 | MAP3K7 | 0.58642020 |
| 61 | STK3 | 0.58637617 |
| 62 | CDK7 | 0.56989319 |
| 63 | TTK | 0.56133480 |
| 64 | KSR2 | 0.55767531 |
| 65 | NTRK2 | 0.54948101 |
| 66 | MUSK | 0.53656313 |
| 67 | MAPK12 | 0.52404905 |
| 68 | IRAK2 | 0.48462994 |
| 69 | MAP2K6 | 0.47898017 |
| 70 | PIK3CG | 0.47150588 |
| 71 | PRKD2 | 0.46943140 |
| 72 | MAP3K10 | 0.46585189 |
| 73 | CAMK1 | 0.45467912 |
| 74 | PRKAA2 | 0.43326105 |
| 75 | PKN2 | 0.43183942 |
| 76 | PRKCG | 0.43144212 |
| 77 | CAMK1G | 0.41445193 |
| 78 | STK38L | 0.40990269 |
| 79 | PAK1 | 0.40722814 |
| 80 | LMTK2 | 0.40644546 |
| 81 | TRPM7 | 0.40212976 |
| 82 | MAPKAPK5 | 0.39747285 |
| 83 | MAP4K2 | 0.38069040 |
| 84 | RPS6KA5 | 0.37408191 |
| 85 | MAPK1 | 0.36514279 |
| 86 | MET | 0.36457396 |
| 87 | DAPK2 | 0.32922361 |
| 88 | MAP2K2 | 0.32317254 |
| 89 | PAK4 | 0.31261787 |
| 90 | CHEK1 | 0.30967040 |
| 91 | MARK2 | 0.30879550 |
| 92 | PAK2 | 0.30472267 |
| 93 | SMG1 | 0.28688532 |
| 94 | PLK2 | 0.28136939 |
| 95 | MAPK10 | 0.26616844 |
| 96 | SGK1 | 0.26525406 |
| 97 | CAMKK1 | 0.26169175 |
| 98 | PRKD1 | 0.25940959 |
| 99 | PRKCZ | 0.24270844 |
| 100 | MTOR | 0.22650582 |
| 101 | CDK15 | 0.21349988 |
| 102 | ATM | 0.20765808 |
| 103 | PRKCQ | 0.20209391 |
| 104 | CDK18 | 0.18361924 |
| 105 | PRKAA1 | 0.17956318 |
| 106 | CDK11A | 0.16954353 |
| 107 | BRSK2 | 0.15698531 |
| 108 | PRKG2 | 0.15286880 |
| 109 | ATR | 0.14871071 |
| 110 | NEK6 | 0.13424278 |
| 111 | CSF1R | 0.12269060 |
| 112 | CDK14 | 0.12119059 |
| 113 | RPS6KB1 | 0.11363320 |
| 114 | BRSK1 | 0.11281856 |
| 115 | BRAF | 0.10762068 |
| 116 | RPS6KA1 | 0.10551639 |
| 117 | STK10 | 0.09021391 |
| 118 | PLK4 | 0.07978768 |
| 119 | GSK3B | 0.06508525 |
| 120 | PKN1 | 0.06314442 |
| 121 | PRKCD | 0.06256406 |
| 122 | CLK1 | 0.06150840 |
| 123 | PLK1 | 0.06114169 |
| 124 | CAMK2A | 0.06053882 |
| 125 | CSNK2A1 | 0.05923629 |
| 126 | STK11 | 0.05898034 |
| 127 | CDK6 | 0.04629765 |
| 128 | PRKG1 | 0.03375235 |
| 129 | PRKACG | 0.03221644 |
| 130 | MARK3 | 0.02851592 |
| 131 | EPHB1 | 0.02819608 |
| 132 | PIM1 | 0.02714275 |
| 133 | PRKCA | 0.02526125 |
| 134 | PRKCB | 0.02129604 |
| 135 | MAPK8 | 0.01907987 |
| 136 | PDGFRB | 0.00628331 |
| 137 | SRC | -0.0547167 |
| 138 | CDK12 | -0.0476970 |
| 139 | PRKACB | -0.0449387 |
| 140 | CDK4 | -0.0353018 |
| 141 | PRKACA | -0.0345337 |
| 142 | RPS6KA3 | -0.0279944 |
| 143 | PAK6 | -0.0236367 |
| 144 | YES1 | -0.0210505 |
| 145 | CSNK2A2 | -0.0153628 |
| 146 | TRIB3 | -0.0124517 |
| 147 | CSNK1D | -0.0103887 |
| 148 | MAP3K1 | -0.0089830 |
| 149 | CDK1 | -0.0045453 |
| 150 | EGFR | -0.0031865 |
| 151 | CDK2 | -0.0030815 |
| 152 | AURKA | -0.0018679 |
| 153 | WEE1 | -0.0002697 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 7.64543255 |
| 2 | Sulfur relay system_Homo sapiens_hsa04122 | 6.17305504 |
| 3 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 5.09557211 |
| 4 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 4.35643764 |
| 5 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 3.78556253 |
| 6 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 3.46776369 |
| 7 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 3.36149183 |
| 8 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 3.06107554 |
| 9 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 3.05387688 |
| 10 | Pyruvate metabolism_Homo sapiens_hsa00620 | 3.04098825 |
| 11 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 3.02738105 |
| 12 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 2.92487187 |
| 13 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 2.51112385 |
| 14 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 2.45562778 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.35713731 |
| 16 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.29327745 |
| 17 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 2.01126210 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 2.01048874 |
| 19 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.95602867 |
| 20 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.95365966 |
| 21 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.93431012 |
| 22 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.86394542 |
| 23 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.84343531 |
| 24 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.77682496 |
| 25 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.74159716 |
| 26 | Circadian rhythm_Homo sapiens_hsa04710 | 1.71840418 |
| 27 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.70167571 |
| 28 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.64445754 |
| 29 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.62894402 |
| 30 | Mineral absorption_Homo sapiens_hsa04978 | 1.60753650 |
| 31 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.59310181 |
| 32 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.59086857 |
| 33 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.58136407 |
| 34 | Lysine degradation_Homo sapiens_hsa00310 | 1.56080416 |
| 35 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.55604554 |
| 36 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.53436289 |
| 37 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.40385337 |
| 38 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.39812208 |
| 39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.34241056 |
| 40 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.32215749 |
| 41 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.31101624 |
| 42 | Carbon metabolism_Homo sapiens_hsa01200 | 1.30645805 |
| 43 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.29437434 |
| 44 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.21853562 |
| 45 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.21520370 |
| 46 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.18145495 |
| 47 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.17816670 |
| 48 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.17349936 |
| 49 | Nicotine addiction_Homo sapiens_hsa05033 | 1.15034882 |
| 50 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.10707643 |
| 51 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.10271300 |
| 52 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.07906248 |
| 53 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.07698695 |
| 54 | Homologous recombination_Homo sapiens_hsa03440 | 1.05948713 |
| 55 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.04783364 |
| 56 | Renin secretion_Homo sapiens_hsa04924 | 1.03132424 |
| 57 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.03075809 |
| 58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.99042151 |
| 59 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.96369477 |
| 60 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.95542484 |
| 61 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.94731766 |
| 62 | Insulin secretion_Homo sapiens_hsa04911 | 0.93041525 |
| 63 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.92609532 |
| 64 | Purine metabolism_Homo sapiens_hsa00230 | 0.90197758 |
| 65 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.88287577 |
| 66 | Bile secretion_Homo sapiens_hsa04976 | 0.82292882 |
| 67 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.82129152 |
| 68 | RNA polymerase_Homo sapiens_hsa03020 | 0.78925184 |
| 69 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.78570206 |
| 70 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.77799429 |
| 71 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.77148097 |
| 72 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.76917295 |
| 73 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.76002401 |
| 74 | Long-term potentiation_Homo sapiens_hsa04720 | 0.75270288 |
| 75 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.74528239 |
| 76 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.74007121 |
| 77 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.73711343 |
| 78 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.72636310 |
| 79 | Huntingtons disease_Homo sapiens_hsa05016 | 0.68509538 |
| 80 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.68127180 |
| 81 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.66807617 |
| 82 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.64688145 |
| 83 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.63771255 |
| 84 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.62889185 |
| 85 | Cell cycle_Homo sapiens_hsa04110 | 0.62075686 |
| 86 | Salivary secretion_Homo sapiens_hsa04970 | 0.61417934 |
| 87 | Olfactory transduction_Homo sapiens_hsa04740 | 0.57054696 |
| 88 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.56696891 |
| 89 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.56542513 |
| 90 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.56231212 |
| 91 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.54158392 |
| 92 | Legionellosis_Homo sapiens_hsa05134 | 0.54139548 |
| 93 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.52988274 |
| 94 | Bladder cancer_Homo sapiens_hsa05219 | 0.52500639 |
| 95 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.52081114 |
| 96 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.51637711 |
| 97 | Melanogenesis_Homo sapiens_hsa04916 | 0.50508780 |
| 98 | ABC transporters_Homo sapiens_hsa02010 | 0.50188051 |
| 99 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.49262300 |
| 100 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.48701148 |
| 101 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.48302669 |
| 102 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.46673105 |
| 103 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.46289169 |
| 104 | Retinol metabolism_Homo sapiens_hsa00830 | 0.44530300 |
| 105 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.43923167 |
| 106 | Base excision repair_Homo sapiens_hsa03410 | 0.43873159 |
| 107 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.43765675 |
| 108 | Endocytosis_Homo sapiens_hsa04144 | 0.43114274 |
| 109 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.42851854 |
| 110 | RNA transport_Homo sapiens_hsa03013 | 0.42836260 |
| 111 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.41458430 |
| 112 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41049016 |
| 113 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.40083119 |
| 114 | Insulin resistance_Homo sapiens_hsa04931 | 0.39427091 |
| 115 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.37678916 |
| 116 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.36873868 |
| 117 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.36856737 |
| 118 | Alcoholism_Homo sapiens_hsa05034 | 0.36513230 |
| 119 | Metabolic pathways_Homo sapiens_hsa01100 | 0.35823678 |
| 120 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.32896185 |
| 121 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.32721822 |
| 122 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.32436350 |
| 123 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.31708460 |
| 124 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.30557163 |
| 125 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.30443075 |
| 126 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.30434630 |
| 127 | Cocaine addiction_Homo sapiens_hsa05030 | 0.29565251 |
| 128 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.28472673 |
| 129 | Histidine metabolism_Homo sapiens_hsa00340 | 0.28117103 |
| 130 | Morphine addiction_Homo sapiens_hsa05032 | 0.27712323 |
| 131 | Circadian entrainment_Homo sapiens_hsa04713 | 0.25775857 |
| 132 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.25049774 |
| 133 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.24396219 |
| 134 | Taste transduction_Homo sapiens_hsa04742 | 0.23513086 |
| 135 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.23268869 |
| 136 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.23111154 |
| 137 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.21205698 |
| 138 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.20358784 |
| 139 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.19810415 |
| 140 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.18956112 |
| 141 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.18942063 |
| 142 | Gap junction_Homo sapiens_hsa04540 | 0.16637710 |
| 143 | Other glycan degradation_Homo sapiens_hsa00511 | 0.15348445 |
| 144 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.14499843 |
| 145 | Phototransduction_Homo sapiens_hsa04744 | 0.14236481 |
| 146 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.13924892 |
| 147 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.12429828 |
| 148 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.11747597 |
| 149 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.11282424 |
| 150 | Salmonella infection_Homo sapiens_hsa05132 | 0.09762694 |
| 151 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.09749436 |
| 152 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.08442569 |
| 153 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.08431524 |
| 154 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.08253199 |
| 155 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.06267521 |

