SLIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.55696668
2synaptic vesicle maturation (GO:0016188)6.50269448
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.31885590
4locomotory exploration behavior (GO:0035641)6.03739103
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.62877745
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.53392031
7glutamate secretion (GO:0014047)5.35475453
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32351174
9presynaptic membrane organization (GO:0097090)5.31563404
10vocalization behavior (GO:0071625)5.24184755
11nucleobase catabolic process (GO:0046113)5.23832807
12regulation of glutamate receptor signaling pathway (GO:1900449)5.09945762
13presynaptic membrane assembly (GO:0097105)5.05794126
14synaptic vesicle exocytosis (GO:0016079)5.02216523
15regulation of neuronal synaptic plasticity (GO:0048168)4.90103039
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.87347496
17exploration behavior (GO:0035640)4.85945003
18protein localization to synapse (GO:0035418)4.76907451
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.72971955
20regulation of synaptic vesicle exocytosis (GO:2000300)4.67461878
21dendritic spine morphogenesis (GO:0060997)4.66593408
22establishment of mitochondrion localization (GO:0051654)4.48695258
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.47687134
24regulation of synapse structural plasticity (GO:0051823)4.33568202
25neuron cell-cell adhesion (GO:0007158)4.33099974
26layer formation in cerebral cortex (GO:0021819)4.31438779
27regulation of synaptic vesicle transport (GO:1902803)4.24963154
28neuronal action potential propagation (GO:0019227)4.24862072
29axon ensheathment in central nervous system (GO:0032291)4.23954216
30central nervous system myelination (GO:0022010)4.23954216
31proline transport (GO:0015824)4.22101309
32positive regulation of synaptic transmission, GABAergic (GO:0032230)4.19554518
33synaptic transmission, glutamatergic (GO:0035249)4.17448125
34long-term memory (GO:0007616)4.14482216
35neurotransmitter secretion (GO:0007269)4.13710525
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.13248531
37glutamate receptor signaling pathway (GO:0007215)4.10073610
38innervation (GO:0060384)4.08444468
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.97168717
40mitochondrion transport along microtubule (GO:0047497)3.97168717
41sodium ion export (GO:0071436)3.93713210
42cellular potassium ion homeostasis (GO:0030007)3.90127561
43positive regulation of synapse maturation (GO:0090129)3.86712974
44axonal fasciculation (GO:0007413)3.82740621
45neuron recognition (GO:0008038)3.80895913
46neurotransmitter-gated ion channel clustering (GO:0072578)3.79427019
47cell communication by electrical coupling (GO:0010644)3.79249243
48regulation of synaptic plasticity (GO:0048167)3.69904237
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69635978
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64194149
51behavioral response to nicotine (GO:0035095)3.62142292
52response to auditory stimulus (GO:0010996)3.61859489
53positive regulation of membrane potential (GO:0045838)3.61061581
54forebrain neuron differentiation (GO:0021879)3.60097155
55neuron-neuron synaptic transmission (GO:0007270)3.60009569
56positive regulation of synapse assembly (GO:0051965)3.59629526
57gamma-aminobutyric acid transport (GO:0015812)3.59549920
58neuromuscular process controlling balance (GO:0050885)3.56526500
59dendrite morphogenesis (GO:0048813)3.55160919
60dendritic spine organization (GO:0097061)3.54909500
61synapse assembly (GO:0007416)3.54809114
62regulation of dendritic spine morphogenesis (GO:0061001)3.50893140
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.50584159
64mechanosensory behavior (GO:0007638)3.48324675
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46138693
66regulation of postsynaptic membrane potential (GO:0060078)3.45762025
67neuromuscular process controlling posture (GO:0050884)3.43573306
68synaptic vesicle endocytosis (GO:0048488)3.40995192
69neuromuscular synaptic transmission (GO:0007274)3.40118825
70activation of protein kinase A activity (GO:0034199)3.39826664
71neurofilament cytoskeleton organization (GO:0060052)3.34774428
72transmission of nerve impulse (GO:0019226)3.32916981
73cell migration in hindbrain (GO:0021535)3.30599124
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28063047
75positive regulation of dendritic spine development (GO:0060999)3.27915096
76neurotransmitter transport (GO:0006836)3.27859587
77central nervous system projection neuron axonogenesis (GO:0021952)3.26265703
78adult walking behavior (GO:0007628)3.25795180
79membrane depolarization during action potential (GO:0086010)3.24526569
80behavioral defense response (GO:0002209)3.24500826
81behavioral fear response (GO:0001662)3.24500826
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.24200701
83neuronal ion channel clustering (GO:0045161)3.23961346
84chemosensory behavior (GO:0007635)3.23402108
85regulation of vesicle fusion (GO:0031338)3.22627285
86adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.22137749
87cerebellar Purkinje cell differentiation (GO:0021702)3.19068714
88cerebellar granule cell differentiation (GO:0021707)3.16215452
89positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16106641
90cellular sodium ion homeostasis (GO:0006883)3.14569382
91regulation of ARF protein signal transduction (GO:0032012)3.11748416
92postsynaptic membrane organization (GO:0001941)3.11425232
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10602447
94regulation of neurotransmitter levels (GO:0001505)3.09181746
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08545820
96* negative regulation of axonogenesis (GO:0050771)3.07723817
97vesicle transport along microtubule (GO:0047496)3.07364150
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.07336638
99regulation of neurotransmitter secretion (GO:0046928)3.07300818
100* establishment of nucleus localization (GO:0040023)3.04307117
101membrane depolarization (GO:0051899)3.03841820
102synapse organization (GO:0050808)3.03134827
103long-term synaptic potentiation (GO:0060291)3.03041757
104learning (GO:0007612)3.02665547
105* retinal ganglion cell axon guidance (GO:0031290)3.02326637
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.99698649
107regulation of synaptic transmission (GO:0050804)2.99157043
108neuromuscular process (GO:0050905)2.96896432
109regulation of calcium ion-dependent exocytosis (GO:0017158)2.96848708
110regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95998169
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95987063
112negative regulation of oligodendrocyte differentiation (GO:0048715)2.95222667
113organelle transport along microtubule (GO:0072384)2.93924427
114cerebellar Purkinje cell layer development (GO:0021680)2.92678207
115negative regulation of microtubule polymerization (GO:0031115)2.91864286
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91518845
117startle response (GO:0001964)2.90971609
118axon cargo transport (GO:0008088)2.90900836
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90440895
120auditory behavior (GO:0031223)2.90309935
121fear response (GO:0042596)2.89736085
122* negative regulation of axon extension (GO:0030517)2.88815857
123regulation of dendritic spine development (GO:0060998)2.88551372
124cranial nerve morphogenesis (GO:0021602)2.87293549
125L-amino acid import (GO:0043092)2.87136581
126regulation of synapse maturation (GO:0090128)2.86939373
127glycine transport (GO:0015816)2.85914852
128central nervous system neuron axonogenesis (GO:0021955)2.85893193
129cochlea development (GO:0090102)2.85719901
130positive regulation of synaptic transmission (GO:0050806)2.83578719
131neuronal stem cell maintenance (GO:0097150)2.83188481
132synaptic transmission (GO:0007268)2.80715836
133* regulation of axonogenesis (GO:0050770)2.78942856
134* axon extension (GO:0048675)2.74740594
135cell differentiation in hindbrain (GO:0021533)2.74169107
136substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.70657720
137substrate-independent telencephalic tangential migration (GO:0021826)2.70657720
138prepulse inhibition (GO:0060134)2.69023503
139regulation of respiratory system process (GO:0044065)2.68710816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.61032241
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21562857
3GBX2_23144817_ChIP-Seq_PC3_Human3.18357888
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16635199
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06287472
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.92079146
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.92079146
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.83318975
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.78265226
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66068704
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.65583949
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65384883
13DROSHA_22980978_ChIP-Seq_HELA_Human2.61391793
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59386145
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57588213
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.56379848
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.46891805
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.46803177
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46042011
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43068447
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42703809
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39087122
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.38076130
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.36579443
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32179279
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27757858
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19771486
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09688479
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69318851
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.67779552
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60304771
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60169450
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.56377971
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55175180
35AR_21572438_ChIP-Seq_LNCaP_Human1.54822239
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53929364
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50283956
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45954774
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43909410
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43044953
41SMAD4_21799915_ChIP-Seq_A2780_Human1.42213893
42* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39880984
43ZNF274_21170338_ChIP-Seq_K562_Hela1.39174420
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38876136
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38496773
46KDM2B_26808549_Chip-Seq_K562_Human1.37762229
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37389063
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36213430
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35168941
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33736442
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32201886
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.29263962
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28863938
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26586677
55TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23287303
56* AR_19668381_ChIP-Seq_PC3_Human1.21902678
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.21513359
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.19465015
59AR_25329375_ChIP-Seq_VCAP_Human1.17573976
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15990560
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.13581424
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12919936
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12139904
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11079294
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10615930
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10313941
67* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07202788
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.07194158
69STAT3_23295773_ChIP-Seq_U87_Human1.07126831
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07050743
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.06688051
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05974537
73P300_19829295_ChIP-Seq_ESCs_Human1.05242677
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03567107
75* CTCF_27219007_Chip-Seq_Bcells_Human1.03276309
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.02335282
77* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01648256
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01500973
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01489277
80AHR_22903824_ChIP-Seq_MCF-7_Human1.01402761
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.00654653
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00411132
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99167025
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98642298
85ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97188695
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96887464
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96590721
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95536956
89RNF2_27304074_Chip-Seq_NSC_Mouse0.95257236
90* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94988663
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94897688
92* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94613360
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.94285386
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94135102
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.93907030
96TAF15_26573619_Chip-Seq_HEK293_Human0.93523420
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90742008
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.90428724
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90226835
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89635942
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89329391
102* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88487914
103* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88406017
104TCF4_23295773_ChIP-Seq_U87_Human0.87769851
105IGF1R_20145208_ChIP-Seq_DFB_Human0.87417618
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.86812047
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86690419
108BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86472178
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84992858
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.84370708
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82912606
112ISL1_27105846_Chip-Seq_CPCs_Mouse0.82419362
113TP53_16413492_ChIP-PET_HCT116_Human0.82195350
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80931752
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80683393
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80636443
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80636443
118RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79354890
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78602456
120RUNX2_22187159_ChIP-Seq_PCA_Human0.78417710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.56939174
2MP0003880_abnormal_central_pattern4.66008213
3MP0003635_abnormal_synaptic_transmissio4.15688869
4MP0004270_analgesia3.66621876
5MP0001968_abnormal_touch/_nociception3.43747001
6MP0002063_abnormal_learning/memory/cond3.32290642
7MP0009745_abnormal_behavioral_response3.23245011
8MP0002735_abnormal_chemical_nociception3.13601230
9MP0002064_seizures3.06562377
10MP0002736_abnormal_nociception_after2.82874142
11MP0005423_abnormal_somatic_nervous2.81496665
12MP0002734_abnormal_mechanical_nocicepti2.65276993
13MP0002572_abnormal_emotion/affect_behav2.56821561
14MP0004858_abnormal_nervous_system2.47287401
15MP0009046_muscle_twitch2.40972535
16MP0002272_abnormal_nervous_system2.33977873
17MP0001486_abnormal_startle_reflex2.26316618
18MP0000778_abnormal_nervous_system2.18377902
19MP0003136_yellow_coat_color2.17156764
20MP0002733_abnormal_thermal_nociception2.08890118
21MP0004811_abnormal_neuron_physiology2.01033581
22MP0001970_abnormal_pain_threshold1.97528072
23MP0009780_abnormal_chondrocyte_physiolo1.96667656
24MP0001501_abnormal_sleep_pattern1.92035514
25MP0000569_abnormal_digit_pigmentation1.90998882
26MP0002184_abnormal_innervation1.89554902
27MP0003329_amyloid_beta_deposits1.88563709
28MP0001440_abnormal_grooming_behavior1.86937548
29MP0002067_abnormal_sensory_capabilities1.86193385
30MP0002638_abnormal_pupillary_reflex1.80864490
31MP0006276_abnormal_autonomic_nervous1.80469940
32* MP0000955_abnormal_spinal_cord1.76555450
33MP0003283_abnormal_digestive_organ1.73668790
34MP0003787_abnormal_imprinting1.72279778
35MP0002909_abnormal_adrenal_gland1.70662719
36MP0008961_abnormal_basal_metabolism1.70072471
37MP0002557_abnormal_social/conspecific_i1.63194027
38MP0008569_lethality_at_weaning1.60323557
39MP0001188_hyperpigmentation1.59691342
40MP0002822_catalepsy1.59503850
41* MP0002882_abnormal_neuron_morphology1.50246289
42MP0005646_abnormal_pituitary_gland1.48821948
43MP0004885_abnormal_endolymph1.45229875
44MP0005386_behavior/neurological_phenoty1.42632185
45MP0004924_abnormal_behavior1.42632185
46MP0005645_abnormal_hypothalamus_physiol1.41214354
47MP0003122_maternal_imprinting1.39607793
48MP0002066_abnormal_motor_capabilities/c1.36075609
49MP0001529_abnormal_vocalization1.32757819
50MP0003879_abnormal_hair_cell1.28432738
51MP0003633_abnormal_nervous_system1.25844070
52MP0002152_abnormal_brain_morphology1.20529609
53MP0001485_abnormal_pinna_reflex1.15387193
54MP0002102_abnormal_ear_morphology1.12195577
55MP0001984_abnormal_olfaction1.10635787
56MP0003890_abnormal_embryonic-extraembry1.06450984
57MP0003631_nervous_system_phenotype1.06074666
58MP0001502_abnormal_circadian_rhythm1.04794754
59MP0003172_abnormal_lysosome_physiology1.01752581
60MP0000534_abnormal_ureter_morphology0.99646216
61MP0003075_altered_response_to0.98796204
62MP0002928_abnormal_bile_duct0.96298934
63MP0001177_atelectasis0.93953376
64MP0008872_abnormal_physiological_respon0.92762133
65MP0000751_myopathy0.92675011
66MP0004142_abnormal_muscle_tone0.92540523
67MP0001905_abnormal_dopamine_level0.91697441
68MP0002069_abnormal_eating/drinking_beha0.91677183
69MP0002234_abnormal_pharynx_morphology0.91459513
70MP0008877_abnormal_DNA_methylation0.91374920
71MP0000566_synostosis0.91150673
72MP0003634_abnormal_glial_cell0.90546542
73MP0003123_paternal_imprinting0.87956047
74MP0002249_abnormal_larynx_morphology0.87704892
75MP0002751_abnormal_autonomic_nervous0.84423203
76* MP0003861_abnormal_nervous_system0.82467515
77MP0002229_neurodegeneration0.82262885
78MP0005253_abnormal_eye_physiology0.82010483
79MP0000604_amyloidosis0.81695527
80MP0001986_abnormal_taste_sensitivity0.80674110
81MP0005195_abnormal_posterior_eye0.79653015
82MP0004133_heterotaxia0.78609994
83MP0002752_abnormal_somatic_nervous0.78525517
84MP0003942_abnormal_urinary_system0.78501235
85* MP0002081_perinatal_lethality0.76243133
86MP0002653_abnormal_ependyma_morphology0.75839757
87MP0003137_abnormal_impulse_conducting0.73931988
88MP0005394_taste/olfaction_phenotype0.73870030
89MP0005499_abnormal_olfactory_system0.73870030
90MP0003632_abnormal_nervous_system0.73391920
91MP0000631_abnormal_neuroendocrine_gland0.72027962
92MP0004742_abnormal_vestibular_system0.70547062
93MP0004085_abnormal_heartbeat0.70411064
94MP0001963_abnormal_hearing_physiology0.69846498
95MP0005409_darkened_coat_color0.67951289
96MP0005535_abnormal_body_temperature0.67454615
97MP0004510_myositis0.67166268
98MP0004130_abnormal_muscle_cell0.66820602
99MP0008789_abnormal_olfactory_epithelium0.66575579
100MP0003690_abnormal_glial_cell0.64085659
101MP0004233_abnormal_muscle_weight0.63131616
102MP0008874_decreased_physiological_sensi0.60395323
103MP0010386_abnormal_urinary_bladder0.60353512
104MP0001943_abnormal_respiration0.59359174
105MP0010769_abnormal_survival0.57843794
106MP0001299_abnormal_eye_distance/0.57741652
107MP0000026_abnormal_inner_ear0.57601590
108MP0003119_abnormal_digestive_system0.56431167
109MP0003121_genomic_imprinting0.56373261
110MP0001348_abnormal_lacrimal_gland0.55877438
111MP0001664_abnormal_digestion0.55460316
112MP0010770_preweaning_lethality0.55042359
113MP0002082_postnatal_lethality0.55042359
114MP0010768_mortality/aging0.53485135
115MP0010234_abnormal_vibrissa_follicle0.53201694
116MP0000920_abnormal_myelination0.53046827
117MP0005551_abnormal_eye_electrophysiolog0.52776752
118MP0005187_abnormal_penis_morphology0.52212332
119MP0003938_abnormal_ear_development0.52107017

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.19380229
2Focal motor seizures (HP:0011153)6.93495158
3Focal seizures (HP:0007359)5.58670610
4Visual hallucinations (HP:0002367)5.20216259
5Progressive cerebellar ataxia (HP:0002073)4.29652858
6Polyphagia (HP:0002591)4.11563742
7Epileptic encephalopathy (HP:0200134)4.07952724
8Supranuclear gaze palsy (HP:0000605)4.06451564
9Febrile seizures (HP:0002373)3.89710718
10Atonic seizures (HP:0010819)3.86721713
11Action tremor (HP:0002345)3.84449625
12Ankle clonus (HP:0011448)3.74070833
13Abnormality of the lower motor neuron (HP:0002366)3.71843994
14Absence seizures (HP:0002121)3.66795267
15Dialeptic seizures (HP:0011146)3.59439760
16Generalized tonic-clonic seizures (HP:0002069)3.52519965
17Mutism (HP:0002300)3.47447811
18Impaired vibration sensation in the lower limbs (HP:0002166)3.40995885
19Depression (HP:0000716)3.37343700
20Oligodactyly (hands) (HP:0001180)3.14229850
21Postural instability (HP:0002172)3.00233434
22Hyperventilation (HP:0002883)2.99132964
23Broad-based gait (HP:0002136)2.98437347
24Papilledema (HP:0001085)2.94529629
25Poor eye contact (HP:0000817)2.92714018
26Truncal ataxia (HP:0002078)2.90375174
27Urinary bladder sphincter dysfunction (HP:0002839)2.89386549
28Dysmetria (HP:0001310)2.88507271
29Amblyopia (HP:0000646)2.85888316
30Urinary urgency (HP:0000012)2.83048381
31Gait imbalance (HP:0002141)2.78127821
32Drooling (HP:0002307)2.76935775
33Excessive salivation (HP:0003781)2.76935775
34Abnormal eating behavior (HP:0100738)2.72580015
35Genetic anticipation (HP:0003743)2.70004556
36Spastic gait (HP:0002064)2.70004153
37Cortical dysplasia (HP:0002539)2.68255803
38Split foot (HP:0001839)2.68150605
39Insomnia (HP:0100785)2.68147202
40Ventricular fibrillation (HP:0001663)2.67636770
41Impaired social interactions (HP:0000735)2.66086288
42Abnormal social behavior (HP:0012433)2.66086288
43Anxiety (HP:0000739)2.62115950
44Dysdiadochokinesis (HP:0002075)2.55651071
45Anosmia (HP:0000458)2.48738923
46Scanning speech (HP:0002168)2.48071725
47Torticollis (HP:0000473)2.46679469
48Gaze-evoked nystagmus (HP:0000640)2.46555080
49Hemiplegia (HP:0002301)2.45020016
50Nephronophthisis (HP:0000090)2.42204504
51Cerebral inclusion bodies (HP:0100314)2.42019776
52Neurofibrillary tangles (HP:0002185)2.41736702
53Focal dystonia (HP:0004373)2.40960378
54Hemiparesis (HP:0001269)2.40289772
55Impaired smooth pursuit (HP:0007772)2.35767396
56Lissencephaly (HP:0001339)2.35215623
57Termporal pattern (HP:0011008)2.34787219
58Insidious onset (HP:0003587)2.34787219
59Pointed chin (HP:0000307)2.34624623
60Stereotypic behavior (HP:0000733)2.34400482
61Epileptiform EEG discharges (HP:0011182)2.33377557
62Amyotrophic lateral sclerosis (HP:0007354)2.32478823
63Lower limb muscle weakness (HP:0007340)2.28682159
64Progressive inability to walk (HP:0002505)2.27285125
65Pachygyria (HP:0001302)2.26421643
66Sleep apnea (HP:0010535)2.24355563
67Aqueductal stenosis (HP:0002410)2.23433352
68Megalencephaly (HP:0001355)2.23018074
69Septo-optic dysplasia (HP:0100842)2.22921695
70Bradykinesia (HP:0002067)2.22406646
71Annular pancreas (HP:0001734)2.22104432
72EEG with generalized epileptiform discharges (HP:0011198)2.20090286
73Agitation (HP:0000713)2.19489583
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19046993
75Intention tremor (HP:0002080)2.18977609
76Abnormality of the corticospinal tract (HP:0002492)2.18693943
77Apathy (HP:0000741)2.17527167
78Retinal dysplasia (HP:0007973)2.16824184
79Hypsarrhythmia (HP:0002521)2.13239709
80Abnormality of ocular smooth pursuit (HP:0000617)2.13234759
81Morphological abnormality of the pyramidal tract (HP:0002062)2.11794407
82Abnormality of the diencephalon (HP:0010662)2.11095667
83Hypoplasia of the corpus callosum (HP:0002079)2.10663884
84Oligodactyly (HP:0012165)2.09817142
85Spastic tetraplegia (HP:0002510)2.09558776
86Impaired vibratory sensation (HP:0002495)2.09343497
87Anophthalmia (HP:0000528)2.08211709
88Absent speech (HP:0001344)2.05253417
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.03778316
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.03778316
91Medial flaring of the eyebrow (HP:0010747)2.02190072
92Intestinal atresia (HP:0011100)2.02171905
93Pheochromocytoma (HP:0002666)2.00120681
94Congenital primary aphakia (HP:0007707)1.98208886
95Diplopia (HP:0000651)1.95683174
96Abnormality of binocular vision (HP:0011514)1.95683174
97Genital tract atresia (HP:0001827)1.95282114
98Abnormality of the 4th metacarpal (HP:0010012)1.94783411
99Craniofacial dystonia (HP:0012179)1.94549436
100Vaginal atresia (HP:0000148)1.93521060
101Generalized myoclonic seizures (HP:0002123)1.93194769
102Incomplete penetrance (HP:0003829)1.93129723
103Inappropriate behavior (HP:0000719)1.92545070
104Fetal akinesia sequence (HP:0001989)1.92466149
105Hypoventilation (HP:0002791)1.92441672
106Rapidly progressive (HP:0003678)1.92130130
107Diminished motivation (HP:0000745)1.91419756
108Nephrogenic diabetes insipidus (HP:0009806)1.91042012
109Status epilepticus (HP:0002133)1.90126852
110Hypoplasia of the brainstem (HP:0002365)1.89706670
111Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89706670
112True hermaphroditism (HP:0010459)1.88830349
113Hepatoblastoma (HP:0002884)1.88757412
114Ankyloglossia (HP:0010296)1.88443485
115Abnormality of the labia minora (HP:0012880)1.87833833
116Neoplasm of the heart (HP:0100544)1.87310026
117Obstructive sleep apnea (HP:0002870)1.87304847
118Failure to thrive in infancy (HP:0001531)1.86779179
119Pancreatic fibrosis (HP:0100732)1.86532871
120Abnormality of the renal medulla (HP:0100957)1.86510477
121Clonus (HP:0002169)1.86465878
122Optic nerve hypoplasia (HP:0000609)1.85286334
123Exotropia (HP:0000577)1.85270967
124Chronic hepatic failure (HP:0100626)1.85244370
125Abnormality of salivation (HP:0100755)1.84701389
126Peripheral hypomyelination (HP:0007182)1.84254327
127Type II lissencephaly (HP:0007260)1.84097792
128Abnormal ciliary motility (HP:0012262)1.83070661
129Akinesia (HP:0002304)1.82825101
130Bronchomalacia (HP:0002780)1.81692123
131Limb dystonia (HP:0002451)1.81580238
132Abnormal EKG (HP:0003115)1.81441307
133Abnormal respiratory motile cilium morphology (HP:0005938)1.81403286
134Abnormal respiratory epithelium morphology (HP:0012253)1.81403286
135Protruding tongue (HP:0010808)1.80441021
136Cutaneous finger syndactyly (HP:0010554)1.78413893
137Bundle branch block (HP:0011710)1.77902564
138Gait ataxia (HP:0002066)1.77857252
139Hammertoe (HP:0001765)1.76583241
140Ulnar claw (HP:0001178)1.76578072
141Specific learning disability (HP:0001328)1.75882908
142Hyperacusis (HP:0010780)1.75643527
143Molar tooth sign on MRI (HP:0002419)1.75382647
144Abnormality of midbrain morphology (HP:0002418)1.75382647
145Rib fusion (HP:0000902)1.74496389
146Short 4th metacarpal (HP:0010044)1.68921826
147Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68921826
148Abnormal respiratory motile cilium physiology (HP:0012261)1.68849106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.01223608
2MAP3K94.22775175
3EPHA43.74925099
4MARK13.51546496
5MINK12.94270751
6MAPK152.81849872
7NTRK22.78323811
8KSR12.56080682
9KSR22.45977927
10MAP3K42.45827483
11PAK62.36292867
12DYRK22.31360900
13PRKD32.26192200
14DAPK22.00274886
15MAP2K71.93491414
16TYRO31.91869588
17EPHA31.87743061
18NTRK11.82589092
19MAP3K121.63492405
20CAMKK11.61855753
21MAP2K41.61838408
22CDK51.54483968
23TNIK1.40338997
24UHMK11.40105460
25PINK11.38762871
26PRPF4B1.34431366
27LATS21.32173233
28MAP3K131.31176356
29MAPK131.28029315
30STK381.27583788
31DAPK11.27055080
32LMTK21.22856241
33SIK21.22259656
34ARAF1.21572219
35PRKCG1.20099555
36PLK21.18184444
37PHKG21.16864529
38PHKG11.16864529
39MAP3K21.15840944
40RET1.15557827
41FGFR21.13618490
42BRSK11.11644394
43EPHB11.11251708
44CDK181.04738300
45GRK51.04472650
46CDC42BPA1.02305266
47WNK30.99861682
48CDK150.98833504
49CAMK10.97402682
50SIK30.97366116
51FES0.97316270
52RIPK40.97265991
53PAK30.94547264
54CDK140.93276107
55WNK40.93012385
56ALK0.88545403
57DYRK1B0.87526572
58CDK11A0.87046610
59PDGFRA0.87041955
60PKN10.83460292
61TAOK20.82885652
62TAOK10.82132166
63MAP3K70.80454838
64CAMK2A0.79791530
65DDR20.78356460
66CAMK1D0.74891956
67CDK190.74718185
68PRKCH0.73158968
69CAMK2B0.73145502
70MARK20.73104097
71STK110.73044078
72RAF10.72534486
73BCR0.70952259
74DYRK30.70661879
75PNCK0.70568461
76PTK2B0.69512458
77SGK2230.67442376
78SGK4940.67442376
79CSNK1G20.67052740
80MAP3K10.65645763
81CSNK1G30.65231367
82FER0.63829288
83PRKCZ0.60619545
84PDK10.60229138
85DYRK1A0.59519750
86NEK10.58811084
87CSNK1A1L0.58265770
88SGK10.56829567
89CDK30.55668622
90NEK60.55292797
91EPHB20.53699997
92PDPK10.52854302
93ICK0.52013507
94CASK0.50655275
95RPS6KA30.47867169
96NME10.47286597
97FYN0.46534202
98DMPK0.45682380
99CSNK1G10.44572221
100CAMK1G0.43694636
101MAPK100.43624505
102STK390.42885607
103SCYL20.42200865
104FGR0.41728694
105WNK10.40700883
106BMPR1B0.40348456
107CSNK1E0.40012531
108TSSK60.39363815
109SGK20.39187089
110CSNK1D0.39181227
111PRKCE0.38742566
112CAMK40.38484346
113SGK30.38383810
114ERBB20.37893868
115PRKG10.37094735
116TRIM280.36872514
117MAP2K60.36443865
118MAP3K50.36353701
119MAP2K10.35759026
120PRKACA0.35418384
121PRKAA10.34025515
122ERBB30.33186676
123RPS6KA20.33075194
124ADRBK10.31339023
125MAPK80.29604500
126MAP4K20.29418702
127GSK3B0.28371477
128CAMKK20.28310681
129MATK0.28099206
130PRKDC0.27932260
131CAMK2G0.27654518
132LIMK10.26748232
133CSNK1A10.26505214
134OXSR10.24836930

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.52976373
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12207086
3Circadian entrainment_Homo sapiens_hsa047132.74203188
4Olfactory transduction_Homo sapiens_hsa047402.72918540
5Long-term potentiation_Homo sapiens_hsa047202.63390654
6GABAergic synapse_Homo sapiens_hsa047272.54037610
7Glutamatergic synapse_Homo sapiens_hsa047242.51087018
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47664727
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46910159
10Amphetamine addiction_Homo sapiens_hsa050312.32194379
11Morphine addiction_Homo sapiens_hsa050322.24050704
12Salivary secretion_Homo sapiens_hsa049702.09140541
13Insulin secretion_Homo sapiens_hsa049112.07367424
14Dopaminergic synapse_Homo sapiens_hsa047282.06712983
15Aldosterone synthesis and secretion_Homo sapiens_hsa049252.01943092
16Cholinergic synapse_Homo sapiens_hsa047251.84998564
17Gastric acid secretion_Homo sapiens_hsa049711.84323880
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71275650
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65267812
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61905245
21Calcium signaling pathway_Homo sapiens_hsa040201.59216365
22Oxytocin signaling pathway_Homo sapiens_hsa049211.58525026
23Taste transduction_Homo sapiens_hsa047421.57328238
24GnRH signaling pathway_Homo sapiens_hsa049121.56690667
25Long-term depression_Homo sapiens_hsa047301.47058386
26Glioma_Homo sapiens_hsa052141.44572698
27* Axon guidance_Homo sapiens_hsa043601.40989390
28Serotonergic synapse_Homo sapiens_hsa047261.40383759
29Cocaine addiction_Homo sapiens_hsa050301.39591290
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38383807
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37681396
32Renin secretion_Homo sapiens_hsa049241.33446818
33Type II diabetes mellitus_Homo sapiens_hsa049301.31910180
34Dorso-ventral axis formation_Homo sapiens_hsa043201.29038237
35Gap junction_Homo sapiens_hsa045401.27935333
36cAMP signaling pathway_Homo sapiens_hsa040241.23524306
37Estrogen signaling pathway_Homo sapiens_hsa049151.22801684
38ErbB signaling pathway_Homo sapiens_hsa040121.21059802
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20963184
40Melanogenesis_Homo sapiens_hsa049161.17846097
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14985033
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14083495
43Basal cell carcinoma_Homo sapiens_hsa052171.12730058
44Oocyte meiosis_Homo sapiens_hsa041141.06729793
45Nitrogen metabolism_Homo sapiens_hsa009101.06278658
46Collecting duct acid secretion_Homo sapiens_hsa049660.99231758
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96753078
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.95934886
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92696373
50Choline metabolism in cancer_Homo sapiens_hsa052310.92249499
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89473863
52VEGF signaling pathway_Homo sapiens_hsa043700.89089312
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.87507141
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86373737
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85084335
56Vibrio cholerae infection_Homo sapiens_hsa051100.83615137
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.81099413
58Thyroid hormone synthesis_Homo sapiens_hsa049180.78746712
59Pancreatic secretion_Homo sapiens_hsa049720.77943925
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75177581
61Butanoate metabolism_Homo sapiens_hsa006500.75047526
62Prion diseases_Homo sapiens_hsa050200.74554815
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72842758
64mTOR signaling pathway_Homo sapiens_hsa041500.72823193
65MAPK signaling pathway_Homo sapiens_hsa040100.70719722
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70204105
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69922682
68Dilated cardiomyopathy_Homo sapiens_hsa054140.68613933
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67765604
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66675143
71Cardiac muscle contraction_Homo sapiens_hsa042600.66265541
72Non-small cell lung cancer_Homo sapiens_hsa052230.65307390
73Glucagon signaling pathway_Homo sapiens_hsa049220.63419826
74Alzheimers disease_Homo sapiens_hsa050100.63396753
75Parkinsons disease_Homo sapiens_hsa050120.62847104
76Rap1 signaling pathway_Homo sapiens_hsa040150.60919689
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60494933
78Endocytosis_Homo sapiens_hsa041440.59982391
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59938398
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58940129
81Ras signaling pathway_Homo sapiens_hsa040140.58628412
82Wnt signaling pathway_Homo sapiens_hsa043100.58390482
83Endometrial cancer_Homo sapiens_hsa052130.58193446
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58002768
85Oxidative phosphorylation_Homo sapiens_hsa001900.56859322
86Bile secretion_Homo sapiens_hsa049760.56102686
87Steroid biosynthesis_Homo sapiens_hsa001000.54010818
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.53537747
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50665683
90Insulin signaling pathway_Homo sapiens_hsa049100.49340706
91Notch signaling pathway_Homo sapiens_hsa043300.48729782
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48390293
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48275096
94Inositol phosphate metabolism_Homo sapiens_hsa005620.47998919
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47970313
96Alcoholism_Homo sapiens_hsa050340.47919579
97Tight junction_Homo sapiens_hsa045300.45791910
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43039491
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.41728050
100Type I diabetes mellitus_Homo sapiens_hsa049400.38916102
101Huntingtons disease_Homo sapiens_hsa050160.38492625
102Renal cell carcinoma_Homo sapiens_hsa052110.38077252
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37942238
104Hedgehog signaling pathway_Homo sapiens_hsa043400.37589577
105Prolactin signaling pathway_Homo sapiens_hsa049170.37082615
106Colorectal cancer_Homo sapiens_hsa052100.36965946
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.36950736
108Phototransduction_Homo sapiens_hsa047440.35478280
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33367805
110Regulation of autophagy_Homo sapiens_hsa041400.33265650
111Ovarian steroidogenesis_Homo sapiens_hsa049130.29341797
112Chemokine signaling pathway_Homo sapiens_hsa040620.29161514
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27688761
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27488111
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27011626
116Hippo signaling pathway_Homo sapiens_hsa043900.25175924
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24829951

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