SLIT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.23443597
2* neuron projection extension involved in neuron projection guidance (GO:1902284)7.17032486
3* axon extension involved in axon guidance (GO:0048846)7.17032486
4tachykinin receptor signaling pathway (GO:0007217)7.16211483
5positive regulation of uterine smooth muscle contraction (GO:0070474)6.21924954
6somite development (GO:0061053)5.92587238
7glomerular filtration (GO:0003094)5.69508713
8lung epithelium development (GO:0060428)5.52751007
9glomerular basement membrane development (GO:0032836)5.18191108
10dopaminergic neuron differentiation (GO:0071542)5.14781235
11renal filtration (GO:0097205)5.08643087
12regulation of uterine smooth muscle contraction (GO:0070472)4.90691578
13chondrocyte development (GO:0002063)4.88232892
14negative regulation of axon extension involved in axon guidance (GO:0048843)4.80025132
15cell proliferation involved in metanephros development (GO:0072203)4.69716042
16axonal fasciculation (GO:0007413)4.45194182
17hyperosmotic salinity response (GO:0042538)4.44362305
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.43762564
19establishment of nucleus localization (GO:0040023)4.42007781
20* negative regulation of axon guidance (GO:1902668)4.35996407
21regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.32754003
22positive regulation of gastrulation (GO:2000543)4.22996697
23* negative chemotaxis (GO:0050919)4.22102168
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.19707670
25mesenchymal-epithelial cell signaling (GO:0060638)4.14319732
26innervation (GO:0060384)4.13164468
27thalamus development (GO:0021794)3.99167354
28negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.98402115
29* retinal ganglion cell axon guidance (GO:0031290)3.96551713
30dendritic spine morphogenesis (GO:0060997)3.91967186
31intraciliary transport (GO:0042073)3.87551374
32positive regulation of synaptic transmission, GABAergic (GO:0032230)3.87326956
33neuronal stem cell maintenance (GO:0097150)3.85087268
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84302385
35establishment of apical/basal cell polarity (GO:0035089)3.83759466
36regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.79467182
37establishment of tissue polarity (GO:0007164)3.79200181
38establishment of planar polarity (GO:0001736)3.79200181
39negative regulation of embryonic development (GO:0045992)3.77115050
40epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.74371349
41dorsal/ventral neural tube patterning (GO:0021904)3.72959684
42glomerular epithelial cell development (GO:0072310)3.72125566
43branch elongation of an epithelium (GO:0060602)3.70876981
44positive regulation of tolerance induction (GO:0002645)3.70806236
45negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.65547192
46regulation of mesenchymal cell apoptotic process (GO:2001053)3.65134005
47establishment of monopolar cell polarity (GO:0061162)3.64667898
48establishment or maintenance of monopolar cell polarity (GO:0061339)3.64667898
49epithelial cilium movement (GO:0003351)3.63323373
50* motor neuron axon guidance (GO:0008045)3.59061238
51lung lobe morphogenesis (GO:0060463)3.53385488
52regulation of axon extension involved in axon guidance (GO:0048841)3.52012300
53artery development (GO:0060840)3.50943549
54limb bud formation (GO:0060174)3.50838122
55mesenchymal cell proliferation (GO:0010463)3.50082834
56collagen fibril organization (GO:0030199)3.49985783
57heparan sulfate proteoglycan metabolic process (GO:0030201)3.46860573
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.45808468
59midbrain development (GO:0030901)3.43503768
60positive regulation of BMP signaling pathway (GO:0030513)3.41341575
61prostate gland growth (GO:0060736)3.40411956
62regulation of non-canonical Wnt signaling pathway (GO:2000050)3.40368059
63positive regulation of neuroblast proliferation (GO:0002052)3.37722028
64axis elongation (GO:0003401)3.36768086
65branching involved in salivary gland morphogenesis (GO:0060445)3.36712935
66cilium movement (GO:0003341)3.36643598
67smoothened signaling pathway (GO:0007224)3.35375258
68regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34750895
69mesenchyme morphogenesis (GO:0072132)3.34372661
70cell proliferation involved in kidney development (GO:0072111)3.34312478
71hindlimb morphogenesis (GO:0035137)3.33145441
72* regulation of axon guidance (GO:1902667)3.32495149
73G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.32169451
74endocardial cushion morphogenesis (GO:0003203)3.26193937
75neuron recognition (GO:0008038)3.25576800
76positive regulation of embryonic development (GO:0040019)3.25562456
77regulation of organ formation (GO:0003156)3.24495271
78embryonic hindlimb morphogenesis (GO:0035116)3.24484252
79lung-associated mesenchyme development (GO:0060484)3.24471463
80primitive streak formation (GO:0090009)3.24454274
81embryonic forelimb morphogenesis (GO:0035115)3.22790064
82nonmotile primary cilium assembly (GO:0035058)3.22636671
83negative regulation of T cell differentiation in thymus (GO:0033085)3.21723446
84negative regulation of B cell mediated immunity (GO:0002713)3.21487519
85negative regulation of immunoglobulin mediated immune response (GO:0002890)3.21487519
86sequestering of actin monomers (GO:0042989)3.15934739
87left/right pattern formation (GO:0060972)3.14378362
88positive regulation of heart rate (GO:0010460)3.11636308
89forelimb morphogenesis (GO:0035136)3.11462056
90regulation of mesoderm development (GO:2000380)3.10930993
91neuronal action potential propagation (GO:0019227)3.10903498
92striated muscle cell proliferation (GO:0014855)3.09565307
93lateral sprouting from an epithelium (GO:0060601)3.06804445
94hindbrain development (GO:0030902)3.06191645
95bone trabecula formation (GO:0060346)3.05996625
96presynaptic membrane assembly (GO:0097105)3.05674051
97negative regulation of humoral immune response (GO:0002921)3.05033148
98regulation of tolerance induction (GO:0002643)3.04227080
99embryonic foregut morphogenesis (GO:0048617)3.02643477
100extracellular fibril organization (GO:0043206)3.02515198
101regulation of feeding behavior (GO:0060259)3.01363926
102dorsal/ventral pattern formation (GO:0009953)3.00430633
103Notch signaling involved in heart development (GO:0061314)2.99879944
104neuroblast proliferation (GO:0007405)2.99133702
105pyrimidine nucleobase catabolic process (GO:0006208)2.99081732
106insulin-like growth factor receptor signaling pathway (GO:0048009)2.98818123
107camera-type eye morphogenesis (GO:0048593)2.97559056
108astrocyte differentiation (GO:0048708)2.94419802
109embryonic skeletal system development (GO:0048706)2.94276257
110paraxial mesoderm development (GO:0048339)2.93923971
111embryonic digestive tract morphogenesis (GO:0048557)2.93480827
112negative regulation of smooth muscle cell differentiation (GO:0051151)2.88790611
113otic vesicle formation (GO:0030916)2.86863504
114cell proliferation in forebrain (GO:0021846)2.86186440
115positive regulation of smoothened signaling pathway (GO:0045880)2.84631811
116positive regulation of oligodendrocyte differentiation (GO:0048714)2.83787611
117postsynaptic membrane organization (GO:0001941)2.83587116
118reproductive system development (GO:0061458)2.83225788
119cell migration involved in heart development (GO:0060973)2.82302752
120cilium morphogenesis (GO:0060271)2.82119492
121negative regulation of oligodendrocyte differentiation (GO:0048715)2.81507806
122* regulation of chemokine-mediated signaling pathway (GO:0070099)2.80354379
123male genitalia development (GO:0030539)2.80031788
124organ formation (GO:0048645)2.79318938
125convergent extension (GO:0060026)2.79188501
126neuron fate determination (GO:0048664)2.79065196
127regulation of cardioblast proliferation (GO:0003264)2.78484825
128regulation of secondary heart field cardioblast proliferation (GO:0003266)2.78484825
129radial glial cell differentiation (GO:0060019)2.77609346
130regulation of catecholamine metabolic process (GO:0042069)2.77306447
131regulation of dopamine metabolic process (GO:0042053)2.77306447
132presynaptic membrane organization (GO:0097090)2.76441134
133positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76134879
134lens fiber cell development (GO:0070307)2.75358401
135DNA integration (GO:0015074)2.75043544
136renal system development (GO:0072001)2.74457950
137cilium assembly (GO:0042384)2.74194482
138calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74052118
139hippo signaling (GO:0035329)2.73065682
140cilium organization (GO:0044782)2.72027000
141determination of left/right symmetry (GO:0007368)2.71512985
142nucleus localization (GO:0051647)2.70061145
143appendage development (GO:0048736)2.70034983
144limb development (GO:0060173)2.70034983
145regulation of heart morphogenesis (GO:2000826)2.68367767
146* negative regulation of axon extension (GO:0030517)2.68139604
147determination of bilateral symmetry (GO:0009855)2.67846266
148regulation of smoothened signaling pathway (GO:0008589)2.67194515
149tongue development (GO:0043586)2.63970340
150spinal cord development (GO:0021510)2.63878976
151specification of symmetry (GO:0009799)2.63851062
152axonemal dynein complex assembly (GO:0070286)2.62396214
153olfactory bulb development (GO:0021772)2.62042099
154regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.60647713
155neural crest cell development (GO:0014032)2.60351864
156positive regulation of mesenchymal cell proliferation (GO:0002053)2.59670505
157protein polyglutamylation (GO:0018095)2.59412242
158negative regulation of chondrocyte differentiation (GO:0032331)2.56378088
159stem cell development (GO:0048864)2.55863495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.12908191
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.94466442
3* EED_16625203_ChIP-ChIP_MESCs_Mouse3.69909107
4GBX2_23144817_ChIP-Seq_PC3_Human3.57068675
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.38598209
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.03192771
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.03192771
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.97468394
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.86528312
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.85617799
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.83544780
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83415955
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81774440
14* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.73289067
15* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.65531960
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56537763
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.51144756
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47991248
19* RNF2_27304074_Chip-Seq_ESCs_Mouse2.46173688
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31117276
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22352734
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.21090360
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.17771681
24* EWS_26573619_Chip-Seq_HEK293_Human2.17706437
25* FUS_26573619_Chip-Seq_HEK293_Human2.14648791
26* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11449985
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10180597
28* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08397606
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.04650968
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01806844
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.95215627
32* TP53_20018659_ChIP-ChIP_R1E_Mouse1.95092155
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94195001
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93717559
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82351857
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81318856
37IGF1R_20145208_ChIP-Seq_DFB_Human1.78212722
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75506347
39DROSHA_22980978_ChIP-Seq_HELA_Human1.70178867
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67334039
41TP53_16413492_ChIP-PET_HCT116_Human1.65004810
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59719142
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.58312994
44* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56752183
45* RING1B_27294783_Chip-Seq_ESCs_Mouse1.50417734
46* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50005324
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.49817139
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48908871
49* P300_19829295_ChIP-Seq_ESCs_Human1.47926730
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47406260
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.46514367
52* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45831354
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39995441
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39552230
55* RING1B_27294783_Chip-Seq_NPCs_Mouse1.39086459
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38583678
57* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.35844029
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35031011
59* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33897870
60ZNF274_21170338_ChIP-Seq_K562_Hela1.33521191
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31564272
62* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30442152
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29624149
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29559975
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29434134
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29434134
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.29001530
68* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28237803
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27385074
70* TAF15_26573619_Chip-Seq_HEK293_Human1.24919192
71TP53_18474530_ChIP-ChIP_U2OS_Human1.24844900
72SMAD4_21799915_ChIP-Seq_A2780_Human1.24097324
73VDR_22108803_ChIP-Seq_LS180_Human1.23989522
74* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23923506
75* STAT3_23295773_ChIP-Seq_U87_Human1.22555848
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22229556
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.21734282
78* AR_25329375_ChIP-Seq_VCAP_Human1.21189789
79BCAT_22108803_ChIP-Seq_LS180_Human1.20863024
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20451642
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19533274
82CJUN_26792858_Chip-Seq_BT549_Human1.19157762
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18683849
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18319495
85* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17027491
86AHR_22903824_ChIP-Seq_MCF-7_Human1.16896540
87* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16188131
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14204567
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12571749
90* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12495601
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11492684
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.09952142
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.08941996
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08792612
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08781982
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08304309
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06305362
98RNF2_27304074_Chip-Seq_NSC_Mouse1.05127784
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05035317
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04948168
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04877508
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.04810273
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04652963
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04269428
105IRF1_19129219_ChIP-ChIP_H3396_Human1.03074675
106TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02594547
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02373809
108* AR_19668381_ChIP-Seq_PC3_Human1.01380371
109AR_21572438_ChIP-Seq_LNCaP_Human1.00277628
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00102099
111* EP300_21415370_ChIP-Seq_HL-1_Mouse0.99838021
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99820539
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99707414
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99534456
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99320356
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99156399
117SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98942018
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.98676009
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.98434146
120HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97534554
121* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97288552
122* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97156926
123SOX9_26525672_Chip-Seq_HEART_Mouse0.96420929
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95643640
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95643640
126REST_21632747_ChIP-Seq_MESCs_Mouse0.94950283
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.94610813
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94445066
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93916778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.58915991
2MP0008438_abnormal_cutaneous_collagen3.60889176
3MP0005503_abnormal_tendon_morphology3.15979585
4MP0000566_synostosis2.69763912
5MP0009053_abnormal_anal_canal2.69444534
6MP0010030_abnormal_orbit_morphology2.56501399
7MP0000537_abnormal_urethra_morphology2.55217133
8MP0006292_abnormal_olfactory_placode2.53663094
9MP0004133_heterotaxia2.45577131
10MP0002234_abnormal_pharynx_morphology2.40596078
11MP0002102_abnormal_ear_morphology2.40234474
12MP0002282_abnormal_trachea_morphology2.38670833
13MP0003122_maternal_imprinting2.33450271
14MP0005623_abnormal_meninges_morphology2.10613789
15* MP0003942_abnormal_urinary_system2.05776932
16MP0003136_yellow_coat_color2.03437644
17MP0000383_abnormal_hair_follicle1.94671084
18MP0009384_cardiac_valve_regurgitation1.94356408
19MP0003115_abnormal_respiratory_system1.91584208
20MP0000467_abnormal_esophagus_morphology1.90881334
21MP0003279_aneurysm1.82865232
22MP0002735_abnormal_chemical_nociception1.79951653
23MP0005275_abnormal_skin_tensile1.78200683
24MP0000778_abnormal_nervous_system1.76149008
25MP0002932_abnormal_joint_morphology1.72432519
26MP0005508_abnormal_skeleton_morphology1.71999444
27MP0003880_abnormal_central_pattern1.70507906
28MP0002751_abnormal_autonomic_nervous1.66015023
29MP0005171_absent_coat_pigmentation1.64977905
30MP0000569_abnormal_digit_pigmentation1.64338194
31MP0004859_abnormal_synaptic_plasticity1.62667543
32MP0001293_anophthalmia1.62271015
33MP0004272_abnormal_basement_membrane1.60880418
34MP0001286_abnormal_eye_development1.59376364
35* MP0000534_abnormal_ureter_morphology1.58265728
36MP0002249_abnormal_larynx_morphology1.57737428
37MP0005076_abnormal_cell_differentiation1.57700182
38MP0003937_abnormal_limbs/digits/tail_de1.56666511
39MP0000049_abnormal_middle_ear1.55772837
40MP0001299_abnormal_eye_distance/1.54801065
41MP0008961_abnormal_basal_metabolism1.52506693
42MP0009250_abnormal_appendicular_skeleto1.52352984
43MP0003385_abnormal_body_wall1.50903115
44MP0000428_abnormal_craniofacial_morphol1.49228227
45MP0008789_abnormal_olfactory_epithelium1.45794564
46MP0002108_abnormal_muscle_morphology1.44292080
47MP0002653_abnormal_ependyma_morphology1.43999930
48MP0001346_abnormal_lacrimal_gland1.43386341
49MP0000955_abnormal_spinal_cord1.40375665
50MP0002184_abnormal_innervation1.40123547
51MP0000462_abnormal_digestive_system1.35802893
52MP0002736_abnormal_nociception_after1.34890977
53MP0003938_abnormal_ear_development1.33699244
54MP0001984_abnormal_olfaction1.30326921
55MP0001958_emphysema1.29241608
56MP0002233_abnormal_nose_morphology1.26451630
57MP0003755_abnormal_palate_morphology1.22987810
58MP0002116_abnormal_craniofacial_bone1.22249328
59MP0001968_abnormal_touch/_nociception1.20016089
60MP0002938_white_spotting1.18613374
61MP0006072_abnormal_retinal_apoptosis1.18353328
62MP0003315_abnormal_perineum_morphology1.17056683
63MP0010678_abnormal_skin_adnexa1.15531846
64MP0005391_vision/eye_phenotype1.14834499
65MP0005499_abnormal_olfactory_system1.14716028
66MP0005394_taste/olfaction_phenotype1.14716028
67MP0002896_abnormal_bone_mineralization1.14295698
68MP0003121_genomic_imprinting1.13537806
69MP0005187_abnormal_penis_morphology1.13488169
70MP0003890_abnormal_embryonic-extraembry1.13238029
71MP0003091_abnormal_cell_migration1.11941399
72MP0003861_abnormal_nervous_system1.10882152
73MP0002697_abnormal_eye_size1.10267419
74MP0000579_abnormal_nail_morphology1.09859003
75MP0003635_abnormal_synaptic_transmissio1.09494833
76MP0002277_abnormal_respiratory_mucosa1.09395877
77MP0000631_abnormal_neuroendocrine_gland1.09203053
78MP0004134_abnormal_chest_morphology1.04874582
79MP0002089_abnormal_postnatal_growth/wei1.03934359
80MP0003119_abnormal_digestive_system1.02210488
81MP0002092_abnormal_eye_morphology1.01526506
82MP0001529_abnormal_vocalization1.01500730
83MP0000372_irregular_coat_pigmentation1.01405152
84MP0006054_spinal_hemorrhage1.00909678
85MP0000733_abnormal_muscle_development1.00787211
86MP0010368_abnormal_lymphatic_system0.99704433
87MP0003935_abnormal_craniofacial_develop0.99502493
88MP0000432_abnormal_head_morphology0.99215104
89MP0000163_abnormal_cartilage_morphology0.97341504
90MP0004233_abnormal_muscle_weight0.96687929
91MP0005257_abnormal_intraocular_pressure0.96553809
92MP0005253_abnormal_eye_physiology0.94886765
93MP0000026_abnormal_inner_ear0.94714255
94MP0005423_abnormal_somatic_nervous0.93199428
95MP0006276_abnormal_autonomic_nervous0.91986842
96MP0002109_abnormal_limb_morphology0.90391509
97MP0005248_abnormal_Harderian_gland0.89840061
98MP0001324_abnormal_eye_pigmentation0.89672392
99MP0004084_abnormal_cardiac_muscle0.89304335
100MP0005551_abnormal_eye_electrophysiolog0.89101458
101MP0001177_atelectasis0.88945519
102MP0002168_other_aberrant_phenotype0.87811921
103MP0004145_abnormal_muscle_electrophysio0.86001518
104MP0002882_abnormal_neuron_morphology0.85737088
105MP0003705_abnormal_hypodermis_morpholog0.85084262
106MP0004142_abnormal_muscle_tone0.84644213
107MP0002928_abnormal_bile_duct0.84546858
108MP0003137_abnormal_impulse_conducting0.82428286
109MP0002111_abnormal_tail_morphology0.81881231
110MP0003941_abnormal_skin_development0.81381080
111MP0002177_abnormal_outer_ear0.80517652
112MP0005195_abnormal_posterior_eye0.80243356
113MP0002063_abnormal_learning/memory/cond0.79690512
114MP0005220_abnormal_exocrine_pancreas0.79551950
115MP0002114_abnormal_axial_skeleton0.79440022
116MP0002752_abnormal_somatic_nervous0.79351185
117MP0005197_abnormal_uvea_morphology0.79186524
118* MP0002081_perinatal_lethality0.78615533
119MP0000647_abnormal_sebaceous_gland0.78502926
120MP0002084_abnormal_developmental_patter0.77408940
121MP0002113_abnormal_skeleton_development0.77305533
122MP0002115_abnormal_skeleton_extremities0.77161881
123MP0001943_abnormal_respiration0.77159911
124MP0000762_abnormal_tongue_morphology0.76190732
125MP0002152_abnormal_brain_morphology0.75786176
126MP0004742_abnormal_vestibular_system0.75385080
127MP0002557_abnormal_social/conspecific_i0.72179781
128MP0000613_abnormal_salivary_gland0.70095763
129* MP0002085_abnormal_embryonic_tissue0.68681563
130MP0003011_delayed_dark_adaptation0.68279506
131MP0000427_abnormal_hair_cycle0.68163163

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.98026078
2Premature rupture of membranes (HP:0001788)4.39302642
3True hermaphroditism (HP:0010459)3.83817546
4Septo-optic dysplasia (HP:0100842)3.71575516
5Shallow orbits (HP:0000586)3.48679033
6Pancreatic fibrosis (HP:0100732)3.47936694
7Aortic aneurysm (HP:0004942)3.34740487
8Aortic dissection (HP:0002647)3.16005552
9Ankle contracture (HP:0006466)3.09579679
10Abnormality of midbrain morphology (HP:0002418)3.09115193
11Molar tooth sign on MRI (HP:0002419)3.09115193
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.07107023
13Short 4th metacarpal (HP:0010044)3.07107023
14Narrow nasal bridge (HP:0000446)3.06792394
15Growth hormone deficiency (HP:0000824)3.00588960
16Pancreatic cysts (HP:0001737)2.99639853
17Postaxial foot polydactyly (HP:0001830)2.92954407
18Bilateral microphthalmos (HP:0007633)2.80491622
19Aplasia/Hypoplasia of the tongue (HP:0010295)2.76525108
20Preaxial hand polydactyly (HP:0001177)2.74704746
21Medial flaring of the eyebrow (HP:0010747)2.73534592
22Bifid tongue (HP:0010297)2.73056891
23Dilatation of the ascending aorta (HP:0005111)2.71673183
24Abnormality of the phalanges of the 2nd finger (HP:0009541)2.69696256
25Maternal diabetes (HP:0009800)2.68633986
26Postaxial hand polydactyly (HP:0001162)2.68568187
27Morphological abnormality of the middle ear (HP:0008609)2.67471579
28Gait imbalance (HP:0002141)2.67163158
29Nephronophthisis (HP:0000090)2.66438637
30Congenital primary aphakia (HP:0007707)2.63110561
31Anophthalmia (HP:0000528)2.62024066
32Abnormality of dentin (HP:0010299)2.59770009
33Abnormal ciliary motility (HP:0012262)2.56983461
34Wrist flexion contracture (HP:0001239)2.56804059
35Vascular tortuosity (HP:0004948)2.56799639
36Soft skin (HP:0000977)2.56747617
37Vaginal atresia (HP:0000148)2.52173294
38Genital tract atresia (HP:0001827)2.50553040
39Bladder diverticulum (HP:0000015)2.48361276
40Abdominal situs inversus (HP:0003363)2.47624893
41Abnormality of abdominal situs (HP:0011620)2.47624893
42Peritonitis (HP:0002586)2.46391186
43Broad metatarsal (HP:0001783)2.45802719
44Central scotoma (HP:0000603)2.42514362
45Anencephaly (HP:0002323)2.39165065
46Abnormality of the 4th metacarpal (HP:0010012)2.38974300
47Abnormality of the right ventricle (HP:0001707)2.36668118
48Cystic liver disease (HP:0006706)2.36041645
49Abnormal number of incisors (HP:0011064)2.36021027
50Coronal craniosynostosis (HP:0004440)2.35271724
51Abnormal respiratory motile cilium morphology (HP:0005938)2.34561024
52Abnormal respiratory epithelium morphology (HP:0012253)2.34561024
53Blue sclerae (HP:0000592)2.34411542
54Bowel diverticulosis (HP:0005222)2.32506749
55Nephrogenic diabetes insipidus (HP:0009806)2.31432448
56High anterior hairline (HP:0009890)2.28637335
57Mitral valve prolapse (HP:0001634)2.27843204
58Abnormal respiratory motile cilium physiology (HP:0012261)2.27526255
59Deviation of the hallux (HP:0010051)2.26885590
60Occipital encephalocele (HP:0002085)2.25010198
61Arterial tortuosity (HP:0005116)2.24174717
62Hallux valgus (HP:0001822)2.23578958
63Bifid scrotum (HP:0000048)2.22297404
64Neonatal short-limb short stature (HP:0008921)2.21475469
65Sclerocornea (HP:0000647)2.19940045
66Mesomelia (HP:0003027)2.19643533
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.18309181
68Absent/shortened dynein arms (HP:0200106)2.18309181
69Synostosis of carpal bones (HP:0005048)2.16350095
70Genu recurvatum (HP:0002816)2.14265409
71Hypoplastic pelvis (HP:0008839)2.14024012
72Cerebral aneurysm (HP:0004944)2.13964487
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.13446212
74Decreased central vision (HP:0007663)2.13085349
75Wide anterior fontanel (HP:0000260)2.12108136
76Abnormality of the phalanges of the hallux (HP:0010057)2.11897621
77Infantile muscular hypotonia (HP:0008947)2.11614843
78Absent septum pellucidum (HP:0001331)2.10987638
79Cone-rod dystrophy (HP:0000548)2.09682915
80Chronic hepatic failure (HP:0100626)2.08800985
81Abnormality of the renal medulla (HP:0100957)2.08663253
82Short tibia (HP:0005736)2.07018320
83Oligodactyly (HP:0012165)2.06036041
84Hepatoblastoma (HP:0002884)2.05464292
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05076623
86Diaphragmatic weakness (HP:0009113)2.04242668
87Atrophic scars (HP:0001075)2.01986150
88Tarsal synostosis (HP:0008368)2.00583707
89Aplasia/Hypoplasia of the fibula (HP:0006492)1.99960003
90Poor coordination (HP:0002370)1.99589140
91Broad foot (HP:0001769)1.99361090
92Abnormality of the fibula (HP:0002991)1.99125005
93Labial hypoplasia (HP:0000066)1.98806544
94Lymphangioma (HP:0100764)1.98270923
95Partial duplication of the phalanx of hand (HP:0009999)1.97900315
96Fragile skin (HP:0001030)1.97840608
97Hypoventilation (HP:0002791)1.95402799
98Renal duplication (HP:0000075)1.95022157
99Broad toe (HP:0001837)1.94158297
100Synostosis involving bones of the feet (HP:0009140)1.93905582
101Synostosis involving bones of the lower limbs (HP:0009138)1.93905582
102Septate vagina (HP:0001153)1.92922209
103Short nail (HP:0001799)1.91960634
104Wormian bones (HP:0002645)1.91046376
105Oligodactyly (hands) (HP:0001180)1.90929602
106Ulnar deviation of finger (HP:0009465)1.89774222
107Fibular hypoplasia (HP:0003038)1.89703108
108Tented upper lip vermilion (HP:0010804)1.89350325
109Aplasia/Hypoplasia of the lens (HP:0008063)1.89037816
110Midline defect of the nose (HP:0004122)1.88761486
111Specific learning disability (HP:0001328)1.88730752
112Supernumerary spleens (HP:0009799)1.88356463
113Broad finger (HP:0001500)1.87986285
114Trigonocephaly (HP:0000243)1.87869076
115Scotoma (HP:0000575)1.86694119
116Esophageal atresia (HP:0002032)1.86678404
117Abnormality of the upper arm (HP:0001454)1.86083996
118Abnormality of the labia minora (HP:0012880)1.85740850
119Broad thumb (HP:0011304)1.85611963
120Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.84260397
121Broad phalanx (HP:0006009)1.84212713
122Preaxial foot polydactyly (HP:0001841)1.84120641
123Focal seizures (HP:0007359)1.83306439
124Tubular atrophy (HP:0000092)1.82723121
125Abnormality of the 2nd finger (HP:0004100)1.82263151
126Aplasia cutis congenita (HP:0001057)1.82074635
127Broad ribs (HP:0000885)1.81815581
128Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81193774
129Increased corneal curvature (HP:0100692)1.81024124
130Keratoconus (HP:0000563)1.81024124
131Triphalangeal thumb (HP:0001199)1.79438425
132Bicornuate uterus (HP:0000813)1.78975424
133Concave nail (HP:0001598)1.78784763
134Fibular aplasia (HP:0002990)1.78600649
135Broad long bones (HP:0005622)1.78519159
136Rhinitis (HP:0012384)1.77934583
137Ankyloglossia (HP:0010296)1.77057219
138Holoprosencephaly (HP:0001360)1.76980553
139Renal dysplasia (HP:0000110)1.76757970
140Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.76749222
141Abnormality of the middle phalanges of the toes (HP:0010183)1.76595275
142Joint laxity (HP:0001388)1.75114598
143Abnormality of the septum pellucidum (HP:0007375)1.74717722
144Cervical subluxation (HP:0003308)1.74234342
145Broad phalanges of the hand (HP:0009768)1.74103852
146Congenital hepatic fibrosis (HP:0002612)1.73565246
147Atelectasis (HP:0100750)1.72532490
148Cutaneous finger syndactyly (HP:0010554)1.72319093
149Carpal synostosis (HP:0009702)1.72081350
150Anal stenosis (HP:0002025)1.71779122
151Absent frontal sinuses (HP:0002688)1.71754483
152Aplasia involving bones of the extremities (HP:0009825)1.71682809
153Aplasia involving bones of the upper limbs (HP:0009823)1.71682809
154Aplasia of the phalanges of the hand (HP:0009802)1.71682809
155Hypoplastic female external genitalia (HP:0012815)1.71679511
156Short foot (HP:0001773)1.71216587
157Biconcave vertebral bodies (HP:0004586)1.70268161
158Syringomyelia (HP:0003396)1.69668855
159Spinal cord lesions (HP:0100561)1.69668855
160Exotropia (HP:0000577)1.69042576
161Abnormality of the astrocytes (HP:0100707)1.67925729
162Astrocytoma (HP:0009592)1.67925729
163Abnormality of the radial head (HP:0003995)1.67754185
164Type 1 muscle fiber predominance (HP:0003803)1.66826704
165Hypoplastic labia majora (HP:0000059)1.65952362
166Abnormality of the parathyroid morphology (HP:0011766)1.65429244
167Long toe (HP:0010511)1.64835832
168Abnormality of the incisor (HP:0000676)1.64576899
169Abnormality of macular pigmentation (HP:0008002)1.64478614
170Neoplasm of the heart (HP:0100544)1.63320557
171Increased number of teeth (HP:0011069)1.62425388

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.92967261
2KSR15.58641366
3EPHB25.13199262
4BCR3.59649858
5NTRK13.42925684
6TNIK3.22298477
7PNCK3.17729593
8MARK13.03897994
9SIK12.94349126
10NTRK22.94323896
11DDR22.82397663
12MAPK152.58136539
13MKNK12.43770359
14MAP3K42.23752032
15PDGFRA2.19889726
16WNK32.16587479
17MINK12.10201736
18TRIM281.90495495
19BMPR1B1.89826275
20WEE11.86885266
21FGFR21.82322578
22DYRK31.79734365
23ERBB21.69573178
24MKNK21.66913023
25NEK91.65058581
26MAP4K21.60619255
27EPHA31.58976546
28SRPK11.57974922
29EIF2AK31.55044968
30STK38L1.51951879
31PAK31.40498498
32TGFBR11.33140482
33CDC42BPA1.26841588
34NEK11.26666460
35ICK1.23944203
36TYRO31.23112034
37LATS21.22411729
38FGFR11.21109225
39NUAK11.20211857
40MELK1.18289412
41CDK181.17389035
42MAP2K71.15457575
43TTN1.15198621
44BRSK11.13095731
45NTRK31.12212235
46PLK21.11757497
47MAP3K101.11085370
48FER1.10586309
49UHMK11.07892634
50CSNK1G11.07375998
51CSNK1G21.06938659
52BRSK21.05405325
53ROCK21.03875569
54BCKDK1.02736323
55CSNK1G31.02118687
56LATS10.99512600
57PINK10.98775994
58RPS6KA40.98585256
59FRK0.97591623
60AKT30.93697145
61PLK40.92524015
62DMPK0.92265201
63CDK140.90556361
64VRK10.89154687
65PAK60.88810581
66ACVR1B0.86968122
67CDK150.85081538
68RIPK10.82495150
69TAOK20.80441979
70BRD40.76552943
71ROCK10.76324376
72CDK11A0.75265023
73NEK60.74305220
74ERBB30.72620213
75CDK30.71044917
76PAK20.70875383
77PTK2B0.69880300
78CAMK1G0.68701281
79CHUK0.64707108
80PTK20.62138217
81GRK10.61798482
82CDC70.61305381
83MTOR0.61274099
84STK30.60574990
85STK380.60481931
86ADRBK20.59664041
87CDK190.59396670
88TGFBR20.59175364
89PRKCE0.58747872
90ADRBK10.57256375
91EPHA40.56958506
92CAMK40.54775670
93SRC0.54018919
94EIF2AK20.53674474
95MAP2K40.53222606
96PDGFRB0.52813748
97ZAK0.52493038
98PRKCZ0.52309921
99PLK30.51697468
100INSRR0.50383133
101CAMK1D0.49917596
102PAK40.49446619
103PRKCG0.49122221
104TIE10.49056465
105NEK20.48232008
106SIK20.47853638
107TSSK60.47777971
108CDK50.47624199
109PASK0.46884791
110CDK80.46742952
111MYLK0.44286324
112LIMK10.42881204
113CAMK10.42289983
114STK390.42052587
115MAPK90.41511053
116FYN0.41342130
117CAMKK20.40681710
118BUB10.38099009
119TRIB30.37909267
120MATK0.37716503
121MAPK100.37424464
122DYRK20.37326432
123MAP3K70.36675923
124CASK0.36371458
125AURKB0.35727084
126IRAK10.35213703
127IRAK20.32669398
128FGFR40.32555318
129WNK10.32391470
130DYRK1B0.29842491
131CHEK20.28850825
132DYRK1A0.28399491
133CDK120.27680815
134CAMK2A0.27187911
135PHKG10.26387060
136PHKG20.26387060
137MET0.26132399
138MAP3K50.24585971
139PLK10.24436855
140CDK10.24396717
141PKN10.24050278
142RET0.23424118
143INSR0.23187219
144ATR0.22546299
145CSNK1A1L0.22426623
146MAPK130.22314944
147PRKAA10.21651267
148CSNK1E0.20864259
149LMTK20.20334408
150AURKA0.20172893

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.32259882
2Nicotine addiction_Homo sapiens_hsa050333.28031645
3Protein export_Homo sapiens_hsa030602.86511334
4Hedgehog signaling pathway_Homo sapiens_hsa043402.81176475
5Notch signaling pathway_Homo sapiens_hsa043302.61431291
6Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.50893131
7* Axon guidance_Homo sapiens_hsa043602.44484921
8Hippo signaling pathway_Homo sapiens_hsa043902.16246126
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94830337
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94264686
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92014481
12Propanoate metabolism_Homo sapiens_hsa006401.87998638
13Steroid biosynthesis_Homo sapiens_hsa001001.81122497
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80187265
15Synaptic vesicle cycle_Homo sapiens_hsa047211.77295006
16ECM-receptor interaction_Homo sapiens_hsa045121.76988559
17Dilated cardiomyopathy_Homo sapiens_hsa054141.73169914
18Circadian entrainment_Homo sapiens_hsa047131.70938766
19MicroRNAs in cancer_Homo sapiens_hsa052061.70371360
20Wnt signaling pathway_Homo sapiens_hsa043101.66304441
21Melanogenesis_Homo sapiens_hsa049161.65073473
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64959544
23Fanconi anemia pathway_Homo sapiens_hsa034601.58721538
24GABAergic synapse_Homo sapiens_hsa047271.54275476
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46405136
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45594584
27Glioma_Homo sapiens_hsa052141.44379741
28Morphine addiction_Homo sapiens_hsa050321.44098634
29Cholinergic synapse_Homo sapiens_hsa047251.42058875
30Bladder cancer_Homo sapiens_hsa052191.41666978
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40513179
32Focal adhesion_Homo sapiens_hsa045101.39511945
33Proteoglycans in cancer_Homo sapiens_hsa052051.38613576
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35816502
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34708393
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34240547
37TGF-beta signaling pathway_Homo sapiens_hsa043501.33721898
38Nitrogen metabolism_Homo sapiens_hsa009101.33170066
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30749098
40Huntingtons disease_Homo sapiens_hsa050161.29778460
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29016613
42Chronic myeloid leukemia_Homo sapiens_hsa052201.26470008
43Oxidative phosphorylation_Homo sapiens_hsa001901.24955352
44Parkinsons disease_Homo sapiens_hsa050121.24511989
45Glutamatergic synapse_Homo sapiens_hsa047241.24009611
46Basal transcription factors_Homo sapiens_hsa030221.23479011
47Dorso-ventral axis formation_Homo sapiens_hsa043201.22507855
48ErbB signaling pathway_Homo sapiens_hsa040121.18448955
49Estrogen signaling pathway_Homo sapiens_hsa049151.18419634
50Adherens junction_Homo sapiens_hsa045201.16919424
51Gap junction_Homo sapiens_hsa045401.15387222
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14450135
53Oxytocin signaling pathway_Homo sapiens_hsa049211.11229903
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11217209
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09756458
56Melanoma_Homo sapiens_hsa052181.09066068
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.08870059
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07766902
59Cardiac muscle contraction_Homo sapiens_hsa042601.05862561
60Oocyte meiosis_Homo sapiens_hsa041141.04736254
61Butanoate metabolism_Homo sapiens_hsa006501.04567655
62Insulin secretion_Homo sapiens_hsa049111.02956787
63Dopaminergic synapse_Homo sapiens_hsa047281.02352080
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01312537
65Calcium signaling pathway_Homo sapiens_hsa040201.00781586
66Cell cycle_Homo sapiens_hsa041100.97422572
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96743311
68Salivary secretion_Homo sapiens_hsa049700.94376170
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93824648
70Long-term potentiation_Homo sapiens_hsa047200.93706707
71Colorectal cancer_Homo sapiens_hsa052100.93067796
72Pathways in cancer_Homo sapiens_hsa052000.92814651
73Cocaine addiction_Homo sapiens_hsa050300.92613276
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90628475
75Tight junction_Homo sapiens_hsa045300.90581362
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90415103
77RNA polymerase_Homo sapiens_hsa030200.89633491
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.89402044
79Renin secretion_Homo sapiens_hsa049240.88698974
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88640162
81Serotonergic synapse_Homo sapiens_hsa047260.87849555
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87507208
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.87305336
84Renal cell carcinoma_Homo sapiens_hsa052110.86651756
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85968860
86Olfactory transduction_Homo sapiens_hsa047400.85159593
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84126394
88mTOR signaling pathway_Homo sapiens_hsa041500.83158873
89Long-term depression_Homo sapiens_hsa047300.80281447
90Taste transduction_Homo sapiens_hsa047420.78811243
91Phototransduction_Homo sapiens_hsa047440.78750979
92GnRH signaling pathway_Homo sapiens_hsa049120.77500840
93Rap1 signaling pathway_Homo sapiens_hsa040150.76458287
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75200839
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.74959789
96N-Glycan biosynthesis_Homo sapiens_hsa005100.74736546
97Homologous recombination_Homo sapiens_hsa034400.74162104
98Endometrial cancer_Homo sapiens_hsa052130.73765207
99Protein digestion and absorption_Homo sapiens_hsa049740.73755029
100Alzheimers disease_Homo sapiens_hsa050100.73360366
101Nucleotide excision repair_Homo sapiens_hsa034200.73070674
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72915416
103Amphetamine addiction_Homo sapiens_hsa050310.72862611
104HTLV-I infection_Homo sapiens_hsa051660.72708646
105Pancreatic cancer_Homo sapiens_hsa052120.72271971
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72269185
107Tryptophan metabolism_Homo sapiens_hsa003800.72244536
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.71669814
109Small cell lung cancer_Homo sapiens_hsa052220.71518977
110Spliceosome_Homo sapiens_hsa030400.71189664
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.70359914
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70332755
113Non-homologous end-joining_Homo sapiens_hsa034500.67979474
114Type II diabetes mellitus_Homo sapiens_hsa049300.67297430
115RNA transport_Homo sapiens_hsa030130.67262053
116RNA degradation_Homo sapiens_hsa030180.66589453
117Non-small cell lung cancer_Homo sapiens_hsa052230.65512002
118Amoebiasis_Homo sapiens_hsa051460.64550790
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.63789202
120Vibrio cholerae infection_Homo sapiens_hsa051100.63625778
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61401818
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.60884073
123Ribosome_Homo sapiens_hsa030100.60652321
124Selenocompound metabolism_Homo sapiens_hsa004500.59836787
125Choline metabolism in cancer_Homo sapiens_hsa052310.59189546
126Circadian rhythm_Homo sapiens_hsa047100.58863178
127Peroxisome_Homo sapiens_hsa041460.58041521
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56600726
129Fatty acid elongation_Homo sapiens_hsa000620.56077826
130Mismatch repair_Homo sapiens_hsa034300.56006544
131Pyruvate metabolism_Homo sapiens_hsa006200.55969380
132Alcoholism_Homo sapiens_hsa050340.55711033
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55632651
134Lysine degradation_Homo sapiens_hsa003100.55585361
135Gastric acid secretion_Homo sapiens_hsa049710.54431400
136MAPK signaling pathway_Homo sapiens_hsa040100.54320243
137Viral myocarditis_Homo sapiens_hsa054160.53210011
138cAMP signaling pathway_Homo sapiens_hsa040240.52960815
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52496809
140Ras signaling pathway_Homo sapiens_hsa040140.51089359
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50625214
142beta-Alanine metabolism_Homo sapiens_hsa004100.50176311
143mRNA surveillance pathway_Homo sapiens_hsa030150.49967785
144Linoleic acid metabolism_Homo sapiens_hsa005910.49735862
145Regulation of autophagy_Homo sapiens_hsa041400.47667066
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45900234
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44847006
148Folate biosynthesis_Homo sapiens_hsa007900.44654372
149Base excision repair_Homo sapiens_hsa034100.41019790
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40161645

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