SLIT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.21982580
2collagen fibril organization (GO:0030199)6.05278838
3bone trabecula formation (GO:0060346)6.00852800
4sequestering of extracellular ligand from receptor (GO:0035581)5.65435975
5chondrocyte proliferation (GO:0035988)4.98236378
6mesenchymal-epithelial cell signaling (GO:0060638)4.86416644
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.56121098
8endodermal cell differentiation (GO:0035987)4.27389045
9collagen metabolic process (GO:0032963)4.24910254
10* neuron projection extension involved in neuron projection guidance (GO:1902284)4.22813573
11* axon extension involved in axon guidance (GO:0048846)4.22813573
12extracellular fibril organization (GO:0043206)4.19168326
13collagen catabolic process (GO:0030574)4.18965332
14multicellular organismal macromolecule metabolic process (GO:0044259)4.06740320
15virion attachment to host cell (GO:0019062)3.98963129
16adhesion of symbiont to host cell (GO:0044650)3.98963129
17type B pancreatic cell proliferation (GO:0044342)3.89546841
18skin morphogenesis (GO:0043589)3.89277117
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.88929258
20multicellular organismal catabolic process (GO:0044243)3.85099116
21multicellular organismal metabolic process (GO:0044236)3.84192831
22peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.83681038
23craniofacial suture morphogenesis (GO:0097094)3.80291279
24extracellular matrix assembly (GO:0085029)3.78690897
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.72141921
26basement membrane organization (GO:0071711)3.66756136
27negative regulation of fatty acid transport (GO:2000192)3.62122756
28fibril organization (GO:0097435)3.61372517
29plasma membrane repair (GO:0001778)3.51527531
30cell proliferation involved in metanephros development (GO:0072203)3.45873326
31positive regulation of fibroblast migration (GO:0010763)3.44734914
32extracellular matrix disassembly (GO:0022617)3.43883091
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.43364392
34outer ear morphogenesis (GO:0042473)3.42811186
35negative regulation of chondrocyte differentiation (GO:0032331)3.42319540
36apoptotic cell clearance (GO:0043277)3.39597996
37adhesion of symbiont to host (GO:0044406)3.34723337
38cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.33680615
39metanephric mesenchyme development (GO:0072075)3.33495534
40smooth muscle tissue development (GO:0048745)3.31529348
41positive regulation of endothelial cell apoptotic process (GO:2000353)3.30570683
42glomerular basement membrane development (GO:0032836)3.29077458
43cell migration involved in heart development (GO:0060973)3.28819224
44insulin-like growth factor receptor signaling pathway (GO:0048009)3.26171286
45dermatan sulfate biosynthetic process (GO:0030208)3.24458822
46cellular response to vitamin (GO:0071295)3.22948822
47negative regulation of smooth muscle cell migration (GO:0014912)3.20286376
48blood vessel maturation (GO:0001955)3.14263821
49glomerular filtration (GO:0003094)3.12551004
50endocardial cushion development (GO:0003197)3.11545282
51negative regulation of catenin import into nucleus (GO:0035414)3.08983770
52extracellular negative regulation of signal transduction (GO:1900116)3.07942605
53extracellular regulation of signal transduction (GO:1900115)3.07942605
54negative regulation of cartilage development (GO:0061037)3.05191269
55kidney mesenchyme development (GO:0072074)3.04829577
56chondrocyte development (GO:0002063)3.03841426
57hippo signaling (GO:0035329)3.02473194
58glial cell migration (GO:0008347)3.01405112
59G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.98608585
60branching involved in salivary gland morphogenesis (GO:0060445)2.98177776
61regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.92719661
62dermatan sulfate metabolic process (GO:0030205)2.92364697
63positive regulation of gastrulation (GO:2000543)2.91887766
64regulation of axon extension involved in axon guidance (GO:0048841)2.90269156
65cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.88882309
66tooth mineralization (GO:0034505)2.88807207
67stress fiber assembly (GO:0043149)2.87277744
68negative regulation of BMP signaling pathway (GO:0030514)2.86445348
69renal filtration (GO:0097205)2.85579012
70regulation of axon guidance (GO:1902667)2.85101701
71embryonic cranial skeleton morphogenesis (GO:0048701)2.84159823
72negative regulation of embryonic development (GO:0045992)2.83799622
73trabecula formation (GO:0060343)2.83707782
74Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.83450782
75vascular endothelial growth factor signaling pathway (GO:0038084)2.82846104
76paraxial mesoderm development (GO:0048339)2.82138449
77middle ear morphogenesis (GO:0042474)2.81690561
78positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.80525908
79pericardium development (GO:0060039)2.78948764
80venous blood vessel morphogenesis (GO:0048845)2.78702507
81protein localization to cell surface (GO:0034394)2.78630190
82positive regulation of epithelial to mesenchymal transition (GO:0010718)2.78525134
83cell adhesion mediated by integrin (GO:0033627)2.78095155
84regulation of establishment of planar polarity (GO:0090175)2.77818424
85negative regulation of leukocyte chemotaxis (GO:0002689)2.75202222
86wound healing, spreading of epidermal cells (GO:0035313)2.75195430
87retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74499152
88polarized epithelial cell differentiation (GO:0030859)2.73679955
89negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.72643622
90cell proliferation involved in kidney development (GO:0072111)2.72156911
91cell migration involved in sprouting angiogenesis (GO:0002042)2.71830352
92peptidyl-proline hydroxylation (GO:0019511)2.67829894
93cardiac myofibril assembly (GO:0055003)2.67823108
94establishment of nucleus localization (GO:0040023)2.67564739
95extracellular matrix organization (GO:0030198)2.66885552
96non-canonical Wnt signaling pathway (GO:0035567)2.66106192
97fibroblast migration (GO:0010761)2.65954820
98extracellular structure organization (GO:0043062)2.65893834
99positive regulation of mesenchymal cell proliferation (GO:0002053)2.64346039
100regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.63976299
101cellular response to vitamin D (GO:0071305)2.63714737
102artery development (GO:0060840)2.61477811
103negative regulation of axon extension involved in axon guidance (GO:0048843)2.59839573
104regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.59462614
105barbed-end actin filament capping (GO:0051016)2.58316730
106lung-associated mesenchyme development (GO:0060484)2.57988135
107negative regulation of axon guidance (GO:1902668)2.57386157
108regulation of tight junction assembly (GO:2000810)2.57179978
109cellular response to amino acid stimulus (GO:0071230)2.56500573
110regulation of integrin-mediated signaling pathway (GO:2001044)2.56110775
111regulation of phospholipase A2 activity (GO:0032429)2.53400740
112regulation of cartilage development (GO:0061035)2.53268272
113endothelial cell morphogenesis (GO:0001886)2.52920700
114cranial suture morphogenesis (GO:0060363)2.52884522
115mesenchymal cell proliferation (GO:0010463)2.51789148
116axis elongation (GO:0003401)2.51417341
117artery morphogenesis (GO:0048844)2.50478058
118negative regulation of adherens junction organization (GO:1903392)2.49546814
119negative regulation of focal adhesion assembly (GO:0051895)2.49546814
120negative regulation of cell junction assembly (GO:1901889)2.49546814
121keratan sulfate catabolic process (GO:0042340)2.49198984
122substrate adhesion-dependent cell spreading (GO:0034446)2.48308013
123substrate-dependent cell migration (GO:0006929)2.47882809
124outflow tract septum morphogenesis (GO:0003148)2.44726581
125endocrine hormone secretion (GO:0060986)2.44479264
126positive regulation of metanephros development (GO:0072216)2.44185918
127metanephric tubule development (GO:0072170)2.43959831
128metanephric nephron tubule development (GO:0072234)2.43959831
129regulation of mesenchymal cell proliferation (GO:0010464)2.40673968
130regulation of cardioblast proliferation (GO:0003264)2.34876857
131regulation of secondary heart field cardioblast proliferation (GO:0003266)2.34876857
132negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.33832566
133negative regulation of osteoblast proliferation (GO:0033689)2.33798780
134cell-substrate junction assembly (GO:0007044)2.33369581
135positive regulation of smoothened signaling pathway (GO:0045880)2.30956380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.88995918
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.07491304
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.96272102
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.74132668
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.70220721
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61475860
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61475860
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.60918046
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44999283
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32340274
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29928281
12* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23882957
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23856635
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19998125
15* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.19093429
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.08966133
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.06086219
18* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05384134
19CLOCK_20551151_ChIP-Seq_293T_Human2.01145132
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98964078
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93704016
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.90263681
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87116273
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86922713
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.86099186
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.81423276
27DROSHA_22980978_ChIP-Seq_HELA_Human1.80761139
28* CJUN_26792858_Chip-Seq_BT549_Human1.79824846
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76716273
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.76648811
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71543372
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70573762
33* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62134478
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.57531361
35TP53_16413492_ChIP-PET_HCT116_Human1.55185240
36BRD4_25478319_ChIP-Seq_HGPS_Human1.54260816
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.53818599
38* GBX2_23144817_ChIP-Seq_PC3_Human1.53738379
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52740753
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51316744
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51223139
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49578230
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49578230
44TP53_18474530_ChIP-ChIP_U2OS_Human1.49296343
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49279747
46* EZH2_27294783_Chip-Seq_ESCs_Mouse1.46445236
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43654264
48* EZH2_22144423_ChIP-Seq_EOC_Human1.43047172
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41945285
50* ISL1_27105846_Chip-Seq_CPCs_Mouse1.41792111
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39113853
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38246377
53* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37973006
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32718641
55* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31258352
56KDM2B_26808549_Chip-Seq_K562_Human1.30580062
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29338611
58* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28673407
59* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25818092
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25499950
61AHR_22903824_ChIP-Seq_MCF-7_Human1.24415309
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20502524
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.19859032
64* RING1B_27294783_Chip-Seq_ESCs_Mouse1.19687408
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.19153334
66* SA1_22415368_ChIP-Seq_MEFs_Mouse1.18959848
67* TP53_23651856_ChIP-Seq_MEFs_Mouse1.16589762
68* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16090987
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16056563
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15696800
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15644456
72AR_21572438_ChIP-Seq_LNCaP_Human1.14434793
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13975007
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13525812
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13260933
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.12710638
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12659738
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.12140133
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.11678130
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.10302547
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10135750
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.09617753
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09139650
84CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08021081
85RXR_22108803_ChIP-Seq_LS180_Human1.07987901
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06772721
87SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04575432
88* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03564652
89TBX20_22080862_ChIP-Seq_HEART_Mouse1.03550250
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.03550250
91STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98904595
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98589747
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98282116
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.97681271
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97501151
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97144246
97* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96594913
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96386189
99* AR_19668381_ChIP-Seq_PC3_Human0.94848215
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94738092
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.94050846
102NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93922379
103BCAT_22108803_ChIP-Seq_LS180_Human0.92615165
104* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90780863
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.89855355
106* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89363605
107* SMAD4_21799915_ChIP-Seq_A2780_Human0.89034195
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88616998
109ERG_21242973_ChIP-ChIP_JURKAT_Human0.88091092
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86229963
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84688333
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83590799
113KDM2B_26808549_Chip-Seq_REH_Human0.82973945
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82933359
115TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81448771
116* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80840372
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80662163
118* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80371442
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.79902443
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79268382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.61455416
2MP0005275_abnormal_skin_tensile5.51424131
3MP0005503_abnormal_tendon_morphology5.48293188
4MP0003705_abnormal_hypodermis_morpholog3.83280076
5MP0003279_aneurysm3.53661897
6MP0001958_emphysema3.28083643
7MP0004272_abnormal_basement_membrane3.00824077
8MP0005623_abnormal_meninges_morphology2.46848335
9MP0005257_abnormal_intraocular_pressure2.30405654
10MP0009384_cardiac_valve_regurgitation2.30006695
11MP0005508_abnormal_skeleton_morphology2.17031597
12MP0006054_spinal_hemorrhage2.05162267
13MP0002108_abnormal_muscle_morphology1.97852697
14MP0003283_abnormal_digestive_organ1.91943857
15MP0002060_abnormal_skin_morphology1.85676817
16MP0003385_abnormal_body_wall1.83910046
17MP0003045_fibrosis1.75992211
18MP0009250_abnormal_appendicular_skeleto1.66554879
19MP0000751_myopathy1.66505252
20MP0003566_abnormal_cell_adhesion1.62125468
21MP0001299_abnormal_eye_distance/1.59188559
22* MP0002295_abnormal_pulmonary_circulatio1.57172882
23MP0003091_abnormal_cell_migration1.54206930
24MP0000013_abnormal_adipose_tissue1.49905600
25MP0005023_abnormal_wound_healing1.44691760
26MP0000534_abnormal_ureter_morphology1.41612594
27MP0002896_abnormal_bone_mineralization1.38742755
28MP0003942_abnormal_urinary_system1.38295849
29MP0010030_abnormal_orbit_morphology1.36269309
30MP0000428_abnormal_craniofacial_morphol1.30087525
31MP0003115_abnormal_respiratory_system1.28233217
32MP0004859_abnormal_synaptic_plasticity1.24518541
33MP0005076_abnormal_cell_differentiation1.23863810
34MP0004134_abnormal_chest_morphology1.23815927
35MP0002168_other_aberrant_phenotype1.22808451
36MP0009780_abnormal_chondrocyte_physiolo1.21361033
37MP0000733_abnormal_muscle_development1.21236189
38MP0003122_maternal_imprinting1.19983643
39MP0005171_absent_coat_pigmentation1.19336474
40MP0010352_gastrointestinal_tract_polyps1.18424586
41MP0005670_abnormal_white_adipose1.18060514
42MP0009053_abnormal_anal_canal1.17891016
43MP0001879_abnormal_lymphatic_vessel1.17560451
44MP0000003_abnormal_adipose_tissue1.16875679
45MP0001243_abnormal_dermal_layer1.16674706
46MP0000767_abnormal_smooth_muscle1.13002485
47MP0002282_abnormal_trachea_morphology1.10014865
48MP0002115_abnormal_skeleton_extremities1.06748057
49MP0002932_abnormal_joint_morphology1.05686642
50MP0000163_abnormal_cartilage_morphology1.05288062
51MP0004233_abnormal_muscle_weight1.04671132
52MP0005390_skeleton_phenotype1.02453225
53MP0005375_adipose_tissue_phenotype1.02452921
54MP0003941_abnormal_skin_development1.02367060
55MP0010368_abnormal_lymphatic_system0.99627305
56MP0000049_abnormal_middle_ear0.97665686
57MP0002837_dystrophic_cardiac_calcinosis0.96436950
58MP0004084_abnormal_cardiac_muscle0.95932466
59MP0002089_abnormal_postnatal_growth/wei0.95255156
60MP0003950_abnormal_plasma_membrane0.94525354
61MP0001542_abnormal_bone_strength0.93637092
62MP0004858_abnormal_nervous_system0.93156158
63MP0003755_abnormal_palate_morphology0.92939445
64MP0004185_abnormal_adipocyte_glucose0.89048432
65MP0001348_abnormal_lacrimal_gland0.87877847
66MP0005595_abnormal_vascular_smooth0.87756971
67MP0000750_abnormal_muscle_regeneration0.86003021
68MP0005666_abnormal_adipose_tissue0.85846534
69MP0002116_abnormal_craniofacial_bone0.84506809
70MP0002113_abnormal_skeleton_development0.83827425
71MP0002249_abnormal_larynx_morphology0.83403867
72MP0000538_abnormal_urinary_bladder0.82840742
73* MP0000759_abnormal_skeletal_muscle0.82824424
74MP0000537_abnormal_urethra_morphology0.82795436
75MP0000681_abnormal_thyroid_gland0.82505838
76MP0006138_congestive_heart_failure0.82029777
77MP0002998_abnormal_bone_remodeling0.81965908
78MP0003935_abnormal_craniofacial_develop0.78980243
79MP0004130_abnormal_muscle_cell0.77918936
80MP0002109_abnormal_limb_morphology0.75881438
81MP0004087_abnormal_muscle_fiber0.73960135
82MP0001270_distended_abdomen0.72994353
83MP0000432_abnormal_head_morphology0.71439091
84MP0004145_abnormal_muscle_electrophysio0.71023158
85MP0005369_muscle_phenotype0.70745675
86MP0001849_ear_inflammation0.69628253
87MP0005620_abnormal_muscle_contractility0.69421093
88MP0002114_abnormal_axial_skeleton0.69270213
89MP0000569_abnormal_digit_pigmentation0.68927183
90* MP0002128_abnormal_blood_circulation0.68490557
91MP0002933_joint_inflammation0.67489256
92MP0004036_abnormal_muscle_relaxation0.67343743
93MP0001175_abnormal_lung_morphology0.67265972
94* MP0001177_atelectasis0.66320397
95MP0002925_abnormal_cardiovascular_devel0.66316777
96MP0002971_abnormal_brown_adipose0.66276703
97* MP0002133_abnormal_respiratory_system0.66034360
98* MP0005388_respiratory_system_phenotype0.66034360
99MP0001614_abnormal_blood_vessel0.65865538
100MP0002127_abnormal_cardiovascular_syste0.65743435
101MP0003937_abnormal_limbs/digits/tail_de0.65111388
102MP0005409_darkened_coat_color0.63985340
103MP0005164_abnormal_response_to0.63216115
104MP0000467_abnormal_esophagus_morphology0.62217088
105MP0000516_abnormal_urinary_system0.61839072
106MP0005367_renal/urinary_system_phenotyp0.61839072
107MP0000762_abnormal_tongue_morphology0.60923452
108MP0000462_abnormal_digestive_system0.60840385
109MP0002233_abnormal_nose_morphology0.60453698
110MP0002234_abnormal_pharynx_morphology0.60198122
111MP0004883_abnormal_blood_vessel0.59700400
112MP0002111_abnormal_tail_morphology0.59013203
113MP0010386_abnormal_urinary_bladder0.59003033
114MP0002638_abnormal_pupillary_reflex0.57230721
115MP0000230_abnormal_systemic_arterial0.57111226
116MP0000749_muscle_degeneration0.55668356
117MP0005385_cardiovascular_system_phenoty0.52053853
118MP0001544_abnormal_cardiovascular_syste0.52053853
119MP0005197_abnormal_uvea_morphology0.50046742

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.36907344
2Premature rupture of membranes (HP:0001788)7.42025588
3Shallow orbits (HP:0000586)5.42741392
4Broad metatarsal (HP:0001783)5.42296075
5Ankle contracture (HP:0006466)5.13331133
6Aortic dissection (HP:0002647)5.03030229
7Soft skin (HP:0000977)4.57804406
8Atrophic scars (HP:0001075)4.23208641
9Aortic aneurysm (HP:0004942)4.20593707
10Peritonitis (HP:0002586)4.19120112
11Cerebral aneurysm (HP:0004944)4.17902543
12Bladder diverticulum (HP:0000015)4.17112292
13Fragile skin (HP:0001030)3.99089663
14Dilatation of the ascending aorta (HP:0005111)3.84462975
15Cervical subluxation (HP:0003308)3.53295602
16Mitral valve prolapse (HP:0001634)3.48175936
17Follicular hyperkeratosis (HP:0007502)3.47422402
18Wrist flexion contracture (HP:0001239)3.44774822
19Abnormality of dentin (HP:0010299)3.44063380
20Genu recurvatum (HP:0002816)3.43252082
21Type 1 muscle fiber predominance (HP:0003803)3.37839824
22Blue sclerae (HP:0000592)3.08708905
23Bowel diverticulosis (HP:0005222)3.07945814
24Wormian bones (HP:0002645)3.04077567
25Increased connective tissue (HP:0009025)3.03669075
26Vertebral compression fractures (HP:0002953)3.03239666
27Neonatal short-limb short stature (HP:0008921)3.02471343
28Hyperextensible skin (HP:0000974)3.01987020
29Spinal rigidity (HP:0003306)2.94338347
30Biconcave vertebral bodies (HP:0004586)2.94321257
31Vascular tortuosity (HP:0004948)2.90838132
32Aortic valve stenosis (HP:0001650)2.80954813
33Overgrowth (HP:0001548)2.79169187
34Slender build (HP:0001533)2.75989553
35Increased variability in muscle fiber diameter (HP:0003557)2.64663055
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60293491
37Short 4th metacarpal (HP:0010044)2.60293491
38Mild short stature (HP:0003502)2.59843754
39Coronal craniosynostosis (HP:0004440)2.59688811
40Infantile muscular hypotonia (HP:0008947)2.58551274
41Aneurysm (HP:0002617)2.57155790
42Arterial tortuosity (HP:0005116)2.55198932
43Wide anterior fontanel (HP:0000260)2.55158300
44Deviation of the hallux (HP:0010051)2.54782855
45Joint laxity (HP:0001388)2.53906308
46Joint stiffness (HP:0001387)2.53186261
47Striae distensae (HP:0001065)2.44373056
48Spondylolisthesis (HP:0003302)2.42837010
49Pulmonary artery stenosis (HP:0004415)2.38630608
50Hallux valgus (HP:0001822)2.36444901
51Broad ribs (HP:0000885)2.35065377
52Buphthalmos (HP:0000557)2.31790938
53Ectopia lentis (HP:0001083)2.30893269
54Mildly elevated creatine phosphokinase (HP:0008180)2.28079204
55Abnormal delivery (HP:0001787)2.26587269
56Narrow nasal bridge (HP:0000446)2.24862376
57Camptodactyly of toe (HP:0001836)2.24645437
58Abnormality of the 4th metacarpal (HP:0010012)2.23943146
59Abnormality of the acetabulum (HP:0003170)2.21778082
60Hypoplasia of the iris (HP:0007676)2.19572716
61Abnormality of skeletal muscle fiber size (HP:0012084)2.19470668
62Mesomelia (HP:0003027)2.18548924
63Redundant skin (HP:0001582)2.17037547
64Elbow flexion contracture (HP:0002987)2.13548658
65Hypoventilation (HP:0002791)2.12857642
66Limited hip movement (HP:0008800)2.11998420
67Ovoid vertebral bodies (HP:0003300)2.09022447
68Turricephaly (HP:0000262)2.08787118
69Bell-shaped thorax (HP:0001591)2.08783050
70Mitral regurgitation (HP:0001653)2.08616216
71Thin bony cortex (HP:0002753)2.06919823
72Ulnar bowing (HP:0003031)2.02452490
73Broad long bones (HP:0005622)2.01294537
74Venous insufficiency (HP:0005293)2.01103075
75Disproportionate tall stature (HP:0001519)1.96831403
76Round ear (HP:0100830)1.96711918
77Venous abnormality (HP:0002624)1.95922400
78Osteoarthritis (HP:0002758)1.95430389
79Abnormality of the peritoneum (HP:0002585)1.95214979
80Flat cornea (HP:0007720)1.93689710
81Morphological abnormality of the middle ear (HP:0008609)1.92122870
82Congenital glaucoma (HP:0001087)1.89377221
83Spinal cord lesions (HP:0100561)1.87408542
84Syringomyelia (HP:0003396)1.87408542
85Obstructive sleep apnea (HP:0002870)1.87245744
86Persistence of primary teeth (HP:0006335)1.87072289
87Inguinal hernia (HP:0000023)1.84466833
88Protruding ear (HP:0000411)1.84412609
89Narrow palate (HP:0000189)1.84281329
90Natal tooth (HP:0000695)1.83997737
91Enlarged penis (HP:0000040)1.82636801
92Tarsal synostosis (HP:0008368)1.82566431
93Hip contracture (HP:0003273)1.82512979
94Osteolytic defects of the hand bones (HP:0009699)1.81480459
95Osteolytic defects of the phalanges of the hand (HP:0009771)1.81480459
96Flared iliac wings (HP:0002869)1.80446408
97Emphysema (HP:0002097)1.80038566
98Mitral stenosis (HP:0001718)1.79786000
99Gingival overgrowth (HP:0000212)1.79631133
100Delayed closure of the anterior fontanelle (HP:0001476)1.79618443
101Knee flexion contracture (HP:0006380)1.79176626
102Hypoplasia of the odontoid process (HP:0003311)1.77646868
103Aortic regurgitation (HP:0001659)1.77077819
104Osteopenia (HP:0000938)1.72270486
105Abnormality of the parietal bone (HP:0002696)1.71009333
106Broad toe (HP:0001837)1.70208598
107Lymphangioma (HP:0100764)1.70031266
108Bronchomalacia (HP:0002780)1.69777846
109Breech presentation (HP:0001623)1.69582655
110Flexion contracture of toe (HP:0005830)1.68094188
111Joint contractures involving the joints of the feet (HP:0100492)1.68094188
112Tibial bowing (HP:0002982)1.68020073
113Abnormality of skull ossification (HP:0002703)1.67828725
114Femoral bowing (HP:0002980)1.66521277
115Delayed cranial suture closure (HP:0000270)1.66421549
116Long toe (HP:0010511)1.64389601
117Renal duplication (HP:0000075)1.64245168
118Abnormality of the odontoid process (HP:0003310)1.64086361
119Arachnodactyly (HP:0001166)1.62609423
120Abnormality of the anterior chamber (HP:0000593)1.62288963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.66877586
2PDGFRA3.93523521
3TRIB33.74494110
4LATS13.30152978
5LATS23.25425872
6TTN2.96534548
7EPHB22.79757537
8SIK12.69614185
9ERN12.52592887
10RIPK12.35989271
11PKN22.13392852
12NTRK31.96920870
13DMPK1.94913758
14KIT1.85878997
15CAMK1D1.83948740
16FER1.79004140
17EPHA31.76179378
18PAK21.76162085
19AKT31.75168478
20BMX1.74083672
21MAP3K61.71477658
22EPHA41.71379172
23PTK21.67107232
24CAMK1G1.65916449
25PTK2B1.64944800
26MARK11.58214485
27FGFR11.51916288
28PRKD31.51795507
29PDGFRB1.49400729
30GRK51.45543656
31PAK31.40984905
32NTRK11.39111845
33MAPK71.33280913
34TGFBR21.28500440
35MYLK1.26324082
36FGFR21.20107283
37ICK1.18822190
38FLT31.17914474
39MTOR1.11785234
40MARK21.09759525
41PLK21.05883449
42PRKD21.04418989
43TIE11.03750427
44KSR11.01992027
45PRKCH0.98777288
46PAK60.98578012
47PIK3CG0.94545792
48PTK60.94250511
49ROCK10.93800375
50PIK3CA0.93469723
51LMTK20.91316551
52PAK40.89707301
53STK30.89610524
54CDC42BPA0.88067298
55MET0.84479635
56RET0.82317432
57STK380.79378941
58LIMK10.78139931
59CAMKK10.76865947
60MAP2K10.76440793
61WNK10.76154685
62GRK10.76109790
63PRPF4B0.73496037
64TGFBR10.71686301
65EEF2K0.69762081
66TAOK10.68899266
67TRPM70.66647416
68PRKD10.66559572
69ILK0.65819593
70INSR0.65366935
71DAPK30.64627241
72KSR20.64061532
73TYRO30.63392953
74MAPK40.63172781
75MAP3K100.61583472
76ROCK20.59140094
77CDK120.59098357
78MAPK120.58760395
79ADRBK20.58390276
80RPS6KC10.56594063
81RPS6KL10.56594063
82MOS0.56356455
83FGFR40.56139665
84SRC0.55907844
85MAP3K70.55422368
86MAPKAPK30.55021588
87CASK0.54781242
88GSK3A0.53829397
89PINK10.51583738
90NLK0.51261677
91CAMK10.49881965
92MINK10.48451404
93TAOK20.48014593
94EPHB10.47763740
95PKN10.47272798
96ABL20.47074094
97RPS6KA60.46869444
98MELK0.43890819
99JAK10.43306351
100ADRBK10.42264410
101SGK2230.41399517
102SGK4940.41399517
103PRKCE0.41213315
104DAPK20.40847067
105CAMK40.40752004
106CLK10.40207471
107CAMK2G0.39246049
108PRKG10.38355421
109NUAK10.38000722
110FYN0.37780907
111ERBB20.37602383
112LRRK20.36028548
113MAP2K30.35154040
114SCYL20.34684544
115GRK70.34423077
116CDK60.34337507
117PRKAA10.33173960
118MAP3K30.32795325
119MAP3K90.32455626
120PDPK10.32408905
121HIPK20.31914424
122FGFR30.31871248
123PRKCG0.31798663
124CDK140.31655339
125SGK20.31340475
126STK38L0.31149488
127NEK90.30403461
128IGF1R0.29834134
129MAPK10.29589029
130CDK50.29506986
131FRK0.29151297
132CDK150.29085367
133PAK10.28857543
134RPS6KA20.27933560
135CDK180.27511583
136TESK10.27081915
137PRKAA20.24801685
138MAPK80.24389025

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.67820076
2Focal adhesion_Homo sapiens_hsa045102.55388375
3Protein digestion and absorption_Homo sapiens_hsa049742.29000826
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04073220
5Basal cell carcinoma_Homo sapiens_hsa052172.00067005
6Dilated cardiomyopathy_Homo sapiens_hsa054141.96872911
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.94831993
8Proteoglycans in cancer_Homo sapiens_hsa052051.91031805
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86889365
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85449399
11Amoebiasis_Homo sapiens_hsa051461.79681658
12Adherens junction_Homo sapiens_hsa045201.78251337
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.78174463
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71369868
15Hedgehog signaling pathway_Homo sapiens_hsa043401.67485862
16Hippo signaling pathway_Homo sapiens_hsa043901.53957425
17TGF-beta signaling pathway_Homo sapiens_hsa043501.52975026
18Bladder cancer_Homo sapiens_hsa052191.44473338
19Glioma_Homo sapiens_hsa052141.42019375
20Melanoma_Homo sapiens_hsa052181.37132844
21* Axon guidance_Homo sapiens_hsa043601.33717025
22Wnt signaling pathway_Homo sapiens_hsa043101.33465312
23Melanogenesis_Homo sapiens_hsa049161.30392803
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30173887
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.29792579
26MicroRNAs in cancer_Homo sapiens_hsa052061.27767854
27Circadian entrainment_Homo sapiens_hsa047131.23428890
28Small cell lung cancer_Homo sapiens_hsa052221.22498768
29Malaria_Homo sapiens_hsa051441.20999546
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16853536
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15597335
32Rap1 signaling pathway_Homo sapiens_hsa040151.13704971
33GnRH signaling pathway_Homo sapiens_hsa049121.13679116
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12479616
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.10847525
36Estrogen signaling pathway_Homo sapiens_hsa049151.10419768
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08268054
38Chronic myeloid leukemia_Homo sapiens_hsa052201.08110870
39Oxytocin signaling pathway_Homo sapiens_hsa049211.05867569
40Renin secretion_Homo sapiens_hsa049241.05678022
41Amphetamine addiction_Homo sapiens_hsa050311.03828711
42Gap junction_Homo sapiens_hsa045401.03657151
43Pathways in cancer_Homo sapiens_hsa052001.01305266
44PPAR signaling pathway_Homo sapiens_hsa033201.00939189
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00303182
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.99755705
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99532588
48Salivary secretion_Homo sapiens_hsa049700.99450881
49Long-term potentiation_Homo sapiens_hsa047200.98742601
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98561199
51Cocaine addiction_Homo sapiens_hsa050300.96938478
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96115065
53cAMP signaling pathway_Homo sapiens_hsa040240.95528432
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95198459
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91989825
56mTOR signaling pathway_Homo sapiens_hsa041500.89906142
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89018519
58Cholinergic synapse_Homo sapiens_hsa047250.89012537
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.88346886
60Platelet activation_Homo sapiens_hsa046110.87619805
61Type II diabetes mellitus_Homo sapiens_hsa049300.85393544
62Prostate cancer_Homo sapiens_hsa052150.84469078
63Dorso-ventral axis formation_Homo sapiens_hsa043200.83545341
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83153056
65Calcium signaling pathway_Homo sapiens_hsa040200.82746671
66Tight junction_Homo sapiens_hsa045300.81158364
67Complement and coagulation cascades_Homo sapiens_hsa046100.81108945
68Dopaminergic synapse_Homo sapiens_hsa047280.80774104
69AMPK signaling pathway_Homo sapiens_hsa041520.80263837
70Gastric acid secretion_Homo sapiens_hsa049710.79082804
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78464379
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.77790581
73Ras signaling pathway_Homo sapiens_hsa040140.77437640
74Glutamatergic synapse_Homo sapiens_hsa047240.76969501
75Tyrosine metabolism_Homo sapiens_hsa003500.76297614
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.75149456
77Thyroid hormone synthesis_Homo sapiens_hsa049180.74247826
78Pancreatic cancer_Homo sapiens_hsa052120.73874148
79ErbB signaling pathway_Homo sapiens_hsa040120.73708949
80Endometrial cancer_Homo sapiens_hsa052130.69921240
81Insulin resistance_Homo sapiens_hsa049310.69758015
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69623888
83Ovarian steroidogenesis_Homo sapiens_hsa049130.69406747
84Colorectal cancer_Homo sapiens_hsa052100.69241136
85Insulin signaling pathway_Homo sapiens_hsa049100.69096367
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.68771544
87Viral myocarditis_Homo sapiens_hsa054160.67297860
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67054021
89Nicotine addiction_Homo sapiens_hsa050330.66772070
90VEGF signaling pathway_Homo sapiens_hsa043700.66706720
91MAPK signaling pathway_Homo sapiens_hsa040100.65756545
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65652305
93Long-term depression_Homo sapiens_hsa047300.64710143
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.63949714
95HIF-1 signaling pathway_Homo sapiens_hsa040660.63514257
96Glucagon signaling pathway_Homo sapiens_hsa049220.63153803
97Renin-angiotensin system_Homo sapiens_hsa046140.62643782
98Renal cell carcinoma_Homo sapiens_hsa052110.61596591
99Insulin secretion_Homo sapiens_hsa049110.60722290
100HTLV-I infection_Homo sapiens_hsa051660.60630927
101GABAergic synapse_Homo sapiens_hsa047270.59817419
102Morphine addiction_Homo sapiens_hsa050320.59046441
103Choline metabolism in cancer_Homo sapiens_hsa052310.58976440
104Notch signaling pathway_Homo sapiens_hsa043300.58764172
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58616829
106Olfactory transduction_Homo sapiens_hsa047400.56986802
107Endocytosis_Homo sapiens_hsa041440.56659841
108Circadian rhythm_Homo sapiens_hsa047100.55940761
109Other glycan degradation_Homo sapiens_hsa005110.55403175
110Prion diseases_Homo sapiens_hsa050200.54528696
111Lysosome_Homo sapiens_hsa041420.53183596
112Histidine metabolism_Homo sapiens_hsa003400.50270571
113Glycerolipid metabolism_Homo sapiens_hsa005610.50036678
114Pertussis_Homo sapiens_hsa051330.47980229
115Phenylalanine metabolism_Homo sapiens_hsa003600.43524478
116Thyroid cancer_Homo sapiens_hsa052160.40040702

Most similar genes based on co-expression Upload to Enrichr

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