SLITRK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)7.95811297
2postsynaptic membrane organization (GO:0001941)7.09444670
3presynaptic membrane organization (GO:0097090)6.91311046
4neuron cell-cell adhesion (GO:0007158)5.96170147
5neurotransmitter-gated ion channel clustering (GO:0072578)5.03290327
6neuronal action potential propagation (GO:0019227)4.64838217
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.47284980
8protein localization to synapse (GO:0035418)4.37153045
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35581913
10positive regulation of oligodendrocyte differentiation (GO:0048714)4.28840796
11C4-dicarboxylate transport (GO:0015740)4.21568599
12vocalization behavior (GO:0071625)4.14910493
13response to lipoprotein particle (GO:0055094)4.13109556
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.08282604
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05432756
16positive regulation of synapse assembly (GO:0051965)4.03608983
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.01455742
18central nervous system myelination (GO:0022010)3.98834825
19axon ensheathment in central nervous system (GO:0032291)3.98834825
20regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.96445399
21glutamate receptor signaling pathway (GO:0007215)3.85120993
22cellular response to cholesterol (GO:0071397)3.76497638
23somite development (GO:0061053)3.76004943
24startle response (GO:0001964)3.73184820
25membrane assembly (GO:0071709)3.59919719
26regulation of glutamate receptor signaling pathway (GO:1900449)3.53662119
27regulation of respiratory system process (GO:0044065)3.51622385
28synaptic transmission, glutamatergic (GO:0035249)3.48447076
29cerebral cortex radially oriented cell migration (GO:0021799)3.45566514
30cellular response to sterol (GO:0036315)3.44550921
31behavioral response to nicotine (GO:0035095)3.42974959
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42473365
33cell proliferation in forebrain (GO:0021846)3.38903058
34positive regulation of potassium ion transmembrane transport (GO:1901381)3.38144595
35short-term memory (GO:0007614)3.37925662
36DNA deamination (GO:0045006)3.37108749
37serine family amino acid catabolic process (GO:0009071)3.32299181
38protein heterotetramerization (GO:0051290)3.31385784
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.31088081
40positive regulation of mitochondrial fission (GO:0090141)3.30410002
41neuron-neuron synaptic transmission (GO:0007270)3.29649999
42regulation of neurotransmitter uptake (GO:0051580)3.28408138
43L-amino acid import (GO:0043092)3.26797808
44positive regulation of membrane potential (GO:0045838)3.25796679
45regulation of timing of cell differentiation (GO:0048505)3.25554207
46mechanosensory behavior (GO:0007638)3.23491693
47cellular potassium ion homeostasis (GO:0030007)3.22813636
48protein polyglutamylation (GO:0018095)3.21934720
49amino acid import (GO:0043090)3.19448774
50regulation of pigment cell differentiation (GO:0050932)3.19231567
51regulation of respiratory gaseous exchange (GO:0043576)3.17865018
52transmission of nerve impulse (GO:0019226)3.16378918
53otic vesicle formation (GO:0030916)3.16080726
54positive regulation of dendritic spine development (GO:0060999)3.16016861
55oligodendrocyte differentiation (GO:0048709)3.15510749
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14692292
57regulation of synapse assembly (GO:0051963)3.14462669
58sulfation (GO:0051923)3.11448738
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10590307
60negative regulation of glial cell differentiation (GO:0045686)3.03671488
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.03207144
62water-soluble vitamin biosynthetic process (GO:0042364)3.02112810
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01493503
64positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.00412131
65negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98159510
66cerebellar granule cell differentiation (GO:0021707)2.95191224
67righting reflex (GO:0060013)2.95186012
68regulation of synaptic transmission, glutamatergic (GO:0051966)2.94396851
69regulation of collateral sprouting (GO:0048670)2.94014059
70detection of light stimulus involved in visual perception (GO:0050908)2.90482333
71detection of light stimulus involved in sensory perception (GO:0050962)2.90482333
72pyrimidine nucleobase catabolic process (GO:0006208)2.89868328
73aggressive behavior (GO:0002118)2.89348097
74auditory behavior (GO:0031223)2.87257670
75response to histamine (GO:0034776)2.87136407
76regulation of development, heterochronic (GO:0040034)2.86896934
77prostate gland growth (GO:0060736)2.86517348
78regulation of postsynaptic membrane potential (GO:0060078)2.85521411
79synapse assembly (GO:0007416)2.84419715
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81017481
81positive regulation of neurotransmitter secretion (GO:0001956)2.80144873
82neurotransmitter uptake (GO:0001504)2.78956404
83glycosphingolipid biosynthetic process (GO:0006688)2.78740508
84regulation of oligodendrocyte differentiation (GO:0048713)2.78444170
85cranial nerve structural organization (GO:0021604)2.78042757
86serotonin metabolic process (GO:0042428)2.77250479
87negative regulation of neurotransmitter transport (GO:0051589)2.77249233
88retinal ganglion cell axon guidance (GO:0031290)2.77043354
89positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.76425310
90regulation of synapse structural plasticity (GO:0051823)2.76206661
91regulation of synaptic transmission, GABAergic (GO:0032228)2.75501554
92limb bud formation (GO:0060174)2.75218447
93platelet dense granule organization (GO:0060155)2.73936565
94negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.73703614
95primary amino compound metabolic process (GO:1901160)2.72848210
96lateral sprouting from an epithelium (GO:0060601)2.71954448
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70460647
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70208837
99negative regulation of mast cell activation (GO:0033004)2.69393219
100long-term synaptic potentiation (GO:0060291)2.68225611
101regulation of synaptic vesicle exocytosis (GO:2000300)2.67783099
102gamma-aminobutyric acid transport (GO:0015812)2.66767813
103neuron recognition (GO:0008038)2.66479469
104spinal cord development (GO:0021510)2.65662089
105response to pheromone (GO:0019236)2.65165967
106facial nerve structural organization (GO:0021612)2.63549962
107potassium ion import (GO:0010107)2.63333606
108generation of neurons (GO:0048699)2.62993691
109long-term memory (GO:0007616)2.62948952
110positive regulation of synapse maturation (GO:0090129)2.61691516
111nonmotile primary cilium assembly (GO:0035058)2.61551771
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60902512
113forebrain neuron differentiation (GO:0021879)2.60822039
114locomotory exploration behavior (GO:0035641)2.57706315
115mitochondrial respiratory chain complex I assembly (GO:0032981)2.57667114
116NADH dehydrogenase complex assembly (GO:0010257)2.57667114
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57667114
118negative regulation of protein localization to cell surface (GO:2000009)2.57441906
119long-chain fatty acid biosynthetic process (GO:0042759)2.55608416
120cranial nerve morphogenesis (GO:0021602)2.55541410
121preassembly of GPI anchor in ER membrane (GO:0016254)2.55273475
122developmental pigmentation (GO:0048066)2.54994905
123central nervous system projection neuron axonogenesis (GO:0021952)2.54665000
124central nervous system neuron axonogenesis (GO:0021955)2.53706353
125regulation of synapse maturation (GO:0090128)2.52606049
126adult walking behavior (GO:0007628)2.52576471
127regulation of dendritic spine development (GO:0060998)2.50627669
128negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50305397
129learning (GO:0007612)2.48499622
130regulation of inositol phosphate biosynthetic process (GO:0010919)2.48458170
131negative regulation of systemic arterial blood pressure (GO:0003085)2.48314454
132fucose catabolic process (GO:0019317)2.48308426
133L-fucose metabolic process (GO:0042354)2.48308426
134L-fucose catabolic process (GO:0042355)2.48308426
135regulation of glomerulus development (GO:0090192)2.47810129
136cilium morphogenesis (GO:0060271)2.47510389
137negative regulation of neurotransmitter secretion (GO:0046929)2.47408092
138regulation of synapse organization (GO:0050807)2.46590815
139negative regulation of execution phase of apoptosis (GO:1900118)2.46582581
140limb development (GO:0060173)2.46126691
141appendage development (GO:0048736)2.46126691
142dendritic spine morphogenesis (GO:0060997)2.45886520
143positive regulation of glomerulus development (GO:0090193)2.45797964
144regulation of action potential (GO:0098900)2.45690355
145fear response (GO:0042596)2.45594104
146alanine transport (GO:0032328)2.45483503
147regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45151313
148behavioral fear response (GO:0001662)2.44936755
149dentate gyrus development (GO:0021542)2.44480460
150exploration behavior (GO:0035640)2.43160517
151dendrite development (GO:0016358)2.41940868
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.40114460
153positive regulation of protein kinase C signaling (GO:0090037)2.39341977
154mannosylation (GO:0097502)2.38272590
155membrane hyperpolarization (GO:0060081)2.37723304
156positive regulation of dendritic spine morphogenesis (GO:0061003)2.37403969
157response to auditory stimulus (GO:0010996)2.36910807
158sympathetic nervous system development (GO:0048485)2.36125889
159regulation of protein kinase A signaling (GO:0010738)2.35967184
160photoreceptor cell differentiation (GO:0046530)2.35610807
161eye photoreceptor cell differentiation (GO:0001754)2.35610807
162retina layer formation (GO:0010842)2.35309871
163synaptic vesicle exocytosis (GO:0016079)2.34116319
164calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32499351
165positive regulation of action potential (GO:0045760)2.32029824
166negative regulation of astrocyte differentiation (GO:0048712)2.31703323
167behavioral defense response (GO:0002209)2.30287602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.48333693
2GBX2_23144817_ChIP-Seq_PC3_Human4.23541951
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11035403
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79463569
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.76144549
6TAF15_26573619_Chip-Seq_HEK293_Human2.70190889
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70134219
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69389334
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.64035921
10ZNF274_21170338_ChIP-Seq_K562_Hela2.62829309
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58651183
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57312058
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47133628
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42996000
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32654983
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32654983
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31199882
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.31166665
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20908250
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06861928
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05507088
22AR_21572438_ChIP-Seq_LNCaP_Human2.04067591
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.03732866
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.01513962
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97620282
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.95906791
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95195778
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95185203
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94811999
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92027761
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89539433
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87594332
33P300_19829295_ChIP-Seq_ESCs_Human1.86633493
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.86184168
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84048025
36IGF1R_20145208_ChIP-Seq_DFB_Human1.72252033
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69898582
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68390685
39FUS_26573619_Chip-Seq_HEK293_Human1.67842879
40* RNF2_27304074_Chip-Seq_NSC_Mouse1.65347491
41REST_21632747_ChIP-Seq_MESCs_Mouse1.63703401
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.60525711
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59034936
44SMAD4_21799915_ChIP-Seq_A2780_Human1.57302449
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56847645
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.56704423
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.56032628
48VDR_22108803_ChIP-Seq_LS180_Human1.54126625
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54039798
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54021627
51ER_23166858_ChIP-Seq_MCF-7_Human1.51586437
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.50898170
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50674830
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47117406
55BCAT_22108803_ChIP-Seq_LS180_Human1.44725950
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43971157
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43926383
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42573501
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.39876544
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39661969
61P53_22387025_ChIP-Seq_ESCs_Mouse1.37567195
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37441613
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.37431947
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36898169
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33076869
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30333440
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30119087
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.29797058
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28414830
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27854307
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.27268269
72P300_18555785_Chip-Seq_ESCs_Mouse1.25929264
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24896926
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24746623
75CBP_20019798_ChIP-Seq_JUKART_Human1.24746623
76STAT3_18555785_Chip-Seq_ESCs_Mouse1.24522663
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23577401
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22915565
79AR_25329375_ChIP-Seq_VCAP_Human1.22016805
80NMYC_18555785_Chip-Seq_ESCs_Mouse1.20731694
81RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19011071
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17830777
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17601703
84TP53_18474530_ChIP-ChIP_U2OS_Human1.16451359
85SOX2_18555785_Chip-Seq_ESCs_Mouse1.16409216
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.15642329
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15482265
88RUNX2_22187159_ChIP-Seq_PCA_Human1.15450395
89EWS_26573619_Chip-Seq_HEK293_Human1.15030475
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14441367
91IRF1_19129219_ChIP-ChIP_H3396_Human1.13841572
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13464043
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.12502627
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.12418094
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11757039
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11662781
97JUN_21703547_ChIP-Seq_K562_Human1.10643715
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.10563923
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10337632
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.10318437
101DROSHA_22980978_ChIP-Seq_HELA_Human1.10278531
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08910938
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08180076
104STAT3_23295773_ChIP-Seq_U87_Human1.07814001
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07153064
106* TCF4_22108803_ChIP-Seq_LS180_Human1.06350467
107AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05778880
108SOX2_19829295_ChIP-Seq_ESCs_Human1.05314936
109NANOG_19829295_ChIP-Seq_ESCs_Human1.05314936
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04955581
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04693695
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04693695
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.04682876
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04234210
115RING1B_27294783_Chip-Seq_ESCs_Mouse1.04109226
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03588949
117KDM2B_26808549_Chip-Seq_REH_Human1.02648790
118* TCF4_23295773_ChIP-Seq_U87_Human1.02470947
119KLF4_18555785_Chip-Seq_ESCs_Mouse1.01873748
120PU1_27457419_Chip-Seq_LIVER_Mouse1.01021515
121ZFX_18555785_Chip-Seq_ESCs_Mouse1.00255799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.24448170
2MP0003136_yellow_coat_color4.78670353
3MP0001188_hyperpigmentation3.71848313
4MP0005409_darkened_coat_color3.16961693
5MP0009379_abnormal_foot_pigmentation2.73705118
6MP0006292_abnormal_olfactory_placode2.71151026
7MP0001968_abnormal_touch/_nociception2.60832738
8MP0004381_abnormal_hair_follicle2.55538610
9MP0004859_abnormal_synaptic_plasticity2.53780127
10MP0009745_abnormal_behavioral_response2.46468582
11MP0003635_abnormal_synaptic_transmissio2.44360535
12MP0001486_abnormal_startle_reflex2.36226942
13MP0009046_muscle_twitch2.32770348
14MP0002653_abnormal_ependyma_morphology2.30903949
15MP0005423_abnormal_somatic_nervous2.28536579
16MP0005171_absent_coat_pigmentation2.27716295
17MP0002064_seizures2.17021009
18MP0004270_analgesia2.12392244
19MP0002272_abnormal_nervous_system2.10744218
20MP0000566_synostosis2.03615150
21MP0004142_abnormal_muscle_tone1.99709329
22MP0002736_abnormal_nociception_after1.99695925
23MP0002572_abnormal_emotion/affect_behav1.96393915
24MP0002067_abnormal_sensory_capabilities1.92072739
25MP0002063_abnormal_learning/memory/cond1.84931520
26MP0006276_abnormal_autonomic_nervous1.81531387
27MP0005646_abnormal_pituitary_gland1.80674654
28MP0002734_abnormal_mechanical_nocicepti1.76634078
29MP0004742_abnormal_vestibular_system1.74743386
30MP0000778_abnormal_nervous_system1.70678702
31MP0005174_abnormal_tail_pigmentation1.70022842
32MP0000015_abnormal_ear_pigmentation1.69892312
33MP0002557_abnormal_social/conspecific_i1.63808741
34MP0008877_abnormal_DNA_methylation1.63777497
35MP0001986_abnormal_taste_sensitivity1.60513140
36MP0002735_abnormal_chemical_nociception1.59597371
37MP0003938_abnormal_ear_development1.53641555
38MP0002638_abnormal_pupillary_reflex1.53464172
39MP0008872_abnormal_physiological_respon1.51365283
40MP0005645_abnormal_hypothalamus_physiol1.49682657
41MP0002184_abnormal_innervation1.44913294
42MP0002102_abnormal_ear_morphology1.44757661
43MP0001501_abnormal_sleep_pattern1.43389389
44MP0005551_abnormal_eye_electrophysiolog1.43365872
45MP0003119_abnormal_digestive_system1.42974844
46MP0001970_abnormal_pain_threshold1.42430870
47MP0001905_abnormal_dopamine_level1.42403039
48MP0000516_abnormal_urinary_system1.40236975
49MP0005367_renal/urinary_system_phenotyp1.40236975
50MP0001984_abnormal_olfaction1.39887580
51MP0000026_abnormal_inner_ear1.38475051
52MP0001440_abnormal_grooming_behavior1.37354606
53MP0008569_lethality_at_weaning1.32328894
54MP0008260_abnormal_autophagy1.31108703
55MP0002876_abnormal_thyroid_physiology1.30318107
56MP0001529_abnormal_vocalization1.26801659
57MP0000920_abnormal_myelination1.26039653
58MP0001963_abnormal_hearing_physiology1.25017147
59MP0000631_abnormal_neuroendocrine_gland1.24080970
60MP0001502_abnormal_circadian_rhythm1.23160816
61MP0002733_abnormal_thermal_nociception1.22029582
62MP0004885_abnormal_endolymph1.21676569
63MP0002837_dystrophic_cardiac_calcinosis1.19765800
64MP0004133_heterotaxia1.19381059
65MP0002751_abnormal_autonomic_nervous1.18427144
66MP0002234_abnormal_pharynx_morphology1.16334678
67MP0000049_abnormal_middle_ear1.15861686
68MP0003937_abnormal_limbs/digits/tail_de1.15708441
69MP0002882_abnormal_neuron_morphology1.15271841
70MP0005670_abnormal_white_adipose1.11977316
71MP0000013_abnormal_adipose_tissue1.11723502
72MP0001485_abnormal_pinna_reflex1.11476846
73MP0002752_abnormal_somatic_nervous1.11256926
74MP0000372_irregular_coat_pigmentation1.10574107
75MP0002095_abnormal_skin_pigmentation1.04853299
76MP0005253_abnormal_eye_physiology1.02515415
77MP0005389_reproductive_system_phenotype1.01732552
78MP0002282_abnormal_trachea_morphology1.01447044
79MP0003195_calcinosis1.00628532
80MP0002160_abnormal_reproductive_system1.00321353
81MP0002009_preneoplasia0.99813525
82MP0000383_abnormal_hair_follicle0.99444862
83MP0003879_abnormal_hair_cell0.98368014
84MP0001177_atelectasis0.97781808
85MP0000955_abnormal_spinal_cord0.97034676
86MP0006072_abnormal_retinal_apoptosis0.96094362
87MP0002277_abnormal_respiratory_mucosa0.95446542
88MP0002066_abnormal_motor_capabilities/c0.94766012
89MP0005187_abnormal_penis_morphology0.91734208
90MP0000569_abnormal_digit_pigmentation0.91292217
91MP0009053_abnormal_anal_canal0.90996617
92MP0002938_white_spotting0.90350722
93MP0002177_abnormal_outer_ear0.89735289
94MP0002249_abnormal_larynx_morphology0.89212327
95MP0005379_endocrine/exocrine_gland_phen0.87763577
96MP0004924_abnormal_behavior0.87713414
97MP0005386_behavior/neurological_phenoty0.87713414
98MP0002229_neurodegeneration0.86118102
99MP0003787_abnormal_imprinting0.85783522
100MP0005499_abnormal_olfactory_system0.84188277
101MP0005394_taste/olfaction_phenotype0.84188277
102MP0009250_abnormal_appendicular_skeleto0.83452266
103MP0003634_abnormal_glial_cell0.83335994
104MP0005391_vision/eye_phenotype0.83067754
105MP0001664_abnormal_digestion0.82431195
106MP0003724_increased_susceptibility_to0.82356871
107MP0004043_abnormal_pH_regulation0.81536336
108MP0003011_delayed_dark_adaptation0.79358630
109MP0002928_abnormal_bile_duct0.79335504
110MP0008789_abnormal_olfactory_epithelium0.78513635
111MP0000647_abnormal_sebaceous_gland0.77996010
112MP0000534_abnormal_ureter_morphology0.76249527
113MP0003283_abnormal_digestive_organ0.75928085
114MP0002152_abnormal_brain_morphology0.74779128
115MP0000681_abnormal_thyroid_gland0.72598629
116MP0003941_abnormal_skin_development0.69684436
117MP0003633_abnormal_nervous_system0.69321737
118MP0002822_catalepsy0.68152773
119MP0004145_abnormal_muscle_electrophysio0.66519253
120MP0002163_abnormal_gland_morphology0.66283196
121MP0005195_abnormal_posterior_eye0.64820469
122MP0005075_abnormal_melanosome_morpholog0.64611975
123MP0001346_abnormal_lacrimal_gland0.64225548
124MP0003631_nervous_system_phenotype0.62104389
125MP0003690_abnormal_glial_cell0.60895361
126MP0004811_abnormal_neuron_physiology0.60579562
127MP0003315_abnormal_perineum_morphology0.60227423
128MP0005595_abnormal_vascular_smooth0.60093512

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.84680466
2Febrile seizures (HP:0002373)3.74669659
3Abnormality of the axillary hair (HP:0100134)3.63098366
4Abnormality of secondary sexual hair (HP:0009888)3.63098366
5Epileptic encephalopathy (HP:0200134)3.55795012
6Hyperventilation (HP:0002883)3.46374825
7Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.41515837
8Short 1st metacarpal (HP:0010034)3.41515837
9Pancreatic cysts (HP:0001737)3.33721406
10Split foot (HP:0001839)3.09162423
11Molar tooth sign on MRI (HP:0002419)2.99805237
12Abnormality of midbrain morphology (HP:0002418)2.99805237
13Broad-based gait (HP:0002136)2.97441619
14Abnormality of the 1st metacarpal (HP:0010009)2.96804445
15Parakeratosis (HP:0001036)2.92080517
16Increased corneal curvature (HP:0100692)2.89724498
17Keratoconus (HP:0000563)2.89724498
18Atonic seizures (HP:0010819)2.89281574
19Abolished electroretinogram (ERG) (HP:0000550)2.88678376
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.88374578
21Absent/shortened dynein arms (HP:0200106)2.88374578
22Sex reversal (HP:0012245)2.87006317
23Abnormal sex determination (HP:0012244)2.87006317
24Hemiplegia (HP:0002301)2.85632245
25Thyroid-stimulating hormone excess (HP:0002925)2.84350489
26Nonprogressive disorder (HP:0003680)2.83953002
27Optic nerve hypoplasia (HP:0000609)2.80688430
28Abnormality of the proximal phalanges of the hand (HP:0009834)2.77456402
29Abnormal ciliary motility (HP:0012262)2.75241314
30Abnormality of the middle phalanges of the toes (HP:0010183)2.71458778
31Stenosis of the external auditory canal (HP:0000402)2.70248159
32Focal seizures (HP:0007359)2.69570309
33Short phalanx of the thumb (HP:0009660)2.69260165
34Aplasia/Hypoplasia of the hallux (HP:0008362)2.64159228
35Hypothermia (HP:0002045)2.63707732
36Short hallux (HP:0010109)2.62737412
37Optic disc pallor (HP:0000543)2.60272865
38Megalencephaly (HP:0001355)2.57699868
39Nephronophthisis (HP:0000090)2.57225821
40Gaze-evoked nystagmus (HP:0000640)2.56391818
41Septo-optic dysplasia (HP:0100842)2.56130640
42Congenital stationary night blindness (HP:0007642)2.55364595
43Pendular nystagmus (HP:0012043)2.51237539
44Type I transferrin isoform profile (HP:0003642)2.48372318
45Medial flaring of the eyebrow (HP:0010747)2.43662106
46Absent septum pellucidum (HP:0001331)2.43440109
47Chorioretinal atrophy (HP:0000533)2.40420896
48Progressive cerebellar ataxia (HP:0002073)2.39797741
49Myokymia (HP:0002411)2.39702420
50Abnormal respiratory epithelium morphology (HP:0012253)2.35377152
51Abnormal respiratory motile cilium morphology (HP:0005938)2.35377152
52True hermaphroditism (HP:0010459)2.35241274
53Stomach cancer (HP:0012126)2.31453310
54Hyperglycinemia (HP:0002154)2.29089565
55Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.28830951
56Peripheral hypomyelination (HP:0007182)2.28283032
57Ulnar claw (HP:0001178)2.28215353
58Attenuation of retinal blood vessels (HP:0007843)2.26257091
59Absent speech (HP:0001344)2.24719461
60Abnormality of the septum pellucidum (HP:0007375)2.23248226
61Abnormal respiratory motile cilium physiology (HP:0012261)2.23074038
62Long nose (HP:0003189)2.22919772
63Progressive inability to walk (HP:0002505)2.22914769
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21575456
65Abnormality of alanine metabolism (HP:0010916)2.21575456
66Hyperalaninemia (HP:0003348)2.21575456
67Abnormality of the renal medulla (HP:0100957)2.20020058
68Dialeptic seizures (HP:0011146)2.19832858
69Action tremor (HP:0002345)2.19004920
70Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18042649
71Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.17559837
72Hemiparesis (HP:0001269)2.16513986
73White forelock (HP:0002211)2.16403088
74Abnormality of the nasal septum (HP:0000419)2.16282638
75Synostosis of carpal bones (HP:0005048)2.15145318
76Type II lissencephaly (HP:0007260)2.15116715
77Adactyly (HP:0009776)2.14586565
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14438805
793-Methylglutaconic aciduria (HP:0003535)2.14296875
80Morphological abnormality of the middle ear (HP:0008609)2.12288585
81Patchy hypopigmentation of hair (HP:0011365)2.11668854
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11535309
83Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.11499351
84Renal Fanconi syndrome (HP:0001994)2.11002645
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10772110
86Methylmalonic acidemia (HP:0002912)2.10680004
87Abnormality of glycine metabolism (HP:0010895)2.10632374
88Abnormality of serine family amino acid metabolism (HP:0010894)2.10632374
89Gait imbalance (HP:0002141)2.09145632
90Decreased central vision (HP:0007663)2.08928275
91Excessive salivation (HP:0003781)2.08921639
92Drooling (HP:0002307)2.08921639
93Retinal dysplasia (HP:0007973)2.08280609
94Genetic anticipation (HP:0003743)2.07983469
95Esotropia (HP:0000565)2.07848888
96Sclerocornea (HP:0000647)2.07015751
97Hypoplasia of the uterus (HP:0000013)2.06189900
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.05362437
99Amelogenesis imperfecta (HP:0000705)2.04862635
100Symphalangism affecting the phalanges of the hand (HP:0009773)2.04632914
101Aplasia/Hypoplasia of the tibia (HP:0005772)2.03285121
102Sensory axonal neuropathy (HP:0003390)2.01472294
103Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01173333
104Hyperglycinuria (HP:0003108)2.00597351
105Conical tooth (HP:0000698)2.00474756
106Humeroradial synostosis (HP:0003041)1.99721729
107Synostosis involving the elbow (HP:0003938)1.99721729
108Concave nail (HP:0001598)1.99398398
109Short tibia (HP:0005736)1.98823755
110Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98523387
111Abnormality of the renal cortex (HP:0011035)1.97934112
112Hypomagnesemia (HP:0002917)1.97551735
113Aplasia/hypoplasia of the uterus (HP:0008684)1.97370624
114Obstructive sleep apnea (HP:0002870)1.97152788
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.96704709
116Congenital primary aphakia (HP:0007707)1.96204449
117Renal cortical cysts (HP:0000803)1.96181524
118Abnormality of magnesium homeostasis (HP:0004921)1.95731003
119Metabolic alkalosis (HP:0200114)1.95518865
120Absence seizures (HP:0002121)1.95084683
121Alacrima (HP:0000522)1.94293792
122Hypoplasia of the ulna (HP:0003022)1.94293187
123Cystic liver disease (HP:0006706)1.94113371
124Acute necrotizing encephalopathy (HP:0006965)1.93957246
125Thickened helices (HP:0000391)1.93610123
126Pancreatic fibrosis (HP:0100732)1.92977723
127Congenital sensorineural hearing impairment (HP:0008527)1.92106850
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.90956710
129Postaxial hand polydactyly (HP:0001162)1.89842676
130Nephrogenic diabetes insipidus (HP:0009806)1.89495685
131Blue irides (HP:0000635)1.89423440
132Aplasia involving bones of the extremities (HP:0009825)1.89223986
133Aplasia involving bones of the upper limbs (HP:0009823)1.89223986
134Aplasia of the phalanges of the hand (HP:0009802)1.89223986
135Mitochondrial inheritance (HP:0001427)1.88072010
136Sleep apnea (HP:0010535)1.86715161
137Inability to walk (HP:0002540)1.86059649
138Specific learning disability (HP:0001328)1.85219402
139Tented upper lip vermilion (HP:0010804)1.84563541
140Abnormality of the renal collecting system (HP:0004742)1.83967596
141Abnormality of the phalanges of the 5th finger (HP:0004213)1.83038909
142Abnormal hair whorl (HP:0010721)1.82599693
143Postaxial foot polydactyly (HP:0001830)1.82344697
144Dysdiadochokinesis (HP:0002075)1.81649469
145Progressive macrocephaly (HP:0004481)1.81609522
146Abnormality of the phalanges of the 2nd finger (HP:0009541)1.81522877
147Dry hair (HP:0011359)1.81520708
148Decreased lacrimation (HP:0000633)1.80997143
149Abnormality of dental color (HP:0011073)1.80404052
150Reduced antithrombin III activity (HP:0001976)1.80179905
151Increased hepatocellular lipid droplets (HP:0006565)1.80169081
152Ectopic kidney (HP:0000086)1.79943860
153Preaxial hand polydactyly (HP:0001177)1.79880407
154Nasolacrimal duct obstruction (HP:0000579)1.79248770
155Protruding tongue (HP:0010808)1.78560280
156Abnormal rod and cone electroretinograms (HP:0008323)1.78338069
157Genital tract atresia (HP:0001827)1.76465309
158Vaginal atresia (HP:0000148)1.76128759
159Abnormality of binocular vision (HP:0011514)1.74611857
160Diplopia (HP:0000651)1.74611857
161Generalized tonic-clonic seizures (HP:0002069)1.73864248
162Severe visual impairment (HP:0001141)1.73422674

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.91975369
2TNIK4.46335618
3MUSK2.99365289
4FRK2.83187932
5MKNK22.78527581
6MAP2K72.36083278
7WNK32.24364000
8NTRK32.23972254
9EPHA42.05661389
10EPHA32.03622550
11PRPF4B2.02679544
12MAP4K21.93431010
13MAP3K121.74740301
14CDK191.73841363
15NUAK11.70999913
16TLK11.70698743
17MAPK131.68010872
18STK161.67249336
19FES1.57507773
20PAK61.50214194
21TRIM281.47198817
22TAOK31.44357993
23BCKDK1.43820555
24MKNK11.43340984
25PRKD21.37968227
26ERBB31.37530324
27YES11.36650607
28OXSR11.35981906
29IRAK21.31117988
30DYRK31.29196630
31NTRK21.29155303
32CLK11.29150413
33CDK31.22420137
34STK391.18945870
35MARK11.17056988
36FGR1.13881082
37ADRBK21.12463412
38NEK61.09627102
39PHKG21.07526561
40PHKG11.07526561
41IRAK11.07004566
42BMPR21.06892375
43NLK1.04973138
44ZAK1.04607553
45IRAK31.03986319
46IRAK41.01818221
47UHMK11.01700535
48CAMK2B1.01342486
49BMPR1B0.99469369
50ACVR1B0.98910391
51AKT30.96424756
52PRKD30.95304832
53CAMK2A0.93806504
54PKN10.92889630
55EIF2AK30.90708702
56MAP3K40.90638590
57GRK70.90457853
58WNK40.89311711
59EIF2AK20.85483005
60RIPK40.83519807
61GRK50.82464754
62STK380.82078676
63INSRR0.80899643
64RPS6KA40.79716669
65MST40.79669312
66TXK0.77854215
67PAK30.77764247
68SGK2230.76191928
69SGK4940.76191928
70DYRK1A0.74542120
71MAPK150.73983825
72BLK0.73478226
73SGK20.72452129
74PLK20.72143855
75PRKCE0.70814679
76PBK0.69765478
77CAMKK20.66393737
78PRKCG0.65322202
79CDK50.64381170
80FGFR20.63791380
81GRK10.63767031
82CAMK10.63353959
83TNK20.62176557
84MAPKAPK50.61972034
85DYRK20.61142280
86STK110.60403826
87PLK40.58266144
88BCR0.57546268
89CAMK2D0.56022960
90MINK10.55789965
91MAP2K40.55160433
92SRPK10.54168985
93CSNK1G10.53478128
94NEK90.51891442
95ERBB20.51047125
96ADRBK10.50948770
97CDK90.50946277
98RPS6KA50.50514993
99PNCK0.50373302
100NME10.48573512
101CAMK2G0.46762472
102VRK10.45398052
103MAP2K10.44992766
104CSNK1D0.44363874
105DAPK20.42481515
106ERBB40.42054770
107PRKG10.41446236
108PRKACA0.40922604
109HIPK20.40598527
110CCNB10.40358876
111SIK30.39945939
112CSNK1G20.39406775
113CAMK40.39095541
114MAPK120.38821257
115CSNK1G30.37551776
116PRKCA0.36605749
117IGF1R0.35243346
118CSNK1A1L0.33878541
119SGK10.33398143
120PRKCI0.33117973
121TEC0.32872777
122PINK10.32782986
123ROCK10.31935887
124NME20.31554427
125FER0.31374690
126PRKCZ0.31347044
127TIE10.31086164
128RPS6KA30.30795829
129PRKCQ0.30683344
130MAPKAPK30.30193971
131LYN0.30055783
132MAPK70.29867811
133SGK30.29084022
134CSNK1A10.29075623
135MARK20.26583579

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.27186174
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23254855
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52498970
4Phototransduction_Homo sapiens_hsa047442.48899348
5Nitrogen metabolism_Homo sapiens_hsa009102.48514749
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.43889710
7Morphine addiction_Homo sapiens_hsa050322.41591997
8Glutamatergic synapse_Homo sapiens_hsa047242.35612584
9GABAergic synapse_Homo sapiens_hsa047272.23053780
10Oxidative phosphorylation_Homo sapiens_hsa001902.15449603
11Butanoate metabolism_Homo sapiens_hsa006502.05890637
12Serotonergic synapse_Homo sapiens_hsa047261.97504842
13Taste transduction_Homo sapiens_hsa047421.96154842
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92407929
15Circadian entrainment_Homo sapiens_hsa047131.86417040
16Long-term depression_Homo sapiens_hsa047301.82960706
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.81016188
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76936010
19Sphingolipid metabolism_Homo sapiens_hsa006001.69962792
20Synaptic vesicle cycle_Homo sapiens_hsa047211.69272481
21Ether lipid metabolism_Homo sapiens_hsa005651.68933332
22Olfactory transduction_Homo sapiens_hsa047401.62391562
23Collecting duct acid secretion_Homo sapiens_hsa049661.60446541
24Salivary secretion_Homo sapiens_hsa049701.58274630
25Calcium signaling pathway_Homo sapiens_hsa040201.51049186
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49269265
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45812722
28Amphetamine addiction_Homo sapiens_hsa050311.44733371
29Axon guidance_Homo sapiens_hsa043601.44506555
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43475996
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41827168
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41535919
33Long-term potentiation_Homo sapiens_hsa047201.38626546
34Alzheimers disease_Homo sapiens_hsa050101.37882046
35Protein export_Homo sapiens_hsa030601.35914979
36Propanoate metabolism_Homo sapiens_hsa006401.35487749
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27894824
38Dopaminergic synapse_Homo sapiens_hsa047281.25122136
39Parkinsons disease_Homo sapiens_hsa050121.22972712
40Cholinergic synapse_Homo sapiens_hsa047251.21876897
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21451067
42Peroxisome_Homo sapiens_hsa041461.17473478
43Insulin secretion_Homo sapiens_hsa049111.16011415
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15420777
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11560688
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.08409079
47Rheumatoid arthritis_Homo sapiens_hsa053231.08028018
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.07523004
49Renin secretion_Homo sapiens_hsa049241.03396487
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03209135
51Cocaine addiction_Homo sapiens_hsa050301.03121144
52Ribosome_Homo sapiens_hsa030101.02689682
53Fatty acid elongation_Homo sapiens_hsa000621.02668167
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01789938
55Dorso-ventral axis formation_Homo sapiens_hsa043201.01713823
56Huntingtons disease_Homo sapiens_hsa050161.01192908
57Sulfur metabolism_Homo sapiens_hsa009200.99876069
58Chemical carcinogenesis_Homo sapiens_hsa052040.99538267
59Other glycan degradation_Homo sapiens_hsa005110.99527736
60Retinol metabolism_Homo sapiens_hsa008300.99292438
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98571817
62Graft-versus-host disease_Homo sapiens_hsa053320.97676576
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96793462
64Gastric acid secretion_Homo sapiens_hsa049710.96539633
65Tryptophan metabolism_Homo sapiens_hsa003800.96319240
66cAMP signaling pathway_Homo sapiens_hsa040240.95899760
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95151917
68Cardiac muscle contraction_Homo sapiens_hsa042600.95033204
69Melanogenesis_Homo sapiens_hsa049160.94717772
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93011158
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92678200
72Autoimmune thyroid disease_Homo sapiens_hsa053200.92281821
73Vibrio cholerae infection_Homo sapiens_hsa051100.89202629
74Wnt signaling pathway_Homo sapiens_hsa043100.87517040
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84016830
76Histidine metabolism_Homo sapiens_hsa003400.83856063
77beta-Alanine metabolism_Homo sapiens_hsa004100.83005046
78Caffeine metabolism_Homo sapiens_hsa002320.81970649
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.81445478
80Steroid biosynthesis_Homo sapiens_hsa001000.80471720
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80219069
82Fanconi anemia pathway_Homo sapiens_hsa034600.78239179
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77238980
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77135251
85Oxytocin signaling pathway_Homo sapiens_hsa049210.75686990
86Arachidonic acid metabolism_Homo sapiens_hsa005900.73496737
87RNA degradation_Homo sapiens_hsa030180.72252315
88Ras signaling pathway_Homo sapiens_hsa040140.70398878
89Glycerolipid metabolism_Homo sapiens_hsa005610.70324047
90Gap junction_Homo sapiens_hsa045400.70142893
91GnRH signaling pathway_Homo sapiens_hsa049120.68883646
92Basal cell carcinoma_Homo sapiens_hsa052170.67844324
93Circadian rhythm_Homo sapiens_hsa047100.67767406
94Pancreatic secretion_Homo sapiens_hsa049720.67657421
95Allograft rejection_Homo sapiens_hsa053300.65829846
96Asthma_Homo sapiens_hsa053100.64892411
97RNA polymerase_Homo sapiens_hsa030200.64164631
98African trypanosomiasis_Homo sapiens_hsa051430.63342942
99Regulation of autophagy_Homo sapiens_hsa041400.60285697
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60125496
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.59789970
102ErbB signaling pathway_Homo sapiens_hsa040120.59515194
103Basal transcription factors_Homo sapiens_hsa030220.58875414
104Fatty acid metabolism_Homo sapiens_hsa012120.58374654
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58366139
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56777014
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55974031
108Choline metabolism in cancer_Homo sapiens_hsa052310.55693308
109Selenocompound metabolism_Homo sapiens_hsa004500.54941960
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.54352097
111ABC transporters_Homo sapiens_hsa020100.54267225
112Type I diabetes mellitus_Homo sapiens_hsa049400.52385729
113PPAR signaling pathway_Homo sapiens_hsa033200.52268520
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52032983
115Hedgehog signaling pathway_Homo sapiens_hsa043400.51735249
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51338344
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50897301
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50439186
119MAPK signaling pathway_Homo sapiens_hsa040100.49786481
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49595153
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48721326
122Ovarian steroidogenesis_Homo sapiens_hsa049130.48491393
123Vitamin B6 metabolism_Homo sapiens_hsa007500.48476527
124Alcoholism_Homo sapiens_hsa050340.48301644
125Fat digestion and absorption_Homo sapiens_hsa049750.47465204
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47157939
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.46633147
128Hippo signaling pathway_Homo sapiens_hsa043900.43949529
129Homologous recombination_Homo sapiens_hsa034400.43876829
130Oocyte meiosis_Homo sapiens_hsa041140.43753236
131Thyroid hormone synthesis_Homo sapiens_hsa049180.42265928
132Sulfur relay system_Homo sapiens_hsa041220.41470883
133Phagosome_Homo sapiens_hsa041450.40445599
134Melanoma_Homo sapiens_hsa052180.40423908
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.39829432
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39240381
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38274849
138Malaria_Homo sapiens_hsa051440.38219159
139Hematopoietic cell lineage_Homo sapiens_hsa046400.34948179
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34847715
141Linoleic acid metabolism_Homo sapiens_hsa005910.34412924
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33870189
143Mineral absorption_Homo sapiens_hsa049780.33529186

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