SLITRK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.45289544
2vocalization behavior (GO:0071625)5.44126849
3neuron cell-cell adhesion (GO:0007158)5.39252676
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38853428
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.31415424
6locomotory exploration behavior (GO:0035641)5.25262588
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.19765897
8behavioral response to nicotine (GO:0035095)5.14753280
9protein localization to synapse (GO:0035418)5.13839192
10synaptic vesicle exocytosis (GO:0016079)5.10312134
11regulation of glutamate receptor signaling pathway (GO:1900449)4.93604157
12synaptic vesicle maturation (GO:0016188)4.93194087
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87053499
14glutamate receptor signaling pathway (GO:0007215)4.71170914
15glutamate secretion (GO:0014047)4.63112244
16exploration behavior (GO:0035640)4.51058312
17synaptic transmission, glutamatergic (GO:0035249)4.49875414
18neuronal action potential propagation (GO:0019227)4.42888907
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39562194
20dendritic spine morphogenesis (GO:0060997)4.38373224
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.32072531
22regulation of synaptic vesicle exocytosis (GO:2000300)4.28795301
23regulation of neuronal synaptic plasticity (GO:0048168)4.24798035
24neuron recognition (GO:0008038)4.22573254
25neuron-neuron synaptic transmission (GO:0007270)4.20603439
26neurotransmitter-gated ion channel clustering (GO:0072578)4.16919332
27layer formation in cerebral cortex (GO:0021819)4.03695446
28presynaptic membrane assembly (GO:0097105)4.02429208
29regulation of excitatory postsynaptic membrane potential (GO:0060079)3.94682729
30axonal fasciculation (GO:0007413)3.88775866
31neurotransmitter secretion (GO:0007269)3.88432449
32regulation of synaptic vesicle transport (GO:1902803)3.86123971
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.80111848
34postsynaptic membrane organization (GO:0001941)3.75854559
35regulation of dendritic spine morphogenesis (GO:0061001)3.75665098
36long-term memory (GO:0007616)3.75352108
37transmission of nerve impulse (GO:0019226)3.74904150
38regulation of postsynaptic membrane potential (GO:0060078)3.73712946
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.72782772
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68762797
41positive regulation of membrane potential (GO:0045838)3.67943766
42regulation of synapse structural plasticity (GO:0051823)3.67550829
43presynaptic membrane organization (GO:0097090)3.66317502
44gamma-aminobutyric acid transport (GO:0015812)3.64600255
45positive regulation of synapse maturation (GO:0090129)3.59960051
46serotonin metabolic process (GO:0042428)3.59120086
47regulation of synaptic plasticity (GO:0048167)3.57457195
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.56969001
49long-term synaptic potentiation (GO:0060291)3.51698866
50startle response (GO:0001964)3.51527203
51G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49128680
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.46437344
53central nervous system projection neuron axonogenesis (GO:0021952)3.45335059
54sulfation (GO:0051923)3.42616741
55response to histamine (GO:0034776)3.41364894
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.41314989
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39456792
58behavioral defense response (GO:0002209)3.39053464
59behavioral fear response (GO:0001662)3.39053464
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.38937519
61* dendrite morphogenesis (GO:0048813)3.33479821
62proline transport (GO:0015824)3.31310195
63positive regulation of potassium ion transmembrane transport (GO:1901381)3.31029838
64synaptic vesicle endocytosis (GO:0048488)3.30891487
65neuronal action potential (GO:0019228)3.30148454
66primary amino compound metabolic process (GO:1901160)3.30113876
67regulation of vesicle fusion (GO:0031338)3.30094102
68dendritic spine organization (GO:0097061)3.28512371
69neurotransmitter transport (GO:0006836)3.26716918
70negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.26390159
71pyrimidine nucleobase catabolic process (GO:0006208)3.25930018
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.25300368
73membrane depolarization (GO:0051899)3.23272354
74regulation of dendritic spine development (GO:0060998)3.22723141
75cellular potassium ion homeostasis (GO:0030007)3.21628365
76innervation (GO:0060384)3.20354911
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.20114630
78positive regulation of synapse assembly (GO:0051965)3.18619411
79learning (GO:0007612)3.17577422
80positive regulation of dendritic spine development (GO:0060999)3.15618229
81fear response (GO:0042596)3.14368824
82synapse assembly (GO:0007416)3.12284600
83G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11364988
84neuromuscular process controlling balance (GO:0050885)3.11200154
85regulation of glutamate secretion (GO:0014048)3.05787979
86positive regulation of dendritic spine morphogenesis (GO:0061003)3.03957411
87membrane depolarization during action potential (GO:0086010)3.02337932
88regulation of neurotransmitter secretion (GO:0046928)3.01699938
89regulation of neurotransmitter levels (GO:0001505)3.00485101
90mitochondrial respiratory chain complex I assembly (GO:0032981)3.00210600
91NADH dehydrogenase complex assembly (GO:0010257)3.00210600
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00210600
93synapse organization (GO:0050808)2.98364750
94protein polyglutamylation (GO:0018095)2.98325613
95mechanosensory behavior (GO:0007638)2.97419382
96membrane hyperpolarization (GO:0060081)2.96828532
97regulation of respiratory system process (GO:0044065)2.96633008
98neuronal ion channel clustering (GO:0045161)2.94841274
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93405374
100regulation of synaptic transmission (GO:0050804)2.93180868
101auditory behavior (GO:0031223)2.93111304
102neuromuscular process (GO:0050905)2.92365640
103positive regulation of neurotransmitter secretion (GO:0001956)2.92155267
104cerebellar Purkinje cell differentiation (GO:0021702)2.92102152
105dopamine transport (GO:0015872)2.91651417
106* synaptic transmission (GO:0007268)2.91402982
107response to auditory stimulus (GO:0010996)2.90360347
108activation of protein kinase A activity (GO:0034199)2.89718349
109retinal ganglion cell axon guidance (GO:0031290)2.86649506
110adult walking behavior (GO:0007628)2.86510083
111cochlea development (GO:0090102)2.86039643
112regulation of respiratory gaseous exchange (GO:0043576)2.84520649
113positive regulation of synaptic transmission (GO:0050806)2.84016894
114behavioral response to cocaine (GO:0048148)2.83973093
115cerebellar granule cell differentiation (GO:0021707)2.83139501
116neuromuscular synaptic transmission (GO:0007274)2.81903054
117action potential (GO:0001508)2.79546093
118somite development (GO:0061053)2.78232579
119nucleobase catabolic process (GO:0046113)2.77987848
120regulation of synapse maturation (GO:0090128)2.77911965
121detection of light stimulus involved in sensory perception (GO:0050962)2.75628277
122detection of light stimulus involved in visual perception (GO:0050908)2.75628277
123cell proliferation in forebrain (GO:0021846)2.74082838
124membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.71784008
125response to pheromone (GO:0019236)2.69171361
126dopamine biosynthetic process (GO:0042416)2.68672833
127potassium ion import (GO:0010107)2.68579785
128regulation of membrane repolarization (GO:0060306)2.67243558
129axon ensheathment in central nervous system (GO:0032291)2.65152562
130central nervous system myelination (GO:0022010)2.65152562
131protein complex biogenesis (GO:0070271)2.61868229
132fucose catabolic process (GO:0019317)2.61508300
133L-fucose metabolic process (GO:0042354)2.61508300
134L-fucose catabolic process (GO:0042355)2.61508300
135spinal cord development (GO:0021510)2.61093384
136water-soluble vitamin biosynthetic process (GO:0042364)2.60356469
137indole-containing compound metabolic process (GO:0042430)2.57001021
138negative regulation of astrocyte differentiation (GO:0048712)2.56886533
139detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55761954
140synaptic transmission, cholinergic (GO:0007271)2.55642667
141behavioral response to ethanol (GO:0048149)2.55452951
142membrane repolarization during action potential (GO:0086011)2.50116382
143nonmotile primary cilium assembly (GO:0035058)2.49334217
144response to amphetamine (GO:0001975)2.48344417
145multicellular organismal signaling (GO:0035637)2.46653212
146atrial cardiac muscle cell action potential (GO:0086014)2.46321257
147regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.46166300
148limb bud formation (GO:0060174)2.44351085
149regulation of neurotransmitter uptake (GO:0051580)2.43958094
150regulation of action potential (GO:0098900)2.43788982
151retinal cone cell development (GO:0046549)2.42999725
152mitochondrial respiratory chain complex assembly (GO:0033108)2.42236534

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.25841297
2GBX2_23144817_ChIP-Seq_PC3_Human3.84471499
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.23921089
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19639279
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12178491
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78531553
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78531553
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72608085
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67857745
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.66429200
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65619490
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55621873
13REST_21632747_ChIP-Seq_MESCs_Mouse2.51834304
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48125409
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.47331484
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41093905
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.29791257
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.24127622
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22812095
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.22748956
21DROSHA_22980978_ChIP-Seq_HELA_Human2.22362889
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18878039
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14617731
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05451436
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03141457
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.02233673
27* EWS_26573619_Chip-Seq_HEK293_Human2.02030007
28AR_21572438_ChIP-Seq_LNCaP_Human2.00813340
29* TAF15_26573619_Chip-Seq_HEK293_Human2.00304427
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99109175
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95682482
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91232974
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86123082
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85882684
35ZNF274_21170338_ChIP-Seq_K562_Hela1.81514426
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79419736
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70935642
38SMAD4_21799915_ChIP-Seq_A2780_Human1.68843945
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66079630
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61612518
41* P300_19829295_ChIP-Seq_ESCs_Human1.60490153
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59918409
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.57497198
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54302120
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52815998
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52479782
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49957873
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45727608
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.44073352
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41651528
51FUS_26573619_Chip-Seq_HEK293_Human1.41305459
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40648702
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.39558196
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38249507
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37935775
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37167090
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36314112
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35363290
59* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35160864
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.34770453
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34716528
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34205038
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.32844654
64IGF1R_20145208_ChIP-Seq_DFB_Human1.31009574
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.30856465
66* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28068643
67* AR_25329375_ChIP-Seq_VCAP_Human1.27985578
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27575716
69STAT3_23295773_ChIP-Seq_U87_Human1.27315394
70CBP_20019798_ChIP-Seq_JUKART_Human1.25625729
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25625729
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20556880
73* RNF2_27304074_Chip-Seq_NSC_Mouse1.20353078
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18486658
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.18439347
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17176085
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.14186425
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12383041
79TCF4_23295773_ChIP-Seq_U87_Human1.11794668
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11705764
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11343501
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11343501
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11150618
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10719162
85* AR_19668381_ChIP-Seq_PC3_Human1.10316398
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10000112
87* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09127177
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08340879
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08220548
90IRF1_19129219_ChIP-ChIP_H3396_Human1.07894251
91MYC_18940864_ChIP-ChIP_HL60_Human1.07108138
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06906152
93TP53_22573176_ChIP-Seq_HFKS_Human1.06010382
94* RUNX2_22187159_ChIP-Seq_PCA_Human1.05514669
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05017677
96AHR_22903824_ChIP-Seq_MCF-7_Human1.04940832
97* FLI1_21867929_ChIP-Seq_TH2_Mouse1.04844627
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04406634
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04196476
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03304708
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03016479
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02311275
103* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02204759
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01870351
105SOX9_26525672_Chip-Seq_HEART_Mouse1.01319561
106* JUN_21703547_ChIP-Seq_K562_Human1.01299658
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.01279035
108* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01070002
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99947925
110TAL1_26923725_Chip-Seq_HPCs_Mouse0.99409628
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98207120
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97997721
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96984182
114TP53_18474530_ChIP-ChIP_U2OS_Human0.96900732
115TP53_16413492_ChIP-PET_HCT116_Human0.95722198
116NANOG_18555785_Chip-Seq_ESCs_Mouse0.95314062
117VDR_22108803_ChIP-Seq_LS180_Human0.93598579
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93231225
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92705212
120BCAT_22108803_ChIP-Seq_LS180_Human0.92287958
121ER_23166858_ChIP-Seq_MCF-7_Human0.90055444
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.89589796
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.87896280
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87670249
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87173108
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85945948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.30627702
2MP0003880_abnormal_central_pattern5.59425530
3* MP0003635_abnormal_synaptic_transmissio4.03341265
4MP0004270_analgesia3.98118907
5* MP0009745_abnormal_behavioral_response3.38740942
6MP0002063_abnormal_learning/memory/cond3.30138942
7MP0002064_seizures3.10285697
8MP0001968_abnormal_touch/_nociception3.04077561
9* MP0002572_abnormal_emotion/affect_behav2.84265732
10MP0009046_muscle_twitch2.82726415
11MP0005423_abnormal_somatic_nervous2.73789911
12MP0001486_abnormal_startle_reflex2.64349978
13MP0002272_abnormal_nervous_system2.56923848
14MP0002734_abnormal_mechanical_nocicepti2.54692560
15MP0002736_abnormal_nociception_after2.52076128
16MP0000778_abnormal_nervous_system2.34794903
17MP0002735_abnormal_chemical_nociception2.31741241
18MP0006292_abnormal_olfactory_placode2.30779488
19MP0002822_catalepsy2.18224843
20MP0001501_abnormal_sleep_pattern2.13359383
21* MP0001440_abnormal_grooming_behavior2.12676900
22MP0002733_abnormal_thermal_nociception2.03378749
23MP0002184_abnormal_innervation1.99538470
24MP0002067_abnormal_sensory_capabilities1.97985502
25MP0008877_abnormal_DNA_methylation1.96819380
26MP0006276_abnormal_autonomic_nervous1.91625212
27MP0001529_abnormal_vocalization1.90275699
28MP0001970_abnormal_pain_threshold1.88923086
29MP0003329_amyloid_beta_deposits1.86379660
30MP0002557_abnormal_social/conspecific_i1.73404299
31MP0006072_abnormal_retinal_apoptosis1.71307476
32MP0005386_behavior/neurological_phenoty1.70157646
33MP0004924_abnormal_behavior1.70157646
34MP0000955_abnormal_spinal_cord1.61632215
35MP0004811_abnormal_neuron_physiology1.60372692
36MP0008569_lethality_at_weaning1.58045719
37MP0004858_abnormal_nervous_system1.55316492
38MP0002160_abnormal_reproductive_system1.52899638
39MP0001905_abnormal_dopamine_level1.52846714
40MP0001984_abnormal_olfaction1.52037046
41MP0002638_abnormal_pupillary_reflex1.49933551
42* MP0002882_abnormal_neuron_morphology1.47787986
43MP0009780_abnormal_chondrocyte_physiolo1.45873521
44MP0003879_abnormal_hair_cell1.42438722
45MP0005646_abnormal_pituitary_gland1.41651474
46MP0002066_abnormal_motor_capabilities/c1.40633361
47MP0003122_maternal_imprinting1.40448661
48MP0005253_abnormal_eye_physiology1.35392166
49MP0003787_abnormal_imprinting1.35177887
50MP0004885_abnormal_endolymph1.34215804
51MP0000049_abnormal_middle_ear1.33765722
52MP0004142_abnormal_muscle_tone1.32018123
53MP0004133_heterotaxia1.31866478
54MP0001188_hyperpigmentation1.31714785
55MP0002938_white_spotting1.21203543
56MP0002909_abnormal_adrenal_gland1.20946472
57MP0004742_abnormal_vestibular_system1.19058025
58* MP0002152_abnormal_brain_morphology1.17764879
59MP0003119_abnormal_digestive_system1.17663648
60MP0001502_abnormal_circadian_rhythm1.16283180
61MP0003136_yellow_coat_color1.12830869
62MP0005645_abnormal_hypothalamus_physiol1.11947352
63MP0002234_abnormal_pharynx_morphology1.09673178
64MP0003633_abnormal_nervous_system1.08926787
65MP0005389_reproductive_system_phenotype1.07168654
66MP0002876_abnormal_thyroid_physiology1.05830330
67MP0001986_abnormal_taste_sensitivity1.04682776
68MP0003631_nervous_system_phenotype1.04067476
69MP0003937_abnormal_limbs/digits/tail_de1.03902913
70MP0003121_genomic_imprinting1.03243134
71MP0004145_abnormal_muscle_electrophysio1.01779736
72MP0000569_abnormal_digit_pigmentation1.01562888
73MP0004043_abnormal_pH_regulation0.98221599
74MP0003646_muscle_fatigue0.98204088
75MP0001485_abnormal_pinna_reflex0.95320740
76MP0000751_myopathy0.95251426
77MP0005174_abnormal_tail_pigmentation0.94848274
78MP0003634_abnormal_glial_cell0.94386546
79MP0003890_abnormal_embryonic-extraembry0.94175767
80MP0005195_abnormal_posterior_eye0.93937702
81MP0005171_absent_coat_pigmentation0.93336098
82MP0002229_neurodegeneration0.93191274
83MP0005409_darkened_coat_color0.92628265
84MP0002752_abnormal_somatic_nervous0.92475665
85MP0003632_abnormal_nervous_system0.92228749
86MP0001963_abnormal_hearing_physiology0.92085201
87MP0004147_increased_porphyrin_level0.91986993
88MP0000920_abnormal_myelination0.91251811
89MP0002653_abnormal_ependyma_morphology0.90508674
90MP0002069_abnormal_eating/drinking_beha0.89463411
91MP0005551_abnormal_eye_electrophysiolog0.89249569
92MP0001177_atelectasis0.87494401
93MP0004085_abnormal_heartbeat0.84658164
94MP0000631_abnormal_neuroendocrine_gland0.84515157
95MP0003283_abnormal_digestive_organ0.84156700
96MP0009250_abnormal_appendicular_skeleto0.83828778
97MP0002837_dystrophic_cardiac_calcinosis0.82975223
98MP0003137_abnormal_impulse_conducting0.81185074
99MP0004130_abnormal_muscle_cell0.80470919
100MP0001919_abnormal_reproductive_system0.79576018
101MP0005535_abnormal_body_temperature0.77614905
102MP0005499_abnormal_olfactory_system0.77567043
103MP0005394_taste/olfaction_phenotype0.77567043
104MP0003195_calcinosis0.76843192
105MP0003938_abnormal_ear_development0.76781005
106MP0002928_abnormal_bile_duct0.76308950
107MP0008872_abnormal_physiological_respon0.76153925
108MP0008874_decreased_physiological_sensi0.76094121
109MP0003861_abnormal_nervous_system0.74671227
110MP0002102_abnormal_ear_morphology0.74640154
111MP0000604_amyloidosis0.74434521
112MP0001293_anophthalmia0.74234322
113MP0000026_abnormal_inner_ear0.72035489
114MP0003690_abnormal_glial_cell0.69361848
115MP0001943_abnormal_respiration0.66238007
116MP0010386_abnormal_urinary_bladder0.65449146
117MP0001299_abnormal_eye_distance/0.65403956
118MP0004215_abnormal_myocardial_fiber0.64665025
119MP0002090_abnormal_vision0.64193999
120MP0002751_abnormal_autonomic_nervous0.59984386
121MP0005623_abnormal_meninges_morphology0.59198413
122MP0001664_abnormal_digestion0.57945439
123MP0004484_altered_response_of0.56853027
124MP0004233_abnormal_muscle_weight0.55578180
125MP0010769_abnormal_survival0.54680734
126MP0003075_altered_response_to0.54593955
127MP0002082_postnatal_lethality0.54336155
128MP0010770_preweaning_lethality0.54336155
129MP0010768_mortality/aging0.51343534
130MP0005187_abnormal_penis_morphology0.51325835

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.70464396
2Myokymia (HP:0002411)6.23453999
3Focal seizures (HP:0007359)6.00619661
4Visual hallucinations (HP:0002367)5.61067652
5Epileptic encephalopathy (HP:0200134)4.76412929
6Absence seizures (HP:0002121)4.67448852
7Atonic seizures (HP:0010819)4.56710356
8Dialeptic seizures (HP:0011146)4.30692263
9Febrile seizures (HP:0002373)4.14761172
10Progressive cerebellar ataxia (HP:0002073)4.10566079
11Hyperventilation (HP:0002883)4.05935022
12Broad-based gait (HP:0002136)3.92689440
13Generalized tonic-clonic seizures (HP:0002069)3.79079565
14Pancreatic cysts (HP:0001737)3.38629788
15Supranuclear gaze palsy (HP:0000605)3.28999107
16Gaze-evoked nystagmus (HP:0000640)3.22103353
17Action tremor (HP:0002345)3.20957719
18Pancreatic fibrosis (HP:0100732)3.20091713
19Excessive salivation (HP:0003781)3.18699998
20Drooling (HP:0002307)3.18699998
21Amblyopia (HP:0000646)3.17580823
22Abnormality of midbrain morphology (HP:0002418)3.12020284
23Molar tooth sign on MRI (HP:0002419)3.12020284
24Cerebral inclusion bodies (HP:0100314)3.10307596
25Neurofibrillary tangles (HP:0002185)3.05324067
26True hermaphroditism (HP:0010459)3.04706662
27Anxiety (HP:0000739)2.93287076
28Nephronophthisis (HP:0000090)2.93114020
29Truncal ataxia (HP:0002078)2.91254163
30Dysmetria (HP:0001310)2.90374427
31Poor eye contact (HP:0000817)2.88153607
32Congenital stationary night blindness (HP:0007642)2.86989371
33Absent speech (HP:0001344)2.81922945
34Dysdiadochokinesis (HP:0002075)2.75502224
35Impaired vibration sensation in the lower limbs (HP:0002166)2.71990718
36Depression (HP:0000716)2.70305145
37Mutism (HP:0002300)2.62072121
38Abnormal eating behavior (HP:0100738)2.61985056
39Progressive inability to walk (HP:0002505)2.59599517
40Pendular nystagmus (HP:0012043)2.58221320
41Epileptiform EEG discharges (HP:0011182)2.57249637
42Ankle clonus (HP:0011448)2.56973277
43Impaired social interactions (HP:0000735)2.56287260
44Abnormal social behavior (HP:0012433)2.56287260
45Fetal akinesia sequence (HP:0001989)2.50439179
46Urinary bladder sphincter dysfunction (HP:0002839)2.49966187
47Type II lissencephaly (HP:0007260)2.49331293
48Spastic gait (HP:0002064)2.48633730
49Hemiparesis (HP:0001269)2.44336073
50Abnormality of the renal medulla (HP:0100957)2.41529819
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.40217838
52Abnormality of alanine metabolism (HP:0010916)2.40217838
53Hyperalaninemia (HP:0003348)2.40217838
54Chronic hepatic failure (HP:0100626)2.39611661
55Medial flaring of the eyebrow (HP:0010747)2.39385923
56Abnormality of the lower motor neuron (HP:0002366)2.38386215
57Diplopia (HP:0000651)2.36145666
58Abnormality of binocular vision (HP:0011514)2.36145666
59EEG with generalized epileptiform discharges (HP:0011198)2.34396981
60Genetic anticipation (HP:0003743)2.33470628
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.33102612
62Scanning speech (HP:0002168)2.32571245
63Abnormality of the corticospinal tract (HP:0002492)2.31496555
64Generalized myoclonic seizures (HP:0002123)2.30916934
65Postural instability (HP:0002172)2.25741701
66Stereotypic behavior (HP:0000733)2.25343132
67Urinary urgency (HP:0000012)2.24284452
68Megalencephaly (HP:0001355)2.24011441
69Inability to walk (HP:0002540)2.22479803
70Limb dystonia (HP:0002451)2.22194126
71Polyphagia (HP:0002591)2.21968259
72Abolished electroretinogram (ERG) (HP:0000550)2.21702060
73Termporal pattern (HP:0011008)2.20441367
74Insidious onset (HP:0003587)2.20441367
75Abnormality of salivation (HP:0100755)2.20090155
76Hypsarrhythmia (HP:0002521)2.19362720
77Blue irides (HP:0000635)2.18634369
78Amyotrophic lateral sclerosis (HP:0007354)2.18412129
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13377227
80Impaired smooth pursuit (HP:0007772)2.12138862
81Optic nerve hypoplasia (HP:0000609)2.10826205
82Abnormality of the renal cortex (HP:0011035)2.10441985
83Attenuation of retinal blood vessels (HP:0007843)2.10309351
84Protruding tongue (HP:0010808)2.09900751
85Torticollis (HP:0000473)2.09096381
86Small hand (HP:0200055)2.08599385
87Intention tremor (HP:0002080)2.07514093
88Abnormality of the middle phalanges of the toes (HP:0010183)2.07018597
89Lissencephaly (HP:0001339)2.06673223
90Bradykinesia (HP:0002067)2.05149722
91Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04836130
92Akinesia (HP:0002304)2.03713638
93Cystic liver disease (HP:0006706)2.02129941
94Pheochromocytoma (HP:0002666)1.99347975
95Short tibia (HP:0005736)1.97428222
96Anencephaly (HP:0002323)1.94888702
97Focal dystonia (HP:0004373)1.94833592
98Delusions (HP:0000746)1.94795985
99Sclerocornea (HP:0000647)1.94402404
100Lower limb muscle weakness (HP:0007340)1.93675824
101Papilledema (HP:0001085)1.93271114
102Thickened helices (HP:0000391)1.92609730
103Congenital primary aphakia (HP:0007707)1.92377614
104Genital tract atresia (HP:0001827)1.91582405
105Congenital, generalized hypertrichosis (HP:0004540)1.90536307
106Decreased central vision (HP:0007663)1.90121548
107Abnormality of ocular smooth pursuit (HP:0000617)1.89940439
108Rapidly progressive (HP:0003678)1.89174787
109Incomplete penetrance (HP:0003829)1.88909425
110Impaired vibratory sensation (HP:0002495)1.88822986
111Furrowed tongue (HP:0000221)1.88398183
112Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87566425
113Hypoplasia of the brainstem (HP:0002365)1.87566425
114Vaginal atresia (HP:0000148)1.87222742
115Psychosis (HP:0000709)1.86611383
116Aplasia/Hypoplasia of the patella (HP:0006498)1.86467762
117Nephrogenic diabetes insipidus (HP:0009806)1.86315647
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85345779
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.85345779
120Morphological abnormality of the pyramidal tract (HP:0002062)1.83830275
121Agitation (HP:0000713)1.83643464
122Bony spicule pigmentary retinopathy (HP:0007737)1.83171395
123Retinal dysplasia (HP:0007973)1.82867830
124Widely spaced teeth (HP:0000687)1.81908290
125Methylmalonic acidemia (HP:0002912)1.81306927
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80539686
127Short 4th metacarpal (HP:0010044)1.80539686
128Patellar aplasia (HP:0006443)1.80407322
129Symphalangism affecting the phalanges of the hand (HP:0009773)1.80172053
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79197998
131Short hallux (HP:0010109)1.79134299
132Peripheral hypomyelination (HP:0007182)1.78764109
133Dyskinesia (HP:0100660)1.77513608
134Congenital sensorineural hearing impairment (HP:0008527)1.77341163
135Inappropriate behavior (HP:0000719)1.77306892
136Status epilepticus (HP:0002133)1.76977715
137Poor suck (HP:0002033)1.75183187
138Gait imbalance (HP:0002141)1.74861665
139Abnormal drinking behavior (HP:0030082)1.74681752
140Polydipsia (HP:0001959)1.74681752
141Septo-optic dysplasia (HP:0100842)1.74573444
142Neuroendocrine neoplasm (HP:0100634)1.74477419
143Specific learning disability (HP:0001328)1.73802992
144Abnormality of the 4th metacarpal (HP:0010012)1.73746977
145Increased corneal curvature (HP:0100692)1.73657901
146Keratoconus (HP:0000563)1.73657901
147Abnormality of the proximal phalanges of the hand (HP:0009834)1.73553727
148Aplasia/Hypoplasia of the hallux (HP:0008362)1.72902135
149Hypoplasia of the ulna (HP:0003022)1.72856105
150Gait ataxia (HP:0002066)1.72376783
151Abnormal rod and cone electroretinograms (HP:0008323)1.71415164
152Aplasia involving bones of the upper limbs (HP:0009823)1.71356335
153Aplasia of the phalanges of the hand (HP:0009802)1.71356335
154Aplasia involving bones of the extremities (HP:0009825)1.71356335
155Oligodactyly (hands) (HP:0001180)1.71329598
156Hemiplegia (HP:0002301)1.71168716
157Neuronal loss in central nervous system (HP:0002529)1.70344844
158Craniofacial dystonia (HP:0012179)1.70006867
159Chorioretinal atrophy (HP:0000533)1.69603805
160Concave nail (HP:0001598)1.67971533
161Pachygyria (HP:0001302)1.66315161
162Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.64754796
163Postaxial foot polydactyly (HP:0001830)1.63648217
164Male pseudohermaphroditism (HP:0000037)1.63376139
165Dynein arm defect of respiratory motile cilia (HP:0012255)1.62623634

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.97065206
2NTRK34.89236352
3FRK3.68661901
4MARK13.26538726
5MAP3K93.23540215
6MAP3K42.63726737
7MINK12.56309343
8PINK12.50440196
9CASK2.48556077
10BMPR1B2.30662417
11MAP2K72.23024039
12ADRBK22.16262108
13NTRK22.11523431
14RIPK42.08125592
15MAP3K122.06589239
16KSR12.05349881
17TLK12.05213160
18PNCK2.03210281
19TNIK2.01168582
20DAPK21.93190794
21PAK61.89976209
22KSR21.88033010
23ZAK1.86781227
24GRK11.82172216
25MAPK131.73705338
26MAP2K41.70539375
27ACVR1B1.70102373
28PLK21.67240910
29MAP4K21.56326148
30NTRK11.53025970
31DYRK21.52803481
32PRPF4B1.51899874
33CDK51.48815482
34WNK41.47823124
35DAPK11.43388898
36MKNK21.39982020
37SIK21.35840529
38ARAF1.31224983
39NUAK11.31018666
40PHKG21.27701906
41PHKG11.27701906
42GRK51.26325384
43PRKD31.25757761
44INSRR1.22295819
45FES1.20504107
46PRKCG1.19556282
47CDK191.18858508
48CAMK2A1.18730083
49MUSK1.17103965
50TRIM281.16640670
51TYRO31.15023523
52CSNK1G11.13055562
53UHMK11.11915586
54CAMKK11.11431420
55CAMK2B1.10766132
56BMPR21.04063669
57MAPKAPK51.02556944
58NME10.99718460
59MAP3K20.99607692
60CDK180.98912302
61OXSR10.98599271
62MAP3K130.97518065
63CDK150.94330571
64CDK140.92546471
65TAOK30.92453717
66CSNK1A1L0.92274142
67PTK2B0.91273053
68CCNB10.91241196
69BCR0.90098832
70TAF10.88832394
71RAF10.88386135
72SIK30.88247088
73CSNK1G20.87461359
74PAK30.84741523
75CDK11A0.81299665
76FGR0.80743242
77LATS20.79990397
78DYRK1A0.79766628
79SGK4940.79369733
80SGK2230.79369733
81STK380.77631341
82CDC70.75158472
83SGK10.74148219
84ADRBK10.73638823
85CAMK10.73375496
86STK110.71510267
87MAPK150.71496417
88MARK20.71143468
89MKNK10.70735852
90FGFR20.66641931
91AKT30.63967019
92STK390.63921577
93VRK10.63802542
94RET0.63777712
95PRKCE0.60426040
96CAMK2D0.60019593
97SGK20.58533157
98STK160.58049937
99CSNK1A10.55457193
100PRKCH0.53036092
101CAMK40.53007498
102STK38L0.50785789
103RPS6KA50.50675948
104NEK20.50652036
105PRKCZ0.50590798
106NEK60.50553571
107CSNK1D0.48185191
108PKN10.47619384
109PDPK10.47345013
110FER0.47320692
111ROCK20.46876875
112CAMK2G0.46875316
113TGFBR10.46287446
114TAOK10.46119994
115CAMKK20.44756216
116FYN0.44628472
117RPS6KA30.44296263
118CDK30.43038527
119PDK10.42704030
120WNK30.42469815
121CAMK1G0.41571262
122WEE10.40614331
123DYRK30.39787681
124MAPK100.39213329
125LMTK20.37775685
126MAP3K70.37645027
127CSNK1G30.37614655
128MAP2K10.36809553
129MAP3K60.36372074
130PLK30.36299902
131GRK70.36138810
132SGK30.34522978
133ERBB20.33839877
134MAP3K10.33605223
135PIK3CA0.33584974
136PRKACA0.33416784
137PRKCA0.33154148
138CHEK20.32915600
139CSNK1E0.32088143
140EPHB20.31587407
141PRKCB0.30994729
142PRKG10.30415239
143BRAF0.29840059
144ERBB30.29611312

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25186057
2Synaptic vesicle cycle_Homo sapiens_hsa047212.94021471
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.85354617
4Long-term potentiation_Homo sapiens_hsa047202.80708437
5Circadian entrainment_Homo sapiens_hsa047132.76568054
6Glutamatergic synapse_Homo sapiens_hsa047242.75405543
7GABAergic synapse_Homo sapiens_hsa047272.73587235
8Amphetamine addiction_Homo sapiens_hsa050312.59416881
9Morphine addiction_Homo sapiens_hsa050322.56774497
10Olfactory transduction_Homo sapiens_hsa047402.51065283
11Dopaminergic synapse_Homo sapiens_hsa047282.22144149
12Salivary secretion_Homo sapiens_hsa049702.18970245
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03027044
14Taste transduction_Homo sapiens_hsa047421.90329697
15Cholinergic synapse_Homo sapiens_hsa047251.88260888
16Gastric acid secretion_Homo sapiens_hsa049711.87105667
17Serotonergic synapse_Homo sapiens_hsa047261.84588335
18Long-term depression_Homo sapiens_hsa047301.83030749
19Insulin secretion_Homo sapiens_hsa049111.81779808
20Cocaine addiction_Homo sapiens_hsa050301.78249202
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74557844
22Renin secretion_Homo sapiens_hsa049241.73209611
23Calcium signaling pathway_Homo sapiens_hsa040201.71863299
24Oxytocin signaling pathway_Homo sapiens_hsa049211.65282988
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61977240
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60533799
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59102238
28Nitrogen metabolism_Homo sapiens_hsa009101.56953234
29Axon guidance_Homo sapiens_hsa043601.56019119
30Collecting duct acid secretion_Homo sapiens_hsa049661.54295484
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50029330
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.47572272
33GnRH signaling pathway_Homo sapiens_hsa049121.44344895
34Gap junction_Homo sapiens_hsa045401.41648687
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35425858
36Linoleic acid metabolism_Homo sapiens_hsa005911.30259434
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28676182
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27997403
39cAMP signaling pathway_Homo sapiens_hsa040241.27752332
40Butanoate metabolism_Homo sapiens_hsa006501.26450544
41Cardiac muscle contraction_Homo sapiens_hsa042601.25746894
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24884454
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21319555
44Basal transcription factors_Homo sapiens_hsa030221.20358562
45Glioma_Homo sapiens_hsa052141.12918286
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12813860
47Protein export_Homo sapiens_hsa030601.11784667
48Melanogenesis_Homo sapiens_hsa049161.11318820
49Estrogen signaling pathway_Homo sapiens_hsa049151.06508373
50Fanconi anemia pathway_Homo sapiens_hsa034601.05905688
51ErbB signaling pathway_Homo sapiens_hsa040121.03946901
52Selenocompound metabolism_Homo sapiens_hsa004501.03480414
53Ether lipid metabolism_Homo sapiens_hsa005650.99388131
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98991814
55Vibrio cholerae infection_Homo sapiens_hsa051100.97877098
56Homologous recombination_Homo sapiens_hsa034400.95800287
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95695445
58RNA polymerase_Homo sapiens_hsa030200.95106877
59Type II diabetes mellitus_Homo sapiens_hsa049300.94899328
60RNA degradation_Homo sapiens_hsa030180.93545461
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91117951
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.90557363
63Alzheimers disease_Homo sapiens_hsa050100.90237110
64Oocyte meiosis_Homo sapiens_hsa041140.86620464
65Tryptophan metabolism_Homo sapiens_hsa003800.85842492
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85073267
67Pancreatic secretion_Homo sapiens_hsa049720.83258437
68Phototransduction_Homo sapiens_hsa047440.82997373
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.81851064
70Choline metabolism in cancer_Homo sapiens_hsa052310.78482854
71Dilated cardiomyopathy_Homo sapiens_hsa054140.77396115
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76721203
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76666164
74Oxidative phosphorylation_Homo sapiens_hsa001900.76389350
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71805957
76Basal cell carcinoma_Homo sapiens_hsa052170.71592838
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71381580
78Dorso-ventral axis formation_Homo sapiens_hsa043200.71049638
79MAPK signaling pathway_Homo sapiens_hsa040100.69926509
80Thyroid hormone synthesis_Homo sapiens_hsa049180.67397291
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64623155
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62836739
83Ras signaling pathway_Homo sapiens_hsa040140.62758893
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.60591712
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60529174
86VEGF signaling pathway_Homo sapiens_hsa043700.60286853
87Chemical carcinogenesis_Homo sapiens_hsa052040.59173641
88Parkinsons disease_Homo sapiens_hsa050120.57840923
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57551530
90Ribosome_Homo sapiens_hsa030100.57543785
91Sulfur relay system_Homo sapiens_hsa041220.57388811
92Rap1 signaling pathway_Homo sapiens_hsa040150.55512418
93Wnt signaling pathway_Homo sapiens_hsa043100.55074710
94Hippo signaling pathway_Homo sapiens_hsa043900.54366335
95Retinol metabolism_Homo sapiens_hsa008300.53244052
96Alcoholism_Homo sapiens_hsa050340.53130541
97Glucagon signaling pathway_Homo sapiens_hsa049220.52384193
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52241874
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52175748
100Caffeine metabolism_Homo sapiens_hsa002320.52128902
101Regulation of autophagy_Homo sapiens_hsa041400.52037735
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.51783362
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50989435
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.49503724
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48288093
106Prion diseases_Homo sapiens_hsa050200.47603386
107Sulfur metabolism_Homo sapiens_hsa009200.45738038
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45603294
109Propanoate metabolism_Homo sapiens_hsa006400.43756288
110African trypanosomiasis_Homo sapiens_hsa051430.43695639
111ABC transporters_Homo sapiens_hsa020100.42126683
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41086108
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40502987
114One carbon pool by folate_Homo sapiens_hsa006700.40306710
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40253323
116Huntingtons disease_Homo sapiens_hsa050160.40128460
117Purine metabolism_Homo sapiens_hsa002300.39843792
118Renal cell carcinoma_Homo sapiens_hsa052110.39838065
119Peroxisome_Homo sapiens_hsa041460.39334292
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38666618
121Glycerolipid metabolism_Homo sapiens_hsa005610.38198887
122Hedgehog signaling pathway_Homo sapiens_hsa043400.37875702
123Ovarian steroidogenesis_Homo sapiens_hsa049130.37783111
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.36826718
125Type I diabetes mellitus_Homo sapiens_hsa049400.35776056
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35118906
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33082808
128Bile secretion_Homo sapiens_hsa049760.32609564
129Fatty acid biosynthesis_Homo sapiens_hsa000610.32375399
130Non-small cell lung cancer_Homo sapiens_hsa052230.32007569
131Endocytosis_Homo sapiens_hsa041440.31758948
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31199801
133Endometrial cancer_Homo sapiens_hsa052130.28914130
134Inositol phosphate metabolism_Homo sapiens_hsa005620.28596842
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28283851
136Circadian rhythm_Homo sapiens_hsa047100.27214216
137mTOR signaling pathway_Homo sapiens_hsa041500.26481027
138Colorectal cancer_Homo sapiens_hsa052100.25080801
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24391610

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