SLMAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)4.91494776
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.81469954
3cardiac myofibril assembly (GO:0055003)4.30115324
4interkinetic nuclear migration (GO:0022027)4.21311402
5negative regulation of potassium ion transmembrane transport (GO:1901380)4.15910540
6regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.11351351
7sarcoplasmic reticulum calcium ion transport (GO:0070296)4.04155800
8plasma membrane repair (GO:0001778)3.99970488
9carnitine shuttle (GO:0006853)3.82300551
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.72687664
11response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.72469765
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.65907541
13positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.65738550
14interleukin-6-mediated signaling pathway (GO:0070102)3.59918348
15response to inactivity (GO:0014854)3.57680376
16fatty acid transmembrane transport (GO:1902001)3.56504622
17striated muscle contraction (GO:0006941)3.56331425
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.56176747
19cardiac muscle hypertrophy (GO:0003300)3.55545378
20establishment of protein localization to Golgi (GO:0072600)3.51804806
21sarcomere organization (GO:0045214)3.48162160
22adult heart development (GO:0007512)3.44914645
23striated muscle hypertrophy (GO:0014897)3.37281962
24myofibril assembly (GO:0030239)3.36607974
25cardiac muscle adaptation (GO:0014887)3.31452413
26cardiac muscle hypertrophy in response to stress (GO:0014898)3.31452413
27muscle hypertrophy in response to stress (GO:0003299)3.31452413
28response to caffeine (GO:0031000)3.31427237
29regulation of cell communication by electrical coupling (GO:0010649)3.31398463
30cardiac muscle tissue morphogenesis (GO:0055008)3.24104024
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.22897769
32heart trabecula formation (GO:0060347)3.22611282
33cell communication involved in cardiac conduction (GO:0086065)3.20847751
34muscle tissue morphogenesis (GO:0060415)3.20502794
35regulation of striated muscle contraction (GO:0006942)3.18094048
36cardiac muscle cell development (GO:0055013)3.16888033
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.16763289
38insulin-like growth factor receptor signaling pathway (GO:0048009)3.13351593
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.13086554
40skeletal muscle adaptation (GO:0043501)3.12374815
41retrograde transport, vesicle recycling within Golgi (GO:0000301)3.12037520
42regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.11761435
43ventricular cardiac muscle cell action potential (GO:0086005)3.09269112
44* muscle contraction (GO:0006936)3.07657781
45cardiac muscle contraction (GO:0060048)3.04778396
46cellular response to epinephrine stimulus (GO:0071872)3.02774689
47cardiac cell development (GO:0055006)3.02532951
48histone-serine phosphorylation (GO:0035404)3.02155591
49regulation of establishment of cell polarity (GO:2000114)3.00377082
50regulation of sarcomere organization (GO:0060297)3.00211700
51nucleus localization (GO:0051647)2.99741842
52histone H3-K4 trimethylation (GO:0080182)2.99127326
53stress fiber assembly (GO:0043149)2.98325886
54regulation of skeletal muscle contraction (GO:0014819)2.98318639
55bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97085583
56relaxation of muscle (GO:0090075)2.97056970
57response to epinephrine (GO:0071871)2.96252976
58cell communication by electrical coupling (GO:0010644)2.94833241
59ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.92970140
60muscle hypertrophy (GO:0014896)2.89741096
61* muscle system process (GO:0003012)2.89491000
62relaxation of cardiac muscle (GO:0055119)2.87486955
63hypotonic response (GO:0006971)2.87009235
64actomyosin structure organization (GO:0031032)2.86836182
65positive regulation of cation channel activity (GO:2001259)2.86617864
66regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.86597774
67coronary vasculature morphogenesis (GO:0060977)2.85650559
68carnitine transmembrane transport (GO:1902603)2.84639218
69cellular response to ethanol (GO:0071361)2.83307464
70negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.82219442
71cytoskeletal anchoring at plasma membrane (GO:0007016)2.79608523
72regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.78779227
73regulation of cardiac muscle contraction (GO:0055117)2.78636109
74cellular response to growth hormone stimulus (GO:0071378)2.77703089
75phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.76951202
76regulation of actin filament-based movement (GO:1903115)2.75560741
77regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.75028227
78pericardium development (GO:0060039)2.74274066
79regulation of transforming growth factor beta2 production (GO:0032909)2.73548781
80positive regulation of fatty acid beta-oxidation (GO:0032000)2.71952883
81regulation of fatty acid beta-oxidation (GO:0031998)2.71785052
82import into cell (GO:0098657)2.71439230
83regulation of fatty acid oxidation (GO:0046320)2.70727538
84amino-acid betaine transport (GO:0015838)2.70447883
85carnitine transport (GO:0015879)2.70447883
86negative regulation of vascular permeability (GO:0043116)2.70398041
87apoptotic cell clearance (GO:0043277)2.69815393
88striated muscle atrophy (GO:0014891)2.69288663
89skeletal muscle contraction (GO:0003009)2.68931436
90intestinal epithelial cell development (GO:0060576)2.67798133
91sodium ion export (GO:0071436)2.66968611
92tricarboxylic acid cycle (GO:0006099)2.66385848
93cardiac conduction (GO:0061337)2.64570222
94regulation of cardioblast differentiation (GO:0051890)2.63299017
95regulation of tight junction assembly (GO:2000810)2.62038828
96lysine catabolic process (GO:0006554)2.61282132
97lysine metabolic process (GO:0006553)2.61282132
98regulation of calcium ion transmembrane transporter activity (GO:1901019)2.61007825
99regulation of calcium ion transmembrane transport (GO:1903169)2.61007825
100cell-substrate junction assembly (GO:0007044)2.60844734
101macroautophagy (GO:0016236)2.60550382
102fibroblast migration (GO:0010761)2.60369826
1032-oxoglutarate metabolic process (GO:0006103)2.59012155
104NLS-bearing protein import into nucleus (GO:0006607)2.58378816
105regulation of establishment or maintenance of cell polarity (GO:0032878)2.58332414
106actin-myosin filament sliding (GO:0033275)2.57413440
107muscle filament sliding (GO:0030049)2.57413440
108regulation of muscle system process (GO:0090257)2.56513067
109monoubiquitinated protein deubiquitination (GO:0035520)2.56405209
110positive regulation of fatty acid oxidation (GO:0046321)2.56049782
111regulation of pigment cell differentiation (GO:0050932)2.55785879
112desmosome organization (GO:0002934)2.55282260
113adherens junction assembly (GO:0034333)2.54836474
114regulation of acyl-CoA biosynthetic process (GO:0050812)2.54204059
115mitotic sister chromatid cohesion (GO:0007064)2.54183396
116regulation of membrane repolarization (GO:0060306)2.54157745
117protein localization to endosome (GO:0036010)2.53719006
118cytoplasmic mRNA processing body assembly (GO:0033962)2.52735485
119negative regulation of myotube differentiation (GO:0010832)2.52649833
120intracellular lipid transport (GO:0032365)2.51725392
121regulation of the force of heart contraction (GO:0002026)2.51673106
122cardiac muscle cell action potential (GO:0086001)2.50969166
123negative regulation of protein localization to cell surface (GO:2000009)2.50264782
124atrial septum morphogenesis (GO:0060413)2.49770301
125epithelial cell-cell adhesion (GO:0090136)2.49173075
126membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.48818769
127regulation of clathrin-mediated endocytosis (GO:2000369)2.47036386
128regulation of sequestering of triglyceride (GO:0010889)2.46296203
129regulation of p38MAPK cascade (GO:1900744)2.45483860
130striated muscle adaptation (GO:0014888)2.44993802
131negative regulation of fatty acid transport (GO:2000192)2.44986264
132cell-substrate adherens junction assembly (GO:0007045)2.44590888
133focal adhesion assembly (GO:0048041)2.44590888
134hemidesmosome assembly (GO:0031581)2.44437549
135cardiac muscle cell action potential involved in contraction (GO:0086002)2.42931841
136growth hormone receptor signaling pathway (GO:0060396)2.41080717
137regulation of heart rate by cardiac conduction (GO:0086091)2.40186733
138positive regulation of heart contraction (GO:0045823)2.39892872
139protein targeting to Golgi (GO:0000042)2.39650972
140regulation of cardiac muscle cell contraction (GO:0086004)2.37277545
141growth hormone secretion (GO:0030252)2.36128788
142establishment of nucleus localization (GO:0040023)2.35824648
143actin-mediated cell contraction (GO:0070252)2.35545169
144actin filament-based movement (GO:0030048)2.34361635
145regulation of cofactor metabolic process (GO:0051193)2.34284372
146regulation of coenzyme metabolic process (GO:0051196)2.34284372
147hippo signaling (GO:0035329)2.32030858
148negative regulation of potassium ion transport (GO:0043267)2.31833768
149dicarboxylic acid biosynthetic process (GO:0043650)2.31593593
150negative regulation of heart growth (GO:0061117)2.30301285
151negative regulation of cardiac muscle tissue growth (GO:0055022)2.30301285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15263018
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.58970873
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53995506
4CLOCK_20551151_ChIP-Seq_293T_Human2.46650514
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.42118406
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.28254663
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22391190
8GBX2_23144817_ChIP-Seq_PC3_Human2.18648281
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.16124993
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.14972190
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13574542
12ZNF263_19887448_ChIP-Seq_K562_Human2.11161647
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.08625822
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05961645
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.01901527
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97623056
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.93491113
18* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92396325
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.88459895
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.86468277
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86264397
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86252960
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84300814
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.82548809
25TBX20_22080862_ChIP-Seq_HEART_Mouse1.82548809
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.81127889
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80160122
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.78439287
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76062112
30VDR_22108803_ChIP-Seq_LS180_Human1.73306131
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.73104093
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72317365
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71673361
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.70913034
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69972711
36TP53_16413492_ChIP-PET_HCT116_Human1.67443434
37SMAD4_21799915_ChIP-Seq_A2780_Human1.66965770
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.66497341
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65457932
40FOXM1_26456572_ChIP-Seq_MCF-7_Human1.65431280
41* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63818894
42* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.58525035
43* STAT3_23295773_ChIP-Seq_U87_Human1.58376126
44* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57719766
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.56188126
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53718420
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53463752
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.53342077
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.52497766
50* TAF15_26573619_Chip-Seq_HEK293_Human1.50919187
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49640916
52* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48979642
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48963700
54GATA1_22025678_ChIP-Seq_K562_Human1.48648050
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47861153
56* TCF4_23295773_ChIP-Seq_U87_Human1.46369686
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43106795
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40882621
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40462431
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36834731
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36299432
62CDX2_22108803_ChIP-Seq_LS180_Human1.35847307
63Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35696865
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35667537
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35634805
66AHR_22903824_ChIP-Seq_MCF-7_Human1.35366969
67KDM2B_26808549_Chip-Seq_K562_Human1.35205750
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33596902
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32442125
70* TP63_23658742_ChIP-Seq_EP156T_Human1.31870759
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31752172
72* CJUN_26792858_Chip-Seq_BT549_Human1.31622840
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.31406535
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30969182
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.30363930
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30362157
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30042665
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28398667
79ER_23166858_ChIP-Seq_MCF-7_Human1.28328091
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28059612
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27406943
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.27283502
83DROSHA_22980978_ChIP-Seq_HELA_Human1.26953974
84KDM2B_26808549_Chip-Seq_DND41_Human1.26785783
85* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26136521
86* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25696140
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25311688
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.24547902
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24521157
90ISL1_27105846_Chip-Seq_CPCs_Mouse1.22986106
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22858147
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.22727041
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22588283
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22394120
95FUS_26573619_Chip-Seq_HEK293_Human1.21908172
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20883779
97P300_19829295_ChIP-Seq_ESCs_Human1.19536981
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19054587
99RARB_27405468_Chip-Seq_BRAIN_Mouse1.18948281
100* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18720752
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17107508
102AR_21572438_ChIP-Seq_LNCaP_Human1.17046523
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15500250
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15145805
105HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15126232
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.15107205
107BRD4_25478319_ChIP-Seq_HGPS_Human1.13083851
108* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12914599
109* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12645401
110* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12645401
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.11664501
112* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10939158
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10841196
114* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10474088
115* TCF7_22412390_ChIP-Seq_EML_Mouse1.10059019
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09942900
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07359894
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.06687265
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.06290400
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05261540
121RACK7_27058665_Chip-Seq_MCF-7_Human1.04630589
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.04335755
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03947044
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03903244
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03796491
126IGF1R_20145208_ChIP-Seq_DFB_Human1.03237471
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.03205054
128ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03195076
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03007612
130RXR_22108803_ChIP-Seq_LS180_Human1.02960276
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02906304
132ATF3_27146783_Chip-Seq_COLON_Human1.02612869
133* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02109275
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02050078
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01659352
136FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01659306
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01074381
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99993492
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99993492
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99625075
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.99466352
142SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99383954
143* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98889937
144MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98453199
145FLI1_21867929_ChIP-Seq_TH2_Mouse0.98038965
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97957874
147TBL1_22424771_ChIP-Seq_293T_Human0.97735879
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97351274
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97327420
150P53_22387025_ChIP-Seq_ESCs_Mouse0.97156022
151AR_25329375_ChIP-Seq_VCAP_Human0.96901046
152SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96618535
153FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96584358
154CRX_20693478_ChIP-Seq_RETINA_Mouse0.96359370
155EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93825891
156* BCAT_22108803_ChIP-Seq_LS180_Human0.92767355
157CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92638840
158TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91339455
159AR_19668381_ChIP-Seq_PC3_Human0.91269614
160ELK3_25401928_ChIP-Seq_HUVEC_Human0.90906216
161TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89641773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle3.64540478
2MP0003705_abnormal_hypodermis_morpholog3.53472896
3MP0008057_abnormal_DNA_replication3.45792155
4MP0002837_dystrophic_cardiac_calcinosis3.21017870
5MP0000751_myopathy2.94504618
6MP0004215_abnormal_myocardial_fiber2.78777326
7MP0005330_cardiomyopathy2.67956412
8MP0004036_abnormal_muscle_relaxation2.58959511
9MP0004130_abnormal_muscle_cell2.53666088
10MP0010234_abnormal_vibrissa_follicle2.53500524
11MP0009384_cardiac_valve_regurgitation2.47494812
12MP0004087_abnormal_muscle_fiber2.29795140
13MP0006138_congestive_heart_failure2.28410786
14MP0003300_gastrointestinal_ulcer2.14819338
15MP0010630_abnormal_cardiac_muscle2.13599152
16MP0004272_abnormal_basement_membrane2.11006155
17MP0008438_abnormal_cutaneous_collagen2.04906423
18MP0002972_abnormal_cardiac_muscle2.01291951
19MP0010352_gastrointestinal_tract_polyps1.97901937
20MP0003646_muscle_fatigue1.96912151
21MP0005620_abnormal_muscle_contractility1.96371699
22MP0009780_abnormal_chondrocyte_physiolo1.96366959
23MP0003045_fibrosis1.95383568
24MP0005623_abnormal_meninges_morphology1.93310850
25MP0000383_abnormal_hair_follicle1.92732066
26MP0004185_abnormal_adipocyte_glucose1.91200039
27MP0003566_abnormal_cell_adhesion1.90924453
28MP0005666_abnormal_adipose_tissue1.89825532
29MP0001544_abnormal_cardiovascular_syste1.88538505
30MP0005385_cardiovascular_system_phenoty1.88538505
31MP0004484_altered_response_of1.88011369
32MP0008775_abnormal_heart_ventricle1.83428371
33MP0005275_abnormal_skin_tensile1.81258055
34MP0000749_muscle_degeneration1.77782733
35MP0003828_pulmonary_edema1.75561903
36MP0008961_abnormal_basal_metabolism1.63762918
37MP0002877_abnormal_melanocyte_morpholog1.60224249
38MP0005085_abnormal_gallbladder_physiolo1.58290923
39MP0002332_abnormal_exercise_endurance1.56016899
40MP0010368_abnormal_lymphatic_system1.54234358
41MP0000747_muscle_weakness1.53632646
42MP0000750_abnormal_muscle_regeneration1.52116509
43MP0002269_muscular_atrophy1.51614936
44MP0004085_abnormal_heartbeat1.51358946
45MP0003252_abnormal_bile_duct1.48906397
46MP0005076_abnormal_cell_differentiation1.47484220
47MP0001958_emphysema1.41799457
48MP0005375_adipose_tissue_phenotype1.41778134
49MP0003279_aneurysm1.41423584
50MP0008004_abnormal_stomach_pH1.40175957
51MP0005670_abnormal_white_adipose1.39580012
52MP0000569_abnormal_digit_pigmentation1.39387394
53MP0002106_abnormal_muscle_physiology1.27387713
54MP0000013_abnormal_adipose_tissue1.26254285
55MP0004233_abnormal_muscle_weight1.25186358
56MP0003137_abnormal_impulse_conducting1.19042116
57MP0002127_abnormal_cardiovascular_syste1.18083832
58MP0000427_abnormal_hair_cycle1.15198526
59MP0000003_abnormal_adipose_tissue1.14379924
60MP0002822_catalepsy1.12704539
61MP0005360_urolithiasis1.12448221
62MP0003091_abnormal_cell_migration1.08034963
63MP0001879_abnormal_lymphatic_vessel1.07422746
64MP0005369_muscle_phenotype1.07229157
65MP0000266_abnormal_heart_morphology1.07199943
66MP0000759_abnormal_skeletal_muscle1.07030177
67MP0003221_abnormal_cardiomyocyte_apopto1.06055468
68MP0000767_abnormal_smooth_muscle1.05487920
69MP0004145_abnormal_muscle_electrophysio1.04821942
70MP0004510_myositis1.03901487
71MP0002009_preneoplasia1.03051982
72MP0000733_abnormal_muscle_development0.98748793
73MP0002108_abnormal_muscle_morphology0.98674872
74MP0003950_abnormal_plasma_membrane0.96045503
75MP0005167_abnormal_blood-brain_barrier0.94739802
76MP0001881_abnormal_mammary_gland0.94581702
77MP0002128_abnormal_blood_circulation0.94384145
78MP0005503_abnormal_tendon_morphology0.93613538
79MP0006054_spinal_hemorrhage0.93140301
80MP0010329_abnormal_lipoprotein_level0.93031347
81MP0003941_abnormal_skin_development0.92330296
82MP0002896_abnormal_bone_mineralization0.90230233
83MP0004859_abnormal_synaptic_plasticity0.90116567
84MP0004264_abnormal_extraembryonic_tissu0.90115080
85MP0003567_abnormal_fetal_cardiomyocyte0.89768693
86MP0005187_abnormal_penis_morphology0.87426614
87MP0005365_abnormal_bile_salt0.86930149
88MP0002909_abnormal_adrenal_gland0.85822084
89MP0005409_darkened_coat_color0.85616448
90MP0002168_other_aberrant_phenotype0.85437605
91MP0005023_abnormal_wound_healing0.85386322
92MP0002925_abnormal_cardiovascular_devel0.85079024
93MP0002971_abnormal_brown_adipose0.85013444
94MP0010678_abnormal_skin_adnexa0.83303435
95MP0002060_abnormal_skin_morphology0.83115951
96MP0002254_reproductive_system_inflammat0.82775517
97MP0002166_altered_tumor_susceptibility0.82588409
98MP0005266_abnormal_metabolism0.80653739
99MP0003890_abnormal_embryonic-extraembry0.76814665
100MP0001661_extended_life_span0.76557792
101MP0003984_embryonic_growth_retardation0.73175387
102MP0003453_abnormal_keratinocyte_physiol0.72982993
103MP0005464_abnormal_platelet_physiology0.72873125
104MP0002088_abnormal_embryonic_growth/wei0.72247710
105MP0000579_abnormal_nail_morphology0.72129069
106MP0002139_abnormal_hepatobiliary_system0.71380297
107MP0004134_abnormal_chest_morphology0.69891077
108MP0000230_abnormal_systemic_arterial0.68537166
109MP0002295_abnormal_pulmonary_circulatio0.65819552
110MP0001614_abnormal_blood_vessel0.65409136
111MP0001784_abnormal_fluid_regulation0.64890515
112MP0002086_abnormal_extraembryonic_tissu0.64273089
113MP0003303_peritoneal_inflammation0.64161771
114MP0003115_abnormal_respiratory_system0.62827713
115MP0005165_increased_susceptibility_to0.62500637
116MP0005083_abnormal_biliary_tract0.59605643
117MP0000428_abnormal_craniofacial_morphol0.59385511
118MP0003943_abnormal_hepatobiliary_system0.58721632
119MP0001851_eye_inflammation0.57772757
120MP0009697_abnormal_copulation0.56898050
121MP0004808_abnormal_hematopoietic_stem0.55693256
122MP0000470_abnormal_stomach_morphology0.55232270
123MP0004043_abnormal_pH_regulation0.53586281
124MP0008877_abnormal_DNA_methylation0.52862941
125MP0000762_abnormal_tongue_morphology0.50250837

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.54871821
2Muscle fiber inclusion bodies (HP:0100299)5.54226399
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.54096390
4Right ventricular cardiomyopathy (HP:0011663)4.73539817
5Sudden death (HP:0001699)4.70358111
6Aortic aneurysm (HP:0004942)3.92379143
7Hyporeflexia of lower limbs (HP:0002600)3.80084966
8Cerebral aneurysm (HP:0004944)3.61933098
9Ventricular tachycardia (HP:0004756)3.51299985
10Increased connective tissue (HP:0009025)3.48365305
11Atrial fibrillation (HP:0005110)3.36962355
12Subaortic stenosis (HP:0001682)3.36086477
13Abnormality of the left ventricular outflow tract (HP:0011103)3.36086477
14Muscle fiber splitting (HP:0003555)3.18171144
15Calf muscle hypertrophy (HP:0008981)3.17479874
16Dysmetric saccades (HP:0000641)3.15252341
17Bundle branch block (HP:0011710)3.14215696
18Primary atrial arrhythmia (HP:0001692)3.13293271
19Syncope (HP:0001279)3.13062641
20Exercise-induced muscle cramps (HP:0003710)3.08852276
21Areflexia of lower limbs (HP:0002522)3.06949326
22Abnormality of the calf musculature (HP:0001430)3.06226103
23Hyperkalemia (HP:0002153)3.03444365
24Supraventricular arrhythmia (HP:0005115)2.94199877
25Aneurysm (HP:0002617)2.92570827
26Supraventricular tachycardia (HP:0004755)2.90516939
27Aortic dissection (HP:0002647)2.90398609
28Exercise-induced myalgia (HP:0003738)2.84698295
29Protrusio acetabuli (HP:0003179)2.84517459
30Ventricular arrhythmia (HP:0004308)2.82775068
31Papillary thyroid carcinoma (HP:0002895)2.82313068
32Ankle contracture (HP:0006466)2.80888978
33Lipoatrophy (HP:0100578)2.74817593
34Atrioventricular block (HP:0001678)2.74083951
35Rectal prolapse (HP:0002035)2.73793821
36EMG: neuropathic changes (HP:0003445)2.72641158
37Neck muscle weakness (HP:0000467)2.72315084
38Type 1 muscle fiber predominance (HP:0003803)2.70193616
39Muscle hypertrophy of the lower extremities (HP:0008968)2.64011539
40Facial diplegia (HP:0001349)2.63368177
41Rimmed vacuoles (HP:0003805)2.59943606
42Prolonged QT interval (HP:0001657)2.57776174
43Ventricular fibrillation (HP:0001663)2.56325180
44Difficulty running (HP:0009046)2.53886215
45Distal lower limb muscle weakness (HP:0009053)2.48755271
46Hypoplastic ischia (HP:0003175)2.47665339
47Lymphangioma (HP:0100764)2.46433883
48Broad metatarsal (HP:0001783)2.46286273
49Heart block (HP:0012722)2.45048556
50Distal arthrogryposis (HP:0005684)2.43326484
51Abnormal atrioventricular conduction (HP:0005150)2.41995662
52Myoglobinuria (HP:0002913)2.40057647
53Mitral valve prolapse (HP:0001634)2.39965808
54Lip pit (HP:0100267)2.38069090
55Difficulty climbing stairs (HP:0003551)2.34132602
56Resting tremor (HP:0002322)2.29728130
57Scapular winging (HP:0003691)2.28732549
58Distal upper limb amyotrophy (HP:0007149)2.28346995
59Upper limb amyotrophy (HP:0009129)2.28346995
60Fair hair (HP:0002286)2.26265534
61Abnormality of the ischium (HP:0003174)2.24389463
62Macroorchidism (HP:0000053)2.22665801
63Mildly elevated creatine phosphokinase (HP:0008180)2.22650107
64Increased variability in muscle fiber diameter (HP:0003557)2.19195761
65EMG: myopathic abnormalities (HP:0003458)2.18493632
66Dilated cardiomyopathy (HP:0001644)2.15591682
67Centrally nucleated skeletal muscle fibers (HP:0003687)2.15408264
68Dilatation of the ascending aorta (HP:0005111)2.15066249
69Asymmetric septal hypertrophy (HP:0001670)2.14058165
70Acute myeloid leukemia (HP:0004808)2.12421597
71Premature rupture of membranes (HP:0001788)2.11659173
72Muscular dystrophy (HP:0003560)2.10832724
73Atrophic scars (HP:0001075)2.08688795
74Central scotoma (HP:0000603)2.06611209
75Shallow orbits (HP:0000586)2.06605792
76Distal lower limb amyotrophy (HP:0008944)2.05467899
77Enlarged penis (HP:0000040)2.02573851
78Hypoplastic labia majora (HP:0000059)2.00428167
79Biliary tract neoplasm (HP:0100574)1.99705226
80Hematochezia (HP:0002573)1.99601636
81Subacute progressive viral hepatitis (HP:0006572)1.99089293
82Round ear (HP:0100830)1.98673358
83Truncal obesity (HP:0001956)1.94417760
84Vertebral arch anomaly (HP:0008438)1.92959834
85Osteolytic defects of the hand bones (HP:0009699)1.92871437
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.92871437
87Abnormality of the labia majora (HP:0012881)1.92547452
88Spinal rigidity (HP:0003306)1.91969392
89Increased mean platelet volume (HP:0011877)1.91830365
90Genetic anticipation (HP:0003743)1.90985857
91Abnormality of skeletal muscle fiber size (HP:0012084)1.88136156
92Palpitations (HP:0001962)1.86338496
93Short chin (HP:0000331)1.85621759
94Lower limb amyotrophy (HP:0007210)1.85589505
95Palmoplantar keratoderma (HP:0000982)1.83766083
96Urethral obstruction (HP:0000796)1.82599364
97Curly hair (HP:0002212)1.80090271
98Hypoalphalipoproteinemia (HP:0003233)1.79217740
99Focal segmental glomerulosclerosis (HP:0000097)1.77608138
100Overgrowth (HP:0001548)1.75169926
101Limb-girdle muscle atrophy (HP:0003797)1.74901851
102Frequent falls (HP:0002359)1.73068498
103Papilledema (HP:0001085)1.72682882
104Abnormal EKG (HP:0003115)1.72011366
105Achilles tendon contracture (HP:0001771)1.71996927
106Hypoglycemic coma (HP:0001325)1.71936129
107Hyperglycemia (HP:0003074)1.71465500
108Hamartoma of the eye (HP:0010568)1.71175284
109Hand muscle atrophy (HP:0009130)1.71132163
110Sudden cardiac death (HP:0001645)1.70783851
111Abnormality of the Achilles tendon (HP:0005109)1.70354018
112Action tremor (HP:0002345)1.69213154
113Abnormal biliary tract morphology (HP:0012440)1.69080184
114Abnormality of the fingertips (HP:0001211)1.68614161
115Myotonia (HP:0002486)1.67584352
116Spinal cord lesions (HP:0100561)1.65941837
117Syringomyelia (HP:0003396)1.65941837
118Proximal amyotrophy (HP:0007126)1.64316451
119Cystic hygroma (HP:0000476)1.64258677
120Rhabdomyolysis (HP:0003201)1.63928705
121Generalized hypopigmentation of hair (HP:0011358)1.63638945
122Long toe (HP:0010511)1.62764054
123Striae distensae (HP:0001065)1.62192213
124Polycythemia (HP:0001901)1.61803820
125Male infertility (HP:0003251)1.61365767
126Hemorrhage of the eye (HP:0011885)1.61244653
127Ketoacidosis (HP:0001993)1.61205007
128Neonatal hypoglycemia (HP:0001998)1.60565424
129Vascular tortuosity (HP:0004948)1.58788081
130Bladder diverticulum (HP:0000015)1.58528144
131Volvulus (HP:0002580)1.58470915
132Left ventricular hypertrophy (HP:0001712)1.57698973
133Abnormal platelet volume (HP:0011876)1.56703410
134Deep venous thrombosis (HP:0002625)1.55762175
135Hip contracture (HP:0003273)1.55116596
136Alopecia of scalp (HP:0002293)1.54989143
137Narrow palate (HP:0000189)1.54916729
138Bicuspid aortic valve (HP:0001647)1.53269346
139Abnormal finger flexion creases (HP:0006143)1.53075524
140Limited hip movement (HP:0008800)1.52060400
141Menorrhagia (HP:0000132)1.51847383
142Long clavicles (HP:0000890)1.50824749
143Steppage gait (HP:0003376)1.50296819
144Ulnar deviation of the wrist (HP:0003049)1.47078604
145Neoplasm of the heart (HP:0100544)1.45698321
146Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.45275065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.96611774
2PIK3CG3.42506221
3TTN3.35188910
4PKN23.14097871
5DMPK3.10175284
6LATS12.75513869
7RIPK12.75083622
8MYLK2.64893225
9LMTK22.26885581
10PDK32.10675971
11PDK42.10675971
12CDK122.03891743
13PDGFRA1.86500703
14ACVR1B1.84512539
15CAMK1D1.82640572
16BRSK21.82245659
17PNCK1.72104167
18FRK1.67997532
19CAMK1G1.60935643
20SIK11.53115912
21PDK21.51866049
22MST1R1.51731227
23PTK61.50919905
24PRKD31.49826436
25EPHA41.47152725
26NLK1.44806535
27OBSCN1.43916117
28MST41.43344612
29PIK3CA1.42361159
30NEK11.33388670
31STK381.32380530
32PAK21.24930048
33MAP3K71.16286555
34STK31.16211248
35STK391.14580008
36SGK31.13722939
37PAK31.11237525
38DDR21.10750219
39ICK1.09202772
40TAOK11.08584023
41MAP3K21.07557199
42WNK11.04114224
43CAMKK21.02935106
44RET1.02486072
45STK38L1.02405345
46PDGFRB1.02290670
47TGFBR21.01713004
48MAP3K41.00638346
49MELK0.98937693
50CDC42BPA0.98767550
51TAF10.97541080
52LATS20.97020229
53CDK60.95419845
54DAPK20.94683625
55CAMKK10.94181800
56KSR20.93431658
57TYRO30.93085773
58STK240.92147897
59BMX0.92100992
60PTK2B0.90570808
61MTOR0.90339282
62TEC0.89109040
63EPHA30.88805472
64FGFR30.88490738
65EEF2K0.87714326
66PRKD10.85423042
67BMPR1B0.84178110
68NUAK10.82716496
69PDPK10.81954794
70PHKG20.81280615
71PHKG10.81280615
72LRRK20.80345832
73MAPKAPK30.79683803
74MAP3K90.77815839
75FER0.76656584
76PDK10.76311292
77ERN10.75736533
78WNK40.74846680
79CASK0.73555445
80PRKAA20.72293397
81ALK0.72204870
82SGK20.72126127
83MAP2K40.70369640
84PTK20.69808958
85TNIK0.68223616
86IRAK10.67883215
87BRD40.67214204
88PRKAA10.65640664
89OXSR10.65224176
90ROCK10.63717482
91FGFR10.62683335
92NEK90.62331276
93JAK10.61955606
94PRKCH0.59835765
95SGK4940.58830252
96SGK2230.58830252
97MKNK20.58519574
98TRPM70.58343357
99CAMK40.57029216
100MAP3K30.55867010
101MAP3K100.55640221
102INSRR0.54160406
103SGK10.52837997
104PAK60.52496446
105STK110.51864115
106FGFR20.51545884
107ERBB30.50923524
108PINK10.50682051
109MAP3K130.50608189
110CAMK10.49850675
111AKT30.49455959
112ILK0.49220475
113EPHA20.48312410
114STK40.47397566
115RPS6KB10.46581949
116MAPK110.46378722
117CAMK2D0.45420905
118RIPK40.45381448
119PRKCE0.44233794
120MAPK70.42547069
121MAP3K50.42059913
122MAP2K10.41905222
123EGFR0.41425549
124CDK40.41283579
125MAP3K60.41214038
126ADRBK10.40624290
127NTRK10.40212658
128SCYL20.39932955
129DAPK30.39546362
130RPS6KB20.38209945
131MET0.37940199
132MAPK120.37680285
133GSK3A0.36708444
134RPS6KA20.36675575
135FLT30.33800415
136MARK10.33304065
137PRKG10.32060083
138MAP3K140.29961612
139RPS6KA60.24715314
140RPS6KA30.23684217
141MARK20.23535547
142MAPK100.22036111
143CAMK2A0.21249795

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.30946249
2Circadian rhythm_Homo sapiens_hsa047102.52266437
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34916364
4Dilated cardiomyopathy_Homo sapiens_hsa054142.24537157
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13961025
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.03724109
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91446075
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.81442026
9Fatty acid degradation_Homo sapiens_hsa000711.67460525
10Fatty acid biosynthesis_Homo sapiens_hsa000611.63851246
11Propanoate metabolism_Homo sapiens_hsa006401.50963602
12Focal adhesion_Homo sapiens_hsa045101.48438658
13Fatty acid metabolism_Homo sapiens_hsa012121.43100768
14ECM-receptor interaction_Homo sapiens_hsa045121.42088284
15Arginine biosynthesis_Homo sapiens_hsa002201.41874215
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39525319
17Adherens junction_Homo sapiens_hsa045201.39012430
18Insulin resistance_Homo sapiens_hsa049311.38204188
19PPAR signaling pathway_Homo sapiens_hsa033201.35587757
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32101971
21Dorso-ventral axis formation_Homo sapiens_hsa043201.31706825
22cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31528177
23Renin secretion_Homo sapiens_hsa049241.29183997
24mTOR signaling pathway_Homo sapiens_hsa041501.28926802
25Amoebiasis_Homo sapiens_hsa051461.18665752
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18260325
27Lysine degradation_Homo sapiens_hsa003101.16922701
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16757179
29Gastric acid secretion_Homo sapiens_hsa049711.11425084
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.11322894
31Proteoglycans in cancer_Homo sapiens_hsa052051.10044534
32Prostate cancer_Homo sapiens_hsa052151.08018347
33Glucagon signaling pathway_Homo sapiens_hsa049221.06739656
34Oxytocin signaling pathway_Homo sapiens_hsa049211.06582616
35Pancreatic secretion_Homo sapiens_hsa049721.06298877
36Bile secretion_Homo sapiens_hsa049761.05704463
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01798308
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.00643288
39Small cell lung cancer_Homo sapiens_hsa052221.00475251
40Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99411915
41Type II diabetes mellitus_Homo sapiens_hsa049300.99368486
42Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98733434
43cAMP signaling pathway_Homo sapiens_hsa040240.97129324
44Carbon metabolism_Homo sapiens_hsa012000.97056924
45Insulin signaling pathway_Homo sapiens_hsa049100.96624813
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96491985
47Glioma_Homo sapiens_hsa052140.95803501
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94117429
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93492229
50Long-term potentiation_Homo sapiens_hsa047200.92987798
51AMPK signaling pathway_Homo sapiens_hsa041520.92521816
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91986767
53ABC transporters_Homo sapiens_hsa020100.91476770
54Viral myocarditis_Homo sapiens_hsa054160.90750197
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88191054
56Thyroid cancer_Homo sapiens_hsa052160.88175095
57Salivary secretion_Homo sapiens_hsa049700.86210492
58Caffeine metabolism_Homo sapiens_hsa002320.84828113
59Inositol phosphate metabolism_Homo sapiens_hsa005620.84444566
60Long-term depression_Homo sapiens_hsa047300.82724159
61Choline metabolism in cancer_Homo sapiens_hsa052310.82124401
62Tight junction_Homo sapiens_hsa045300.81985948
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.81017075
64Pyruvate metabolism_Homo sapiens_hsa006200.80472612
65Ovarian steroidogenesis_Homo sapiens_hsa049130.80384954
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80051491
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79050554
68Estrogen signaling pathway_Homo sapiens_hsa049150.78759232
69Platelet activation_Homo sapiens_hsa046110.78669077
70Cardiac muscle contraction_Homo sapiens_hsa042600.78608044
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78442524
72Starch and sucrose metabolism_Homo sapiens_hsa005000.78346034
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77148314
74Chronic myeloid leukemia_Homo sapiens_hsa052200.75723137
75Linoleic acid metabolism_Homo sapiens_hsa005910.75073265
76Melanoma_Homo sapiens_hsa052180.71894284
77GnRH signaling pathway_Homo sapiens_hsa049120.71432220
78Prolactin signaling pathway_Homo sapiens_hsa049170.71398977
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.69908893
80Olfactory transduction_Homo sapiens_hsa047400.68533589
81Renal cell carcinoma_Homo sapiens_hsa052110.68147708
82Calcium signaling pathway_Homo sapiens_hsa040200.67593138
83Amphetamine addiction_Homo sapiens_hsa050310.67184968
84Protein digestion and absorption_Homo sapiens_hsa049740.66240703
85Endometrial cancer_Homo sapiens_hsa052130.65932411
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65349001
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65080130
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64562603
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64499852
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63911535
91HIF-1 signaling pathway_Homo sapiens_hsa040660.63697138
92Tryptophan metabolism_Homo sapiens_hsa003800.63644541
93Non-small cell lung cancer_Homo sapiens_hsa052230.62602521
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.62570629
95Butanoate metabolism_Homo sapiens_hsa006500.62031121
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61178536
97Circadian entrainment_Homo sapiens_hsa047130.60411551
98MAPK signaling pathway_Homo sapiens_hsa040100.60296748
99Rap1 signaling pathway_Homo sapiens_hsa040150.60205824
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58500472
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58394490
102VEGF signaling pathway_Homo sapiens_hsa043700.57704086
103Colorectal cancer_Homo sapiens_hsa052100.57118816
104TGF-beta signaling pathway_Homo sapiens_hsa043500.56645232
105Toxoplasmosis_Homo sapiens_hsa051450.56439996
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55911762
107Gap junction_Homo sapiens_hsa045400.55203526
108Insulin secretion_Homo sapiens_hsa049110.55096883
109FoxO signaling pathway_Homo sapiens_hsa040680.54859080
110Thyroid hormone synthesis_Homo sapiens_hsa049180.54641292
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.54178897
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.53451877
113Cholinergic synapse_Homo sapiens_hsa047250.52706234
114Serotonergic synapse_Homo sapiens_hsa047260.52525157
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52258011
116Pancreatic cancer_Homo sapiens_hsa052120.51819140
117Pathways in cancer_Homo sapiens_hsa052000.51699475
118MicroRNAs in cancer_Homo sapiens_hsa052060.50837900
119beta-Alanine metabolism_Homo sapiens_hsa004100.50611539
120Hippo signaling pathway_Homo sapiens_hsa043900.50189633
121ErbB signaling pathway_Homo sapiens_hsa040120.49770217
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48933100
123T cell receptor signaling pathway_Homo sapiens_hsa046600.48043625
124B cell receptor signaling pathway_Homo sapiens_hsa046620.47980075
125Dopaminergic synapse_Homo sapiens_hsa047280.46087093
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.45855707
127Bladder cancer_Homo sapiens_hsa052190.45418236
128Hepatitis C_Homo sapiens_hsa051600.44105795
129Acute myeloid leukemia_Homo sapiens_hsa052210.42911855

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