

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitotic sister chromatid cohesion (GO:0007064) | 4.88310366 |
| 2 | chromatin remodeling at centromere (GO:0031055) | 4.67157701 |
| 3 | CENP-A containing nucleosome assembly (GO:0034080) | 4.65103731 |
| 4 | regulation of DNA endoreduplication (GO:0032875) | 4.43958841 |
| 5 | nuclear pore complex assembly (GO:0051292) | 4.06808594 |
| 6 | nuclear pore organization (GO:0006999) | 3.89868891 |
| 7 | pre-miRNA processing (GO:0031054) | 3.77159106 |
| 8 | establishment of integrated proviral latency (GO:0075713) | 3.69902538 |
| 9 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.65762697 |
| 10 | negative regulation of mRNA metabolic process (GO:1903312) | 3.57646726 |
| 11 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.52934019 |
| 12 | negative regulation of sister chromatid segregation (GO:0033046) | 3.52934019 |
| 13 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.52934019 |
| 14 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.52934019 |
| 15 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.52934019 |
| 16 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.47944728 |
| 17 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.47944728 |
| 18 | negative regulation of chromosome segregation (GO:0051985) | 3.44562997 |
| 19 | mitotic G2/M transition checkpoint (GO:0044818) | 3.41557967 |
| 20 | regulation of helicase activity (GO:0051095) | 3.39404156 |
| 21 | regulation of sister chromatid segregation (GO:0033045) | 3.38744596 |
| 22 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.38744596 |
| 23 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.38744596 |
| 24 | histone H3-K9 methylation (GO:0051567) | 3.37716483 |
| 25 | ribosome assembly (GO:0042255) | 3.33950910 |
| 26 | regulation of histone H3-K9 methylation (GO:0051570) | 3.28760961 |
| 27 | non-recombinational repair (GO:0000726) | 3.28287937 |
| 28 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.28287937 |
| 29 | mitotic spindle checkpoint (GO:0071174) | 3.27025569 |
| 30 | mRNA splice site selection (GO:0006376) | 3.25452705 |
| 31 | spindle checkpoint (GO:0031577) | 3.25245781 |
| 32 | histone H3-K4 trimethylation (GO:0080182) | 3.23182985 |
| 33 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.23080563 |
| 34 | DNA double-strand break processing (GO:0000729) | 3.22169581 |
| 35 | mitotic spindle assembly checkpoint (GO:0007094) | 3.21448931 |
| 36 | spindle assembly checkpoint (GO:0071173) | 3.16027231 |
| 37 | DNA replication checkpoint (GO:0000076) | 3.15286540 |
| 38 | kinetochore organization (GO:0051383) | 3.14754704 |
| 39 | mitotic recombination (GO:0006312) | 3.14469265 |
| 40 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.14341227 |
| 41 | pore complex assembly (GO:0046931) | 3.13576612 |
| 42 | telomere maintenance via telomerase (GO:0007004) | 3.13198796 |
| 43 | regulation of chromosome segregation (GO:0051983) | 3.11079803 |
| 44 | telomere maintenance via recombination (GO:0000722) | 3.10377945 |
| 45 | negative regulation of histone methylation (GO:0031061) | 3.09007160 |
| 46 | peptidyl-lysine trimethylation (GO:0018023) | 3.08996684 |
| 47 | regulation of centrosome cycle (GO:0046605) | 3.06844531 |
| 48 | regulation of centrosome duplication (GO:0010824) | 3.06593356 |
| 49 | sister chromatid cohesion (GO:0007062) | 3.06234261 |
| 50 | DNA ligation (GO:0006266) | 3.05576628 |
| 51 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.05168879 |
| 52 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.05168879 |
| 53 | cilium or flagellum-dependent cell motility (GO:0001539) | 3.04997417 |
| 54 | establishment of chromosome localization (GO:0051303) | 3.04240040 |
| 55 | chromatin assembly or disassembly (GO:0006333) | 3.03289198 |
| 56 | transcription from mitochondrial promoter (GO:0006390) | 3.02623212 |
| 57 | positive regulation of chromosome segregation (GO:0051984) | 3.01414652 |
| 58 | mitotic sister chromatid segregation (GO:0000070) | 2.99426117 |
| 59 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.99100271 |
| 60 | DNA topological change (GO:0006265) | 2.98205273 |
| 61 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.98075262 |
| 62 | DNA strand elongation (GO:0022616) | 2.97785822 |
| 63 | histone mRNA metabolic process (GO:0008334) | 2.96618477 |
| 64 | negative regulation of DNA recombination (GO:0045910) | 2.96307845 |
| 65 | mitotic G2 DNA damage checkpoint (GO:0007095) | 2.94495108 |
| 66 | intra-S DNA damage checkpoint (GO:0031573) | 2.92893133 |
| 67 | histone H3-K9 modification (GO:0061647) | 2.92776006 |
| 68 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.91122260 |
| 69 | alternative mRNA splicing, via spliceosome (GO:0000380) | 2.90496082 |
| 70 | regulation of histone H3-K4 methylation (GO:0051569) | 2.89655935 |
| 71 | motile cilium assembly (GO:0044458) | 2.88676006 |
| 72 | microtubule depolymerization (GO:0007019) | 2.87021944 |
| 73 | regulation of RNA export from nucleus (GO:0046831) | 2.85930388 |
| 74 | DNA unwinding involved in DNA replication (GO:0006268) | 2.83631623 |
| 75 | axonemal dynein complex assembly (GO:0070286) | 2.82427112 |
| 76 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.77141708 |
| 77 | regulation of histone methylation (GO:0031060) | 2.72294254 |
| 78 | negative regulation of RNA splicing (GO:0033119) | 2.71360390 |
| 79 | histone H3-K4 methylation (GO:0051568) | 2.70997542 |
| 80 | RNA stabilization (GO:0043489) | 2.69708278 |
| 81 | mRNA stabilization (GO:0048255) | 2.69708278 |
| 82 | histone lysine methylation (GO:0034968) | 2.66194067 |
| 83 | regulation of telomere maintenance (GO:0032204) | 2.65942502 |
| 84 | DNA geometric change (GO:0032392) | 2.65801152 |
| 85 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.65030525 |
| 86 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.65030525 |
| 87 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.65030525 |
| 88 | DNA duplex unwinding (GO:0032508) | 2.64446923 |
| 89 | positive regulation of histone H3-K4 methylation (GO:0051571) | 2.64296248 |
| 90 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.63605039 |
| 91 | RNA-dependent DNA replication (GO:0006278) | 2.60392629 |
| 92 | ATP-dependent chromatin remodeling (GO:0043044) | 2.60170806 |
| 93 | regulation of centriole replication (GO:0046599) | 2.59871112 |
| 94 | peptidyl-lysine methylation (GO:0018022) | 2.58718281 |
| 95 | meiotic chromosome segregation (GO:0045132) | 2.58491252 |
| 96 | poly(A)+ mRNA export from nucleus (GO:0016973) | 2.57878417 |
| 97 | maturation of SSU-rRNA (GO:0030490) | 2.57459218 |
| 98 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.57081698 |
| 99 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.57081698 |
| 100 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.54034507 |
| 101 | DNA conformation change (GO:0071103) | 2.52454324 |
| 102 | histone H2A acetylation (GO:0043968) | 2.52451247 |
| 103 | centriole replication (GO:0007099) | 2.52010623 |
| 104 | kinetochore assembly (GO:0051382) | 2.49853945 |
| 105 | protein localization to chromosome, centromeric region (GO:0071459) | 2.48944560 |
| 106 | DNA alkylation (GO:0006305) | 2.48420721 |
| 107 | DNA methylation (GO:0006306) | 2.48420721 |
| 108 | V(D)J recombination (GO:0033151) | 2.47900289 |
| 109 | termination of RNA polymerase II transcription (GO:0006369) | 2.47655455 |
| 110 | RNA splicing, via transesterification reactions (GO:0000375) | 2.47514231 |
| 111 | ncRNA catabolic process (GO:0034661) | 2.47117497 |
| 112 | mRNA splicing, via spliceosome (GO:0000398) | 2.47108536 |
| 113 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.47108536 |
| 114 | regulation of mRNA stability (GO:0043488) | 2.47105002 |
| 115 | acrosome assembly (GO:0001675) | 2.46869322 |
| 116 | mitotic metaphase plate congression (GO:0007080) | 2.45776620 |
| 117 | spermatid nucleus differentiation (GO:0007289) | 2.45363555 |
| 118 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.45046090 |
| 119 | negative regulation of mRNA processing (GO:0050686) | 2.43763440 |
| 120 | centriole assembly (GO:0098534) | 2.43639118 |
| 121 | histone methylation (GO:0016571) | 2.43467723 |
| 122 | regulation of histone H3-K27 methylation (GO:0061085) | 2.42433677 |
| 123 | DNA replication initiation (GO:0006270) | 2.41078741 |
| 124 | sister chromatid segregation (GO:0000819) | 2.39688260 |
| 125 | DNA packaging (GO:0006323) | 2.39054599 |
| 126 | replication fork processing (GO:0031297) | 2.38602255 |
| 127 | mRNA export from nucleus (GO:0006406) | 2.38312065 |
| 128 | protein localization to kinetochore (GO:0034501) | 2.38250850 |
| 129 | positive regulation of histone methylation (GO:0031062) | 2.38146951 |
| 130 | regulation of mRNA processing (GO:0050684) | 2.36878730 |
| 131 | mitotic chromosome condensation (GO:0007076) | 2.36215681 |
| 132 | nucleus organization (GO:0006997) | 2.35073431 |
| 133 | metaphase plate congression (GO:0051310) | 2.34806571 |
| 134 | regulation of mRNA splicing, via spliceosome (GO:0048024) | 2.33785372 |
| 135 | RNA export from nucleus (GO:0006405) | 2.33439312 |
| 136 | DNA replication-independent nucleosome organization (GO:0034724) | 2.30625080 |
| 137 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.30625080 |
| 138 | termination of RNA polymerase I transcription (GO:0006363) | 2.29845407 |
| 139 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.28334989 |
| 140 | rRNA catabolic process (GO:0016075) | 2.27460123 |
| 141 | regulation of DNA-dependent DNA replication (GO:0090329) | 2.26865626 |
| 142 | histone exchange (GO:0043486) | 2.26690755 |
| 143 | regulation of RNA stability (GO:0043487) | 2.26681032 |
| 144 | protein-DNA complex disassembly (GO:0032986) | 2.26623819 |
| 145 | nucleosome disassembly (GO:0006337) | 2.26623819 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.28030195 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.76270674 |
| 3 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.55554733 |
| 4 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 3.18728239 |
| 5 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.93135299 |
| 6 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.92175961 |
| 7 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.77640438 |
| 8 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.77520025 |
| 9 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.54954679 |
| 10 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.53045810 |
| 11 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.49099901 |
| 12 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.42028672 |
| 13 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.06814953 |
| 14 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.04113921 |
| 15 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.03254656 |
| 16 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.96547283 |
| 17 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.96221828 |
| 18 | FUS_26573619_Chip-Seq_HEK293_Human | 1.93213408 |
| 19 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.76281873 |
| 20 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.66528781 |
| 21 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.66071210 |
| 22 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.62998730 |
| 23 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.57881555 |
| 24 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.53164554 |
| 25 | EWS_26573619_Chip-Seq_HEK293_Human | 1.50056108 |
| 26 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.49000903 |
| 27 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.48701182 |
| 28 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.44401793 |
| 29 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.44184648 |
| 30 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.44033097 |
| 31 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.43478391 |
| 32 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.43323957 |
| 33 | VDR_22108803_ChIP-Seq_LS180_Human | 1.39693169 |
| 34 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.38115560 |
| 35 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.37914407 |
| 36 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.36242035 |
| 37 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.35148333 |
| 38 | MYC_22102868_ChIP-Seq_BL_Human | 1.34489204 |
| 39 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.31474917 |
| 40 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.30106944 |
| 41 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.29474821 |
| 42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.29261870 |
| 43 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.26662237 |
| 44 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.23870881 |
| 45 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.22157301 |
| 46 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.21356658 |
| 47 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.20964384 |
| 48 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.20543566 |
| 49 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.20179923 |
| 50 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.18701131 |
| 51 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.18479815 |
| 52 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.16975887 |
| 53 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.15291217 |
| 54 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.14439206 |
| 55 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.13847414 |
| 56 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.12974471 |
| 57 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.12034396 |
| 58 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.11663208 |
| 59 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.11334077 |
| 60 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.11305477 |
| 61 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.09694320 |
| 62 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.09486008 |
| 63 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.08133795 |
| 64 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.07580494 |
| 65 | * MYB_26560356_Chip-Seq_TH1_Human | 1.06590165 |
| 66 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.06540876 |
| 67 | P300_19829295_ChIP-Seq_ESCs_Human | 1.06252425 |
| 68 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.05431800 |
| 69 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.05074072 |
| 70 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.04274080 |
| 71 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.02398327 |
| 72 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.01044878 |
| 73 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.00314424 |
| 74 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.00202915 |
| 75 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.99439604 |
| 76 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.99288112 |
| 77 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.98509505 |
| 78 | MYB_26560356_Chip-Seq_TH2_Human | 0.98453790 |
| 79 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.98267507 |
| 80 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.97532820 |
| 81 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.96193943 |
| 82 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.95972898 |
| 83 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.95792067 |
| 84 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.95739840 |
| 85 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.95532200 |
| 86 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94810113 |
| 87 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.94780009 |
| 88 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.94524714 |
| 89 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.94220318 |
| 90 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.93730456 |
| 91 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.93465523 |
| 92 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.93135683 |
| 93 | GATA1_22025678_ChIP-Seq_K562_Human | 0.93021531 |
| 94 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.92002193 |
| 95 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.91664160 |
| 96 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.91634408 |
| 97 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.90322686 |
| 98 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.90056763 |
| 99 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.88008532 |
| 100 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.88008532 |
| 101 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.87726711 |
| 102 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.87503450 |
| 103 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.86824262 |
| 104 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.86784317 |
| 105 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.86382121 |
| 106 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.86203102 |
| 107 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.84808300 |
| 108 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.83843164 |
| 109 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.83408051 |
| 110 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.83347494 |
| 111 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.82823427 |
| 112 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.82768712 |
| 113 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.82514997 |
| 114 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.82334056 |
| 115 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.82141017 |
| 116 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.82018694 |
| 117 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.80739705 |
| 118 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.79945975 |
| 119 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.79662637 |
| 120 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.79050492 |
| 121 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.78836347 |
| 122 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.78704450 |
| 123 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.78306190 |
| 124 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.78155359 |
| 125 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.77397472 |
| 126 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.76528825 |
| 127 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.76261638 |
| 128 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.75676179 |
| 129 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.75199768 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008057_abnormal_DNA_replication | 4.01711775 |
| 2 | MP0008877_abnormal_DNA_methylation | 3.28218307 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.10778512 |
| 4 | MP0008058_abnormal_DNA_repair | 2.89470929 |
| 5 | MP0003787_abnormal_imprinting | 2.86114907 |
| 6 | MP0003693_abnormal_embryo_hatching | 2.73814135 |
| 7 | MP0006292_abnormal_olfactory_placode | 2.73732834 |
| 8 | MP0003111_abnormal_nucleus_morphology | 2.67975575 |
| 9 | MP0002396_abnormal_hematopoietic_system | 2.54462959 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.44362274 |
| 11 | MP0003077_abnormal_cell_cycle | 2.35261510 |
| 12 | MP0009379_abnormal_foot_pigmentation | 2.12527527 |
| 13 | MP0000569_abnormal_digit_pigmentation | 2.09167425 |
| 14 | MP0004957_abnormal_blastocyst_morpholog | 2.02629767 |
| 15 | MP0003121_genomic_imprinting | 1.99503857 |
| 16 | MP0005367_renal/urinary_system_phenotyp | 1.78286737 |
| 17 | MP0000516_abnormal_urinary_system | 1.78286737 |
| 18 | MP0003950_abnormal_plasma_membrane | 1.74505381 |
| 19 | MP0003941_abnormal_skin_development | 1.69242657 |
| 20 | MP0003123_paternal_imprinting | 1.67823880 |
| 21 | MP0000537_abnormal_urethra_morphology | 1.56981417 |
| 22 | MP0004808_abnormal_hematopoietic_stem | 1.56968703 |
| 23 | MP0005410_abnormal_fertilization | 1.47833185 |
| 24 | MP0003763_abnormal_thymus_physiology | 1.46805024 |
| 25 | MP0003315_abnormal_perineum_morphology | 1.44186935 |
| 26 | MP0004185_abnormal_adipocyte_glucose | 1.41967412 |
| 27 | MP0001188_hyperpigmentation | 1.38159534 |
| 28 | MP0002009_preneoplasia | 1.36445060 |
| 29 | MP0003718_maternal_effect | 1.33212621 |
| 30 | MP0008995_early_reproductive_senescence | 1.32945564 |
| 31 | MP0000383_abnormal_hair_follicle | 1.28692350 |
| 32 | MP0009697_abnormal_copulation | 1.27640029 |
| 33 | MP0001730_embryonic_growth_arrest | 1.27080737 |
| 34 | MP0003890_abnormal_embryonic-extraembry | 1.26450149 |
| 35 | MP0000703_abnormal_thymus_morphology | 1.25971606 |
| 36 | MP0002210_abnormal_sex_determination | 1.25324592 |
| 37 | MP0000350_abnormal_cell_proliferation | 1.23576851 |
| 38 | MP0002254_reproductive_system_inflammat | 1.21221018 |
| 39 | MP0005409_darkened_coat_color | 1.20867945 |
| 40 | MP0001929_abnormal_gametogenesis | 1.20041885 |
| 41 | MP0005075_abnormal_melanosome_morpholog | 1.18462811 |
| 42 | MP0002796_impaired_skin_barrier | 1.17097027 |
| 43 | MP0003937_abnormal_limbs/digits/tail_de | 1.16994164 |
| 44 | MP0005076_abnormal_cell_differentiation | 1.15357623 |
| 45 | MP0002084_abnormal_developmental_patter | 1.11931200 |
| 46 | MP0002166_altered_tumor_susceptibility | 1.11640621 |
| 47 | MP0002398_abnormal_bone_marrow | 1.09063738 |
| 48 | MP0010307_abnormal_tumor_latency | 1.08658052 |
| 49 | MP0001293_anophthalmia | 1.07281854 |
| 50 | MP0003698_abnormal_male_reproductive | 1.07064612 |
| 51 | MP0001672_abnormal_embryogenesis/_devel | 1.06918810 |
| 52 | MP0005380_embryogenesis_phenotype | 1.06918810 |
| 53 | MP0009703_decreased_birth_body | 1.06558525 |
| 54 | MP0008932_abnormal_embryonic_tissue | 1.06303733 |
| 55 | MP0004197_abnormal_fetal_growth/weight/ | 1.05295390 |
| 56 | MP0010678_abnormal_skin_adnexa | 1.04958049 |
| 57 | MP0001145_abnormal_male_reproductive | 1.00656444 |
| 58 | MP0002019_abnormal_tumor_incidence | 1.00632143 |
| 59 | MP0003786_premature_aging | 1.00358291 |
| 60 | MP0003938_abnormal_ear_development | 0.98566178 |
| 61 | MP0002085_abnormal_embryonic_tissue | 0.97577105 |
| 62 | MP0005174_abnormal_tail_pigmentation | 0.96044934 |
| 63 | MP0005499_abnormal_olfactory_system | 0.95028081 |
| 64 | MP0005394_taste/olfaction_phenotype | 0.95028081 |
| 65 | MP0010352_gastrointestinal_tract_polyps | 0.94803876 |
| 66 | MP0001485_abnormal_pinna_reflex | 0.94594514 |
| 67 | MP0003943_abnormal_hepatobiliary_system | 0.94375373 |
| 68 | MP0001697_abnormal_embryo_size | 0.93761812 |
| 69 | MP0000432_abnormal_head_morphology | 0.92725332 |
| 70 | MP0003984_embryonic_growth_retardation | 0.91838609 |
| 71 | MP0002088_abnormal_embryonic_growth/wei | 0.91735005 |
| 72 | MP0003935_abnormal_craniofacial_develop | 0.91728843 |
| 73 | MP0002102_abnormal_ear_morphology | 0.91585358 |
| 74 | MP0002006_tumorigenesis | 0.90897551 |
| 75 | MP0001286_abnormal_eye_development | 0.90786470 |
| 76 | MP0006035_abnormal_mitochondrial_morpho | 0.90016178 |
| 77 | MP0006072_abnormal_retinal_apoptosis | 0.89838005 |
| 78 | MP0001177_atelectasis | 0.87773531 |
| 79 | MP0000313_abnormal_cell_death | 0.87590680 |
| 80 | MP0000049_abnormal_middle_ear | 0.87051227 |
| 81 | MP0002751_abnormal_autonomic_nervous | 0.86871401 |
| 82 | MP0003221_abnormal_cardiomyocyte_apopto | 0.85872252 |
| 83 | MP0000653_abnormal_sex_gland | 0.85412753 |
| 84 | MP0003122_maternal_imprinting | 0.84112652 |
| 85 | MP0002095_abnormal_skin_pigmentation | 0.83847873 |
| 86 | MP0000015_abnormal_ear_pigmentation | 0.83736020 |
| 87 | MP0001800_abnormal_humoral_immune | 0.83046063 |
| 88 | MP0000631_abnormal_neuroendocrine_gland | 0.82615168 |
| 89 | MP0002277_abnormal_respiratory_mucosa | 0.82534604 |
| 90 | MP0002233_abnormal_nose_morphology | 0.82471660 |
| 91 | MP0002177_abnormal_outer_ear | 0.81143211 |
| 92 | MP0002086_abnormal_extraembryonic_tissu | 0.79617401 |
| 93 | MP0003755_abnormal_palate_morphology | 0.79444929 |
| 94 | MP0003567_abnormal_fetal_cardiomyocyte | 0.78988684 |
| 95 | MP0002098_abnormal_vibrissa_morphology | 0.78363791 |
| 96 | MP0001853_heart_inflammation | 0.78075072 |
| 97 | MP0003385_abnormal_body_wall | 0.77324196 |
| 98 | MP0002722_abnormal_immune_system | 0.77025832 |
| 99 | MP0009333_abnormal_splenocyte_physiolog | 0.76826569 |
| 100 | MP0000566_synostosis | 0.76387347 |
| 101 | MP0004742_abnormal_vestibular_system | 0.76256559 |
| 102 | MP0009278_abnormal_bone_marrow | 0.76149201 |
| 103 | MP0005646_abnormal_pituitary_gland | 0.76019857 |
| 104 | MP0005397_hematopoietic_system_phenotyp | 0.75254108 |
| 105 | MP0001545_abnormal_hematopoietic_system | 0.75254108 |
| 106 | MP0002938_white_spotting | 0.75227805 |
| 107 | MP0000716_abnormal_immune_system | 0.74744303 |
| 108 | MP0002111_abnormal_tail_morphology | 0.73803913 |
| 109 | MP0002420_abnormal_adaptive_immunity | 0.72294050 |
| 110 | MP0002080_prenatal_lethality | 0.72001880 |
| 111 | MP0002697_abnormal_eye_size | 0.71728675 |
| 112 | MP0001819_abnormal_immune_cell | 0.70138549 |
| 113 | MP0000428_abnormal_craniofacial_morphol | 0.69774821 |
| 114 | MP0005671_abnormal_response_to | 0.69415346 |
| 115 | MP0005501_abnormal_skin_physiology | 0.69052684 |
| 116 | MP0002452_abnormal_antigen_presenting | 0.68007109 |
| 117 | MP0003861_abnormal_nervous_system | 0.67649728 |
| 118 | MP0004264_abnormal_extraembryonic_tissu | 0.67549379 |
| 119 | MP0000465_gastrointestinal_hemorrhage | 0.67341819 |
| 120 | MP0008789_abnormal_olfactory_epithelium | 0.66982072 |
| 121 | MP0000689_abnormal_spleen_morphology | 0.66968457 |
| 122 | MP0004134_abnormal_chest_morphology | 0.66930186 |
| 123 | MP0009672_abnormal_birth_weight | 0.66848710 |
| 124 | MP0005384_cellular_phenotype | 0.62451875 |
| 125 | MP0002429_abnormal_blood_cell | 0.61000765 |
| 126 | MP0001119_abnormal_female_reproductive | 0.59640277 |
| 127 | MP0000358_abnormal_cell_content/ | 0.56699887 |
| 128 | MP0006036_abnormal_mitochondrial_physio | 0.56512222 |
| 129 | MP0000579_abnormal_nail_morphology | 0.56464350 |
| 130 | MP0008770_decreased_survivor_rate | 0.55161138 |
| 131 | MP0004147_increased_porphyrin_level | 0.53733966 |
| 132 | MP0003115_abnormal_respiratory_system | 0.52639286 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Volvulus (HP:0002580) | 4.21035265 |
| 2 | Absent/shortened dynein arms (HP:0200106) | 3.74404962 |
| 3 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.74404962 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 3.68018541 |
| 5 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.46152768 |
| 6 | Abnormality of the fingertips (HP:0001211) | 3.36613158 |
| 7 | Chromsome breakage (HP:0040012) | 3.05972467 |
| 8 | Ectopic kidney (HP:0000086) | 3.04395089 |
| 9 | Abnormality of the labia minora (HP:0012880) | 2.96994876 |
| 10 | Lip pit (HP:0100267) | 2.81957510 |
| 11 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.73917849 |
| 12 | Medulloblastoma (HP:0002885) | 2.63083657 |
| 13 | Abnormality of DNA repair (HP:0003254) | 2.59739245 |
| 14 | Multiple enchondromatosis (HP:0005701) | 2.43182953 |
| 15 | Abnormality of the nasal septum (HP:0000419) | 2.41368038 |
| 16 | Supernumerary ribs (HP:0005815) | 2.39764312 |
| 17 | Supernumerary bones of the axial skeleton (HP:0009144) | 2.36274504 |
| 18 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.34043154 |
| 19 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.34043154 |
| 20 | Small intestinal stenosis (HP:0012848) | 2.33358560 |
| 21 | Duodenal stenosis (HP:0100867) | 2.33358560 |
| 22 | Abnormality of homocysteine metabolism (HP:0010919) | 2.25777312 |
| 23 | Homocystinuria (HP:0002156) | 2.25777312 |
| 24 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.16873472 |
| 25 | Ependymoma (HP:0002888) | 2.16563509 |
| 26 | Biliary tract neoplasm (HP:0100574) | 2.16420567 |
| 27 | Increased hepatocellular lipid droplets (HP:0006565) | 2.14075737 |
| 28 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.14014521 |
| 29 | Abnormality of the duodenum (HP:0002246) | 2.12175946 |
| 30 | Neoplasm of the adrenal cortex (HP:0100641) | 2.10201607 |
| 31 | Proximal placement of thumb (HP:0009623) | 2.09335453 |
| 32 | Clubbing of toes (HP:0100760) | 2.08996186 |
| 33 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.04074718 |
| 34 | Rhabdomyosarcoma (HP:0002859) | 2.03051173 |
| 35 | IgM deficiency (HP:0002850) | 2.01142084 |
| 36 | Long eyelashes (HP:0000527) | 2.00471981 |
| 37 | Abnormality of the preputium (HP:0100587) | 2.00390342 |
| 38 | Acute lymphatic leukemia (HP:0006721) | 2.00074252 |
| 39 | Triphalangeal thumb (HP:0001199) | 1.99954385 |
| 40 | Stomach cancer (HP:0012126) | 1.99306798 |
| 41 | Myelodysplasia (HP:0002863) | 1.98157769 |
| 42 | Abnormality of chromosome stability (HP:0003220) | 1.97072720 |
| 43 | Acute myeloid leukemia (HP:0004808) | 1.95720747 |
| 44 | Septo-optic dysplasia (HP:0100842) | 1.95186686 |
| 45 | Absent frontal sinuses (HP:0002688) | 1.93764829 |
| 46 | Cellular immunodeficiency (HP:0005374) | 1.93070120 |
| 47 | Pancreatic fibrosis (HP:0100732) | 1.92253449 |
| 48 | Increased nuchal translucency (HP:0010880) | 1.92203418 |
| 49 | Patellar aplasia (HP:0006443) | 1.92124534 |
| 50 | Deviation of the thumb (HP:0009603) | 1.92066478 |
| 51 | Prominent nose (HP:0000448) | 1.92051410 |
| 52 | Abnormality of the septum pellucidum (HP:0007375) | 1.91469559 |
| 53 | Progressive external ophthalmoplegia (HP:0000590) | 1.91305390 |
| 54 | Macrocytic anemia (HP:0001972) | 1.91128779 |
| 55 | Pancreatic cysts (HP:0001737) | 1.90530794 |
| 56 | Supernumerary spleens (HP:0009799) | 1.89660934 |
| 57 | Cafe-au-lait spot (HP:0000957) | 1.88774001 |
| 58 | Horseshoe kidney (HP:0000085) | 1.88009161 |
| 59 | Nephronophthisis (HP:0000090) | 1.87464836 |
| 60 | T lymphocytopenia (HP:0005403) | 1.86991879 |
| 61 | Breast hypoplasia (HP:0003187) | 1.85985689 |
| 62 | Embryonal neoplasm (HP:0002898) | 1.85369691 |
| 63 | Gonadotropin excess (HP:0000837) | 1.84001665 |
| 64 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.83724458 |
| 65 | Duplicated collecting system (HP:0000081) | 1.83634991 |
| 66 | Aplasia cutis congenita (HP:0001057) | 1.83152277 |
| 67 | Hepatoblastoma (HP:0002884) | 1.82856087 |
| 68 | Impulsivity (HP:0100710) | 1.82324224 |
| 69 | Hypoplastic labia majora (HP:0000059) | 1.82292325 |
| 70 | Neoplasm of the colon (HP:0100273) | 1.81626425 |
| 71 | Lipid accumulation in hepatocytes (HP:0006561) | 1.81380204 |
| 72 | Abnormal hair whorl (HP:0010721) | 1.80933079 |
| 73 | Abnormal number of incisors (HP:0011064) | 1.79435035 |
| 74 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.78135052 |
| 75 | Low anterior hairline (HP:0000294) | 1.77076318 |
| 76 | Protruding tongue (HP:0010808) | 1.76704511 |
| 77 | Stenosis of the external auditory canal (HP:0000402) | 1.76519728 |
| 78 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.76374175 |
| 79 | Aqueductal stenosis (HP:0002410) | 1.75359958 |
| 80 | Abnormality of the renal collecting system (HP:0004742) | 1.74878308 |
| 81 | Urethral obstruction (HP:0000796) | 1.74414431 |
| 82 | Combined immunodeficiency (HP:0005387) | 1.74252057 |
| 83 | Deep philtrum (HP:0002002) | 1.72721954 |
| 84 | Chronic bronchitis (HP:0004469) | 1.72558551 |
| 85 | Poikiloderma (HP:0001029) | 1.71472119 |
| 86 | Growth hormone deficiency (HP:0000824) | 1.71429031 |
| 87 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.71065408 |
| 88 | Asplenia (HP:0001746) | 1.71060991 |
| 89 | Intestinal atresia (HP:0011100) | 1.70835767 |
| 90 | B lymphocytopenia (HP:0010976) | 1.70698450 |
| 91 | Abnormality of B cell number (HP:0010975) | 1.70698450 |
| 92 | Papillary thyroid carcinoma (HP:0002895) | 1.70589133 |
| 93 | Anal stenosis (HP:0002025) | 1.70367478 |
| 94 | Absent thumb (HP:0009777) | 1.69646131 |
| 95 | Macroorchidism (HP:0000053) | 1.69476015 |
| 96 | Cleft eyelid (HP:0000625) | 1.69291802 |
| 97 | Glioma (HP:0009733) | 1.69031001 |
| 98 | Basal cell carcinoma (HP:0002671) | 1.68913729 |
| 99 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.68195106 |
| 100 | Meckel diverticulum (HP:0002245) | 1.68041371 |
| 101 | Abnormality of the incisor (HP:0000676) | 1.68032685 |
| 102 | Abnormality of the renal medulla (HP:0100957) | 1.67811652 |
| 103 | Reticulocytopenia (HP:0001896) | 1.66976887 |
| 104 | Abnormality of the carotid arteries (HP:0005344) | 1.66701366 |
| 105 | Embryonal renal neoplasm (HP:0011794) | 1.66481443 |
| 106 | Short middle phalanx of the 5th finger (HP:0004220) | 1.66382008 |
| 107 | Abnormality of the frontal sinuses (HP:0002687) | 1.64873065 |
| 108 | Abnormal ciliary motility (HP:0012262) | 1.64775426 |
| 109 | Ectropion (HP:0000656) | 1.64461536 |
| 110 | Abnormality of the labia majora (HP:0012881) | 1.64035918 |
| 111 | Neoplasm of striated muscle (HP:0009728) | 1.63850053 |
| 112 | Entropion (HP:0000621) | 1.63492314 |
| 113 | Oligodactyly (hands) (HP:0001180) | 1.62899288 |
| 114 | Fibular hypoplasia (HP:0003038) | 1.62712679 |
| 115 | Neoplasm of the small intestine (HP:0100833) | 1.62464666 |
| 116 | Missing ribs (HP:0000921) | 1.62404150 |
| 117 | Pallor (HP:0000980) | 1.62014258 |
| 118 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.61845714 |
| 119 | Spinal cord lesions (HP:0100561) | 1.61374760 |
| 120 | Syringomyelia (HP:0003396) | 1.61374760 |
| 121 | Thyroiditis (HP:0100646) | 1.61314793 |
| 122 | Sloping forehead (HP:0000340) | 1.61299125 |
| 123 | Sandal gap (HP:0001852) | 1.60520487 |
| 124 | Severe combined immunodeficiency (HP:0004430) | 1.60310927 |
| 125 | Optic nerve hypoplasia (HP:0000609) | 1.60222504 |
| 126 | Curly hair (HP:0002212) | 1.59518529 |
| 127 | Cystic hygroma (HP:0000476) | 1.59485655 |
| 128 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.59377892 |
| 129 | Abnormal lung lobation (HP:0002101) | 1.59139921 |
| 130 | Rhinitis (HP:0012384) | 1.58246161 |
| 131 | Facial cleft (HP:0002006) | 1.58061576 |
| 132 | Microtia (HP:0008551) | 1.57612691 |
| 133 | Gastrointestinal atresia (HP:0002589) | 1.56614158 |
| 134 | Cortical dysplasia (HP:0002539) | 1.56061392 |
| 135 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.55643011 |
| 136 | Astrocytoma (HP:0009592) | 1.55164880 |
| 137 | Abnormality of the astrocytes (HP:0100707) | 1.55164880 |
| 138 | Facial hemangioma (HP:0000329) | 1.52948355 |
| 139 | Squamous cell carcinoma (HP:0002860) | 1.52801711 |
| 140 | Colon cancer (HP:0003003) | 1.52766491 |
| 141 | Bronchiectasis (HP:0002110) | 1.52690306 |
| 142 | Bronchitis (HP:0012387) | 1.52423697 |
| 143 | Abnormality of the ileum (HP:0001549) | 1.52298851 |
| 144 | Abnormality of midbrain morphology (HP:0002418) | 1.51730993 |
| 145 | Molar tooth sign on MRI (HP:0002419) | 1.51730993 |
| 146 | Panhypogammaglobulinemia (HP:0003139) | 1.50856814 |
| 147 | Intestinal malrotation (HP:0002566) | 1.49803329 |
| 148 | Sparse scalp hair (HP:0002209) | 1.49647053 |
| 149 | Hypoplasia of the radius (HP:0002984) | 1.48990075 |
| 150 | Tubulointerstitial nephritis (HP:0001970) | 1.48701620 |
| 151 | Atresia of the external auditory canal (HP:0000413) | 1.47985881 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PNCK | 3.79716227 |
| 2 | MKNK2 | 3.78165249 |
| 3 | CDK12 | 3.60867083 |
| 4 | CDC7 | 3.55397057 |
| 5 | MST4 | 3.50336221 |
| 6 | MKNK1 | 3.17879834 |
| 7 | STK16 | 3.06030159 |
| 8 | SRPK1 | 2.66159323 |
| 9 | NUAK1 | 2.57817132 |
| 10 | BRD4 | 2.34410839 |
| 11 | LATS1 | 2.03538859 |
| 12 | PRPF4B | 1.91999807 |
| 13 | TAF1 | 1.87187349 |
| 14 | TXK | 1.84657656 |
| 15 | TNIK | 1.76951532 |
| 16 | MAP3K14 | 1.72776758 |
| 17 | NEK2 | 1.63103669 |
| 18 | IRAK4 | 1.61465789 |
| 19 | STK38L | 1.60313640 |
| 20 | ATR | 1.59515474 |
| 21 | BMPR1B | 1.57998268 |
| 22 | MAP4K1 | 1.46813079 |
| 23 | WEE1 | 1.44108738 |
| 24 | CDK7 | 1.36676294 |
| 25 | MAP3K10 | 1.34711289 |
| 26 | SIK2 | 1.34332345 |
| 27 | PASK | 1.33496996 |
| 28 | TTK | 1.29659081 |
| 29 | ATM | 1.28815393 |
| 30 | * CHEK1 | 1.26239771 |
| 31 | STK3 | 1.25320647 |
| 32 | ERBB3 | 1.20786591 |
| 33 | CLK1 | 1.19011541 |
| 34 | CDK3 | 1.17640143 |
| 35 | PLK3 | 1.16999098 |
| 36 | YES1 | 1.16213780 |
| 37 | STK24 | 1.16213633 |
| 38 | PLK4 | 1.16132493 |
| 39 | NEK1 | 1.09913780 |
| 40 | EIF2AK1 | 1.09310094 |
| 41 | AURKB | 1.03761816 |
| 42 | TSSK6 | 1.03399789 |
| 43 | ALK | 1.03363305 |
| 44 | DYRK3 | 1.02762805 |
| 45 | EIF2AK2 | 1.02697044 |
| 46 | BUB1 | 1.02457439 |
| 47 | PLK1 | 0.92946766 |
| 48 | CASK | 0.92275035 |
| 49 | RPS6KA4 | 0.91607300 |
| 50 | STK4 | 0.89175367 |
| 51 | CDK2 | 0.88833606 |
| 52 | ZAK | 0.86683172 |
| 53 | EIF2AK3 | 0.86601089 |
| 54 | MAP3K4 | 0.86230466 |
| 55 | TNK2 | 0.85817986 |
| 56 | STK10 | 0.84261324 |
| 57 | WNK3 | 0.83599909 |
| 58 | CHEK2 | 0.81759833 |
| 59 | CDK1 | 0.78655510 |
| 60 | CHUK | 0.78293435 |
| 61 | RPS6KB2 | 0.77170211 |
| 62 | CSNK1E | 0.76322832 |
| 63 | VRK1 | 0.73810686 |
| 64 | CSNK2A2 | 0.73525938 |
| 65 | ACVR1B | 0.72698830 |
| 66 | CSNK1D | 0.71364512 |
| 67 | CDK4 | 0.69851606 |
| 68 | CSNK1A1L | 0.68466122 |
| 69 | PRKDC | 0.68331880 |
| 70 | TEC | 0.67904738 |
| 71 | TAOK3 | 0.67846445 |
| 72 | PIM1 | 0.66895575 |
| 73 | FRK | 0.66174872 |
| 74 | STK39 | 0.66057568 |
| 75 | FGFR1 | 0.63403354 |
| 76 | AKT3 | 0.63167735 |
| 77 | BMPR2 | 0.61657305 |
| 78 | CDK6 | 0.61192713 |
| 79 | MAPK14 | 0.60396143 |
| 80 | IRAK3 | 0.60334516 |
| 81 | PLK2 | 0.60002390 |
| 82 | BLK | 0.58387523 |
| 83 | NME1 | 0.58190943 |
| 84 | CAMK1G | 0.56889072 |
| 85 | GSK3B | 0.56232554 |
| 86 | CDK8 | 0.56114051 |
| 87 | FES | 0.55980686 |
| 88 | LCK | 0.55923822 |
| 89 | TRPM7 | 0.54971764 |
| 90 | TGFBR1 | 0.54896943 |
| 91 | PBK | 0.51492901 |
| 92 | CDK9 | 0.51009658 |
| 93 | HIPK2 | 0.49192659 |
| 94 | RIPK4 | 0.48774928 |
| 95 | MAP2K2 | 0.46572843 |
| 96 | PAK3 | 0.46235409 |
| 97 | MARK3 | 0.45480167 |
| 98 | NLK | 0.45045075 |
| 99 | BRSK2 | 0.44318126 |
| 100 | AKT1 | 0.43710965 |
| 101 | DYRK1A | 0.43325855 |
| 102 | IRAK1 | 0.42973057 |
| 103 | OXSR1 | 0.42695056 |
| 104 | WNK1 | 0.42034210 |
| 105 | CDK19 | 0.41160529 |
| 106 | DMPK | 0.41060501 |
| 107 | PDGFRB | 0.40526678 |
| 108 | CSNK2A1 | 0.40492756 |
| 109 | NEK6 | 0.40148216 |
| 110 | RPS6KA5 | 0.39937080 |
| 111 | SGK2 | 0.39915723 |
| 112 | CAMK1D | 0.39809665 |
| 113 | MAPK10 | 0.39713031 |
| 114 | BCR | 0.39451929 |
| 115 | PRKG1 | 0.38595865 |
| 116 | MTOR | 0.38298720 |
| 117 | TRIM28 | 0.38167792 |
| 118 | SGK1 | 0.37039842 |
| 119 | IRAK2 | 0.36659208 |
| 120 | IKBKB | 0.35563344 |
| 121 | WNK4 | 0.35181349 |
| 122 | BTK | 0.34303027 |
| 123 | FGR | 0.33942917 |
| 124 | CSK | 0.32084334 |
| 125 | ERBB2 | 0.32030243 |
| 126 | RPS6KB1 | 0.31150692 |
| 127 | MAPK8 | 0.30899172 |
| 128 | SYK | 0.30063754 |
| 129 | BRAF | 0.29734158 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Spliceosome_Homo sapiens_hsa03040 | 2.70388855 |
| 2 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.54797702 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.51637812 |
| 4 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.40758396 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 2.32713634 |
| 6 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.26720409 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.26639414 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.17751476 |
| 9 | Basal transcription factors_Homo sapiens_hsa03022 | 2.15690068 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.04531290 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 1.95058006 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.92868944 |
| 13 | RNA degradation_Homo sapiens_hsa03018 | 1.83939582 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 1.81535504 |
| 15 | Proteasome_Homo sapiens_hsa03050 | 1.77354291 |
| 16 | Base excision repair_Homo sapiens_hsa03410 | 1.73210621 |
| 17 | RNA polymerase_Homo sapiens_hsa03020 | 1.61800837 |
| 18 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.50514373 |
| 19 | Ribosome_Homo sapiens_hsa03010 | 1.48185086 |
| 20 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.34691683 |
| 21 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.21868529 |
| 22 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.18493331 |
| 23 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.14467566 |
| 24 | Measles_Homo sapiens_hsa05162 | 1.10257406 |
| 25 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.09478899 |
| 26 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.06911643 |
| 27 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.05520004 |
| 28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.04561761 |
| 29 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.02704700 |
| 30 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.01203981 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.00742754 |
| 32 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.99652386 |
| 33 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.97532414 |
| 34 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.95551366 |
| 35 | Prostate cancer_Homo sapiens_hsa05215 | 0.94245677 |
| 36 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.94239368 |
| 37 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.90260727 |
| 38 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.89591417 |
| 39 | HTLV-I infection_Homo sapiens_hsa05166 | 0.88502239 |
| 40 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.87572504 |
| 41 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.87392728 |
| 42 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.86736898 |
| 43 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.85948564 |
| 44 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.82731128 |
| 45 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.82707685 |
| 46 | Asthma_Homo sapiens_hsa05310 | 0.80466967 |
| 47 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.80320776 |
| 48 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.76149038 |
| 49 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.75345771 |
| 50 | Phototransduction_Homo sapiens_hsa04744 | 0.75080014 |
| 51 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.75007544 |
| 52 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.74157829 |
| 53 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.68104907 |
| 54 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66685371 |
| 55 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.66644515 |
| 56 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.65991051 |
| 57 | Viral myocarditis_Homo sapiens_hsa05416 | 0.65658947 |
| 58 | Allograft rejection_Homo sapiens_hsa05330 | 0.65433453 |
| 59 | Purine metabolism_Homo sapiens_hsa00230 | 0.65142527 |
| 60 | Huntingtons disease_Homo sapiens_hsa05016 | 0.65078954 |
| 61 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.65045223 |
| 62 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.64947463 |
| 63 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.64596201 |
| 64 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.64410142 |
| 65 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.63794557 |
| 66 | Long-term potentiation_Homo sapiens_hsa04720 | 0.63491762 |
| 67 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.62976741 |
| 68 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.62814854 |
| 69 | Hepatitis B_Homo sapiens_hsa05161 | 0.62489521 |
| 70 | Lysine degradation_Homo sapiens_hsa00310 | 0.62290876 |
| 71 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61991267 |
| 72 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.61535786 |
| 73 | Leishmaniasis_Homo sapiens_hsa05140 | 0.61359797 |
| 74 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.60029793 |
| 75 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.59739685 |
| 76 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.59340295 |
| 77 | Influenza A_Homo sapiens_hsa05164 | 0.58813569 |
| 78 | Adherens junction_Homo sapiens_hsa04520 | 0.58313665 |
| 79 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.58243953 |
| 80 | Pathways in cancer_Homo sapiens_hsa05200 | 0.57612149 |
| 81 | Thyroid cancer_Homo sapiens_hsa05216 | 0.56535682 |
| 82 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.56505311 |
| 83 | Axon guidance_Homo sapiens_hsa04360 | 0.56349228 |
| 84 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.54928075 |
| 85 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.54194871 |
| 86 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.53447837 |
| 87 | Nicotine addiction_Homo sapiens_hsa05033 | 0.53409363 |
| 88 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.53001041 |
| 89 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.51595224 |
| 90 | Apoptosis_Homo sapiens_hsa04210 | 0.51445513 |
| 91 | Endometrial cancer_Homo sapiens_hsa05213 | 0.51361647 |
| 92 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.50931234 |
| 93 | Melanoma_Homo sapiens_hsa05218 | 0.49768590 |
| 94 | Colorectal cancer_Homo sapiens_hsa05210 | 0.49450443 |
| 95 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.49390210 |
| 96 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.48260219 |
| 97 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.48134825 |
| 98 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.48097347 |
| 99 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.48037223 |
| 100 | Taste transduction_Homo sapiens_hsa04742 | 0.48005751 |
| 101 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.47971459 |
| 102 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.47873095 |
| 103 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.46196921 |
| 104 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.46166511 |
| 105 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.45242522 |
| 106 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.45160263 |
| 107 | Hepatitis C_Homo sapiens_hsa05160 | 0.44781679 |
| 108 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.43447233 |
| 109 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.43151187 |
| 110 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.42354720 |
| 111 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.39676881 |
| 112 | Platelet activation_Homo sapiens_hsa04611 | 0.39067366 |
| 113 | Parkinsons disease_Homo sapiens_hsa05012 | 0.34842509 |
| 114 | Tight junction_Homo sapiens_hsa04530 | 0.33278754 |
| 115 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.31725678 |
| 116 | Olfactory transduction_Homo sapiens_hsa04740 | 0.30972379 |
| 117 | Circadian rhythm_Homo sapiens_hsa04710 | 0.25248502 |
| 118 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.23977389 |
| 119 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.23382579 |
| 120 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.23259903 |
| 121 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.23212899 |
| 122 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.19333776 |
| 123 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.17277565 |
| 124 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.16146588 |
| 125 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.11802064 |
| 126 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.11058690 |

