SLX1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.19337450
2negative regulation of B cell apoptotic process (GO:0002903)4.05116560
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.87640678
4immunoglobulin mediated immune response (GO:0016064)3.77974688
5GDP-mannose metabolic process (GO:0019673)3.71246151
6NIK/NF-kappaB signaling (GO:0038061)3.70957502
7purine deoxyribonucleotide catabolic process (GO:0009155)3.57920114
8deoxyribonucleotide catabolic process (GO:0009264)3.49527005
9antigen processing and presentation of endogenous antigen (GO:0019883)3.38760637
10positive regulation of gamma-delta T cell activation (GO:0046645)3.35964186
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35467054
12iron-sulfur cluster assembly (GO:0016226)3.31297757
13metallo-sulfur cluster assembly (GO:0031163)3.31297757
14deoxyribose phosphate catabolic process (GO:0046386)3.29877873
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24009849
16pyrimidine nucleotide catabolic process (GO:0006244)3.23311245
17regulation of B cell apoptotic process (GO:0002902)3.09518120
18positive thymic T cell selection (GO:0045059)3.07276292
19positive regulation of B cell differentiation (GO:0045579)3.01979729
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99592501
21Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98013352
22pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93956450
23ribosomal small subunit biogenesis (GO:0042274)2.93588843
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91316670
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90950205
26pentose metabolic process (GO:0019321)2.90416045
27negative regulation of myeloid cell apoptotic process (GO:0033033)2.89632035
28B cell mediated immunity (GO:0019724)2.88194442
29DNA deamination (GO:0045006)2.87732737
30UV protection (GO:0009650)2.87041241
31negative regulation of erythrocyte differentiation (GO:0045647)2.81892425
32positive regulation by symbiont of host defense response (GO:0052509)2.81680569
33modulation by symbiont of host defense response (GO:0052031)2.81680569
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81680569
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81680569
36positive regulation by organism of defense response of other organism involved in symbiotic interact2.81680569
37modulation by symbiont of host immune response (GO:0052553)2.81680569
38regulation of monocyte differentiation (GO:0045655)2.81207841
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80649021
40phosphatidylglycerol biosynthetic process (GO:0006655)2.79885572
41nucleotide salvage (GO:0043173)2.76263643
42regulation of mitochondrial translation (GO:0070129)2.73183711
43thymic T cell selection (GO:0045061)2.72463515
44rRNA modification (GO:0000154)2.71226548
45autophagic vacuole fusion (GO:0000046)2.67873943
46cytochrome complex assembly (GO:0017004)2.65781570
47response to peptidoglycan (GO:0032494)2.62678845
48oxidative phosphorylation (GO:0006119)2.61531397
492-deoxyribonucleotide metabolic process (GO:0009394)2.60907970
50protein complex biogenesis (GO:0070271)2.60686327
51regulation of gamma-delta T cell differentiation (GO:0045586)2.60323002
52negative regulation of cell killing (GO:0031342)2.59198332
53negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.59198332
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.58135174
55deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.55667234
56negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.55620744
57mature B cell differentiation involved in immune response (GO:0002313)2.54438735
58positive regulation of T cell mediated cytotoxicity (GO:0001916)2.52018952
59regulation of gamma-delta T cell activation (GO:0046643)2.51810511
60positive regulation of antigen processing and presentation (GO:0002579)2.51454143
61detection of bacterium (GO:0016045)2.51393681
62negative thymic T cell selection (GO:0045060)2.51353199
63base-excision repair, AP site formation (GO:0006285)2.50881575
64mannose metabolic process (GO:0006013)2.48447382
65regulation of antigen processing and presentation (GO:0002577)2.48088665
66purine nucleotide salvage (GO:0032261)2.46536393
67amyloid precursor protein catabolic process (GO:0042987)2.46188833
68response to interferon-beta (GO:0035456)2.43821538
69neutrophil activation involved in immune response (GO:0002283)2.43628643
70pseudouridine synthesis (GO:0001522)2.43359039
71negative regulation of lymphocyte apoptotic process (GO:0070229)2.43012691
72deoxyribose phosphate metabolic process (GO:0019692)2.42309815
73mitochondrial respiratory chain complex assembly (GO:0033108)2.41979545
74negative regulation of DNA-templated transcription, elongation (GO:0032785)2.41853667
75heme biosynthetic process (GO:0006783)2.41007184
76chaperone mediated protein folding requiring cofactor (GO:0051085)2.38518412
77rRNA transcription (GO:0009303)2.38206271
78negative T cell selection (GO:0043383)2.37360863
79negative regulation of innate immune response (GO:0045824)2.37106340
80mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.35180097
81mitochondrial respiratory chain complex I assembly (GO:0032981)2.35180097
82NADH dehydrogenase complex assembly (GO:0010257)2.35180097
83peptidyl-arginine omega-N-methylation (GO:0035247)2.34896648
84purine deoxyribonucleotide metabolic process (GO:0009151)2.34056081
85positive regulation of T cell apoptotic process (GO:0070234)2.32603568
86heme metabolic process (GO:0042168)2.32175017
87regulation of T cell mediated cytotoxicity (GO:0001914)2.31421662
88response to protozoan (GO:0001562)2.31143702
89actin nucleation (GO:0045010)2.30832475
90regulation of interferon-beta biosynthetic process (GO:0045357)2.30695152
91T cell selection (GO:0045058)2.30606690
92negative regulation of phagocytosis (GO:0050765)2.30251127
93negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.30021638
94positive regulation of prostaglandin secretion (GO:0032308)2.28189169
95GTP biosynthetic process (GO:0006183)2.28174773
96pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.27322692
97regulation of mast cell degranulation (GO:0043304)2.26961925
98negative regulation of leukocyte apoptotic process (GO:2000107)2.26953190
99guanosine-containing compound biosynthetic process (GO:1901070)2.26494950
100regulation of B cell differentiation (GO:0045577)2.26225730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human2.88224267
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80478203
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.71965392
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.62340948
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51573322
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29661921
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26005737
8LXR_22292898_ChIP-Seq_THP-1_Human2.25552139
9MYC_22102868_ChIP-Seq_BL_Human2.23367047
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11134062
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04909695
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01095906
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00824264
14BCL6_27268052_Chip-Seq_Bcells_Human1.96236611
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92451575
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90087422
17ELF1_20517297_ChIP-Seq_JURKAT_Human1.87950255
18P68_20966046_ChIP-Seq_HELA_Human1.86550730
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85374340
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84529945
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82674579
22TET1_21451524_ChIP-Seq_MESCs_Mouse1.81620800
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81061044
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80569402
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79870758
26BCOR_27268052_Chip-Seq_Bcells_Human1.72843676
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70122362
28MAF_26560356_Chip-Seq_TH2_Human1.68266768
29UTX_26944678_Chip-Seq_JUKART_Human1.65731306
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63050542
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62648665
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.62551941
33VDR_24763502_ChIP-Seq_THP-1_Human1.60758352
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.59695591
35MAF_26560356_Chip-Seq_TH1_Human1.58590484
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57175463
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55930581
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.52853426
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52315399
40CIITA_25753668_ChIP-Seq_RAJI_Human1.52004551
41SA1_27219007_Chip-Seq_ERYTHROID_Human1.47322219
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46106738
43XRN2_22483619_ChIP-Seq_HELA_Human1.45739689
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45412947
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43866817
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43711900
47GABP_19822575_ChIP-Seq_HepG2_Human1.43370998
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40831139
49E2F1_20622854_ChIP-Seq_HELA_Human1.37829072
50PHF8_20622854_ChIP-Seq_HELA_Human1.37485518
51CTCF_26484167_Chip-Seq_Bcells_Mouse1.36554958
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34841757
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34350502
54SPI1_23547873_ChIP-Seq_NB4_Human1.34129711
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33896621
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33457098
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.33256600
58RACK7_27058665_Chip-Seq_MCF-7_Human1.32626800
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31324436
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31228402
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31152251
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.29894940
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28270228
64KDM2B_26808549_Chip-Seq_DND41_Human1.27832392
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27608341
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.27559792
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.27428831
68SCL_19346495_ChIP-Seq_HPC-7_Human1.27185643
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27000235
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25106955
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24828392
72CTCF_21964334_Chip-Seq_Bcells_Human1.24635989
73* FOXP1_21924763_ChIP-Seq_HESCs_Human1.24421183
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.23723561
75ZNF263_19887448_ChIP-Seq_K562_Human1.23162621
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21614683
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20754075
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20080177
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18822410
80CTCF_20526341_ChIP-Seq_ESCs_Human1.18759008
81DCP1A_22483619_ChIP-Seq_HELA_Human1.18653917
82SA1_27219007_Chip-Seq_Bcells_Human1.17833721
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17636574
84MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16381944
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16199382
86SMC4_20622854_ChIP-Seq_HELA_Human1.15880176
87P300_27268052_Chip-Seq_Bcells_Human1.15552438
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15356678
89CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14999905
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14956383
91TCF7_22412390_ChIP-Seq_EML_Mouse1.14567626
92FOXP3_21729870_ChIP-Seq_TREG_Human1.11620396
93RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11308395
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10274692
95ETS1_21867929_ChIP-Seq_TH2_Mouse1.08303405
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05835874
97KDM5A_27292631_Chip-Seq_BREAST_Human1.05587056
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05504770
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05428505
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05017249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.37309509
2MP0003806_abnormal_nucleotide_metabolis3.07869567
3MP0005058_abnormal_lysosome_morphology3.03815701
4MP0005671_abnormal_response_to2.99241876
5MP0001835_abnormal_antigen_presentation2.89935056
6MP0002132_abnormal_respiratory_system2.73475676
7MP0005025_abnormal_response_to2.57337587
8MP0009333_abnormal_splenocyte_physiolog2.55394861
9MP0003763_abnormal_thymus_physiology2.52683526
10MP0000685_abnormal_immune_system2.44397941
11MP0005000_abnormal_immune_tolerance2.44191510
12MP0001800_abnormal_humoral_immune2.35828560
13MP0002723_abnormal_immune_serum2.21298395
14MP0009785_altered_susceptibility_to2.20723530
15MP0001873_stomach_inflammation2.17364421
16MP0002420_abnormal_adaptive_immunity2.14752867
17MP0002419_abnormal_innate_immunity2.13275003
18MP0001819_abnormal_immune_cell2.13113611
19MP0002148_abnormal_hypersensitivity_rea2.13071298
20MP0005397_hematopoietic_system_phenotyp2.10047823
21MP0001545_abnormal_hematopoietic_system2.10047823
22MP0009278_abnormal_bone_marrow2.09281907
23MP0002452_abnormal_antigen_presenting2.05686621
24MP0001790_abnormal_immune_system2.02125030
25MP0005387_immune_system_phenotype2.02125030
26MP0005464_abnormal_platelet_physiology1.97722597
27MP0003303_peritoneal_inflammation1.91779877
28MP0005451_abnormal_body_composition1.90595126
29MP0002398_abnormal_bone_marrow1.87640210
30MP0003172_abnormal_lysosome_physiology1.86107784
31MP0006082_CNS_inflammation1.83456293
32MP0006036_abnormal_mitochondrial_physio1.82621086
33MP0003724_increased_susceptibility_to1.80963973
34MP0000465_gastrointestinal_hemorrhage1.79864749
35MP0009840_abnormal_foam_cell1.79384732
36MP0000716_abnormal_immune_system1.77381852
37MP0010155_abnormal_intestine_physiology1.75678705
38MP0003866_abnormal_defecation1.64292692
39MP0002429_abnormal_blood_cell1.63134959
40MP0002722_abnormal_immune_system1.62972217
41MP0000689_abnormal_spleen_morphology1.57505939
42MP0002405_respiratory_system_inflammati1.54650123
43MP0005670_abnormal_white_adipose1.53721503
44MP0002396_abnormal_hematopoietic_system1.53350133
45MP0001845_abnormal_inflammatory_respons1.52185985
46MP0008260_abnormal_autophagy1.50575216
47MP0002254_reproductive_system_inflammat1.47529923
48MP0000703_abnormal_thymus_morphology1.45279833
49MP0000015_abnormal_ear_pigmentation1.42880677
50MP0001533_abnormal_skeleton_physiology1.41853930
51MP0008469_abnormal_protein_level1.36593607
52MP0005360_urolithiasis1.36004117
53MP0000678_abnormal_parathyroid_gland1.34358574
54MP0003786_premature_aging1.32196954
55MP0005075_abnormal_melanosome_morpholog1.31849895
56MP0001764_abnormal_homeostasis1.30313094
57MP0003693_abnormal_embryo_hatching1.27768241
58MP0005083_abnormal_biliary_tract1.26641585
59MP0004947_skin_inflammation1.25893236
60MP0001853_heart_inflammation1.24499350
61MP0003183_abnormal_peptide_metabolism1.20677005
62MP0000490_abnormal_crypts_of1.17744729
63MP0003191_abnormal_cellular_cholesterol1.15987837
64MP0003186_abnormal_redox_activity1.15364828
65MP0002138_abnormal_hepatobiliary_system1.14436085
66MP0003656_abnormal_erythrocyte_physiolo1.13550035
67MP0000858_altered_metastatic_potential1.11775715
68MP0001663_abnormal_digestive_system1.11154414
69MP0006035_abnormal_mitochondrial_morpho1.07833093
70MP0009764_decreased_sensitivity_to1.05866571
71MP0002933_joint_inflammation1.05769845
72MP0002019_abnormal_tumor_incidence1.04762247
73MP0005410_abnormal_fertilization1.04181629
74MP0003075_altered_response_to1.00370568
75MP0005166_decreased_susceptibility_to0.97900913
76MP0005310_abnormal_salivary_gland0.97261190
77MP0004381_abnormal_hair_follicle0.95779258
78MP0001849_ear_inflammation0.88818403
79MP0009643_abnormal_urine_homeostasis0.86162618
80MP0003111_abnormal_nucleus_morphology0.84620679
81MP0000681_abnormal_thyroid_gland0.83755764
82MP0005636_abnormal_mineral_homeostasis0.81826260
83MP0000609_abnormal_liver_physiology0.78813095
84MP0005365_abnormal_bile_salt0.78047463
85MP0005319_abnormal_enzyme/_coenzyme0.76202474
86MP0005381_digestive/alimentary_phenotyp0.76136671
87MP0009763_increased_sensitivity_to0.74923887
88MP0000313_abnormal_cell_death0.74435195
89MP0005584_abnormal_enzyme/coenzyme_acti0.74239661
90MP0004147_increased_porphyrin_level0.74183392
91MP0008875_abnormal_xenobiotic_pharmacok0.73608047
92MP0002970_abnormal_white_adipose0.68236961
93MP0002653_abnormal_ependyma_morphology0.65879216
94MP0002822_catalepsy0.65395094
95MP0008873_increased_physiological_sensi0.63320463
96MP0000343_altered_response_to0.62756796
97MP0008995_early_reproductive_senescence0.62465769
98MP0010094_abnormal_chromosome_stability0.62063152
99MP0004858_abnormal_nervous_system0.58563838
100MP0002166_altered_tumor_susceptibility0.58126932

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)3.72255975
2Hepatocellular necrosis (HP:0001404)3.63247387
3Recurrent bacterial skin infections (HP:0005406)3.53684694
4Recurrent abscess formation (HP:0002722)3.50530676
5Agammaglobulinemia (HP:0004432)3.37297873
6Increased neuronal autofluorescent lipopigment (HP:0002074)3.35698257
7Elevated erythrocyte sedimentation rate (HP:0003565)3.35396671
8Panhypogammaglobulinemia (HP:0003139)3.30674986
9Chronic obstructive pulmonary disease (HP:0006510)3.16851536
10Obstructive lung disease (HP:0006536)3.16851536
11Cerebral palsy (HP:0100021)3.16380243
12Increased cerebral lipofuscin (HP:0011813)3.16368299
13Recurrent fungal infections (HP:0002841)3.15361368
14Hepatic necrosis (HP:0002605)3.12349525
15Increased serum ferritin (HP:0003281)3.12251303
16Ragged-red muscle fibers (HP:0003200)3.02262591
17Increased muscle lipid content (HP:0009058)2.99215916
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97675182
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97675182
20Eczematoid dermatitis (HP:0000976)2.94118211
21Mediastinal lymphadenopathy (HP:0100721)2.91831202
22Abnormality of the heme biosynthetic pathway (HP:0010472)2.91070734
23Recurrent viral infections (HP:0004429)2.82317879
24Mitochondrial inheritance (HP:0001427)2.81983496
25Microvesicular hepatic steatosis (HP:0001414)2.81848739
26Colitis (HP:0002583)2.78008769
27Meningitis (HP:0001287)2.76071679
28Recurrent cutaneous fungal infections (HP:0011370)2.71446007
29Chronic mucocutaneous candidiasis (HP:0002728)2.71446007
30Abnormality of macrophages (HP:0004311)2.68914736
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.67688264
32Gastrointestinal inflammation (HP:0004386)2.66689397
33Abnormal mitochondria in muscle tissue (HP:0008316)2.65908217
34Increased intramyocellular lipid droplets (HP:0012240)2.65743017
35Abnormality of T cell physiology (HP:0011840)2.61685925
36Myositis (HP:0100614)2.59955466
37Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59151020
38Dicarboxylic aciduria (HP:0003215)2.59151020
39Recurrent skin infections (HP:0001581)2.58671575
40Stomatitis (HP:0010280)2.55200869
41Abnormality of iron homeostasis (HP:0011031)2.54683877
42Purpura (HP:0000979)2.51095522
43Abnormal number of erythroid precursors (HP:0012131)2.49132646
44Inflammation of the large intestine (HP:0002037)2.48663358
45Granulocytopenia (HP:0001913)2.47960955
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.46815017
47Pustule (HP:0200039)2.40216411
48Prolonged bleeding time (HP:0003010)2.39197814
49Hypertensive crisis (HP:0100735)2.37921118
50Increased CSF lactate (HP:0002490)2.37867007
51Increased IgM level (HP:0003496)2.36978913
52Abnormality of T cells (HP:0002843)2.35983634
53Encephalitis (HP:0002383)2.34636330
54Systemic lupus erythematosus (HP:0002725)2.34097409
55Hepatosplenomegaly (HP:0001433)2.28701340
56Severe visual impairment (HP:0001141)2.27842858
57Increased IgE level (HP:0003212)2.24910282
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23687017
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.23417083
60Abnormality of glycolipid metabolism (HP:0010969)2.23417083
61Abnormality of liposaccharide metabolism (HP:0010968)2.23417083
62Dysostosis multiplex (HP:0000943)2.21065786
63Acute encephalopathy (HP:0006846)2.18471763
64Acute necrotizing encephalopathy (HP:0006965)2.17240786
65Cellulitis (HP:0100658)2.16018064
66Abnormality of cells of the erythroid lineage (HP:0012130)2.13240371
67Abnormality of transition element cation homeostasis (HP:0011030)2.09490056
68Lactic acidosis (HP:0003128)2.08590316
69Recurrent gram-negative bacterial infections (HP:0005420)2.07419439
70Acute hepatic failure (HP:0006554)2.05227770
71Epistaxis (HP:0000421)2.04962962
72Urticaria (HP:0001025)2.02796988
73J-shaped sella turcica (HP:0002680)2.02420061
74Emotional lability (HP:0000712)1.98651225
75IgM deficiency (HP:0002850)1.96024291
76Aplastic anemia (HP:0001915)1.95806828
77Reticulocytosis (HP:0001923)1.95254074
78Progressive neurologic deterioration (HP:0002344)1.95005562
79Abnormality of polysaccharide metabolism (HP:0011012)1.94106399
80Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94106399
81Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94106399
82Prolonged neonatal jaundice (HP:0006579)1.93628204
83Increased serum lactate (HP:0002151)1.92887488
84Visual hallucinations (HP:0002367)1.92834477
85Opisthotonus (HP:0002179)1.92411435
86Loss of speech (HP:0002371)1.90905072
87Seborrheic dermatitis (HP:0001051)1.89380466
88Skin rash (HP:0000988)1.89108180
89Orchitis (HP:0100796)1.84303113
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83845654
91Hypergammaglobulinemia (HP:0010702)1.83754554
92Type I transferrin isoform profile (HP:0003642)1.82762402
93Vasculitis (HP:0002633)1.82298013
94Lymphopenia (HP:0001888)1.82285751
95Stridor (HP:0010307)1.81990664
96Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80957767
97Gastrointestinal stroma tumor (HP:0100723)1.80174647
98Neutropenia (HP:0001875)1.79995836
99IgG deficiency (HP:0004315)1.76970169
100Vacuolated lymphocytes (HP:0001922)1.76451295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.73444213
2ERN13.57614205
3VRK23.56431589
4TESK23.39804010
5MAP4K13.15426827
6BCKDK3.09676476
7PIM22.95204682
8MAP3K112.92094780
9KDR2.80832955
10SMG12.32054591
11TESK12.27939460
12GRK62.04258572
13TLK11.80720223
14MAP2K31.72593648
15TBK11.69915288
16TNK21.63932978
17IRAK31.61480997
18BLK1.60080614
19TRIB31.57071624
20TYK21.53805506
21IKBKB1.51213657
22SIK11.48043859
23SCYL21.43715708
24ARAF1.35099241
25TXK1.33551068
26STK161.31605843
27ZAK1.30809958
28IRAK41.28147353
29BTK1.25224704
30VRK11.20108674
31IKBKE1.19596624
32ZAP701.16092710
33JAK31.12397659
34ABL21.10683872
35MAP4K21.09834713
36RIPK41.09580543
37FES1.07516982
38MAP2K21.07375410
39SYK1.03344613
40MAP3K130.96297989
41ITK0.93769478
42AURKA0.88409091
43TAOK20.87873718
44MAP3K30.87709766
45MAP3K10.86680244
46MAPK110.81026061
47KIT0.80015783
48MAP2K60.77500093
49LYN0.77438904
50TAOK30.74457599
51MAPKAPK30.73532016
52MARK30.72705451
53LCK0.71014820
54DAPK10.70819173
55DAPK30.70700243
56SIK20.70504303
57RPS6KA50.70406523
58PRPF4B0.68841393
59MAP3K140.68466619
60NME10.67679700
61MATK0.64832970
62CSF1R0.64247820
63CDK40.63877503
64CSNK1G30.60138731
65PRKCQ0.55800076
66RPS6KL10.55092301
67RPS6KC10.55092301
68LRRK20.51952818
69PIM10.50633072
70MST1R0.49968456
71SIK30.49780668
72TAOK10.49561776
73PDPK10.49241279
74CDK70.47457779
75CSK0.47095929
76RPS6KA60.46410154
77MAP3K80.46059043
78HIPK20.45395034
79PRKCI0.45312310
80RPS6KB20.45252333
81RAF10.44563668
82HCK0.44069877
83ILK0.41557481
84EPHA20.41375692
85BUB10.40841888
86NUAK10.40334030
87PRKD30.39935649
88CSNK1A1L0.37734585
89PAK10.37605338
90MUSK0.36700778
91BRAF0.34343144
92PDK10.34339133
93PRKG20.33480692
94MAPK120.33395734
95MAPKAPK20.33368121
96CHUK0.32800219
97ATR0.32618544
98PRKD20.32029277
99TEC0.31291256
100RPS6KA20.29558867

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.20609086
2Primary immunodeficiency_Homo sapiens_hsa053403.37240279
3Allograft rejection_Homo sapiens_hsa053302.71666021
4Graft-versus-host disease_Homo sapiens_hsa053322.57801704
5Other glycan degradation_Homo sapiens_hsa005112.53392504
6Autoimmune thyroid disease_Homo sapiens_hsa053202.52725348
7Base excision repair_Homo sapiens_hsa034102.42082969
8DNA replication_Homo sapiens_hsa030302.35356735
9Ribosome_Homo sapiens_hsa030102.32580868
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.30178980
11Asthma_Homo sapiens_hsa053102.29284650
12Proteasome_Homo sapiens_hsa030502.11979921
13Antigen processing and presentation_Homo sapiens_hsa046122.08614907
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93839906
15Oxidative phosphorylation_Homo sapiens_hsa001901.90635735
16Type I diabetes mellitus_Homo sapiens_hsa049401.88485369
17Systemic lupus erythematosus_Homo sapiens_hsa053221.84350896
18Leishmaniasis_Homo sapiens_hsa051401.71737854
19Parkinsons disease_Homo sapiens_hsa050121.70248054
20Staphylococcus aureus infection_Homo sapiens_hsa051501.67977218
21Pyrimidine metabolism_Homo sapiens_hsa002401.66039609
22Fructose and mannose metabolism_Homo sapiens_hsa000511.52065392
23Sulfur metabolism_Homo sapiens_hsa009201.47823857
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.46617495
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.44814518
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38744630
27Herpes simplex infection_Homo sapiens_hsa051681.35037990
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25135325
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.24900098
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21434608
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20084317
32Viral myocarditis_Homo sapiens_hsa054161.20066148
33Homologous recombination_Homo sapiens_hsa034401.19439840
34Hematopoietic cell lineage_Homo sapiens_hsa046401.17428078
35RNA polymerase_Homo sapiens_hsa030201.17241369
36Rheumatoid arthritis_Homo sapiens_hsa053231.08727032
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08196277
38* Fanconi anemia pathway_Homo sapiens_hsa034601.07978824
39B cell receptor signaling pathway_Homo sapiens_hsa046621.06672834
40Galactose metabolism_Homo sapiens_hsa000521.04665566
41Tuberculosis_Homo sapiens_hsa051521.02553564
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00882245
43Lysosome_Homo sapiens_hsa041420.98991244
44Huntingtons disease_Homo sapiens_hsa050160.96727399
45Osteoclast differentiation_Homo sapiens_hsa043800.96310474
46Spliceosome_Homo sapiens_hsa030400.95445591
47Alzheimers disease_Homo sapiens_hsa050100.94275033
48Pentose phosphate pathway_Homo sapiens_hsa000300.90910720
49Glutathione metabolism_Homo sapiens_hsa004800.90770884
50Acute myeloid leukemia_Homo sapiens_hsa052210.88347753
51Peroxisome_Homo sapiens_hsa041460.87781143
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87588785
53Epstein-Barr virus infection_Homo sapiens_hsa051690.87515639
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87406760
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85524405
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85080074
57Mismatch repair_Homo sapiens_hsa034300.84446443
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84379678
59Influenza A_Homo sapiens_hsa051640.77505649
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.76125673
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75429681
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71900518
63Phenylalanine metabolism_Homo sapiens_hsa003600.71460754
64Arachidonic acid metabolism_Homo sapiens_hsa005900.67955215
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65535181
66Apoptosis_Homo sapiens_hsa042100.63988088
67Pertussis_Homo sapiens_hsa051330.63978969
68Biosynthesis of amino acids_Homo sapiens_hsa012300.63901484
69Vitamin digestion and absorption_Homo sapiens_hsa049770.61754589
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61145857
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.61011345
72Purine metabolism_Homo sapiens_hsa002300.60356789
73One carbon pool by folate_Homo sapiens_hsa006700.59443321
74Fatty acid elongation_Homo sapiens_hsa000620.58982692
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58591037
76Toxoplasmosis_Homo sapiens_hsa051450.58375495
77T cell receptor signaling pathway_Homo sapiens_hsa046600.57639864
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57013322
79Carbon metabolism_Homo sapiens_hsa012000.55073814
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54991035
81Measles_Homo sapiens_hsa051620.54932496
82N-Glycan biosynthesis_Homo sapiens_hsa005100.53351134
83Metabolic pathways_Homo sapiens_hsa011000.52915663
84Phagosome_Homo sapiens_hsa041450.48360417
85HTLV-I infection_Homo sapiens_hsa051660.46816744
86Shigellosis_Homo sapiens_hsa051310.46676149
87Alcoholism_Homo sapiens_hsa050340.46248004
88Bladder cancer_Homo sapiens_hsa052190.46120330
89Legionellosis_Homo sapiens_hsa051340.43863485
90Viral carcinogenesis_Homo sapiens_hsa052030.43747446
91Nucleotide excision repair_Homo sapiens_hsa034200.40840410
92Notch signaling pathway_Homo sapiens_hsa043300.39157983
93Malaria_Homo sapiens_hsa051440.38907975
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37663798
95TNF signaling pathway_Homo sapiens_hsa046680.36025056
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35273823
97Salmonella infection_Homo sapiens_hsa051320.34614728
98Collecting duct acid secretion_Homo sapiens_hsa049660.33169812
99Tyrosine metabolism_Homo sapiens_hsa003500.32306690
100Regulation of autophagy_Homo sapiens_hsa041400.27318344

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