SLX4IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)4.64953671
2neutrophil activation involved in immune response (GO:0002283)4.36342835
3DNA double-strand break processing (GO:0000729)4.12135005
4respiratory chain complex IV assembly (GO:0008535)4.10675615
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03797918
6response to pheromone (GO:0019236)3.91655605
7respiratory burst (GO:0045730)3.87007111
8protein K6-linked ubiquitination (GO:0085020)3.85467137
9negative regulation of DNA-dependent DNA replication (GO:2000104)3.83721937
10DNA deamination (GO:0045006)3.72114022
11replication fork processing (GO:0031297)3.62605789
12platelet dense granule organization (GO:0060155)3.60654938
13cytochrome complex assembly (GO:0017004)3.51881141
14kinetochore organization (GO:0051383)3.48158219
15regulation of metalloenzyme activity (GO:0048552)3.44583639
16synapsis (GO:0007129)3.43827798
17protein complex biogenesis (GO:0070271)3.42605989
18immunoglobulin mediated immune response (GO:0016064)3.38286031
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.37886302
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.37886302
21modulation by symbiont of host immune response (GO:0052553)3.37886302
22positive regulation by symbiont of host defense response (GO:0052509)3.37886302
23modulation by symbiont of host defense response (GO:0052031)3.37886302
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.37886302
25regulation of hexokinase activity (GO:1903299)3.36867507
26regulation of glucokinase activity (GO:0033131)3.36867507
27kinetochore assembly (GO:0051382)3.35558077
28cullin deneddylation (GO:0010388)3.32451166
29lactate metabolic process (GO:0006089)3.23742596
30NIK/NF-kappaB signaling (GO:0038061)3.22658539
31attachment of spindle microtubules to kinetochore (GO:0008608)3.19956743
32mitochondrial respiratory chain complex assembly (GO:0033108)3.17632137
33response to peptidoglycan (GO:0032494)3.17409495
34L-fucose catabolic process (GO:0042355)3.15860762
35fucose catabolic process (GO:0019317)3.15860762
36L-fucose metabolic process (GO:0042354)3.15860762
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.13785211
38NADH dehydrogenase complex assembly (GO:0010257)3.13785211
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13785211
40RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11917818
41inositol phosphate catabolic process (GO:0071545)3.09806948
42neutrophil activation (GO:0042119)3.08159995
43somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.07955590
44isotype switching (GO:0045190)3.07955590
45somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.07955590
46presynaptic membrane assembly (GO:0097105)3.06597399
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06164285
48microtubule depolymerization (GO:0007019)3.05976782
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.05432529
50protein deneddylation (GO:0000338)3.05385847
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04680549
52positive regulation of interferon-alpha production (GO:0032727)3.03585479
53poly(A)+ mRNA export from nucleus (GO:0016973)3.02441719
54granulocyte activation (GO:0036230)3.01925691
55regulation of RIG-I signaling pathway (GO:0039535)3.01037609
56T cell migration (GO:0072678)2.99108925
57recombinational repair (GO:0000725)2.99072818
58superoxide anion generation (GO:0042554)2.97707117
59keratinocyte development (GO:0003334)2.97108027
60double-strand break repair via homologous recombination (GO:0000724)2.96068557
61protein prenylation (GO:0018342)2.95999827
62prenylation (GO:0097354)2.95999827
63mitotic metaphase plate congression (GO:0007080)2.95639407
64CENP-A containing nucleosome assembly (GO:0034080)2.95091201
65regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.90300350
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89930423
67intraciliary transport (GO:0042073)2.86777761
68maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86643057
69protein localization to cilium (GO:0061512)2.85843504
70regulation of interferon-alpha production (GO:0032647)2.85541597
71positive regulation of chemokine biosynthetic process (GO:0045080)2.85053178
72proteasome assembly (GO:0043248)2.83774413
73resolution of meiotic recombination intermediates (GO:0000712)2.83537205
74cellular response to exogenous dsRNA (GO:0071360)2.82523014
75negative regulation of telomere maintenance (GO:0032205)2.82022188
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.81273772
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81273772
78meiotic cell cycle (GO:0051321)2.80496470
79establishment of chromosome localization (GO:0051303)2.80483403
80kidney morphogenesis (GO:0060993)2.79982596
81positive regulation of defense response to virus by host (GO:0002230)2.79967038
82regulation of helicase activity (GO:0051095)2.79720950
83chromatin remodeling at centromere (GO:0031055)2.79348092
84regulation of cilium movement (GO:0003352)2.79272511
85positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.78642112
86defense response to protozoan (GO:0042832)2.78139942
87piRNA metabolic process (GO:0034587)2.76768951
88prostate gland growth (GO:0060736)2.76716008
89B cell mediated immunity (GO:0019724)2.74602736
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73800238
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73546353
92neural tube formation (GO:0001841)2.72160422
93axoneme assembly (GO:0035082)2.71662890
94branched-chain amino acid catabolic process (GO:0009083)2.70748276
95protein K11-linked deubiquitination (GO:0035871)2.69190456
96centriole replication (GO:0007099)2.68668075
97regulation of meiosis I (GO:0060631)2.67748736
98chaperone-mediated protein transport (GO:0072321)2.67712363
99phosphorylated carbohydrate dephosphorylation (GO:0046838)2.67446422
100inositol phosphate dephosphorylation (GO:0046855)2.67446422
101DNA catabolic process, exonucleolytic (GO:0000738)2.66179921
102monocyte chemotaxis (GO:0002548)2.66043346
103meiotic chromosome segregation (GO:0045132)2.65955353
104hydrogen peroxide biosynthetic process (GO:0050665)2.63560767
105regulation of activation of Janus kinase activity (GO:0010533)2.63133811
106metaphase plate congression (GO:0051310)2.63047896
107histone H2A acetylation (GO:0043968)2.62620381
108protein neddylation (GO:0045116)2.61901559
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61736644
110regulation of mitotic spindle checkpoint (GO:1903504)2.61736644
111reactive oxygen species biosynthetic process (GO:1903409)2.60577674
112negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.60445489
113regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.60215601
114mismatch repair (GO:0006298)2.59650164
115polyol catabolic process (GO:0046174)2.59577710
116eosinophil chemotaxis (GO:0048245)2.58634003
117negative regulation by host of viral transcription (GO:0043922)2.58536059
118positive regulation of interferon-beta production (GO:0032728)2.58390306
119presynaptic membrane organization (GO:0097090)2.57619154
120cellular ketone body metabolic process (GO:0046950)2.57088839
121pyrimidine nucleobase catabolic process (GO:0006208)2.56928505
122negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56872182
123negative regulation of translation, ncRNA-mediated (GO:0040033)2.56872182
124regulation of translation, ncRNA-mediated (GO:0045974)2.56872182
125positive regulation of alpha-beta T cell proliferation (GO:0046641)2.56671863
126protein polyglutamylation (GO:0018095)2.55815076
127mitotic chromosome condensation (GO:0007076)2.55763246
128DNA replication checkpoint (GO:0000076)2.55748325
129positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.55008889
130positive regulation of interleukin-1 beta secretion (GO:0050718)2.54895423
131cilium morphogenesis (GO:0060271)2.54490702
132DNA replication-independent nucleosome assembly (GO:0006336)2.54359917
133DNA replication-independent nucleosome organization (GO:0034724)2.54359917
134histone exchange (GO:0043486)2.53805946
135regulation of telomere maintenance (GO:0032204)2.53439232
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52335745
137tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52335745
138dopamine transport (GO:0015872)2.52059090
139DNA replication-dependent nucleosome organization (GO:0034723)2.50936305
140DNA replication-dependent nucleosome assembly (GO:0006335)2.50936305
141regulation of T-helper 1 cell differentiation (GO:0045625)2.50568058
142protein localization to chromosome, centromeric region (GO:0071459)2.48587215
143regulation of fever generation (GO:0031620)2.48131561
144limb bud formation (GO:0060174)2.47244940
145preassembly of GPI anchor in ER membrane (GO:0016254)2.46708156
146leukocyte aggregation (GO:0070486)2.46348457
147negative regulation of neurological system process (GO:0031645)2.46236914
148mast cell activation (GO:0045576)2.46177597
149DNA methylation involved in gamete generation (GO:0043046)2.45818542
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.45132868
151GPI anchor metabolic process (GO:0006505)2.43697343
152myeloid cell activation involved in immune response (GO:0002275)2.42858059
153photoreceptor cell maintenance (GO:0045494)2.42679895
154regulation of double-strand break repair via homologous recombination (GO:0010569)2.42537305
155negative regulation of viral genome replication (GO:0045071)2.40957998
156regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.40932092
157signal peptide processing (GO:0006465)2.40547459
158epithelial cilium movement (GO:0003351)2.40462705
159type I interferon signaling pathway (GO:0060337)2.40243400
160cellular response to type I interferon (GO:0071357)2.40243400
161monoubiquitinated protein deubiquitination (GO:0035520)2.39820777
162regulation of chemokine biosynthetic process (GO:0045073)2.39353427
163interferon-gamma-mediated signaling pathway (GO:0060333)2.39246754
164response to host (GO:0075136)2.39179633
165response to host defenses (GO:0052200)2.39179633
166response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.39179633
167response to muramyl dipeptide (GO:0032495)2.39091722
168transepithelial transport (GO:0070633)2.38972471
169reciprocal DNA recombination (GO:0035825)2.38089081
170reciprocal meiotic recombination (GO:0007131)2.38089081
171nonmotile primary cilium assembly (GO:0035058)2.37888844
172positive regulation of interleukin-17 production (GO:0032740)2.37794911
173negative regulation of nitric oxide biosynthetic process (GO:0045019)2.37642629
174response to protozoan (GO:0001562)2.37353356
175mannosylation (GO:0097502)2.37210353
176somatic diversification of immunoglobulins (GO:0016445)2.37198036
177organelle disassembly (GO:1903008)2.36745017
178single strand break repair (GO:0000012)2.35676344
179C-terminal protein lipidation (GO:0006501)2.35477607
180postreplication repair (GO:0006301)2.35075535
181lymphocyte chemotaxis (GO:0048247)2.35033466
182cellular response to interferon-beta (GO:0035458)2.34939925
183response to type I interferon (GO:0034340)2.34187423
184lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33905510
185antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.33355797
186positive regulation of interleukin-1 beta production (GO:0032731)2.33037555
187positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.32797230
188mitotic sister chromatid cohesion (GO:0007064)2.32700005
189negative regulation of myeloid cell apoptotic process (GO:0033033)2.31790135
190regulation of prostaglandin secretion (GO:0032306)2.30069053
191regulation of mononuclear cell migration (GO:0071675)2.29082046
192leukocyte degranulation (GO:0043299)2.28986454
193spindle checkpoint (GO:0031577)2.28771114
194positive regulation of interleukin-1 secretion (GO:0050716)2.28562176
195centriole assembly (GO:0098534)2.28277365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.13321471
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.65310086
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.93096947
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45822922
5ZNF274_21170338_ChIP-Seq_K562_Hela3.23963901
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19163790
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.16911224
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.04858751
9VDR_22108803_ChIP-Seq_LS180_Human2.83933351
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82303987
11GBX2_23144817_ChIP-Seq_PC3_Human2.78714703
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.72947402
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63379834
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61908284
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61087814
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54753888
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.49113329
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.40876062
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23273539
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.17756613
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.17454911
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13980433
23ELK1_19687146_ChIP-ChIP_HELA_Human2.10728557
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09451171
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99989564
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91692577
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91619997
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.84591047
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80375077
30IGF1R_20145208_ChIP-Seq_DFB_Human1.79805015
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77810092
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76066603
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.75154713
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71883882
35VDR_23849224_ChIP-Seq_CD4+_Human1.71463969
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70779102
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69925588
38* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69592246
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69094250
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67576146
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66993756
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66000176
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61620764
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.57294724
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56939697
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53545649
47TAF15_26573619_Chip-Seq_HEK293_Human1.53541669
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53412219
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.53321448
50BCAT_22108803_ChIP-Seq_LS180_Human1.53277413
51ER_23166858_ChIP-Seq_MCF-7_Human1.52831271
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51916352
53SPI1_23547873_ChIP-Seq_NB4_Human1.51787696
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51478581
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51288571
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50412414
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47646165
58FUS_26573619_Chip-Seq_HEK293_Human1.47135953
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47042802
60SMAD4_21799915_ChIP-Seq_A2780_Human1.46216912
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.43588912
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42552709
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.42513633
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42417479
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42277506
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41998284
67CBP_20019798_ChIP-Seq_JUKART_Human1.41967013
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41967013
69EWS_26573619_Chip-Seq_HEK293_Human1.41472675
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41248290
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39509420
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39186771
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37687318
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37217246
75NANOG_19829295_ChIP-Seq_ESCs_Human1.36657223
76SOX2_19829295_ChIP-Seq_ESCs_Human1.36657223
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36480408
78AR_25329375_ChIP-Seq_VCAP_Human1.36447432
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36430842
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.34437201
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31604645
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31593580
83TCF4_22108803_ChIP-Seq_LS180_Human1.31404848
84STAT3_23295773_ChIP-Seq_U87_Human1.30697182
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29253190
86TCF4_23295773_ChIP-Seq_U87_Human1.29038985
87TP53_22573176_ChIP-Seq_HFKS_Human1.27561733
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27429267
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26797991
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24160616
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23785121
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22646009
93MYC_18940864_ChIP-ChIP_HL60_Human1.22362252
94JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20423311
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19667424
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19060022
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17235104
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.16656060
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16519505
100FOXP3_21729870_ChIP-Seq_TREG_Human1.16311268
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.16039144
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15976471
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14961127
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.14744569
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14744569
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14018329
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12375124
108MYB_26560356_Chip-Seq_TH2_Human1.12038502
109IRF1_19129219_ChIP-ChIP_H3396_Human1.11159272
110RUNX2_22187159_ChIP-Seq_PCA_Human1.10475678
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.09679000
112SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09353524
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09111216
114NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09038843
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08698805
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08609456
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08455002
118CDX2_22108803_ChIP-Seq_LS180_Human1.08445738
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08030532
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07965159
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.07642569
122ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07428915
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07345180
124MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05406447
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.04633174
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03695055
127P53_22387025_ChIP-Seq_ESCs_Mouse1.02533462
128FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02013182
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.01925891
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01862102
131ETS1_20019798_ChIP-Seq_JURKAT_Human1.01535730
132NMYC_18555785_Chip-Seq_ESCs_Mouse1.00328286
133SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00217629
134STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99815228
135NFE2_27457419_Chip-Seq_LIVER_Mouse0.99521186
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99087674
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.97930431
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97592963
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.95317209
140RNF2_27304074_Chip-Seq_NSC_Mouse0.93889334
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93491684
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93225995
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.92305919
144P300_18555785_Chip-Seq_ESCs_Mouse0.91151706
145YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89905307
146SRF_21415370_ChIP-Seq_HL-1_Mouse0.88912478
147SOX2_18555785_Chip-Seq_ESCs_Mouse0.88673238
148ZFX_18555785_Chip-Seq_ESCs_Mouse0.87502294
149MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87197196
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86980024
151DCP1A_22483619_ChIP-Seq_HELA_Human0.86156219
152OCT4_18555785_Chip-Seq_ESCs_Mouse0.85872013
153P300_19829295_ChIP-Seq_ESCs_Human0.85788723
154JUN_21703547_ChIP-Seq_K562_Human0.81320133
155SMAD1_18555785_Chip-Seq_ESCs_Mouse0.81242635
156MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78742021
157VDR_24787735_ChIP-Seq_THP-1_Human0.77654443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.80240966
2MP0009785_altered_susceptibility_to3.45726081
3MP0001835_abnormal_antigen_presentation3.18259120
4MP0008057_abnormal_DNA_replication3.16895244
5MP0003950_abnormal_plasma_membrane3.14241877
6MP0005671_abnormal_response_to2.93796452
7MP0002148_abnormal_hypersensitivity_rea2.58673398
8MP0010094_abnormal_chromosome_stability2.56213865
9MP0005000_abnormal_immune_tolerance2.43446293
10MP0003693_abnormal_embryo_hatching2.31554203
11MP0002837_dystrophic_cardiac_calcinosis2.30621121
12MP0006072_abnormal_retinal_apoptosis2.28324775
13MP0005367_renal/urinary_system_phenotyp2.24658645
14MP0000516_abnormal_urinary_system2.24658645
15MP0002419_abnormal_innate_immunity2.22535380
16MP0003283_abnormal_digestive_organ2.17258721
17MP0003077_abnormal_cell_cycle2.12415641
18MP0005025_abnormal_response_to2.10279194
19MP0010352_gastrointestinal_tract_polyps2.06162387
20MP0002452_abnormal_antigen_presenting2.03875164
21MP0001853_heart_inflammation1.99180589
22MP0008007_abnormal_cellular_replicative1.98825050
23MP0008877_abnormal_DNA_methylation1.96781854
24MP0003303_peritoneal_inflammation1.93835558
25MP0003880_abnormal_central_pattern1.93827136
26MP0008058_abnormal_DNA_repair1.92664311
27MP0006292_abnormal_olfactory_placode1.90507266
28MP0001800_abnormal_humoral_immune1.90439504
29MP0005551_abnormal_eye_electrophysiolog1.88641755
30MP0003724_increased_susceptibility_to1.87923519
31MP0002723_abnormal_immune_serum1.87272451
32MP0002736_abnormal_nociception_after1.83983263
33MP0000685_abnormal_immune_system1.83151330
34MP0006082_CNS_inflammation1.82226839
35MP0001790_abnormal_immune_system1.81060241
36MP0005387_immune_system_phenotype1.81060241
37MP0003121_genomic_imprinting1.81022405
38MP0002006_tumorigenesis1.78229340
39MP0005645_abnormal_hypothalamus_physiol1.77041340
40MP0001819_abnormal_immune_cell1.76656038
41MP0003436_decreased_susceptibility_to1.76355807
42MP0003122_maternal_imprinting1.75913741
43MP0002277_abnormal_respiratory_mucosa1.75595553
44MP0002420_abnormal_adaptive_immunity1.74207246
45MP0001968_abnormal_touch/_nociception1.71578985
46MP0003763_abnormal_thymus_physiology1.70158829
47MP0003123_paternal_imprinting1.69022515
48MP0003111_abnormal_nucleus_morphology1.68517518
49MP0005379_endocrine/exocrine_gland_phen1.67088836
50MP0005253_abnormal_eye_physiology1.67068845
51MP0009333_abnormal_splenocyte_physiolog1.66812385
52MP0005084_abnormal_gallbladder_morpholo1.65765793
53MP0005646_abnormal_pituitary_gland1.64311504
54MP0000427_abnormal_hair_cycle1.62417475
55MP0000569_abnormal_digit_pigmentation1.60951372
56MP0003718_maternal_effect1.59660247
57MP0003828_pulmonary_edema1.59000760
58MP0003191_abnormal_cellular_cholesterol1.56495968
59MP0002751_abnormal_autonomic_nervous1.53114933
60MP0002405_respiratory_system_inflammati1.52515874
61MP0002398_abnormal_bone_marrow1.50953678
62MP0004510_myositis1.50313790
63MP0008872_abnormal_physiological_respon1.48898515
64MP0000372_irregular_coat_pigmentation1.48591501
65MP0002160_abnormal_reproductive_system1.48176490
66MP0005310_abnormal_salivary_gland1.47717732
67MP0001545_abnormal_hematopoietic_system1.43736351
68MP0005397_hematopoietic_system_phenotyp1.43736351
69MP0003890_abnormal_embryonic-extraembry1.43392082
70MP0001529_abnormal_vocalization1.43272963
71MP0004133_heterotaxia1.41156089
72MP0009046_muscle_twitch1.38220869
73MP0000716_abnormal_immune_system1.36863015
74MP0002138_abnormal_hepatobiliary_system1.35825751
75MP0002102_abnormal_ear_morphology1.35186817
76MP0002876_abnormal_thyroid_physiology1.34374748
77MP0003786_premature_aging1.32170707
78MP0000631_abnormal_neuroendocrine_gland1.32118027
79MP0004043_abnormal_pH_regulation1.31401612
80MP0003448_altered_tumor_morphology1.30821545
81MP0001485_abnormal_pinna_reflex1.29885518
82MP0002332_abnormal_exercise_endurance1.29327984
83MP0010155_abnormal_intestine_physiology1.26946594
84MP0004957_abnormal_blastocyst_morpholog1.26678241
85MP0009780_abnormal_chondrocyte_physiolo1.25441495
86MP0003119_abnormal_digestive_system1.23791277
87MP0000858_altered_metastatic_potential1.23733634
88MP0005075_abnormal_melanosome_morpholog1.20992347
89MP0005389_reproductive_system_phenotype1.19991081
90MP0001845_abnormal_inflammatory_respons1.19071036
91MP0008875_abnormal_xenobiotic_pharmacok1.18418349
92MP0002163_abnormal_gland_morphology1.17971341
93MP0001486_abnormal_startle_reflex1.16156617
94MP0009764_decreased_sensitivity_to1.15943640
95MP0009745_abnormal_behavioral_response1.14428080
96MP0004215_abnormal_myocardial_fiber1.11616947
97MP0005174_abnormal_tail_pigmentation1.11512604
98MP0002429_abnormal_blood_cell1.10943918
99MP0002254_reproductive_system_inflammat1.10775760
100MP0003705_abnormal_hypodermis_morpholog1.10342075
101MP0006035_abnormal_mitochondrial_morpho1.10094431
102MP0003937_abnormal_limbs/digits/tail_de1.09553098
103MP0002272_abnormal_nervous_system1.09197930
104MP0003787_abnormal_imprinting1.08640243
105MP0002928_abnormal_bile_duct1.08584719
106MP0006036_abnormal_mitochondrial_physio1.08376788
107MP0010678_abnormal_skin_adnexa1.06698625
108MP0002234_abnormal_pharynx_morphology1.05369647
109MP0001119_abnormal_female_reproductive1.05039192
110MP0000689_abnormal_spleen_morphology1.04853106
111MP0002722_abnormal_immune_system1.04164065
112MP0005220_abnormal_exocrine_pancreas1.03965026
113MP0002909_abnormal_adrenal_gland1.03595561
114MP0001533_abnormal_skeleton_physiology1.03513154
115MP0005464_abnormal_platelet_physiology1.02348942
116MP0010386_abnormal_urinary_bladder1.00006182
117MP0004142_abnormal_muscle_tone1.00002438
118MP0008995_early_reproductive_senescence0.99554781
119MP0001293_anophthalmia0.99142869
120MP0002396_abnormal_hematopoietic_system0.97722124
121MP0000653_abnormal_sex_gland0.97130081
122MP0000490_abnormal_crypts_of0.96825990
123MP0002210_abnormal_sex_determination0.96598037
124MP0000383_abnormal_hair_follicle0.96338897
125MP0003567_abnormal_fetal_cardiomyocyte0.95861812
126MP0005360_urolithiasis0.95500599
127MP0006054_spinal_hemorrhage0.94870837
128MP0004808_abnormal_hematopoietic_stem0.93684595
129MP0000015_abnormal_ear_pigmentation0.93246016
130MP0001145_abnormal_male_reproductive0.92354520
131MP0009278_abnormal_bone_marrow0.91953882
132MP0009697_abnormal_copulation0.91645835
133MP0000350_abnormal_cell_proliferation0.91446242
134MP0001986_abnormal_taste_sensitivity0.91002512
135MP0003011_delayed_dark_adaptation0.90121152
136MP0010234_abnormal_vibrissa_follicle0.89295002
137MP0000703_abnormal_thymus_morphology0.88682872
138MP0002009_preneoplasia0.87249588
139MP0004885_abnormal_endolymph0.86413005
140MP0002166_altered_tumor_susceptibility0.86406678
141MP0001944_abnormal_pancreas_morphology0.86153515
142MP0002132_abnormal_respiratory_system0.85788533
143MP0005451_abnormal_body_composition0.84800833
144MP0003698_abnormal_male_reproductive0.84367697
145MP0008932_abnormal_embryonic_tissue0.83752755
146MP0002090_abnormal_vision0.82585960
147MP0002877_abnormal_melanocyte_morpholog0.82460174
148MP0001929_abnormal_gametogenesis0.82394093
149MP0000647_abnormal_sebaceous_gland0.82315424
150MP0002938_white_spotting0.82151945
151MP0002557_abnormal_social/conspecific_i0.81925721
152MP0001984_abnormal_olfaction0.81885765
153MP0000613_abnormal_salivary_gland0.80916203
154MP0002233_abnormal_nose_morphology0.80498260
155MP0005332_abnormal_amino_acid0.80194544
156MP0005195_abnormal_posterior_eye0.80105197
157MP0002734_abnormal_mechanical_nocicepti0.79753371
158MP0002693_abnormal_pancreas_physiology0.79607653
159MP0001764_abnormal_homeostasis0.79125564
160MP0002638_abnormal_pupillary_reflex0.79119568
161MP0002019_abnormal_tumor_incidence0.79033481
162MP0003137_abnormal_impulse_conducting0.78800304
163MP0002822_catalepsy0.78306666
164MP0004782_abnormal_surfactant_physiolog0.77441079
165MP0008789_abnormal_olfactory_epithelium0.77412729
166MP0008775_abnormal_heart_ventricle0.77164111
167MP0008260_abnormal_autophagy0.76315967
168MP0003315_abnormal_perineum_morphology0.75104599
169MP0005171_absent_coat_pigmentation0.74730218
170MP0005164_abnormal_response_to0.74467968
171MP0008469_abnormal_protein_level0.73974129
172MP0010307_abnormal_tumor_latency0.73837589
173MP0006276_abnormal_autonomic_nervous0.72327610

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.29938503
2Recurrent bacterial skin infections (HP:0005406)5.03891460
3Optic neuritis (HP:0100653)4.42384386
4Retrobulbar optic neuritis (HP:0100654)4.42384386
5Myositis (HP:0100614)4.42282098
6Eczematoid dermatitis (HP:0000976)4.11408536
7Xerostomia (HP:0000217)3.91493684
8Recurrent gram-negative bacterial infections (HP:0005420)3.67917948
9Orchitis (HP:0100796)3.67135576
10Birth length less than 3rd percentile (HP:0003561)3.62434475
11Mediastinal lymphadenopathy (HP:0100721)3.49407221
12Pancreatic cysts (HP:0001737)3.48055319
13Abnormality of the labia minora (HP:0012880)3.29455112
14Methylmalonic acidemia (HP:0002912)3.18857938
15Pulmonary infiltrates (HP:0002113)3.17544873
16True hermaphroditism (HP:0010459)3.16876060
17Pancreatic fibrosis (HP:0100732)3.13367029
18Abnormality of midbrain morphology (HP:0002418)3.11038750
19Molar tooth sign on MRI (HP:0002419)3.11038750
20Chromsome breakage (HP:0040012)3.07290416
21Keratoconjunctivitis sicca (HP:0001097)3.04925088
22Hypothermia (HP:0002045)3.04768857
23Abnormal hair whorl (HP:0010721)2.96350840
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92572920
25Progressive macrocephaly (HP:0004481)2.92242665
26Medial flaring of the eyebrow (HP:0010747)2.89105045
27Obstructive lung disease (HP:0006536)2.87083657
28Chronic obstructive pulmonary disease (HP:0006510)2.87083657
29Keratoconjunctivitis (HP:0001096)2.84997078
30Nephronophthisis (HP:0000090)2.78033698
31Vasculitis (HP:0002633)2.75854738
32Acute necrotizing encephalopathy (HP:0006965)2.75083896
33Fair hair (HP:0002286)2.73266569
34Recurrent skin infections (HP:0001581)2.73227173
35Increased IgM level (HP:0003496)2.68325954
36Recurrent pneumonia (HP:0006532)2.67632940
37Hypertensive crisis (HP:0100735)2.65180576
38Acute encephalopathy (HP:0006846)2.60884504
39Elevated erythrocyte sedimentation rate (HP:0003565)2.58612706
40Methylmalonic aciduria (HP:0012120)2.58591601
41Pulmonary fibrosis (HP:0002206)2.55393397
42Breast hypoplasia (HP:0003187)2.51103769
43Increased CSF lactate (HP:0002490)2.50312302
44Agnosia (HP:0010524)2.48620377
45Gingivitis (HP:0000230)2.48082689
46Abnormality of macrophages (HP:0004311)2.46234793
47Basal ganglia calcification (HP:0002135)2.45829055
48Mitochondrial inheritance (HP:0001427)2.44459338
49Neoplasm of the adrenal cortex (HP:0100641)2.43687773
50Hyperglycinemia (HP:0002154)2.41379740
51Abolished electroretinogram (ERG) (HP:0000550)2.40711236
52Abnormality of the renal medulla (HP:0100957)2.35864873
53Pendular nystagmus (HP:0012043)2.35695292
54Volvulus (HP:0002580)2.35537161
55Abnormality of chromosome stability (HP:0003220)2.31858192
56Encephalitis (HP:0002383)2.30043767
57Abnormality of vitamin B metabolism (HP:0004340)2.26723127
58Hypoglycemic seizures (HP:0002173)2.26031243
59Recurrent fungal infections (HP:0002841)2.25912623
60Ependymoma (HP:0002888)2.25846218
61Intestinal atresia (HP:0011100)2.25539429
62Prostate neoplasm (HP:0100787)2.25223836
63Abnormality of the renal cortex (HP:0011035)2.24919171
64Gait imbalance (HP:0002141)2.23167731
65Congenital primary aphakia (HP:0007707)2.22960228
66Generalized hypopigmentation of hair (HP:0011358)2.19663760
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19163795
68Recurrent viral infections (HP:0004429)2.19080737
69Abnormal mitochondria in muscle tissue (HP:0008316)2.19069981
70Aplasia/Hypoplasia of the uvula (HP:0010293)2.18300554
71Hypomagnesemia (HP:0002917)2.17924373
72Glomerulopathy (HP:0100820)2.17807688
73Hepatosplenomegaly (HP:0001433)2.16818441
74Hyperinsulinemic hypoglycemia (HP:0000825)2.16108206
75Hemoptysis (HP:0002105)2.13414106
76Bone marrow hypocellularity (HP:0005528)2.12140459
77Autoimmune thrombocytopenia (HP:0001973)2.12098402
78Stomatitis (HP:0010280)2.10983015
79Genital tract atresia (HP:0001827)2.10317951
80Ketoacidosis (HP:0001993)2.08489067
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.08398341
82Thyroiditis (HP:0100646)2.08334203
83Pustule (HP:0200039)2.07490456
84Meckel diverticulum (HP:0002245)2.06943643
85Neoplasm of the adrenal gland (HP:0100631)2.06880366
86Hypoglycemic coma (HP:0001325)2.06689478
87Meningitis (HP:0001287)2.06671402
88Progressive inability to walk (HP:0002505)2.06127311
89Nephrogenic diabetes insipidus (HP:0009806)2.05301641
90Congenital stationary night blindness (HP:0007642)2.04137597
91Hepatocellular necrosis (HP:0001404)2.03823934
92Chronic otitis media (HP:0000389)2.03099678
93Pancreatic islet-cell hyperplasia (HP:0004510)2.02437304
94Hepatic necrosis (HP:0002605)2.01404876
95Renal cortical cysts (HP:0000803)2.01350267
96Parakeratosis (HP:0001036)2.01316070
97Aplasia/Hypoplasia of the tibia (HP:0005772)2.00567442
98Sclerocornea (HP:0000647)1.98580869
99Astrocytoma (HP:0009592)1.98321212
100Abnormality of the astrocytes (HP:0100707)1.98321212
101Recurrent lower respiratory tract infections (HP:0002783)1.98020217
102Reduced subcutaneous adipose tissue (HP:0003758)1.97854617
103Abnormality of T cell number (HP:0011839)1.97339090
104Vaginal atresia (HP:0000148)1.96930801
105Abnormality of the vitamin B12 metabolism (HP:0004341)1.95684894
106Colon cancer (HP:0003003)1.94449234
107Abnormality of methionine metabolism (HP:0010901)1.94445759
108Furrowed tongue (HP:0000221)1.94219155
109Leukocytosis (HP:0001974)1.93575792
110Abnormality of the ileum (HP:0001549)1.93563838
111Glioma (HP:0009733)1.93390045
112Male pseudohermaphroditism (HP:0000037)1.92701928
113Lipid accumulation in hepatocytes (HP:0006561)1.92440630
114Protruding tongue (HP:0010808)1.92038765
115Short tibia (HP:0005736)1.91949854
116Abnormality of the pleura (HP:0002103)1.91907565
117Patellar aplasia (HP:0006443)1.91758203
118Myelodysplasia (HP:0002863)1.90406005
119Hematochezia (HP:0002573)1.89221466
120T lymphocytopenia (HP:0005403)1.89020140
121Lymphoma (HP:0002665)1.88429112
122Attenuation of retinal blood vessels (HP:0007843)1.88298581
123Aqueductal stenosis (HP:0002410)1.88167426
124Disproportionate short-trunk short stature (HP:0003521)1.88081415
125IgG deficiency (HP:0004315)1.87938171
126Cerebral edema (HP:0002181)1.87848784
127Papillary thyroid carcinoma (HP:0002895)1.86515271
128Increased hepatocellular lipid droplets (HP:0006565)1.85790778
129Combined immunodeficiency (HP:0005387)1.85579891
130Clubbing of toes (HP:0100760)1.85353019
131Cystic liver disease (HP:0006706)1.85240911
132Nephroblastoma (Wilms tumor) (HP:0002667)1.84443633
133Oligodactyly (hands) (HP:0001180)1.83962064
134Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82591293
135Abnormality of the preputium (HP:0100587)1.82126970
136Abnormality of the metopic suture (HP:0005556)1.82031760
137Gaze-evoked nystagmus (HP:0000640)1.81971966
138Anencephaly (HP:0002323)1.81952404
139Disinhibition (HP:0000734)1.80197608
140Abnormal lung lobation (HP:0002101)1.79713783
141Abnormal drinking behavior (HP:0030082)1.79596605
142Polydipsia (HP:0001959)1.79596605
143Spontaneous hematomas (HP:0007420)1.79342244
144Abnormality of eosinophils (HP:0001879)1.78224668
145Ketosis (HP:0001946)1.77800215
146Cleft eyelid (HP:0000625)1.77378410
147Osteomyelitis (HP:0002754)1.77104056
148Hamartoma of the eye (HP:0010568)1.77038952
149Abnormality of endocrine pancreas physiology (HP:0012093)1.76154027
150Abnormality of the pancreatic islet cells (HP:0006476)1.76154027
151Large for gestational age (HP:0001520)1.75310740
152Postaxial hand polydactyly (HP:0001162)1.75182754
1533-Methylglutaconic aciduria (HP:0003535)1.75060200
154Abnormality of glycine metabolism (HP:0010895)1.74865472
155Abnormality of serine family amino acid metabolism (HP:0010894)1.74865472
156Mucosal telangiectasiae (HP:0100579)1.74619544
157Aplasia/Hypoplasia of the patella (HP:0006498)1.74026506
158Poor head control (HP:0002421)1.74018406
159Abnormality of serum amino acid levels (HP:0003112)1.73920422
160Abnormality of salivation (HP:0100755)1.73557755
161Hypoplasia of the pons (HP:0012110)1.73435718
162Abnormality of incisor morphology (HP:0011063)1.72295431
163Small hand (HP:0200055)1.72284262
164Sloping forehead (HP:0000340)1.72024536
165Hyperglycemia (HP:0003074)1.71663053
166Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71651897
167Abnormal rod and cone electroretinograms (HP:0008323)1.71423885
168Aseptic necrosis (HP:0010885)1.71364842
169Abnormality of the prostate (HP:0008775)1.71151481
170Cellulitis (HP:0100658)1.71120731
171Severe combined immunodeficiency (HP:0004430)1.70854529
172Abnormality of the pons (HP:0007361)1.70830120
173Hyperglycinuria (HP:0003108)1.70710667
174Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70660986
175Short 4th metacarpal (HP:0010044)1.70660986
176Orthostatic hypotension (HP:0001278)1.70627015
177Prominent metopic ridge (HP:0005487)1.70437394
178Aplastic anemia (HP:0001915)1.70216642
179Petechiae (HP:0000967)1.69867740
180Acute myeloid leukemia (HP:0004808)1.69820077
18111 pairs of ribs (HP:0000878)1.69516427
182Inappropriate behavior (HP:0000719)1.69496197
183Broad-based gait (HP:0002136)1.69056687
184Chronic sinusitis (HP:0011109)1.68977067
185Postaxial foot polydactyly (HP:0001830)1.68920367
186Breast carcinoma (HP:0003002)1.68793792
187Increased serum lactate (HP:0002151)1.68754094
188Amaurosis fugax (HP:0100576)1.68715841
189Abnormality of chromosome segregation (HP:0002916)1.67730185
190White forelock (HP:0002211)1.67673197
191Abnormal respiratory epithelium morphology (HP:0012253)1.67380935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.62178162
2MAP3K143.74003318
3TRIM283.17873378
4WNK33.17627055
5RIPK43.03217322
6CDK82.83053537
7SIK32.82052596
8MST42.78024374
9MAP4K22.42612643
10PBK2.40544418
11IRAK42.38363894
12PLK42.24126380
13CDC72.21592916
14BCR2.14419260
15YES11.96121053
16NLK1.95656552
17FGFR21.94386765
18EIF2AK31.92513860
19MELK1.90768029
20BMPR21.87720191
21GRK11.85538991
22TXK1.77799049
23ACVR1B1.75691779
24MAP3K41.73114633
25CLK11.66665593
26KSR11.59267285
27NUAK11.57352523
28BRSK21.53410590
29VRK11.51119543
30STK391.49327875
31STK38L1.49257390
32PINK11.48579643
33TBK11.47773770
34BLK1.47442039
35SIK21.46968949
36SRPK11.45687855
37MARK31.43067739
38JAK31.40764190
39IRAK31.39210118
40WEE11.37073977
41TYK21.35490253
42CDK91.32667716
43CSNK1G11.32020033
44OXSR11.29904928
45PAK31.29616475
46MKNK21.29436659
47BUB11.27806567
48ADRBK21.27399878
49TSSK61.26635371
50INSRR1.24713333
51ZAK1.23415933
52NME21.22153080
53MKNK11.21937067
54CDK41.21566048
55TLK11.20621020
56AKT31.19302966
57IKBKE1.18830806
58KIT1.17990377
59BMPR1B1.17520979
60ERBB31.17359896
61PRPF4B1.13409407
62DYRK21.13041314
63CSNK1G31.10555140
64BRD41.09046181
65STK31.08817886
66CSNK1G21.08679377
67MAP2K71.06590391
68PLK11.06458824
69FER1.05793727
70IKBKB1.00659887
71VRK21.00393335
72MAP3K120.99465925
73EIF2AK20.98510482
74NEK20.97084457
75TRPM70.96441375
76CHUK0.96404540
77CSNK1A1L0.93728709
78MAP4K10.92995181
79CDK120.90034109
80BCKDK0.89805512
81WNK40.88910235
82PRKCE0.88751652
83ERBB40.87934644
84RPS6KA40.84423434
85TTK0.84417775
86ATR0.83942279
87STK40.82203933
88IRAK20.81748935
89PIM10.80617636
90PHKG20.80592336
91PHKG10.80592336
92PLK30.79503084
93PRKCG0.79279962
94CDK30.78790031
95RAF10.78024774
96TGFBR10.76714135
97MATK0.73387349
98CHEK20.71768021
99TNIK0.71631452
100CCNB10.68967044
101ABL20.68366936
102FGR0.67980974
103AURKB0.66291740
104NEK10.64836353
105SYK0.64690248
106BRAF0.63680056
107MAPK130.63045990
108IRAK10.63017942
109EPHA40.62874402
110MAP3K60.62586772
111LYN0.60949695
112MARK10.60418014
113ABL10.57080414
114BRSK10.56694712
115MAP3K130.55830902
116TAF10.55097028
117MAP2K60.54822247
118PLK20.54307428
119PASK0.54193745
120STK160.54170903
121LCK0.53591132
122DYRK30.53539774
123PRKCI0.53115917
124ADRBK10.52970934
125GRK70.50463197
126TAOK30.49284645
127TEC0.48772885
128EPHA30.47564442
129PIM20.47005157
130ATM0.46926025
131FLT30.43551093
132PNCK0.43433161
133CSNK1A10.42959910
134NTRK30.41078353
135CSK0.40987322
136FGFR10.39594744
137LATS10.39251786
138CASK0.39060916
139MINK10.38996853
140ITK0.38545994
141PKN10.37542883
142DAPK20.36295448
143MUSK0.36252702
144HCK0.35773190
145EIF2AK10.35669710
146CAMK2D0.35608461
147PTK2B0.35407466
148CAMK2A0.34755051
149CSNK1D0.33087324
150PRKACA0.32089607
151PRKCQ0.28858147
152CSNK2A10.28746949
153PRKDC0.27452439
154STK110.25002175
155MAP2K40.24772054

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.81726501
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.95496558
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80678267
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.71329664
5Propanoate metabolism_Homo sapiens_hsa006402.58176288
6Allograft rejection_Homo sapiens_hsa053302.51250380
7Proteasome_Homo sapiens_hsa030502.34147688
8Leishmaniasis_Homo sapiens_hsa051402.24986723
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21016189
10Type I diabetes mellitus_Homo sapiens_hsa049402.20656052
11Butanoate metabolism_Homo sapiens_hsa006502.18653356
12RNA polymerase_Homo sapiens_hsa030202.09476015
13Basal transcription factors_Homo sapiens_hsa030222.00906264
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98717584
15Phototransduction_Homo sapiens_hsa047441.95593499
16Homologous recombination_Homo sapiens_hsa034401.95505542
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95099620
18Legionellosis_Homo sapiens_hsa051341.93866426
19DNA replication_Homo sapiens_hsa030301.90252105
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85782833
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85510877
22Vitamin B6 metabolism_Homo sapiens_hsa007501.83714528
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.83609996
24Cell cycle_Homo sapiens_hsa041101.79619989
25Measles_Homo sapiens_hsa051621.68560437
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.67369308
27Protein export_Homo sapiens_hsa030601.67008961
28Selenocompound metabolism_Homo sapiens_hsa004501.66519006
29Mismatch repair_Homo sapiens_hsa034301.65722479
30Hematopoietic cell lineage_Homo sapiens_hsa046401.63811417
31Asthma_Homo sapiens_hsa053101.62244511
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60184893
33Herpes simplex infection_Homo sapiens_hsa051681.58214844
34Caffeine metabolism_Homo sapiens_hsa002321.55308624
35Antigen processing and presentation_Homo sapiens_hsa046121.52888529
36Fanconi anemia pathway_Homo sapiens_hsa034601.50842825
37Non-homologous end-joining_Homo sapiens_hsa034501.50779551
38Rheumatoid arthritis_Homo sapiens_hsa053231.48496931
39Parkinsons disease_Homo sapiens_hsa050121.48325118
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47067656
41Fatty acid elongation_Homo sapiens_hsa000621.46419711
42Tryptophan metabolism_Homo sapiens_hsa003801.43471358
43Sulfur metabolism_Homo sapiens_hsa009201.38741480
44Pertussis_Homo sapiens_hsa051331.37812245
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37012283
46Nucleotide excision repair_Homo sapiens_hsa034201.34491311
47Influenza A_Homo sapiens_hsa051641.33959622
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31796679
49Malaria_Homo sapiens_hsa051441.31259057
50One carbon pool by folate_Homo sapiens_hsa006701.30925116
51RNA degradation_Homo sapiens_hsa030181.28225506
52Pyrimidine metabolism_Homo sapiens_hsa002401.27357902
53Peroxisome_Homo sapiens_hsa041461.27264725
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26740108
55Spliceosome_Homo sapiens_hsa030401.25476959
56Regulation of autophagy_Homo sapiens_hsa041401.24371959
57TNF signaling pathway_Homo sapiens_hsa046681.23519235
58Viral myocarditis_Homo sapiens_hsa054161.22434117
59Autoimmune thyroid disease_Homo sapiens_hsa053201.22003650
60Linoleic acid metabolism_Homo sapiens_hsa005911.20362570
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19810186
62Epstein-Barr virus infection_Homo sapiens_hsa051691.18653639
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18076157
64Osteoclast differentiation_Homo sapiens_hsa043801.17287215
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14907427
66Base excision repair_Homo sapiens_hsa034101.14733959
67Nitrogen metabolism_Homo sapiens_hsa009101.14449440
68Tuberculosis_Homo sapiens_hsa051521.13771409
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10974803
70Primary immunodeficiency_Homo sapiens_hsa053401.09971604
71Salmonella infection_Homo sapiens_hsa051321.07704625
72Hepatitis B_Homo sapiens_hsa051611.06077883
73Phagosome_Homo sapiens_hsa041451.03129516
74Nicotine addiction_Homo sapiens_hsa050331.02168747
75Collecting duct acid secretion_Homo sapiens_hsa049661.01286904
76p53 signaling pathway_Homo sapiens_hsa041150.99673477
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99157798
78Insulin secretion_Homo sapiens_hsa049110.97693513
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96554071
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.95608594
81Pyruvate metabolism_Homo sapiens_hsa006200.93595918
82RNA transport_Homo sapiens_hsa030130.93272588
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93082975
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92381437
85Chemokine signaling pathway_Homo sapiens_hsa040620.89214811
86Alzheimers disease_Homo sapiens_hsa050100.87397867
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87348192
88mRNA surveillance pathway_Homo sapiens_hsa030150.87341851
89Staphylococcus aureus infection_Homo sapiens_hsa051500.86913679
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.86122514
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84526732
92Retinol metabolism_Homo sapiens_hsa008300.83980341
93Fatty acid metabolism_Homo sapiens_hsa012120.83596881
94African trypanosomiasis_Homo sapiens_hsa051430.82391840
95beta-Alanine metabolism_Homo sapiens_hsa004100.82317600
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81942420
97Fatty acid degradation_Homo sapiens_hsa000710.81689804
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80840008
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80761700
100Colorectal cancer_Homo sapiens_hsa052100.79057836
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77634779
102Shigellosis_Homo sapiens_hsa051310.76931480
103Toxoplasmosis_Homo sapiens_hsa051450.75720214
104Metabolic pathways_Homo sapiens_hsa011000.74934692
105Chemical carcinogenesis_Homo sapiens_hsa052040.74720093
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73044956
107T cell receptor signaling pathway_Homo sapiens_hsa046600.71470013
108Pancreatic cancer_Homo sapiens_hsa052120.71049538
109Olfactory transduction_Homo sapiens_hsa047400.70145489
110Folate biosynthesis_Homo sapiens_hsa007900.69430831
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69180051
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.68468105
113Apoptosis_Homo sapiens_hsa042100.67746323
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.67105174
115Taste transduction_Homo sapiens_hsa047420.66689005
116Viral carcinogenesis_Homo sapiens_hsa052030.66611418
117Purine metabolism_Homo sapiens_hsa002300.66494267
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64904048
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64187186
120B cell receptor signaling pathway_Homo sapiens_hsa046620.62924741
121HTLV-I infection_Homo sapiens_hsa051660.62528259
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59891904
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58532849
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58495217
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57537949
126Glutathione metabolism_Homo sapiens_hsa004800.57107643
127Systemic lupus erythematosus_Homo sapiens_hsa053220.55634094
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55541175
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55205094
130Ether lipid metabolism_Homo sapiens_hsa005650.55015412
131MicroRNAs in cancer_Homo sapiens_hsa052060.54758211
132Oocyte meiosis_Homo sapiens_hsa041140.53699313
133ABC transporters_Homo sapiens_hsa020100.53550404
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53288696
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49588654
136Hepatitis C_Homo sapiens_hsa051600.47833554
137Fat digestion and absorption_Homo sapiens_hsa049750.46641360
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46197626
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45510513
140Ribosome_Homo sapiens_hsa030100.44674256
141Circadian rhythm_Homo sapiens_hsa047100.42532735
142Huntingtons disease_Homo sapiens_hsa050160.42231180
143Steroid biosynthesis_Homo sapiens_hsa001000.40326943
144Serotonergic synapse_Homo sapiens_hsa047260.39838741
145Vitamin digestion and absorption_Homo sapiens_hsa049770.39774867
146Leukocyte transendothelial migration_Homo sapiens_hsa046700.38969033
147Dorso-ventral axis formation_Homo sapiens_hsa043200.38000084
148Prostate cancer_Homo sapiens_hsa052150.37682099
149Small cell lung cancer_Homo sapiens_hsa052220.35868310
150N-Glycan biosynthesis_Homo sapiens_hsa005100.34938025
151Arachidonic acid metabolism_Homo sapiens_hsa005900.34743246
152Chronic myeloid leukemia_Homo sapiens_hsa052200.34334556
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33797999
154FoxO signaling pathway_Homo sapiens_hsa040680.32964735
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32789268
156Starch and sucrose metabolism_Homo sapiens_hsa005000.31701585
157Hedgehog signaling pathway_Homo sapiens_hsa043400.31431973
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30709583
159Sphingolipid metabolism_Homo sapiens_hsa006000.30480900
160Dopaminergic synapse_Homo sapiens_hsa047280.29632054
161TGF-beta signaling pathway_Homo sapiens_hsa043500.29612048
162Platelet activation_Homo sapiens_hsa046110.29546960
163Amphetamine addiction_Homo sapiens_hsa050310.29038326
164Circadian entrainment_Homo sapiens_hsa047130.28239163
165Oxidative phosphorylation_Homo sapiens_hsa001900.27448324
166Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26769265
167Sphingolipid signaling pathway_Homo sapiens_hsa040710.24833967
168Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24063579

Most similar genes based on co-expression Upload to Enrichr

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