SMAD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane raft organization (GO:0031579)4.30499511
2axon extension involved in axon guidance (GO:0048846)4.20761809
3neuron projection extension involved in neuron projection guidance (GO:1902284)4.20761809
4lung epithelium development (GO:0060428)3.82956733
5chondrocyte proliferation (GO:0035988)3.78637833
6hemidesmosome assembly (GO:0031581)3.74026190
7hypotonic response (GO:0006971)3.73576076
8mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.66531345
9COPI coating of Golgi vesicle (GO:0048205)3.64176841
10Golgi transport vesicle coating (GO:0048200)3.64176841
11epithelial cell differentiation involved in prostate gland development (GO:0060742)3.55353817
12glucocorticoid receptor signaling pathway (GO:0042921)3.43799222
13desmosome organization (GO:0002934)3.39616421
14lens fiber cell development (GO:0070307)3.38134178
15positive regulation of astrocyte differentiation (GO:0048711)3.31030709
16negative regulation of chondrocyte differentiation (GO:0032331)3.19231415
17positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.16845389
18epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.13141972
19collagen fibril organization (GO:0030199)3.12540970
20embryonic viscerocranium morphogenesis (GO:0048703)3.12461921
21hippo signaling (GO:0035329)3.10102617
22epithelial cell-cell adhesion (GO:0090136)3.08466174
23corticosteroid receptor signaling pathway (GO:0031958)2.99925999
24collecting duct development (GO:0072044)2.98522450
25cell migration involved in heart development (GO:0060973)2.96381335
26basement membrane organization (GO:0071711)2.94014914
27endocardial cushion morphogenesis (GO:0003203)2.92341305
28adherens junction assembly (GO:0034333)2.91954099
29venous blood vessel morphogenesis (GO:0048845)2.90853828
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90524113
31peptidyl-lysine dimethylation (GO:0018027)2.90306552
32muscle cell migration (GO:0014812)2.90056894
33* positive regulation of epithelial to mesenchymal transition (GO:0010718)2.89712627
34pre-miRNA processing (GO:0031054)2.89067233
35somatic stem cell division (GO:0048103)2.88915700
36endothelial cell morphogenesis (GO:0001886)2.87036621
37coronary vasculature morphogenesis (GO:0060977)2.86593059
38regulation of apoptotic process involved in morphogenesis (GO:1902337)2.85598903
39paraxial mesoderm development (GO:0048339)2.84697659
40regulation of extracellular matrix disassembly (GO:0010715)2.83827486
41barbed-end actin filament capping (GO:0051016)2.83016303
42protein hydroxylation (GO:0018126)2.82551052
43activation of Rac GTPase activity (GO:0032863)2.81726718
44negative regulation of anoikis (GO:2000811)2.81575278
45protein retention in ER lumen (GO:0006621)2.80832664
46response to laminar fluid shear stress (GO:0034616)2.80805511
47positive regulation of histone deacetylation (GO:0031065)2.80076830
48Notch signaling involved in heart development (GO:0061314)2.79319948
49epithelial cell fate commitment (GO:0072148)2.79216976
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.78886830
51positive regulation of myotube differentiation (GO:0010831)2.78514857
52positive regulation of endothelial cell apoptotic process (GO:2000353)2.76367454
53membrane protein ectodomain proteolysis (GO:0006509)2.74430123
54myoblast fusion (GO:0007520)2.74199807
55actin filament depolymerization (GO:0030042)2.73832031
56positive regulation of osteoblast proliferation (GO:0033690)2.73181329
57regulation of glucose import in response to insulin stimulus (GO:2001273)2.67920587
58mesenchyme morphogenesis (GO:0072132)2.67910671
59embryonic process involved in female pregnancy (GO:0060136)2.66805249
60kidney mesenchyme development (GO:0072074)2.64927271
61focal adhesion assembly (GO:0048041)2.64722581
62cell-substrate adherens junction assembly (GO:0007045)2.64722581
63syncytium formation by plasma membrane fusion (GO:0000768)2.63965443
64negative regulation of fatty acid transport (GO:2000192)2.63701570
65cardiac muscle cell proliferation (GO:0060038)2.63481044
66embryonic eye morphogenesis (GO:0048048)2.63379046
67cell-substrate junction assembly (GO:0007044)2.61366858
68midgut development (GO:0007494)2.60246199
69insulin-like growth factor receptor signaling pathway (GO:0048009)2.59944187
70regulation of gamma-delta T cell differentiation (GO:0045586)2.59139503
71vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.58548889
72wound healing, spreading of cells (GO:0044319)2.58476395
73positive thymic T cell selection (GO:0045059)2.57344678
74protein heterotrimerization (GO:0070208)2.56545369
75mesodermal cell differentiation (GO:0048333)2.56541931
76regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.55226715
77lung vasculature development (GO:0060426)2.55175258
78wound healing, spreading of epidermal cells (GO:0035313)2.54343904
79branching involved in salivary gland morphogenesis (GO:0060445)2.53679512
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53234872
81endocardial cushion development (GO:0003197)2.51688081
82heart valve formation (GO:0003188)2.50357329
83embryonic camera-type eye development (GO:0031076)2.49991690
84cochlea morphogenesis (GO:0090103)2.48934088
85regulation of anoikis (GO:2000209)2.48188384
86vascular endothelial growth factor signaling pathway (GO:0038084)2.47717581
87positive regulation of Rho protein signal transduction (GO:0035025)2.47378810
88respiratory tube development (GO:0030323)2.47355260
89cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.47213846
90regulation of endothelial cell chemotaxis (GO:2001026)2.47201893
91negative regulation of cartilage development (GO:0061037)2.46682288
92endodermal cell differentiation (GO:0035987)2.46623022
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46278635
94renal system development (GO:0072001)2.46273208
95skin morphogenesis (GO:0043589)2.45699880
96type B pancreatic cell proliferation (GO:0044342)2.45343833
97* positive regulation of extracellular matrix organization (GO:1903055)2.45158100
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45134041
99regulation of heart morphogenesis (GO:2000826)2.45067604
100mammary gland epithelial cell proliferation (GO:0033598)2.45008727
101protein localization to endosome (GO:0036010)2.44920186
102negative thymic T cell selection (GO:0045060)2.44891660
103negative T cell selection (GO:0043383)2.44422137
104endothelial cell chemotaxis (GO:0035767)2.43634879
105positive regulation of receptor recycling (GO:0001921)2.43426116
106cell proliferation involved in metanephros development (GO:0072203)2.43308725
107glial cell proliferation (GO:0014009)2.42553683
108positive regulation of endothelial cell migration (GO:0010595)2.42059132
109Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.41030068
110regulation of early endosome to late endosome transport (GO:2000641)2.40762408
111peptidyl-proline hydroxylation (GO:0019511)2.40241607
112extracellular matrix assembly (GO:0085029)2.39909396
113stress fiber assembly (GO:0043149)2.39851880
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.39691594
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.39225254
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.38851778
117negative regulation of vascular permeability (GO:0043116)2.38406986
118renal filtration (GO:0097205)2.38132780
119semaphorin-plexin signaling pathway (GO:0071526)2.37982345
120regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.37345016
121vasculogenesis (GO:0001570)2.36960912
122positive regulation of epithelial cell migration (GO:0010634)2.36397393
123regulation of establishment of planar polarity (GO:0090175)2.34751567
124positive regulation of gamma-delta T cell activation (GO:0046645)2.34666485
125negative regulation of protein localization to cell surface (GO:2000009)2.34249295
126pinocytosis (GO:0006907)2.33944561
127regulation of sister chromatid cohesion (GO:0007063)2.33810979
128branching involved in mammary gland duct morphogenesis (GO:0060444)2.33480203
129retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32332020
130establishment of nucleus localization (GO:0040023)2.32219809
131germ cell migration (GO:0008354)2.31843451
132protein localization to microtubule (GO:0035372)2.31814008
133retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31609549
134apoptotic cell clearance (GO:0043277)2.31022142
135neural tube development (GO:0021915)2.30459123
136negative regulation of glial cell proliferation (GO:0060253)2.30345545
137atrioventricular valve morphogenesis (GO:0003181)2.30058776
138positive regulation of Cdc42 GTPase activity (GO:0043089)2.29992848
139regulation of gamma-delta T cell activation (GO:0046643)2.29828554
140endocytic recycling (GO:0032456)2.29337285
141positive regulation of BMP signaling pathway (GO:0030513)2.28389981
142regulation of hippo signaling (GO:0035330)2.28261479
143glomerular basement membrane development (GO:0032836)2.27431977
144metanephric mesenchyme development (GO:0072075)2.26989370
145outer ear morphogenesis (GO:0042473)2.26957635
146mitotic sister chromatid cohesion (GO:0007064)2.26880644
147notochord development (GO:0030903)2.26677218
148positive regulation of blood vessel endothelial cell migration (GO:0043536)2.26331040
149negative regulation of cardiac muscle tissue growth (GO:0055022)2.25654078
150negative regulation of heart growth (GO:0061117)2.25654078
151plasma membrane repair (GO:0001778)2.24401629
152regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.24283936
153regulation of stem cell maintenance (GO:2000036)2.23251780
154muscle cell fate commitment (GO:0042693)2.22123079
155substrate-dependent cell migration (GO:0006929)2.21666838
156striated muscle cell proliferation (GO:0014855)2.21603988
157negative regulation of cell size (GO:0045792)2.21596666
158regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.21393675
159positive regulation of mesenchymal cell proliferation (GO:0002053)2.21286564
160cartilage morphogenesis (GO:0060536)2.20618516
161lung lobe morphogenesis (GO:0060463)2.20608408
162sodium ion export (GO:0071436)2.20391221
163cell adhesion mediated by integrin (GO:0033627)2.20342623
164cardiac left ventricle morphogenesis (GO:0003214)2.19968243
165anatomical structure regression (GO:0060033)2.19952992
166apoptotic process involved in morphogenesis (GO:0060561)2.19227140
167endothelial tube morphogenesis (GO:0061154)2.18957671
168morphogenesis of an endothelium (GO:0003159)2.18957671
169negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.18110214
170negative regulation of cell killing (GO:0031342)2.18110214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.62470699
2* FOXM1_23109430_ChIP-Seq_U2OS_Human3.77014243
3* MYC_22102868_ChIP-Seq_BL_Human3.63546199
4* EGR1_19374776_ChIP-ChIP_THP-1_Human3.63484691
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.16437583
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06027639
7* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01893366
8* TCF7_22412390_ChIP-Seq_EML_Mouse2.74495610
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.60176284
10E2F7_22180533_ChIP-Seq_HELA_Human2.46895805
11KDM2B_26808549_Chip-Seq_DND41_Human2.44160836
12CLOCK_20551151_ChIP-Seq_293T_Human2.40293877
13* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.38219457
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36657876
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.35802505
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32688664
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.32383114
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.25175257
19DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.10482886
20* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.10265767
21VDR_21846776_ChIP-Seq_THP-1_Human2.05980340
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00980594
23KDM2B_26808549_Chip-Seq_JURKAT_Human2.00807166
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.93176300
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92774427
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89097490
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87631028
28* SMAD_19615063_ChIP-ChIP_OVARY_Human1.84873174
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83860276
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.81378197
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81196339
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.80443405
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78195699
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.77778530
35RUNX_20019798_ChIP-Seq_JUKART_Human1.75566248
36SCL_19346495_ChIP-Seq_HPC-7_Human1.70586082
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.70372552
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67377091
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.66723404
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66191836
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63810762
42* KDM2B_26808549_Chip-Seq_K562_Human1.62917030
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61995518
44* MAF_26560356_Chip-Seq_TH1_Human1.61400169
45ZNF263_19887448_ChIP-Seq_K562_Human1.59825877
46UTX_26944678_Chip-Seq_JUKART_Human1.56022520
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.55101282
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52518232
49* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48573678
50ATF3_27146783_Chip-Seq_COLON_Human1.47774694
51* CJUN_26792858_Chip-Seq_BT549_Human1.45853308
52RACK7_27058665_Chip-Seq_MCF-7_Human1.45444749
53AR_21909140_ChIP-Seq_LNCAP_Human1.41712828
54* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40791096
55VDR_24763502_ChIP-Seq_THP-1_Human1.38500106
56* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38269566
57LXR_22292898_ChIP-Seq_THP-1_Human1.35719673
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34465222
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32625168
60* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31187709
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31128039
62FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30926486
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30352103
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.28676734
65* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.27931533
66* BRD4_25478319_ChIP-Seq_HGPS_Human1.27568034
67NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27190518
68* TBX20_22080862_ChIP-Seq_HEART_Mouse1.26377334
69* TBX20_22328084_ChIP-Seq_HEART_Mouse1.26377334
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.26140782
71* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25225994
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24908905
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24708581
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24543038
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23451305
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23262547
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.22083241
78* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22075899
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21553204
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21247458
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20595506
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19732509
83MYB_26560356_Chip-Seq_TH2_Human1.17715089
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.17252383
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16627540
86* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16244521
87* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15565323
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.15553188
89* NCOR1_26117541_ChIP-Seq_K562_Human1.13975611
90* SPI1_23127762_ChIP-Seq_K562_Human1.11903831
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11845551
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10562997
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09761152
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09702108
95* CDX2_20551321_ChIP-Seq_CACO-2_Human1.08700456
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08693155
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.07152924
98* TP53_22127205_ChIP-Seq_IMR90_Human1.06799372
99* SOX2_20726797_ChIP-Seq_SW620_Human1.06448404
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04733572
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04369603
102TP53_16413492_ChIP-PET_HCT116_Human1.03829880
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02604659
104* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02395934
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02373365
106AHR_22903824_ChIP-Seq_MCF-7_Human1.02362198
107CREB1_26743006_Chip-Seq_LNCaP_Human1.01774324
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01463953
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.01116878
110* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00227714
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00134014
112* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99421974
113* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99072760
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98412398
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98011634
116* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97750397
117GATA6_25053715_ChIP-Seq_YYC3_Human0.97598193
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97315687
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95333909
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95300537
121MYB_26560356_Chip-Seq_TH1_Human0.95174760
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94563913
123* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94370578
124* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93333245
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.92867697
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92784943
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92426003
128* GATA1_19941826_ChIP-Seq_K562_Human0.91769320
129* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90685741
130* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90685741
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90664137
132* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89262401
133CHD1_26751641_Chip-Seq_LNCaP_Human0.89076265
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88886077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.70755953
2MP0003950_abnormal_plasma_membrane3.59697436
3MP0009780_abnormal_chondrocyte_physiolo2.89299272
4MP0003705_abnormal_hypodermis_morpholog2.81866780
5MP0000733_abnormal_muscle_development2.51848082
6MP0003300_gastrointestinal_ulcer2.50019407
7MP0008438_abnormal_cutaneous_collagen2.47115887
8MP0006054_spinal_hemorrhage2.42494417
9MP0000566_synostosis2.32140204
10MP0003279_aneurysm2.20259089
11MP0000537_abnormal_urethra_morphology2.13423125
12MP0009384_cardiac_valve_regurgitation2.11121110
13MP0002877_abnormal_melanocyte_morpholog2.09204459
14MP0004808_abnormal_hematopoietic_stem2.04729540
15MP0005623_abnormal_meninges_morphology2.03274373
16MP0002089_abnormal_postnatal_growth/wei2.02639775
17MP0010234_abnormal_vibrissa_follicle1.98629863
18MP0010352_gastrointestinal_tract_polyps1.96787454
19MP0009278_abnormal_bone_marrow1.96460865
20MP0004233_abnormal_muscle_weight1.95854882
21MP0009053_abnormal_anal_canal1.91356010
22MP0003115_abnormal_respiratory_system1.85027650
23MP0001958_emphysema1.84791637
24MP0003091_abnormal_cell_migration1.79631535
25MP0005076_abnormal_cell_differentiation1.78000569
26MP0005503_abnormal_tendon_morphology1.73131408
27MP0004084_abnormal_cardiac_muscle1.68360257
28MP0004145_abnormal_muscle_electrophysio1.68167060
29MP0010368_abnormal_lymphatic_system1.66494198
30MP0003828_pulmonary_edema1.64778766
31MP0000428_abnormal_craniofacial_morphol1.63664577
32* MP0005023_abnormal_wound_healing1.61153491
33MP0002060_abnormal_skin_morphology1.60510434
34MP0003566_abnormal_cell_adhesion1.60507403
35MP0005409_darkened_coat_color1.59260971
36MP0005508_abnormal_skeleton_morphology1.55456645
37MP0002396_abnormal_hematopoietic_system1.52879967
38MP0005451_abnormal_body_composition1.52728489
39MP0001849_ear_inflammation1.51942705
40MP0002249_abnormal_larynx_morphology1.48747496
41MP0008007_abnormal_cellular_replicative1.43909591
42MP0008961_abnormal_basal_metabolism1.42351561
43MP0003191_abnormal_cellular_cholesterol1.41535098
44MP0000762_abnormal_tongue_morphology1.41247529
45MP0001348_abnormal_lacrimal_gland1.39727534
46MP0000767_abnormal_smooth_muscle1.36161008
47MP0004185_abnormal_adipocyte_glucose1.34245777
48MP0002234_abnormal_pharynx_morphology1.33402615
49MP0000534_abnormal_ureter_morphology1.33391328
50MP0002925_abnormal_cardiovascular_devel1.32937560
51* MP0002932_abnormal_joint_morphology1.32171329
52MP0001915_intracranial_hemorrhage1.30248571
53MP0003385_abnormal_body_wall1.27559004
54MP0003045_fibrosis1.24958242
55MP0004272_abnormal_basement_membrane1.24832492
56MP0010630_abnormal_cardiac_muscle1.23448293
57MP0009250_abnormal_appendicular_skeleto1.20642174
58MP0002282_abnormal_trachea_morphology1.20582263
59MP0004858_abnormal_nervous_system1.18897357
60MP0003935_abnormal_craniofacial_develop1.18585287
61MP0005248_abnormal_Harderian_gland1.18463838
62MP0004087_abnormal_muscle_fiber1.17616420
63MP0000003_abnormal_adipose_tissue1.14904288
64MP0005275_abnormal_skin_tensile1.14711587
65* MP0003453_abnormal_keratinocyte_physiol1.11949508
66MP0003984_embryonic_growth_retardation1.11524706
67MP0002128_abnormal_blood_circulation1.11066342
68MP0002086_abnormal_extraembryonic_tissu1.10697947
69MP0002088_abnormal_embryonic_growth/wei1.10387028
70MP0000013_abnormal_adipose_tissue1.09995599
71MP0000751_myopathy1.08707733
72MP0006138_congestive_heart_failure1.08174457
73MP0002084_abnormal_developmental_patter1.06906270
74* MP0003763_abnormal_thymus_physiology1.06670592
75MP0005397_hematopoietic_system_phenotyp1.06663719
76MP0001545_abnormal_hematopoietic_system1.06663719
77MP0000467_abnormal_esophagus_morphology1.06541105
78MP0004197_abnormal_fetal_growth/weight/1.05507921
79MP0003123_paternal_imprinting1.05272726
80MP0000750_abnormal_muscle_regeneration1.04675848
81MP0003283_abnormal_digestive_organ1.04602264
82MP0002796_impaired_skin_barrier1.03368131
83MP0001542_abnormal_bone_strength1.03281481
84MP0003942_abnormal_urinary_system1.02634965
85* MP0002113_abnormal_skeleton_development1.01428278
86MP0005380_embryogenesis_phenotype0.99620994
87MP0001672_abnormal_embryogenesis/_devel0.99620994
88* MP0000350_abnormal_cell_proliferation0.98951643
89MP0000569_abnormal_digit_pigmentation0.98377408
90MP0002085_abnormal_embryonic_tissue0.98155628
91MP0003077_abnormal_cell_cycle0.97843329
92MP0001614_abnormal_blood_vessel0.97777830
93MP0001879_abnormal_lymphatic_vessel0.97012885
94MP0002269_muscular_atrophy0.95848647
95MP0005501_abnormal_skin_physiology0.94543040
96MP0001697_abnormal_embryo_size0.94303056
97MP0001243_abnormal_dermal_layer0.94006776
98MP0001299_abnormal_eye_distance/0.93882835
99MP0002998_abnormal_bone_remodeling0.92760297
100MP0005257_abnormal_intraocular_pressure0.92623154
101* MP0005164_abnormal_response_to0.92379351
102* MP0000163_abnormal_cartilage_morphology0.92157278
103MP0000266_abnormal_heart_morphology0.92102428
104* MP0002115_abnormal_skeleton_extremities0.91542479
105MP0001730_embryonic_growth_arrest0.91274307
106MP0000432_abnormal_head_morphology0.91243694
107MP0003755_abnormal_palate_morphology0.89829513
108MP0002108_abnormal_muscle_morphology0.89487827
109* MP0002109_abnormal_limb_morphology0.88229068
110* MP0000858_altered_metastatic_potential0.87709595
111MP0004134_abnormal_chest_morphology0.87176453
112MP0002166_altered_tumor_susceptibility0.87085390
113MP0002116_abnormal_craniofacial_bone0.86558896
114MP0000759_abnormal_skeletal_muscle0.86103481
115MP0005375_adipose_tissue_phenotype0.85095918
116* MP0000703_abnormal_thymus_morphology0.85062622
117MP0005621_abnormal_cell_physiology0.84871831
118MP0000462_abnormal_digestive_system0.82782442
119MP0003937_abnormal_limbs/digits/tail_de0.82062955
120MP0000049_abnormal_middle_ear0.81708270
121MP0000747_muscle_weakness0.81230474
122MP0004947_skin_inflammation0.81199533
123MP0000749_muscle_degeneration0.80634410
124MP0001784_abnormal_fluid_regulation0.80214512
125MP0004036_abnormal_muscle_relaxation0.79804023
126MP0002896_abnormal_bone_mineralization0.79441414
127MP0002106_abnormal_muscle_physiology0.79082151
128MP0002092_abnormal_eye_morphology0.78332878
129MP0005330_cardiomyopathy0.77835945
130MP0009840_abnormal_foam_cell0.77172298
131MP0005369_muscle_phenotype0.76709237
132* MP0005390_skeleton_phenotype0.75614894
133MP0005595_abnormal_vascular_smooth0.75495186
134MP0005197_abnormal_uvea_morphology0.75155495
135MP0003436_decreased_susceptibility_to0.74440984
136MP0001216_abnormal_epidermal_layer0.73826483
137MP0002295_abnormal_pulmonary_circulatio0.71811195
138MP0008260_abnormal_autophagy0.70657727
139MP0000678_abnormal_parathyroid_gland0.69219579
140MP0005666_abnormal_adipose_tissue0.68979955
141MP0005388_respiratory_system_phenotype0.68101937
142MP0002133_abnormal_respiratory_system0.68101937

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.55657262
2Shallow orbits (HP:0000586)3.51350530
3* Aortic aneurysm (HP:0004942)3.46610938
4* Protrusio acetabuli (HP:0003179)3.44896724
5Neonatal short-limb short stature (HP:0008921)3.26253068
6Spinal rigidity (HP:0003306)3.13924785
7Type 1 muscle fiber predominance (HP:0003803)2.99015489
8Fragile skin (HP:0001030)2.96408280
9Increased density of long bones (HP:0006392)2.92353910
10Wormian bones (HP:0002645)2.88797124
11* Aortic dissection (HP:0002647)2.85782344
12Distal lower limb muscle weakness (HP:0009053)2.84137809
13Short 4th metacarpal (HP:0010044)2.81812825
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.81812825
15Broad metatarsal (HP:0001783)2.78981606
16Exercise-induced myalgia (HP:0003738)2.76718797
17Vertebral compression fractures (HP:0002953)2.76316493
18Mildly elevated creatine phosphokinase (HP:0008180)2.74495123
19Short nail (HP:0001799)2.73799640
20Distal lower limb amyotrophy (HP:0008944)2.71249426
21Osteolytic defects of the hand bones (HP:0009699)2.66102974
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.66102974
23Dilatation of the ascending aorta (HP:0005111)2.60279168
24* Mitral valve prolapse (HP:0001634)2.58797163
25Ankle contracture (HP:0006466)2.56586791
26Bicuspid aortic valve (HP:0001647)2.51862109
27Abnormality of dentin (HP:0010299)2.51525369
28Hyperacusis (HP:0010780)2.50503775
29Premature rupture of membranes (HP:0001788)2.49349513
30Deviation of the hallux (HP:0010051)2.46243992
31Cervical subluxation (HP:0003308)2.41563863
32Abnormality of the 4th metacarpal (HP:0010012)2.40888685
33Hallux valgus (HP:0001822)2.39444272
34Absent frontal sinuses (HP:0002688)2.38651799
35Soft skin (HP:0000977)2.36259327
36* Aneurysm (HP:0002617)2.34902304
37Round ear (HP:0100830)2.34731321
38Blue sclerae (HP:0000592)2.33978134
39* Arterial tortuosity (HP:0005116)2.33472089
40Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.29386572
41Camptodactyly of toe (HP:0001836)2.26867594
42Asymmetric septal hypertrophy (HP:0001670)2.26349105
43* Spondylolisthesis (HP:0003302)2.24912307
44Rectal prolapse (HP:0002035)2.23686563
45Coronal craniosynostosis (HP:0004440)2.22486878
46Muscle fiber inclusion bodies (HP:0100299)2.21783788
47Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.20940053
48Abnormality of the calcaneus (HP:0008364)2.19440233
49* Joint laxity (HP:0001388)2.15968101
50Biconcave vertebral bodies (HP:0004586)2.15005043
51Renal duplication (HP:0000075)2.14343158
52Increased nuchal translucency (HP:0010880)2.12809102
53* Vascular tortuosity (HP:0004948)2.12489282
54Spinal cord lesions (HP:0100561)2.12193259
55Syringomyelia (HP:0003396)2.12193259
56Elbow flexion contracture (HP:0002987)2.10155622
57Ulnar deviation of the wrist (HP:0003049)2.09581658
58Hematochezia (HP:0002573)2.06455286
59Follicular hyperkeratosis (HP:0007502)2.06350648
60* Mitral regurgitation (HP:0001653)2.05800433
61Limited elbow extension (HP:0001377)2.03514015
62Hyporeflexia of lower limbs (HP:0002600)2.02746331
63Abnormal ossification of hand bones (HP:0005921)2.02367924
64Bladder diverticulum (HP:0000015)2.01769169
65Coxa vara (HP:0002812)2.01326682
66Overgrowth (HP:0001548)1.99861291
67Abnormality of skeletal muscle fiber size (HP:0012084)1.99484300
68Tarsal synostosis (HP:0008368)1.99219759
69Flat acetabular roof (HP:0003180)1.98185779
70Pterygium (HP:0001059)1.97819627
71Mesomelia (HP:0003027)1.97399128
72Peritonitis (HP:0002586)1.96924438
73Achilles tendon contracture (HP:0001771)1.95579850
74* Striae distensae (HP:0001065)1.95571785
75Obstructive sleep apnea (HP:0002870)1.95323163
76Atrophic scars (HP:0001075)1.95170205
77Calcaneovalgus deformity (HP:0001848)1.93947770
78Neck muscle weakness (HP:0000467)1.93361022
79Heterotopia (HP:0002282)1.93120389
80Slender build (HP:0001533)1.90791620
81Abnormality of carpal bone ossification (HP:0006257)1.90627499
82Mitral stenosis (HP:0001718)1.90562789
83Broad thumb (HP:0011304)1.89420922
84Arnold-Chiari malformation (HP:0002308)1.89397545
85Cupped ribs (HP:0000887)1.89173208
86Hyperextensible skin (HP:0000974)1.88600339
87Increased variability in muscle fiber diameter (HP:0003557)1.88549038
88Trigonocephaly (HP:0000243)1.88199831
89Deviation of the thumb (HP:0009603)1.87890723
90Subacute progressive viral hepatitis (HP:0006572)1.87550947
91Abnormality of the distal phalanx of the thumb (HP:0009617)1.85581169
92Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85559625
93Centrally nucleated skeletal muscle fibers (HP:0003687)1.85544211
94Abnormality of the fingertips (HP:0001211)1.84961479
95Narrow palate (HP:0000189)1.84437826
96Abnormality of oral frenula (HP:0000190)1.84205162
97Synostosis involving bones of the lower limbs (HP:0009138)1.84121603
98Synostosis involving bones of the feet (HP:0009140)1.84121603
99Popliteal pterygium (HP:0009756)1.83518714
100Increased connective tissue (HP:0009025)1.83428254
101Lower limb amyotrophy (HP:0007210)1.83380450
102Vertebral arch anomaly (HP:0008438)1.83361857
103Radial bowing (HP:0002986)1.83130261
104Urethral obstruction (HP:0000796)1.82221384
105Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.81982155
106Bowing of the arm (HP:0006488)1.81724128
107Bowed forearm bones (HP:0003956)1.81724128
108Broad palm (HP:0001169)1.81393567
109Genu recurvatum (HP:0002816)1.81390707
110Abnormality of the right ventricle (HP:0001707)1.81231280
111Lymphangioma (HP:0100764)1.80986945
112Deformed tarsal bones (HP:0008119)1.80753382
113Abnormality of the distal phalanges of the toes (HP:0010182)1.80615142
114Reduced subcutaneous adipose tissue (HP:0003758)1.78811459
115* Abnormality of the acetabulum (HP:0003170)1.78200275
116Nemaline bodies (HP:0003798)1.77862822
117Glucose intolerance (HP:0000833)1.77687637
118Abnormality of the epiphyses of the hand (HP:0005924)1.77608039
119Broad toe (HP:0001837)1.76704920
120Abnormality of the Achilles tendon (HP:0005109)1.76598846
121Flexion contracture of toe (HP:0005830)1.76463616
122Joint contractures involving the joints of the feet (HP:0100492)1.76463616
123Generalized amyotrophy (HP:0003700)1.76220826
124Abnormality of the left ventricular outflow tract (HP:0011103)1.76036188
125Subaortic stenosis (HP:0001682)1.76036188
126Persistence of primary teeth (HP:0006335)1.76000252
127Thin ribs (HP:0000883)1.75976090
128Broad hallux (HP:0010055)1.75396573
129Wide anterior fontanel (HP:0000260)1.75308752
130Exercise-induced muscle cramps (HP:0003710)1.74872120
131Ankyloglossia (HP:0010296)1.74686221
132Dislocated radial head (HP:0003083)1.74542380
133Difficulty running (HP:0009046)1.74483216
134Ulnar deviation of finger (HP:0009465)1.74471569
135Thin bony cortex (HP:0002753)1.74242121
136Ulnar bowing (HP:0003031)1.73128766
137Long eyelashes (HP:0000527)1.73022468
138Lumbar hyperlordosis (HP:0002938)1.72542846
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72335641
140Abnormality of the radial head (HP:0003995)1.71492216
141Spinal canal stenosis (HP:0003416)1.71029168
142Wrist flexion contracture (HP:0001239)1.70934422
143Scapular winging (HP:0003691)1.70691597
144Muscle stiffness (HP:0003552)1.69062117
145Pointed chin (HP:0000307)1.68866529
146Difficulty climbing stairs (HP:0003551)1.67837389
147Distal upper limb amyotrophy (HP:0007149)1.67787240
148Upper limb amyotrophy (HP:0009129)1.67787240
149Gastrointestinal carcinoma (HP:0002672)1.67747835
150Malignant gastrointestinal tract tumors (HP:0006749)1.67747835
151Exostoses (HP:0100777)1.67687906
152Enlarged penis (HP:0000040)1.67687744
153Annular pancreas (HP:0001734)1.67672820
154Disproportionate tall stature (HP:0001519)1.67103554
155Broad face (HP:0000283)1.66762960
156Partial duplication of the phalanx of hand (HP:0009999)1.66635819
157Selective tooth agenesis (HP:0001592)1.66346018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.19795838
2EEF2K3.95957362
3MST1R3.76984694
4PKN23.48194277
5TGFBR22.82304172
6MAP3K102.77599648
7TTN2.62269924
8MET2.44865391
9RIPK12.43765608
10STK102.31791970
11FGFR32.27268904
12SMG12.07945899
13PTK62.00255815
14LATS11.97573934
15PRPF4B1.97160344
16IRAK31.96669268
17PRKD31.86535057
18DMPK1.85070235
19PAK41.77531139
20PDGFRA1.76371792
21MOS1.75808253
22CDK121.72423665
23MYLK1.70072186
24FGFR11.69826249
25LRRK21.56581478
26NTRK11.53613770
27ERN11.49347096
28KSR11.43178489
29SIK11.32142157
30DDR21.32009540
31CDK61.24966446
32TYRO31.22404298
33MAP3K131.21181471
34MAP2K31.19802837
35MAP3K31.18849085
36CDC42BPA1.18058239
37EPHA21.16371854
38TAOK11.12360341
39RPS6KB21.11340320
40EPHB21.08928943
41MTOR1.08182079
42NEK91.07665807
43PAK21.06834189
44STK31.06743338
45KSR21.04211616
46MUSK0.99343043
47PDGFRB0.97253666
48TESK10.97009615
49MAP4K10.96952376
50FGFR40.96202379
51CAMK1D0.95290385
52ERBB40.94873635
53* MAP3K70.93598070
54TGFBR10.93163513
55RET0.90221557
56PIK3CG0.89864266
57RAF10.89017206
58BMX0.89009664
59LATS20.87359133
60TRPM70.85983249
61PTK20.84640407
62BUB10.83324769
63NEK20.82533728
64MAP3K20.82204895
65SCYL20.80320639
66MAP3K80.79595951
67LIMK10.75496527
68PRKCH0.75390692
69PRKD20.74743913
70ITK0.74496504
71ILK0.74423716
72NEK10.73888005
73CAMKK10.73571838
74OBSCN0.72871784
75JAK30.71518972
76ALK0.71058369
77AKT30.71041887
78CAMK1G0.70326148
79RPS6KA40.68889595
80EPHA30.68133223
81PRKG20.68036548
82ZAP700.67807043
83CHUK0.63701496
84STK380.62597060
85TAOK20.61879742
86EPHB10.61164575
87CSK0.59995859
88FGFR20.59354088
89PDPK10.59323840
90JAK10.58814365
91SGK30.57704447
92LMTK20.56721435
93PAK60.55191244
94FLT30.54687886
95ROCK20.53076317
96ERBB20.52368638
97MAP3K140.51699276
98HCK0.51478792
99MAPKAPK30.50963582
100GRK60.50810786
101HIPK20.50717551
102MAP2K10.49602177
103MAPK70.48505512
104MAP3K10.48135363
105MAP3K90.47534900
106MAP3K60.47493416
107TBK10.47454308
108MAP3K120.46868822
109PASK0.46587155
110MAPK110.45196038
111RPS6KA20.44869157
112TYK20.44064690
113AKT20.43775940
114* CDK40.43447075
115ARAF0.42871611
116BTK0.42544025
117CSF1R0.42526827
118WNK10.42445215
119MAPKAPK20.42137307
120MARK20.39721076
121TXK0.39447115
122PTK2B0.39360960
123SIK30.39343567
124ROCK10.37034895
125EPHA40.36443641
126CDC70.36045677
127CDK70.33591977
128* MELK0.33339315
129TTK0.32803621
130IGF1R0.31729319
131PDK10.30897645
132MAPK120.30020857
133PIK3CA0.29067882
134ICK0.29065987

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043301.85273403
2Focal adhesion_Homo sapiens_hsa045101.78345465
3* Chronic myeloid leukemia_Homo sapiens_hsa052201.77393232
4Proteoglycans in cancer_Homo sapiens_hsa052051.69491104
5Basal cell carcinoma_Homo sapiens_hsa052171.67178386
6MicroRNAs in cancer_Homo sapiens_hsa052061.64006891
7Small cell lung cancer_Homo sapiens_hsa052221.62492954
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61360578
9ECM-receptor interaction_Homo sapiens_hsa045121.60630639
10* Adherens junction_Homo sapiens_hsa045201.51618907
11Dilated cardiomyopathy_Homo sapiens_hsa054141.47955562
12* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45381033
13* Pancreatic cancer_Homo sapiens_hsa052121.45050520
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43935152
15* Colorectal cancer_Homo sapiens_hsa052101.43725437
16Bladder cancer_Homo sapiens_hsa052191.42950694
17* Hippo signaling pathway_Homo sapiens_hsa043901.42917221
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.39639011
19Platelet activation_Homo sapiens_hsa046111.35190805
20Non-small cell lung cancer_Homo sapiens_hsa052231.34824340
21mTOR signaling pathway_Homo sapiens_hsa041501.34801822
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32491094
23Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27434292
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.25610662
25* HTLV-I infection_Homo sapiens_hsa051661.25451159
26Dorso-ventral axis formation_Homo sapiens_hsa043201.23516228
27Endometrial cancer_Homo sapiens_hsa052131.20209918
28Viral myocarditis_Homo sapiens_hsa054161.17493228
29Glioma_Homo sapiens_hsa052141.15704464
30B cell receptor signaling pathway_Homo sapiens_hsa046621.15620545
31T cell receptor signaling pathway_Homo sapiens_hsa046601.14687868
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14039642
33Hedgehog signaling pathway_Homo sapiens_hsa043401.13123829
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12696435
35VEGF signaling pathway_Homo sapiens_hsa043701.12583402
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.08518096
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07953025
38Rap1 signaling pathway_Homo sapiens_hsa040151.05593358
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04585257
40Acute myeloid leukemia_Homo sapiens_hsa052211.04266072
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03447314
42Pentose phosphate pathway_Homo sapiens_hsa000301.02719635
43* TGF-beta signaling pathway_Homo sapiens_hsa043501.02656618
44* Pathways in cancer_Homo sapiens_hsa052001.00476122
45Osteoclast differentiation_Homo sapiens_hsa043800.99613235
46Toxoplasmosis_Homo sapiens_hsa051450.99128895
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98983674
48Hepatitis C_Homo sapiens_hsa051600.96463590
49* Hepatitis B_Homo sapiens_hsa051610.95918396
50* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95661997
51GnRH signaling pathway_Homo sapiens_hsa049120.95262274
52Other glycan degradation_Homo sapiens_hsa005110.95058391
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94196609
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93509129
55* Wnt signaling pathway_Homo sapiens_hsa043100.93198237
56Oxytocin signaling pathway_Homo sapiens_hsa049210.92858673
57* Cell cycle_Homo sapiens_hsa041100.92783312
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.92588211
59HIF-1 signaling pathway_Homo sapiens_hsa040660.91897386
60Melanoma_Homo sapiens_hsa052180.91662305
61Amoebiasis_Homo sapiens_hsa051460.89476871
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88982646
63Shigellosis_Homo sapiens_hsa051310.88210535
64Leishmaniasis_Homo sapiens_hsa051400.87177793
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86859004
66* Endocytosis_Homo sapiens_hsa041440.85938335
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85893706
68* FoxO signaling pathway_Homo sapiens_hsa040680.85889304
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85232922
70Renal cell carcinoma_Homo sapiens_hsa052110.85023122
71MAPK signaling pathway_Homo sapiens_hsa040100.84941548
72Melanogenesis_Homo sapiens_hsa049160.84852208
73Prion diseases_Homo sapiens_hsa050200.84366686
74Thyroid cancer_Homo sapiens_hsa052160.84236480
75TNF signaling pathway_Homo sapiens_hsa046680.84010680
76Prolactin signaling pathway_Homo sapiens_hsa049170.83829757
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82990782
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81949468
79Lysine degradation_Homo sapiens_hsa003100.81560504
80Insulin resistance_Homo sapiens_hsa049310.81119175
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80972461
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79656610
83Fructose and mannose metabolism_Homo sapiens_hsa000510.79221347
84Galactose metabolism_Homo sapiens_hsa000520.79208402
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78345156
86Tight junction_Homo sapiens_hsa045300.78177336
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77644689
88Inositol phosphate metabolism_Homo sapiens_hsa005620.75954358
89Estrogen signaling pathway_Homo sapiens_hsa049150.75295028
90Axon guidance_Homo sapiens_hsa043600.73875387
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73292002
92Choline metabolism in cancer_Homo sapiens_hsa052310.73161431
93ErbB signaling pathway_Homo sapiens_hsa040120.72106755
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71806823
95Viral carcinogenesis_Homo sapiens_hsa052030.71381918
96Circadian rhythm_Homo sapiens_hsa047100.70442703
97Prostate cancer_Homo sapiens_hsa052150.70109260
98* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69772905
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69681752
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69603050
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69369525
102Gap junction_Homo sapiens_hsa045400.69351463
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.68289748
104Insulin signaling pathway_Homo sapiens_hsa049100.67823881
105p53 signaling pathway_Homo sapiens_hsa041150.66019104
106* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65374300
107AMPK signaling pathway_Homo sapiens_hsa041520.63839356
108Protein digestion and absorption_Homo sapiens_hsa049740.63691213
109Glucagon signaling pathway_Homo sapiens_hsa049220.63641783
110Apoptosis_Homo sapiens_hsa042100.61063096
111Oocyte meiosis_Homo sapiens_hsa041140.60466670
112Influenza A_Homo sapiens_hsa051640.59375850
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.59226426
114Malaria_Homo sapiens_hsa051440.58315891
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.57608609
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56645781
117cAMP signaling pathway_Homo sapiens_hsa040240.56334597
118Nitrogen metabolism_Homo sapiens_hsa009100.56286969
119Chemokine signaling pathway_Homo sapiens_hsa040620.55797337
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.55666234
121Measles_Homo sapiens_hsa051620.54700801
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54475893

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