SMAD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)4.40931540
2interkinetic nuclear migration (GO:0022027)4.19726332
3nucleus localization (GO:0051647)3.85858882
4regulation of pigment cell differentiation (GO:0050932)3.81038366
5cytoplasmic mRNA processing body assembly (GO:0033962)3.78873916
6establishment of nucleus localization (GO:0040023)3.71162090
7histone H3-K9 demethylation (GO:0033169)3.62972618
8hippo signaling (GO:0035329)3.48805304
9genitalia morphogenesis (GO:0035112)3.34578339
10regulation of NFAT protein import into nucleus (GO:0051532)3.32153765
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.30303209
12positive regulation of developmental pigmentation (GO:0048087)3.28980977
13histone lysine demethylation (GO:0070076)3.27644811
14phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.19008257
15nuclear pore complex assembly (GO:0051292)3.12120041
16nuclear pore organization (GO:0006999)3.07570098
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.05935288
18negative regulation of translation, ncRNA-mediated (GO:0040033)3.05935288
19regulation of translation, ncRNA-mediated (GO:0045974)3.05935288
20regulation of hippo signaling (GO:0035330)3.03412070
21* positive regulation of SMAD protein import into nucleus (GO:0060391)3.03210117
22regulation of histone H3-K9 methylation (GO:0051570)3.01846751
23histone demethylation (GO:0016577)2.97725558
24endocardial cushion development (GO:0003197)2.95122720
25morphogenesis of an endothelium (GO:0003159)2.94714975
26endothelial tube morphogenesis (GO:0061154)2.94714975
27polarized epithelial cell differentiation (GO:0030859)2.94524485
28pre-miRNA processing (GO:0031054)2.93881250
29embryonic process involved in female pregnancy (GO:0060136)2.91960296
30* regulation of SMAD protein import into nucleus (GO:0060390)2.89431614
31paraxial mesoderm development (GO:0048339)2.86224663
32regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.85132096
33monoubiquitinated protein deubiquitination (GO:0035520)2.84093018
34positive regulation of histone deacetylation (GO:0031065)2.82422352
35germ cell migration (GO:0008354)2.82212135
36embryonic retina morphogenesis in camera-type eye (GO:0060059)2.81256082
37cardiac myofibril assembly (GO:0055003)2.80999743
38myofibril assembly (GO:0030239)2.78922882
39* regulation of transforming growth factor beta2 production (GO:0032909)2.74028093
40negative regulation of fatty acid transport (GO:2000192)2.71749093
41hemidesmosome assembly (GO:0031581)2.70752572
42V(D)J recombination (GO:0033151)2.70174100
43trophectodermal cell differentiation (GO:0001829)2.69996563
44positive regulation of catenin import into nucleus (GO:0035413)2.69297931
45heterochromatin organization (GO:0070828)2.68371498
46cell migration involved in sprouting angiogenesis (GO:0002042)2.67377265
47negative regulation of cell fate specification (GO:0009996)2.66436497
48regulation of RNA export from nucleus (GO:0046831)2.63796821
49NLS-bearing protein import into nucleus (GO:0006607)2.62292076
50endodermal cell differentiation (GO:0035987)2.62148416
51heart morphogenesis (GO:0003007)2.62148183
52epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61288194
53regulation of gene silencing by RNA (GO:0060966)2.61166736
54regulation of posttranscriptional gene silencing (GO:0060147)2.61166736
55regulation of gene silencing by miRNA (GO:0060964)2.61166736
56cell adhesion mediated by integrin (GO:0033627)2.60677100
57mRNA stabilization (GO:0048255)2.59182454
58RNA stabilization (GO:0043489)2.59182454
59adherens junction assembly (GO:0034333)2.58595728
60embryonic foregut morphogenesis (GO:0048617)2.58196004
61peptidyl-threonine phosphorylation (GO:0018107)2.57213836
62regulation of cardioblast differentiation (GO:0051890)2.56942497
63positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.56315268
64cellular response to ethanol (GO:0071361)2.55200395
65regulation of gene silencing (GO:0060968)2.54891069
66neuronal stem cell maintenance (GO:0097150)2.54676625
67mitotic sister chromatid cohesion (GO:0007064)2.54128914
68negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.53157533
69epithelial cell-cell adhesion (GO:0090136)2.52950984
70regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.51636205
71* positive regulation of epithelial to mesenchymal transition (GO:0010718)2.50807661
72peptidyl-lysine dimethylation (GO:0018027)2.50257730
73vascular endothelial growth factor signaling pathway (GO:0038084)2.49782733
74dorsal/ventral axis specification (GO:0009950)2.48147475
75protein localization to endosome (GO:0036010)2.47848447
76DNA damage induced protein phosphorylation (GO:0006975)2.47046057
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.46327626
78positive regulation of glycogen biosynthetic process (GO:0045725)2.45846107
79peptidyl-threonine modification (GO:0018210)2.45771249
80cell-substrate junction assembly (GO:0007044)2.45457549
81regulation of sister chromatid cohesion (GO:0007063)2.44827651
82* regulation of heart morphogenesis (GO:2000826)2.44483964
83protein heterotrimerization (GO:0070208)2.44263216
84growth hormone receptor signaling pathway (GO:0060396)2.43929928
85negative regulation of histone methylation (GO:0031061)2.41541097
86protein demethylation (GO:0006482)2.41210206
87protein dealkylation (GO:0008214)2.41210206
88regulation of nucleobase-containing compound transport (GO:0032239)2.40882227
89regulation of integrin activation (GO:0033623)2.40734747
90protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.39983684
91nodal signaling pathway (GO:0038092)2.39935018
92convergent extension (GO:0060026)2.38213871
93fibroblast migration (GO:0010761)2.38042007
94* gastrulation with mouth forming second (GO:0001702)2.35477109
95embryonic camera-type eye morphogenesis (GO:0048596)2.35223971
96regulation of chromatin silencing (GO:0031935)2.34702453
97neural tube development (GO:0021915)2.34461174
98phospholipid translocation (GO:0045332)2.34347798
99lipid translocation (GO:0034204)2.34347798
100positive regulation of blood vessel endothelial cell migration (GO:0043536)2.32641356
101negative regulation of DNA repair (GO:0045738)2.32032275
102branching involved in prostate gland morphogenesis (GO:0060442)2.31656013
103glucocorticoid receptor signaling pathway (GO:0042921)2.30401979
104collagen fibril organization (GO:0030199)2.30353715
105negative regulation of cell cycle G2/M phase transition (GO:1902750)2.29450662
106positive regulation of p38MAPK cascade (GO:1900745)2.28798273
107embryonic heart tube development (GO:0035050)2.27226767
108morphogenesis of an epithelial sheet (GO:0002011)2.27142658
109regulation of protein polyubiquitination (GO:1902914)2.26449983
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.26289792
111mesodermal cell differentiation (GO:0048333)2.25579815
112pore complex assembly (GO:0046931)2.24515939
113face morphogenesis (GO:0060325)2.23478461
114positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.22800029
115regulation of growth hormone secretion (GO:0060123)2.21988186
116radial glial cell differentiation (GO:0060019)2.21967543
117basement membrane organization (GO:0071711)2.21945606
118chromatin assembly (GO:0031497)2.21767528
119establishment of epithelial cell polarity (GO:0090162)2.21620063
120glomerulus development (GO:0032835)2.21564818
121adult heart development (GO:0007512)2.21460396
122regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.21298016
123cardiac muscle hypertrophy (GO:0003300)2.21279600
124regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.20770260
125regulation of interleukin-12 biosynthetic process (GO:0045075)2.19822572
126ectodermal placode formation (GO:0060788)2.19646260
127notochord development (GO:0030903)2.18556036
128retina vasculature morphogenesis in camera-type eye (GO:0061299)2.17822763
129sister chromatid cohesion (GO:0007062)2.17410246
130anterior/posterior axis specification, embryo (GO:0008595)2.17248477
131generation of neurons (GO:0048699)2.16947080
132positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.16648346
133centrosome localization (GO:0051642)2.16549584
134anatomical structure regression (GO:0060033)2.15906293
135response to laminar fluid shear stress (GO:0034616)2.15535215
136positive regulation of hormone biosynthetic process (GO:0046886)2.14231607
137cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.14132735
138DNA unwinding involved in DNA replication (GO:0006268)2.14123979
139definitive hemopoiesis (GO:0060216)2.13828740
140dosage compensation (GO:0007549)2.13579342
141corticosteroid receptor signaling pathway (GO:0031958)2.13297742
142regulation of cell fate specification (GO:0042659)2.13115406
143pericardium development (GO:0060039)2.13064326
144coronary vasculature morphogenesis (GO:0060977)2.12537427
145patterning of blood vessels (GO:0001569)2.11980342
146NIK/NF-kappaB signaling (GO:0038061)2.11378352
147mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.11201155
148focal adhesion assembly (GO:0048041)2.10928621
149cell-substrate adherens junction assembly (GO:0007045)2.10928621
150histone-serine phosphorylation (GO:0035404)2.10905561
151stress fiber assembly (GO:0043149)2.10869399
152regulation of non-canonical Wnt signaling pathway (GO:2000050)2.10844509
153positive regulation of mesenchymal cell proliferation (GO:0002053)2.10593378
154positive regulation of glycoprotein biosynthetic process (GO:0010560)2.10330173
155blood vessel endothelial cell migration (GO:0043534)2.10277648
156embryonic eye morphogenesis (GO:0048048)2.09855592
157striated muscle hypertrophy (GO:0014897)2.08386953
158negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.08298609
159cellular response to sterol (GO:0036315)2.08155202
160somitogenesis (GO:0001756)2.08110207
161snRNA transcription (GO:0009301)2.07164462
162regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.06707554
163chondrocyte development (GO:0002063)2.04613859
164negative regulation of fibroblast apoptotic process (GO:2000270)2.04018538
165mitotic chromosome condensation (GO:0007076)2.03413129
166cardiac muscle adaptation (GO:0014887)2.03380126
167muscle hypertrophy in response to stress (GO:0003299)2.03380126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.63799250
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.42438793
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.16717083
4E2F7_22180533_ChIP-Seq_HELA_Human3.21960733
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.04300641
6CLOCK_20551151_ChIP-Seq_293T_Human2.85505998
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.81092945
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.78978762
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.71896849
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.63375639
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41398408
12MYC_22102868_ChIP-Seq_BL_Human2.36903176
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27776010
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22308201
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19767592
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.16231206
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.14871120
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09030400
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00207710
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.98195275
21TCF7_22412390_ChIP-Seq_EML_Mouse1.94549781
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.94517825
23* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91380526
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89901844
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.88995984
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.88800759
27AR_21572438_ChIP-Seq_LNCaP_Human1.88638884
28* FOXO3_23340844_ChIP-Seq_DLD1_Human1.84424404
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82207892
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81737821
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76946758
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76115183
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75896051
34KDM2B_26808549_Chip-Seq_DND41_Human1.75134385
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72687523
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.71995747
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69518336
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69518336
39GBX2_23144817_ChIP-Seq_PC3_Human1.69035565
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.68061195
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67861042
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66626512
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65231484
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.63842412
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.62664783
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61085039
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.60837007
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60401900
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59151507
50AR_21909140_ChIP-Seq_LNCAP_Human1.58305765
51FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.56693146
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.56589817
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55406704
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55349892
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.54336688
56* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53848790
57* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53259227
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52939097
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52687492
60TAF15_26573619_Chip-Seq_HEK293_Human1.51648606
61FUS_26573619_Chip-Seq_HEK293_Human1.50165475
62TP53_16413492_ChIP-PET_HCT116_Human1.50144823
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.49917848
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49824807
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49377872
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.49337726
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48892764
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48771539
69BRD4_25478319_ChIP-Seq_HGPS_Human1.48609795
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48583145
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48443490
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48441911
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48441911
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45429206
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.44590911
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.44469218
77ATF3_27146783_Chip-Seq_COLON_Human1.43818298
78GATA6_25053715_ChIP-Seq_YYC3_Human1.43572830
79SMAD4_21799915_ChIP-Seq_A2780_Human1.43493407
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43409740
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.42638371
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39382251
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.39092952
84P300_19829295_ChIP-Seq_ESCs_Human1.38560672
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.38260584
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38009334
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37787804
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37528923
89ZNF263_19887448_ChIP-Seq_K562_Human1.36895064
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36614346
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35439623
92IGF1R_20145208_ChIP-Seq_DFB_Human1.34573663
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34260676
94STAT3_23295773_ChIP-Seq_U87_Human1.33926307
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33021251
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32652402
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.32621512
98MAF_26560356_Chip-Seq_TH1_Human1.32211352
99* CHD1_26751641_Chip-Seq_LNCaP_Human1.32144452
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.31744569
101NCOR1_26117541_ChIP-Seq_K562_Human1.30393891
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30349027
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30311669
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30264138
105RACK7_27058665_Chip-Seq_MCF-7_Human1.30039556
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29728887
107ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28108017
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25596309
109VDR_21846776_ChIP-Seq_THP-1_Human1.25156055
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24932132
111UTX_26944678_Chip-Seq_JUKART_Human1.22362146
112* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22191670
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.22095633
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21952140
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21331642
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20636952
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19689982
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19689982
119* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19306920
120TCF4_23295773_ChIP-Seq_U87_Human1.19085670
121ISL1_27105846_Chip-Seq_CPCs_Mouse1.18561137
122TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18538006
123BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18510954
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18440504
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18424967
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.18063726
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17622869
128TCF4_18268006_ChIP-ChIP_LS174T_Human1.17574756
129* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17104364
130* TBX20_22328084_ChIP-Seq_HEART_Mouse1.16952451
131* TBX20_22080862_ChIP-Seq_HEART_Mouse1.16952451
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15787019
133FLI1_27457419_Chip-Seq_LIVER_Mouse1.15506073
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14601415
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14593986
136SMAD3_21741376_ChIP-Seq_HESCs_Human1.13689864
137EWS_26573619_Chip-Seq_HEK293_Human1.13250979
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12744729
139SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12389950
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12274171
141CJUN_26792858_Chip-Seq_BT549_Human1.11246871
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10863981
143EZH2_22144423_ChIP-Seq_EOC_Human1.10828403
144EZH2_27294783_Chip-Seq_NPCs_Mouse1.10407651
145ARNT_22903824_ChIP-Seq_MCF-7_Human1.10358474
146MYB_26560356_Chip-Seq_TH2_Human1.09707100
147LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09372013
148SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09321689
149* SOX9_26525672_Chip-Seq_HEART_Mouse1.09167691
150CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08765755
151* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07770986
152NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07188742
153GATA1_22025678_ChIP-Seq_K562_Human1.07026524
154* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05525339
155E2F1_18555785_Chip-Seq_ESCs_Mouse1.05181172
156* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05146465
157PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04946969
158KDM2B_26808549_Chip-Seq_K562_Human1.04566789
159GF1B_26923725_Chip-Seq_HPCs_Mouse1.03996790
160SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03774726
161RXR_22108803_ChIP-Seq_LS180_Human1.02688769
162CDX2_20551321_ChIP-Seq_CACO-2_Human1.02151691
163HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01787979
164EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01495435
165NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01449258
166PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01279972
167MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00872100
168TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00700484
169SOX2_21211035_ChIP-Seq_LN229_Gbm1.00181131
170RUNX_20019798_ChIP-Seq_JUKART_Human0.99072699
171JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97673315
172MYB_26560356_Chip-Seq_TH1_Human0.97633751
173KLF5_25053715_ChIP-Seq_YYC3_Human0.97604152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.52990559
2MP0010234_abnormal_vibrissa_follicle3.54536004
3* MP0003890_abnormal_embryonic-extraembry3.22148119
4MP0000569_abnormal_digit_pigmentation3.03593009
5* MP0003705_abnormal_hypodermis_morpholog3.02584048
6MP0003136_yellow_coat_color2.62493355
7MP0005076_abnormal_cell_differentiation2.60734377
8MP0008438_abnormal_cutaneous_collagen2.59985459
9MP0000537_abnormal_urethra_morphology2.48638504
10* MP0010352_gastrointestinal_tract_polyps2.40520609
11MP0003941_abnormal_skin_development2.39593274
12MP0003300_gastrointestinal_ulcer2.25205561
13MP0002254_reproductive_system_inflammat2.24694154
14MP0003646_muscle_fatigue2.10360194
15MP0010030_abnormal_orbit_morphology2.06431760
16MP0003045_fibrosis1.97907306
17MP0004272_abnormal_basement_membrane1.93746440
18MP0009053_abnormal_anal_canal1.93568948
19MP0006054_spinal_hemorrhage1.92426722
20MP0005275_abnormal_skin_tensile1.85221589
21MP0005623_abnormal_meninges_morphology1.82607909
22MP0009278_abnormal_bone_marrow1.82506773
23MP0000733_abnormal_muscle_development1.78537420
24MP0009384_cardiac_valve_regurgitation1.75880146
25MP0003566_abnormal_cell_adhesion1.74182733
26MP0002877_abnormal_melanocyte_morpholog1.70190789
27MP0004130_abnormal_muscle_cell1.60475461
28MP0003567_abnormal_fetal_cardiomyocyte1.57845146
29MP0003091_abnormal_cell_migration1.55313794
30MP0003279_aneurysm1.51146721
31MP0005409_darkened_coat_color1.49307697
32MP0001849_ear_inflammation1.45165988
33MP0003385_abnormal_body_wall1.44578312
34MP0003123_paternal_imprinting1.43615895
35MP0002108_abnormal_muscle_morphology1.43147935
36MP0000516_abnormal_urinary_system1.42709297
37MP0005367_renal/urinary_system_phenotyp1.42709297
38MP0009672_abnormal_birth_weight1.41592929
39MP0002233_abnormal_nose_morphology1.39341860
40MP0004145_abnormal_muscle_electrophysio1.38995896
41MP0001915_intracranial_hemorrhage1.38747197
42MP0002166_altered_tumor_susceptibility1.37119340
43MP0005503_abnormal_tendon_morphology1.35943760
44MP0005171_absent_coat_pigmentation1.35833776
45MP0005023_abnormal_wound_healing1.35692643
46MP0004197_abnormal_fetal_growth/weight/1.34764187
47MP0010678_abnormal_skin_adnexa1.33092931
48MP0000767_abnormal_smooth_muscle1.31864747
49MP0003828_pulmonary_edema1.30561785
50MP0002168_other_aberrant_phenotype1.25921408
51MP0005248_abnormal_Harderian_gland1.24148964
52MP0000428_abnormal_craniofacial_morphol1.24025582
53MP0002837_dystrophic_cardiac_calcinosis1.23119228
54MP0004087_abnormal_muscle_fiber1.19447734
55MP0002925_abnormal_cardiovascular_devel1.19022854
56MP0000778_abnormal_nervous_system1.18844599
57MP0006138_congestive_heart_failure1.17491935
58* MP0002086_abnormal_extraembryonic_tissu1.17071688
59MP0000749_muscle_degeneration1.16253887
60MP0004185_abnormal_adipocyte_glucose1.16048974
61MP0002396_abnormal_hematopoietic_system1.15828506
62MP0002009_preneoplasia1.15779507
63MP0001879_abnormal_lymphatic_vessel1.15050131
64MP0005187_abnormal_penis_morphology1.14414395
65MP0004036_abnormal_muscle_relaxation1.13974834
66MP0003935_abnormal_craniofacial_develop1.12576629
67MP0001958_emphysema1.11951785
68MP0003221_abnormal_cardiomyocyte_apopto1.10819389
69MP0001873_stomach_inflammation1.10580677
70MP0002006_tumorigenesis1.10322148
71* MP0002084_abnormal_developmental_patter1.09821242
72MP0000432_abnormal_head_morphology1.09340379
73MP0002282_abnormal_trachea_morphology1.08595555
74MP0004264_abnormal_extraembryonic_tissu1.08289207
75* MP0002088_abnormal_embryonic_growth/wei1.07547002
76MP0002106_abnormal_muscle_physiology1.07204240
77MP0003115_abnormal_respiratory_system1.06829343
78MP0002092_abnormal_eye_morphology1.06451706
79* MP0003984_embryonic_growth_retardation1.05737045
80MP0003937_abnormal_limbs/digits/tail_de1.05179308
81MP0010368_abnormal_lymphatic_system1.05073973
82MP0005508_abnormal_skeleton_morphology1.02970166
83MP0001661_extended_life_span1.02690842
84MP0000462_abnormal_digestive_system1.02456922
85MP0010630_abnormal_cardiac_muscle1.02156237
86MP0002896_abnormal_bone_mineralization1.01223620
87MP0001293_anophthalmia1.01073097
88* MP0005380_embryogenesis_phenotype1.00342725
89* MP0001672_abnormal_embryogenesis/_devel1.00342725
90MP0005369_muscle_phenotype0.99780193
91* MP0002060_abnormal_skin_morphology0.99628781
92* MP0002085_abnormal_embryonic_tissue0.96956822
93MP0005620_abnormal_muscle_contractility0.96551438
94MP0003942_abnormal_urinary_system0.96242554
95MP0000685_abnormal_immune_system0.95929222
96MP0000534_abnormal_ureter_morphology0.95382519
97MP0002932_abnormal_joint_morphology0.95096055
98MP0003755_abnormal_palate_morphology0.94527442
99MP0003868_abnormal_feces_composition0.94375539
100* MP0001730_embryonic_growth_arrest0.94300829
101MP0002269_muscular_atrophy0.94213102
102* MP0000350_abnormal_cell_proliferation0.93681811
103* MP0003861_abnormal_nervous_system0.93652002
104MP0002697_abnormal_eye_size0.93454853
105* MP0003453_abnormal_keratinocyte_physiol0.93397436
106MP0010307_abnormal_tumor_latency0.92364024
107MP0003119_abnormal_digestive_system0.92332725
108* MP0001697_abnormal_embryo_size0.91749487
109MP0002111_abnormal_tail_morphology0.91257648
110MP0002098_abnormal_vibrissa_morphology0.89089813
111MP0000383_abnormal_hair_follicle0.88323957
112MP0004084_abnormal_cardiac_muscle0.87742114
113MP0002138_abnormal_hepatobiliary_system0.87630306
114MP0002128_abnormal_blood_circulation0.87554763
115MP0001614_abnormal_blood_vessel0.87507742
116MP0000759_abnormal_skeletal_muscle0.85319631
117MP0004808_abnormal_hematopoietic_stem0.85133562
118MP0010155_abnormal_intestine_physiology0.84424381
119MP0001784_abnormal_fluid_regulation0.83831425
120MP0001346_abnormal_lacrimal_gland0.83702152
121MP0001188_hyperpigmentation0.83016888
122MP0002081_perinatal_lethality0.82135037
123MP0000266_abnormal_heart_morphology0.81702453
124MP0002114_abnormal_axial_skeleton0.81420191
125MP0009703_decreased_birth_body0.80289476
126MP0009250_abnormal_appendicular_skeleto0.79991502
127MP0002653_abnormal_ependyma_morphology0.79766836
128MP0003283_abnormal_digestive_organ0.79709409
129MP0002115_abnormal_skeleton_extremities0.79646086
130MP0001177_atelectasis0.79135289
131MP0005085_abnormal_gallbladder_physiolo0.79102977
132MP0000003_abnormal_adipose_tissue0.78812512
133MP0002249_abnormal_larynx_morphology0.78701847
134MP0005375_adipose_tissue_phenotype0.78072249
135MP0002113_abnormal_skeleton_development0.77256200
136MP0002109_abnormal_limb_morphology0.77185155
137MP0002116_abnormal_craniofacial_bone0.76764695
138* MP0004957_abnormal_blastocyst_morpholog0.76403951
139MP0005666_abnormal_adipose_tissue0.75854918
140MP0005257_abnormal_intraocular_pressure0.74945937
141MP0001299_abnormal_eye_distance/0.74845841
142MP0001286_abnormal_eye_development0.74673953

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.62627330
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.62627330
3Protrusio acetabuli (HP:0003179)3.45650634
4Shallow orbits (HP:0000586)3.44525100
5Cerebral aneurysm (HP:0004944)3.22817452
6Subacute progressive viral hepatitis (HP:0006572)3.13434374
7Papillary thyroid carcinoma (HP:0002895)3.11260386
8Aortic aneurysm (HP:0004942)3.04563777
9Abnormality of the 4th metacarpal (HP:0010012)3.02871695
10Aortic dissection (HP:0002647)3.00580067
11Hepatoblastoma (HP:0002884)2.99698512
12Increased density of long bones (HP:0006392)2.85899840
13Arterial tortuosity (HP:0005116)2.79034554
14Premature rupture of membranes (HP:0001788)2.77818001
15Ankle contracture (HP:0006466)2.70847075
16Vascular tortuosity (HP:0004948)2.67556424
17* Mitral valve prolapse (HP:0001634)2.61278347
18Narrow palate (HP:0000189)2.57576190
19Atrophic scars (HP:0001075)2.47801381
20Right ventricular cardiomyopathy (HP:0011663)2.46685623
21Neonatal hypoglycemia (HP:0001998)2.40496964
22Wrist flexion contracture (HP:0001239)2.39543997
23Dilatation of the ascending aorta (HP:0005111)2.38544553
24Deviation of the thumb (HP:0009603)2.28098122
25Abnormality of the left ventricular outflow tract (HP:0011103)2.27102588
26Subaortic stenosis (HP:0001682)2.27102588
27Persistence of primary teeth (HP:0006335)2.26681885
28Increased connective tissue (HP:0009025)2.26083979
29* Hematochezia (HP:0002573)2.24861520
30Aneurysm (HP:0002617)2.24449009
31Truncal obesity (HP:0001956)2.23068824
32Cutaneous finger syndactyly (HP:0010554)2.22372684
33Cutaneous syndactyly (HP:0012725)2.19090497
34Asymmetry of the thorax (HP:0001555)2.16732438
35Hypoplastic ischia (HP:0003175)2.16421428
36Hypoplastic labia majora (HP:0000059)2.16241184
37Milia (HP:0001056)2.15528876
38Abnormality of incisor morphology (HP:0011063)2.15367860
39Hyperkalemia (HP:0002153)2.14641645
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.13155751
41Volvulus (HP:0002580)2.10935236
42Dysmetric saccades (HP:0000641)2.09325671
43Camptodactyly of toe (HP:0001836)2.06811340
44Nephroblastoma (Wilms tumor) (HP:0002667)2.06722928
45Osteolytic defects of the hand bones (HP:0009699)2.06132135
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.06132135
47Proximal placement of thumb (HP:0009623)2.05593589
48Heterotopia (HP:0002282)2.05426330
49Bicuspid aortic valve (HP:0001647)2.03644819
50Acanthocytosis (HP:0001927)2.01438732
51Embryonal renal neoplasm (HP:0011794)2.00984447
52Ulnar bowing (HP:0003031)2.00634890
53* Gastrointestinal carcinoma (HP:0002672)2.00082870
54* Malignant gastrointestinal tract tumors (HP:0006749)2.00082870
55Cervical subluxation (HP:0003308)1.99681642
56Abnormality of the fingertips (HP:0001211)1.99211816
57Biliary tract neoplasm (HP:0100574)1.97642733
58* Rectal prolapse (HP:0002035)1.97468237
59Broad thumb (HP:0011304)1.96534840
60Broad metatarsal (HP:0001783)1.95995351
61Viral hepatitis (HP:0006562)1.94106218
62Abnormality of the labia majora (HP:0012881)1.93242296
63Neoplasm of the heart (HP:0100544)1.92305148
64Coronal craniosynostosis (HP:0004440)1.92302475
65Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90955713
66Bladder diverticulum (HP:0000015)1.90525438
67Difficulty running (HP:0009046)1.89371038
68Abnormal pancreas size (HP:0012094)1.89263934
69Abnormality of the gastric mucosa (HP:0004295)1.88758707
70Micronodular cirrhosis (HP:0001413)1.88166788
71Renal duplication (HP:0000075)1.88129242
72Broad palm (HP:0001169)1.87528284
73Thyroid carcinoma (HP:0002890)1.86850530
74Sandal gap (HP:0001852)1.84211859
75Germ cell neoplasia (HP:0100728)1.83157943
76Genu recurvatum (HP:0002816)1.82951474
77Wormian bones (HP:0002645)1.82288427
78Wide anterior fontanel (HP:0000260)1.81054433
79Preaxial foot polydactyly (HP:0001841)1.80122674
80Macroorchidism (HP:0000053)1.79616045
81Fragile skin (HP:0001030)1.78147852
82Deviation of the hallux (HP:0010051)1.77845529
83Syringomyelia (HP:0003396)1.77755243
84Tracheomalacia (HP:0002779)1.76868748
85Proximal amyotrophy (HP:0007126)1.76531625
86Abnormality of the ischium (HP:0003174)1.76317206
87Mildly elevated creatine phosphokinase (HP:0008180)1.75191976
88Trigonocephaly (HP:0000243)1.75137766
89High anterior hairline (HP:0009890)1.74687312
90Enlarged penis (HP:0000040)1.74203589
91Abnormality of chromosome segregation (HP:0002916)1.73640847
92Soft skin (HP:0000977)1.72496606
93Cystic hygroma (HP:0000476)1.71748625
94Spinal rigidity (HP:0003306)1.71728108
95Disproportionate tall stature (HP:0001519)1.71371441
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71369582
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70639292
98Acute myeloid leukemia (HP:0004808)1.70371405
99Thin bony cortex (HP:0002753)1.70188624
100Peritonitis (HP:0002586)1.69588335
101Deep philtrum (HP:0002002)1.69415820
102Omphalocele (HP:0001539)1.69342728
103Long eyelashes (HP:0000527)1.68610739
104Anal stenosis (HP:0002025)1.68505705
105Uterine leiomyosarcoma (HP:0002891)1.68215324
106Leiomyosarcoma (HP:0100243)1.68215324
107Cubitus valgus (HP:0002967)1.67988045
108Vitreoretinal degeneration (HP:0000655)1.67926537
109Hallux valgus (HP:0001822)1.67294989
110Uterine neoplasm (HP:0010784)1.66516893
111Obsessive-compulsive behavior (HP:0000722)1.66467419
112Thoracolumbar scoliosis (HP:0002944)1.66440708
113Exostoses (HP:0100777)1.65549517
114Large earlobe (HP:0009748)1.65468438
115* Hypoplasia of the maxilla (HP:0000327)1.64964359
116Broad long bones (HP:0005622)1.64280931
117Neonatal short-limb short stature (HP:0008921)1.63799869
118Scapular winging (HP:0003691)1.63517441
119Abnormality of the calcaneus (HP:0008364)1.63173460
120Cortical dysplasia (HP:0002539)1.62890860
121Type 1 muscle fiber predominance (HP:0003803)1.62742993
122Abnormality of the 2nd finger (HP:0004100)1.62221625
123Facial hemangioma (HP:0000329)1.61972960
124Broad finger (HP:0001500)1.61514147
125Long clavicles (HP:0000890)1.61116405
126Radial bowing (HP:0002986)1.60305851
127Muscle fiber inclusion bodies (HP:0100299)1.60107047
128Broad toe (HP:0001837)1.58604794
129Abnormality of oral frenula (HP:0000190)1.58531952
130Transitional cell carcinoma of the bladder (HP:0006740)1.58483191
131Limited elbow extension (HP:0001377)1.57787881
132Nemaline bodies (HP:0003798)1.57707767
133Abnormal vertebral ossification (HP:0100569)1.57404892
134Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.57192908
135Abnormality of the nasal septum (HP:0000419)1.56972941
136Abnormality of the distal phalanges of the toes (HP:0010182)1.56965530
137Tibial bowing (HP:0002982)1.56901578
138Calcaneovalgus deformity (HP:0001848)1.56703766
139Bladder neoplasm (HP:0009725)1.56632576
140Bladder carcinoma (HP:0002862)1.56632576
141Neoplasm of striated muscle (HP:0009728)1.56396189
142Bronchomalacia (HP:0002780)1.56377259
143Broad phalanx (HP:0006009)1.56059914
144Buphthalmos (HP:0000557)1.55676219
145Broad phalanges of the hand (HP:0009768)1.54693732
146Short middle phalanx of finger (HP:0005819)1.54628208
147Genetic anticipation (HP:0003743)1.54174781
148Flexion contracture of toe (HP:0005830)1.53849128
149Joint contractures involving the joints of the feet (HP:0100492)1.53849128
150Selective tooth agenesis (HP:0001592)1.53733421
151Hyperacusis (HP:0010780)1.53437297
152Abnormality of the epiphyses of the hand (HP:0005924)1.53394120
153Overgrowth (HP:0001548)1.52613422
154Limited hip movement (HP:0008800)1.52412361
155Broad hallux (HP:0010055)1.52165112
156Supernumerary ribs (HP:0005815)1.52161985
157Turricephaly (HP:0000262)1.52122624
158Bowel diverticulosis (HP:0005222)1.51934414
159Vertebral clefting (HP:0008428)1.51372981
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.51307951
161Arnold-Chiari malformation (HP:0002308)1.50503844
162Missing ribs (HP:0000921)1.50318919
163Natal tooth (HP:0000695)1.50124867
164Spinal cord lesions (HP:0100561)1.49904702
165Ankyloglossia (HP:0010296)1.49779824
166Rhabdomyosarcoma (HP:0002859)1.49083518

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.84102913
2CDK123.37118972
3PKN23.20417521
4LATS12.99790686
5EEF2K2.87437704
6AKT32.83351867
7MAP3K102.81973686
8TTN2.78916804
9PTK62.46502363
10RIPK12.24476875
11PDGFRA2.12034078
12STK102.11117688
13FRK2.01780181
14ACVR1B1.99083894
15OBSCN1.86336428
16PNCK1.81044768
17MAP3K31.79099074
18SGK21.79014047
19SCYL21.71154785
20CAMK1G1.63974741
21MKNK21.62361363
22RPS6KA41.61548134
23LRRK21.61485743
24* NLK1.54332353
25TGFBR21.53633305
26TNIK1.51192533
27FLT31.48206288
28TAF11.46928777
29MAP3K21.41950777
30EPHB21.41815581
31SGK31.37856448
32JAK31.33836081
33CDK61.32412573
34EPHA31.32376127
35SGK4941.31463969
36SGK2231.31463969
37STK31.29923030
38TRPM71.25822952
39CDK91.23335225
40YES11.22953372
41RPS6KB21.21042870
42BRSK21.19630916
43TGFBR11.19486083
44DMPK1.19368167
45MTOR1.18481045
46SIK11.18298608
47PIK3CG1.16142844
48EPHA21.15338495
49DDR21.15009248
50PAK41.14076201
51MKNK11.13232039
52MAP2K31.12617355
53CHUK1.10199654
54WNK11.10197760
55PDGFRB1.09309104
56PTK21.07762420
57ICK1.06372259
58MARK31.06181318
59FGFR41.05313160
60CASK1.05087308
61TYK21.04744447
62FGFR30.99705246
63PRPF4B0.95247654
64ERBB30.93745837
65NUAK10.89138370
66MAP3K140.88980428
67BRD40.88926508
68FGFR10.86668419
69NEK90.85708461
70FER0.85683439
71MARK20.84889369
72FGFR20.84657001
73MAP3K80.83564920
74BMX0.83459515
75LMTK20.80467373
76PAK20.78796700
77DYRK1B0.78449994
78NEK20.77305062
79ITK0.74456846
80ERN10.74202496
81CAMK1D0.73973490
82MAP4K10.73923942
83CDK40.73390810
84MET0.72202265
85STK380.70328912
86PIM10.69841666
87PASK0.67852692
88* MELK0.67421026
89ILK0.66881025
90WEE10.66180592
91ALK0.66052137
92EPHB10.65421838
93BLK0.64744194
94MAP3K70.64421681
95DYRK1A0.64074761
96JAK10.61804719
97CDK30.61733450
98LATS20.61376444
99MAPK70.61310209
100RPS6KB10.60196601
101DYRK30.59904160
102TYRO30.59799814
103BMPR1B0.59178328
104MAP3K40.58613140
105STK240.57811484
106RET0.56801987
107SGK10.56736723
108TBK10.54230455
109ZAK0.53866409
110STK38L0.52300769
111PRKD30.52288508
112GSK3A0.51969901
113CDC70.51091874
114* STK110.48327083
115CAMK40.48128355
116MAP3K60.47805781
117STK40.47228324
118GRK60.46386078
119KSR10.45517764
120PAK30.44790352
121ATM0.43558211
122CDC42BPA0.43144312
123ERBB20.42891186
124PRKAA20.42750869
125RPS6KA10.42270091
126CSK0.41733272
127TTK0.41646909
128MAPK100.41364010
129MOS0.40619441
130CDK70.40109836
131EGFR0.39622357
132INSR0.39528882
133KSR20.38728045
134PRKAA10.38545335
135PRKCI0.38301427
136MAP2K40.37845082
137HIPK20.37564667
138AURKB0.36937421
139MST40.36300735
140JAK20.34522506
141PRKD10.34414323
142TAOK10.33737987
143TEC0.31706053
144BCR0.31513445
145MAP3K130.31401916
146AKT10.28461551
147CHEK10.27844582
148IRAK10.26663180

Predicted pathways (KEGG)

RankGene SetZ-score
1* Adherens junction_Homo sapiens_hsa045202.28179145
2Small cell lung cancer_Homo sapiens_hsa052222.16220491
3Focal adhesion_Homo sapiens_hsa045101.88365455
4* Chronic myeloid leukemia_Homo sapiens_hsa052201.86863443
5MicroRNAs in cancer_Homo sapiens_hsa052061.85143687
6Proteoglycans in cancer_Homo sapiens_hsa052051.77493681
7Toxoplasmosis_Homo sapiens_hsa051451.72993206
8ECM-receptor interaction_Homo sapiens_hsa045121.71431811
9Leukocyte transendothelial migration_Homo sapiens_hsa046701.66588407
10* TGF-beta signaling pathway_Homo sapiens_hsa043501.65989343
11* Hippo signaling pathway_Homo sapiens_hsa043901.64293633
12* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62187146
13Viral myocarditis_Homo sapiens_hsa054161.61797223
14Basal cell carcinoma_Homo sapiens_hsa052171.56999610
15Leishmaniasis_Homo sapiens_hsa051401.50289422
16Amoebiasis_Homo sapiens_hsa051461.49890276
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48952209
18* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43338442
19Endometrial cancer_Homo sapiens_hsa052131.41286924
20Prostate cancer_Homo sapiens_hsa052151.41229720
21Osteoclast differentiation_Homo sapiens_hsa043801.36639616
22* Pancreatic cancer_Homo sapiens_hsa052121.33122203
23* Colorectal cancer_Homo sapiens_hsa052101.29771179
24Tight junction_Homo sapiens_hsa045301.29291428
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29227709
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.29184030
27TNF signaling pathway_Homo sapiens_hsa046681.27442116
28Renal cell carcinoma_Homo sapiens_hsa052111.27400904
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25963154
30Antigen processing and presentation_Homo sapiens_hsa046121.25264759
31* HTLV-I infection_Homo sapiens_hsa051661.23925766
32Dorso-ventral axis formation_Homo sapiens_hsa043201.21628221
33Thyroid cancer_Homo sapiens_hsa052161.21396089
34Insulin resistance_Homo sapiens_hsa049311.18470177
35Bladder cancer_Homo sapiens_hsa052191.18339210
36ErbB signaling pathway_Homo sapiens_hsa040121.18312067
37Choline metabolism in cancer_Homo sapiens_hsa052311.16898580
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16768915
39Inositol phosphate metabolism_Homo sapiens_hsa005621.16383359
40Notch signaling pathway_Homo sapiens_hsa043301.15669287
41mTOR signaling pathway_Homo sapiens_hsa041501.15535231
42* Pathways in cancer_Homo sapiens_hsa052001.14403605
43Circadian rhythm_Homo sapiens_hsa047101.13000376
44Acute myeloid leukemia_Homo sapiens_hsa052211.11952143
45Viral carcinogenesis_Homo sapiens_hsa052031.08338521
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05945331
47Legionellosis_Homo sapiens_hsa051341.05745491
48Melanogenesis_Homo sapiens_hsa049161.02804195
49Long-term potentiation_Homo sapiens_hsa047201.01704734
50Apoptosis_Homo sapiens_hsa042101.01499470
51Prolactin signaling pathway_Homo sapiens_hsa049171.00217035
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98471294
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97551619
54* FoxO signaling pathway_Homo sapiens_hsa040680.97432063
55Shigellosis_Homo sapiens_hsa051310.96923186
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95942304
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.95134114
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94846756
59T cell receptor signaling pathway_Homo sapiens_hsa046600.94222715
60Platelet activation_Homo sapiens_hsa046110.92899100
61Non-homologous end-joining_Homo sapiens_hsa034500.92431017
62Dilated cardiomyopathy_Homo sapiens_hsa054140.91964212
63* Hepatitis B_Homo sapiens_hsa051610.91643213
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.90704577
65Lysine degradation_Homo sapiens_hsa003100.89695449
66Protein digestion and absorption_Homo sapiens_hsa049740.89647108
67Insulin signaling pathway_Homo sapiens_hsa049100.89017657
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.88987426
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88697329
70B cell receptor signaling pathway_Homo sapiens_hsa046620.88613956
71Type II diabetes mellitus_Homo sapiens_hsa049300.88206756
72Hedgehog signaling pathway_Homo sapiens_hsa043400.87617239
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.85464572
74Non-small cell lung cancer_Homo sapiens_hsa052230.84285506
75Measles_Homo sapiens_hsa051620.83502647
76VEGF signaling pathway_Homo sapiens_hsa043700.83361800
77Nitrogen metabolism_Homo sapiens_hsa009100.83349479
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.83084766
79Rap1 signaling pathway_Homo sapiens_hsa040150.82274465
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81732876
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81151656
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81089408
83GnRH signaling pathway_Homo sapiens_hsa049120.80192909
84Herpes simplex infection_Homo sapiens_hsa051680.80140274
85Chemokine signaling pathway_Homo sapiens_hsa040620.79851781
86Melanoma_Homo sapiens_hsa052180.79752489
87Alcoholism_Homo sapiens_hsa050340.79355931
88Renin secretion_Homo sapiens_hsa049240.79176208
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79009869
90Long-term depression_Homo sapiens_hsa047300.78756253
91Glioma_Homo sapiens_hsa052140.78682310
92p53 signaling pathway_Homo sapiens_hsa041150.78545762
93* Cell cycle_Homo sapiens_hsa041100.76764724
94Hepatitis C_Homo sapiens_hsa051600.76654521
95Salmonella infection_Homo sapiens_hsa051320.75856604
96Glucagon signaling pathway_Homo sapiens_hsa049220.75589579
97Pertussis_Homo sapiens_hsa051330.75233076
98Influenza A_Homo sapiens_hsa051640.73568097
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73070169
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.72721765
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72198171
102Systemic lupus erythematosus_Homo sapiens_hsa053220.72153633
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71689587
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70789587
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70682752
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70444824
107HIF-1 signaling pathway_Homo sapiens_hsa040660.69365209
108mRNA surveillance pathway_Homo sapiens_hsa030150.68396744
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68122640
110Gap junction_Homo sapiens_hsa045400.67738528
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67461537
112Malaria_Homo sapiens_hsa051440.66396063
113* Wnt signaling pathway_Homo sapiens_hsa043100.66253409
114Axon guidance_Homo sapiens_hsa043600.66094265
115Estrogen signaling pathway_Homo sapiens_hsa049150.66072085
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66047877
117MAPK signaling pathway_Homo sapiens_hsa040100.65961615
118cAMP signaling pathway_Homo sapiens_hsa040240.65337391
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64556743
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63932266
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63727738
122AMPK signaling pathway_Homo sapiens_hsa041520.63065144
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62606711
124Thyroid hormone synthesis_Homo sapiens_hsa049180.62328861
125Cholinergic synapse_Homo sapiens_hsa047250.62316281
126Renin-angiotensin system_Homo sapiens_hsa046140.60666993
127RNA transport_Homo sapiens_hsa030130.60193641
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.59717978
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.59354476
130Ras signaling pathway_Homo sapiens_hsa040140.58834370
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58581699
132Primary immunodeficiency_Homo sapiens_hsa053400.57909970
133Tuberculosis_Homo sapiens_hsa051520.56782928
134ABC transporters_Homo sapiens_hsa020100.54963662
135Oxytocin signaling pathway_Homo sapiens_hsa049210.54868279
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49591801
137Fatty acid biosynthesis_Homo sapiens_hsa000610.49286620

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