SMAD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)3.93954177
2hippo signaling (GO:0035329)3.74596654
3nuclear pore complex assembly (GO:0051292)3.71443588
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.69123735
5nuclear pore organization (GO:0006999)3.51624488
6mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.45747555
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44657365
8midgut development (GO:0007494)3.42778293
9lymph vessel development (GO:0001945)3.41794236
10regulation of heart morphogenesis (GO:2000826)3.39640899
11negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.37709854
12paraxial mesoderm development (GO:0048339)3.35850350
13insulin-like growth factor receptor signaling pathway (GO:0048009)3.34934151
14outer ear morphogenesis (GO:0042473)3.32366640
15negative regulation of chondrocyte differentiation (GO:0032331)3.28028419
16cytoplasmic mRNA processing body assembly (GO:0033962)3.17757841
17lateral sprouting from an epithelium (GO:0060601)3.11743432
18mesenchymal-epithelial cell signaling (GO:0060638)3.11600279
19glucocorticoid receptor signaling pathway (GO:0042921)3.11342576
20mitotic sister chromatid cohesion (GO:0007064)3.09561766
21negative regulation of catenin import into nucleus (GO:0035414)3.06220747
22mesenchyme morphogenesis (GO:0072132)3.05263914
23cochlea morphogenesis (GO:0090103)3.03220114
24chondrocyte development (GO:0002063)3.01913228
25exocrine pancreas development (GO:0031017)3.00847487
26endocardial cushion morphogenesis (GO:0003203)3.00104773
27metanephric mesenchyme development (GO:0072075)3.00065360
28dorsal/ventral axis specification (GO:0009950)2.99177957
29vascular endothelial growth factor signaling pathway (GO:0038084)2.98409687
30embryonic retina morphogenesis in camera-type eye (GO:0060059)2.98187524
31renal system development (GO:0072001)2.97821629
32cell proliferation involved in metanephros development (GO:0072203)2.93136562
33regulation of mesenchymal cell proliferation (GO:0010464)2.92335673
34axon extension involved in axon guidance (GO:0048846)2.92254246
35neuron projection extension involved in neuron projection guidance (GO:1902284)2.92254246
36epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.92080648
37positive regulation of mesenchymal cell proliferation (GO:0002053)2.88996610
38G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.87109395
39polarized epithelial cell differentiation (GO:0030859)2.86191427
40collagen fibril organization (GO:0030199)2.86043421
41positive regulation of epithelial to mesenchymal transition (GO:0010718)2.84630130
42positive regulation of cartilage development (GO:0061036)2.84002030
43somite development (GO:0061053)2.83180542
44gastrulation with mouth forming second (GO:0001702)2.81519302
45regulation of secondary heart field cardioblast proliferation (GO:0003266)2.81002034
46regulation of cardioblast proliferation (GO:0003264)2.81002034
47positive regulation of glycogen biosynthetic process (GO:0045725)2.80594547
48Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80573164
49kidney mesenchyme development (GO:0072074)2.79667304
50regulation of centriole replication (GO:0046599)2.79344716
51regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.78949363
52anterior/posterior axis specification, embryo (GO:0008595)2.78649399
53proximal/distal pattern formation (GO:0009954)2.77092588
54glomerular filtration (GO:0003094)2.76055403
55negative regulation of cartilage development (GO:0061037)2.74698384
56interkinetic nuclear migration (GO:0022027)2.74534930
57positive regulation of hormone biosynthetic process (GO:0046886)2.73002623
58heart morphogenesis (GO:0003007)2.72272436
59notochord development (GO:0030903)2.72243354
60bone trabecula formation (GO:0060346)2.72001345
61regulation of establishment of planar polarity (GO:0090175)2.70388591
62hindlimb morphogenesis (GO:0035137)2.69733194
63chondrocyte proliferation (GO:0035988)2.67932460
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67580057
65embryonic foregut morphogenesis (GO:0048617)2.66823966
66embryonic skeletal joint morphogenesis (GO:0060272)2.66346797
67renal filtration (GO:0097205)2.66345081
68non-canonical Wnt signaling pathway (GO:0035567)2.66188957
69mesenchymal cell proliferation (GO:0010463)2.65942719
70cell surface receptor signaling pathway involved in heart development (GO:0061311)2.65149076
71regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.63663819
72regulation of catenin import into nucleus (GO:0035412)2.63595514
73positive regulation of catenin import into nucleus (GO:0035413)2.62379604
74embryonic camera-type eye morphogenesis (GO:0048596)2.62302259
75cell migration involved in heart development (GO:0060973)2.62093135
76sister chromatid segregation (GO:0000819)2.60525325
77sequestering of extracellular ligand from receptor (GO:0035581)2.59952486
78respiratory tube development (GO:0030323)2.58433049
79regulation of cartilage development (GO:0061035)2.57860759
80corticosteroid receptor signaling pathway (GO:0031958)2.57812959
81body morphogenesis (GO:0010171)2.57384322
82cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.56561022
83branching involved in ureteric bud morphogenesis (GO:0001658)2.56314353
84negative regulation of keratinocyte proliferation (GO:0010839)2.55071786
85regulation of DNA endoreduplication (GO:0032875)2.55049326
86protein localization to kinetochore (GO:0034501)2.54934631
87regulation of cardioblast differentiation (GO:0051890)2.54884284
88cell migration involved in sprouting angiogenesis (GO:0002042)2.52968914
89positive regulation of fatty acid beta-oxidation (GO:0032000)2.52717335
90embryonic cranial skeleton morphogenesis (GO:0048701)2.50520246
91regulation of sister chromatid cohesion (GO:0007063)2.50172816
92positive regulation of chondrocyte differentiation (GO:0032332)2.49107085
93regulation of transforming growth factor beta2 production (GO:0032909)2.49103290
94epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49039977
95regulation of RNA export from nucleus (GO:0046831)2.48880063
96regulation of chondrocyte differentiation (GO:0032330)2.48834100
97convergent extension (GO:0060026)2.48740925
98organ induction (GO:0001759)2.47370542
99protein heterotrimerization (GO:0070208)2.46911475
100regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.46512043
101cell proliferation involved in kidney development (GO:0072111)2.46106848
102regulation of centrosome cycle (GO:0046605)2.45430809
103pore complex assembly (GO:0046931)2.44213293
104regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.44064481
105embryonic viscerocranium morphogenesis (GO:0048703)2.43764437
106artery development (GO:0060840)2.43700024
107regulation of SMAD protein import into nucleus (GO:0060390)2.43639793
108chromatin remodeling at centromere (GO:0031055)2.43471608
109metaphase plate congression (GO:0051310)2.43259599
110DNA topological change (GO:0006265)2.42814759
111CENP-A containing nucleosome assembly (GO:0034080)2.42379535
112atrial septum morphogenesis (GO:0060413)2.42145170
113basement membrane organization (GO:0071711)2.42002184
114morphogenesis of an endothelium (GO:0003159)2.41300142
115endothelial tube morphogenesis (GO:0061154)2.41300142
116regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.41288584
117negative regulation of DNA repair (GO:0045738)2.40765169
118positive regulation of histone deacetylation (GO:0031065)2.40595371
119regulation of centrosome duplication (GO:0010824)2.39410406
120lung-associated mesenchyme development (GO:0060484)2.39266628
121mitotic chromosome condensation (GO:0007076)2.37469058
122mitotic metaphase plate congression (GO:0007080)2.36533113
123protein localization to chromosome, centromeric region (GO:0071459)2.35749794
124mitotic sister chromatid segregation (GO:0000070)2.34759486
125non-recombinational repair (GO:0000726)2.29835358
126double-strand break repair via nonhomologous end joining (GO:0006303)2.29835358
127kinetochore organization (GO:0051383)2.29057794
128regulation of non-canonical Wnt signaling pathway (GO:2000050)2.25297142
129regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.24967111
130prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.21096060
131anterior/posterior axis specification (GO:0009948)2.20408967
132ventricular cardiac muscle cell development (GO:0055015)2.17933552
133positive regulation of mitotic sister chromatid separation (GO:1901970)2.15986701
134positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.15986701
135positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.15986701
136retina vasculature morphogenesis in camera-type eye (GO:0061299)2.15983567
137morphogenesis of an epithelial sheet (GO:0002011)2.15655717
138lymphangiogenesis (GO:0001946)2.12690409
139DNA unwinding involved in DNA replication (GO:0006268)2.12674030
140ectodermal placode formation (GO:0060788)2.11846687
141mitotic cytokinesis (GO:0000281)2.11807226
142mitotic spindle organization (GO:0007052)2.11048280
143protein prenylation (GO:0018342)2.10699845
144prenylation (GO:0097354)2.10699845
145bundle of His cell to Purkinje myocyte communication (GO:0086069)2.09934292
146pre-miRNA processing (GO:0031054)2.08902746
147histone exchange (GO:0043486)2.08675657
148mesenchymal cell differentiation (GO:0048762)2.06946550
149embryonic axis specification (GO:0000578)2.05450996
150sister chromatid cohesion (GO:0007062)2.04216101
151otic vesicle formation (GO:0030916)2.03234664
152establishment of tissue polarity (GO:0007164)2.02739322
153establishment of planar polarity (GO:0001736)2.02739322
154response to X-ray (GO:0010165)1.99835623
155gap junction assembly (GO:0016264)1.99737895
156regulation of keratinocyte proliferation (GO:0010837)1.99663281
157branching involved in prostate gland morphogenesis (GO:0060442)1.99422997
158NLS-bearing protein import into nucleus (GO:0006607)1.98984941
159male genitalia development (GO:0030539)1.98865541
160histone-serine phosphorylation (GO:0035404)1.98380731
161spindle checkpoint (GO:0031577)1.97824529
162positive regulation of SMAD protein import into nucleus (GO:0060391)1.96508183
163somite rostral/caudal axis specification (GO:0032525)1.96207133
164UDP-N-acetylglucosamine metabolic process (GO:0006047)1.96130667
165genitalia morphogenesis (GO:0035112)1.95237189
166establishment of chromosome localization (GO:0051303)1.93821966
167primitive streak formation (GO:0090009)1.93129632
168regulation of growth hormone secretion (GO:0060123)1.90703690
169cytoskeleton-dependent cytokinesis (GO:0061640)1.90575837
170regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)1.90062626
171positive regulation of cardiac muscle cell proliferation (GO:0060045)1.89719495
172regulation of chromosome segregation (GO:0051983)1.89534197
173positive regulation of chromosome segregation (GO:0051984)1.89435019
174cellular protein complex localization (GO:0034629)1.89084825
175COPII vesicle coating (GO:0048208)1.88885683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.33263808
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.75304707
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20370025
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.19949734
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.19269563
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.18305479
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.16834167
8CLOCK_20551151_ChIP-Seq_293T_Human3.14631962
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.12234156
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.81282260
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.74203169
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59344113
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55752469
14FUS_26573619_Chip-Seq_HEK293_Human2.48476650
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31843947
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.30400618
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.24958249
18E2F7_22180533_ChIP-Seq_HELA_Human2.20569371
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.20477226
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.18175088
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.12877919
22EWS_26573619_Chip-Seq_HEK293_Human2.09767030
23* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.07823293
24TAF15_26573619_Chip-Seq_HEK293_Human1.95581797
25* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94073378
26GBX2_23144817_ChIP-Seq_PC3_Human1.87110985
27FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.86271476
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84329021
29* ISL1_27105846_Chip-Seq_CPCs_Mouse1.83418091
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.80469878
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79921840
32BRD4_25478319_ChIP-Seq_HGPS_Human1.79551925
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78776375
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77438549
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77118704
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.72475711
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.71385448
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70506532
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68505929
40* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66624086
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64612583
42MYC_22102868_ChIP-Seq_BL_Human1.62417926
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60725551
44ELK1_19687146_ChIP-ChIP_HELA_Human1.59777080
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57939868
46P300_19829295_ChIP-Seq_ESCs_Human1.57600849
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56443926
48TCF4_18268006_ChIP-ChIP_LS174T_Human1.55216516
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.52054426
50IGF1R_20145208_ChIP-Seq_DFB_Human1.51661728
51AR_21909140_ChIP-Seq_LNCAP_Human1.50747922
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47620979
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47201689
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46053460
55* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46030886
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44000120
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43817882
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43446127
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43252234
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41714268
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41226016
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40964901
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.40727440
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40702401
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40382298
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.38830842
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38186650
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37775524
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.37719274
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37718830
71SMAD4_21799915_ChIP-Seq_A2780_Human1.36305666
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.34320715
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33614282
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33614282
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.33563502
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.33563502
77* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32792753
78CJUN_26792858_Chip-Seq_BT549_Human1.32110517
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31336226
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31142363
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.30092796
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25564913
83* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25294281
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24017126
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23795208
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23686367
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.23239202
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22682971
89* TCF7_22412390_ChIP-Seq_EML_Mouse1.21490915
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.21358710
91CHD1_26751641_Chip-Seq_LNCaP_Human1.21014644
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20426787
93KDM2B_26808549_Chip-Seq_DND41_Human1.20413682
94ZNF274_21170338_ChIP-Seq_K562_Hela1.19923538
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19640982
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19153892
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.19123108
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18334696
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.17455199
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.17401365
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16326560
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16185233
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16072414
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16072414
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14804642
106SOX9_26525672_Chip-Seq_HEART_Mouse1.14752631
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14587620
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.14441421
109VDR_22108803_ChIP-Seq_LS180_Human1.13906173
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13294693
111PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13194448
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12186337
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11268803
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11101064
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10812003
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10529898
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.09817321
118E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09408118
119STAT3_23295773_ChIP-Seq_U87_Human1.08787217
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08539643
121FOXO3_23340844_ChIP-Seq_DLD1_Human1.08303138
122MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.08199781
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07840387
124TP53_16413492_ChIP-PET_HCT116_Human1.07277208
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06263343
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05831548
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05617809
128EZH2_27294783_Chip-Seq_NPCs_Mouse1.05223575
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04909690
130MYC_18555785_ChIP-Seq_MESCs_Mouse1.03946507
131* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03201857
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03000905
133CBX2_27304074_Chip-Seq_ESCs_Mouse1.02971115
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02877445
135PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01918132
136WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01530939
137SOX17_20123909_ChIP-Seq_XEN_Mouse1.01364916
138PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01174721
139YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01041475
140MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99817783
141RNF2_27304074_Chip-Seq_NSC_Mouse0.99294514
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98719126
143EED_16625203_ChIP-ChIP_MESCs_Mouse0.97981039
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97739362
145E2F1_18555785_Chip-Seq_ESCs_Mouse0.97656078
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97291674
147KDM2B_26808549_Chip-Seq_K562_Human0.96955597
148TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96604748
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95663946
150SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95450956
151ESR2_21235772_ChIP-Seq_MCF-7_Human0.95302353
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95276503
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94638297
154CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94095612
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93908285
156AR_25329375_ChIP-Seq_VCAP_Human0.92327087
157* TP53_18474530_ChIP-ChIP_U2OS_Human0.89537636
158TCF4_23295773_ChIP-Seq_U87_Human0.89501889
159SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89370089
160ER_23166858_ChIP-Seq_MCF-7_Human0.88795515
161UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87278465
162NANOG_16153702_ChIP-ChIP_HESCs_Human0.86720575
163SOX2_16153702_ChIP-ChIP_HESCs_Human0.86001895
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84722263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.48627598
2MP0009053_abnormal_anal_canal2.89731963
3MP0006054_spinal_hemorrhage2.85672356
4MP0008438_abnormal_cutaneous_collagen2.83196961
5MP0000537_abnormal_urethra_morphology2.63645392
6MP0005503_abnormal_tendon_morphology2.61513922
7MP0010030_abnormal_orbit_morphology2.50217047
8MP0008057_abnormal_DNA_replication2.38326738
9MP0004272_abnormal_basement_membrane2.36577323
10MP0010368_abnormal_lymphatic_system2.36089714
11MP0005275_abnormal_skin_tensile2.32635950
12* MP0003385_abnormal_body_wall2.04487034
13MP0001879_abnormal_lymphatic_vessel2.01720885
14MP0002249_abnormal_larynx_morphology1.98118201
15MP0003122_maternal_imprinting1.91090615
16MP0009250_abnormal_appendicular_skeleto1.90003870
17MP0003942_abnormal_urinary_system1.83786068
18MP0010234_abnormal_vibrissa_follicle1.79598959
19MP0002282_abnormal_trachea_morphology1.78944819
20MP0009697_abnormal_copulation1.78298015
21MP0000428_abnormal_craniofacial_morphol1.76458322
22MP0003937_abnormal_limbs/digits/tail_de1.75642389
23MP0000733_abnormal_muscle_development1.75481774
24MP0010094_abnormal_chromosome_stability1.75208968
25MP0003115_abnormal_respiratory_system1.72970108
26MP0009384_cardiac_valve_regurgitation1.72503420
27MP0005187_abnormal_penis_morphology1.67233187
28MP0002938_white_spotting1.65371718
29MP0000049_abnormal_middle_ear1.64385131
30* MP0003935_abnormal_craniofacial_develop1.60910814
31MP0002932_abnormal_joint_morphology1.56133046
32MP0002233_abnormal_nose_morphology1.52542449
33MP0000534_abnormal_ureter_morphology1.52129852
34MP0005248_abnormal_Harderian_gland1.52104418
35MP0004957_abnormal_blastocyst_morpholog1.51016778
36MP0003941_abnormal_skin_development1.50210923
37MP0003755_abnormal_palate_morphology1.48515112
38MP0003279_aneurysm1.46492763
39MP0005623_abnormal_meninges_morphology1.41584251
40MP0008932_abnormal_embryonic_tissue1.40007202
41MP0005508_abnormal_skeleton_morphology1.38085941
42MP0001958_emphysema1.37491660
43MP0003123_paternal_imprinting1.33496742
44MP0003077_abnormal_cell_cycle1.32951139
45MP0010352_gastrointestinal_tract_polyps1.31957752
46MP0005076_abnormal_cell_differentiation1.30915948
47MP0003693_abnormal_embryo_hatching1.30895213
48MP0010678_abnormal_skin_adnexa1.30701963
49MP0004197_abnormal_fetal_growth/weight/1.28866695
50MP0002896_abnormal_bone_mineralization1.28840746
51MP0005257_abnormal_intraocular_pressure1.28541393
52MP0003121_genomic_imprinting1.27038243
53* MP0000767_abnormal_smooth_muscle1.26459220
54MP0003283_abnormal_digestive_organ1.26301016
55MP0000432_abnormal_head_morphology1.25575428
56MP0000566_synostosis1.25493817
57MP0002108_abnormal_muscle_morphology1.25391747
58MP0009780_abnormal_chondrocyte_physiolo1.25124312
59MP0003111_abnormal_nucleus_morphology1.24913472
60MP0003567_abnormal_fetal_cardiomyocyte1.24877303
61MP0000383_abnormal_hair_follicle1.22675810
62MP0000762_abnormal_tongue_morphology1.22671975
63MP0001849_ear_inflammation1.22067069
64MP0002116_abnormal_craniofacial_bone1.21363554
65MP0000163_abnormal_cartilage_morphology1.21027992
66MP0002109_abnormal_limb_morphology1.20323380
67MP0002098_abnormal_vibrissa_morphology1.19997252
68MP0001299_abnormal_eye_distance/1.18437691
69MP0003136_yellow_coat_color1.17830909
70MP0001293_anophthalmia1.17816028
71MP0002234_abnormal_pharynx_morphology1.15689502
72MP0008058_abnormal_DNA_repair1.13705353
73MP0000579_abnormal_nail_morphology1.12880296
74MP0003300_gastrointestinal_ulcer1.12003275
75MP0003950_abnormal_plasma_membrane1.11759924
76MP0002060_abnormal_skin_morphology1.11590715
77MP0006292_abnormal_olfactory_placode1.10533107
78* MP0001672_abnormal_embryogenesis/_devel1.09783988
79* MP0005380_embryogenesis_phenotype1.09783988
80* MP0002925_abnormal_cardiovascular_devel1.09370037
81MP0002092_abnormal_eye_morphology1.09236085
82MP0002697_abnormal_eye_size1.08059902
83MP0002115_abnormal_skeleton_extremities1.07153456
84MP0002111_abnormal_tail_morphology1.06912033
85* MP0003984_embryonic_growth_retardation1.06831039
86MP0000647_abnormal_sebaceous_gland1.06248208
87MP0000462_abnormal_digestive_system1.05908873
88MP0004134_abnormal_chest_morphology1.05412264
89MP0001270_distended_abdomen1.03084047
90MP0006072_abnormal_retinal_apoptosis1.02652815
91* MP0003119_abnormal_digestive_system1.00763555
92* MP0001697_abnormal_embryo_size1.00318194
93MP0000569_abnormal_digit_pigmentation1.00282227
94MP0002009_preneoplasia0.97771338
95* MP0002084_abnormal_developmental_patter0.97406757
96* MP0002113_abnormal_skeleton_development0.94330576
97MP0001915_intracranial_hemorrhage0.93833928
98MP0003718_maternal_effect0.92526752
99* MP0002085_abnormal_embryonic_tissue0.92449481
100MP0008877_abnormal_DNA_methylation0.91671339
101MP0000516_abnormal_urinary_system0.91628859
102MP0005367_renal/urinary_system_phenotyp0.91628859
103MP0002877_abnormal_melanocyte_morpholog0.91523414
104* MP0002128_abnormal_blood_circulation0.91496449
105MP0010307_abnormal_tumor_latency0.91011562
106MP0010630_abnormal_cardiac_muscle0.90441520
107MP0006138_congestive_heart_failure0.89776036
108MP0003890_abnormal_embryonic-extraembry0.89718909
109MP0005408_hypopigmentation0.89538020
110MP0001730_embryonic_growth_arrest0.89447494
111MP0002114_abnormal_axial_skeleton0.89336656
112MP0004215_abnormal_myocardial_fiber0.89285709
113MP0009703_decreased_birth_body0.88972980
114MP0004808_abnormal_hematopoietic_stem0.88556854
115MP0000427_abnormal_hair_cycle0.88435544
116MP0005391_vision/eye_phenotype0.87229837
117MP0002177_abnormal_outer_ear0.86357622
118MP0009278_abnormal_bone_marrow0.86278224
119MP0002089_abnormal_postnatal_growth/wei0.86166716
120MP0001661_extended_life_span0.85908035
121MP0009672_abnormal_birth_weight0.85880395
122MP0002160_abnormal_reproductive_system0.85825702
123MP0003566_abnormal_cell_adhesion0.85752699
124MP0005171_absent_coat_pigmentation0.85349527
125MP0001346_abnormal_lacrimal_gland0.85040394
126MP0001286_abnormal_eye_development0.84826583
127MP0003091_abnormal_cell_migration0.84061676
128* MP0003861_abnormal_nervous_system0.83915012
129MP0003943_abnormal_hepatobiliary_system0.83740637
130* MP0002088_abnormal_embryonic_growth/wei0.83703168
131* MP0002086_abnormal_extraembryonic_tissu0.83244889
132* MP0000266_abnormal_heart_morphology0.82535296
133MP0005023_abnormal_wound_healing0.82231523
134MP0000778_abnormal_nervous_system0.81158584
135MP0000631_abnormal_neuroendocrine_gland0.80721395
136MP0008007_abnormal_cellular_replicative0.80603825
137MP0000350_abnormal_cell_proliferation0.79096541
138MP0000013_abnormal_adipose_tissue0.78313595
139MP0001177_atelectasis0.78243156
140MP0005197_abnormal_uvea_morphology0.76975538

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.60348409
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.60348409
3Abnormality of the 4th metacarpal (HP:0010012)4.15993689
4Protrusio acetabuli (HP:0003179)3.49686907
5Shallow orbits (HP:0000586)3.41231174
6Renal duplication (HP:0000075)3.01421612
7Subacute progressive viral hepatitis (HP:0006572)2.84385150
8Broad metatarsal (HP:0001783)2.83922872
9Aortic aneurysm (HP:0004942)2.79925531
10Cerebral aneurysm (HP:0004944)2.63016063
11Hyperacusis (HP:0010780)2.59848698
12Asymmetry of the thorax (HP:0001555)2.51866112
13Volvulus (HP:0002580)2.47286987
14Intestinal atresia (HP:0011100)2.46290124
15Bladder diverticulum (HP:0000015)2.45243297
16Premature rupture of membranes (HP:0001788)2.43489442
17Ankle contracture (HP:0006466)2.40952345
18Lymphangioma (HP:0100764)2.40826228
19Rectal prolapse (HP:0002035)2.40236466
20Mesomelia (HP:0003027)2.38644413
21Neonatal short-limb short stature (HP:0008921)2.38021156
22Deviation of the hallux (HP:0010051)2.36941196
23Aortic dissection (HP:0002647)2.35592971
24Papillary thyroid carcinoma (HP:0002895)2.34893287
25Mitral valve prolapse (HP:0001634)2.31979774
26Midline defect of the nose (HP:0004122)2.27932609
27Broad thumb (HP:0011304)2.27806150
28Hallux valgus (HP:0001822)2.25305276
29Abnormality of the parietal bone (HP:0002696)2.20928412
30Wide anterior fontanel (HP:0000260)2.20814721
31Hepatoblastoma (HP:0002884)2.20191964
32Renovascular hypertension (HP:0100817)2.19992398
33Hypoplastic ischia (HP:0003175)2.13764690
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11972450
35Broad toe (HP:0001837)2.11659756
36Enlarged penis (HP:0000040)2.11208440
37Chromsome breakage (HP:0040012)2.10928241
38Hypoplastic labia majora (HP:0000059)2.10875154
39Exostoses (HP:0100777)2.07445880
40Atrophic scars (HP:0001075)2.06714500
41Hematochezia (HP:0002573)2.05600882
42Coronal craniosynostosis (HP:0004440)2.05079871
43Increased nuchal translucency (HP:0010880)2.04051860
44Elfin facies (HP:0004428)2.03731041
45Spinal cord lesions (HP:0100561)2.02867447
46Syringomyelia (HP:0003396)2.02867447
47Long eyelashes (HP:0000527)2.02139425
48Short 5th finger (HP:0009237)2.01426940
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01170719
50Flat cornea (HP:0007720)2.01105914
51Gastrointestinal atresia (HP:0002589)1.99932751
52Preaxial foot polydactyly (HP:0001841)1.97641271
53Broad long bones (HP:0005622)1.97246267
54Macroorchidism (HP:0000053)1.97167856
55Broad phalanx (HP:0006009)1.96484919
56Broad phalanges of the hand (HP:0009768)1.95743364
57Bowel diverticulosis (HP:0005222)1.94061132
58Narrow palate (HP:0000189)1.92527331
59Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.92391384
60Vitreoretinal degeneration (HP:0000655)1.92011065
61Abnormality of the ischium (HP:0003174)1.91754649
62Broad finger (HP:0001500)1.91025632
63Abnormality of the distal phalanx of the thumb (HP:0009617)1.89514079
64Buphthalmos (HP:0000557)1.89289523
65Diastasis recti (HP:0001540)1.88599017
66Abnormality of the fingertips (HP:0001211)1.88339507
67Morphological abnormality of the middle ear (HP:0008609)1.87779399
68Abnormality of the labia majora (HP:0012881)1.87515200
69Abnormal lung lobation (HP:0002101)1.86508557
70Aneurysm (HP:0002617)1.84918309
71Cutaneous syndactyly (HP:0012725)1.83328099
72Skull defect (HP:0001362)1.81693411
73Camptodactyly of toe (HP:0001836)1.80073885
74Bifid tongue (HP:0010297)1.79406159
75Broad palm (HP:0001169)1.79405224
76Colon cancer (HP:0003003)1.79158711
77Soft skin (HP:0000977)1.76379006
78Overgrowth (HP:0001548)1.75743847
79Esophageal atresia (HP:0002032)1.75439642
80Disproportionate tall stature (HP:0001519)1.73792637
81Broad hallux (HP:0010055)1.73756643
82Trigonocephaly (HP:0000243)1.72824008
83Short middle phalanx of the 5th finger (HP:0004220)1.72378318
84Type 1 muscle fiber predominance (HP:0003803)1.72163777
85Nephroblastoma (Wilms tumor) (HP:0002667)1.71933390
86Abnormal biliary tract morphology (HP:0012440)1.71628500
87Germ cell neoplasia (HP:0100728)1.71515306
88Embryonal renal neoplasm (HP:0011794)1.70594329
89Scapular winging (HP:0003691)1.70515061
90Broad ribs (HP:0000885)1.69250601
91Abnormality of the 2nd finger (HP:0004100)1.68796970
92Deep philtrum (HP:0002002)1.68464233
93Blue sclerae (HP:0000592)1.67969842
94Follicular hyperkeratosis (HP:0007502)1.67498060
95Abnormality of the diencephalon (HP:0010662)1.66303199
96Thyroid carcinoma (HP:0002890)1.65945989
97Neoplasm of the oral cavity (HP:0100649)1.65378079
98Absent eyebrow (HP:0002223)1.65364663
99Ulnar bowing (HP:0003031)1.65297411
100Joint laxity (HP:0001388)1.64156289
101Overriding aorta (HP:0002623)1.63679660
102Dilatation of the ascending aorta (HP:0005111)1.63072290
103Cortical dysplasia (HP:0002539)1.62973228
104Meckel diverticulum (HP:0002245)1.61849332
105Hypoplasia of the maxilla (HP:0000327)1.61838980
106Advanced eruption of teeth (HP:0006288)1.61616620
107Visceral angiomatosis (HP:0100761)1.61154932
108Medulloblastoma (HP:0002885)1.60909568
109Abnormality of dentin (HP:0010299)1.60594583
110Rhizomelia (HP:0008905)1.60293325
111Mildly elevated creatine phosphokinase (HP:0008180)1.60037149
112Abnormality of the peritoneum (HP:0002585)1.60027746
113Glioma (HP:0009733)1.59957720
114Bicuspid aortic valve (HP:0001647)1.58898611
115Radial bowing (HP:0002986)1.58079147
116Abnormal pancreas size (HP:0012094)1.57120552
117Fragile skin (HP:0001030)1.56930768
118Bell-shaped thorax (HP:0001591)1.55684869
119Overlapping toe (HP:0001845)1.55554786
120Absent radius (HP:0003974)1.54812932
121Abnormality of the nasal septum (HP:0000419)1.54028407
122Mitral regurgitation (HP:0001653)1.53402747
123Fibular hypoplasia (HP:0003038)1.53358603
124Neoplasm of the small intestine (HP:0100833)1.53103834
125Natal tooth (HP:0000695)1.52840519
126Cutaneous finger syndactyly (HP:0010554)1.52547875
127Facial cleft (HP:0002006)1.52312541
128Omphalocele (HP:0001539)1.51918457
129Proximal tubulopathy (HP:0000114)1.51884673
130Abnormality of the ileum (HP:0001549)1.51751444
131Right ventricular cardiomyopathy (HP:0011663)1.50844732
132Missing ribs (HP:0000921)1.50724721
133Aplasia involving bones of the upper limbs (HP:0009823)1.50574968
134Aplasia of the phalanges of the hand (HP:0009802)1.50574968
135Aplasia involving bones of the extremities (HP:0009825)1.50574968
136Anophthalmia (HP:0000528)1.49558065
137Ectopic kidney (HP:0000086)1.49286038
138Astrocytoma (HP:0009592)1.49073260
139Abnormality of the astrocytes (HP:0100707)1.49073260
140Genital tract atresia (HP:0001827)1.48591712
141Vaginal atresia (HP:0000148)1.47107898
142Microglossia (HP:0000171)1.47029938
143Aplasia/Hypoplasia of the uvula (HP:0010293)1.46234863
144Rhabdomyosarcoma (HP:0002859)1.45797782
145Abnormality of chromosome stability (HP:0003220)1.45091537
146Biliary tract neoplasm (HP:0100574)1.44737891
147Absent eyelashes (HP:0000561)1.44635412
148Abnormality of the duodenum (HP:0002246)1.43516881
149Short middle phalanx of finger (HP:0005819)1.42642646
150Aplasia involving forearm bones (HP:0009822)1.42293051
151Absent forearm bone (HP:0003953)1.42293051
152Gastrointestinal carcinoma (HP:0002672)1.41763293
153Malignant gastrointestinal tract tumors (HP:0006749)1.41763293
154Ependymoma (HP:0002888)1.39003495
155Septo-optic dysplasia (HP:0100842)1.38909944
156Aplasia/Hypoplasia of the fibula (HP:0006492)1.38129775
157Large earlobe (HP:0009748)1.35900512
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.35787648
159Pulmonic stenosis (HP:0001642)1.35754091
160Benign neoplasm of the central nervous system (HP:0100835)1.35427679
161High anterior hairline (HP:0009890)1.35130535
162Bifid scrotum (HP:0000048)1.34221790
163Cystic hygroma (HP:0000476)1.33039405
164Abnormality of the labia minora (HP:0012880)1.32269541
165Abnormality of the dental root (HP:0006486)1.32104321
166Taurodontia (HP:0000679)1.32104321
167Abnormality of permanent molar morphology (HP:0011071)1.32104321
168Renal hypoplasia (HP:0000089)1.31430850
169Short tibia (HP:0005736)1.30841054
170Aplasia/Hypoplasia of the sternum (HP:0006714)1.30807735
171Anal stenosis (HP:0002025)1.30739345
172Abnormality of molar (HP:0011077)1.30208924
173Abnormality of molar morphology (HP:0011070)1.30208924
174Hypospadias (HP:0000047)1.29620586
175Limited hip movement (HP:0008800)1.29465635
176Vertebral arch anomaly (HP:0008438)1.28848176
177Aqueductal stenosis (HP:0002410)1.28824680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.85432264
2TRIB33.60271707
3PKN23.13770486
4PNCK2.89696541
5PDGFRA2.83851411
6BRSK22.48401807
7MAP3K102.30551794
8WEE12.29272499
9PTK62.21560437
10TTN2.20718236
11STK38L2.20383485
12TGFBR12.10432758
13RIPK12.09953842
14EPHB22.09847322
15FGFR22.04931772
16TSSK62.04031425
17DDR21.99468870
18BMPR1B1.95232217
19SIK11.95192723
20STK391.88341834
21EEF2K1.87294137
22PBK1.86342619
23EPHA31.73877744
24CASK1.73772193
25MAP3K31.70102104
26ERBB31.69863127
27EIF2AK31.64239770
28MKNK11.63455521
29NEK11.59097050
30FGFR11.58562161
31TIE11.57267458
32FGFR31.57218631
33CDK121.53101341
34PDGFRB1.49686580
35AKT31.48438215
36FRK1.48140393
37WNK31.46683190
38STK31.46421266
39PLK41.45571784
40CAMK1D1.45280779
41PASK1.43053734
42BUB11.42772894
43CDK61.37742889
44MAP3K21.37348061
45PLK31.36124273
46MST41.32391121
47STK241.28709163
48NUAK11.27249606
49BCR1.26386815
50MTOR1.26275426
51PAK21.24265678
52RPS6KB21.23932133
53DMPK1.23269420
54CAMK1G1.22716166
55TRIM281.21112620
56MKNK21.19252155
57LRRK21.18193030
58FLT31.17723519
59TGFBR21.16933801
60CDC71.14681583
61RPS6KA41.14638478
62NEK91.11636007
63ACVR1B1.08149781
64DYRK1B1.07909890
65BRD41.05394661
66SGK31.00802062
67PAK41.00007158
68SRPK10.98066577
69WNK40.97147126
70EIF2AK10.96565486
71TAF10.95850019
72PLK10.95100785
73PTK20.95061776
74MAP3K40.95004154
75SGK20.91417991
76ERN10.91118334
77FER0.89929940
78ERBB20.89447020
79BRSK10.89149865
80MET0.88931106
81MST1R0.88772897
82FGFR40.87675003
83CHEK20.87564939
84TNIK0.87322923
85INSRR0.83536398
86CSNK1G10.81150470
87ILK0.80806852
88KDR0.76298661
89ICK0.74052750
90TYRO30.73636839
91PLK20.73211514
92CDK90.72665145
93LATS20.71962928
94PRKD30.71351468
95CLK10.69638554
96NLK0.67456652
97OBSCN0.65387055
98NEK20.64412085
99BMX0.64214172
100RET0.62923623
101MAP2K30.61441542
102CHEK10.61355435
103CHUK0.61202512
104MELK0.60692472
105HIPK20.58583328
106PRKCH0.58472396
107MAP3K90.58184409
108TTK0.57503136
109ROCK10.56500698
110YES10.56422166
111CSNK1A1L0.55491032
112CDK70.55015731
113CDK40.53866192
114SCYL20.53643850
115MAP3K70.53582108
116PAK30.53011753
117GSK3A0.52635645
118MAP4K20.51702310
119PIK3CA0.51672581
120KSR10.51013860
121CDK80.50845432
122CDK30.50618393
123CSNK1G20.49181726
124SGK4940.48912907
125SGK2230.48912907
126CAMK40.48308900
127TRPM70.48213956
128EIF2AK20.47323139
129PRKCE0.45993914
130PRKAA20.44964423
131ZAK0.44622816
132AKT10.44463535
133NTRK10.43718790
134CSNK1E0.43225044
135CSNK1G30.40357617
136IGF1R0.40183716
137PRKD20.37881841
138ATR0.36557282
139DYRK30.36526063
140GRK10.36276716
141PRKD10.35822353
142ATM0.35768287
143PRKDC0.35533334
144EPHB10.35119907
145CDK10.34909948
146ERBB40.34675645
147AKT20.32901356
148AURKB0.32490429
149LMTK20.32093937

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.94960762
2ECM-receptor interaction_Homo sapiens_hsa045122.48308775
3Adherens junction_Homo sapiens_hsa045202.40499657
4Non-homologous end-joining_Homo sapiens_hsa034502.36966603
5Mismatch repair_Homo sapiens_hsa034302.30933730
6Focal adhesion_Homo sapiens_hsa045102.23135776
7Hippo signaling pathway_Homo sapiens_hsa043902.17368188
8Hedgehog signaling pathway_Homo sapiens_hsa043402.11809139
9Protein export_Homo sapiens_hsa030602.09715292
10Small cell lung cancer_Homo sapiens_hsa052222.05755997
11MicroRNAs in cancer_Homo sapiens_hsa052062.04263606
12Lysine degradation_Homo sapiens_hsa003101.98436933
13Proteoglycans in cancer_Homo sapiens_hsa052051.97850804
14Chronic myeloid leukemia_Homo sapiens_hsa052201.83408832
15* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.81268696
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80901390
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80279054
18Notch signaling pathway_Homo sapiens_hsa043301.78380453
19* TGF-beta signaling pathway_Homo sapiens_hsa043501.78261216
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73699747
21Fanconi anemia pathway_Homo sapiens_hsa034601.73656197
22Basal transcription factors_Homo sapiens_hsa030221.70485197
23Nucleotide excision repair_Homo sapiens_hsa034201.67056485
24DNA replication_Homo sapiens_hsa030301.55946153
25Wnt signaling pathway_Homo sapiens_hsa043101.51372542
26One carbon pool by folate_Homo sapiens_hsa006701.50303552
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48302675
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47991462
29Homologous recombination_Homo sapiens_hsa034401.47030340
30Endometrial cancer_Homo sapiens_hsa052131.45995362
31Protein digestion and absorption_Homo sapiens_hsa049741.42224107
32Prostate cancer_Homo sapiens_hsa052151.41490109
33Viral myocarditis_Homo sapiens_hsa054161.41230604
34Colorectal cancer_Homo sapiens_hsa052101.40311263
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38826477
36Cell cycle_Homo sapiens_hsa041101.35604004
37Steroid biosynthesis_Homo sapiens_hsa001001.35023435
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32405981
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32323169
40Pathways in cancer_Homo sapiens_hsa052001.31110782
41Phototransduction_Homo sapiens_hsa047441.30484119
42HTLV-I infection_Homo sapiens_hsa051661.29605051
43Vitamin B6 metabolism_Homo sapiens_hsa007501.29275707
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27051428
45Tight junction_Homo sapiens_hsa045301.25341011
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25015372
47Insulin resistance_Homo sapiens_hsa049311.24748236
48Dilated cardiomyopathy_Homo sapiens_hsa054141.22927862
49Nitrogen metabolism_Homo sapiens_hsa009101.21086926
50Circadian rhythm_Homo sapiens_hsa047101.20771991
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20467230
52Melanogenesis_Homo sapiens_hsa049161.17047967
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.15270666
54Pyruvate metabolism_Homo sapiens_hsa006201.14690301
55Pancreatic cancer_Homo sapiens_hsa052121.14387955
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12084194
57Melanoma_Homo sapiens_hsa052181.10932639
58Axon guidance_Homo sapiens_hsa043601.10741280
59mRNA surveillance pathway_Homo sapiens_hsa030151.10036187
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09349695
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05449439
62Bladder cancer_Homo sapiens_hsa052191.04364654
63Folate biosynthesis_Homo sapiens_hsa007901.03598531
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03483086
65Renal cell carcinoma_Homo sapiens_hsa052111.03418599
66mTOR signaling pathway_Homo sapiens_hsa041501.02566373
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.02268378
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01845469
69Spliceosome_Homo sapiens_hsa030401.01189767
70Oocyte meiosis_Homo sapiens_hsa041140.99471161
71Thyroid cancer_Homo sapiens_hsa052160.97995229
72Amoebiasis_Homo sapiens_hsa051460.97485752
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95520707
74AMPK signaling pathway_Homo sapiens_hsa041520.95513090
75Glioma_Homo sapiens_hsa052140.94979024
76Systemic lupus erythematosus_Homo sapiens_hsa053220.93422276
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93224268
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92539883
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.92382855
80FoxO signaling pathway_Homo sapiens_hsa040680.92124590
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91930932
82Platelet activation_Homo sapiens_hsa046110.91830122
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.91511688
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89754024
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89184375
86Non-small cell lung cancer_Homo sapiens_hsa052230.89169929
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88501474
88Rap1 signaling pathway_Homo sapiens_hsa040150.86857540
89RNA polymerase_Homo sapiens_hsa030200.79087691
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78739452
91Insulin signaling pathway_Homo sapiens_hsa049100.75767217
92Viral carcinogenesis_Homo sapiens_hsa052030.74997170
93Dorso-ventral axis formation_Homo sapiens_hsa043200.73025782
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72251319
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71737885
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.71628975
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69637515
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68635437
99Fatty acid metabolism_Homo sapiens_hsa012120.68415018
100Base excision repair_Homo sapiens_hsa034100.67699919
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67479566
102Sulfur metabolism_Homo sapiens_hsa009200.66325226
103Prolactin signaling pathway_Homo sapiens_hsa049170.66120981
104Fatty acid degradation_Homo sapiens_hsa000710.65738124
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63463984
106Glucagon signaling pathway_Homo sapiens_hsa049220.63307156
107p53 signaling pathway_Homo sapiens_hsa041150.62838042
108Toxoplasmosis_Homo sapiens_hsa051450.61430254
109Estrogen signaling pathway_Homo sapiens_hsa049150.61352894
110Butanoate metabolism_Homo sapiens_hsa006500.60579553
111Hepatitis B_Homo sapiens_hsa051610.60050828
112Sphingolipid metabolism_Homo sapiens_hsa006000.58520567
113Fatty acid elongation_Homo sapiens_hsa000620.57987847
114Selenocompound metabolism_Homo sapiens_hsa004500.57893723
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57721712
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57302637
117Purine metabolism_Homo sapiens_hsa002300.57185080
118Gap junction_Homo sapiens_hsa045400.54837475
119Acute myeloid leukemia_Homo sapiens_hsa052210.53491034
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51098477
121N-Glycan biosynthesis_Homo sapiens_hsa005100.51094391
122Arginine and proline metabolism_Homo sapiens_hsa003300.49065129
123Ovarian steroidogenesis_Homo sapiens_hsa049130.48906241
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.47447084
125PPAR signaling pathway_Homo sapiens_hsa033200.47085268
126Alcoholism_Homo sapiens_hsa050340.45602482
127HIF-1 signaling pathway_Homo sapiens_hsa040660.44938044
128beta-Alanine metabolism_Homo sapiens_hsa004100.44212058
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43167025
130Type II diabetes mellitus_Homo sapiens_hsa049300.41632642
131VEGF signaling pathway_Homo sapiens_hsa043700.40222771
132Pyrimidine metabolism_Homo sapiens_hsa002400.40115138
133RNA transport_Homo sapiens_hsa030130.39909468
134Fatty acid biosynthesis_Homo sapiens_hsa000610.39728363
135Arginine biosynthesis_Homo sapiens_hsa002200.39715455
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.37722951
137Propanoate metabolism_Homo sapiens_hsa006400.37655214
138Retinol metabolism_Homo sapiens_hsa008300.37645304
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37447198
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37320409
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37298459
142Thyroid hormone synthesis_Homo sapiens_hsa049180.36816150
143Glutathione metabolism_Homo sapiens_hsa004800.36121068
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36017606
145RNA degradation_Homo sapiens_hsa030180.35413451
146ErbB signaling pathway_Homo sapiens_hsa040120.34760840
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.34335371

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