SMAD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)4.72647837
2surfactant homeostasis (GO:0043129)4.53010637
3endothelial cell morphogenesis (GO:0001886)4.17657692
4regulation of endothelial cell differentiation (GO:0045601)4.11051425
5glomerular visceral epithelial cell development (GO:0072015)4.10443293
6morphogenesis of an endothelium (GO:0003159)4.10125716
7endothelial tube morphogenesis (GO:0061154)4.10125716
8blood vessel maturation (GO:0001955)4.01756692
9lymphangiogenesis (GO:0001946)4.01157027
10wound healing, spreading of epidermal cells (GO:0035313)3.95450708
11cell migration involved in sprouting angiogenesis (GO:0002042)3.86198070
12atrial septum morphogenesis (GO:0060413)3.84724290
13lymph vessel development (GO:0001945)3.82949235
14retina vasculature morphogenesis in camera-type eye (GO:0061299)3.78231469
15cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.77552231
16glomerular epithelial cell development (GO:0072310)3.74684061
17positive regulation of p38MAPK cascade (GO:1900745)3.71468443
18embryonic heart tube development (GO:0035050)3.69434062
19blood vessel endothelial cell migration (GO:0043534)3.66914715
20positive regulation of endothelial cell differentiation (GO:0045603)3.65935108
21endocardial cushion development (GO:0003197)3.64320501
22pericardium development (GO:0060039)3.63036460
23basement membrane organization (GO:0071711)3.62613701
24positive regulation of odontogenesis (GO:0042482)3.59793170
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.55268082
26axon extension involved in axon guidance (GO:0048846)3.55268082
27positive regulation of osteoblast proliferation (GO:0033690)3.55211377
28glomerular basement membrane development (GO:0032836)3.54227318
29cell adhesion mediated by integrin (GO:0033627)3.52058815
30polarized epithelial cell differentiation (GO:0030859)3.47216664
31epithelial cell-cell adhesion (GO:0090136)3.45118702
32lung vasculature development (GO:0060426)3.42322472
33regulation of p38MAPK cascade (GO:1900744)3.34463505
34regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.33736670
35regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.33278819
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.31206073
37chemical homeostasis within a tissue (GO:0048875)3.29966366
38endothelium development (GO:0003158)3.29393961
39establishment of epithelial cell polarity (GO:0090162)3.28165537
40apoptotic cell clearance (GO:0043277)3.22348912
41notochord development (GO:0030903)3.21970359
42respiratory tube development (GO:0030323)3.21423335
43renal filtration (GO:0097205)3.20733875
44cardiac septum morphogenesis (GO:0060411)3.18641477
45venous blood vessel morphogenesis (GO:0048845)3.18597456
46mesodermal cell differentiation (GO:0048333)3.18510781
47pathway-restricted SMAD protein phosphorylation (GO:0060389)3.18195819
48heart valve morphogenesis (GO:0003179)3.16742476
49regulation of glucocorticoid metabolic process (GO:0031943)3.14573693
50neural crest cell development (GO:0014032)3.11304323
51chondrocyte proliferation (GO:0035988)3.10074589
52establishment of apical/basal cell polarity (GO:0035089)3.09756358
53endocardial cushion morphogenesis (GO:0003203)3.08665062
54protein heterotrimerization (GO:0070208)3.07243915
55adherens junction assembly (GO:0034333)3.06495324
56regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.04596594
57ventricular cardiac muscle cell development (GO:0055015)3.03833250
58cell migration involved in heart development (GO:0060973)3.03791299
59hippo signaling (GO:0035329)3.03313270
60cardiac muscle cell proliferation (GO:0060038)3.02448706
61artery morphogenesis (GO:0048844)3.01683768
62morphogenesis of an epithelial sheet (GO:0002011)3.01275248
63regulation of vasculogenesis (GO:2001212)2.98633406
64negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.96764621
65vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.95723470
66apoptotic process involved in morphogenesis (GO:0060561)2.95251258
67patterning of blood vessels (GO:0001569)2.94775138
68positive regulation of cartilage development (GO:0061036)2.90507522
69blood vessel remodeling (GO:0001974)2.87069426
70wound healing, spreading of cells (GO:0044319)2.86902950
71negative regulation of fibrinolysis (GO:0051918)2.85734499
72collagen fibril organization (GO:0030199)2.84092474
73bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83991122
74regulation of cardioblast differentiation (GO:0051890)2.83614425
75vasculogenesis (GO:0001570)2.83221806
76embryonic skeletal joint morphogenesis (GO:0060272)2.82328203
77cell-substrate junction assembly (GO:0007044)2.82163765
78cardiac myofibril assembly (GO:0055003)2.81696220
79atrioventricular valve morphogenesis (GO:0003181)2.81579639
80endodermal cell differentiation (GO:0035987)2.81399759
81regulation of tight junction assembly (GO:2000810)2.80756668
82artery development (GO:0060840)2.79350098
83mesenchyme morphogenesis (GO:0072132)2.78326154
84outflow tract septum morphogenesis (GO:0003148)2.78226380
85ventricular septum morphogenesis (GO:0060412)2.77793051
86glomerular filtration (GO:0003094)2.77377366
87endothelial cell differentiation (GO:0045446)2.76905802
88heart trabecula formation (GO:0060347)2.76416308
89midgut development (GO:0007494)2.74923811
90gap junction assembly (GO:0016264)2.74500237
91regulation of heart morphogenesis (GO:2000826)2.72495476
92heart valve formation (GO:0003188)2.71665554
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71404948
94fibroblast migration (GO:0010761)2.71227353
95negative regulation of vascular permeability (GO:0043116)2.70549775
96blood vessel morphogenesis (GO:0048514)2.70090921
97positive regulation of BMP signaling pathway (GO:0030513)2.69121095
98regulation of transforming growth factor beta2 production (GO:0032909)2.67112509
99embryonic foregut morphogenesis (GO:0048617)2.66868368
100cellular protein complex localization (GO:0034629)2.66743859
101regulation of hippo signaling (GO:0035330)2.65925783
102positive regulation of cardiac muscle cell proliferation (GO:0060045)2.65842696
103embryonic process involved in female pregnancy (GO:0060136)2.64276051
104branching involved in salivary gland morphogenesis (GO:0060445)2.63804427
105positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.62892807
106epoxygenase P450 pathway (GO:0019373)2.62405217
107striated muscle cell proliferation (GO:0014855)2.61422512
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.60265802
109cell proliferation involved in kidney development (GO:0072111)2.60224460
110substrate adhesion-dependent cell spreading (GO:0034446)2.60105362
111SMAD protein signal transduction (GO:0060395)2.59027751
112mesenchymal cell development (GO:0014031)2.58284616
113cardiac chamber formation (GO:0003207)2.57754424
114regulation of steroid hormone biosynthetic process (GO:0090030)2.57171061
115trabecula formation (GO:0060343)2.56394412
116positive regulation of stem cell differentiation (GO:2000738)2.54883464
117negative regulation of cell fate specification (GO:0009996)2.54857922
118positive regulation of endothelial cell apoptotic process (GO:2000353)2.54768090
119protein localization to cell surface (GO:0034394)2.54487043
120semaphorin-plexin signaling pathway (GO:0071526)2.54221128
121endothelial cell chemotaxis (GO:0035767)2.53659233
122cardiac muscle tissue morphogenesis (GO:0055008)2.53656152
123paraxial mesoderm development (GO:0048339)2.53417003
124endothelial cell migration (GO:0043542)2.52483329
125positive regulation of vasculogenesis (GO:2001214)2.51561009
126positive regulation of histone deacetylation (GO:0031065)2.51070401
127negative regulation of fatty acid transport (GO:2000192)2.50754222
128mesoderm formation (GO:0001707)2.49482977
129positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49406877
130nuclear pore complex assembly (GO:0051292)2.49306564
131sarcomere organization (GO:0045214)2.49021701
132lung lobe morphogenesis (GO:0060463)2.48785931
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48092279
134regulation of SMAD protein import into nucleus (GO:0060390)2.47958307
135substrate-dependent cell migration (GO:0006929)2.47892913
136cell-substrate adherens junction assembly (GO:0007045)2.47589390
137focal adhesion assembly (GO:0048041)2.47589390
138bone trabecula formation (GO:0060346)2.46109160
139stress fiber assembly (GO:0043149)2.44867580
140plasma membrane repair (GO:0001778)2.44710656
141negative regulation of myoblast differentiation (GO:0045662)2.44427802
142heart morphogenesis (GO:0003007)2.43729999
143coronary vasculature morphogenesis (GO:0060977)2.43256441
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.42762266
145desmosome organization (GO:0002934)2.42379156
146renal system development (GO:0072001)2.42364078
147positive regulation of astrocyte differentiation (GO:0048711)2.41794577
148cartilage morphogenesis (GO:0060536)2.41642520
149negative regulation of hormone metabolic process (GO:0032351)2.40675144
150endocrine hormone secretion (GO:0060986)2.40520099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.17439428
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.74976927
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.98920120
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.72677878
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.58881228
6* CLOCK_20551151_ChIP-Seq_293T_Human3.36307594
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.29663466
8E2F7_22180533_ChIP-Seq_HELA_Human2.98367865
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69841749
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.45320197
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.44332723
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43641832
13* FOXM1_23109430_ChIP-Seq_U2OS_Human2.38331514
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.37775451
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37608191
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.36421585
17* LXR_22158963_ChIP-Seq_LIVER_Mouse2.33443737
18* ELK3_25401928_ChIP-Seq_HUVEC_Human2.29329617
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.21378479
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.17183509
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.08330005
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05138439
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.96050267
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.93669501
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.93317277
26* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88451339
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.84288948
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.84041975
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82185301
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.79435130
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.76349489
32* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73697348
33AR_21909140_ChIP-Seq_LNCAP_Human1.73092384
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.70027325
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.70027325
36* KDM2B_26808549_Chip-Seq_K562_Human1.69191383
37* RACK7_27058665_Chip-Seq_MCF-7_Human1.66840787
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61901129
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61901129
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61901129
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57247823
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52989015
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.52930600
44ZNF263_19887448_ChIP-Seq_K562_Human1.52255599
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52236091
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.52204461
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50549596
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50490067
49* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50469448
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48949878
51CJUN_26792858_Chip-Seq_BT549_Human1.48240020
52CDX2_20551321_ChIP-Seq_CACO-2_Human1.46055413
53VDR_21846776_ChIP-Seq_THP-1_Human1.46027323
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45746518
55* TP53_20018659_ChIP-ChIP_R1E_Mouse1.44267302
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43389434
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43212184
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.42440424
59* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41698865
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39425861
61ATF3_27146783_Chip-Seq_COLON_Human1.38429603
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38377205
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36860119
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.36484273
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36318688
66* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35494105
67* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35494105
68* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35481495
69* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35481495
70* SOX2_20726797_ChIP-Seq_SW620_Human1.35164148
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34144016
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32802596
73* LXR_22292898_ChIP-Seq_THP-1_Human1.32795412
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31055656
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30570208
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28325966
77* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26860812
78UBF1/2_26484160_Chip-Seq_HMECs_Human1.25666739
79* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24233421
80* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23431813
81* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22861726
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22159432
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.21014839
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20528512
85* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20235453
86* BRD4_25478319_ChIP-Seq_HGPS_Human1.19391328
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17094745
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17089951
89GATA4_25053715_ChIP-Seq_YYC3_Human1.16317068
90* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16196949
91* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16089638
92GATA6_25053715_ChIP-Seq_YYC3_Human1.14845522
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14441026
94* KDM2B_26808549_Chip-Seq_JURKAT_Human1.13557301
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13221814
96* RING1B_27294783_Chip-Seq_NPCs_Mouse1.12868416
97MYC_22102868_ChIP-Seq_BL_Human1.12825451
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12161141
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11990092
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11520482
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11237446
102* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10841097
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10053786
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09880708
105* ISL1_27105846_Chip-Seq_CPCs_Mouse1.09422420
106* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08228766
107* KDM2B_26808549_Chip-Seq_DND41_Human1.08197320
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07677423
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07071614
110* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06112436
111* NCOR1_26117541_ChIP-Seq_K562_Human1.04704901
112* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04349184
113* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03688612
114TP53_22127205_ChIP-Seq_IMR90_Human1.03479412
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03339260
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03017493
117GATA1_22025678_ChIP-Seq_K562_Human1.01678770
118* CREB1_26743006_Chip-Seq_LNCaP_Human1.01403563
119TP63_19390658_ChIP-ChIP_HaCaT_Human0.98807822
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98049107
121JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97991217
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97599212
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97443050
124* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96770319
125* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96759253
126CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95642948
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95006720
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94237093
129MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93749510
130* TCF7_22412390_ChIP-Seq_EML_Mouse0.93716187
131* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93038834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.03315760
2MP0008438_abnormal_cutaneous_collagen3.89376322
3MP0003705_abnormal_hypodermis_morpholog3.76016854
4MP0004272_abnormal_basement_membrane3.31204003
5MP0001879_abnormal_lymphatic_vessel2.99960469
6MP0001958_emphysema2.77578494
7MP0003279_aneurysm2.69744471
8MP0005275_abnormal_skin_tensile2.53568697
9MP0003566_abnormal_cell_adhesion2.28955336
10MP0005623_abnormal_meninges_morphology2.12969658
11MP0004084_abnormal_cardiac_muscle2.12581458
12MP0005503_abnormal_tendon_morphology2.06869433
13MP0010030_abnormal_orbit_morphology1.98006381
14MP0000767_abnormal_smooth_muscle1.96312548
15MP0003828_pulmonary_edema1.90232987
16MP0006054_spinal_hemorrhage1.89337708
17MP0003283_abnormal_digestive_organ1.88707824
18MP0005167_abnormal_blood-brain_barrier1.87959334
19MP0000537_abnormal_urethra_morphology1.86719111
20MP0004233_abnormal_muscle_weight1.84993444
21MP0009053_abnormal_anal_canal1.75560997
22MP0002877_abnormal_melanocyte_morpholog1.66422202
23MP0005023_abnormal_wound_healing1.64547421
24MP0006138_congestive_heart_failure1.64279463
25MP0009384_cardiac_valve_regurgitation1.53519975
26MP0010352_gastrointestinal_tract_polyps1.53504811
27MP0002139_abnormal_hepatobiliary_system1.48488106
28MP0000003_abnormal_adipose_tissue1.47235047
29MP0002697_abnormal_eye_size1.42031380
30MP0002295_abnormal_pulmonary_circulatio1.41811063
31MP0000013_abnormal_adipose_tissue1.41568797
32MP0005409_darkened_coat_color1.40459386
33MP0005360_urolithiasis1.38754694
34MP0002138_abnormal_hepatobiliary_system1.38234028
35MP0003091_abnormal_cell_migration1.37944054
36MP0000516_abnormal_urinary_system1.35367320
37MP0005367_renal/urinary_system_phenotyp1.35367320
38MP0003567_abnormal_fetal_cardiomyocyte1.31923047
39MP0010630_abnormal_cardiac_muscle1.30796437
40MP0001661_extended_life_span1.30592723
41MP0003937_abnormal_limbs/digits/tail_de1.28679524
42MP0000534_abnormal_ureter_morphology1.26318152
43MP0003385_abnormal_body_wall1.25959523
44MP0002108_abnormal_muscle_morphology1.25682503
45* MP0001544_abnormal_cardiovascular_syste1.25318360
46* MP0005385_cardiovascular_system_phenoty1.25318360
47* MP0002128_abnormal_blood_circulation1.25268346
48MP0003941_abnormal_skin_development1.20330316
49MP0000462_abnormal_digestive_system1.17342467
50* MP0002925_abnormal_cardiovascular_devel1.16938238
51* MP0001614_abnormal_blood_vessel1.16751588
52MP0004858_abnormal_nervous_system1.15791711
53MP0005380_embryogenesis_phenotype1.15535287
54MP0001672_abnormal_embryogenesis/_devel1.15535287
55MP0003724_increased_susceptibility_to1.14783543
56MP0005508_abnormal_skeleton_morphology1.14737240
57MP0003950_abnormal_plasma_membrane1.14658975
58MP0009278_abnormal_bone_marrow1.12347442
59MP0005330_cardiomyopathy1.10658959
60MP0008775_abnormal_heart_ventricle1.09619602
61MP0002092_abnormal_eye_morphology1.07742767
62MP0003252_abnormal_bile_duct1.07662827
63MP0000049_abnormal_middle_ear1.07627824
64MP0002282_abnormal_trachea_morphology1.07525202
65MP0004782_abnormal_surfactant_physiolog1.06743813
66MP0003115_abnormal_respiratory_system1.06597255
67MP0005076_abnormal_cell_differentiation1.05718339
68MP0005197_abnormal_uvea_morphology1.04875479
69MP0004036_abnormal_muscle_relaxation1.04838346
70MP0000762_abnormal_tongue_morphology1.04479941
71MP0002084_abnormal_developmental_patter1.03927952
72MP0002060_abnormal_skin_morphology1.03404754
73MP0000343_altered_response_to1.03317750
74MP0003942_abnormal_urinary_system1.02756501
75MP0000733_abnormal_muscle_development0.98952983
76MP0008875_abnormal_xenobiotic_pharmacok0.97286007
77MP0005085_abnormal_gallbladder_physiolo0.95534936
78MP0005257_abnormal_intraocular_pressure0.94697198
79MP0002972_abnormal_cardiac_muscle0.94432637
80MP0001730_embryonic_growth_arrest0.93034886
81MP0000749_muscle_degeneration0.92573221
82MP0002009_preneoplasia0.91816185
83* MP0000266_abnormal_heart_morphology0.91366896
84MP0000759_abnormal_skeletal_muscle0.90901888
85MP0001915_intracranial_hemorrhage0.90774842
86MP0003300_gastrointestinal_ulcer0.90732054
87MP0004087_abnormal_muscle_fiber0.90249169
88MP0002085_abnormal_embryonic_tissue0.89751395
89MP0001175_abnormal_lung_morphology0.88587742
90* MP0000249_abnormal_blood_vessel0.87742067
91MP0009250_abnormal_appendicular_skeleto0.87714391
92MP0005083_abnormal_biliary_tract0.86982203
93MP0005670_abnormal_white_adipose0.86833060
94MP0004130_abnormal_muscle_cell0.86210895
95MP0003191_abnormal_cellular_cholesterol0.85429343
96MP0005165_increased_susceptibility_to0.84830847
97MP0002133_abnormal_respiratory_system0.83886607
98MP0005388_respiratory_system_phenotype0.83886607
99MP0005666_abnormal_adipose_tissue0.83609972
100MP0000432_abnormal_head_morphology0.81143640
101MP0002111_abnormal_tail_morphology0.81089273
102MP0005187_abnormal_penis_morphology0.80886611
103MP0002086_abnormal_extraembryonic_tissu0.80643896
104MP0002896_abnormal_bone_mineralization0.79549759
105MP0005365_abnormal_bile_salt0.79538444
106MP0002088_abnormal_embryonic_growth/wei0.79362110
107MP0003935_abnormal_craniofacial_develop0.79322292
108MP0003453_abnormal_keratinocyte_physiol0.79235173
109MP0004185_abnormal_adipocyte_glucose0.79013539
110MP0003984_embryonic_growth_retardation0.78956718
111* MP0005595_abnormal_vascular_smooth0.78824230
112MP0001243_abnormal_dermal_layer0.78091796
113MP0000163_abnormal_cartilage_morphology0.77998076
114MP0003755_abnormal_palate_morphology0.77622837
115MP0005058_abnormal_lysosome_morphology0.77231064
116MP0001299_abnormal_eye_distance/0.76519254
117MP0000750_abnormal_muscle_regeneration0.76022480
118MP0002080_prenatal_lethality0.74690641
119MP0002116_abnormal_craniofacial_bone0.74680058
120MP0002249_abnormal_larynx_morphology0.74029932
121MP0001849_ear_inflammation0.73826605
122MP0001697_abnormal_embryo_size0.73157314
123MP0002127_abnormal_cardiovascular_syste0.72532244
124MP0005164_abnormal_response_to0.71781523
125MP0005375_adipose_tissue_phenotype0.71045548
126MP0000428_abnormal_craniofacial_morphol0.70412573
127MP0000751_myopathy0.69839039
128MP0002135_abnormal_kidney_morphology0.69586943
129MP0005248_abnormal_Harderian_gland0.68996082
130MP0002115_abnormal_skeleton_extremities0.68473030
131MP0005390_skeleton_phenotype0.68456138
132MP0002932_abnormal_joint_morphology0.67736402
133MP0010329_abnormal_lipoprotein_level0.67154440
134MP0009840_abnormal_foam_cell0.66379661

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.51204252
2Premature rupture of membranes (HP:0001788)4.86420546
3Cerebral aneurysm (HP:0004944)4.12995109
4Hematochezia (HP:0002573)3.91459194
5Aortic aneurysm (HP:0004942)3.84574503
6Aortic dissection (HP:0002647)3.78738720
7Polycythemia (HP:0001901)3.73442848
8Shallow orbits (HP:0000586)3.52407899
9Broad metatarsal (HP:0001783)3.27347260
10Ankle contracture (HP:0006466)3.15605186
11Esophageal varix (HP:0002040)3.11196596
12Right ventricular cardiomyopathy (HP:0011663)3.06100260
13Atrophic scars (HP:0001075)2.99688568
14Increased connective tissue (HP:0009025)2.99044516
15Deep venous thrombosis (HP:0002625)2.98997578
16Spontaneous hematomas (HP:0007420)2.94179450
17Peritonitis (HP:0002586)2.91806470
18Aneurysm (HP:0002617)2.90982906
19Mitral valve prolapse (HP:0001634)2.90125973
20Hyperacusis (HP:0010780)2.69206248
21Mesangial abnormality (HP:0001966)2.68266621
22Broad face (HP:0000283)2.64598740
23Pulmonary artery stenosis (HP:0004415)2.60596130
24Camptodactyly of toe (HP:0001836)2.59788439
25Bladder diverticulum (HP:0000015)2.56893678
26Lymphangioma (HP:0100764)2.53653408
27Dilatation of the ascending aorta (HP:0005111)2.53051339
28Vascular tortuosity (HP:0004948)2.50011737
29Nonimmune hydrops fetalis (HP:0001790)2.49418119
30Elbow flexion contracture (HP:0002987)2.45622342
31Osteolytic defects of the hand bones (HP:0009699)2.45244604
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.45244604
33Long toe (HP:0010511)2.41683342
34Ulnar bowing (HP:0003031)2.35757367
35Visceral angiomatosis (HP:0100761)2.34804557
36Blue sclerae (HP:0000592)2.30507661
37Interstitial pulmonary disease (HP:0006530)2.30002723
38Soft skin (HP:0000977)2.29011513
39Spinal rigidity (HP:0003306)2.28879682
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.28726106
41Sparse lateral eyebrow (HP:0005338)2.25749578
42Wormian bones (HP:0002645)2.22927367
43Hemangiomatosis (HP:0007461)2.22896393
44Ventricular tachycardia (HP:0004756)2.21071861
45Mitral regurgitation (HP:0001653)2.19516166
46Renal duplication (HP:0000075)2.17140933
47Abnormality of the nasal mucosa (HP:0000433)2.17020856
48Arterial tortuosity (HP:0005116)2.16285575
49Abnormality of dentin (HP:0010299)2.16117565
50Conjunctival telangiectasia (HP:0000524)2.15068891
51Fragile skin (HP:0001030)2.12532691
52Subacute progressive viral hepatitis (HP:0006572)2.10891037
53Overgrowth (HP:0001548)2.10768909
54Cervical subluxation (HP:0003308)2.09882763
55Mildly elevated creatine phosphokinase (HP:0008180)2.09136968
56Neonatal short-limb short stature (HP:0008921)2.08896893
57Abnormality of the distal phalanges of the toes (HP:0010182)2.07521567
58Abnormality of the left ventricular outflow tract (HP:0011103)2.06899044
59Subaortic stenosis (HP:0001682)2.06899044
60Focal segmental glomerulosclerosis (HP:0000097)2.06244664
61Lipoatrophy (HP:0100578)2.05942670
62Muscle fiber splitting (HP:0003555)2.05071794
63Type 1 muscle fiber predominance (HP:0003803)2.04638596
64Biconcave vertebral bodies (HP:0004586)2.04530324
65Partial duplication of the phalanx of hand (HP:0009999)2.02210729
66Chondrocalcinosis (HP:0000934)2.02002412
67Abnormality of the 2nd finger (HP:0004100)2.01304651
68Wide anterior fontanel (HP:0000260)2.00447572
69Disproportionate tall stature (HP:0001519)1.99929077
70Morphological abnormality of the middle ear (HP:0008609)1.98973324
71Neonatal death (HP:0003811)1.98796850
72Preauricular pit (HP:0004467)1.98503330
73Periauricular skin pits (HP:0100277)1.98503330
74Vertebral compression fractures (HP:0002953)1.98426541
75Patent foramen ovale (HP:0001655)1.96339439
76Asymmetry of the thorax (HP:0001555)1.95617246
77Coronal craniosynostosis (HP:0004440)1.95439582
78Joint contractures involving the joints of the feet (HP:0100492)1.95155530
79Flexion contracture of toe (HP:0005830)1.95155530
80Wrist flexion contracture (HP:0001239)1.94687845
81Rectal prolapse (HP:0002035)1.94117640
82Distal lower limb amyotrophy (HP:0008944)1.94109757
83Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93788870
84Sudden death (HP:0001699)1.93660643
85Persistence of primary teeth (HP:0006335)1.93540161
86Partial duplication of thumb phalanx (HP:0009944)1.93433283
87Thin ribs (HP:0000883)1.92113934
88Abnormality of the fetal cardiovascular system (HP:0010948)1.91373865
89Abnormal umbilical cord blood vessels (HP:0011403)1.91373865
90Single umbilical artery (HP:0001195)1.91373865
91Bowed forearm bones (HP:0003956)1.90178057
92Bowing of the arm (HP:0006488)1.90178057
93Abnormal ossification of hand bones (HP:0005921)1.89342944
94Abnormality of the peritoneum (HP:0002585)1.88882744
95Abnormality of the umbilical cord (HP:0010881)1.88137733
96Mitral stenosis (HP:0001718)1.87904552
97Pulmonary hypertension (HP:0002092)1.87883620
98Dislocated radial head (HP:0003083)1.87005071
99Abnormality of the nasal septum (HP:0000419)1.86610877
100Abnormal cartilage morphology (HP:0002763)1.86508751
101Abnormal ventriculo-arterial connection (HP:0011563)1.85634714
102Transposition of the great arteries (HP:0001669)1.85634714
103Abnormal connection of the cardiac segments (HP:0011545)1.85634714
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83815331
105Short 4th metacarpal (HP:0010044)1.83815331
106Abnormality of the acetabulum (HP:0003170)1.83723215
107Hypoplasia of the iris (HP:0007676)1.83379144
108Ectopia lentis (HP:0001083)1.82999823
109Growth hormone excess (HP:0000845)1.82983529
110Nephritis (HP:0000123)1.82969114
111Abnormality of the phalanges of the hallux (HP:0010057)1.82853416
112Abnormality of Sharpey fibers (HP:0100685)1.82728799
113Hyporeflexia of lower limbs (HP:0002600)1.81481372
114Hyperextensible skin (HP:0000974)1.81456718
115Thin bony cortex (HP:0002753)1.81249267
116Abnormal delivery (HP:0001787)1.80247432
117Difficulty climbing stairs (HP:0003551)1.79451382
118Facial shape deformation (HP:0011334)1.79431661
119Potter facies (HP:0002009)1.79431661
120Short hallux (HP:0010109)1.79311080
121Abnormality of carpal bone ossification (HP:0006257)1.78888841
122Deviation of the thumb (HP:0009603)1.78802647
123Joint laxity (HP:0001388)1.78737000
124Aplasia cutis congenita (HP:0001057)1.77142613
125Syringomyelia (HP:0003396)1.76430018
126Spinal cord lesions (HP:0100561)1.76430018
127Turricephaly (HP:0000262)1.75491677
128Short clavicles (HP:0000894)1.74954306
129Micronodular cirrhosis (HP:0001413)1.74901760
130Shawl scrotum (HP:0000049)1.74647707
131Radial bowing (HP:0002986)1.74301470
132Skull defect (HP:0001362)1.74265630
133Long eyelashes (HP:0000527)1.73541717
134Cavernous hemangioma (HP:0001048)1.73046242
135Arnold-Chiari malformation (HP:0002308)1.73004682
136Mucosal telangiectasiae (HP:0100579)1.72277776
137Abnormality of the radial head (HP:0003995)1.72054266
138Preaxial foot polydactyly (HP:0001841)1.71992188
139Stridor (HP:0010307)1.71703550
140Aplasia involving bones of the extremities (HP:0009825)1.71018707
141Aplasia involving bones of the upper limbs (HP:0009823)1.71018707
142Aplasia of the phalanges of the hand (HP:0009802)1.71018707
143Venous abnormality (HP:0002624)1.70270258
144Flat acetabular roof (HP:0003180)1.69039906
145Short nail (HP:0001799)1.69020514
146Genu recurvatum (HP:0002816)1.68898872
147Glomerulosclerosis (HP:0000096)1.68797311
148Midface retrusion (HP:0011800)1.68059552
149Increased variability in muscle fiber diameter (HP:0003557)1.67595897
150Venous insufficiency (HP:0005293)1.66747668
151Aplasia/Hypoplasia of the hallux (HP:0008362)1.65814712
152Abnormality of the 4th metacarpal (HP:0010012)1.65735347
153Hemorrhage of the eye (HP:0011885)1.65365403
154Bell-shaped thorax (HP:0001591)1.61490995
155Deviation of the hallux (HP:0010051)1.61262796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.52691531
2TGFBR23.35404497
3TRIB33.30953590
4TTN3.03640267
5CDK123.02855222
6PKN22.97468633
7KDR2.94943855
8EPHB22.78174201
9MYLK2.46743583
10ERN12.31974643
11DDR22.29562366
12PDGFRA2.18497847
13RIPK12.16453050
14PAK42.13942569
15LATS12.13078762
16TGFBR12.07002679
17PTK61.98390262
18MAP2K31.97813875
19IRAK31.89859268
20SMG11.75657089
21MAP3K31.73168212
22ILK1.54121505
23LRRK21.53422541
24FER1.44660395
25MAP3K101.44570857
26LATS21.43374014
27TESK11.39261940
28BCKDK1.39085117
29MAP3K71.33431187
30MELK1.29220275
31PAK21.27383271
32SIK11.24880935
33MAP2K21.22188929
34NTRK11.22142051
35EPHA31.22083629
36PTK2B1.21542415
37DMPK1.18683262
38EPHB11.18003341
39PTK21.17258352
40FLT31.16006439
41MAP3K111.09630121
42TRPM71.04312906
43ERBB41.04104171
44FGFR41.02352007
45CAMK1G0.98634201
46STK100.97727231
47STK30.97471899
48PAK30.97068894
49MET0.94579030
50EPHA20.93251870
51PRKD30.91555334
52NEK90.90920267
53BRD40.90502620
54STK390.89805958
55BMX0.86141466
56PRPF4B0.85774572
57LMTK20.83795557
58MAP3K60.83722004
59CDK80.83693625
60MAPK110.82251633
61PIM20.80047215
62PRKG20.79323499
63AKT30.79220767
64EEF2K0.78533692
65TESK20.78475553
66CDK60.76507822
67DAPK30.75843289
68STK38L0.74474177
69NEK20.73600720
70PDK20.73385423
71RPS6KB20.71522214
72MTOR0.70412354
73TLK10.70262803
74PRKD10.70086744
75CAMK1D0.69300808
76CSK0.68879752
77PBK0.68254839
78SCYL20.67540774
79NME20.66309814
80PDGFRB0.66149748
81CDK40.61238161
82MAPKAPK30.61186911
83WNK40.59539983
84MAP3K80.59237306
85TBK10.57660747
86PRKD20.56567020
87RPS6KL10.55785768
88RPS6KC10.55785768
89ROCK10.55467373
90CDK70.55056004
91FGFR10.53862141
92MAPK70.53752827
93AURKB0.53641187
94CDC42BPA0.53242059
95MAP2K10.52783227
96RPS6KA40.52539768
97MAP3K20.51977524
98RPS6KA60.51945505
99TAOK10.50805963
100LIMK10.50510204
101PIK3CA0.50232822
102MARK20.46203746
103ABL20.45206822
104TTK0.44516956
105FRK0.42505362
106NEK60.42138388
107PRKAA20.42121642
108ICK0.42000256
109PRKAA10.40859094
110RET0.40779718
111PLK40.40396955
112MST1R0.40093125
113CHEK20.39910421
114RPS6KA20.39751347
115DYRK1B0.39427251
116OBSCN0.38333787
117EGFR0.38071966
118GSK3A0.36907570
119KIT0.36768327
120GRK10.35079989
121STK380.34441326
122AURKA0.34172749
123ZAK0.33414568
124FGFR20.33395637
125BRSK20.33019002
126MAPK150.32920176
127MAPK10.32555829
128CHEK10.32334175
129TAOK20.32301248
130PDPK10.32203968
131TYK20.31832783
132CAMK40.29325899
133SRC0.27500078
134PAK10.26210330
135AKT20.26164962
136MAP3K10.26054051
137STK240.25889347
138FGFR30.25848352
139MAPK120.24794837

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.99210991
2Focal adhesion_Homo sapiens_hsa045102.48271761
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21198472
4Caffeine metabolism_Homo sapiens_hsa002322.10701401
5Fatty acid degradation_Homo sapiens_hsa000712.04053377
6Adherens junction_Homo sapiens_hsa045202.01045872
7Small cell lung cancer_Homo sapiens_hsa052221.85858984
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.85485408
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81523456
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74855559
11Protein digestion and absorption_Homo sapiens_hsa049741.72702956
12Proteoglycans in cancer_Homo sapiens_hsa052051.69030003
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.64814833
14Dilated cardiomyopathy_Homo sapiens_hsa054141.64558543
15Complement and coagulation cascades_Homo sapiens_hsa046101.62766322
16Hippo signaling pathway_Homo sapiens_hsa043901.57671978
17Amoebiasis_Homo sapiens_hsa051461.57405395
18PPAR signaling pathway_Homo sapiens_hsa033201.53538431
19Bladder cancer_Homo sapiens_hsa052191.53166073
20* TGF-beta signaling pathway_Homo sapiens_hsa043501.51725981
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49791002
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45581202
23Tryptophan metabolism_Homo sapiens_hsa003801.41497087
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39549157
25Tight junction_Homo sapiens_hsa045301.36849402
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.35829314
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31661407
28Other glycan degradation_Homo sapiens_hsa005111.31218265
29Thyroid cancer_Homo sapiens_hsa052161.28927367
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28230424
31Nitrogen metabolism_Homo sapiens_hsa009101.25121872
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24725023
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24227081
34Fat digestion and absorption_Homo sapiens_hsa049751.23286087
35Vitamin B6 metabolism_Homo sapiens_hsa007501.20555131
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19418930
37Basal cell carcinoma_Homo sapiens_hsa052171.19020993
38Propanoate metabolism_Homo sapiens_hsa006401.18782765
39Prion diseases_Homo sapiens_hsa050201.18641596
40Arginine biosynthesis_Homo sapiens_hsa002201.16725710
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16265194
42Chemical carcinogenesis_Homo sapiens_hsa052041.15079149
43Chronic myeloid leukemia_Homo sapiens_hsa052201.12328036
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10214481
45Notch signaling pathway_Homo sapiens_hsa043301.07283660
46Fatty acid metabolism_Homo sapiens_hsa012121.06909514
47Fructose and mannose metabolism_Homo sapiens_hsa000511.05128161
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04144989
49Selenocompound metabolism_Homo sapiens_hsa004501.02691981
50MicroRNAs in cancer_Homo sapiens_hsa052061.02616496
51Bile secretion_Homo sapiens_hsa049761.02597722
52Insulin resistance_Homo sapiens_hsa049311.00853713
53PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00319635
54Adipocytokine signaling pathway_Homo sapiens_hsa049201.00100796
55Malaria_Homo sapiens_hsa051440.99775560
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95948740
57Renin-angiotensin system_Homo sapiens_hsa046140.95876786
58Starch and sucrose metabolism_Homo sapiens_hsa005000.94756791
59Lysine degradation_Homo sapiens_hsa003100.93423316
60Cell cycle_Homo sapiens_hsa041100.92069088
61Systemic lupus erythematosus_Homo sapiens_hsa053220.91533315
62Carbon metabolism_Homo sapiens_hsa012000.91401073
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89834462
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89600511
65Platelet activation_Homo sapiens_hsa046110.87933985
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87335529
67Wnt signaling pathway_Homo sapiens_hsa043100.87218289
68HIF-1 signaling pathway_Homo sapiens_hsa040660.85360939
69Pentose phosphate pathway_Homo sapiens_hsa000300.84767753
70Melanogenesis_Homo sapiens_hsa049160.84756435
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84013151
72Toxoplasmosis_Homo sapiens_hsa051450.83202379
73Rap1 signaling pathway_Homo sapiens_hsa040150.83106271
74mTOR signaling pathway_Homo sapiens_hsa041500.83004088
75Viral myocarditis_Homo sapiens_hsa054160.82789472
76Pathways in cancer_Homo sapiens_hsa052000.82172864
77Endometrial cancer_Homo sapiens_hsa052130.81632432
78Insulin signaling pathway_Homo sapiens_hsa049100.80793428
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.80721621
80Glioma_Homo sapiens_hsa052140.80143922
81Axon guidance_Homo sapiens_hsa043600.76471879
82Phenylalanine metabolism_Homo sapiens_hsa003600.73014847
83Alcoholism_Homo sapiens_hsa050340.72265957
84Pyruvate metabolism_Homo sapiens_hsa006200.71709814
85Pancreatic cancer_Homo sapiens_hsa052120.71056548
86Retinol metabolism_Homo sapiens_hsa008300.69895947
87Staphylococcus aureus infection_Homo sapiens_hsa051500.68621913
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.68278838
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68237850
90Sulfur relay system_Homo sapiens_hsa041220.68225169
91Colorectal cancer_Homo sapiens_hsa052100.68096196
92Gap junction_Homo sapiens_hsa045400.66909396
93Glutathione metabolism_Homo sapiens_hsa004800.66811186
94Melanoma_Homo sapiens_hsa052180.66772070
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66572613
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65906496
97TNF signaling pathway_Homo sapiens_hsa046680.63120023
98Ovarian steroidogenesis_Homo sapiens_hsa049130.62857689
99Renal cell carcinoma_Homo sapiens_hsa052110.62680169
100Non-small cell lung cancer_Homo sapiens_hsa052230.62426159
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61456329
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61069828
103VEGF signaling pathway_Homo sapiens_hsa043700.60309907
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.60014389
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59599423
106HTLV-I infection_Homo sapiens_hsa051660.59329656
107DNA replication_Homo sapiens_hsa030300.59119626
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58827274
109N-Glycan biosynthesis_Homo sapiens_hsa005100.58777894
110FoxO signaling pathway_Homo sapiens_hsa040680.58127887
111Peroxisome_Homo sapiens_hsa041460.56642193
112Leishmaniasis_Homo sapiens_hsa051400.56067604
113Hedgehog signaling pathway_Homo sapiens_hsa043400.55281945
114Pertussis_Homo sapiens_hsa051330.55010861
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53621903
116Glucagon signaling pathway_Homo sapiens_hsa049220.52961329
117Shigellosis_Homo sapiens_hsa051310.51969119
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51947902
119Prostate cancer_Homo sapiens_hsa052150.50695429
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50526725
121ErbB signaling pathway_Homo sapiens_hsa040120.50462511
122Viral carcinogenesis_Homo sapiens_hsa052030.49900597
123Sulfur metabolism_Homo sapiens_hsa009200.49176959
124Apoptosis_Homo sapiens_hsa042100.49121651
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49016313
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48098322
127AMPK signaling pathway_Homo sapiens_hsa041520.47486638
128Thyroid hormone synthesis_Homo sapiens_hsa049180.46614858
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.45628832
130Biosynthesis of amino acids_Homo sapiens_hsa012300.45616591
131Acute myeloid leukemia_Homo sapiens_hsa052210.45409617
132Salmonella infection_Homo sapiens_hsa051320.44949229
133Lysosome_Homo sapiens_hsa041420.44042909
134Estrogen signaling pathway_Homo sapiens_hsa049150.44029662
135Choline metabolism in cancer_Homo sapiens_hsa052310.43943904
136Galactose metabolism_Homo sapiens_hsa000520.43622663
137mRNA surveillance pathway_Homo sapiens_hsa030150.42944199
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.42498295
139Arginine and proline metabolism_Homo sapiens_hsa003300.42087835
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42028136
141GnRH signaling pathway_Homo sapiens_hsa049120.40275272
142beta-Alanine metabolism_Homo sapiens_hsa004100.39711994
143Inositol phosphate metabolism_Homo sapiens_hsa005620.39019876
144Histidine metabolism_Homo sapiens_hsa003400.38121856

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