SMAD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ensheathment of neurons (GO:0007272)7.26635524
2axon ensheathment (GO:0008366)7.26635524
3myelination (GO:0042552)7.14283233
4fatty acid elongation (GO:0030497)5.94738353
5negative regulation of neurotransmitter secretion (GO:0046929)5.10736056
6myelin maintenance (GO:0043217)5.08321925
7regulation of vitamin D biosynthetic process (GO:0060556)4.91932588
8long-chain fatty acid biosynthetic process (GO:0042759)4.41737718
9adhesion of symbiont to host cell (GO:0044650)4.31407068
10virion attachment to host cell (GO:0019062)4.31407068
11astrocyte development (GO:0014002)4.30908665
12asymmetric protein localization (GO:0008105)4.26554412
13protein localization to endosome (GO:0036010)4.19140072
14regulation of vitamin metabolic process (GO:0030656)4.13780793
15negative regulation of neurotransmitter transport (GO:0051589)4.01271237
16creatine metabolic process (GO:0006600)3.96199269
17apical protein localization (GO:0045176)3.91026756
18cholesterol biosynthetic process (GO:0006695)3.89541287
19regulation of collateral sprouting (GO:0048670)3.88855982
20negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.83188318
21establishment of mitochondrion localization (GO:0051654)3.81029011
22positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.78971639
23negative regulation of interleukin-12 production (GO:0032695)3.78597443
24myelination in peripheral nervous system (GO:0022011)3.78312878
25peripheral nervous system axon ensheathment (GO:0032292)3.78312878
26oligodendrocyte differentiation (GO:0048709)3.76898363
27regulation of mononuclear cell migration (GO:0071675)3.61582393
28glycerophospholipid catabolic process (GO:0046475)3.60621904
29regulation of membrane protein ectodomain proteolysis (GO:0051043)3.56706099
30peptidyl-tyrosine autophosphorylation (GO:0038083)3.55094136
31positive regulation of chemokine biosynthetic process (GO:0045080)3.54352035
32NIK/NF-kappaB signaling (GO:0038061)3.49525389
33sterol biosynthetic process (GO:0016126)3.47498983
34response to peptidoglycan (GO:0032494)3.44547272
35Rap protein signal transduction (GO:0032486)3.42631087
36regulation of T-helper 1 cell differentiation (GO:0045625)3.37476746
37regulation of chronic inflammatory response (GO:0002676)3.36609127
38eye photoreceptor cell differentiation (GO:0001754)3.35190605
39photoreceptor cell differentiation (GO:0046530)3.35190605
40regulation of cytokine secretion involved in immune response (GO:0002739)3.32161393
41membrane tubulation (GO:0097320)3.31654821
42lipopolysaccharide-mediated signaling pathway (GO:0031663)3.29174911
43amyloid precursor protein metabolic process (GO:0042982)3.29132604
44regulation of chemokine biosynthetic process (GO:0045073)3.25015929
45membrane raft organization (GO:0031579)3.23219016
46import into cell (GO:0098657)3.21297386
47negative regulation of protein localization to cell surface (GO:2000009)3.19579533
48response to muramyl dipeptide (GO:0032495)3.18903509
49regulation of podosome assembly (GO:0071801)3.17252867
50interleukin-6-mediated signaling pathway (GO:0070102)3.16603337
51platelet-derived growth factor receptor signaling pathway (GO:0048008)3.15666624
52adhesion of symbiont to host (GO:0044406)3.15125107
53Leydig cell differentiation (GO:0033327)3.13099652
54cellular response to hepatocyte growth factor stimulus (GO:0035729)3.11231027
55response to hepatocyte growth factor (GO:0035728)3.11231027
56mesodermal cell differentiation (GO:0048333)3.09992586
57lateral sprouting from an epithelium (GO:0060601)3.06601221
58regulation of interleukin-13 production (GO:0032656)3.06190446
59positive regulation of p38MAPK cascade (GO:1900745)3.05845477
60myeloid dendritic cell differentiation (GO:0043011)3.03938837
61activation of MAPKKK activity (GO:0000185)3.03541949
62axon development (GO:0061564)3.02540318
63positive regulation of gliogenesis (GO:0014015)3.00872568
64positive regulation of glial cell differentiation (GO:0045687)3.00674336
65* response to laminar fluid shear stress (GO:0034616)2.97970700
66response to lipoprotein particle (GO:0055094)2.96125005
67response to redox state (GO:0051775)2.95237638
68macrophage activation involved in immune response (GO:0002281)2.95089243
69positive regulation of oligodendrocyte differentiation (GO:0048714)2.92238523
70negative regulation of cytokine production involved in immune response (GO:0002719)2.91108877
71isoprenoid biosynthetic process (GO:0008299)2.90742534
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90265680
73L-amino acid import (GO:0043092)2.89039062
74ear development (GO:0043583)2.88438871
75positive regulation by symbiont of host defense response (GO:0052509)2.87603764
76modulation by symbiont of host defense response (GO:0052031)2.87603764
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87603764
78modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87603764
79positive regulation by organism of defense response of other organism involved in symbiotic interact2.87603764
80modulation by symbiont of host immune response (GO:0052553)2.87603764
81branching involved in labyrinthine layer morphogenesis (GO:0060670)2.86951600
82oligosaccharide catabolic process (GO:0009313)2.86909455
83cranial suture morphogenesis (GO:0060363)2.82908089
84negative regulation of myoblast differentiation (GO:0045662)2.82807234
85limb bud formation (GO:0060174)2.82312585
86protein palmitoylation (GO:0018345)2.80990050
87type I interferon signaling pathway (GO:0060337)2.80484340
88cellular response to type I interferon (GO:0071357)2.80484340
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80366962
90positive regulation of heat generation (GO:0031652)2.78942740
91branching involved in mammary gland duct morphogenesis (GO:0060444)2.78075057
92response to type I interferon (GO:0034340)2.77546568
93embryonic process involved in female pregnancy (GO:0060136)2.77060822
94peripheral nervous system development (GO:0007422)2.76325995
95glycosphingolipid catabolic process (GO:0046479)2.74499372
96regulation of fever generation (GO:0031620)2.74443434
97positive regulation of extracellular matrix organization (GO:1903055)2.74397449
98response to methylmercury (GO:0051597)2.73577758
99T-helper 1 type immune response (GO:0042088)2.73387298
100positive regulation of actin filament depolymerization (GO:0030836)2.73123303
101regulation of myelination (GO:0031641)2.72862466
102cerebral cortex radially oriented cell migration (GO:0021799)2.72122804
103organ growth (GO:0035265)2.67518156
104regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.66707873
105regulation of lipoprotein metabolic process (GO:0050746)2.66682937
106regulation of T-helper 2 cell differentiation (GO:0045628)2.65604234
107negative regulation of nitric oxide biosynthetic process (GO:0045019)2.65182157
108negative regulation of erythrocyte differentiation (GO:0045647)2.65103018
109germinal center formation (GO:0002467)2.64948693
110cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.64832576
111positive regulation of osteoblast proliferation (GO:0033690)2.62611861
112decidualization (GO:0046697)2.62482933
113stress fiber assembly (GO:0043149)2.61579337
114cortical actin cytoskeleton organization (GO:0030866)2.60602380
115extracellular matrix assembly (GO:0085029)2.60590526
116membrane protein ectodomain proteolysis (GO:0006509)2.59747749
117regulation of type I interferon-mediated signaling pathway (GO:0060338)2.59323235
118negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58878748
119tolerance induction (GO:0002507)2.56013681
120mannose metabolic process (GO:0006013)2.55151946
121positive regulation by host of viral transcription (GO:0043923)2.53937767
122negative regulation of axonogenesis (GO:0050771)2.53287029
123positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52876633
124substantia nigra development (GO:0021762)2.52660985
125monocyte chemotaxis (GO:0002548)2.52237794
126regulation of interferon-alpha production (GO:0032647)2.51772818
127negative regulation of execution phase of apoptosis (GO:1900118)2.51543636
128retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49647458
129pinocytosis (GO:0006907)2.49105338
130regulation of p38MAPK cascade (GO:1900744)2.48718966
131myeloid dendritic cell activation (GO:0001773)2.48365277
132leukocyte migration involved in inflammatory response (GO:0002523)2.47704690
133nerve growth factor signaling pathway (GO:0038180)2.47282381
134glomerular filtration (GO:0003094)2.46215233
135regulation of macrophage chemotaxis (GO:0010758)2.45959506
136negative regulation of viral release from host cell (GO:1902187)2.45845204
137glycolipid catabolic process (GO:0019377)2.45814693
138phosphatidylinositol 3-kinase signaling (GO:0014065)2.45476742
139regulation of heterotypic cell-cell adhesion (GO:0034114)2.45365835
140low-density lipoprotein particle clearance (GO:0034383)2.44260782
141positive regulation of pseudopodium assembly (GO:0031274)2.44124664
142negative regulation of cell killing (GO:0031342)2.44101444
143negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44101444
144long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.43048691
145positive regulation of Rho protein signal transduction (GO:0035025)2.42241068
146positive regulation of endothelial cell apoptotic process (GO:2000353)2.41758924
147barbed-end actin filament capping (GO:0051016)2.41691673
148cell fate commitment involved in formation of primary germ layer (GO:0060795)2.41499656
149cellular response to thyroid hormone stimulus (GO:0097067)2.40740084
150cellular response to lipopolysaccharide (GO:0071222)2.40710354
151labyrinthine layer development (GO:0060711)2.40499667
152regulation of somitogenesis (GO:0014807)2.39850188
153cortical cytoskeleton organization (GO:0030865)2.39531184
154T cell migration (GO:0072678)2.38820899
155SMAD protein signal transduction (GO:0060395)2.38458076
156enteric nervous system development (GO:0048484)2.37823100
157regulation of interferon-beta biosynthetic process (GO:0045357)2.37246212
158negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37193487
159glycosylceramide metabolic process (GO:0006677)2.36939543
160positive regulation of astrocyte differentiation (GO:0048711)2.36928647
161negative regulation of lipid storage (GO:0010888)2.36305377
162regulation of T cell tolerance induction (GO:0002664)2.35996447
163positive regulation of cholesterol efflux (GO:0010875)2.35980816
164skin morphogenesis (GO:0043589)2.35593504
165regulation of nitric oxide biosynthetic process (GO:0045428)2.34714412
166regulation of interleukin-12 biosynthetic process (GO:0045075)2.34465304
167* negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.34100759
168positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.33511832
169anterior/posterior axis specification, embryo (GO:0008595)2.33447396
170regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.33195658
171apoptotic process involved in morphogenesis (GO:0060561)2.32878626
172positive regulation of NF-kappaB import into nucleus (GO:0042346)2.32712360
173renal filtration (GO:0097205)2.31708385
174heme transport (GO:0015886)2.31001013
175cellular response to molecule of bacterial origin (GO:0071219)2.30849759
176nuclear envelope reassembly (GO:0031468)2.30263085
177mitotic nuclear envelope reassembly (GO:0007084)2.30263085
178response to progesterone (GO:0032570)2.29321893
179ovulation (GO:0030728)2.29106149
180positive regulation of gamma-delta T cell activation (GO:0046645)2.28968818
181interferon-gamma-mediated signaling pathway (GO:0060333)2.28814181
182regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.27524190
183positive regulation of nitric oxide biosynthetic process (GO:0045429)2.26722256
184negative regulation of production of molecular mediator of immune response (GO:0002701)2.26693979
185positive regulation of type 2 immune response (GO:0002830)2.25445539
186regulation of NFAT protein import into nucleus (GO:0051532)2.25404938
187regulation of interleukin-12 production (GO:0032655)2.25153063
188regulation of apoptotic process involved in morphogenesis (GO:1902337)2.23636692
189response to protozoan (GO:0001562)2.23510619
190dendritic cell differentiation (GO:0097028)2.22884693
191regulation of cholesterol storage (GO:0010885)2.22510946
192axon ensheathment in central nervous system (GO:0032291)10.5186045
193central nervous system myelination (GO:0022010)10.5186045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.37541191
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.37541191
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.37541191
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.84258288
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.59999711
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.25398175
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.20121009
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.00660839
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78314939
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.72419607
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.69466376
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63347445
13* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.56321454
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55434438
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48307744
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.43130947
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.40753290
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.39700970
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38107196
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.30506790
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28339156
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25532490
23* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse2.23799926
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20741104
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18841328
26* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.16750363
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13267614
28* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.11821351
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.08356522
30* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.00501094
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98796848
32* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98349107
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.96649999
34* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95277970
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.94573088
36NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91312745
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.90805157
38* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88602267
39STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87109044
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86734180
41CLOCK_20551151_ChIP-Seq_293T_Human1.82610751
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82249452
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.81437350
44VDR_21846776_ChIP-Seq_THP-1_Human1.77792363
45* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.77510050
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77484472
47* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76047985
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71138795
49VDR_24763502_ChIP-Seq_THP-1_Human1.69982277
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59958830
51* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.57810855
52VDR_24787735_ChIP-Seq_THP-1_Human1.56838921
53* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55712870
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53528698
55* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52302380
56* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51479381
57VDR_22108803_ChIP-Seq_LS180_Human1.50657550
58* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.49292541
59* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45183872
60* MAF_26560356_Chip-Seq_TH1_Human1.42917761
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42793398
62LXR_22292898_ChIP-Seq_THP-1_Human1.42397380
63RUNX_20019798_ChIP-Seq_JUKART_Human1.38351114
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38064738
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37069441
66* MYC_22102868_ChIP-Seq_BL_Human1.36510228
67* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.34676794
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33301154
69TP53_16413492_ChIP-PET_HCT116_Human1.32219278
70* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29874241
71* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29618949
72* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.29462567
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29166921
74* RING1B_27294783_Chip-Seq_NPCs_Mouse1.28424602
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27051739
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26445071
77* RUNX1_22412390_ChIP-Seq_EML_Mouse1.25895288
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22904784
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22080088
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19875887
81* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19531343
82* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19357134
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19253149
84* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19065676
85* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18176272
86* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18176272
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18048891
88* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17992699
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.17205646
90PU_27001747_Chip-Seq_BMDM_Mouse1.17000521
91* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16505641
92* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15968619
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13528613
94* KDM2B_26808549_Chip-Seq_DND41_Human1.13375071
95IRF1_19129219_ChIP-ChIP_H3396_Human1.13330555
96* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12685565
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12107097
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11563040
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11339968
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11026034
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.09951143
102AR_21572438_ChIP-Seq_LNCaP_Human1.08881933
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.08317477
104* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08052934
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08031426
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.08027811
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06423402
108SPI1_23127762_ChIP-Seq_K562_Human1.05931265
109AHR_22903824_ChIP-Seq_MCF-7_Human1.05016889
110* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04999649
111CDX2_20551321_ChIP-Seq_CACO-2_Human1.04631020
112SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03948278
113UTX_26944678_Chip-Seq_JUKART_Human1.02828246
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00724283
115* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00416198
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.99943782
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.99943782
118* MYB_26560356_Chip-Seq_TH2_Human0.99521803
119* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98959066
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.98828912
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98648036
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96658075
123* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96278099
124RXR_22158963_ChIP-Seq_LIVER_Mouse0.96160709
125* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96118120
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95169488
127* MYB_26560356_Chip-Seq_TH1_Human0.94584010
128MAF_26560356_Chip-Seq_TH2_Human0.94390713
129* CJUN_26792858_Chip-Seq_BT549_Human0.94364263
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94316335
131* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93866141
132* KDM2B_26808549_Chip-Seq_K562_Human0.93679698
133* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93594935
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93400276
135* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93387692
136PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92988486
137* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92361804
138KLF5_25053715_ChIP-Seq_YYC3_Human0.91929313
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91845036
140* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91142727
141GATA1_19941826_ChIP-Seq_K562_Human0.90257335
142EOMES_21245162_ChIP-Seq_HESCs_Human0.89487342
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89105365
144BP1_19119308_ChIP-ChIP_Hs578T_Human0.88912805
145* RACK7_27058665_Chip-Seq_MCF-7_Human0.88476637
146SMAD_19615063_ChIP-ChIP_OVARY_Human0.88059039
147SOX2_16153702_ChIP-ChIP_HESCs_Human0.86573289
148* KDM2B_26808549_Chip-Seq_JURKAT_Human0.86368835
149* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.85929845
150E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85888708
151* ISL1_27105846_Chip-Seq_CPCs_Mouse0.85823091
152* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85651671
153SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85238351
154* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83969399
155TP53_22127205_ChIP-Seq_IMR90_Human0.82822165
156* EP300_21415370_ChIP-Seq_HL-1_Mouse0.82684735
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82429659
158NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82429659
159* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82119238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.09731721
2MP0003950_abnormal_plasma_membrane4.48089580
3MP0003303_peritoneal_inflammation4.26273751
4MP0009840_abnormal_foam_cell3.34717922
5MP0003436_decreased_susceptibility_to3.11955662
6MP0003300_gastrointestinal_ulcer3.11743035
7MP0004510_myositis3.11177349
8MP0003136_yellow_coat_color3.04417538
9MP0005058_abnormal_lysosome_morphology2.81057761
10MP0005171_absent_coat_pigmentation2.77239482
11MP0005623_abnormal_meninges_morphology2.74362845
12MP0000462_abnormal_digestive_system2.70701364
13MP0008438_abnormal_cutaneous_collagen2.65605460
14MP0003690_abnormal_glial_cell2.60567149
15MP0002254_reproductive_system_inflammat2.46484508
16MP0010678_abnormal_skin_adnexa2.43788355
17MP0003724_increased_susceptibility_to2.42284532
18MP0008057_abnormal_DNA_replication2.40445283
19MP0003705_abnormal_hypodermis_morpholog2.38626539
20MP0002148_abnormal_hypersensitivity_rea2.26245356
21MP0000383_abnormal_hair_follicle2.17930062
22MP0005000_abnormal_immune_tolerance2.12946928
23MP0009785_altered_susceptibility_to2.11579766
24MP0001533_abnormal_skeleton_physiology2.02408239
25MP0004947_skin_inflammation1.98044867
26MP0002998_abnormal_bone_remodeling1.97072697
27MP0001790_abnormal_immune_system1.95687877
28MP0005387_immune_system_phenotype1.95687877
29MP0002419_abnormal_innate_immunity1.91712436
30MP0004134_abnormal_chest_morphology1.89172409
31MP0003937_abnormal_limbs/digits/tail_de1.88288935
32MP0004742_abnormal_vestibular_system1.86140098
33MP0004272_abnormal_basement_membrane1.80033247
34MP0003191_abnormal_cellular_cholesterol1.79527227
35MP0000762_abnormal_tongue_morphology1.78943208
36MP0004885_abnormal_endolymph1.77741534
37MP0003634_abnormal_glial_cell1.76530936
38MP0003075_altered_response_to1.74634902
39MP0000343_altered_response_to1.70990522
40MP0008004_abnormal_stomach_pH1.69310767
41MP0005025_abnormal_response_to1.68596764
42MP0003453_abnormal_keratinocyte_physiol1.67587769
43MP0003448_altered_tumor_morphology1.67491721
44MP0001853_heart_inflammation1.66851734
45MP0005409_darkened_coat_color1.65614722
46MP0001851_eye_inflammation1.64835086
47MP0005671_abnormal_response_to1.64227118
48MP0001835_abnormal_antigen_presentation1.63666524
49MP0001485_abnormal_pinna_reflex1.63203210
50MP0001348_abnormal_lacrimal_gland1.60133861
51MP0003091_abnormal_cell_migration1.57435340
52MP0009764_decreased_sensitivity_to1.56746893
53* MP0002452_abnormal_antigen_presenting1.54494220
54MP0010352_gastrointestinal_tract_polyps1.53467759
55MP0010155_abnormal_intestine_physiology1.52346353
56MP0005076_abnormal_cell_differentiation1.51946495
57MP0002139_abnormal_hepatobiliary_system1.51302038
58MP0002723_abnormal_immune_serum1.51120126
59MP0000685_abnormal_immune_system1.49329974
60MP0002405_respiratory_system_inflammati1.48680094
61MP0005508_abnormal_skeleton_morphology1.48086908
62MP0005257_abnormal_intraocular_pressure1.46355959
63MP0006054_spinal_hemorrhage1.46154741
64MP0004185_abnormal_adipocyte_glucose1.46092804
65MP0001800_abnormal_humoral_immune1.45895144
66MP0009250_abnormal_appendicular_skeleto1.45178999
67MP0000467_abnormal_esophagus_morphology1.43654712
68MP0002295_abnormal_pulmonary_circulatio1.41932230
69MP0004133_heterotaxia1.41754589
70MP0005451_abnormal_body_composition1.40200531
71MP0002933_joint_inflammation1.39575811
72MP0000604_amyloidosis1.39218193
73MP0001845_abnormal_inflammatory_respons1.38340694
74MP0009333_abnormal_splenocyte_physiolog1.37941522
75MP0000858_altered_metastatic_potential1.34078718
76MP0000537_abnormal_urethra_morphology1.33544544
77MP0005310_abnormal_salivary_gland1.32464923
78MP0003172_abnormal_lysosome_physiology1.30239453
79MP0003763_abnormal_thymus_physiology1.29675342
80MP0005023_abnormal_wound_healing1.29437193
81MP0003755_abnormal_palate_morphology1.28134805
82MP0003566_abnormal_cell_adhesion1.27819312
83MP0001340_abnormal_eyelid_morphology1.25516876
84MP0000733_abnormal_muscle_development1.25406121
85MP0005390_skeleton_phenotype1.25083436
86* MP0001819_abnormal_immune_cell1.22597674
87* MP0002420_abnormal_adaptive_immunity1.22122974
88MP0000778_abnormal_nervous_system1.21401389
89MP0003632_abnormal_nervous_system1.21323446
90MP0006082_CNS_inflammation1.20735266
91MP0005166_decreased_susceptibility_to1.20304258
92MP0004142_abnormal_muscle_tone1.18602933
93MP0004381_abnormal_hair_follicle1.15980093
94MP0003385_abnormal_body_wall1.15286563
95MP0005367_renal/urinary_system_phenotyp1.13719655
96MP0000516_abnormal_urinary_system1.13719655
97MP0003045_fibrosis1.13151446
98MP0003279_aneurysm1.12307577
99MP0001243_abnormal_dermal_layer1.11613501
100MP0000566_synostosis1.11407107
101MP0008469_abnormal_protein_level1.10760273
102MP0005503_abnormal_tendon_morphology1.10715362
103MP0003828_pulmonary_edema1.09678001
104MP0001727_abnormal_embryo_implantation1.06585416
105MP0009384_cardiac_valve_regurgitation1.06407973
106MP0000432_abnormal_head_morphology1.06398352
107MP0001293_anophthalmia1.04518196
108MP0002332_abnormal_exercise_endurance1.03508027
109MP0003329_amyloid_beta_deposits1.02445458
110MP0005164_abnormal_response_to1.01904172
111MP0002138_abnormal_hepatobiliary_system1.01392333
112MP0000647_abnormal_sebaceous_gland1.00201605
113MP0010030_abnormal_orbit_morphology1.00023445
114MP0002092_abnormal_eye_morphology0.99352023
115MP0001905_abnormal_dopamine_level0.98307044
116* MP0002925_abnormal_cardiovascular_devel0.97326393
117MP0001958_emphysema0.97164780
118MP0003938_abnormal_ear_development0.96434802
119MP0000470_abnormal_stomach_morphology0.96083052
120MP0005165_increased_susceptibility_to0.95934498
121MP0005397_hematopoietic_system_phenotyp0.95842866
122MP0001545_abnormal_hematopoietic_system0.95842866
123MP0004270_analgesia0.95431095
124MP0009278_abnormal_bone_marrow0.94927473
125MP0002108_abnormal_muscle_morphology0.94281304
126MP0000465_gastrointestinal_hemorrhage0.93715861
127MP0001346_abnormal_lacrimal_gland0.93544409
128MP0001849_ear_inflammation0.93373536
129MP0003795_abnormal_bone_structure0.92480651
130MP0000249_abnormal_blood_vessel0.92279425
131MP0002133_abnormal_respiratory_system0.91384375
132MP0005388_respiratory_system_phenotype0.91384375
133MP0002111_abnormal_tail_morphology0.91318970
134MP0009053_abnormal_anal_canal0.89734495
135MP0002085_abnormal_embryonic_tissue0.88207804
136* MP0000716_abnormal_immune_system0.88062113
137MP0002249_abnormal_larynx_morphology0.87842761
138MP0005410_abnormal_fertilization0.87576468
139MP0003880_abnormal_central_pattern0.87395255
140MP0001614_abnormal_blood_vessel0.85053727
141MP0002932_abnormal_joint_morphology0.84551343
142MP0001873_stomach_inflammation0.84355709
143MP0002009_preneoplasia0.84297929
144MP0002896_abnormal_bone_mineralization0.84123032
145MP0005666_abnormal_adipose_tissue0.82640320
146MP0005595_abnormal_vascular_smooth0.82519069
147MP0005330_cardiomyopathy0.81884543
148MP0004808_abnormal_hematopoietic_stem0.81163179
149MP0005167_abnormal_blood-brain_barrier0.81050147
150MP0000747_muscle_weakness0.80627284
151MP0003935_abnormal_craniofacial_develop0.80240600
152MP0002084_abnormal_developmental_patter0.80232789
153MP0002229_neurodegeneration0.79769933
154MP0005275_abnormal_skin_tensile0.79183817
155MP0001486_abnormal_startle_reflex0.78777320
156MP0001542_abnormal_bone_strength0.78443437
157MP0002877_abnormal_melanocyte_morpholog0.77286673
158MP0000377_abnormal_hair_follicle0.74367330
159MP0002114_abnormal_axial_skeleton0.74197273
160MP0002282_abnormal_trachea_morphology0.73093733
161MP0008260_abnormal_autophagy0.72613446
162MP0005375_adipose_tissue_phenotype0.72452653
163MP0005195_abnormal_posterior_eye0.72223215
164* MP0001784_abnormal_fluid_regulation0.71176382
165MP0000767_abnormal_smooth_muscle0.71163497
166MP0002796_impaired_skin_barrier0.70811145
167MP0002272_abnormal_nervous_system0.70090657
168MP0002116_abnormal_craniofacial_bone0.69528405
169MP0003861_abnormal_nervous_system0.69382435
170MP0001299_abnormal_eye_distance/0.68275866
171* MP0002398_abnormal_bone_marrow0.68026316
172MP0004883_abnormal_blood_vessel0.65927460
173MP0010368_abnormal_lymphatic_system0.65605316
174MP0009763_increased_sensitivity_to0.64595427

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.62425315
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.62425315
3Abnormality of liposaccharide metabolism (HP:0010968)4.91120814
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.91120814
5Abnormality of glycolipid metabolism (HP:0010969)4.91120814
6Sensory axonal neuropathy (HP:0003390)4.86100580
7Premature skin wrinkling (HP:0100678)4.17001649
8Neurofibrillary tangles (HP:0002185)4.08701822
9Parakeratosis (HP:0001036)3.92015124
10Abnormality of the corticospinal tract (HP:0002492)3.89780602
11Peripheral hypomyelination (HP:0007182)3.77289160
12Coronal craniosynostosis (HP:0004440)3.76999455
13Dysostosis multiplex (HP:0000943)3.68457712
14Eczematoid dermatitis (HP:0000976)3.66684264
15Vacuolated lymphocytes (HP:0001922)3.57567687
16Systemic lupus erythematosus (HP:0002725)3.56340251
17Onion bulb formation (HP:0003383)3.47182334
18Abnormality of macrophages (HP:0004311)3.42271271
19Nuclear cataract (HP:0100018)3.35601135
20Loss of speech (HP:0002371)3.32949387
21Esophageal atresia (HP:0002032)3.29562158
22Alacrima (HP:0000522)3.26057383
23Increased cerebral lipofuscin (HP:0011813)3.21947144
24Spondylolisthesis (HP:0003302)3.16121452
25Premature rupture of membranes (HP:0001788)3.12330879
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.10364232
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.01275956
28Abnormality of polysaccharide metabolism (HP:0011012)3.01275956
29Abnormality of glycosaminoglycan metabolism (HP:0004371)3.01275956
30Interstitial pulmonary disease (HP:0006530)3.00454671
31Ulnar bowing (HP:0003031)2.98146166
32Chin dimple (HP:0010751)2.96197570
33Orchitis (HP:0100796)2.94407909
34Protrusio acetabuli (HP:0003179)2.94037586
35Urinary glycosaminoglycan excretion (HP:0003541)2.93613152
36Mucopolysacchariduria (HP:0008155)2.93613152
37Cerebral hypomyelination (HP:0006808)2.93199920
38Cerebral inclusion bodies (HP:0100314)2.91326474
39Stridor (HP:0010307)2.82849661
40Abnormality of the phalanges of the 2nd finger (HP:0009541)2.81967908
41Optic neuritis (HP:0100653)2.80419281
42Retrobulbar optic neuritis (HP:0100654)2.80419281
43Partial duplication of thumb phalanx (HP:0009944)2.72800624
44Fused cervical vertebrae (HP:0002949)2.72648951
45Anteriorly placed anus (HP:0001545)2.71628934
46Hematochezia (HP:0002573)2.71519243
47Disinhibition (HP:0000734)2.64762077
48Rectal fistula (HP:0100590)2.63150108
49Rectovaginal fistula (HP:0000143)2.63150108
50Partial duplication of the phalanx of hand (HP:0009999)2.60799146
51Thin bony cortex (HP:0002753)2.55226349
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.53965823
53Myositis (HP:0100614)2.53268292
54Rib fusion (HP:0000902)2.49328933
55Stenosis of the external auditory canal (HP:0000402)2.47737040
56Abnormal auditory evoked potentials (HP:0006958)2.46692951
57Vertebral compression fractures (HP:0002953)2.45847903
58Malnutrition (HP:0004395)2.43893702
59Hypoplastic ischia (HP:0003175)2.43648647
60Intestinal fistula (HP:0100819)2.43490556
61Recurrent bacterial skin infections (HP:0005406)2.43395101
62Recurrent abscess formation (HP:0002722)2.41930682
63Congenital ichthyosiform erythroderma (HP:0007431)2.41674469
64Autoamputation (HP:0001218)2.41388562
65Glomerulonephritis (HP:0000099)2.41349578
66Abnormality of the 2nd finger (HP:0004100)2.40670247
67Asplenia (HP:0001746)2.40522899
68Decreased lacrimation (HP:0000633)2.39184243
69Axonal loss (HP:0003447)2.38829676
70Gastrointestinal atresia (HP:0002589)2.35898779
71Adrenal hypoplasia (HP:0000835)2.35377117
72Hypoplasia of the iris (HP:0007676)2.35142991
73Stomatitis (HP:0010280)2.34359737
74Short humerus (HP:0005792)2.33867587
75Concave nail (HP:0001598)2.32840050
76Intention tremor (HP:0002080)2.32770162
77Vertebral clefting (HP:0008428)2.32061445
78Myocardial infarction (HP:0001658)2.28618689
79Muscle fiber splitting (HP:0003555)2.27052962
80Absent septum pellucidum (HP:0001331)2.26622009
81Round ear (HP:0100830)2.25290699
82Thickened helices (HP:0000391)2.24815659
83Aplasia/hypoplasia of the humerus (HP:0006507)2.24803571
84Clumsiness (HP:0002312)2.24502235
85Mediastinal lymphadenopathy (HP:0100721)2.24160110
86Short hallux (HP:0010109)2.23697455
87Aortic aneurysm (HP:0004942)2.23369975
88Relative macrocephaly (HP:0004482)2.22268482
89Cerebral aneurysm (HP:0004944)2.21687961
90Genu recurvatum (HP:0002816)2.21586615
91Hyporeflexia of lower limbs (HP:0002600)2.19560800
92Asymmetric septal hypertrophy (HP:0001670)2.16881503
93Aplasia/Hypoplasia of the spleen (HP:0010451)2.16733924
94Dysmetria (HP:0001310)2.15664036
95Autoimmune thrombocytopenia (HP:0001973)2.14827263
96Large earlobe (HP:0009748)2.13397545
97Abnormal vertebral ossification (HP:0100569)2.12359660
98Pulmonary infiltrates (HP:0002113)2.11685303
99Segmental peripheral demyelination/remyelination (HP:0003481)2.10944698
100Osteolytic defects of the phalanges of the hand (HP:0009771)2.10791353
101Osteolytic defects of the hand bones (HP:0009699)2.10791353
102Vaginal fistula (HP:0004320)2.10039579
103Anomalous pulmonary venous return (HP:0010772)2.07924624
104Hypoplastic pelvis (HP:0008839)2.07003471
105Abnormality of the middle phalanges of the toes (HP:0010183)2.06602585
106Aortic dissection (HP:0002647)2.06369619
107Abnormality of the ischium (HP:0003174)2.05588545
108Aplasia/Hypoplasia of the hallux (HP:0008362)2.03430563
109Dilatation of the ascending aorta (HP:0005111)2.02807340
110Spastic gait (HP:0002064)2.02349909
111Preaxial foot polydactyly (HP:0001841)2.01893520
112Absent radius (HP:0003974)2.01531820
113Persistence of primary teeth (HP:0006335)2.01341025
114Vascular tortuosity (HP:0004948)2.00566917
115Recurrent gram-negative bacterial infections (HP:0005420)2.00376438
116Mutism (HP:0002300)1.99785066
117Cervical subluxation (HP:0003308)1.97204960
118Slow saccadic eye movements (HP:0000514)1.97197478
119Septo-optic dysplasia (HP:0100842)1.96466508
120Abnormality of the septum pellucidum (HP:0007375)1.95403799
121Infantile muscular hypotonia (HP:0008947)1.95280442
122Scanning speech (HP:0002168)1.95219928
123Abnormality of the salivary glands (HP:0010286)1.94942240
124Sparse lateral eyebrow (HP:0005338)1.94531141
125Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.93668236
126Joint stiffness (HP:0001387)1.92911730
127Abnormality of the pulmonary veins (HP:0011718)1.92537009
128Prominent occiput (HP:0000269)1.92310148
129Disproportionate tall stature (HP:0001519)1.90494206
130Abnormality of the fetal cardiovascular system (HP:0010948)1.88702749
131Abnormal umbilical cord blood vessels (HP:0011403)1.88702749
132Single umbilical artery (HP:0001195)1.88702749
133Supernumerary ribs (HP:0005815)1.88677956
134Abnormality of the distal phalanx of the thumb (HP:0009617)1.88181435
135Small epiphyses (HP:0010585)1.88014576
136Absent forearm bone (HP:0003953)1.87988714
137Aplasia involving forearm bones (HP:0009822)1.87988714
138Insidious onset (HP:0003587)1.87573675
139Termporal pattern (HP:0011008)1.87573675
140Foot dorsiflexor weakness (HP:0009027)1.87170069
141Basal ganglia calcification (HP:0002135)1.87054365
142Apathy (HP:0000741)1.86918175
143Bone pain (HP:0002653)1.86391427
144Ileus (HP:0002595)1.85390577
145Aneurysm (HP:0002617)1.85222879
146Increased CSF protein (HP:0002922)1.83747712
147Epiphyseal dysplasia (HP:0002656)1.83702121
148Vertebral fusion (HP:0002948)1.83465651
149Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82943253
150Complement deficiency (HP:0004431)1.82515370
151Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82399871
152Emphysema (HP:0002097)1.82312516
153Mitral valve prolapse (HP:0001634)1.81479742
154Depressed nasal tip (HP:0000437)1.80662161
155Shallow orbits (HP:0000586)1.80588941
156Cupped ear (HP:0000378)1.79313600
157Arterial tortuosity (HP:0005116)1.79118253
158Scapular winging (HP:0003691)1.79081546
159Gingivitis (HP:0000230)1.79070581
160Keratoconjunctivitis sicca (HP:0001097)1.77565648
161Distal lower limb muscle weakness (HP:0009053)1.77479258
162Obstructive sleep apnea (HP:0002870)1.76833659
163Split foot (HP:0001839)1.76761846
164Tracheal stenosis (HP:0002777)1.76643151
165Thoracolumbar scoliosis (HP:0002944)1.76124217
166Barrel-shaped chest (HP:0001552)1.75887785
167Arnold-Chiari malformation (HP:0002308)1.74877907
168Mitral regurgitation (HP:0001653)1.74832029
169Blue sclerae (HP:0000592)1.74175652
170Abnormality of complement system (HP:0005339)1.74008959
171Abnormality of the lumbar spine (HP:0100712)1.73256531
172Neuronal loss in central nervous system (HP:0002529)1.73011427
173Syringomyelia (HP:0003396)1.72895242
174Spinal cord lesions (HP:0100561)1.72895242
175Broad metatarsal (HP:0001783)1.71381516
176Diminished motivation (HP:0000745)1.71046939
177Protuberant abdomen (HP:0001538)1.70684865
178Hyperparathyroidism (HP:0000843)1.70414770
179Atrophic scars (HP:0001075)1.70279690
180J-shaped sella turcica (HP:0002680)1.70275435
181Vasculitis (HP:0002633)1.69076667
182T lymphocytopenia (HP:0005403)1.67037562
183Hemoptysis (HP:0002105)1.66636833
184Esophageal varix (HP:0002040)1.66363984
185Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66200238
186Spontaneous hematomas (HP:0007420)1.66097998
187Increased IgM level (HP:0003496)1.66087340
188Peritonitis (HP:0002586)1.65962979
189Increased connective tissue (HP:0009025)1.62771627
190Amyloidosis (HP:0011034)1.61591475
191Distal lower limb amyotrophy (HP:0008944)1.61449357
192Pulmonary hypertension (HP:0002092)1.59150840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.70847629
2IRAK34.10697221
3EPHB13.83614877
4OXSR13.58705400
5RIPK13.07417945
6ICK2.92875784
7MAPK152.83029924
8MAP3K142.82702046
9MET2.54217274
10FGFR22.21382985
11CLK12.20079605
12BCR2.08679550
13PKN12.07851419
14TYRO32.06812708
15TAOK22.04251141
16FGR2.02670560
17WNK11.97939966
18WNK41.95720986
19TBK11.95589598
20CDC42BPA1.84793827
21MAP3K31.84101310
22DDR21.81589468
23EPHA21.78030580
24TRIB31.77918047
25IRAK41.76980167
26TYK21.70531510
27PRPF4B1.67238892
28BLK1.66052352
29NME21.65445224
30MAPKAPK51.63931965
31SIK11.62599891
32CDK121.62238632
33IKBKE1.55715639
34STK101.54361894
35ERN11.52577337
36PIM21.48319239
37TAOK11.45722029
38MAP3K131.41976374
39UHMK11.41237079
40MAP2K31.40683566
41STK241.40568665
42MST41.40283315
43CHUK1.37180420
44ZAP701.36586055
45NEK61.34689947
46TXK1.34278164
47ROCK21.29401398
48TGFBR21.27756214
49CSK1.26754883
50DMPK1.26631075
51PAK21.24512369
52CSNK1A1L1.20780576
53LIMK11.18763675
54FGFR41.18442961
55CDK191.18012102
56MAP2K21.15490192
57JAK11.13695524
58BRD41.12015816
59MATK1.10387928
60MAP3K11.09275742
61CSNK1G31.05388283
62IRAK11.05215945
63MARK21.04931085
64CSNK1G11.04757511
65ITK1.04122877
66PNCK1.03064698
67TRPM71.01871997
68PAK61.01827526
69SMG11.01278658
70GSK3A1.00744206
71JAK30.99234906
72BMX0.98365750
73PRKD20.97934377
74CAMK2B0.96970298
75IRAK20.95551842
76NEK90.95485894
77PBK0.95405114
78MAPK70.95238416
79PDGFRB0.91329252
80NTRK10.90942060
81MAP3K110.89534518
82CAMK2D0.89277829
83PAK40.88652362
84RPS6KA50.88332205
85PRKD10.87173479
86MKNK10.87129251
87TESK20.84481430
88PAK30.84147128
89RPS6KL10.82165266
90RPS6KC10.82165266
91CDK60.81196002
92ABL20.80508560
93TNIK0.80263536
94PTK20.76803236
95AKT30.76426847
96RPS6KA20.74546667
97SIK30.72239484
98RIPK40.71300602
99BMPR20.68581524
100CSF1R0.68220756
101FGFR30.67411905
102ACVR1B0.65475547
103HIPK20.63872607
104EPHA30.63709570
105ALK0.63648133
106INSR0.63408921
107PRKCQ0.62816839
108RPS6KA60.62608323
109CAMK1D0.61614908
110PIM10.61370049
111ERBB40.61169920
112HCK0.60019829
113MOS0.59821162
114MYLK0.58440975
115CSNK1G20.58250309
116MAP3K60.57311863
117EPHB20.55936821
118PDPK10.55581411
119DYRK20.55537904
120JAK20.54830219
121CSNK1D0.54435853
122MAP3K50.54353014
123LCK0.52565374
124MKNK20.52087224
125GRK10.51950030
126CDK40.51752862
127IKBKB0.50920662
128TIE10.50217846
129STK30.48213390
130CAMK2G0.47785226
131MAPK40.47511865
132ARAF0.47186157
133MAP3K100.45931777
134PIK3CA0.45891402
135PAK10.44898404
136MTOR0.44792720
137STK110.44308386
138GRK70.43688676
139EEF2K0.42384152
140PDK10.41726234
141KSR20.41662999
142LATS10.41124402
143SGK30.41009716
144LMTK20.40440616
145MAPK10.39682659
146CDK140.39555937
147TLK10.37791084
148FYN0.37532021
149CAMKK20.37277847
150DYRK1B0.36570711
151CDK70.36130734
152LYN0.36081473
153STK40.35948539
154ABL10.35669874
155PTK2B0.34423048
156PRKG20.34112352
157TTN0.34079959
158MAP4K10.33931328
159NLK0.33448531
160MAPKAPK20.33211657
161MAPK100.30727281
162PDGFRA0.30717362
163MAP3K80.30669713
164LATS20.29118951
165CDK150.28524085
166SGK2230.28168491

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.64670046
2Steroid biosynthesis_Homo sapiens_hsa001003.88557107
3Ether lipid metabolism_Homo sapiens_hsa005653.30868606
4Fatty acid elongation_Homo sapiens_hsa000623.07356960
5Other glycan degradation_Homo sapiens_hsa005112.76461397
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.35034630
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32230640
8TNF signaling pathway_Homo sapiens_hsa046682.22876650
9Axon guidance_Homo sapiens_hsa043602.22497901
10Renal cell carcinoma_Homo sapiens_hsa052112.13382788
11Leishmaniasis_Homo sapiens_hsa051401.98365721
12Tight junction_Homo sapiens_hsa045301.95281105
13Lysosome_Homo sapiens_hsa041421.88646399
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.88147324
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.87595103
16Pertussis_Homo sapiens_hsa051331.79990157
17ECM-receptor interaction_Homo sapiens_hsa045121.74303550
18Linoleic acid metabolism_Homo sapiens_hsa005911.72038480
19Staphylococcus aureus infection_Homo sapiens_hsa051501.70258897
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.69975005
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66314888
22Regulation of actin cytoskeleton_Homo sapiens_hsa048101.65659294
23Sphingolipid metabolism_Homo sapiens_hsa006001.64717525
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63504372
25Toxoplasmosis_Homo sapiens_hsa051451.59893588
26Allograft rejection_Homo sapiens_hsa053301.59614861
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.58430377
28Tuberculosis_Homo sapiens_hsa051521.52695252
29Legionellosis_Homo sapiens_hsa051341.52443245
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.49141401
31Hedgehog signaling pathway_Homo sapiens_hsa043401.43802278
32Influenza A_Homo sapiens_hsa051641.42206005
33Sulfur metabolism_Homo sapiens_hsa009201.42139465
34Graft-versus-host disease_Homo sapiens_hsa053321.41147215
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38770381
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35703082
37Arachidonic acid metabolism_Homo sapiens_hsa005901.30836310
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.30790712
39Focal adhesion_Homo sapiens_hsa045101.30730639
40Ras signaling pathway_Homo sapiens_hsa040141.29879219
41Bladder cancer_Homo sapiens_hsa052191.28698197
42* TGF-beta signaling pathway_Homo sapiens_hsa043501.28376594
43Hepatitis C_Homo sapiens_hsa051601.26800600
44* Hippo signaling pathway_Homo sapiens_hsa043901.26764456
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26649611
46Malaria_Homo sapiens_hsa051441.25787336
47Measles_Homo sapiens_hsa051621.25396437
48ErbB signaling pathway_Homo sapiens_hsa040121.22530185
49T cell receptor signaling pathway_Homo sapiens_hsa046601.22154059
50Hepatitis B_Homo sapiens_hsa051611.21954445
51Arginine and proline metabolism_Homo sapiens_hsa003301.18485477
52Dorso-ventral axis formation_Homo sapiens_hsa043201.18343440
53Sphingolipid signaling pathway_Homo sapiens_hsa040711.17208430
54Choline metabolism in cancer_Homo sapiens_hsa052311.16001370
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15316750
56Notch signaling pathway_Homo sapiens_hsa043301.15192788
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.13316865
58African trypanosomiasis_Homo sapiens_hsa051431.12771141
59PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11507398
60Basal cell carcinoma_Homo sapiens_hsa052171.11019396
61Endocytosis_Homo sapiens_hsa041441.09650363
62Asthma_Homo sapiens_hsa053101.09621556
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08962629
64Phospholipase D signaling pathway_Homo sapiens_hsa040721.08565158
65MicroRNAs in cancer_Homo sapiens_hsa052061.08515086
66Apoptosis_Homo sapiens_hsa042101.04245810
67Adherens junction_Homo sapiens_hsa045201.03425314
68Proteoglycans in cancer_Homo sapiens_hsa052051.02232460
69Wnt signaling pathway_Homo sapiens_hsa043101.00387316
70Herpes simplex infection_Homo sapiens_hsa051680.99275475
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97865635
72MAPK signaling pathway_Homo sapiens_hsa040100.97445446
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96280512
74Prolactin signaling pathway_Homo sapiens_hsa049170.95284224
75Rap1 signaling pathway_Homo sapiens_hsa040150.94270882
76Prostate cancer_Homo sapiens_hsa052150.92116877
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91877061
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91735764
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.91487514
80Type I diabetes mellitus_Homo sapiens_hsa049400.90465950
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88838512
82Antigen processing and presentation_Homo sapiens_hsa046120.87612574
83Shigellosis_Homo sapiens_hsa051310.86387351
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86062871
85Long-term depression_Homo sapiens_hsa047300.85107400
86Pathways in cancer_Homo sapiens_hsa052000.83927537
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83679538
88Autoimmune thyroid disease_Homo sapiens_hsa053200.83258054
89Vitamin B6 metabolism_Homo sapiens_hsa007500.83160881
90B cell receptor signaling pathway_Homo sapiens_hsa046620.82597636
91Phagosome_Homo sapiens_hsa041450.82038242
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.80996101
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79045532
94FoxO signaling pathway_Homo sapiens_hsa040680.77927449
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77037333
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76526380
97Mineral absorption_Homo sapiens_hsa049780.75943228
98HTLV-I infection_Homo sapiens_hsa051660.75393896
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74206721
100Complement and coagulation cascades_Homo sapiens_hsa046100.73230639
101Basal transcription factors_Homo sapiens_hsa030220.72673899
102Insulin resistance_Homo sapiens_hsa049310.71645820
103VEGF signaling pathway_Homo sapiens_hsa043700.71620580
104Type II diabetes mellitus_Homo sapiens_hsa049300.70451190
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.68406509
106Platelet activation_Homo sapiens_hsa046110.66394095
107GnRH signaling pathway_Homo sapiens_hsa049120.65651059
108Salmonella infection_Homo sapiens_hsa051320.65422873
109Small cell lung cancer_Homo sapiens_hsa052220.64748728
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64740589
111HIF-1 signaling pathway_Homo sapiens_hsa040660.62173363
112Protein digestion and absorption_Homo sapiens_hsa049740.61932199
113Ovarian steroidogenesis_Homo sapiens_hsa049130.60421805
114Endometrial cancer_Homo sapiens_hsa052130.58909570
115mTOR signaling pathway_Homo sapiens_hsa041500.57954869
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57318510
117Chemokine signaling pathway_Homo sapiens_hsa040620.56967792
118Histidine metabolism_Homo sapiens_hsa003400.56861231
119Primary immunodeficiency_Homo sapiens_hsa053400.55694955
120Glutathione metabolism_Homo sapiens_hsa004800.55692564
121Serotonergic synapse_Homo sapiens_hsa047260.55508180
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55456814
123Fatty acid biosynthesis_Homo sapiens_hsa000610.54762192
124Rheumatoid arthritis_Homo sapiens_hsa053230.54731714
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54484657
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53918490
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53330286
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52991653
129Epstein-Barr virus infection_Homo sapiens_hsa051690.51887260
130Prion diseases_Homo sapiens_hsa050200.49756908
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.49544951
132Non-small cell lung cancer_Homo sapiens_hsa052230.49056062
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48370351
134Amoebiasis_Homo sapiens_hsa051460.48365400
135Galactose metabolism_Homo sapiens_hsa000520.48329621
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.47465595
137Dilated cardiomyopathy_Homo sapiens_hsa054140.46864605
138Pancreatic cancer_Homo sapiens_hsa052120.45966787
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45002023
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42667390
141Hematopoietic cell lineage_Homo sapiens_hsa046400.41233437
142Osteoclast differentiation_Homo sapiens_hsa043800.40887853
143Viral carcinogenesis_Homo sapiens_hsa052030.40140083
144Chronic myeloid leukemia_Homo sapiens_hsa052200.38203573
145Viral myocarditis_Homo sapiens_hsa054160.37897821
146RNA polymerase_Homo sapiens_hsa030200.36043730
147Colorectal cancer_Homo sapiens_hsa052100.35179242
148Acute myeloid leukemia_Homo sapiens_hsa052210.35114579
149Inositol phosphate metabolism_Homo sapiens_hsa005620.33419003
150Protein export_Homo sapiens_hsa030600.32511036
151NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31724746

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