SMAD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)4.33927624
2gamma-aminobutyric acid transport (GO:0015812)4.29113566
3glutamate secretion (GO:0014047)4.12999513
4neurotransmitter secretion (GO:0007269)3.91217046
5regulation of short-term neuronal synaptic plasticity (GO:0048172)3.88306631
6neuromuscular process controlling posture (GO:0050884)3.71058358
7neurofilament cytoskeleton organization (GO:0060052)3.60228923
8synaptic vesicle exocytosis (GO:0016079)3.53062317
9synaptic vesicle maturation (GO:0016188)3.51160468
10negative regulation of dendrite morphogenesis (GO:0050774)3.46697394
11neurotransmitter transport (GO:0006836)3.44373222
12vocalization behavior (GO:0071625)3.43850116
13negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38334949
14neuron cell-cell adhesion (GO:0007158)3.34376214
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28890421
16response to pheromone (GO:0019236)3.28867817
17righting reflex (GO:0060013)3.24249449
18limb bud formation (GO:0060174)3.23456016
19regulation of neurotransmitter levels (GO:0001505)3.23156756
20indolalkylamine catabolic process (GO:0046218)3.19403508
21tryptophan catabolic process (GO:0006569)3.19403508
22indole-containing compound catabolic process (GO:0042436)3.19403508
23negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19033569
24regulation of hexokinase activity (GO:1903299)3.18974110
25regulation of glucokinase activity (GO:0033131)3.18974110
26omega-hydroxylase P450 pathway (GO:0097267)3.14236571
27aromatic amino acid family catabolic process (GO:0009074)3.11522993
28pyrimidine nucleobase catabolic process (GO:0006208)3.09388077
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.05153731
30tryptophan metabolic process (GO:0006568)3.04970265
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.03283273
32L-phenylalanine catabolic process (GO:0006559)3.03283273
33cerebellar Purkinje cell differentiation (GO:0021702)3.02968549
34auditory behavior (GO:0031223)3.00553088
35coenzyme catabolic process (GO:0009109)3.00272927
36indolalkylamine metabolic process (GO:0006586)2.98211484
37regulation of synaptic vesicle exocytosis (GO:2000300)2.97387244
38neurotransmitter catabolic process (GO:0042135)2.96375324
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.94606254
40regulation of action potential (GO:0098900)2.92402999
41NAD biosynthetic process (GO:0009435)2.91083120
42negative regulation of dendrite development (GO:2000171)2.90381570
43behavioral response to nicotine (GO:0035095)2.90274558
44regulation of vesicle fusion (GO:0031338)2.87693304
45protein localization to cilium (GO:0061512)2.87613124
46kidney morphogenesis (GO:0060993)2.87019628
47neuron-neuron synaptic transmission (GO:0007270)2.87017834
48proline transport (GO:0015824)2.86031464
49dopamine transport (GO:0015872)2.84182038
50regulation of neurotransmitter secretion (GO:0046928)2.83239823
51dendritic spine morphogenesis (GO:0060997)2.83055802
52regulation of synaptic vesicle transport (GO:1902803)2.82293318
53glycine transport (GO:0015816)2.80853863
54phenol-containing compound catabolic process (GO:0019336)2.80791134
55regulation of neurotransmitter transport (GO:0051588)2.80572206
56transmission of nerve impulse (GO:0019226)2.77979841
57locomotory exploration behavior (GO:0035641)2.77629982
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76714454
59synaptic transmission, glutamatergic (GO:0035249)2.75912195
60low-density lipoprotein particle remodeling (GO:0034374)2.72738648
61axonal fasciculation (GO:0007413)2.72587511
62postsynaptic membrane organization (GO:0001941)2.71797892
63neurotransmitter-gated ion channel clustering (GO:0072578)2.70057513
64spinal cord motor neuron differentiation (GO:0021522)2.69560462
65peripheral nervous system neuron development (GO:0048935)2.69322109
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68383992
67L-amino acid import (GO:0043092)2.68345671
68nucleobase catabolic process (GO:0046113)2.68039592
69neural tube formation (GO:0001841)2.66246650
70reflex (GO:0060004)2.65938353
71behavioral response to ethanol (GO:0048149)2.65426617
72cellular biogenic amine catabolic process (GO:0042402)2.65241856
73amine catabolic process (GO:0009310)2.65241856
74nonmotile primary cilium assembly (GO:0035058)2.65004207
75regulation of neuronal synaptic plasticity (GO:0048168)2.64628918
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.64103251
77L-phenylalanine metabolic process (GO:0006558)2.64103251
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62743460
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.61901833
80ionotropic glutamate receptor signaling pathway (GO:0035235)2.61648226
81positive regulation of glycolytic process (GO:0045821)2.60961948
82retinal ganglion cell axon guidance (GO:0031290)2.60707612
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60454376
84negative regulation of translation, ncRNA-mediated (GO:0040033)2.60454376
85regulation of translation, ncRNA-mediated (GO:0045974)2.60454376
86sympathetic nervous system development (GO:0048485)2.60277797
87aromatic amino acid family metabolic process (GO:0009072)2.59304035
88* hindbrain development (GO:0030902)2.58775006
89behavioral response to pain (GO:0048266)2.58684440
90regulation of synaptic transmission, GABAergic (GO:0032228)2.58414182
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58281643
92catecholamine transport (GO:0051937)2.56780160
93negative regulation of hormone biosynthetic process (GO:0032353)2.56576461
94behavioral response to cocaine (GO:0048148)2.55894859
95protein localization to synapse (GO:0035418)2.55510271
96tyrosine metabolic process (GO:0006570)2.55258005
97kynurenine metabolic process (GO:0070189)2.54968001
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.54894263
99enteric nervous system development (GO:0048484)2.53746469
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.53393013
101neuron recognition (GO:0008038)2.52254297
102detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51904665
103regulation of long-term neuronal synaptic plasticity (GO:0048169)2.51636921
104neuronal action potential (GO:0019228)2.51325209
105somite development (GO:0061053)2.50902198
106membrane depolarization during action potential (GO:0086010)2.50871855
107neurotransmitter uptake (GO:0001504)2.49786397
108regulation of respiratory system process (GO:0044065)2.49623915
109presynaptic membrane assembly (GO:0097105)2.48563128
110adult walking behavior (GO:0007628)2.48530665
111synaptic vesicle endocytosis (GO:0048488)2.48276471
112response to pain (GO:0048265)2.47933482
113limb development (GO:0060173)2.47546863
114appendage development (GO:0048736)2.47546863
115relaxation of cardiac muscle (GO:0055119)2.46880752
116mechanosensory behavior (GO:0007638)2.46857091
117synapse assembly (GO:0007416)2.45614085
118cofactor catabolic process (GO:0051187)2.45554363
119calcium ion-dependent exocytosis (GO:0017156)2.45377130
120protein heterotetramerization (GO:0051290)2.44882695
121mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44660974
122startle response (GO:0001964)2.44420276
123glutamate receptor signaling pathway (GO:0007215)2.43958019
124somite rostral/caudal axis specification (GO:0032525)2.43315623
125regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42857543
126neurotransmitter metabolic process (GO:0042133)2.42689275
127response to auditory stimulus (GO:0010996)2.42420814
128vascular smooth muscle contraction (GO:0014829)2.41277188
129regulation of respiratory gaseous exchange (GO:0043576)2.41106708
130alkaloid metabolic process (GO:0009820)2.41097466
131neuromuscular synaptic transmission (GO:0007274)2.40086264
132otic vesicle formation (GO:0030916)2.39251022
133cell migration in hindbrain (GO:0021535)2.38064912
134central nervous system neuron axonogenesis (GO:0021955)2.38059334
135presynaptic membrane organization (GO:0097090)2.37998412
136bile acid biosynthetic process (GO:0006699)2.37710787
137atrial cardiac muscle cell action potential (GO:0086014)2.37248494
138endocardial cushion morphogenesis (GO:0003203)2.36890125
139glucuronate metabolic process (GO:0019585)2.36765180
140uronic acid metabolic process (GO:0006063)2.36765180
141glutamate metabolic process (GO:0006536)2.36650883
142regulation of cell communication by electrical coupling (GO:0010649)2.35434612
143intraciliary transport (GO:0042073)2.32491966
144positive regulation of oligodendrocyte differentiation (GO:0048714)2.30631858
145nephron epithelium morphogenesis (GO:0072088)2.29690848
146nephron tubule morphogenesis (GO:0072078)2.29690848
147cilium morphogenesis (GO:0060271)2.28740577
148neuron fate determination (GO:0048664)2.28422238
149endocrine pancreas development (GO:0031018)2.28395252
150positive regulation of glycogen biosynthetic process (GO:0045725)2.28214030
151mesenchyme morphogenesis (GO:0072132)2.27185281
152synaptic transmission, cholinergic (GO:0007271)2.26829220
153regulation of neurotransmitter uptake (GO:0051580)2.23354533
154central nervous system projection neuron axonogenesis (GO:0021952)2.23279692
155regulation of axon guidance (GO:1902667)2.22781253
156positive regulation of meiosis (GO:0045836)2.21842931
157negative regulation of sodium ion transport (GO:0010766)2.21341979
158cellular ketone body metabolic process (GO:0046950)2.19621976
159calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.18760140
160cilium organization (GO:0044782)2.18606659
161embryonic epithelial tube formation (GO:0001838)2.18399071
162cilium assembly (GO:0042384)2.18354167
163negative regulation of axon guidance (GO:1902668)2.18058777
164dopaminergic neuron differentiation (GO:0071542)2.17617275
165keratinocyte development (GO:0003334)2.17176524
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.17095521
167renal tubule morphogenesis (GO:0061333)2.16715768
168multicellular organismal signaling (GO:0035637)2.14886451
169spinal cord development (GO:0021510)2.14825332
170inositol phosphate catabolic process (GO:0071545)2.14208723
171positive regulation of gastrulation (GO:2000543)2.12559038
172smoothened signaling pathway (GO:0007224)2.12544873
173regulation of relaxation of muscle (GO:1901077)2.12014040
174regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.10681082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.03923269
2GBX2_23144817_ChIP-Seq_PC3_Human3.89732945
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74753980
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70000688
5ZNF274_21170338_ChIP-Seq_K562_Hela2.61213742
6TAF15_26573619_Chip-Seq_HEK293_Human2.55693418
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51748619
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.47524658
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44246399
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37446993
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36342823
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35328696
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35111533
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35111533
15FUS_26573619_Chip-Seq_HEK293_Human2.23675532
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19982233
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.17135946
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15519306
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12347625
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09200823
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05159869
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05061879
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.04512996
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04373263
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94638234
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93741054
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92113590
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.91565488
29P300_19829295_ChIP-Seq_ESCs_Human1.87786497
30SMAD4_21799915_ChIP-Seq_A2780_Human1.87237915
31REST_21632747_ChIP-Seq_MESCs_Mouse1.85356735
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76785330
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.76506596
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72373248
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71564716
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.69322876
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68497014
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64108360
39DROSHA_22980978_ChIP-Seq_HELA_Human1.62618338
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61327574
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.59208147
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59046455
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58157047
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57393571
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53837554
46AR_21572438_ChIP-Seq_LNCaP_Human1.52046436
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48627599
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47053301
49VDR_22108803_ChIP-Seq_LS180_Human1.42870165
50IGF1R_20145208_ChIP-Seq_DFB_Human1.42769512
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42625705
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42080540
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41158261
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.40496308
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.39388145
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.39292783
57HTT_18923047_ChIP-ChIP_STHdh_Human1.38587183
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38130302
59CBP_20019798_ChIP-Seq_JUKART_Human1.38130302
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37776823
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37460778
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37378633
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.37170045
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36880781
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.36006449
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.34081264
67TP53_18474530_ChIP-ChIP_U2OS_Human1.34074811
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.33201675
69AR_25329375_ChIP-Seq_VCAP_Human1.33168921
70RNF2_27304074_Chip-Seq_NSC_Mouse1.32200119
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.30847759
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30826021
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29760545
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29234863
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28536913
76P53_22387025_ChIP-Seq_ESCs_Mouse1.28313675
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28047725
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27181088
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.25677314
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25126311
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24268987
82STAT3_23295773_ChIP-Seq_U87_Human1.23156384
83EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23024351
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22835314
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21800182
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.20790395
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18826571
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18053157
89TCF4_22108803_ChIP-Seq_LS180_Human1.17460410
90TCF4_23295773_ChIP-Seq_U87_Human1.17215026
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16771436
92RUNX2_22187159_ChIP-Seq_PCA_Human1.16492699
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.15960348
94P300_18555785_Chip-Seq_ESCs_Mouse1.15174773
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15174531
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13988773
97NMYC_18555785_Chip-Seq_ESCs_Mouse1.13647136
98RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13268474
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.11828429
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11765880
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11620789
102* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11065117
103ER_23166858_ChIP-Seq_MCF-7_Human1.10960845
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10442153
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10442153
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10112105
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09558022
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.08990517
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.08209149
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07794111
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07045903
112PU1_27457419_Chip-Seq_LIVER_Mouse1.06789465
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.06633208
114BCAT_22108803_ChIP-Seq_LS180_Human1.06157804
115OCT4_18555785_Chip-Seq_ESCs_Mouse1.05448586
116TP53_16413492_ChIP-PET_HCT116_Human1.05075999
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04741202
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.04035746
119NANOG_19829295_ChIP-Seq_ESCs_Human1.03879956
120SOX2_19829295_ChIP-Seq_ESCs_Human1.03879956
121SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03417496
122KDM2B_26808549_Chip-Seq_REH_Human1.02867922
123EWS_26573619_Chip-Seq_HEK293_Human1.02802099
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.01002913
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00956517
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99216733
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98692359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.38558961
2MP0003880_abnormal_central_pattern3.07926586
3MP0009046_muscle_twitch2.85576102
4MP0001188_hyperpigmentation2.82530030
5MP0002735_abnormal_chemical_nociception2.82521427
6MP0002139_abnormal_hepatobiliary_system2.79769439
7MP0001968_abnormal_touch/_nociception2.78004854
8MP0006276_abnormal_autonomic_nervous2.72679974
9MP0005646_abnormal_pituitary_gland2.64710028
10MP0009745_abnormal_behavioral_response2.64478815
11MP0003635_abnormal_synaptic_transmissio2.63872644
12MP0002736_abnormal_nociception_after2.49894281
13MP0005085_abnormal_gallbladder_physiolo2.46691807
14MP0002102_abnormal_ear_morphology2.46600812
15MP0002272_abnormal_nervous_system2.46185049
16MP0002734_abnormal_mechanical_nocicepti2.32389858
17MP0005423_abnormal_somatic_nervous2.26877438
18MP0002064_seizures2.25818242
19MP0001486_abnormal_startle_reflex2.22236003
20MP0004270_analgesia2.16315561
21MP0002822_catalepsy2.15064099
22MP0009697_abnormal_copulation2.12162423
23MP0003283_abnormal_digestive_organ2.12134540
24MP0005187_abnormal_penis_morphology2.11438428
25MP0002572_abnormal_emotion/affect_behav2.09981840
26MP0002063_abnormal_learning/memory/cond2.00919521
27MP0003136_yellow_coat_color1.98965711
28MP0004142_abnormal_muscle_tone1.96891055
29MP0008875_abnormal_xenobiotic_pharmacok1.91060831
30MP0000566_synostosis1.86917826
31MP0001986_abnormal_taste_sensitivity1.83346198
32MP0001970_abnormal_pain_threshold1.81168824
33MP0001501_abnormal_sleep_pattern1.77532173
34MP0002067_abnormal_sensory_capabilities1.77233803
35MP0002733_abnormal_thermal_nociception1.77047891
36MP0005365_abnormal_bile_salt1.76870344
37MP0006072_abnormal_retinal_apoptosis1.75326998
38MP0004885_abnormal_endolymph1.72097002
39MP0002938_white_spotting1.70347424
40MP0001905_abnormal_dopamine_level1.68675899
41MP0004147_increased_porphyrin_level1.65484034
42MP0002638_abnormal_pupillary_reflex1.64451604
43MP0009379_abnormal_foot_pigmentation1.63767706
44MP0008877_abnormal_DNA_methylation1.63194627
45MP0005253_abnormal_eye_physiology1.58824541
46MP0001440_abnormal_grooming_behavior1.58777607
47MP0000631_abnormal_neuroendocrine_gland1.57861846
48MP0003787_abnormal_imprinting1.56250822
49MP0002837_dystrophic_cardiac_calcinosis1.53218880
50MP0005360_urolithiasis1.52381815
51MP0005645_abnormal_hypothalamus_physiol1.52250332
52MP0002557_abnormal_social/conspecific_i1.48226468
53MP0005409_darkened_coat_color1.45523594
54MP0002184_abnormal_innervation1.44936601
55MP0004133_heterotaxia1.44112405
56MP0002234_abnormal_pharynx_morphology1.43961913
57MP0010386_abnormal_urinary_bladder1.43797249
58MP0009780_abnormal_chondrocyte_physiolo1.42948022
59MP0003937_abnormal_limbs/digits/tail_de1.41364719
60MP0005367_renal/urinary_system_phenotyp1.41320234
61MP0000516_abnormal_urinary_system1.41320234
62MP0005551_abnormal_eye_electrophysiolog1.41065906
63MP0003890_abnormal_embryonic-extraembry1.38712354
64MP0003195_calcinosis1.37527995
65MP0004145_abnormal_muscle_electrophysio1.36993879
66MP0008569_lethality_at_weaning1.36167312
67MP0003121_genomic_imprinting1.32469492
68MP0000569_abnormal_digit_pigmentation1.31136129
69MP0003119_abnormal_digestive_system1.30333275
70MP0003252_abnormal_bile_duct1.28859537
71MP0006292_abnormal_olfactory_placode1.28804468
72MP0004924_abnormal_behavior1.25910895
73MP0005386_behavior/neurological_phenoty1.25910895
74MP0001984_abnormal_olfaction1.25863896
75MP0001177_atelectasis1.25389161
76MP0008872_abnormal_physiological_respon1.24836422
77MP0002909_abnormal_adrenal_gland1.23886931
78MP0001529_abnormal_vocalization1.23234189
79MP0004858_abnormal_nervous_system1.19340653
80MP0005083_abnormal_biliary_tract1.18079685
81MP0001502_abnormal_circadian_rhythm1.17628063
82MP0004215_abnormal_myocardial_fiber1.17466327
83MP0000955_abnormal_spinal_cord1.15921259
84MP0000049_abnormal_middle_ear1.15761164
85MP0003122_maternal_imprinting1.13489858
86MP0002876_abnormal_thyroid_physiology1.13349431
87MP0000579_abnormal_nail_morphology1.10812071
88MP0005171_absent_coat_pigmentation1.09860252
89MP0004043_abnormal_pH_regulation1.07401358
90MP0000538_abnormal_urinary_bladder1.06363901
91MP0002882_abnormal_neuron_morphology1.05556597
92MP0003941_abnormal_skin_development1.03970409
93MP0003567_abnormal_fetal_cardiomyocyte1.03233934
94MP0002160_abnormal_reproductive_system1.01340087
95MP0001963_abnormal_hearing_physiology0.98368667
96MP0002249_abnormal_larynx_morphology0.98204767
97MP0005535_abnormal_body_temperature0.97960001
98MP0001944_abnormal_pancreas_morphology0.97681325
99MP0003633_abnormal_nervous_system0.96542392
100MP0002066_abnormal_motor_capabilities/c0.95513080
101MP0003868_abnormal_feces_composition0.94421142
102MP0002751_abnormal_autonomic_nervous0.94293585
103MP0002928_abnormal_bile_duct0.93711661
104MP0003938_abnormal_ear_development0.93312414
105MP0005379_endocrine/exocrine_gland_phen0.92893884
106MP0002229_neurodegeneration0.92598638
107MP0000372_irregular_coat_pigmentation0.91961085
108MP0000427_abnormal_hair_cycle0.91742445
109MP0005195_abnormal_posterior_eye0.91736016
110MP0005075_abnormal_melanosome_morpholog0.91454158
111MP0000647_abnormal_sebaceous_gland0.91355961
112MP0008995_early_reproductive_senescence0.91023163
113MP0000015_abnormal_ear_pigmentation0.90746362
114MP0000026_abnormal_inner_ear0.90620664
115MP0004085_abnormal_heartbeat0.89977965
116MP0003690_abnormal_glial_cell0.88881970
117MP0004381_abnormal_hair_follicle0.88453336
118MP0003755_abnormal_palate_morphology0.87915928
119MP0008874_decreased_physiological_sensi0.87910550
120MP0001299_abnormal_eye_distance/0.87672055
121MP0002233_abnormal_nose_morphology0.86116095
122MP0000778_abnormal_nervous_system0.85662731
123MP0005391_vision/eye_phenotype0.85605810
124MP0000534_abnormal_ureter_morphology0.85378617
125MP0004811_abnormal_neuron_physiology0.84303904
126MP0003879_abnormal_hair_cell0.83748282
127MP0003631_nervous_system_phenotype0.83676448
128MP0003935_abnormal_craniofacial_develop0.83589463
129MP0001270_distended_abdomen0.83453931
130MP0003011_delayed_dark_adaptation0.82266624
131MP0002752_abnormal_somatic_nervous0.82197247
132MP0003861_abnormal_nervous_system0.81852217
133MP0005084_abnormal_gallbladder_morpholo0.79652878
134MP0004742_abnormal_vestibular_system0.78969303
135MP0001324_abnormal_eye_pigmentation0.78844007
136MP0000681_abnormal_thyroid_gland0.78762534
137* MP0002152_abnormal_brain_morphology0.78562390
138MP0005332_abnormal_amino_acid0.78243105
139MP0000639_abnormal_adrenal_gland0.77693018
140MP0005584_abnormal_enzyme/coenzyme_acti0.76092580
141MP0005503_abnormal_tendon_morphology0.75453054
142MP0009764_decreased_sensitivity_to0.73336872
143MP0003137_abnormal_impulse_conducting0.72559526
144MP0003656_abnormal_erythrocyte_physiolo0.71938639
145MP0010329_abnormal_lipoprotein_level0.70914276
146MP0004019_abnormal_vitamin_homeostasis0.69411927
147MP0001485_abnormal_pinna_reflex0.68074290
148MP0001764_abnormal_homeostasis0.65926902

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.50121010
2Febrile seizures (HP:0002373)5.15360279
3Focal motor seizures (HP:0011153)4.99688240
4Hypothermia (HP:0002045)4.04449907
5Progressive cerebellar ataxia (HP:0002073)4.02829853
6Prolonged partial thromboplastin time (HP:0003645)3.88843973
7Epileptic encephalopathy (HP:0200134)3.65540115
8Action tremor (HP:0002345)3.50057612
9Intestinal atresia (HP:0011100)3.47052461
10Focal seizures (HP:0007359)3.30080366
11Generalized tonic-clonic seizures (HP:0002069)3.20844448
12Atonic seizures (HP:0010819)3.15619106
13Limb dystonia (HP:0002451)3.07051727
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.03321522
15Hemiparesis (HP:0001269)2.97777292
16Hypoglycemic seizures (HP:0002173)2.97046394
17Hyperinsulinemic hypoglycemia (HP:0000825)2.95890516
18Medial flaring of the eyebrow (HP:0010747)2.94091294
19Conjugated hyperbilirubinemia (HP:0002908)2.93581277
20True hermaphroditism (HP:0010459)2.88652814
21Pancreatic cysts (HP:0001737)2.88561650
22Nephronophthisis (HP:0000090)2.85305663
23Absence seizures (HP:0002121)2.83202272
24Pancreatic fibrosis (HP:0100732)2.79952135
25Intrahepatic cholestasis (HP:0001406)2.79555949
26Hypoglycemic coma (HP:0001325)2.76622393
27Hyperventilation (HP:0002883)2.75317775
28Molar tooth sign on MRI (HP:0002419)2.73992812
29Abnormality of midbrain morphology (HP:0002418)2.73992812
30Generalized hypopigmentation of hair (HP:0011358)2.69392029
31Gait imbalance (HP:0002141)2.66205071
32Gaze-evoked nystagmus (HP:0000640)2.62870520
33Status epilepticus (HP:0002133)2.53694546
34Large for gestational age (HP:0001520)2.53345907
35Congenital primary aphakia (HP:0007707)2.47682974
36Hypokinesia (HP:0002375)2.45941307
37Fair hair (HP:0002286)2.42088382
38Dialeptic seizures (HP:0011146)2.37584730
39Ketoacidosis (HP:0001993)2.36645454
40Joint hemorrhage (HP:0005261)2.34513755
41Abnormality of the renal medulla (HP:0100957)2.32973525
42Scanning speech (HP:0002168)2.32772806
43Torticollis (HP:0000473)2.28620367
44Anophthalmia (HP:0000528)2.24388438
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.24241657
46Chronic hepatic failure (HP:0100626)2.22980127
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22889020
48Renal cortical cysts (HP:0000803)2.22636166
49Gastrointestinal atresia (HP:0002589)2.22113878
50Ulnar claw (HP:0001178)2.21953450
51Hypsarrhythmia (HP:0002521)2.19909031
52EEG with generalized epileptiform discharges (HP:0011198)2.18862009
53Nephrogenic diabetes insipidus (HP:0009806)2.18178053
54Anxiety (HP:0000739)2.18117216
55Epileptiform EEG discharges (HP:0011182)2.16444068
56Craniofacial dystonia (HP:0012179)2.16047803
57Focal dystonia (HP:0004373)2.14431981
58Pheochromocytoma (HP:0002666)2.13540735
59Hyperlipoproteinemia (HP:0010980)2.09785057
60Pancreatic islet-cell hyperplasia (HP:0004510)2.09347711
61Abnormality of methionine metabolism (HP:0010901)2.09012877
62Enlarged kidneys (HP:0000105)2.08848004
63Genetic anticipation (HP:0003743)2.07704210
64Dysdiadochokinesis (HP:0002075)2.06739364
65Visual hallucinations (HP:0002367)2.06476212
66Inability to walk (HP:0002540)2.06250233
67Thyroid-stimulating hormone excess (HP:0002925)2.06147668
68Abnormality of the labia minora (HP:0012880)2.05492861
69Abnormality of pyrimidine metabolism (HP:0004353)2.05487074
70Abnormality of the ischium (HP:0003174)2.04507020
71Optic nerve hypoplasia (HP:0000609)2.02532357
72Drooling (HP:0002307)2.01750098
73Ankle clonus (HP:0011448)2.01695231
74Type II lissencephaly (HP:0007260)2.00936273
75Cutaneous finger syndactyly (HP:0010554)1.98835494
76Septo-optic dysplasia (HP:0100842)1.98826506
77Aqueductal stenosis (HP:0002410)1.98820533
783-Methylglutaconic aciduria (HP:0003535)1.98791860
79Congenital malformation of the right heart (HP:0011723)1.98309418
80Double outlet right ventricle (HP:0001719)1.98309418
81Neonatal hypoglycemia (HP:0001998)1.98136928
82Hyperglycemia (HP:0003074)1.97470068
83Abnormality of the renal cortex (HP:0011035)1.96846304
84Abnormality of secondary sexual hair (HP:0009888)1.96671904
85Abnormality of the axillary hair (HP:0100134)1.96671904
86Absent speech (HP:0001344)1.95937367
87Enlarged penis (HP:0000040)1.95586728
88Postaxial hand polydactyly (HP:0001162)1.95184321
89Abnormality of the pancreatic islet cells (HP:0006476)1.94147590
90Abnormality of endocrine pancreas physiology (HP:0012093)1.94147590
91Osteomalacia (HP:0002749)1.92984425
92Deep venous thrombosis (HP:0002625)1.92682812
93Volvulus (HP:0002580)1.92431275
94Congenital stationary night blindness (HP:0007642)1.91727652
95Hypobetalipoproteinemia (HP:0003563)1.91695726
96Diminished movement (HP:0002374)1.90001576
97Poor coordination (HP:0002370)1.89920806
98Agitation (HP:0000713)1.89442911
99Cystic liver disease (HP:0006706)1.89176568
100Progressive inability to walk (HP:0002505)1.88520557
101Short tibia (HP:0005736)1.87841727
102Genital tract atresia (HP:0001827)1.87540490
103Oligodactyly (hands) (HP:0001180)1.87288303
104Abnormal pancreas size (HP:0012094)1.86641265
105Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86530714
106Hepatoblastoma (HP:0002884)1.85262823
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85114482
108Exotropia (HP:0000577)1.85028705
109Midline defect of the nose (HP:0004122)1.84630570
110Abnormality of calcium-phosphate metabolism (HP:0100530)1.84413354
111Fetal akinesia sequence (HP:0001989)1.84288029
112Sclerocornea (HP:0000647)1.83047331
113Neuroendocrine neoplasm (HP:0100634)1.82688638
114Acute necrotizing encephalopathy (HP:0006965)1.82118742
115Lissencephaly (HP:0001339)1.81538815
116Bradycardia (HP:0001662)1.81152153
117Occipital encephalocele (HP:0002085)1.79398797
118Abnormality of the parathyroid morphology (HP:0011766)1.78741233
119Bilateral microphthalmos (HP:0007633)1.78169771
120Esophageal atresia (HP:0002032)1.77745039
121Postural instability (HP:0002172)1.77672079
122Hypophosphatemic rickets (HP:0004912)1.77117090
123Dysmetria (HP:0001310)1.77039601
124Cholecystitis (HP:0001082)1.76399621
125Abnormal gallbladder physiology (HP:0012438)1.76399621
126Broad-based gait (HP:0002136)1.75738566
127Cerebellar dysplasia (HP:0007033)1.75716888
128Hyperbilirubinemia (HP:0002904)1.75510366
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75173335
130Keratoconus (HP:0000563)1.75081747
131Increased corneal curvature (HP:0100692)1.75081747
132Popliteal pterygium (HP:0009756)1.74808392
133Specific learning disability (HP:0001328)1.74632283
134Abnormality of the nasolacrimal system (HP:0000614)1.73907990
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73725616
136Acute encephalopathy (HP:0006846)1.73442606
137Anencephaly (HP:0002323)1.73356939
138Abnormal hair whorl (HP:0010721)1.73000509
139Renal Fanconi syndrome (HP:0001994)1.72929928
140Renal hypoplasia (HP:0000089)1.72906536
141Palpebral edema (HP:0100540)1.72736021
142Blue irides (HP:0000635)1.72662186
143Vaginal atresia (HP:0000148)1.72340618
144Excessive salivation (HP:0003781)1.71758351
145Abnormality of the astrocytes (HP:0100707)1.70181189
146Astrocytoma (HP:0009592)1.70181189
147Papilledema (HP:0001085)1.69189748
148Abnormality of the lacrimal duct (HP:0011481)1.68221253
149Postaxial foot polydactyly (HP:0001830)1.67818916
150Humeroradial synostosis (HP:0003041)1.67519870
151Synostosis involving the elbow (HP:0003938)1.67519870
152Shawl scrotum (HP:0000049)1.67206297
153Decreased central vision (HP:0007663)1.67045402
154Fat malabsorption (HP:0002630)1.66527617
155Tubulointerstitial nephritis (HP:0001970)1.66149815
156Optic disc pallor (HP:0000543)1.65870228
157Abnormal mitochondria in muscle tissue (HP:0008316)1.65620590
158Cutaneous syndactyly (HP:0012725)1.65310881
159Aplasia/hypoplasia of the uterus (HP:0008684)1.64274003
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.64141055
161Abnormality of serum amino acid levels (HP:0003112)1.64006083
162Abnormality of the corticospinal tract (HP:0002492)1.63156955
163Abnormality of the phalanges of the 2nd finger (HP:0009541)1.61489459
164Narrow forehead (HP:0000341)1.61317468
165Pachygyria (HP:0001302)1.60967546
166Abnormality of the metopic suture (HP:0005556)1.60914404
167Xanthomatosis (HP:0000991)1.60553155
168Truncal ataxia (HP:0002078)1.60525252
169Abnormality of the pubic bones (HP:0003172)1.60191686
170Impaired vibration sensation in the lower limbs (HP:0002166)1.59629736
171Methylmalonic acidemia (HP:0002912)1.59407050
172Myelomeningocele (HP:0002475)1.59009375
173Myotonia (HP:0002486)1.58950295
174Preaxial hand polydactyly (HP:0001177)1.58775952
175Progressive macrocephaly (HP:0004481)1.58638145
176Abnormal drinking behavior (HP:0030082)1.58054518
177Impaired pain sensation (HP:0007328)1.58028132
178Abnormality of pain sensation (HP:0010832)1.58028132
179Absent eyebrow (HP:0002223)1.56961515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.16176871
2NTRK34.27178747
3CASK3.74253549
4MAP2K73.66873889
5PNCK3.40602211
6MAP4K22.72588523
7TNIK2.72553380
8WNK32.38280553
9MINK12.34687705
10PINK12.32708714
11MAP3K42.28967962
12MAP3K122.27396097
13FGFR22.14818707
14AKT32.10210838
15MAP2K42.09767954
16TRIM281.90390472
17MAPKAPK51.90216475
18EPHA41.85968416
19GRK51.84454620
20BMPR1B1.79508193
21MAPK131.74345831
22STK161.70783462
23ZAK1.70449000
24NTRK21.68876802
25LMTK21.64083250
26SGK21.63765584
27INSRR1.60261070
28PLK21.52126278
29SGK2231.44261933
30SGK4941.44261933
31WEE11.40586508
32ADRBK21.37851289
33TNK21.34014719
34PAK31.32064662
35WNK11.30509201
36LATS21.29179179
37STK391.28457589
38NTRK11.24727808
39IRAK31.24361400
40OBSCN1.23613982
41ACVR1B1.23548398
42PRKCG1.21454434
43GRK11.20926061
44STK38L1.20134240
45NEK61.16442861
46MUSK1.15615749
47BCR1.14821034
48CSNK1G11.12190087
49CCNB11.11250695
50MARK11.07722622
51CAMK2A1.07140983
52CAMK2G1.06969913
53MKNK21.03743196
54SIK31.03222080
55GRK71.01728724
56WNK41.01168339
57BMPR21.00134580
58MAPK150.97060319
59STK380.95335579
60SGK30.95032489
61DYRK20.95012700
62NLK0.94843970
63PRKCE0.94081922
64TRPM70.92949215
65ERBB30.90867901
66ADRBK10.89653511
67CDK30.87731672
68STK240.85087366
69CAMK1G0.84381800
70CDK50.81649859
71CSNK1A1L0.80706147
72YES10.80312912
73CAMK2B0.79818649
74NUAK10.79509964
75PHKG10.78687154
76PHKG20.78687154
77DAPK20.77479016
78PASK0.77145086
79PRPF4B0.76592176
80MYLK0.76124709
81STK30.75337613
82LIMK10.74045394
83UHMK10.72892226
84PLK40.71803034
85CAMKK20.70483082
86PAK60.69698957
87CAMK2D0.69556460
88PKN10.68188198
89CAMKK10.64424842
90MAP3K20.64409740
91CAMK10.63170558
92OXSR10.62995188
93CSNK1G20.62671448
94TLK10.61797240
95TAOK30.61575675
96PLK30.61378584
97TSSK60.61297585
98ABL20.60800418
99PRKCH0.60660023
100MAP2K60.58924028
101PRKACA0.57946300
102PRKD30.57906804
103ERBB40.57157124
104IRAK20.56409072
105FER0.56143520
106CSNK1G30.54463757
107PRKAA10.54347785
108VRK10.52401142
109PBK0.52354868
110RPS6KB10.52318940
111CDK80.48981533
112BRSK10.48723417
113CDK180.48294742
114FES0.48136905
115NME10.47843423
116RPS6KA20.47587614
117TIE10.47486632
118NEK90.46942604
119EPHA30.46595150
120LATS10.45837227
121PRKCA0.45548344
122MAP3K140.44863208
123STK110.44665513
124CDC42BPA0.44489792
125PRKCQ0.43932437
126CDK150.42973166
127ERBB20.42345616
128PRKG10.42336580
129EIF2AK20.41363538
130DYRK30.41253595
131ROCK10.41204978
132MAPK40.40983703
133MKNK10.40859278
134CSNK1A10.40671803
135PRKACB0.40585926
136CAMK1D0.40412239
137SGK10.40211030
138DYRK1A0.40063835
139CAMK40.39252814
140PTK2B0.38480951
141CDK140.38080811
142PRKCZ0.37780363
143BRD40.36175248
144NEK20.35230657
145EPHB20.34189546
146CSNK1E0.33535324
147TGFBR10.32104676
148CSNK1D0.30942599
149PIK3CA0.28806299

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.84867889
2Nicotine addiction_Homo sapiens_hsa050333.11427118
3Nitrogen metabolism_Homo sapiens_hsa009102.91836514
4Synaptic vesicle cycle_Homo sapiens_hsa047212.53126379
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.42223191
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36362707
7Protein export_Homo sapiens_hsa030602.29138650
8Taste transduction_Homo sapiens_hsa047422.03088337
9GABAergic synapse_Homo sapiens_hsa047271.99993563
10Tryptophan metabolism_Homo sapiens_hsa003801.92254363
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86446782
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82496782
13Glutamatergic synapse_Homo sapiens_hsa047241.80955986
14Olfactory transduction_Homo sapiens_hsa047401.80855206
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78137565
16Arginine biosynthesis_Homo sapiens_hsa002201.75591594
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.70253217
18Morphine addiction_Homo sapiens_hsa050321.69027485
19Tyrosine metabolism_Homo sapiens_hsa003501.66064949
20Oxidative phosphorylation_Homo sapiens_hsa001901.61143091
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60008131
22Retinol metabolism_Homo sapiens_hsa008301.59931517
23Circadian entrainment_Homo sapiens_hsa047131.59108375
24Vitamin B6 metabolism_Homo sapiens_hsa007501.54700774
25Fatty acid elongation_Homo sapiens_hsa000621.54499972
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53840974
27Serotonergic synapse_Homo sapiens_hsa047261.51069811
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50361149
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49740282
30Phenylalanine metabolism_Homo sapiens_hsa003601.49141444
31Peroxisome_Homo sapiens_hsa041461.48790283
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44630088
33Histidine metabolism_Homo sapiens_hsa003401.44435344
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44375402
35Selenocompound metabolism_Homo sapiens_hsa004501.44285933
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37786757
37Sulfur metabolism_Homo sapiens_hsa009201.34816581
38Insulin secretion_Homo sapiens_hsa049111.33575616
39Butanoate metabolism_Homo sapiens_hsa006501.33549137
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33222496
41Parkinsons disease_Homo sapiens_hsa050121.31264813
42Regulation of autophagy_Homo sapiens_hsa041401.30560464
43beta-Alanine metabolism_Homo sapiens_hsa004101.29663756
44Amphetamine addiction_Homo sapiens_hsa050311.28535876
45Bile secretion_Homo sapiens_hsa049761.28218504
46Complement and coagulation cascades_Homo sapiens_hsa046101.28216218
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23160568
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21750602
49Phototransduction_Homo sapiens_hsa047441.20070873
50Fatty acid degradation_Homo sapiens_hsa000711.19738692
51Salivary secretion_Homo sapiens_hsa049701.18192225
52Basal transcription factors_Homo sapiens_hsa030221.18138359
53Steroid biosynthesis_Homo sapiens_hsa001001.17759253
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15541198
55Chemical carcinogenesis_Homo sapiens_hsa052041.15165403
56Dopaminergic synapse_Homo sapiens_hsa047281.14450229
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11069044
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09207091
59Type II diabetes mellitus_Homo sapiens_hsa049301.06233859
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04372209
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03415293
62Collecting duct acid secretion_Homo sapiens_hsa049661.03368018
63Hedgehog signaling pathway_Homo sapiens_hsa043401.01077045
64Alzheimers disease_Homo sapiens_hsa050101.00360343
65Linoleic acid metabolism_Homo sapiens_hsa005911.00171934
66ABC transporters_Homo sapiens_hsa020101.00017447
67Long-term depression_Homo sapiens_hsa047300.99341782
68Starch and sucrose metabolism_Homo sapiens_hsa005000.97756512
69Fanconi anemia pathway_Homo sapiens_hsa034600.97059330
70Cholinergic synapse_Homo sapiens_hsa047250.95923746
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95583088
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95177182
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93310219
74Fatty acid metabolism_Homo sapiens_hsa012120.92710797
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91726296
76Cardiac muscle contraction_Homo sapiens_hsa042600.89919186
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88494200
78Basal cell carcinoma_Homo sapiens_hsa052170.87504691
79Hippo signaling pathway_Homo sapiens_hsa043900.86974508
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86081363
81Calcium signaling pathway_Homo sapiens_hsa040200.86065778
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.85806684
83Propanoate metabolism_Homo sapiens_hsa006400.84175083
84Non-homologous end-joining_Homo sapiens_hsa034500.83577453
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83034368
86Cocaine addiction_Homo sapiens_hsa050300.81079396
87* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80731846
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80050348
89Axon guidance_Homo sapiens_hsa043600.78884522
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78320283
91* TGF-beta signaling pathway_Homo sapiens_hsa043500.78308452
92Homologous recombination_Homo sapiens_hsa034400.77587921
93Gastric acid secretion_Homo sapiens_hsa049710.77292516
94Long-term potentiation_Homo sapiens_hsa047200.74044431
95Ovarian steroidogenesis_Homo sapiens_hsa049130.73547645
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72920338
97Arginine and proline metabolism_Homo sapiens_hsa003300.72422387
98Lysine degradation_Homo sapiens_hsa003100.72360813
99RNA degradation_Homo sapiens_hsa030180.71578124
100PPAR signaling pathway_Homo sapiens_hsa033200.71253400
101Huntingtons disease_Homo sapiens_hsa050160.71087430
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67682634
103Oocyte meiosis_Homo sapiens_hsa041140.67228352
104Wnt signaling pathway_Homo sapiens_hsa043100.64852861
105Fatty acid biosynthesis_Homo sapiens_hsa000610.62826197
106Dorso-ventral axis formation_Homo sapiens_hsa043200.59723640
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58650507
108Metabolic pathways_Homo sapiens_hsa011000.58305010
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.57616503
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56074196
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55203912
112Mineral absorption_Homo sapiens_hsa049780.55117125
113Caffeine metabolism_Homo sapiens_hsa002320.50633084
114cAMP signaling pathway_Homo sapiens_hsa040240.50487622
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49924795
116RNA polymerase_Homo sapiens_hsa030200.48633577
117Thyroid hormone synthesis_Homo sapiens_hsa049180.48457847
118Folate biosynthesis_Homo sapiens_hsa007900.48414482
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47499228
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47176837
121Pyruvate metabolism_Homo sapiens_hsa006200.46085211
122Renin secretion_Homo sapiens_hsa049240.44742018
123Alcoholism_Homo sapiens_hsa050340.44150151
124Glucagon signaling pathway_Homo sapiens_hsa049220.43808951
125Fat digestion and absorption_Homo sapiens_hsa049750.43620811
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43404696
127Pancreatic secretion_Homo sapiens_hsa049720.42298425
128Circadian rhythm_Homo sapiens_hsa047100.40626726
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39333138
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37349152
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.34553793
132Gap junction_Homo sapiens_hsa045400.32907163
133Ether lipid metabolism_Homo sapiens_hsa005650.31521886
134Oxytocin signaling pathway_Homo sapiens_hsa049210.31502868
135Melanogenesis_Homo sapiens_hsa049160.30520154

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