SMAGP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.86933327
2cysteine metabolic process (GO:0006534)4.94208329
3establishment of protein localization to mitochondrial membrane (GO:0090151)4.92429048
4sulfur amino acid catabolic process (GO:0000098)4.71952443
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.61465208
6tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.61465208
7L-phenylalanine metabolic process (GO:0006558)4.55954039
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.55954039
9L-phenylalanine catabolic process (GO:0006559)4.42861033
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.42861033
11urea metabolic process (GO:0019627)4.31580805
12urea cycle (GO:0000050)4.31580805
13serine family amino acid catabolic process (GO:0009071)4.23674706
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.16393582
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.15300803
16protein complex biogenesis (GO:0070271)4.15188645
17drug catabolic process (GO:0042737)4.12874662
18aromatic amino acid family catabolic process (GO:0009074)4.12075525
19platelet dense granule organization (GO:0060155)4.05607142
20NADH dehydrogenase complex assembly (GO:0010257)4.02620938
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02620938
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.02620938
23kynurenine metabolic process (GO:0070189)3.96190219
24nitrogen cycle metabolic process (GO:0071941)3.94430574
25indole-containing compound catabolic process (GO:0042436)3.93914526
26indolalkylamine catabolic process (GO:0046218)3.93914526
27tryptophan catabolic process (GO:0006569)3.93914526
28DNA deamination (GO:0045006)3.89918999
29keratinocyte development (GO:0003334)3.89878694
30mitochondrial respiratory chain complex assembly (GO:0033108)3.88389740
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87382132
32ATP synthesis coupled proton transport (GO:0015986)3.87382132
33chaperone-mediated protein transport (GO:0072321)3.86716558
34urate metabolic process (GO:0046415)3.84873580
35protein-cofactor linkage (GO:0018065)3.81795177
36homocysteine metabolic process (GO:0050667)3.80456327
37pseudouridine synthesis (GO:0001522)3.78254586
38lysine catabolic process (GO:0006554)3.77241947
39lysine metabolic process (GO:0006553)3.77241947
40glyoxylate metabolic process (GO:0046487)3.75850209
41respiratory chain complex IV assembly (GO:0008535)3.72724177
42intestinal epithelial cell development (GO:0060576)3.71304710
43tryptophan metabolic process (GO:0006568)3.71061852
44mannosylation (GO:0097502)3.61218778
45amino-acid betaine metabolic process (GO:0006577)3.58436620
46high-density lipoprotein particle remodeling (GO:0034375)3.58049366
47complement activation, alternative pathway (GO:0006957)3.57019056
48bile acid and bile salt transport (GO:0015721)3.53143678
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52401804
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.49688978
51cytochrome complex assembly (GO:0017004)3.49352215
52glycine metabolic process (GO:0006544)3.48691904
53serine family amino acid metabolic process (GO:0009069)3.42700719
54regulation of protein activation cascade (GO:2000257)3.41721542
55peptidyl-histidine modification (GO:0018202)3.41703635
56regulation of triglyceride catabolic process (GO:0010896)3.41018131
57water-soluble vitamin biosynthetic process (GO:0042364)3.39733025
58rRNA modification (GO:0000154)3.39127730
59negative regulation of sterol transport (GO:0032372)3.38939308
60negative regulation of cholesterol transport (GO:0032375)3.38939308
61folic acid metabolic process (GO:0046655)3.37578120
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36384466
63bile acid biosynthetic process (GO:0006699)3.32738163
64negative regulation of fibrinolysis (GO:0051918)3.32230848
65regulation of cellular amino acid metabolic process (GO:0006521)3.31933100
66acylglycerol homeostasis (GO:0055090)3.29701613
67triglyceride homeostasis (GO:0070328)3.29701613
68mitochondrial RNA metabolic process (GO:0000959)3.28820671
69regulation of cholesterol esterification (GO:0010872)3.28188393
70regulation of complement activation (GO:0030449)3.26990329
71cellular ketone body metabolic process (GO:0046950)3.24651464
72positive regulation of lipoprotein lipase activity (GO:0051006)3.23781051
73positive regulation of triglyceride lipase activity (GO:0061365)3.23781051
74peptidyl-glutamic acid carboxylation (GO:0017187)3.20535131
75protein carboxylation (GO:0018214)3.20535131
76phospholipid efflux (GO:0033700)3.19884275
77tRNA processing (GO:0008033)3.17820117
78regulation of cholesterol homeostasis (GO:2000188)3.17767887
79transcytosis (GO:0045056)3.17086841
80intestinal absorption (GO:0050892)3.16693485
81cullin deneddylation (GO:0010388)3.15746663
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15706441
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14450334
84reverse cholesterol transport (GO:0043691)3.12736133
85negative regulation of fatty acid biosynthetic process (GO:0045717)3.12726147
86aromatic amino acid family metabolic process (GO:0009072)3.12587881
87tRNA modification (GO:0006400)3.12095041
88bile acid metabolic process (GO:0008206)3.11356404
89preassembly of GPI anchor in ER membrane (GO:0016254)3.11272736
90negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.10969799
91serine family amino acid biosynthetic process (GO:0009070)3.09281644
92protein deneddylation (GO:0000338)3.08612819
93adenosine metabolic process (GO:0046085)3.08151590
94L-methionine salvage (GO:0071267)3.07042742
95L-methionine biosynthetic process (GO:0071265)3.07042742
96amino acid salvage (GO:0043102)3.07042742
97regulation of bile acid biosynthetic process (GO:0070857)3.04738718
98regulation of mitochondrial translation (GO:0070129)3.03059100
99nucleotide transmembrane transport (GO:1901679)3.02857967
100electron transport chain (GO:0022900)3.02840280
101ethanol oxidation (GO:0006069)3.01828475
102exogenous drug catabolic process (GO:0042738)3.01276830
103bundle of His cell to Purkinje myocyte communication (GO:0086069)3.00803840
104respiratory electron transport chain (GO:0022904)2.99274560
105sterol homeostasis (GO:0055092)2.98586837
106mitotic metaphase plate congression (GO:0007080)2.96605708
107cholesterol homeostasis (GO:0042632)2.95758175
108one-carbon metabolic process (GO:0006730)2.95328964
109drug transmembrane transport (GO:0006855)2.95177909
110regulation of fibrinolysis (GO:0051917)2.95039233
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94394788
112plasma lipoprotein particle remodeling (GO:0034369)2.94363837
113protein-lipid complex remodeling (GO:0034368)2.94363837
114macromolecular complex remodeling (GO:0034367)2.94363837
115DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93919844
116alpha-linolenic acid metabolic process (GO:0036109)2.92938602
117alpha-amino acid catabolic process (GO:1901606)2.92672070
118protein targeting to mitochondrion (GO:0006626)2.91957189
119L-fucose catabolic process (GO:0042355)2.91306853
120fucose catabolic process (GO:0019317)2.91306853
121L-fucose metabolic process (GO:0042354)2.91306853
122rRNA methylation (GO:0031167)2.91242367
123dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.90272116
124fat-soluble vitamin biosynthetic process (GO:0042362)2.89946275
125arginine metabolic process (GO:0006525)2.88988411
126complement activation, classical pathway (GO:0006958)2.88494544
127inner mitochondrial membrane organization (GO:0007007)2.87639524
128cellular modified amino acid catabolic process (GO:0042219)2.86007410
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83742838
130signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83440092
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83440092
132signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83440092
133sulfur amino acid metabolic process (GO:0000096)2.82987298
134cellular amino acid catabolic process (GO:0009063)2.82093632
135plasma lipoprotein particle clearance (GO:0034381)2.81035484
136negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.80613982
137intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80521834
138signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80521834
139complement activation (GO:0006956)2.80156016
140nucleoside transmembrane transport (GO:1901642)2.79405259
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79218614
142negative regulation of ligase activity (GO:0051352)2.79218614
143mitotic chromosome condensation (GO:0007076)2.78576666
144termination of RNA polymerase III transcription (GO:0006386)2.78108197
145transcription elongation from RNA polymerase III promoter (GO:0006385)2.78108197
146positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77724788
147regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.75956163
148establishment of protein localization to mitochondrion (GO:0072655)2.75793384
149primary alcohol catabolic process (GO:0034310)2.75224206
150flavonoid metabolic process (GO:0009812)2.74430724
151anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74345918
152interferon-gamma secretion (GO:0072643)2.74143641
153intestinal cholesterol absorption (GO:0030299)2.73979500
154ubiquinone biosynthetic process (GO:0006744)2.73364060
155desmosome organization (GO:0002934)2.72635506
156phospholipid homeostasis (GO:0055091)2.72634018
157ketone body metabolic process (GO:1902224)2.71791039
158carnitine metabolic process (GO:0009437)2.71790047
159drug transport (GO:0015893)2.71687863
160sphingosine metabolic process (GO:0006670)2.70881686
161C-terminal protein lipidation (GO:0006501)2.69796574
162ethanol metabolic process (GO:0006067)2.69138108
163intracellular protein transmembrane import (GO:0044743)2.68043094
164signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66920306
165signal transduction involved in DNA damage checkpoint (GO:0072422)2.66920306
166negative regulation of telomere maintenance (GO:0032205)2.66679461
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66673632
168galactose metabolic process (GO:0006012)2.66304105
169response to nitrosative stress (GO:0051409)2.66255131
170tRNA metabolic process (GO:0006399)2.66113914
171lipoprotein metabolic process (GO:0042157)2.65674091
172signal transduction involved in cell cycle checkpoint (GO:0072395)2.65491031
173cellular biogenic amine catabolic process (GO:0042402)2.65329643
174amine catabolic process (GO:0009310)2.65329643
175protein localization to mitochondrion (GO:0070585)2.65263772
176positive regulation of ligase activity (GO:0051351)2.64277886
177benzene-containing compound metabolic process (GO:0042537)2.64271479
178regulation of histone H3-K27 methylation (GO:0061085)2.64002922
179diol metabolic process (GO:0034311)2.63181841
180piRNA metabolic process (GO:0034587)2.62692841
181GPI anchor metabolic process (GO:0006505)2.59726938
182exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59655495
183GDP-mannose metabolic process (GO:0019673)2.58337612
184purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56341672
185GPI anchor biosynthetic process (GO:0006506)2.52539091
186ATP biosynthetic process (GO:0006754)2.52378501
187purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.52187176
188GTP biosynthetic process (GO:0006183)2.51581316
189hydrogen ion transmembrane transport (GO:1902600)2.50955509
190response to pheromone (GO:0019236)2.50751256
191maturation of 5.8S rRNA (GO:0000460)2.49742784
192negative regulation of keratinocyte proliferation (GO:0010839)2.48506683
193iron-sulfur cluster assembly (GO:0016226)2.47728903
194metallo-sulfur cluster assembly (GO:0031163)2.47728903
195pteridine-containing compound biosynthetic process (GO:0042559)2.46862109
196behavioral response to nicotine (GO:0035095)2.46287605
197C-terminal protein amino acid modification (GO:0018410)2.43508087
198proton transport (GO:0015992)2.43487416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.31076560
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.82098582
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.76736492
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.72498200
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.37366024
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.93764543
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.88162136
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.59373751
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.58432804
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.55157424
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35431375
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19675873
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.14150854
14ZNF274_21170338_ChIP-Seq_K562_Hela3.11596441
15VDR_22108803_ChIP-Seq_LS180_Human3.00609007
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.98270205
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.87230340
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74788003
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56589367
20AR_21909140_ChIP-Seq_LNCAP_Human2.55817386
21ELK1_19687146_ChIP-ChIP_HELA_Human2.53874236
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.50810947
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.47731238
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.46700466
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.42839555
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40490791
27VDR_23849224_ChIP-Seq_CD4+_Human2.39990040
28* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21075175
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.08845244
30FOXP3_21729870_ChIP-Seq_TREG_Human1.98739393
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96881848
32KAP1_22055183_ChIP-Seq_ESCs_Mouse1.96548183
33GABP_19822575_ChIP-Seq_HepG2_Human1.96514008
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88795921
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88291831
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.85973710
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84531929
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81779130
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.81153879
40* DCP1A_22483619_ChIP-Seq_HELA_Human1.80796461
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79990856
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76365446
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73622503
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71694246
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67700345
46ZNF263_19887448_ChIP-Seq_K562_Human1.67588637
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65319522
48GATA4_25053715_ChIP-Seq_YYC3_Human1.63595089
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63455167
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63079514
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58942812
52* GATA6_25053715_ChIP-Seq_YYC3_Human1.58897218
53MYC_18940864_ChIP-ChIP_HL60_Human1.54666909
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53212316
55ATF3_27146783_Chip-Seq_COLON_Human1.52616553
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.50371699
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50339359
58E2F7_22180533_ChIP-Seq_HELA_Human1.50000692
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.49711247
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49244200
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48624778
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45150251
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42671410
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41206112
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40874542
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38736313
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.36785698
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35108394
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35022808
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34904302
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.34904302
72AR_20517297_ChIP-Seq_VCAP_Human1.34322125
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33479034
74* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29846306
75* TP53_22573176_ChIP-Seq_HFKS_Human1.29326992
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28395017
77* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28064703
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.26430211
79TTF2_22483619_ChIP-Seq_HELA_Human1.25075740
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24603526
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24603526
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24603526
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24499321
84CLOCK_20551151_ChIP-Seq_293T_Human1.19837963
85HOXB7_26014856_ChIP-Seq_BT474_Human1.17504943
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17000041
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16952036
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16410814
89NCOR_22424771_ChIP-Seq_293T_Human1.15120022
90* GATA3_21878914_ChIP-Seq_MCF-7_Human1.15115778
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13585406
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.10649037
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.10080635
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10066132
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09540898
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09108762
97PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08948488
98NANOG_20526341_ChIP-Seq_ESCs_Human1.08326509
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07554963
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07036602
101TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06233823
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05693594
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05463251
104HNF4A_19822575_ChIP-Seq_HepG2_Human1.05056677
105E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04853210
106ELF5_23300383_ChIP-Seq_T47D_Human1.03489857
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02966540
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02873605
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02844957
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02570773
111ERG_20517297_ChIP-Seq_VCAP_Human1.02493250
112FOXH1_21741376_ChIP-Seq_EPCs_Human1.01909242
113SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01012760
114CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99908733
115CDX2_22108803_ChIP-Seq_LS180_Human0.99793937
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99349725
117NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98741330
118* ERA_21632823_ChIP-Seq_H3396_Human0.96848840
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.96477090
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95829940
121HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95672975
122FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95417124
123KAP1_27257070_Chip-Seq_ESCs_Mouse0.94310995
124IRF1_19129219_ChIP-ChIP_H3396_Human0.94291716
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93141674
126FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92880489
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92402385
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91402491
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91084388
130EWS_26573619_Chip-Seq_HEK293_Human0.90881090
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90693718
132RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90598214
133NANOG_19829295_ChIP-Seq_ESCs_Human0.90536410
134SOX2_19829295_ChIP-Seq_ESCs_Human0.90536410
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90237202
136* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89527986
137RUNX1_27514584_Chip-Seq_MCF-7_Human0.89071605
138* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88787783
139MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88587791
140P53_21459846_ChIP-Seq_SAOS-2_Human0.88086768
141SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87459904
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87398621
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.87210875
144SOX2_20726797_ChIP-Seq_SW620_Human0.86282382
145XRN2_22483619_ChIP-Seq_HELA_Human0.85959385
146FOXH1_21741376_ChIP-Seq_ESCs_Human0.85858733
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.85551507
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85389760
149CBP_20019798_ChIP-Seq_JUKART_Human0.85389760
150NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85188309
151* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85004867
152ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84471367
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.84213342
154NANOG_18692474_ChIP-Seq_MESCs_Mouse0.83798639
155EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83750350
156FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83447209
157MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83319189
158EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83190138
159MYC_18555785_ChIP-Seq_MESCs_Mouse0.83028171
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82340653
161MYC_22102868_ChIP-Seq_BL_Human0.82071808
162P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79515977
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78381823
164CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77975859
165NELFA_20434984_ChIP-Seq_ESCs_Mouse0.77458425
166E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76366568
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.74619097
168POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.72543425
169DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72311706
170TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.72144417
171KDM5A_27292631_Chip-Seq_BREAST_Human0.71922093
172ELK3_25401928_ChIP-Seq_HUVEC_Human0.71649500
173* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71168611
174SALL1_21062744_ChIP-ChIP_HESCs_Human0.71001796
175E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69912760
176PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69906303
177NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.69775857
178BCOR_27268052_Chip-Seq_Bcells_Human0.69629073
179BP1_19119308_ChIP-ChIP_Hs578T_Human0.67633269
180FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67298992
181EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.67274233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.41781439
2MP0002139_abnormal_hepatobiliary_system5.10861956
3MP0005085_abnormal_gallbladder_physiolo3.94070105
4MP0005365_abnormal_bile_salt3.69571297
5MP0005451_abnormal_body_composition3.44717026
6MP0009840_abnormal_foam_cell3.28077764
7MP0008875_abnormal_xenobiotic_pharmacok3.22152240
8MP0010234_abnormal_vibrissa_follicle3.02953901
9MP0003718_maternal_effect2.85457393
10MP0003806_abnormal_nucleotide_metabolis2.76812292
11MP0004147_increased_porphyrin_level2.65937910
12MP0008995_early_reproductive_senescence2.43733990
13MP0003786_premature_aging2.42969060
14MP0002876_abnormal_thyroid_physiology2.37763641
15MP0001666_abnormal_nutrient_absorption2.34835699
16MP0004264_abnormal_extraembryonic_tissu2.33247697
17MP0003252_abnormal_bile_duct2.29473480
18MP0003705_abnormal_hypodermis_morpholog2.25980103
19MP0006292_abnormal_olfactory_placode2.22240508
20MP0003693_abnormal_embryo_hatching2.19138841
21MP0008872_abnormal_physiological_respon2.17522571
22MP0010329_abnormal_lipoprotein_level2.09196296
23MP0002796_impaired_skin_barrier2.05396061
24MP0004019_abnormal_vitamin_homeostasis2.05326665
25MP0003950_abnormal_plasma_membrane2.01467945
26MP0003191_abnormal_cellular_cholesterol2.00632466
27MP0004043_abnormal_pH_regulation1.99093268
28MP0004885_abnormal_endolymph1.99006966
29MP0005332_abnormal_amino_acid1.97653662
30MP0009697_abnormal_copulation1.96413676
31MP0000516_abnormal_urinary_system1.95992500
32MP0005367_renal/urinary_system_phenotyp1.95992500
33MP0000647_abnormal_sebaceous_gland1.88363729
34MP0002138_abnormal_hepatobiliary_system1.86509620
35MP0002938_white_spotting1.84965857
36MP0002837_dystrophic_cardiac_calcinosis1.79604546
37MP0002736_abnormal_nociception_after1.74133724
38MP0005084_abnormal_gallbladder_morpholo1.74109089
39MP0005646_abnormal_pituitary_gland1.70794871
40MP0002102_abnormal_ear_morphology1.63904195
41MP0008058_abnormal_DNA_repair1.62719318
42MP0003646_muscle_fatigue1.61003606
43MP0005395_other_phenotype1.55220213
44MP0000609_abnormal_liver_physiology1.53012650
45MP0010368_abnormal_lymphatic_system1.51312193
46MP0005551_abnormal_eye_electrophysiolog1.49292087
47MP0009780_abnormal_chondrocyte_physiolo1.49150457
48MP0003453_abnormal_keratinocyte_physiol1.46465684
49MP0009643_abnormal_urine_homeostasis1.46194551
50MP0004957_abnormal_blastocyst_morpholog1.45062208
51MP0010030_abnormal_orbit_morphology1.42246063
52MP0001986_abnormal_taste_sensitivity1.42244329
53MP0002163_abnormal_gland_morphology1.40053105
54MP0008004_abnormal_stomach_pH1.39990577
55MP0000427_abnormal_hair_cycle1.39913123
56MP0006054_spinal_hemorrhage1.38398125
57MP0002160_abnormal_reproductive_system1.37460221
58MP0002277_abnormal_respiratory_mucosa1.37295758
59MP0002234_abnormal_pharynx_morphology1.35188102
60MP0005083_abnormal_biliary_tract1.33614255
61MP0005408_hypopigmentation1.33165392
62MP0000383_abnormal_hair_follicle1.29251767
63MP0000613_abnormal_salivary_gland1.28701743
64MP0000467_abnormal_esophagus_morphology1.23164683
65MP0005501_abnormal_skin_physiology1.22436492
66MP0000372_irregular_coat_pigmentation1.21978899
67MP0000579_abnormal_nail_morphology1.21935032
68MP0003186_abnormal_redox_activity1.21155013
69MP0006072_abnormal_retinal_apoptosis1.21045610
70MP0008877_abnormal_DNA_methylation1.20961880
71MP0003195_calcinosis1.20144005
72MP0001968_abnormal_touch/_nociception1.19989599
73MP0002118_abnormal_lipid_homeostasis1.18567662
74MP0004185_abnormal_adipocyte_glucose1.18212899
75MP0005319_abnormal_enzyme/_coenzyme1.17729722
76MP0001756_abnormal_urination1.17362693
77MP0001661_extended_life_span1.14316749
78MP0002132_abnormal_respiratory_system1.13792947
79MP0002653_abnormal_ependyma_morphology1.12831248
80MP0004782_abnormal_surfactant_physiolog1.12133878
81MP0003111_abnormal_nucleus_morphology1.12086524
82MP0000537_abnormal_urethra_morphology1.11993575
83MP0002254_reproductive_system_inflammat1.11499052
84MP0003868_abnormal_feces_composition1.10615179
85MP0000490_abnormal_crypts_of1.10028145
86MP0003119_abnormal_digestive_system1.08637645
87MP0005389_reproductive_system_phenotype1.08594853
88MP0000013_abnormal_adipose_tissue1.07822015
89MP0010352_gastrointestinal_tract_polyps1.06524468
90MP0003937_abnormal_limbs/digits/tail_de1.04820003
91MP0003077_abnormal_cell_cycle1.02676495
92MP0001216_abnormal_epidermal_layer1.01416978
93MP0002136_abnormal_kidney_physiology0.99364853
94MP0003638_abnormal_response/metabolism_0.97940562
95MP0003699_abnormal_female_reproductive0.97670924
96MP0002282_abnormal_trachea_morphology0.96522561
97MP0002098_abnormal_vibrissa_morphology0.96356064
98MP0003566_abnormal_cell_adhesion0.94527320
99MP0001879_abnormal_lymphatic_vessel0.93969660
100MP0005410_abnormal_fertilization0.93917229
101MP0005023_abnormal_wound_healing0.93754874
102MP0008775_abnormal_heart_ventricle0.93565437
103MP0001243_abnormal_dermal_layer0.93551029
104MP0001764_abnormal_homeostasis0.93453844
105MP0002210_abnormal_sex_determination0.92030219
106MP0000598_abnormal_liver_morphology0.91298314
107MP0001119_abnormal_female_reproductive0.91197024
108MP0001905_abnormal_dopamine_level0.87520885
109MP0005636_abnormal_mineral_homeostasis0.87470049
110MP0008007_abnormal_cellular_replicative0.87280407
111MP0010678_abnormal_skin_adnexa0.87041624
112MP0001849_ear_inflammation0.86797026
113MP0000477_abnormal_intestine_morphology0.86535124
114MP0001730_embryonic_growth_arrest0.85075975
115MP0005647_abnormal_sex_gland0.84153046
116MP0001542_abnormal_bone_strength0.83980986
117MP0002060_abnormal_skin_morphology0.82520129
118MP0003943_abnormal_hepatobiliary_system0.81033709
119MP0001919_abnormal_reproductive_system0.80377294
120MP0000678_abnormal_parathyroid_gland0.79876363
121MP0010771_integument_phenotype0.79217051
122MP0000230_abnormal_systemic_arterial0.78850737
123MP0003936_abnormal_reproductive_system0.78783439
124MP0000377_abnormal_hair_follicle0.78120696
125MP0000462_abnormal_digestive_system0.77771132
126MP0010155_abnormal_intestine_physiology0.75980252
127MP0001915_intracranial_hemorrhage0.75747973
128MP0004133_heterotaxia0.74790414
129MP0000049_abnormal_middle_ear0.74462974
130MP0004947_skin_inflammation0.74327001
131MP0005253_abnormal_eye_physiology0.72833468
132MP0002086_abnormal_extraembryonic_tissu0.72021204
133MP0009053_abnormal_anal_canal0.70680695
134MP0005666_abnormal_adipose_tissue0.70150101
135MP0003315_abnormal_perineum_morphology0.69430548
136MP0001765_abnormal_ion_homeostasis0.67188447
137MP0005584_abnormal_enzyme/coenzyme_acti0.66232586
138MP0005380_embryogenesis_phenotype0.66067194
139MP0001672_abnormal_embryogenesis/_devel0.66067194
140MP0010094_abnormal_chromosome_stability0.65510294
141MP0003011_delayed_dark_adaptation0.65275145
142MP0001873_stomach_inflammation0.64807378
143MP0003300_gastrointestinal_ulcer0.64253224
144MP0009763_increased_sensitivity_to0.62835669
145MP0005310_abnormal_salivary_gland0.61688877
146MP0000653_abnormal_sex_gland0.60076699
147MP0002019_abnormal_tumor_incidence0.58212264
148MP0002088_abnormal_embryonic_growth/wei0.57713923
149MP0003984_embryonic_growth_retardation0.57310596
150MP0001697_abnormal_embryo_size0.57030741
151MP0005058_abnormal_lysosome_morphology0.56375054
152MP0009931_abnormal_skin_appearance0.56115311
153MP0009764_decreased_sensitivity_to0.55798618
154MP0000566_synostosis0.55780358
155MP0005167_abnormal_blood-brain_barrier0.55554093
156MP0003656_abnormal_erythrocyte_physiolo0.54945952
157MP0000538_abnormal_urinary_bladder0.54806721
158MP0005670_abnormal_white_adipose0.54334449
159MP0002168_other_aberrant_phenotype0.53588008
160MP0006036_abnormal_mitochondrial_physio0.52888986
161MP0005220_abnormal_exocrine_pancreas0.52326635
162MP0001663_abnormal_digestive_system0.52278474
163MP0009642_abnormal_blood_homeostasis0.52278046

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.14768331
2Deep venous thrombosis (HP:0002625)5.11448012
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.67545891
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.41822779
5Xanthomatosis (HP:0000991)4.25827221
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.25497036
7Abnormality of alanine metabolism (HP:0010916)4.25497036
8Hyperalaninemia (HP:0003348)4.25497036
9Complement deficiency (HP:0004431)4.16255302
10Hypobetalipoproteinemia (HP:0003563)3.98342405
11Hyperglycinuria (HP:0003108)3.93621730
12Malnutrition (HP:0004395)3.78821189
13Hyperammonemia (HP:0001987)3.72087312
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.59269844
15Male infertility (HP:0003251)3.52927580
16Acute necrotizing encephalopathy (HP:0006965)3.49078584
17Gout (HP:0001997)3.48263392
18Increased CSF lactate (HP:0002490)3.46140009
19Mitochondrial inheritance (HP:0001427)3.45283116
20Hyperglycinemia (HP:0002154)3.43328856
21Congenital, generalized hypertrichosis (HP:0004540)3.36596791
22Hepatocellular necrosis (HP:0001404)3.35472768
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.33219125
24Hypolipoproteinemia (HP:0010981)3.31502179
25Abnormality of complement system (HP:0005339)3.28193879
26Abnormality of serine family amino acid metabolism (HP:0010894)3.27510782
27Abnormality of glycine metabolism (HP:0010895)3.27510782
28Acute encephalopathy (HP:0006846)3.25233952
29Right ventricular cardiomyopathy (HP:0011663)3.22097912
30Systemic lupus erythematosus (HP:0002725)3.21598065
31Abnormal mitochondria in muscle tissue (HP:0008316)3.13957203
32Hepatic necrosis (HP:0002605)3.13510077
33Esophageal varix (HP:0002040)3.11990696
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.10303708
35Hypoplasia of the uterus (HP:0000013)3.07967249
36Hypoalphalipoproteinemia (HP:0003233)3.07554918
37Abnormality of purine metabolism (HP:0004352)3.03531022
38Hyperlipoproteinemia (HP:0010980)3.02746176
39Fat malabsorption (HP:0002630)3.00627779
40Abnormality of nucleobase metabolism (HP:0010932)2.97502494
41Pancreatic cysts (HP:0001737)2.92190689
42Aplasia/hypoplasia of the uterus (HP:0008684)2.89492002
43Prolonged partial thromboplastin time (HP:0003645)2.85978012
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.85545640
45Abnormality of fatty-acid metabolism (HP:0004359)2.85535799
46Abnormality of pyrimidine metabolism (HP:0004353)2.85445438
47Increased serum lactate (HP:0002151)2.84766427
48Progressive macrocephaly (HP:0004481)2.84005520
49Abnormality of midbrain morphology (HP:0002418)2.83296840
50Molar tooth sign on MRI (HP:0002419)2.83296840
51Ileus (HP:0002595)2.74169499
52Abnormality of the renal collecting system (HP:0004742)2.73974199
53Type I transferrin isoform profile (HP:0003642)2.72965262
54Ketosis (HP:0001946)2.69306230
55Duplicated collecting system (HP:0000081)2.68696789
56Lactic acidosis (HP:0003128)2.64902932
57Proximal tubulopathy (HP:0000114)2.64694762
58Glomerulonephritis (HP:0000099)2.63566863
59Joint hemorrhage (HP:0005261)2.62860744
60Increased purine levels (HP:0004368)2.62784620
61Hyperuricemia (HP:0002149)2.62784620
62Renal cortical cysts (HP:0000803)2.60527131
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57870732
64Abnormality of the common coagulation pathway (HP:0010990)2.56669389
65Breast hypoplasia (HP:0003187)2.56456660
66Concave nail (HP:0001598)2.55598976
67Abnormality of methionine metabolism (HP:0010901)2.54897991
68Congenital stationary night blindness (HP:0007642)2.51867407
69Epidermoid cyst (HP:0200040)2.51695910
70Abnormality of the intrinsic pathway (HP:0010989)2.50584819
71True hermaphroditism (HP:0010459)2.49818036
72Increased hepatocellular lipid droplets (HP:0006565)2.47367470
73Hypoglycemic coma (HP:0001325)2.46530626
74Cerebral edema (HP:0002181)2.45487363
75Myocardial infarction (HP:0001658)2.42713803
76Microretrognathia (HP:0000308)2.41373521
77Polycythemia (HP:0001901)2.40740752
78Methylmalonic acidemia (HP:0002912)2.36202652
79Pancreatic fibrosis (HP:0100732)2.34988583
80Abnormality of the renal cortex (HP:0011035)2.33995521
81Vascular calcification (HP:0004934)2.33180177
82Constricted visual fields (HP:0001133)2.31966402
83Lipid accumulation in hepatocytes (HP:0006561)2.30940267
84Spontaneous abortion (HP:0005268)2.30450048
85Abnormality of serum amino acid levels (HP:0003112)2.29625515
86Attenuation of retinal blood vessels (HP:0007843)2.29572181
87Lethargy (HP:0001254)2.29564612
88Methylmalonic aciduria (HP:0012120)2.28719699
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28398421
90Dicarboxylic aciduria (HP:0003215)2.28398421
91Hyperactive renin-angiotensin system (HP:0000841)2.27184510
92Abnormal protein glycosylation (HP:0012346)2.27133784
93Abnormal glycosylation (HP:0012345)2.27133784
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27133784
95Abnormal protein N-linked glycosylation (HP:0012347)2.27133784
96Premature ovarian failure (HP:0008209)2.22007187
97Pustule (HP:0200039)2.20249934
98Birth length less than 3rd percentile (HP:0003561)2.19997781
99Sparse eyelashes (HP:0000653)2.19777153
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.18459988
101Steatorrhea (HP:0002570)2.18083547
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17729950
103Large for gestational age (HP:0001520)2.16803196
104Shawl scrotum (HP:0000049)2.15998167
105Hepatocellular carcinoma (HP:0001402)2.15834551
106Renal Fanconi syndrome (HP:0001994)2.14292903
107Hypercholesterolemia (HP:0003124)2.12526145
108Amniotic constriction ring (HP:0009775)2.12259839
109Abnormality of placental membranes (HP:0011409)2.12259839
110Abnormal gallbladder physiology (HP:0012438)2.11229408
111Cholecystitis (HP:0001082)2.11229408
112Oral leukoplakia (HP:0002745)2.10328082
113Absent thumb (HP:0009777)2.08893320
114Congenital ichthyosiform erythroderma (HP:0007431)2.08503103
115Generalized aminoaciduria (HP:0002909)2.08407599
116Abnormality of DNA repair (HP:0003254)2.08372993
117Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07707409
118Sclerocornea (HP:0000647)2.07572481
119Nausea (HP:0002018)2.06809419
120Cortical dysplasia (HP:0002539)2.06242164
121Sensorimotor neuropathy (HP:0007141)2.05702220
122Abnormality of chloride homeostasis (HP:0011422)2.05495149
123Abnormal cartilage morphology (HP:0002763)2.04957796
124Abnormality of urine glucose concentration (HP:0011016)2.04488074
125Glycosuria (HP:0003076)2.04488074
126Metabolic acidosis (HP:0001942)2.03299507
127Ureteral duplication (HP:0000073)2.03240589
128Chromsome breakage (HP:0040012)2.02182384
129Adrenal hypoplasia (HP:0000835)2.01619986
130Dehydration (HP:0001944)2.00769915
131Neonatal death (HP:0003811)1.99360165
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.98835215
133Pendular nystagmus (HP:0012043)1.98383854
134Conjugated hyperbilirubinemia (HP:0002908)1.98312913
135Optic disc pallor (HP:0000543)1.97098439
136Cardiovascular calcification (HP:0011915)1.96971006
137Short tibia (HP:0005736)1.96405106
138Ketoacidosis (HP:0001993)1.96325512
139Brittle hair (HP:0002299)1.96298510
140Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95748441
141Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95748441
142Respiratory failure (HP:0002878)1.94885860
143Delayed CNS myelination (HP:0002188)1.94106837
144Nephronophthisis (HP:0000090)1.93949442
145Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93568001
146Woolly hair (HP:0002224)1.93042120
147Chorioretinal atrophy (HP:0000533)1.92218766
148Nephritis (HP:0000123)1.91786969
149Hyperglycemia (HP:0003074)1.91638705
150Late onset (HP:0003584)1.91186174
151Reduced antithrombin III activity (HP:0001976)1.91020644
152Secondary amenorrhea (HP:0000869)1.90987605
153Alopecia of scalp (HP:0002293)1.90927511
154Alkalosis (HP:0001948)1.89026816
155Reticulocytopenia (HP:0001896)1.88341190
156Increased serum pyruvate (HP:0003542)1.87858865
157Congenital sensorineural hearing impairment (HP:0008527)1.87558107
158Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87467881
159Acanthocytosis (HP:0001927)1.85424463
160Pancytopenia (HP:0001876)1.84402830
161Irritability (HP:0000737)1.84079379
162Aplastic anemia (HP:0001915)1.83262738
163Rickets (HP:0002748)1.83204931
1643-Methylglutaconic aciduria (HP:0003535)1.82946231
165Abnormality of the fetal cardiovascular system (HP:0010948)1.82729027
166Abnormal umbilical cord blood vessels (HP:0011403)1.82729027
167Single umbilical artery (HP:0001195)1.82729027
168Spastic diplegia (HP:0001264)1.82721717
169Pili torti (HP:0003777)1.81678580
170Rough bone trabeculation (HP:0100670)1.81401547
171Abnormality of the proximal phalanges of the hand (HP:0009834)1.79540800
172Abnormality of lateral ventricle (HP:0030047)1.79530763
173Aplasia/Hypoplasia of the tongue (HP:0010295)1.79207180
174Abnormality of macular pigmentation (HP:0008002)1.78799078
175Multiple enchondromatosis (HP:0005701)1.78793114
176Furrowed tongue (HP:0000221)1.77107333
177Autoimmune thrombocytopenia (HP:0001973)1.76456514
178CNS demyelination (HP:0007305)1.74474308
179Abnormality of proline metabolism (HP:0010907)1.74132470
180Hydroxyprolinuria (HP:0003080)1.74132470
181Disproportionate short-trunk short stature (HP:0003521)1.73947313
182Pancreatitis (HP:0001733)1.72023305
183Neutropenia (HP:0001875)1.71031755
184Hypergonadotropic hypogonadism (HP:0000815)1.69014711
185Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67980999
186Abnormality of renal resorption (HP:0011038)1.67832194
187Severe muscular hypotonia (HP:0006829)1.67346971
188Abnormal biliary tract morphology (HP:0012440)1.66843554
189Hemorrhage of the eye (HP:0011885)1.63761313
190Hyperbilirubinemia (HP:0002904)1.62239280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.76859814
2STK38L3.55687665
3LATS23.23832018
4TAOK33.02503897
5EPHA22.91962380
6MAP4K22.90426136
7MAP3K62.89780284
8VRK22.83519485
9ERBB42.77669378
10BCKDK2.36474614
11KSR22.29650337
12ERN12.28404420
13TTK2.23782421
14TESK22.22982641
15MST1R2.21818913
16GRK12.16191185
17MAPKAPK32.01445564
18PLK41.93371612
19TLK11.93079150
20BMPR1B1.91408818
21WNK41.88514834
22LIMK11.82397506
23TRIM281.79796705
24ADRBK21.79457676
25TAOK11.77402859
26TRIB31.77226165
27EEF2K1.76538023
28MAP3K121.73961662
29STK101.72350696
30ZAK1.71906835
31STK31.66694788
32STK161.65772276
33MOS1.62865289
34TESK11.55773482
35STK391.54767054
36RPS6KB21.48124581
37TXK1.46609209
38PKN21.46275676
39TIE11.44300576
40PBK1.36286344
41EIF2AK31.36036838
42NEK21.35101882
43BRAF1.34982182
44OXSR11.27439479
45ABL21.26981778
46MYLK1.24794194
47MAP3K81.21104792
48FRK1.19910543
49MAP3K31.19337872
50FLT31.17989655
51MELK1.16445783
52NEK11.16160209
53MAP2K21.12580510
54VRK11.11590461
55FGFR41.10622886
56MAP3K91.10091294
57ARAF1.07186667
58ADRBK11.06271194
59RAF11.06027514
60PTK2B1.04539216
61CDK81.04015801
62NME11.01875558
63MAPK110.99529098
64KDR0.99467754
65BUB10.98229017
66CDK90.97766998
67PHKG10.95675680
68PHKG20.95675680
69MAP3K110.94894262
70TYK20.91507796
71LRRK20.91315821
72MST40.91284023
73INSRR0.91034916
74TGFBR20.88187538
75SRPK10.87197697
76PAK40.86014170
77AURKB0.85828275
78WNK30.85567024
79MET0.85475724
80STK380.85461409
81CDK120.84781139
82CHEK20.84525899
83PTK60.84313600
84NEK90.84267802
85RIPK10.84030494
86BCR0.81450025
87PLK30.77890328
88PRKAA20.77442368
89MAP2K70.77295930
90PIM20.77055767
91PLK10.76842730
92PRKCE0.74709647
93MAP3K130.74109522
94PRKCI0.72506672
95RPS6KA40.70331074
96SIK30.70053224
97ILK0.70033260
98CDC70.69538517
99LMTK20.68674611
100CDK70.67568692
101ACVR1B0.67036285
102EPHB20.66828888
103CDK40.65931926
104PDK20.65324069
105WEE10.64943810
106PLK20.64858074
107DYRK20.63442136
108MAP2K60.63269029
109MUSK0.63182915
110EIF2AK10.61146082
111BMPR20.60953498
112DAPK10.60090012
113PRKG20.59610119
114CDK60.58481620
115PRKAA10.57830763
116CCNB10.56957759
117MAP2K10.54851411
118PTK20.53652737
119IKBKB0.53187950
120CSNK1G30.52121916
121MAP2K30.51452207
122CSNK1G10.51104819
123MAP3K10.50388034
124JAK20.47740977
125FER0.47591219
126TGFBR10.45425669
127PIK3CA0.44865016
128IRAK30.44534058
129CSNK1A1L0.43645682
130CDK190.43629370
131AURKA0.43200625
132PIM10.43084682
133STK240.43013265
134NLK0.42860050
135MAP3K50.42709023
136CSNK1A10.42399617
137ERBB20.41760540
138CAMK2D0.41514129
139EIF2AK20.41443814
140MAPK130.40404447
141DYRK30.40067138
142MAP3K20.39983888
143NME20.38721141
144CSNK2A10.36122621
145ERBB30.36117706
146GRK60.35570585
147PRKD20.35246904
148TEC0.34089947
149MATK0.33077860
150MAP4K10.32617290
151NUAK10.31274053
152AKT30.30959168
153ABL10.30479647
154PINK10.29803963
155SIK10.29676566

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.90581687
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42838580
3Oxidative phosphorylation_Homo sapiens_hsa001903.12929271
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.05650869
5Arginine biosynthesis_Homo sapiens_hsa002202.55321593
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47719741
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44104874
8Nitrogen metabolism_Homo sapiens_hsa009102.32787226
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30277717
10Tryptophan metabolism_Homo sapiens_hsa003802.25384090
11Parkinsons disease_Homo sapiens_hsa050122.24369102
12Protein export_Homo sapiens_hsa030602.21633404
13Fatty acid degradation_Homo sapiens_hsa000712.17120130
14Complement and coagulation cascades_Homo sapiens_hsa046102.16035955
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15703979
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15336239
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13923777
18Folate biosynthesis_Homo sapiens_hsa007902.08760050
19Histidine metabolism_Homo sapiens_hsa003401.91826630
20Ribosome_Homo sapiens_hsa030101.88335231
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83843140
22Staphylococcus aureus infection_Homo sapiens_hsa051501.83463878
23Fat digestion and absorption_Homo sapiens_hsa049751.79261241
24Caffeine metabolism_Homo sapiens_hsa002321.75843703
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71777362
26Vitamin B6 metabolism_Homo sapiens_hsa007501.71585349
27Peroxisome_Homo sapiens_hsa041461.70730245
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.70130278
29Huntingtons disease_Homo sapiens_hsa050161.68092425
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67441346
31beta-Alanine metabolism_Homo sapiens_hsa004101.66359986
32Propanoate metabolism_Homo sapiens_hsa006401.63307978
33Chemical carcinogenesis_Homo sapiens_hsa052041.59133365
34PPAR signaling pathway_Homo sapiens_hsa033201.58018388
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56780867
36Alzheimers disease_Homo sapiens_hsa050101.54171720
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53646096
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.48703642
39Butanoate metabolism_Homo sapiens_hsa006501.47318151
40Vitamin digestion and absorption_Homo sapiens_hsa049771.46362324
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.45516989
42Nucleotide excision repair_Homo sapiens_hsa034201.44538325
43Retinol metabolism_Homo sapiens_hsa008301.43619162
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43172810
45Selenocompound metabolism_Homo sapiens_hsa004501.43065377
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42347883
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39164134
48Collecting duct acid secretion_Homo sapiens_hsa049661.37021069
49Linoleic acid metabolism_Homo sapiens_hsa005911.34968342
50Glutathione metabolism_Homo sapiens_hsa004801.34816134
51Mismatch repair_Homo sapiens_hsa034301.33115955
52Fatty acid metabolism_Homo sapiens_hsa012121.30458577
53Biosynthesis of amino acids_Homo sapiens_hsa012301.30309919
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27618015
55Fanconi anemia pathway_Homo sapiens_hsa034601.26345492
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25686027
57Arginine and proline metabolism_Homo sapiens_hsa003301.25244523
58Bile secretion_Homo sapiens_hsa049761.24570706
59Pentose phosphate pathway_Homo sapiens_hsa000301.20532060
60Pyruvate metabolism_Homo sapiens_hsa006201.19666740
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.16834362
62Carbon metabolism_Homo sapiens_hsa012001.16518543
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14125219
64Phototransduction_Homo sapiens_hsa047441.11219588
65DNA replication_Homo sapiens_hsa030301.10080324
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09397286
67Sulfur metabolism_Homo sapiens_hsa009201.08332906
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07574304
69Purine metabolism_Homo sapiens_hsa002301.05293912
70Phenylalanine metabolism_Homo sapiens_hsa003600.99310245
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98452972
72Starch and sucrose metabolism_Homo sapiens_hsa005000.95960275
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91962027
74Sulfur relay system_Homo sapiens_hsa041220.91456867
75One carbon pool by folate_Homo sapiens_hsa006700.90288852
76Other glycan degradation_Homo sapiens_hsa005110.89057832
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88170230
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83613564
79Glycerolipid metabolism_Homo sapiens_hsa005610.81696070
80Tyrosine metabolism_Homo sapiens_hsa003500.81265123
81Lysine degradation_Homo sapiens_hsa003100.79753433
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79333051
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79024681
84Arachidonic acid metabolism_Homo sapiens_hsa005900.77288435
85N-Glycan biosynthesis_Homo sapiens_hsa005100.75307873
86Fructose and mannose metabolism_Homo sapiens_hsa000510.74931725
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.74799214
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72346054
89Non-homologous end-joining_Homo sapiens_hsa034500.71800953
90Cell cycle_Homo sapiens_hsa041100.71063723
91Cardiac muscle contraction_Homo sapiens_hsa042600.68564372
92ABC transporters_Homo sapiens_hsa020100.68408849
93Mineral absorption_Homo sapiens_hsa049780.65501823
94Galactose metabolism_Homo sapiens_hsa000520.63276372
95Regulation of autophagy_Homo sapiens_hsa041400.60637770
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60575812
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.60464163
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59544519
99Ovarian steroidogenesis_Homo sapiens_hsa049130.55870271
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54867470
101Spliceosome_Homo sapiens_hsa030400.52890307
102Fatty acid elongation_Homo sapiens_hsa000620.52425908
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50008115
104RNA degradation_Homo sapiens_hsa030180.49599230
105Bladder cancer_Homo sapiens_hsa052190.49475231
106RNA polymerase_Homo sapiens_hsa030200.48976956
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48633698
108Steroid biosynthesis_Homo sapiens_hsa001000.48097005
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47904796
110Metabolic pathways_Homo sapiens_hsa011000.47026797
111p53 signaling pathway_Homo sapiens_hsa041150.46816429
112Ether lipid metabolism_Homo sapiens_hsa005650.45094531
113Adherens junction_Homo sapiens_hsa045200.44602181
114TGF-beta signaling pathway_Homo sapiens_hsa043500.41706042
115Vibrio cholerae infection_Homo sapiens_hsa051100.41521964
116Pyrimidine metabolism_Homo sapiens_hsa002400.38663618
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37612001
118Sphingolipid metabolism_Homo sapiens_hsa006000.37568685
119Pancreatic cancer_Homo sapiens_hsa052120.34384755
120Renin-angiotensin system_Homo sapiens_hsa046140.32860447
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32248608
122Olfactory transduction_Homo sapiens_hsa047400.30373812
123Basal transcription factors_Homo sapiens_hsa030220.30121583
124Base excision repair_Homo sapiens_hsa034100.28496010
125Circadian rhythm_Homo sapiens_hsa047100.28393885
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.25242506
127RNA transport_Homo sapiens_hsa030130.25160488
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23683202
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23026081
130Thyroid cancer_Homo sapiens_hsa052160.22733084
131Tight junction_Homo sapiens_hsa045300.22090905
132Small cell lung cancer_Homo sapiens_hsa052220.21635603
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20919457
134Homologous recombination_Homo sapiens_hsa034400.16516782
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.15980280

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