SMAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.45375936
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13902963
3neuron cell-cell adhesion (GO:0007158)5.04923966
4synaptic vesicle maturation (GO:0016188)4.84060429
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83257322
6regulation of synaptic vesicle exocytosis (GO:2000300)4.81439229
7glutamate secretion (GO:0014047)4.78108389
8protein localization to synapse (GO:0035418)4.75524040
9synaptic vesicle exocytosis (GO:0016079)4.60130987
10locomotory exploration behavior (GO:0035641)4.53468218
11positive regulation of mitochondrial fission (GO:0090141)4.43802037
12nucleobase catabolic process (GO:0046113)4.43751558
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35385480
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24309478
15exploration behavior (GO:0035640)4.15312833
16neuron recognition (GO:0008038)4.12314911
17layer formation in cerebral cortex (GO:0021819)4.10474533
18vocalization behavior (GO:0071625)4.10159064
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.03922148
20axonal fasciculation (GO:0007413)4.03590760
21proline transport (GO:0015824)3.98353640
22regulation of synaptic vesicle transport (GO:1902803)3.93689968
23protein-cofactor linkage (GO:0018065)3.92209752
24response to methylmercury (GO:0051597)3.87575744
25regulation of glutamate receptor signaling pathway (GO:1900449)3.79380908
26protein neddylation (GO:0045116)3.77019469
27positive regulation of monocyte chemotaxis (GO:0090026)3.72885423
28dendritic spine morphogenesis (GO:0060997)3.62883679
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59510282
30negative regulation of heart rate (GO:0010459)3.56552030
31glutamate receptor signaling pathway (GO:0007215)3.54355890
32positive regulation of action potential (GO:0045760)3.53697962
33negative regulation of microtubule polymerization (GO:0031115)3.49100701
34DNA double-strand break processing (GO:0000729)3.43475675
35clathrin coat assembly (GO:0048268)3.43099487
36negative regulation of cell killing (GO:0031342)3.40990552
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40990552
38establishment of mitochondrion localization (GO:0051654)3.32999121
39regulation of neuronal synaptic plasticity (GO:0048168)3.32688828
40neuronal action potential propagation (GO:0019227)3.30662913
41nonmotile primary cilium assembly (GO:0035058)3.30562791
42presynaptic membrane assembly (GO:0097105)3.28433018
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.28217782
44calcium ion-dependent exocytosis (GO:0017156)3.26347239
45protein localization to cilium (GO:0061512)3.24758735
46gamma-aminobutyric acid transport (GO:0015812)3.23951267
47acrosome assembly (GO:0001675)3.20953777
48DNA damage response, detection of DNA damage (GO:0042769)3.20619540
49postsynaptic membrane organization (GO:0001941)3.19817527
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18462887
51neurotransmitter secretion (GO:0007269)3.18390971
52acrosome reaction (GO:0007340)3.17914784
53regulation of action potential (GO:0098900)3.16998930
54mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16519504
55synaptic vesicle docking involved in exocytosis (GO:0016081)3.13526952
56cellular potassium ion homeostasis (GO:0030007)3.13466799
57synaptic transmission, glutamatergic (GO:0035249)3.13025616
58neuron-neuron synaptic transmission (GO:0007270)3.09204009
59establishment of melanosome localization (GO:0032401)3.07721023
60limb bud formation (GO:0060174)3.05645437
61positive regulation of membrane potential (GO:0045838)3.00794869
62sperm motility (GO:0030317)2.99590292
63regulation of neurotransmitter secretion (GO:0046928)2.98244369
64long-term memory (GO:0007616)2.96933124
65response to histamine (GO:0034776)2.96667683
66dendrite morphogenesis (GO:0048813)2.95662545
67short-term memory (GO:0007614)2.95586752
68mating behavior (GO:0007617)2.94049869
69negative regulation of neurotransmitter transport (GO:0051589)2.93975606
70vesicle transport along microtubule (GO:0047496)2.92916615
71regulation of synapse structural plasticity (GO:0051823)2.92687391
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92196517
73spermatid nucleus differentiation (GO:0007289)2.90982043
74organelle disassembly (GO:1903008)2.90534017
75establishment of pigment granule localization (GO:0051905)2.90177788
76melanosome transport (GO:0032402)2.88599553
77long-term synaptic potentiation (GO:0060291)2.88273276
78organelle transport along microtubule (GO:0072384)2.88120528
79neural tube formation (GO:0001841)2.86945608
80regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.86270600
81intraciliary transport (GO:0042073)2.84744399
82positive regulation of synapse maturation (GO:0090129)2.84143004
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83309380
84positive regulation of neurotransmitter secretion (GO:0001956)2.81664925
85sodium ion export (GO:0071436)2.80464951
86auditory behavior (GO:0031223)2.80189366
87tachykinin receptor signaling pathway (GO:0007217)2.79433709
88regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78426283
89regulation of vesicle fusion (GO:0031338)2.76861956
90regulation of cAMP-dependent protein kinase activity (GO:2000479)2.76698854
91regulation of synaptic plasticity (GO:0048167)2.76448832
92positive regulation of synaptic transmission, GABAergic (GO:0032230)2.76146028
93central nervous system projection neuron axonogenesis (GO:0021952)2.75660034
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75484527
95transmission of nerve impulse (GO:0019226)2.75312469
96C4-dicarboxylate transport (GO:0015740)2.74428294
97cerebral cortex radially oriented cell migration (GO:0021799)2.74146502
98neuron fate determination (GO:0048664)2.73893458
99regulation of filopodium assembly (GO:0051489)2.73767281
100presynaptic membrane organization (GO:0097090)2.72587153
101positive regulation of fibroblast migration (GO:0010763)2.71539691
102retinal cone cell development (GO:0046549)2.71512242
103pigment granule transport (GO:0051904)2.71128056
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69332784
105respiratory electron transport chain (GO:0022904)2.68700205
106regulation of mitochondrial fission (GO:0090140)2.68274485
107neurotransmitter transport (GO:0006836)2.68066292
108positive regulation of filopodium assembly (GO:0051491)2.67685495
109ATP synthesis coupled proton transport (GO:0015986)2.66953299
110energy coupled proton transport, down electrochemical gradient (GO:0015985)2.66953299
111glycine transport (GO:0015816)2.66308799
112regulation of dendritic spine morphogenesis (GO:0061001)2.65219406
113electron transport chain (GO:0022900)2.62192371
114retinal ganglion cell axon guidance (GO:0031290)2.62001169
115regulation of postsynaptic membrane potential (GO:0060078)2.61776857
116melanosome localization (GO:0032400)2.61489644
117mitochondrion transport along microtubule (GO:0047497)2.61297887
118establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.61297887
119positive regulation of synapse assembly (GO:0051965)2.60743116
120protein complex biogenesis (GO:0070271)2.60739222
121negative regulation of inclusion body assembly (GO:0090084)2.59812493
122regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59192630
123energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59125591
124ATP hydrolysis coupled proton transport (GO:0015991)2.59125591
125substrate-independent telencephalic tangential migration (GO:0021826)2.58900780
126substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.58900780
127negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.58292728
128activation of protein kinase A activity (GO:0034199)2.57990165
129protoporphyrinogen IX metabolic process (GO:0046501)2.57138230
130synaptic vesicle endocytosis (GO:0048488)2.56797912
131behavioral response to nicotine (GO:0035095)2.55754078
132apical protein localization (GO:0045176)2.54764277
133regulation of development, heterochronic (GO:0040034)2.53734751
134positive regulation of neurotransmitter transport (GO:0051590)2.53263137
135regulation of neurotransmitter transport (GO:0051588)2.53184035
136positive regulation of dendritic spine morphogenesis (GO:0061003)2.53173827
137long-chain fatty acid biosynthetic process (GO:0042759)2.53115355
138startle response (GO:0001964)2.53032712
139ribonucleoprotein complex disassembly (GO:0032988)2.51800843
140regulation of feeding behavior (GO:0060259)2.51502028
141regulation of hydrogen peroxide metabolic process (GO:0010310)2.51409586
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51171261
143positive regulation of dendritic spine development (GO:0060999)2.49864673
144membrane hyperpolarization (GO:0060081)2.49347647
145regulation of monocyte chemotaxis (GO:0090025)2.49309580
146learning (GO:0007612)2.49119738
147neurotransmitter-gated ion channel clustering (GO:0072578)2.48223179
148regulation of dendritic spine development (GO:0060998)2.47784140
149glycosphingolipid biosynthetic process (GO:0006688)2.47748233
150synapse assembly (GO:0007416)2.47705605
151neurofilament cytoskeleton organization (GO:0060052)2.47622041
152pigment granule localization (GO:0051875)2.47199122
153microtubule depolymerization (GO:0007019)2.46740968
154establishment of protein localization to mitochondrial membrane (GO:0090151)2.46462368
155atrial cardiac muscle cell action potential (GO:0086014)2.44832637
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.43757777
157regulation of mitotic spindle checkpoint (GO:1903504)2.43757777
158mechanosensory behavior (GO:0007638)2.43463336
159histone H2A acetylation (GO:0043968)2.42663355
160negative regulation of membrane potential (GO:0045837)2.40657939
161regulation of timing of cell differentiation (GO:0048505)2.39436985
162response to auditory stimulus (GO:0010996)2.38872070
163chaperone-mediated protein transport (GO:0072321)2.38077864
164G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37831248
165anterograde axon cargo transport (GO:0008089)2.37813641
166cullin deneddylation (GO:0010388)2.37765452
167establishment of vesicle localization (GO:0051650)2.37529185
168mitochondrial respiratory chain complex assembly (GO:0033108)2.37425928
169vesicle localization (GO:0051648)2.37321549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89838358
2GBX2_23144817_ChIP-Seq_PC3_Human3.17198858
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.94461815
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74110295
5REST_21632747_ChIP-Seq_MESCs_Mouse2.63444280
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62379631
7ZNF274_21170338_ChIP-Seq_K562_Hela2.37274105
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35035112
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22632427
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20686471
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18623631
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18503855
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18331012
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16243476
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16243476
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15811334
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11506342
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10204165
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09348639
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.09236832
21TAF15_26573619_Chip-Seq_HEK293_Human2.05842045
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.04237694
23FUS_26573619_Chip-Seq_HEK293_Human1.96556660
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95883539
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.95806484
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.93492569
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93256315
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92702783
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92428075
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90997160
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87865497
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.87021541
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83044325
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81922914
35AR_21572438_ChIP-Seq_LNCaP_Human1.80094868
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79549180
37* FLI1_27457419_Chip-Seq_LIVER_Mouse1.76342324
38VDR_22108803_ChIP-Seq_LS180_Human1.73466329
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.73295315
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.72459619
41* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.72198550
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.71686258
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.67910280
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67756530
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.67245462
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.60769015
47P300_19829295_ChIP-Seq_ESCs_Human1.59718471
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56290518
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54260116
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.53575227
51DROSHA_22980978_ChIP-Seq_HELA_Human1.52994309
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51596076
53ELK1_19687146_ChIP-ChIP_HELA_Human1.47304400
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45718545
55SMAD4_21799915_ChIP-Seq_A2780_Human1.43966124
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.43313367
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42581444
58* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42419720
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41336897
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40421499
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38619236
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38528859
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38499749
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37734236
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37188123
66AR_25329375_ChIP-Seq_VCAP_Human1.37183871
67ER_23166858_ChIP-Seq_MCF-7_Human1.34896420
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32259665
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32085505
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30675346
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29861919
72RNF2_27304074_Chip-Seq_NSC_Mouse1.25655689
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.24636064
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23265335
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.22582028
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21581791
77JUN_21703547_ChIP-Seq_K562_Human1.21575657
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21310094
79* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20758169
80ZNF263_19887448_ChIP-Seq_K562_Human1.20750112
81* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20527693
82IGF1R_20145208_ChIP-Seq_DFB_Human1.20472514
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20461968
84KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19743714
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19582984
86MYC_18940864_ChIP-ChIP_HL60_Human1.19246166
87* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19081787
88* EZH2_27294783_Chip-Seq_NPCs_Mouse1.18265482
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.16950467
90* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16672443
91BCAT_22108803_ChIP-Seq_LS180_Human1.15827940
92* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15673988
93* RUNX2_22187159_ChIP-Seq_PCA_Human1.15611794
94STAT3_23295773_ChIP-Seq_U87_Human1.15601561
95* SMAD3_21741376_ChIP-Seq_ESCs_Human1.14119713
96* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12648992
97* P53_22387025_ChIP-Seq_ESCs_Mouse1.12648462
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11177830
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11107658
100TP53_22573176_ChIP-Seq_HFKS_Human1.10587582
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10182485
102TP53_18474530_ChIP-ChIP_U2OS_Human1.10062022
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08760185
104CBP_20019798_ChIP-Seq_JUKART_Human1.08760185
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08542451
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07422307
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06868797
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05671576
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05311476
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.05246216
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04813126
112TCF4_22108803_ChIP-Seq_LS180_Human1.04571305
113VDR_24787735_ChIP-Seq_THP-1_Human1.04268914
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03459870
115* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02758878
116TCF4_23295773_ChIP-Seq_U87_Human1.02728745
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02422838
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02297181
119NANOG_19829295_ChIP-Seq_ESCs_Human1.01274669
120SOX2_19829295_ChIP-Seq_ESCs_Human1.01274669
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.01270776
122* NFE2_27457419_Chip-Seq_LIVER_Mouse1.00779993
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.99336190
124* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99093741
125* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98683475
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97987872
127* CMYC_18555785_Chip-Seq_ESCs_Mouse0.97812869
128TP53_16413492_ChIP-PET_HCT116_Human0.97479957
129* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96821820
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96797839
131* NANOG_18555785_Chip-Seq_ESCs_Mouse0.96623649
132TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96280749
133* CRX_20693478_ChIP-Seq_RETINA_Mouse0.95058180
134GATA1_26923725_Chip-Seq_HPCs_Mouse0.94842332
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94554023
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.92383081
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92297750
138* RING1B_27294783_Chip-Seq_NPCs_Mouse0.92218159
139KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92169316
140AHR_22903824_ChIP-Seq_MCF-7_Human0.91845609
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.89459480
142SOX9_26525672_Chip-Seq_HEART_Mouse0.89283893
143EWS_26573619_Chip-Seq_HEK293_Human0.87398124
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86989400

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49696039
2MP0003880_abnormal_central_pattern5.20772887
3MP0003635_abnormal_synaptic_transmissio3.64984196
4MP0004270_analgesia3.35060279
5MP0005410_abnormal_fertilization3.32272183
6MP0001968_abnormal_touch/_nociception3.00072636
7MP0002063_abnormal_learning/memory/cond2.93522935
8MP0002102_abnormal_ear_morphology2.82802297
9MP0009046_muscle_twitch2.71163658
10MP0002064_seizures2.68314124
11MP0009745_abnormal_behavioral_response2.67856826
12MP0003329_amyloid_beta_deposits2.59065034
13MP0003121_genomic_imprinting2.58735991
14MP0002734_abnormal_mechanical_nocicepti2.47932486
15MP0002736_abnormal_nociception_after2.42413217
16MP0002572_abnormal_emotion/affect_behav2.36493677
17MP0005423_abnormal_somatic_nervous2.35332425
18MP0002735_abnormal_chemical_nociception2.29015424
19MP0000569_abnormal_digit_pigmentation2.27866837
20MP0001486_abnormal_startle_reflex2.22851317
21MP0000778_abnormal_nervous_system2.17431169
22MP0002733_abnormal_thermal_nociception2.11543685
23MP0001440_abnormal_grooming_behavior2.08963604
24MP0006276_abnormal_autonomic_nervous2.04536766
25MP0001501_abnormal_sleep_pattern1.93251831
26MP0004885_abnormal_endolymph1.92606713
27MP0004811_abnormal_neuron_physiology1.88340422
28MP0002272_abnormal_nervous_system1.80419183
29MP0001970_abnormal_pain_threshold1.79055250
30MP0002067_abnormal_sensory_capabilities1.73762583
31MP0005623_abnormal_meninges_morphology1.72024785
32MP0010386_abnormal_urinary_bladder1.71552079
33MP0002184_abnormal_innervation1.69566781
34MP0005386_behavior/neurological_phenoty1.69368183
35MP0004924_abnormal_behavior1.69368183
36MP0002638_abnormal_pupillary_reflex1.66086110
37MP0002837_dystrophic_cardiac_calcinosis1.62432209
38MP0002557_abnormal_social/conspecific_i1.61785263
39MP0009780_abnormal_chondrocyte_physiolo1.61146195
40MP0000604_amyloidosis1.58168323
41MP0006292_abnormal_olfactory_placode1.54213367
42MP0003656_abnormal_erythrocyte_physiolo1.51235230
43MP0001984_abnormal_olfaction1.50470826
44MP0008569_lethality_at_weaning1.44839661
45MP0004858_abnormal_nervous_system1.42977812
46MP0004147_increased_porphyrin_level1.41284958
47MP0000955_abnormal_spinal_cord1.40805469
48MP0002882_abnormal_neuron_morphology1.40054470
49MP0003011_delayed_dark_adaptation1.37499254
50MP0000516_abnormal_urinary_system1.34409883
51MP0005367_renal/urinary_system_phenotyp1.34409883
52MP0001529_abnormal_vocalization1.32085561
53MP0001905_abnormal_dopamine_level1.32080248
54MP0003698_abnormal_male_reproductive1.31044810
55MP0003567_abnormal_fetal_cardiomyocyte1.30942601
56MP0000049_abnormal_middle_ear1.30814449
57MP0002751_abnormal_autonomic_nervous1.30110002
58MP0002066_abnormal_motor_capabilities/c1.29045546
59MP0005084_abnormal_gallbladder_morpholo1.27505444
60MP0002152_abnormal_brain_morphology1.22394194
61MP0002234_abnormal_pharynx_morphology1.19731115
62MP0001348_abnormal_lacrimal_gland1.17004425
63MP0000920_abnormal_myelination1.15721651
64MP0005187_abnormal_penis_morphology1.15675816
65MP0010234_abnormal_vibrissa_follicle1.14844227
66MP0004742_abnormal_vestibular_system1.10757998
67MP0004133_heterotaxia1.10180539
68MP0003122_maternal_imprinting1.09080796
69MP0003787_abnormal_imprinting1.07707214
70MP0003634_abnormal_glial_cell1.05295601
71MP0002822_catalepsy1.03457312
72MP0003283_abnormal_digestive_organ1.03192048
73MP0006072_abnormal_retinal_apoptosis1.02175417
74MP0008995_early_reproductive_senescence1.01575682
75MP0005253_abnormal_eye_physiology0.99971289
76MP0003119_abnormal_digestive_system0.99948797
77MP0008872_abnormal_physiological_respon0.99796650
78MP0003631_nervous_system_phenotype0.99758319
79MP0005499_abnormal_olfactory_system0.99535362
80MP0005394_taste/olfaction_phenotype0.99535362
81MP0003937_abnormal_limbs/digits/tail_de0.98353457
82MP0003633_abnormal_nervous_system0.97144018
83MP0004142_abnormal_muscle_tone0.96436593
84MP0000647_abnormal_sebaceous_gland0.95750905
85MP0001188_hyperpigmentation0.95387891
86MP0006035_abnormal_mitochondrial_morpho0.94254370
87MP0001963_abnormal_hearing_physiology0.92219343
88MP0002090_abnormal_vision0.92035688
89MP0008877_abnormal_DNA_methylation0.90092977
90MP0002233_abnormal_nose_morphology0.89714068
91MP0001177_atelectasis0.88985294
92MP0004215_abnormal_myocardial_fiber0.88486795
93MP0002229_neurodegeneration0.86925024
94MP0000566_synostosis0.86312156
95MP0003632_abnormal_nervous_system0.85322461
96MP0005646_abnormal_pituitary_gland0.83652557
97MP0003861_abnormal_nervous_system0.82486359
98MP0001929_abnormal_gametogenesis0.81820544
99MP0005248_abnormal_Harderian_gland0.79438552
100MP0002909_abnormal_adrenal_gland0.79026549
101MP0000427_abnormal_hair_cycle0.75901829
102MP0008789_abnormal_olfactory_epithelium0.75011196
103MP0002277_abnormal_respiratory_mucosa0.74971307
104MP0002938_white_spotting0.74646999
105MP0003221_abnormal_cardiomyocyte_apopto0.74298642
106MP0002161_abnormal_fertility/fecundity0.73392706
107MP0003879_abnormal_hair_cell0.72964263
108MP0002653_abnormal_ependyma_morphology0.70181588
109MP0002069_abnormal_eating/drinking_beha0.67798621
110MP0002752_abnormal_somatic_nervous0.67633751
111MP0001502_abnormal_circadian_rhythm0.65572169
112MP0003303_peritoneal_inflammation0.63991076
113MP0005310_abnormal_salivary_gland0.61715965
114MP0000343_altered_response_to0.59533290
115MP0005166_decreased_susceptibility_to0.58368123
116MP0000631_abnormal_neuroendocrine_gland0.58127188
117MP0001485_abnormal_pinna_reflex0.57718340
118MP0001299_abnormal_eye_distance/0.57169949
119MP0003890_abnormal_embryonic-extraembry0.55617432
120MP0001664_abnormal_digestion0.52250700
121MP0000026_abnormal_inner_ear0.51296392
122MP0003075_altered_response_to0.50313312
123MP0005645_abnormal_hypothalamus_physiol0.50273415
124MP0005174_abnormal_tail_pigmentation0.49739481
125MP0010770_preweaning_lethality0.49470096
126MP0002082_postnatal_lethality0.49470096
127MP0010769_abnormal_survival0.49074647
128MP0005535_abnormal_body_temperature0.49067297
129MP0005551_abnormal_eye_electrophysiolog0.48817503
130MP0004484_altered_response_of0.48632258
131MP0003690_abnormal_glial_cell0.47983791
132MP0003123_paternal_imprinting0.47983756
133MP0003938_abnormal_ear_development0.47707392

Predicted human phenotypes

RankGene SetZ-score
1Cerebral inclusion bodies (HP:0100314)4.39570765
2Focal motor seizures (HP:0011153)4.36263928
3Epileptic encephalopathy (HP:0200134)4.35398722
4Neurofibrillary tangles (HP:0002185)4.31184514
5Myokymia (HP:0002411)4.30833837
6Mutism (HP:0002300)4.03843985
7Focal seizures (HP:0007359)4.00270127
8Supranuclear gaze palsy (HP:0000605)3.94535535
9Limb dystonia (HP:0002451)3.81144057
10Absent/shortened dynein arms (HP:0200106)3.76372132
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.76372132
12Atonic seizures (HP:0010819)3.67861176
13Visual hallucinations (HP:0002367)3.65513754
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.59214905
15Disinhibition (HP:0000734)3.46544092
16Diplopia (HP:0000651)3.35375818
17Abnormality of binocular vision (HP:0011514)3.35375818
18Progressive cerebellar ataxia (HP:0002073)3.32796099
19Papilledema (HP:0001085)3.29923808
20Medial flaring of the eyebrow (HP:0010747)3.26101787
21Apathy (HP:0000741)3.25978551
22Inappropriate behavior (HP:0000719)3.23279099
23Abnormality of the labia minora (HP:0012880)3.18711921
24Truncal ataxia (HP:0002078)3.18334031
25Congenital primary aphakia (HP:0007707)3.17207648
26Ankle clonus (HP:0011448)3.14786876
27Acute necrotizing encephalopathy (HP:0006965)3.10966536
28Nephrogenic diabetes insipidus (HP:0009806)3.10794146
29Termporal pattern (HP:0011008)3.06147662
30Insidious onset (HP:0003587)3.06147662
31Action tremor (HP:0002345)3.05773984
32Amyotrophic lateral sclerosis (HP:0007354)2.95941869
33Absence seizures (HP:0002121)2.95514856
34Progressive inability to walk (HP:0002505)2.94889646
35Generalized tonic-clonic seizures (HP:0002069)2.87426452
36Genital tract atresia (HP:0001827)2.86885728
37Aplasia cutis congenita (HP:0001057)2.81184952
38Vaginal atresia (HP:0000148)2.80514996
39Progressive macrocephaly (HP:0004481)2.79679175
40Polyphagia (HP:0002591)2.78896669
41Diminished motivation (HP:0000745)2.78722427
42Genetic anticipation (HP:0003743)2.75749861
43Delusions (HP:0000746)2.75438839
44Methylmalonic acidemia (HP:0002912)2.73101942
45Abnormality of the corticospinal tract (HP:0002492)2.72609529
46Abnormal mitochondria in muscle tissue (HP:0008316)2.71259372
47Broad-based gait (HP:0002136)2.65640340
48Febrile seizures (HP:0002373)2.64309107
49Acute encephalopathy (HP:0006846)2.60901062
50Abnormal respiratory epithelium morphology (HP:0012253)2.57685357
51Abnormal respiratory motile cilium morphology (HP:0005938)2.57685357
52Intestinal atresia (HP:0011100)2.56035098
53Mitochondrial inheritance (HP:0001427)2.55975709
54Dialeptic seizures (HP:0011146)2.55701682
55Abnormal respiratory motile cilium physiology (HP:0012261)2.54791357
56Volvulus (HP:0002580)2.47542129
57Abnormal hair whorl (HP:0010721)2.47435263
58Lissencephaly (HP:0001339)2.47092754
59Akinesia (HP:0002304)2.45466822
60Excessive salivation (HP:0003781)2.42993617
61Drooling (HP:0002307)2.42993617
62Hemiparesis (HP:0001269)2.42476314
63Poor eye contact (HP:0000817)2.41777372
64Increased CSF lactate (HP:0002490)2.41626145
65Depression (HP:0000716)2.40972753
66Poor suck (HP:0002033)2.39561000
67Hyperglycinemia (HP:0002154)2.35449776
68Abnormal eating behavior (HP:0100738)2.34788990
69Absent speech (HP:0001344)2.33568653
70Increased hepatocellular lipid droplets (HP:0006565)2.33473063
71Clumsiness (HP:0002312)2.29706258
72Urinary bladder sphincter dysfunction (HP:0002839)2.26775777
73Hyperventilation (HP:0002883)2.25932712
74Hip dysplasia (HP:0001385)2.25893540
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.24749391
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24749391
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.22677416
78Oligodactyly (hands) (HP:0001180)2.22458346
79Infertility (HP:0000789)2.22046920
80Amblyopia (HP:0000646)2.20652927
81Hypothermia (HP:0002045)2.18301106
82Poikilocytosis (HP:0004447)2.17593974
83Renal cortical cysts (HP:0000803)2.17390366
84Megalencephaly (HP:0001355)2.16971021
85Decreased testicular size (HP:0008734)2.16825963
86Lipid accumulation in hepatocytes (HP:0006561)2.15777646
87Gaze-evoked nystagmus (HP:0000640)2.14666910
88Hepatic necrosis (HP:0002605)2.13269342
89Anxiety (HP:0000739)2.12804132
90Specific learning disability (HP:0001328)2.12453385
91Inability to walk (HP:0002540)2.11345725
92Atrophy/Degeneration involving motor neurons (HP:0007373)2.11281533
93Labial hypoplasia (HP:0000066)2.10264079
94Methylmalonic aciduria (HP:0012120)2.09558900
95Hepatocellular necrosis (HP:0001404)2.08214658
96Rhinitis (HP:0012384)2.07226877
97Abnormal ciliary motility (HP:0012262)2.07194544
98Pachygyria (HP:0001302)2.05876418
99Short tibia (HP:0005736)2.05674662
100Bradykinesia (HP:0002067)2.04969812
101Type II lissencephaly (HP:0007260)2.04430078
102Shoulder girdle muscle weakness (HP:0003547)2.04313589
103Agitation (HP:0000713)2.04103247
104Impaired social interactions (HP:0000735)2.03330583
105Abnormal social behavior (HP:0012433)2.03330583
106Split foot (HP:0001839)2.02555782
107Poor coordination (HP:0002370)2.01150948
108Optic nerve hypoplasia (HP:0000609)1.99668024
109Muscular hypotonia of the trunk (HP:0008936)1.98632721
110Aplasia/Hypoplasia of the tibia (HP:0005772)1.97924939
111Pancreatic fibrosis (HP:0100732)1.97867860
112Postural instability (HP:0002172)1.97526900
113Ankyloglossia (HP:0010296)1.96634924
114Insomnia (HP:0100785)1.95843282
115Obstructive sleep apnea (HP:0002870)1.95172582
116Cerebral hemorrhage (HP:0001342)1.94045322
117Abnormality of the musculature of the pelvis (HP:0001469)1.93936378
118Abnormality of the hip-girdle musculature (HP:0001445)1.93936378
119Broad foot (HP:0001769)1.93523172
120Hypoplastic female external genitalia (HP:0012815)1.93363826
121Morphological abnormality of the pyramidal tract (HP:0002062)1.91249419
122Cortical dysplasia (HP:0002539)1.91214272
123Colon cancer (HP:0003003)1.90656296
124Personality changes (HP:0000751)1.90400590
125Torticollis (HP:0000473)1.90239433
126True hermaphroditism (HP:0010459)1.89349940
127X-linked dominant inheritance (HP:0001423)1.88869006
128Neuronal loss in central nervous system (HP:0002529)1.88240211
129Aqueductal stenosis (HP:0002410)1.87790350
130Urinary urgency (HP:0000012)1.85538321
131Generalized myoclonic seizures (HP:0002123)1.85052425
132Zonular cataract (HP:0010920)1.84450213
133Male infertility (HP:0003251)1.84381216
134Gait imbalance (HP:0002141)1.83611284
135Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82710051
136Postaxial hand polydactyly (HP:0001162)1.82604702
137Abnormality of salivation (HP:0100755)1.82092293
138Neuroendocrine neoplasm (HP:0100634)1.82018276
139Spastic tetraplegia (HP:0002510)1.81891097
140Impaired smooth pursuit (HP:0007772)1.81494276
141Optic disc pallor (HP:0000543)1.81411005
142Diminished movement (HP:0002374)1.81240889
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81026231
144Microglossia (HP:0000171)1.80742623
145Medulloblastoma (HP:0002885)1.80565597
146Molar tooth sign on MRI (HP:0002419)1.79206852
147Abnormality of midbrain morphology (HP:0002418)1.79206852
148Scrotal hypoplasia (HP:0000046)1.79026949
149Calf muscle hypertrophy (HP:0008981)1.78499054
150Pancreatic cysts (HP:0001737)1.77867356
151Cerebral edema (HP:0002181)1.76639559
152Impaired vibration sensation in the lower limbs (HP:0002166)1.76460972
153Septo-optic dysplasia (HP:0100842)1.74973912
154Hypercortisolism (HP:0001578)1.74569599
155Renal Fanconi syndrome (HP:0001994)1.74296506
156Retinal dysplasia (HP:0007973)1.72286231
157Dysmetria (HP:0001310)1.71770704
158Relative macrocephaly (HP:0004482)1.71425687
159Progressive microcephaly (HP:0000253)1.71346350
160Degeneration of anterior horn cells (HP:0002398)1.70637864
161Abnormality of the anterior horn cell (HP:0006802)1.70637864
162Abnormality of vitamin B metabolism (HP:0004340)1.70415994
163Spastic gait (HP:0002064)1.69859916
164Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68805916
165Tongue fasciculations (HP:0001308)1.68666875
166Heterochromia iridis (HP:0001100)1.68041080
167Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.67394882
168Stereotypic behavior (HP:0000733)1.66862191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.08366938
2MST42.98130812
3MAP3K92.96546220
4EPHA42.85898516
5NTRK32.84718961
6PNCK2.76556732
7TRIM282.72021775
8WNK32.70384509
9ARAF2.60190899
10RIPK42.59093689
11MINK12.35042419
12PINK12.32464560
13KSR22.19857109
14MAP2K72.17554159
15MAP3K42.16628259
16KSR12.14655584
17PLK22.05848992
18ERBB31.95145298
19MAP4K21.91850736
20MAP3K121.88971574
21PAK61.88095627
22DAPK21.60676435
23FRK1.54348384
24CASK1.52852612
25NTRK11.52758898
26DMPK1.48693528
27RAF11.41943375
28GRK51.41293345
29MAP3K21.41092138
30CDK191.39853737
31NTRK21.37115534
32CSNK1G11.28622383
33BUB11.27034746
34PRKD31.26688245
35TESK11.26311045
36LMTK21.24017621
37NME11.22873989
38DYRK1A1.22379956
39NUAK11.21086701
40DYRK31.18384582
41LATS21.17804229
42SCYL21.16592173
43MAP2K41.15803264
44EIF2AK11.14324089
45CSNK1A1L1.14131434
46TYRO31.12119171
47CDK51.11160480
48ALK1.08094850
49PTK2B1.03411560
50CDK141.01952415
51MAPK131.01630014
52TAOK11.01283303
53DYRK20.99255032
54CDK180.97314836
55CDK150.95471566
56CAMKK20.93446832
57STK160.92850000
58STK110.92459909
59PRKCG0.90868854
60BCKDK0.90578758
61DAPK10.90152883
62NEK10.89261804
63GRK60.88159123
64CSNK1G20.85458591
65CDK11A0.85455053
66PDK30.81814094
67PDK40.81814094
68TSSK60.80893108
69UHMK10.79212852
70PIM20.78773425
71TNIK0.78032902
72CAMK2B0.76988038
73GRK10.76843360
74SIK30.75933976
75CAMK2A0.75852931
76FGR0.75740037
77RET0.74213627
78RPS6KA40.73601880
79STK390.72728889
80VRK10.72664747
81CCNB10.72587707
82INSRR0.72371961
83OBSCN0.71534189
84OXSR10.69603124
85MAP2K10.67308929
86MAPKAPK50.67247535
87SRPK10.66819640
88WEE10.66617009
89FGFR20.64193831
90CAMKK10.63972438
91LIMK10.63831300
92PLK40.63096030
93PAK30.62341601
94BMPR1B0.62121029
95MAP3K60.61568151
96BMPR20.60916317
97PDK20.59875555
98ICK0.58919571
99ZAK0.57224427
100MKNK20.57103168
101CAMK2D0.57084047
102PLK10.56066132
103ACVR1B0.55071834
104STK380.54863280
105EPHB20.54449911
106MAP3K10.54326101
107PDK10.51211450
108BCR0.51033358
109BRAF0.49442757
110CSNK1G30.48649208
111ABL20.48158764
112PHKG10.48031013
113PHKG20.48031013
114PDPK10.47913869
115ADRBK20.47456082
116SGK2230.47180618
117SGK4940.47180618
118WNK40.46803798
119PRKCZ0.46017464
120PRKACB0.45123011
121CAMK40.44543402
122MKNK10.43956693
123SGK20.43416767
124PIK3CA0.43039388
125PRKACA0.42341057
126GRK70.41873180
127ADRBK10.39976431
128FYN0.38766264
129RPS6KA20.38441519
130SIK20.38351509
131MAP3K130.38146075
132CSNK1E0.36645677
133PRKCI0.36464745
134SYK0.36425335
135DYRK1B0.35575661
136PRKCE0.34724987
137PLK30.34259008
138PRKG10.34241849
139EGFR0.33207761
140PKN10.32785536
141FGFR10.32649909
142CSNK1D0.32269527
143CAMK2G0.32134126
144CDK30.30914801
145CSNK1A10.30855426
146ROCK10.29960173
147PASK0.28264567

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.77177897
2Synaptic vesicle cycle_Homo sapiens_hsa047212.97657259
3Nicotine addiction_Homo sapiens_hsa050332.74303318
4Long-term potentiation_Homo sapiens_hsa047202.34006984
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33063044
6Olfactory transduction_Homo sapiens_hsa047402.31052754
7Collecting duct acid secretion_Homo sapiens_hsa049662.10743186
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07146730
9Amphetamine addiction_Homo sapiens_hsa050312.05739040
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98057864
11Circadian entrainment_Homo sapiens_hsa047131.91880608
12GABAergic synapse_Homo sapiens_hsa047271.91251987
13Dopaminergic synapse_Homo sapiens_hsa047281.87543229
14Glutamatergic synapse_Homo sapiens_hsa047241.84747455
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79074654
16Morphine addiction_Homo sapiens_hsa050321.78218362
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75215631
18Dorso-ventral axis formation_Homo sapiens_hsa043201.72610073
19Fatty acid elongation_Homo sapiens_hsa000621.70950543
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67879683
21Steroid biosynthesis_Homo sapiens_hsa001001.67158819
22Salivary secretion_Homo sapiens_hsa049701.66914751
23Propanoate metabolism_Homo sapiens_hsa006401.64831886
24Long-term depression_Homo sapiens_hsa047301.61533953
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54087751
26Regulation of autophagy_Homo sapiens_hsa041401.53372369
27Circadian rhythm_Homo sapiens_hsa047101.49509352
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48683347
29Serotonergic synapse_Homo sapiens_hsa047261.47994112
30Axon guidance_Homo sapiens_hsa043601.44255862
31Vibrio cholerae infection_Homo sapiens_hsa051101.42377039
32Gastric acid secretion_Homo sapiens_hsa049711.40983307
33Taste transduction_Homo sapiens_hsa047421.39216139
34Cholinergic synapse_Homo sapiens_hsa047251.35700929
35Proteasome_Homo sapiens_hsa030501.35259552
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34280238
37Oocyte meiosis_Homo sapiens_hsa041141.32571897
38Renin secretion_Homo sapiens_hsa049241.30700809
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26660094
40Folate biosynthesis_Homo sapiens_hsa007901.24546298
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24090936
42Basal transcription factors_Homo sapiens_hsa030221.24064102
43Oxytocin signaling pathway_Homo sapiens_hsa049211.18201525
44RNA polymerase_Homo sapiens_hsa030201.17511172
45Renal cell carcinoma_Homo sapiens_hsa052111.16304323
46GnRH signaling pathway_Homo sapiens_hsa049121.16259663
47VEGF signaling pathway_Homo sapiens_hsa043701.15191805
48Butanoate metabolism_Homo sapiens_hsa006501.14851452
49Glioma_Homo sapiens_hsa052141.12808225
50Cocaine addiction_Homo sapiens_hsa050301.10973885
51Estrogen signaling pathway_Homo sapiens_hsa049151.10643043
52ErbB signaling pathway_Homo sapiens_hsa040121.09747468
53Gap junction_Homo sapiens_hsa045401.07897557
54RNA degradation_Homo sapiens_hsa030181.04754576
55Rheumatoid arthritis_Homo sapiens_hsa053231.04663251
56Mismatch repair_Homo sapiens_hsa034301.03811978
57Insulin secretion_Homo sapiens_hsa049111.03461040
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02189855
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01331026
60Alcoholism_Homo sapiens_hsa050340.98361020
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.98012358
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.91496155
63Calcium signaling pathway_Homo sapiens_hsa040200.90719617
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90465476
65Melanogenesis_Homo sapiens_hsa049160.90256619
66Fanconi anemia pathway_Homo sapiens_hsa034600.89657396
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89290178
68Vitamin B6 metabolism_Homo sapiens_hsa007500.89281895
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88653226
70Peroxisome_Homo sapiens_hsa041460.88438883
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87443015
72Salmonella infection_Homo sapiens_hsa051320.86904864
73Colorectal cancer_Homo sapiens_hsa052100.86235362
74cAMP signaling pathway_Homo sapiens_hsa040240.85681685
75Pancreatic secretion_Homo sapiens_hsa049720.85467491
76Chemokine signaling pathway_Homo sapiens_hsa040620.85409355
77Phagosome_Homo sapiens_hsa041450.84925279
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84435887
79Alzheimers disease_Homo sapiens_hsa050100.82426945
80Oxidative phosphorylation_Homo sapiens_hsa001900.82049119
81Choline metabolism in cancer_Homo sapiens_hsa052310.81805402
82MAPK signaling pathway_Homo sapiens_hsa040100.80922862
83Cardiac muscle contraction_Homo sapiens_hsa042600.79582803
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79305901
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77989067
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77059663
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76491547
88Fat digestion and absorption_Homo sapiens_hsa049750.75775317
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75462047
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74390142
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73651231
92Ras signaling pathway_Homo sapiens_hsa040140.73360883
93Wnt signaling pathway_Homo sapiens_hsa043100.73235309
94* Endocytosis_Homo sapiens_hsa041440.73108224
95Sulfur metabolism_Homo sapiens_hsa009200.72208876
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.71705576
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70727315
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70598324
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69484894
100Phototransduction_Homo sapiens_hsa047440.68877706
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68278917
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68259678
103Parkinsons disease_Homo sapiens_hsa050120.68234216
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67195044
105Homologous recombination_Homo sapiens_hsa034400.66487890
106Linoleic acid metabolism_Homo sapiens_hsa005910.66422529
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65943315
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65798549
109Shigellosis_Homo sapiens_hsa051310.65473221
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.64989398
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64174275
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63759714
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63588604
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62282816
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61693097
116Pancreatic cancer_Homo sapiens_hsa052120.59957614
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59847933
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59661372
119Huntingtons disease_Homo sapiens_hsa050160.59528451
120Endometrial cancer_Homo sapiens_hsa052130.59156952
121Tuberculosis_Homo sapiens_hsa051520.58205998
122T cell receptor signaling pathway_Homo sapiens_hsa046600.56859792
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56765525
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56645750
125Mineral absorption_Homo sapiens_hsa049780.56612990
126Prion diseases_Homo sapiens_hsa050200.55821413
127Osteoclast differentiation_Homo sapiens_hsa043800.54395943
128Selenocompound metabolism_Homo sapiens_hsa004500.54335817
129Rap1 signaling pathway_Homo sapiens_hsa040150.54085051
130Pyruvate metabolism_Homo sapiens_hsa006200.54023686
131Tight junction_Homo sapiens_hsa045300.52541826
132Nitrogen metabolism_Homo sapiens_hsa009100.51849849
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51569600
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51352087
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50528549
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.49830932
137Non-small cell lung cancer_Homo sapiens_hsa052230.49782349
138Metabolic pathways_Homo sapiens_hsa011000.48942911
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48722028
140Arginine and proline metabolism_Homo sapiens_hsa003300.48680794
141Ether lipid metabolism_Homo sapiens_hsa005650.48052081
142Hedgehog signaling pathway_Homo sapiens_hsa043400.47888950
143Type II diabetes mellitus_Homo sapiens_hsa049300.46696708
144Hippo signaling pathway_Homo sapiens_hsa043900.46042379
145beta-Alanine metabolism_Homo sapiens_hsa004100.45638978
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44911171
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43216848
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42373381
149Purine metabolism_Homo sapiens_hsa002300.41965533
150Cysteine and methionine metabolism_Homo sapiens_hsa002700.41064228
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40566992
152Basal cell carcinoma_Homo sapiens_hsa052170.39931433

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