SMARCA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SWI/SNF family of proteins. The encoded protein is an ATPase which is expressed in diverse tissues and contributes to the chromatin remodeling complex that is involved in transcription. The protein may also play a role in DNA damage, growth inhibition and apoptosis of cancer cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20273223
2synaptic vesicle maturation (GO:0016188)4.41858408
3vocalization behavior (GO:0071625)4.39651503
4innervation (GO:0060384)4.19498321
5neuron cell-cell adhesion (GO:0007158)4.10907957
6glycine transport (GO:0015816)4.01410781
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97701896
8synaptic vesicle exocytosis (GO:0016079)3.94379740
9cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.86760501
10regulation of synaptic vesicle exocytosis (GO:2000300)3.68803551
11paraxial mesoderm development (GO:0048339)3.63137020
12response to follicle-stimulating hormone (GO:0032354)3.59162731
13regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.57814053
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.53258140
15positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.52232712
16protein localization to synapse (GO:0035418)3.42024103
17positive regulation of synaptic transmission, GABAergic (GO:0032230)3.37881572
18positive regulation of synapse assembly (GO:0051965)3.36765365
19positive regulation of amino acid transport (GO:0051957)3.35890179
20neuron recognition (GO:0008038)3.33760580
21positive regulation of male gonad development (GO:2000020)3.32567644
22layer formation in cerebral cortex (GO:0021819)3.31275167
23positive regulation of peptidyl-threonine phosphorylation (GO:0010800)3.31246428
24locomotory exploration behavior (GO:0035641)3.31089242
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28698014
26dendritic spine morphogenesis (GO:0060997)3.28192555
27regulation of non-canonical Wnt signaling pathway (GO:2000050)3.28131609
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26476355
29regulation of glutamate receptor signaling pathway (GO:1900449)3.24819883
30positive regulation of vesicle fusion (GO:0031340)3.24509918
31axonal fasciculation (GO:0007413)3.23488607
32glucocorticoid biosynthetic process (GO:0006704)3.22896682
33regulation of synaptic vesicle transport (GO:1902803)3.22036629
34glutamate secretion (GO:0014047)3.17542532
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.17041256
36axon extension involved in axon guidance (GO:0048846)3.15237086
37neuron projection extension involved in neuron projection guidance (GO:1902284)3.15237086
38growth hormone secretion (GO:0030252)3.13897280
39regulation of calcium ion-dependent exocytosis (GO:0017158)3.12334274
40regulation of vesicle fusion (GO:0031338)3.11891900
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07173000
42exploration behavior (GO:0035640)3.05874808
43regulation of transforming growth factor beta2 production (GO:0032909)3.03337456
44mating behavior (GO:0007617)3.03298472
45neurotransmitter secretion (GO:0007269)3.01154023
46embryonic foregut morphogenesis (GO:0048617)3.00918228
47neuron-neuron synaptic transmission (GO:0007270)2.98881994
48striatum development (GO:0021756)2.97579761
49synaptic vesicle endocytosis (GO:0048488)2.97491269
50synaptic transmission, glutamatergic (GO:0035249)2.94764626
51detection of calcium ion (GO:0005513)2.94531543
52mechanosensory behavior (GO:0007638)2.93370579
53negative regulation of JUN kinase activity (GO:0043508)2.92875833
54urinary tract smooth muscle contraction (GO:0014848)2.91779193
55anterior/posterior axis specification, embryo (GO:0008595)2.90618293
56ionotropic glutamate receptor signaling pathway (GO:0035235)2.89040251
57regulation of cardioblast differentiation (GO:0051890)2.87593286
58positive regulation of hormone biosynthetic process (GO:0046886)2.87295238
59positive regulation of synapse maturation (GO:0090129)2.87255786
60regulation of male gonad development (GO:2000018)2.85281466
61dendrite development (GO:0016358)2.85125613
62regulation of long-term neuronal synaptic plasticity (GO:0048169)2.84101654
63presynaptic membrane assembly (GO:0097105)2.79515692
64regulation of synapse assembly (GO:0051963)2.79179875
65regulation of neuronal synaptic plasticity (GO:0048168)2.77648439
66startle response (GO:0001964)2.77416063
67regulation of cAMP-dependent protein kinase activity (GO:2000479)2.76901982
68notochord development (GO:0030903)2.76056884
69G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71984579
70response to pheromone (GO:0019236)2.71573604
71glutamate receptor signaling pathway (GO:0007215)2.70406283
72cholesterol biosynthetic process (GO:0006695)2.69744746
73long-term synaptic potentiation (GO:0060291)2.66397325
74positive regulation of dendritic spine morphogenesis (GO:0061003)2.65952186
75endocardial cushion morphogenesis (GO:0003203)2.65913040
76chondrocyte proliferation (GO:0035988)2.65013815
77transmission of nerve impulse (GO:0019226)2.64660105
78glucocorticoid metabolic process (GO:0008211)2.64071660
79regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63970087
80regulation of postsynaptic membrane potential (GO:0060078)2.63630509
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.63026469
82embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60917087
83pyrimidine nucleobase catabolic process (GO:0006208)2.60600723
84androgen biosynthetic process (GO:0006702)2.59961924
85negative chemotaxis (GO:0050919)2.58659045
86regulation of dendritic spine morphogenesis (GO:0061001)2.58154576
87negative regulation of axon guidance (GO:1902668)2.57755729
88dendrite morphogenesis (GO:0048813)2.57215323
89retinal ganglion cell axon guidance (GO:0031290)2.56479229
90regulation of synapse structural plasticity (GO:0051823)2.56309660
91positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.55852765
92cell migration involved in sprouting angiogenesis (GO:0002042)2.55366985
93presynaptic membrane organization (GO:0097090)2.55008667
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.50207912
95cerebellum development (GO:0021549)2.48208977
96postsynaptic membrane organization (GO:0001941)2.48124374
97regulation of synaptic transmission, GABAergic (GO:0032228)2.47162214
98regulation of synapse organization (GO:0050807)2.47098897
99dopamine biosynthetic process (GO:0042416)2.46507742
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46493266
101regulation of cardioblast proliferation (GO:0003264)2.46210166
102regulation of secondary heart field cardioblast proliferation (GO:0003266)2.46210166
103nephron tubule morphogenesis (GO:0072078)2.45499038
104nephron epithelium morphogenesis (GO:0072088)2.45499038
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.45392072
106convergent extension (GO:0060026)2.45083098
107regulation of respiratory system process (GO:0044065)2.44567144
108regulation of neurotransmitter secretion (GO:0046928)2.43362302
109cellular response to gonadotropin stimulus (GO:0071371)2.43096830
110male genitalia development (GO:0030539)2.42964853
111dendritic spine organization (GO:0097061)2.42735276
112neurotransmitter transport (GO:0006836)2.42718860
113neurotransmitter-gated ion channel clustering (GO:0072578)2.42488008
114auditory behavior (GO:0031223)2.42392041
115synapse assembly (GO:0007416)2.42250976
116mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.40966571
117positive regulation of insulin secretion (GO:0032024)2.40936848
118artery smooth muscle contraction (GO:0014824)2.40741887
119regulation of fibrinolysis (GO:0051917)2.40740769
120cell migration in hindbrain (GO:0021535)2.39775369
121intestinal cholesterol absorption (GO:0030299)2.39764737
122negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.39335310
123neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.38186863
124regulation of axon guidance (GO:1902667)2.37597230
125membrane hyperpolarization (GO:0060081)2.37442011
126synapse organization (GO:0050808)2.37284812
127cerebellar Purkinje cell differentiation (GO:0021702)2.37265533
128apical protein localization (GO:0045176)2.37101612
129establishment of synaptic vesicle localization (GO:0097480)2.36904082
130synaptic vesicle transport (GO:0048489)2.36904082
131insulin secretion (GO:0030073)2.36782636
132proline transport (GO:0015824)2.36741194
133activation of protein kinase A activity (GO:0034199)2.36673371
134negative regulation of fibrinolysis (GO:0051918)2.36662299
135negative regulation of axon extension involved in axon guidance (GO:0048843)2.34941694
136sterol biosynthetic process (GO:0016126)2.34727531
137dorsal/ventral axis specification (GO:0009950)2.33423689
138peptidyl-glutamic acid carboxylation (GO:0017187)2.30195211
139protein carboxylation (GO:0018214)2.30195211
140limb bud formation (GO:0060174)2.29526900
141estrogen biosynthetic process (GO:0006703)2.26546925
142hippo signaling (GO:0035329)2.25823664
143high-density lipoprotein particle remodeling (GO:0034375)2.22430490
144positive regulation of hormone metabolic process (GO:0032352)2.22167823
145reverse cholesterol transport (GO:0043691)2.21423560
146response to gonadotropin (GO:0034698)2.21413801
147regulation of axon extension involved in axon guidance (GO:0048841)2.21221009
148planar cell polarity pathway involved in neural tube closure (GO:0090179)2.20389125
149anterior/posterior axis specification (GO:0009948)2.19894796
150mesenchymal cell proliferation (GO:0010463)2.19378843
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.18662581
152axon extension (GO:0048675)2.17486824
153gastrulation with mouth forming second (GO:0001702)2.17266762
154very-low-density lipoprotein particle assembly (GO:0034379)2.15696889
155ganglion development (GO:0061548)2.12199181
156ectodermal placode formation (GO:0060788)2.12067323
157mesenchymal to epithelial transition (GO:0060231)2.09517014
158lung-associated mesenchyme development (GO:0060484)2.07567873
159negative regulation of chondrocyte differentiation (GO:0032331)2.06286157
160low-density lipoprotein particle clearance (GO:0034383)2.05117304
161COPII vesicle coating (GO:0048208)2.04728786
162positive regulation of smoothened signaling pathway (GO:0045880)2.04122818
163cholesterol efflux (GO:0033344)2.03836783
164plasma lipoprotein particle assembly (GO:0034377)2.03296525
165kidney morphogenesis (GO:0060993)2.02214185
166cell adhesion mediated by integrin (GO:0033627)2.01736207
167body morphogenesis (GO:0010171)2.01510411
168collagen fibril organization (GO:0030199)1.99826138
169short-term memory (GO:0007614)1.99331342
170eye photoreceptor cell differentiation (GO:0001754)1.98705126
171photoreceptor cell differentiation (GO:0046530)1.98705126
172craniofacial suture morphogenesis (GO:0097094)1.98226385
173regulation of protein activation cascade (GO:2000257)1.97580013
174SMAD protein signal transduction (GO:0060395)1.96801104
175negative regulation of catenin import into nucleus (GO:0035414)1.96723842
176cell proliferation involved in kidney development (GO:0072111)1.95897683
177nucleobase catabolic process (GO:0046113)1.95877081
178gap junction assembly (GO:0016264)1.95111823
179macromolecular complex remodeling (GO:0034367)1.95100206
180plasma lipoprotein particle remodeling (GO:0034369)1.95100206
181protein-lipid complex remodeling (GO:0034368)1.95100206
182reproductive system development (GO:0061458)1.94632754
183regulation of steroid hormone biosynthetic process (GO:0090030)1.94630153
184retina vasculature morphogenesis in camera-type eye (GO:0061299)1.94499287
185regulation of establishment of planar polarity (GO:0090175)1.91163806
186Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.90934093
187regulation of complement activation (GO:0030449)1.89857317
188regulation of gonadotropin secretion (GO:0032276)1.87543664
189regulation of plasminogen activation (GO:0010755)1.87538074
190plasma lipoprotein particle clearance (GO:0034381)1.87236150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.04601845
2GBX2_23144817_ChIP-Seq_PC3_Human3.43275887
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79718606
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78170952
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71441239
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71204205
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.58950103
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47347861
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35923146
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34553633
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30438892
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30438892
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25394658
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20839028
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.18965936
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.18630477
17IGF1R_20145208_ChIP-Seq_DFB_Human2.17211254
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07739030
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06400389
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06328712
21REST_21632747_ChIP-Seq_MESCs_Mouse2.05715467
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05398022
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01841126
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.00980167
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.97138262
26VDR_22108803_ChIP-Seq_LS180_Human1.94682090
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.93633138
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92660739
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89720467
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88625475
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87943267
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87405586
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87387088
34TAF15_26573619_Chip-Seq_HEK293_Human1.85931468
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.85186608
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.84427209
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81413760
38AR_21909140_ChIP-Seq_LNCAP_Human1.78775176
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78141513
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.76282611
41SMAD4_21799915_ChIP-Seq_A2780_Human1.74778247
42FUS_26573619_Chip-Seq_HEK293_Human1.73935672
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73916919
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.72002413
45P300_19829295_ChIP-Seq_ESCs_Human1.71010314
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66017945
47DROSHA_22980978_ChIP-Seq_HELA_Human1.63673273
48* RNF2_27304074_Chip-Seq_NSC_Mouse1.63671701
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63173600
50CLOCK_20551151_ChIP-Seq_293T_Human1.61596314
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59386467
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59149092
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.57213348
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55499775
55ZNF274_21170338_ChIP-Seq_K562_Hela1.52103732
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51447503
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50584146
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49050610
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48854392
60AR_21572438_ChIP-Seq_LNCaP_Human1.46036807
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42125002
62STAT3_23295773_ChIP-Seq_U87_Human1.41864815
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41624530
64* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41261814
65* SMAD3_21741376_ChIP-Seq_EPCs_Human1.40843227
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38944507
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38602841
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38585870
69ISL1_27105846_Chip-Seq_CPCs_Mouse1.36529899
70TBX3_20139965_ChIP-Seq_MESCs_Mouse1.32799592
71TBX3_20139965_ChIP-Seq_ESCs_Mouse1.32361572
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.31872226
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31569337
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31420024
75EWS_26573619_Chip-Seq_HEK293_Human1.30532450
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30237385
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27286732
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26878831
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.26621507
80* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25614912
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.22370310
82* FOXA2_19822575_ChIP-Seq_HepG2_Human1.21788367
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.21552305
84TCF4_23295773_ChIP-Seq_U87_Human1.20722303
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20183202
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19689702
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18937270
88AR_25329375_ChIP-Seq_VCAP_Human1.18410176
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18189185
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16208177
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15540105
92SOX9_26525672_Chip-Seq_HEART_Mouse1.15417321
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15360516
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15360516
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.14744420
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14113078
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.13987385
98* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13797293
99AR_19668381_ChIP-Seq_PC3_Human1.13594960
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12970589
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.10871928
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10713439
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10031240
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09182199
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.08872448
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08419537
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07604555
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07410113
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06283304
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05942001
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.05938633
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05785433
113ER_23166858_ChIP-Seq_MCF-7_Human1.05451231
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03797313
115CJUN_26792858_Chip-Seq_BT549_Human1.03790098
116TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03624431
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03561934
118BCAT_22108803_ChIP-Seq_LS180_Human1.02497209
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02436138
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02130677
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02130677
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01588309
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00359257
124SALL1_21062744_ChIP-ChIP_HESCs_Human0.99266705
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98951864
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.98365192
127* TP53_18474530_ChIP-ChIP_U2OS_Human0.98228197
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98056848
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97993609
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97988872
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97667529
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97576039
133OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97348913
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.97274893
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96684843
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96683429
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.96262951
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95110321
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93928937
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93541521
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93539647
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.92065168
143JUN_21703547_ChIP-Seq_K562_Human0.91493753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.04235721
2MP0004859_abnormal_synaptic_plasticity3.24430379
3MP0004270_analgesia2.91945193
4MP0003880_abnormal_central_pattern2.81923497
5MP0000013_abnormal_adipose_tissue2.77188421
6MP0004272_abnormal_basement_membrane2.67461210
7MP0005645_abnormal_hypothalamus_physiol2.62155335
8MP0003635_abnormal_synaptic_transmissio2.58578590
9MP0002909_abnormal_adrenal_gland2.50607341
10MP0003121_genomic_imprinting2.35007580
11MP0008438_abnormal_cutaneous_collagen2.32941878
12MP0002063_abnormal_learning/memory/cond2.25229982
13MP0002734_abnormal_mechanical_nocicepti2.18050559
14MP0003123_paternal_imprinting2.17219133
15MP0009745_abnormal_behavioral_response2.10642067
16MP0010368_abnormal_lymphatic_system2.10513622
17MP0003787_abnormal_imprinting2.09707471
18MP0010386_abnormal_urinary_bladder2.09063690
19MP0003183_abnormal_peptide_metabolism2.07506093
20MP0002572_abnormal_emotion/affect_behav2.03616269
21MP0002735_abnormal_chemical_nociception1.99730946
22MP0002184_abnormal_innervation1.93613143
23MP0005423_abnormal_somatic_nervous1.93153120
24MP0006276_abnormal_autonomic_nervous1.92798844
25MP0000778_abnormal_nervous_system1.91759796
26MP0003937_abnormal_limbs/digits/tail_de1.87012098
27MP0000569_abnormal_digit_pigmentation1.84875336
28MP0002064_seizures1.80849389
29MP0001529_abnormal_vocalization1.80654615
30MP0006054_spinal_hemorrhage1.76940860
31MP0001968_abnormal_touch/_nociception1.76926886
32MP0002822_catalepsy1.76644344
33MP0002233_abnormal_nose_morphology1.69620678
34MP0002557_abnormal_social/conspecific_i1.69205152
35MP0002272_abnormal_nervous_system1.69063309
36MP0000566_synostosis1.69024603
37MP0003941_abnormal_skin_development1.66215425
38MP0009780_abnormal_chondrocyte_physiolo1.65480067
39MP0005257_abnormal_intraocular_pressure1.64971034
40MP0002733_abnormal_thermal_nociception1.62256090
41MP0002697_abnormal_eye_size1.61276034
42MP0003195_calcinosis1.60523067
43MP0009046_muscle_twitch1.55369697
44MP0002751_abnormal_autonomic_nervous1.54883911
45MP0003879_abnormal_hair_cell1.53567593
46MP0002837_dystrophic_cardiac_calcinosis1.53471276
47MP0001293_anophthalmia1.53118937
48MP0001486_abnormal_startle_reflex1.51869158
49MP0006072_abnormal_retinal_apoptosis1.51380853
50MP0009384_cardiac_valve_regurgitation1.47821074
51MP0000631_abnormal_neuroendocrine_gland1.47444006
52MP0002736_abnormal_nociception_after1.46124156
53MP0002938_white_spotting1.43360230
54MP0001970_abnormal_pain_threshold1.38546146
55MP0000639_abnormal_adrenal_gland1.38399941
56MP0003567_abnormal_fetal_cardiomyocyte1.38209833
57MP0005248_abnormal_Harderian_gland1.36062741
58MP0005379_endocrine/exocrine_gland_phen1.34231076
59MP0001440_abnormal_grooming_behavior1.33582534
60MP0003890_abnormal_embryonic-extraembry1.32594120
61MP0003119_abnormal_digestive_system1.32401167
62MP0008004_abnormal_stomach_pH1.30733192
63MP0005646_abnormal_pituitary_gland1.30176001
64MP0001188_hyperpigmentation1.29260156
65MP0002067_abnormal_sensory_capabilities1.28974198
66MP0003315_abnormal_perineum_morphology1.28011060
67MP0003755_abnormal_palate_morphology1.27804735
68MP0000955_abnormal_spinal_cord1.27773226
69MP0009053_abnormal_anal_canal1.27600753
70MP0005623_abnormal_meninges_morphology1.27552944
71MP0000003_abnormal_adipose_tissue1.27138199
72MP0005503_abnormal_tendon_morphology1.27060519
73MP0009250_abnormal_appendicular_skeleto1.26975547
74MP0005386_behavior/neurological_phenoty1.22956427
75MP0004924_abnormal_behavior1.22956427
76MP0001286_abnormal_eye_development1.22661577
77MP0001984_abnormal_olfaction1.17955022
78MP0004145_abnormal_muscle_electrophysio1.16349182
79MP0003935_abnormal_craniofacial_develop1.15496602
80MP0000462_abnormal_digestive_system1.15455463
81MP0003283_abnormal_digestive_organ1.14614296
82MP0006292_abnormal_olfactory_placode1.12841401
83MP0004811_abnormal_neuron_physiology1.11299138
84MP0001501_abnormal_sleep_pattern1.11102530
85MP0010329_abnormal_lipoprotein_level1.11097960
86MP0000428_abnormal_craniofacial_morphol1.10420074
87MP0004858_abnormal_nervous_system1.09546879
88MP0002102_abnormal_ear_morphology1.09238353
89MP0002882_abnormal_neuron_morphology1.08800768
90MP0002084_abnormal_developmental_patter1.05462008
91MP0004233_abnormal_muscle_weight1.04681115
92MP0001661_extended_life_span1.03485996
93MP0002282_abnormal_trachea_morphology0.99737238
94MP0009672_abnormal_birth_weight0.99413934
95MP0002092_abnormal_eye_morphology0.97441747
96MP0000049_abnormal_middle_ear0.96693561
97MP0001915_intracranial_hemorrhage0.95286822
98MP0000762_abnormal_tongue_morphology0.94707773
99MP0002152_abnormal_brain_morphology0.93734866
100MP0005499_abnormal_olfactory_system0.93388181
101MP0005394_taste/olfaction_phenotype0.93388181
102MP0002116_abnormal_craniofacial_bone0.93025745
103MP0003115_abnormal_respiratory_system0.92696954
104MP0002069_abnormal_eating/drinking_beha0.91789881
105MP0001905_abnormal_dopamine_level0.91724393
106MP0001944_abnormal_pancreas_morphology0.90938734
107MP0000432_abnormal_head_morphology0.90554591
108MP0002066_abnormal_motor_capabilities/c0.90525396
109MP0002108_abnormal_muscle_morphology0.90480456
110MP0001299_abnormal_eye_distance/0.90314230
111MP0002876_abnormal_thyroid_physiology0.89290200
112MP0000751_myopathy0.89238651
113MP0005365_abnormal_bile_salt0.89133140
114MP0000537_abnormal_urethra_morphology0.88010108
115MP0000516_abnormal_urinary_system0.87881312
116MP0005367_renal/urinary_system_phenotyp0.87881312
117MP0009703_decreased_birth_body0.87224395
118MP0003385_abnormal_body_wall0.87186762
119MP0005508_abnormal_skeleton_morphology0.86127586
120MP0001502_abnormal_circadian_rhythm0.86105931
121MP0004133_heterotaxia0.85888761
122MP0008789_abnormal_olfactory_epithelium0.85550891
123MP0002932_abnormal_joint_morphology0.85099085
124MP0002234_abnormal_pharynx_morphology0.84020617
125MP0002638_abnormal_pupillary_reflex0.84010785
126MP0002160_abnormal_reproductive_system0.84005591
127MP0003959_abnormal_lean_body0.82243951
128MP0002085_abnormal_embryonic_tissue0.81778609
129MP0003011_delayed_dark_adaptation0.81064454
130MP0005275_abnormal_skin_tensile0.81017284
131MP0003942_abnormal_urinary_system0.80945384
132MP0004215_abnormal_myocardial_fiber0.80739254
133MP0005084_abnormal_gallbladder_morpholo0.80502702
134MP0003868_abnormal_feces_composition0.80501441
135MP0003566_abnormal_cell_adhesion0.80486828
136MP0002109_abnormal_limb_morphology0.78955709
137MP0002163_abnormal_gland_morphology0.78469614
138MP0004085_abnormal_heartbeat0.78275117
139MP0003861_abnormal_nervous_system0.78202310
140MP0001485_abnormal_pinna_reflex0.78160244
141MP0005551_abnormal_eye_electrophysiolog0.77679572
142MP0005391_vision/eye_phenotype0.76743563
143MP0002752_abnormal_somatic_nervous0.76596719
144MP0010030_abnormal_orbit_morphology0.76463028
145MP0009697_abnormal_copulation0.76189694
146MP0002089_abnormal_postnatal_growth/wei0.74738409
147MP0005187_abnormal_penis_morphology0.74441527
148MP0005197_abnormal_uvea_morphology0.74258425
149MP0002090_abnormal_vision0.74139382
150MP0008961_abnormal_basal_metabolism0.73485793
151MP0002114_abnormal_axial_skeleton0.73159591
152MP0002081_perinatal_lethality0.73109664
153MP0008932_abnormal_embryonic_tissue0.72778918
154MP0005253_abnormal_eye_physiology0.72605220
155MP0002111_abnormal_tail_morphology0.72545301
156MP0003938_abnormal_ear_development0.71930852
157MP0000538_abnormal_urinary_bladder0.71125001
158MP0003137_abnormal_impulse_conducting0.70536981
159MP0001177_atelectasis0.70534174
160MP0002295_abnormal_pulmonary_circulatio0.69532491
161MP0000534_abnormal_ureter_morphology0.68454240
162MP0004197_abnormal_fetal_growth/weight/0.68373846
163MP0005085_abnormal_gallbladder_physiolo0.67866394
164MP0004043_abnormal_pH_regulation0.67464415
165MP0008569_lethality_at_weaning0.66709271
166MP0002896_abnormal_bone_mineralization0.65987884

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.06356546
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.78241126
3Hepatoblastoma (HP:0002884)3.45694006
4Abnormality of calcium-phosphate metabolism (HP:0100530)3.39141784
5Epileptic encephalopathy (HP:0200134)3.31841079
6Focal seizures (HP:0007359)3.17563674
7Protrusio acetabuli (HP:0003179)3.06545337
8Premature rupture of membranes (HP:0001788)3.05459693
9Agitation (HP:0000713)3.02980010
10Atonic seizures (HP:0010819)3.00418810
11Limb dystonia (HP:0002451)2.98803040
12Pheochromocytoma (HP:0002666)2.84347090
13Deep venous thrombosis (HP:0002625)2.83167042
14Epileptiform EEG discharges (HP:0011182)2.82444258
15Myokymia (HP:0002411)2.79646357
16EEG with generalized epileptiform discharges (HP:0011198)2.78265153
17Febrile seizures (HP:0002373)2.78007395
18Hypoventilation (HP:0002791)2.75179042
19Hyperglycemia (HP:0003074)2.71496628
20Bifid tongue (HP:0010297)2.70818635
21Visual hallucinations (HP:0002367)2.69067581
22Absence seizures (HP:0002121)2.68421945
23Blue irides (HP:0000635)2.67020508
24Menstrual irregularities (HP:0000858)2.66902921
25Hypsarrhythmia (HP:0002521)2.57889405
26Neonatal short-limb short stature (HP:0008921)2.51696176
27Gait imbalance (HP:0002141)2.47368349
28Rhizomelia (HP:0008905)2.45526623
29Hyperinsulinemic hypoglycemia (HP:0000825)2.44937784
30Progressive cerebellar ataxia (HP:0002073)2.44829325
31Neuroendocrine neoplasm (HP:0100634)2.44091361
32Abnormality of the fovea (HP:0000493)2.36888503
33Myelomeningocele (HP:0002475)2.36534532
34Hemiparesis (HP:0001269)2.36281584
35Hyperventilation (HP:0002883)2.32902315
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.32405170
37Hypoplasia of the fovea (HP:0007750)2.32405170
38Prolonged partial thromboplastin time (HP:0003645)2.30916432
39Large earlobe (HP:0009748)2.29690237
40Small epiphyses (HP:0010585)2.28822581
41Drooling (HP:0002307)2.27084253
42Excessive salivation (HP:0003781)2.27084253
43Dialeptic seizures (HP:0011146)2.24690242
44Testicular neoplasm (HP:0010788)2.23238520
45Labial hypoplasia (HP:0000066)2.22098842
46Papillary thyroid carcinoma (HP:0002895)2.20733390
47Neoplasm of the heart (HP:0100544)2.17816814
48Arterial tortuosity (HP:0005116)2.17339804
49Protruding tongue (HP:0010808)2.17123564
50Vertebral arch anomaly (HP:0008438)2.15210455
51Congenital primary aphakia (HP:0007707)2.14142414
52Retinal atrophy (HP:0001105)2.13091428
53Diastasis recti (HP:0001540)2.12450608
54Abnormality of carpal bone ossification (HP:0006257)2.11429072
55Absent speech (HP:0001344)2.11366002
56Broad-based gait (HP:0002136)2.10910283
57Hypothermia (HP:0002045)2.10222934
58Relative macrocephaly (HP:0004482)2.08557723
59Generalized tonic-clonic seizures (HP:0002069)2.07081455
60Vascular tortuosity (HP:0004948)2.05373850
61Soft skin (HP:0000977)2.04516821
62Amblyopia (HP:0000646)2.04307322
63Vertebral clefting (HP:0008428)2.02295783
64Failure to thrive in infancy (HP:0001531)2.01415891
65Coronal craniosynostosis (HP:0004440)2.00542142
66Enlarged kidneys (HP:0000105)2.00437156
67Medial flaring of the eyebrow (HP:0010747)2.00018263
68Vaginal atresia (HP:0000148)1.99426438
69Pancreatic islet-cell hyperplasia (HP:0004510)1.98699989
70Depression (HP:0000716)1.97462240
71Genital tract atresia (HP:0001827)1.97062293
72Vitreoretinal degeneration (HP:0000655)1.96887375
73Cutaneous finger syndactyly (HP:0010554)1.95502062
74Broad palm (HP:0001169)1.94949487
75Macroorchidism (HP:0000053)1.94784946
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94281427
77Absent epiphyses (HP:0010577)1.94281427
78Nephrogenic diabetes insipidus (HP:0009806)1.91444801
79Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88272655
80Mitral stenosis (HP:0001718)1.87358525
81Hypoplastic female external genitalia (HP:0012815)1.86580450
82Broad alveolar ridges (HP:0000187)1.85666454
83Abnormality of the alveolar ridges (HP:0006477)1.84905073
84Ankyloglossia (HP:0010296)1.84874945
85Hypoglycemic seizures (HP:0002173)1.84648328
86Shoulder girdle muscle weakness (HP:0003547)1.84552761
87Anxiety (HP:0000739)1.84117615
88Orthostatic hypotension (HP:0001278)1.83869984
89Aplasia/Hypoplasia of the lens (HP:0008063)1.81422793
90Buphthalmos (HP:0000557)1.80831540
91Atelectasis (HP:0100750)1.80751468
92Ankle clonus (HP:0011448)1.79156862
93Exotropia (HP:0000577)1.78695374
94Cupped ear (HP:0000378)1.78570924
95Hyperthyroidism (HP:0000836)1.78241656
96Morphological abnormality of the middle ear (HP:0008609)1.77617334
97Aortic dissection (HP:0002647)1.75555055
98Heterochromia iridis (HP:0001100)1.75380986
99Limited hip movement (HP:0008800)1.75370297
100Cutaneous syndactyly (HP:0012725)1.74650504
101Torticollis (HP:0000473)1.74049352
102Abnormal hand bone ossification (HP:0010660)1.73652493
103Hypobetalipoproteinemia (HP:0003563)1.72445500
104Arthropathy (HP:0003040)1.70383524
105Pulmonic stenosis (HP:0001642)1.69222275
106Omphalocele (HP:0001539)1.68636360
107Osteomalacia (HP:0002749)1.68038137
108Aplasia involving bones of the upper limbs (HP:0009823)1.67177215
109Aplasia of the phalanges of the hand (HP:0009802)1.67177215
110Aplasia involving bones of the extremities (HP:0009825)1.67177215
111Symptomatic seizures (HP:0011145)1.67081883
112Renal duplication (HP:0000075)1.66893331
113Ulnar bowing (HP:0003031)1.66485836
114Bronchomalacia (HP:0002780)1.64753924
115Wide anterior fontanel (HP:0000260)1.64691974
116Abnormal ossification of hand bones (HP:0005921)1.64175371
117Hypolipoproteinemia (HP:0010981)1.63847093
118Truncal ataxia (HP:0002078)1.63143636
119Mixed hearing impairment (HP:0000410)1.62714969
120Congenital glaucoma (HP:0001087)1.62693931
121Abnormal tarsal ossification (HP:0008369)1.61705099
122Transposition of the great arteries (HP:0001669)1.61661235
123Abnormal connection of the cardiac segments (HP:0011545)1.61661235
124Abnormal ventriculo-arterial connection (HP:0011563)1.61661235
125Hypoplastic labia majora (HP:0000059)1.61416867
126Limited elbow extension (HP:0001377)1.61414490
127Abnormality of the common coagulation pathway (HP:0010990)1.60797959
128Specific learning disability (HP:0001328)1.60402455
129Preaxial foot polydactyly (HP:0001841)1.60109294
130Anomalous pulmonary venous return (HP:0010772)1.59958717
131Abnormality of the pancreatic islet cells (HP:0006476)1.58789849
132Abnormality of endocrine pancreas physiology (HP:0012093)1.58789849
133Asymmetry of the thorax (HP:0001555)1.58070904
134Open mouth (HP:0000194)1.57686396
135Congenital malformation of the right heart (HP:0011723)1.57679885
136Double outlet right ventricle (HP:0001719)1.57679885
137Macroglossia (HP:0000158)1.57557739
138Downturned corners of mouth (HP:0002714)1.57140177
139Cortical dysplasia (HP:0002539)1.56947041
140Short humerus (HP:0005792)1.56311757
141Partial agenesis of the corpus callosum (HP:0001338)1.55791220
142Type II lissencephaly (HP:0007260)1.55746231
143Ectopic anus (HP:0004397)1.55431757
144Abnormal sex determination (HP:0012244)1.55052419
145Sex reversal (HP:0012245)1.55052419
146Occipital encephalocele (HP:0002085)1.54057755
147Focal dystonia (HP:0004373)1.54029038
148Amyotrophic lateral sclerosis (HP:0007354)1.53375381
149Hypoalphalipoproteinemia (HP:0003233)1.53365249
150Narrow nasal bridge (HP:0000446)1.52548926
151Delayed gross motor development (HP:0002194)1.52279951
152Neuroblastic tumors (HP:0004376)1.52190500
153Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.52190500
154Neuroblastoma (HP:0003006)1.52190500
155Primitive neuroectodermal tumor (HP:0030065)1.52190500
156Abnormality of dentin (HP:0010299)1.51785431
157Neoplasm of the peripheral nervous system (HP:0100007)1.51495153
158Absent eyebrow (HP:0002223)1.51259357
159Abnormality of the nasal septum (HP:0000419)1.51230548
160Thyroid carcinoma (HP:0002890)1.51164295
161Abnormal delivery (HP:0001787)1.50989644
162Shallow orbits (HP:0000586)1.50675783
163Irregular epiphyses (HP:0010582)1.49165754
164Hypercholesterolemia (HP:0003124)1.49024127
165Stenosis of the external auditory canal (HP:0000402)1.48977607
166Anophthalmia (HP:0000528)1.48876027
167Arnold-Chiari malformation (HP:0002308)1.48459875
168Abnormality of the pulmonary veins (HP:0011718)1.47986291
169Increased nuchal translucency (HP:0010880)1.47610962
170Increased number of teeth (HP:0011069)1.47422622
171Broad long bones (HP:0005622)1.45571134
172Impaired pain sensation (HP:0007328)1.45204568
173Abnormality of pain sensation (HP:0010832)1.45204568
174Abnormality of the acetabulum (HP:0003170)1.43922264
175Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.43638298
176Vertebral hypoplasia (HP:0008417)1.43638298
177Pterygium (HP:0001059)1.43463364
178Oligodactyly (hands) (HP:0001180)1.43029489
179Broad thumb (HP:0011304)1.42486687
180Aplasia/hypoplasia of the humerus (HP:0006507)1.41808787
181Intestinal atresia (HP:0011100)1.41496996
182Abnormality of the aortic arch (HP:0012303)1.41232484
183Supernumerary spleens (HP:0009799)1.41091328
184Periauricular skin pits (HP:0100277)1.40195665
185Preauricular pit (HP:0004467)1.40195665
186Hypoplastic pelvis (HP:0008839)1.40157527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK37.05078681
2NTRK33.53554476
3MARK13.01791898
4LATS12.81558437
5EPHA42.72390635
6CASK2.54523632
7MAP3K42.45322781
8MAPK152.30613651
9WNK42.03126776
10MINK11.98782239
11MAP3K91.96548342
12FGFR21.92327121
13PLK21.91400886
14KSR11.89248789
15UHMK11.88745644
16MAP2K71.74175689
17MKNK11.71626542
18TRIM281.69379287
19MKNK21.64159347
20MAP3K121.63940971
21FGFR11.61827874
22MAPK131.60130755
23NTRK21.55703617
24NTRK11.43497667
25PRKD31.42735238
26PNCK1.41041768
27ERBB31.37710025
28PAK31.37592680
29INSRR1.36890943
30FRK1.33533000
31FER1.33274001
32BCR1.30275327
33DAPK21.30224969
34GRK51.28697726
35PAK61.27726386
36ERBB41.27092280
37FGFR41.26002589
38DYRK1A1.25968518
39STK31.22835399
40KSR21.21988941
41SRPK11.20705649
42AKT31.19503364
43MAP2K41.18924535
44WNK11.10522444
45MAP3K21.08923639
46PKN21.05747689
47DMPK1.05701729
48BRSK21.05674384
49NEK21.05133629
50NEK11.04975231
51PRKCG1.02003597
52TTK1.01861121
53CDK51.00109272
54FGFR30.98123438
55CDC42BPA0.96745904
56DAPK10.95480315
57MET0.94291073
58PIK3CG0.93623674
59LATS20.91936336
60FLT30.89598194
61TSSK60.89440207
62CSNK1G20.89302962
63STK38L0.88962228
64DYRK1B0.88920479
65NEK90.87702332
66SIK30.87200976
67ICK0.83351784
68BMPR1B0.82761461
69ADRBK20.82220174
70SGK4940.81438534
71SGK2230.81438534
72DYRK20.81385303
73CAMK2A0.80280133
74NME10.79686027
75CAMK2B0.79571620
76WEE10.79557451
77SGK20.79091104
78CSNK1G30.78482476
79NLK0.74342996
80BMPR20.73016239
81PAK20.72727591
82DDR20.70746637
83PLK40.70567890
84CDK140.68971895
85CAMKK20.68595459
86PLK10.67778110
87PRKCE0.67226197
88ARAF0.66854701
89CDC70.66399792
90ROCK20.65741719
91CDK180.64896294
92LMTK20.62993121
93ADRBK10.62672186
94CAMK1D0.62577272
95SGK10.62053787
96TNIK0.61438180
97CAMK2D0.61365772
98EPHB20.60732915
99BUB10.60582409
100CSNK1G10.60221887
101ERBB20.59384750
102EIF2AK10.56441288
103CDK150.55824116
104CDK120.55216056
105ROCK10.54675565
106ATM0.54459200
107PLK30.54447976
108PHKG20.53346757
109PHKG10.53346757
110MYLK0.53089838
111CSNK1A1L0.52588955
112STK390.51572046
113TYRO30.51153132
114BRAF0.50983249
115BRD40.50148231
116RAF10.49439732
117SCYL20.49369110
118CAMKK10.49103512
119PIK3CA0.49080545
120EPHA30.48763287
121PTK2B0.48698019
122DYRK30.47567646
123CDK11A0.46714505
124PDGFRB0.46130309
125YES10.46063927
126TAF10.45776179
127RET0.45062301
128STK380.43277910
129CSNK1D0.43104840
130PRPF4B0.42180639
131MAP2K10.42019647
132PBK0.41697491
133MAPK100.41101088
134CAMK1G0.40775607
135PRKCH0.40630032
136PRKCZ0.39039659
137PDGFRA0.37666727
138RPS6KA30.37562668
139BRSK10.37223145
140PTK20.35676324
141MARK20.35160843
142PRKACA0.35023561
143LIMK10.34297245
144CSNK1E0.32843043
145CSNK1A10.32038548

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.53839451
2Nicotine addiction_Homo sapiens_hsa050333.18030416
3Synaptic vesicle cycle_Homo sapiens_hsa047212.78609597
4Insulin secretion_Homo sapiens_hsa049112.65096410
5GABAergic synapse_Homo sapiens_hsa047272.63898169
6Amphetamine addiction_Homo sapiens_hsa050312.61626533
7Circadian entrainment_Homo sapiens_hsa047132.54015084
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.38548421
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31973347
10Long-term potentiation_Homo sapiens_hsa047202.23809322
11Dopaminergic synapse_Homo sapiens_hsa047282.23013021
12Cocaine addiction_Homo sapiens_hsa050302.20476604
13Morphine addiction_Homo sapiens_hsa050322.19570019
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18467900
15Olfactory transduction_Homo sapiens_hsa047402.11827337
16Glutamatergic synapse_Homo sapiens_hsa047242.03845440
17Renin secretion_Homo sapiens_hsa049241.96221175
18Serotonergic synapse_Homo sapiens_hsa047261.94849644
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92987221
20Complement and coagulation cascades_Homo sapiens_hsa046101.86654539
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80346366
22Taste transduction_Homo sapiens_hsa047421.79819403
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78117888
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.75038080
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70582448
26Long-term depression_Homo sapiens_hsa047301.69573110
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64775927
28Propanoate metabolism_Homo sapiens_hsa006401.63348444
29Cholinergic synapse_Homo sapiens_hsa047251.63347185
30ECM-receptor interaction_Homo sapiens_hsa045121.61670208
31Collecting duct acid secretion_Homo sapiens_hsa049661.57720135
32Vibrio cholerae infection_Homo sapiens_hsa051101.57504872
33Salivary secretion_Homo sapiens_hsa049701.50352345
34Fatty acid metabolism_Homo sapiens_hsa012121.49725395
35Adherens junction_Homo sapiens_hsa045201.45912324
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44735255
37Axon guidance_Homo sapiens_hsa043601.43657789
38Oxytocin signaling pathway_Homo sapiens_hsa049211.42653769
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40253536
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39867349
41Gap junction_Homo sapiens_hsa045401.37125934
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35464432
43Calcium signaling pathway_Homo sapiens_hsa040201.34015759
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32092736
45TGF-beta signaling pathway_Homo sapiens_hsa043501.29150376
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29067709
47Gastric acid secretion_Homo sapiens_hsa049711.27483377
48Fatty acid degradation_Homo sapiens_hsa000711.24414542
49cAMP signaling pathway_Homo sapiens_hsa040241.24383413
50Pyruvate metabolism_Homo sapiens_hsa006201.23362980
51Vitamin B6 metabolism_Homo sapiens_hsa007501.23103192
52Type II diabetes mellitus_Homo sapiens_hsa049301.21072605
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.18145155
54Type I diabetes mellitus_Homo sapiens_hsa049401.18042151
55Cardiac muscle contraction_Homo sapiens_hsa042601.17832917
56Fatty acid elongation_Homo sapiens_hsa000621.15791645
57Fat digestion and absorption_Homo sapiens_hsa049751.15542610
58Melanogenesis_Homo sapiens_hsa049161.14997759
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14956395
60Estrogen signaling pathway_Homo sapiens_hsa049151.13902041
61Butanoate metabolism_Homo sapiens_hsa006501.13586544
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13181667
63Non-homologous end-joining_Homo sapiens_hsa034501.12691318
64GnRH signaling pathway_Homo sapiens_hsa049121.11434092
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10573359
66Vitamin digestion and absorption_Homo sapiens_hsa049771.06953822
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06775211
68Phototransduction_Homo sapiens_hsa047441.06015569
69Dilated cardiomyopathy_Homo sapiens_hsa054141.00397228
70Steroid hormone biosynthesis_Homo sapiens_hsa001401.00190195
71Alcoholism_Homo sapiens_hsa050340.99242654
72Hedgehog signaling pathway_Homo sapiens_hsa043400.99009407
73Wnt signaling pathway_Homo sapiens_hsa043100.98963541
74Fatty acid biosynthesis_Homo sapiens_hsa000610.98835248
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98005770
76Oxidative phosphorylation_Homo sapiens_hsa001900.94410954
77Glucagon signaling pathway_Homo sapiens_hsa049220.94344167
78Ovarian steroidogenesis_Homo sapiens_hsa049130.94129657
79Lysine degradation_Homo sapiens_hsa003100.93897345
80Protein export_Homo sapiens_hsa030600.92549935
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92090619
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91503269
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91182063
84Alzheimers disease_Homo sapiens_hsa050100.88727232
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87489454
86Selenocompound metabolism_Homo sapiens_hsa004500.86195735
87Focal adhesion_Homo sapiens_hsa045100.86083779
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85808034
89Thyroid hormone synthesis_Homo sapiens_hsa049180.85070226
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.83665658
91Oocyte meiosis_Homo sapiens_hsa041140.83483808
92Biosynthesis of amino acids_Homo sapiens_hsa012300.82804780
93Circadian rhythm_Homo sapiens_hsa047100.82337374
94Parkinsons disease_Homo sapiens_hsa050120.82128211
95Proteoglycans in cancer_Homo sapiens_hsa052050.80520360
96ErbB signaling pathway_Homo sapiens_hsa040120.80461509
97Arginine and proline metabolism_Homo sapiens_hsa003300.80105592
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80045173
99Starch and sucrose metabolism_Homo sapiens_hsa005000.76793949
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76225901
101Pancreatic secretion_Homo sapiens_hsa049720.74599383
102Endometrial cancer_Homo sapiens_hsa052130.73915579
103Arginine biosynthesis_Homo sapiens_hsa002200.73911885
104beta-Alanine metabolism_Homo sapiens_hsa004100.73574505
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73041280
106Prion diseases_Homo sapiens_hsa050200.72573716
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71206804
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71041592
109Glioma_Homo sapiens_hsa052140.70818938
110PPAR signaling pathway_Homo sapiens_hsa033200.70639559
111Carbon metabolism_Homo sapiens_hsa012000.69607144
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.68757358
113N-Glycan biosynthesis_Homo sapiens_hsa005100.67099487
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66751740
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66662902
116Histidine metabolism_Homo sapiens_hsa003400.66507882
117Bile secretion_Homo sapiens_hsa049760.65396538
118Huntingtons disease_Homo sapiens_hsa050160.63088975
119mRNA surveillance pathway_Homo sapiens_hsa030150.62061839
120Hippo signaling pathway_Homo sapiens_hsa043900.61403729
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60593951
122MAPK signaling pathway_Homo sapiens_hsa040100.56082755
123Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55878376
124Basal cell carcinoma_Homo sapiens_hsa052170.55140646
125Folate biosynthesis_Homo sapiens_hsa007900.55064481
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53344506
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53288322
128Choline metabolism in cancer_Homo sapiens_hsa052310.52634184
129MicroRNAs in cancer_Homo sapiens_hsa052060.52241582
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52100301
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51677869
132Ras signaling pathway_Homo sapiens_hsa040140.51583748
133Dorso-ventral axis formation_Homo sapiens_hsa043200.51535835
134Phenylalanine metabolism_Homo sapiens_hsa003600.51464941
135Tyrosine metabolism_Homo sapiens_hsa003500.51314677
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51151428
137Colorectal cancer_Homo sapiens_hsa052100.50754419
138Peroxisome_Homo sapiens_hsa041460.50718747
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.49490438
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.49001466
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48813211
142mTOR signaling pathway_Homo sapiens_hsa041500.47805926
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47728895
144Tight junction_Homo sapiens_hsa045300.47373556
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47254120
146Galactose metabolism_Homo sapiens_hsa000520.47049376
147Chemical carcinogenesis_Homo sapiens_hsa052040.46920192
148Renal cell carcinoma_Homo sapiens_hsa052110.46833703
149Thyroid cancer_Homo sapiens_hsa052160.46473714
150Rap1 signaling pathway_Homo sapiens_hsa040150.45636379
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45564074
152AMPK signaling pathway_Homo sapiens_hsa041520.45189760
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44916614
154RNA transport_Homo sapiens_hsa030130.44844471
155Glutathione metabolism_Homo sapiens_hsa004800.43432780
156Retinol metabolism_Homo sapiens_hsa008300.42836465
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.42748598
158Basal transcription factors_Homo sapiens_hsa030220.42572232
159Insulin signaling pathway_Homo sapiens_hsa049100.41353863
160Cell cycle_Homo sapiens_hsa041100.40844565
161Protein digestion and absorption_Homo sapiens_hsa049740.40817650
162Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39651754
163Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38581184
164Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37821528
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37120672
166Inositol phosphate metabolism_Homo sapiens_hsa005620.35686033
167Regulation of autophagy_Homo sapiens_hsa041400.30551153
168Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30112476
169SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29893975

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