SMARCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.61256801
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.48557054
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.44219567
4locomotory exploration behavior (GO:0035641)4.39008529
5vocalization behavior (GO:0071625)4.36666971
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.26001043
7synaptic vesicle maturation (GO:0016188)4.22477865
8negative regulation of erythrocyte differentiation (GO:0045647)4.20323040
9regulation of B cell receptor signaling pathway (GO:0050855)4.09080652
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.07758731
11B cell receptor signaling pathway (GO:0050853)4.03598192
12regulation of synaptic vesicle exocytosis (GO:2000300)3.87768922
13synaptic vesicle exocytosis (GO:0016079)3.86778564
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.86376372
15regulation of glutamate receptor signaling pathway (GO:1900449)3.83429904
16regulation of gamma-delta T cell differentiation (GO:0045586)3.83081245
17glutamate secretion (GO:0014047)3.80856178
18neurotransmitter-gated ion channel clustering (GO:0072578)3.75464690
19protein localization to synapse (GO:0035418)3.68313185
20neuron cell-cell adhesion (GO:0007158)3.67026291
21regulation of gamma-delta T cell activation (GO:0046643)3.66854960
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65022793
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.55419863
24neurotransmitter secretion (GO:0007269)3.51117708
25positive regulation of granulocyte differentiation (GO:0030854)3.47559514
26regulation of synaptic vesicle transport (GO:1902803)3.47471987
27exploration behavior (GO:0035640)3.46885249
28gamma-aminobutyric acid transport (GO:0015812)3.44494305
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.43559345
30negative regulation of cell killing (GO:0031342)3.43559345
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38516405
32cellular response to ethanol (GO:0071361)3.37232506
33positive thymic T cell selection (GO:0045059)3.36127138
34negative thymic T cell selection (GO:0045060)3.35824825
35positive regulation of Rap GTPase activity (GO:0032854)3.33975588
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32765006
37positive regulation of B cell differentiation (GO:0045579)3.27585840
38antigen processing and presentation of endogenous antigen (GO:0019883)3.23824255
39glutamate receptor signaling pathway (GO:0007215)3.23607380
40negative T cell selection (GO:0043383)3.23102712
41positive T cell selection (GO:0043368)3.20801717
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18979514
43regulation of neuronal synaptic plasticity (GO:0048168)3.16715239
44phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16024235
45germinal center formation (GO:0002467)3.15627581
46layer formation in cerebral cortex (GO:0021819)3.14124494
47synaptic transmission, glutamatergic (GO:0035249)3.11374600
48dendritic spine morphogenesis (GO:0060997)3.10821151
49cellular potassium ion homeostasis (GO:0030007)3.10117786
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08077621
51neuronal action potential propagation (GO:0019227)3.07514510
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05583533
53cerebellar Purkinje cell differentiation (GO:0021702)3.01443778
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01339545
55interkinetic nuclear migration (GO:0022027)3.00076978
56regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98590248
57neuron-neuron synaptic transmission (GO:0007270)2.97059329
58presynaptic membrane assembly (GO:0097105)2.96802825
59positive regulation of membrane potential (GO:0045838)2.96077122
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91822023
61definitive hemopoiesis (GO:0060216)2.91777850
62regulation of postsynaptic membrane potential (GO:0060078)2.89928808
63activation of protein kinase A activity (GO:0034199)2.88334997
64T cell selection (GO:0045058)2.87817569
65long-term memory (GO:0007616)2.85618860
66gamma-aminobutyric acid signaling pathway (GO:0007214)2.85392141
67neurotransmitter transport (GO:0006836)2.85060875
68neuron recognition (GO:0008038)2.84678430
69dendrite morphogenesis (GO:0048813)2.84627620
70thymic T cell selection (GO:0045061)2.83540613
71histone H3-K36 demethylation (GO:0070544)2.83005078
72postsynaptic membrane organization (GO:0001941)2.82892867
73regulation of Rap GTPase activity (GO:0032317)2.81363827
74regulation of synapse structural plasticity (GO:0051823)2.81259024
75proline transport (GO:0015824)2.80909307
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78572763
77histone H3-K4 trimethylation (GO:0080182)2.76394670
78regulation of synaptic transmission, glutamatergic (GO:0051966)2.74034400
79sodium ion export (GO:0071436)2.73676440
80synaptic vesicle endocytosis (GO:0048488)2.69831301
81regulation of B cell differentiation (GO:0045577)2.69063071
82axonal fasciculation (GO:0007413)2.68367401
83presynaptic membrane organization (GO:0097090)2.68305840
84regulation of neurotransmitter levels (GO:0001505)2.68009049
85membrane depolarization during action potential (GO:0086010)2.67613368
86regulation of ARF protein signal transduction (GO:0032012)2.67251464
87regulation of neurotransmitter secretion (GO:0046928)2.66723354
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66692020
89response to interleukin-15 (GO:0070672)2.66413881
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.66182201
91long-term synaptic potentiation (GO:0060291)2.64182833
92cerebellar granule cell differentiation (GO:0021707)2.64092158
93negative regulation of T cell mediated immunity (GO:0002710)2.62135435
94positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61741355
95B cell homeostasis (GO:0001782)2.61137904
96nerve growth factor signaling pathway (GO:0038180)2.59069377
97startle response (GO:0001964)2.58867700
98T cell migration (GO:0072678)2.57356125
99cellular extravasation (GO:0045123)2.57033189
100membrane depolarization (GO:0051899)2.55977226
101synapse assembly (GO:0007416)2.54497434
102regulation of synaptic plasticity (GO:0048167)2.54213079
103response to muramyl dipeptide (GO:0032495)2.54001411
104positive regulation of synapse maturation (GO:0090129)2.53430022
105prepulse inhibition (GO:0060134)2.53150510
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52943539
107establishment of protein localization to Golgi (GO:0072600)2.52879455
108membrane hyperpolarization (GO:0060081)2.52815647
109mannose metabolic process (GO:0006013)2.52653401
110regulation of dendritic spine morphogenesis (GO:0061001)2.52433613
111regulation of granulocyte differentiation (GO:0030852)2.52366164
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52279929
113retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51761268
114auditory behavior (GO:0031223)2.51229333
115cellular response to epinephrine stimulus (GO:0071872)2.50798943
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.50732927
117innervation (GO:0060384)2.50036665
118transmission of nerve impulse (GO:0019226)2.49376654
119negative regulation of lymphocyte mediated immunity (GO:0002707)2.49121094
120megakaryocyte development (GO:0035855)2.48895878
121phospholipid translocation (GO:0045332)2.48848882
122lipid translocation (GO:0034204)2.48848882
123positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.48646872
124response to histamine (GO:0034776)2.48242616
125glycine transport (GO:0015816)2.47731596
126regulation of neurotransmitter transport (GO:0051588)2.47315909
127suckling behavior (GO:0001967)2.43843132
128protein targeting to Golgi (GO:0000042)2.43238737
129cellular sodium ion homeostasis (GO:0006883)2.43038384
130regulation of germinal center formation (GO:0002634)2.42610343
131cell communication by electrical coupling (GO:0010644)2.40708757
132neuromuscular process controlling balance (GO:0050885)2.39896545
133positive regulation of neurotransmitter transport (GO:0051590)2.39228382
134positive regulation of neurotransmitter secretion (GO:0001956)2.38605362
135calcium ion-dependent exocytosis (GO:0017156)2.37655306
136neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.37195232
137response to auditory stimulus (GO:0010996)2.37030239
138regulation of vesicle fusion (GO:0031338)2.34002077
139response to pheromone (GO:0019236)2.33379092
140synapse organization (GO:0050808)2.32830390
141negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.32804469
142positive regulation of synaptic transmission (GO:0050806)2.32457969
143detection of other organism (GO:0098543)2.32086119
144cellular response to interleukin-15 (GO:0071350)2.30508145
145potassium ion import (GO:0010107)2.29191248
146neuromuscular process controlling posture (GO:0050884)2.29051394
147neuronal ion channel clustering (GO:0045161)2.28706809
148regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.28690525
149antigen receptor-mediated signaling pathway (GO:0050851)2.28480864
150cell differentiation in hindbrain (GO:0021533)2.28342379
151macrophage activation involved in immune response (GO:0002281)2.28282369
152detection of bacterium (GO:0016045)2.28117525
153regulation of dendritic spine development (GO:0060998)2.28091595
154negative regulation of leukocyte mediated immunity (GO:0002704)2.26377033
155positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.24882772
156regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.24328603
157tolerance induction (GO:0002507)2.24015946
158regulation of histone H3-K27 methylation (GO:0061085)2.23105648
159phosphatidylinositol dephosphorylation (GO:0046856)2.22658355
160regulation of alpha-beta T cell proliferation (GO:0046640)2.21714261
161interferon-gamma-mediated signaling pathway (GO:0060333)2.19750914
162phosphatidylinositol phosphorylation (GO:0046854)2.17766949
163JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.15423809
164mature B cell differentiation (GO:0002335)2.15298515
165negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.14769575
166negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.14697035
167phospholipid dephosphorylation (GO:0046839)2.14428989
168positive regulation of cellular amide metabolic process (GO:0034250)2.14324553
169regulation of beta-amyloid formation (GO:1902003)2.13878144
170regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.13225849
171positive regulation by symbiont of host defense response (GO:0052509)2.12340875
172modulation by symbiont of host defense response (GO:0052031)2.12340875
173modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.12340875
174modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.12340875
175positive regulation by organism of defense response of other organism involved in symbiotic interact2.12340875
176modulation by symbiont of host immune response (GO:0052553)2.12340875
177Rap protein signal transduction (GO:0032486)2.11517458
178negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.11360688
179growth hormone receptor signaling pathway (GO:0060396)2.10566961
180positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.10457475
181negative regulation of glycoprotein biosynthetic process (GO:0010561)2.10027387
182negative regulation of humoral immune response (GO:0002921)2.08916268
183microglial cell activation (GO:0001774)2.08327775
184regulation of inositol phosphate biosynthetic process (GO:0010919)2.08143915
185negative regulation of bone resorption (GO:0045779)2.06994680
186positive regulation of fibroblast migration (GO:0010763)2.06182781
187histone lysine demethylation (GO:0070076)2.04762588
188activated T cell proliferation (GO:0050798)2.04659890
189Golgi to endosome transport (GO:0006895)2.04186260
190peptidyl-tyrosine autophosphorylation (GO:0038083)2.03089572
191response to epinephrine (GO:0071871)2.02615098
192macroautophagy (GO:0016236)2.01979692
193lipid phosphorylation (GO:0046834)2.01464697
194regulation of platelet aggregation (GO:0090330)2.01300755
195regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.00960543
196response to host immune response (GO:0052572)2.00785844
197response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.00785844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.36334751
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.05072731
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.50376054
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47902905
5GBX2_23144817_ChIP-Seq_PC3_Human3.22194900
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51419235
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50770305
8RUNX_20019798_ChIP-Seq_JUKART_Human2.48240252
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41274468
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37493431
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36316872
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23749428
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23749428
14SCL_19346495_ChIP-Seq_HPC-7_Human2.22390675
15DROSHA_22980978_ChIP-Seq_HELA_Human2.19725363
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15027694
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14433770
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09883453
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08598248
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08317645
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07460751
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06556850
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05017400
24* EZH2_27304074_Chip-Seq_ESCs_Mouse2.02574076
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92572736
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92041445
27REST_21632747_ChIP-Seq_MESCs_Mouse1.91717615
28* EED_16625203_ChIP-ChIP_MESCs_Mouse1.90735253
29TAF15_26573619_Chip-Seq_HEK293_Human1.89734234
30* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85040650
31* RNF2_27304074_Chip-Seq_ESCs_Mouse1.84162924
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84011667
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.83354380
34GATA1_22025678_ChIP-Seq_K562_Human1.82758728
35AR_21572438_ChIP-Seq_LNCaP_Human1.78515841
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.74269375
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74016525
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70511133
39VDR_24787735_ChIP-Seq_THP-1_Human1.70160636
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69143010
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68693035
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.64585289
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.61795057
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60654524
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59595903
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59446340
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56724876
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.55711587
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.54883267
50* MYB_26560356_Chip-Seq_TH2_Human1.54546101
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52080688
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51706932
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.49667351
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.48221480
55SPI1_23127762_ChIP-Seq_K562_Human1.47871462
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47150250
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43209712
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.43041469
59* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42548731
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41033042
61GATA1_19941826_ChIP-Seq_K562_Human1.40621220
62* P300_19829295_ChIP-Seq_ESCs_Human1.39373730
63VDR_24763502_ChIP-Seq_THP-1_Human1.39291973
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38473641
65GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38389640
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37836372
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37197222
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35748212
69TCF7_22412390_ChIP-Seq_EML_Mouse1.33825516
70* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32594617
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30477634
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.29709628
73* STAT3_23295773_ChIP-Seq_U87_Human1.27741795
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27198647
75* GATA3_27048872_Chip-Seq_THYMUS_Human1.27198543
76AR_25329375_ChIP-Seq_VCAP_Human1.26776777
77GATA2_19941826_ChIP-Seq_K562_Human1.26536994
78* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26126637
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.25954922
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25636898
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25541644
82* MYB_26560356_Chip-Seq_TH1_Human1.25416687
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.24557423
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.24063058
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22000526
86* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21048790
87* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20451059
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20279130
89* CBX2_27304074_Chip-Seq_ESCs_Mouse1.20123312
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19120035
91AHR_22903824_ChIP-Seq_MCF-7_Human1.17623983
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17579277
93IGF1R_20145208_ChIP-Seq_DFB_Human1.17158182
94BP1_19119308_ChIP-ChIP_Hs578T_Human1.16662734
95* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16373487
96* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15322153
97AR_19668381_ChIP-Seq_PC3_Human1.15276034
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14643329
99ZNF274_21170338_ChIP-Seq_K562_Hela1.14290335
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14008087
101* TCF4_23295773_ChIP-Seq_U87_Human1.13648336
102IRF8_21731497_ChIP-ChIP_J774_Mouse1.12739901
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12443829
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12372376
105MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12085552
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11684338
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11111915
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10562493
109* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10360663
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08258484
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06699386
112BCAT_22108803_ChIP-Seq_LS180_Human1.06198404
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.05905543
114MAF_26560356_Chip-Seq_TH1_Human1.05665220
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05664135
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.05372383
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.04097340
118TP53_16413492_ChIP-PET_HCT116_Human1.04012183
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03578932
120FOXO3_23340844_ChIP-Seq_DLD1_Human1.03050983
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01974286
122RUNX2_22187159_ChIP-Seq_PCA_Human1.00279421
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00177641
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.99851811
125* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99674693
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99400342
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99107224
128MYC_22102868_ChIP-Seq_BL_Human0.98944390
129RNF2_27304074_Chip-Seq_NSC_Mouse0.98424742
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98187483
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.97824926
132RUNX1_22412390_ChIP-Seq_EML_Mouse0.97668853
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.96659830
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.95837837
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.95489915
136* KDM2B_26808549_Chip-Seq_DND41_Human0.95417768
137UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94968190
138* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94743219
139BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94310577
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94256437
141ER_23166858_ChIP-Seq_MCF-7_Human0.93815633
142TP53_18474530_ChIP-ChIP_U2OS_Human0.93178908
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92819997
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92450042
145* SMRT_27268052_Chip-Seq_Bcells_Human0.92330130
146* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92240288
147KDM2B_26808549_Chip-Seq_REH_Human0.91817744
148* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91686695
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91251330
150RXR_22108803_ChIP-Seq_LS180_Human0.90318008
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.90098422
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89951361
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89615375
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89615375
155GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89503709
156* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88876892
157* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88804220
158RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88145854
159PU_27001747_Chip-Seq_BMDM_Mouse0.86155857
160* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85312543
161TBX20_22080862_ChIP-Seq_HEART_Mouse0.85275423
162TBX20_22328084_ChIP-Seq_HEART_Mouse0.85275423
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84031235
164VDR_21846776_ChIP-Seq_THP-1_Human0.83682596
165NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83184352
166NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83184352
167* GATA3_26560356_Chip-Seq_TH2_Human0.83143831
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83015952
169* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82327658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.10292497
2MP0003880_abnormal_central_pattern3.91359722
3MP0003635_abnormal_synaptic_transmissio3.61569067
4MP0004270_analgesia2.99032640
5MP0009745_abnormal_behavioral_response2.95165033
6MP0009046_muscle_twitch2.89974160
7MP0002063_abnormal_learning/memory/cond2.76968785
8MP0003303_peritoneal_inflammation2.69124697
9MP0003763_abnormal_thymus_physiology2.65944945
10MP0002064_seizures2.64632255
11MP0009780_abnormal_chondrocyte_physiolo2.59998015
12MP0005423_abnormal_somatic_nervous2.59668152
13MP0001968_abnormal_touch/_nociception2.58959178
14MP0002166_altered_tumor_susceptibility2.53575212
15MP0001835_abnormal_antigen_presentation2.52043761
16MP0001486_abnormal_startle_reflex2.50013596
17MP0002572_abnormal_emotion/affect_behav2.48937337
18MP0002009_preneoplasia2.47135045
19MP0000685_abnormal_immune_system2.44475404
20MP0003300_gastrointestinal_ulcer2.32563826
21MP0002396_abnormal_hematopoietic_system2.25731047
22MP0002272_abnormal_nervous_system2.24998479
23MP0001501_abnormal_sleep_pattern2.21934282
24MP0002734_abnormal_mechanical_nocicepti2.17769384
25MP0001800_abnormal_humoral_immune2.13777750
26MP0003724_increased_susceptibility_to2.06070094
27MP0001790_abnormal_immune_system2.06065129
28MP0005387_immune_system_phenotype2.06065129
29MP0003172_abnormal_lysosome_physiology2.00887169
30MP0005646_abnormal_pituitary_gland1.96850048
31MP0002822_catalepsy1.89054620
32MP0005464_abnormal_platelet_physiology1.88079878
33MP0002736_abnormal_nociception_after1.87996104
34MP0003436_decreased_susceptibility_to1.83238202
35MP0000569_abnormal_digit_pigmentation1.82086530
36MP0005000_abnormal_immune_tolerance1.81726058
37MP0001440_abnormal_grooming_behavior1.80726227
38MP0002067_abnormal_sensory_capabilities1.78984389
39MP0008569_lethality_at_weaning1.77931576
40MP0002735_abnormal_chemical_nociception1.74988036
41MP0002909_abnormal_adrenal_gland1.74882250
42MP0005645_abnormal_hypothalamus_physiol1.70595218
43MP0003183_abnormal_peptide_metabolism1.70025465
44MP0002557_abnormal_social/conspecific_i1.65975811
45MP0002723_abnormal_immune_serum1.61846015
46MP0001851_eye_inflammation1.61443906
47MP0002420_abnormal_adaptive_immunity1.61045077
48MP0001984_abnormal_olfaction1.59075862
49MP0002419_abnormal_innate_immunity1.57772509
50MP0002733_abnormal_thermal_nociception1.57765845
51MP0006276_abnormal_autonomic_nervous1.56925518
52MP0010234_abnormal_vibrissa_follicle1.56347299
53MP0001819_abnormal_immune_cell1.56321123
54MP0005671_abnormal_response_to1.56192292
55MP0002452_abnormal_antigen_presenting1.54534310
56MP0003329_amyloid_beta_deposits1.53683191
57MP0001970_abnormal_pain_threshold1.52620661
58MP0000778_abnormal_nervous_system1.50943826
59MP0005551_abnormal_eye_electrophysiolog1.50198855
60MP0004808_abnormal_hematopoietic_stem1.49522684
61MP0004885_abnormal_endolymph1.48778576
62MP0001502_abnormal_circadian_rhythm1.47221445
63MP0002398_abnormal_bone_marrow1.47116662
64MP0003879_abnormal_hair_cell1.46978526
65MP0005310_abnormal_salivary_gland1.41981146
66MP0003633_abnormal_nervous_system1.41534893
67MP0005386_behavior/neurological_phenoty1.41333137
68MP0004924_abnormal_behavior1.41333137
69MP0002184_abnormal_innervation1.41000036
70MP0005025_abnormal_response_to1.40740638
71MP0003787_abnormal_imprinting1.40029542
72MP0002006_tumorigenesis1.38408750
73MP0000465_gastrointestinal_hemorrhage1.36816813
74MP0005409_darkened_coat_color1.33710725
75MP0001958_emphysema1.29628720
76MP0004947_skin_inflammation1.28887394
77MP0000716_abnormal_immune_system1.28825685
78MP0004811_abnormal_neuron_physiology1.26097600
79MP0003091_abnormal_cell_migration1.25521834
80MP0003828_pulmonary_edema1.22916329
81MP0003656_abnormal_erythrocyte_physiolo1.21904785
82MP0002998_abnormal_bone_remodeling1.21019630
83MP0002139_abnormal_hepatobiliary_system1.20582593
84MP0002405_respiratory_system_inflammati1.19842960
85MP0010155_abnormal_intestine_physiology1.19064430
86MP0000955_abnormal_spinal_cord1.17127133
87MP0008961_abnormal_basal_metabolism1.17120156
88MP0008057_abnormal_DNA_replication1.16271993
89MP0000703_abnormal_thymus_morphology1.15945317
90MP0002837_dystrophic_cardiac_calcinosis1.15760810
91MP0005365_abnormal_bile_salt1.15279587
92MP0002066_abnormal_motor_capabilities/c1.15117034
93MP0002882_abnormal_neuron_morphology1.14504137
94MP0010386_abnormal_urinary_bladder1.14380787
95MP0000015_abnormal_ear_pigmentation1.13940261
96MP0003122_maternal_imprinting1.13143267
97MP0003866_abnormal_defecation1.12462889
98MP0004036_abnormal_muscle_relaxation1.12156608
99MP0004145_abnormal_muscle_electrophysio1.11951664
100MP0005535_abnormal_body_temperature1.10321795
101MP0003631_nervous_system_phenotype1.09678534
102MP0004510_myositis1.09496671
103MP0002876_abnormal_thyroid_physiology1.09424413
104MP0002971_abnormal_brown_adipose1.09328609
105MP0000689_abnormal_spleen_morphology1.09319618
106MP0010368_abnormal_lymphatic_system1.07839376
107MP0001545_abnormal_hematopoietic_system1.07515781
108MP0005397_hematopoietic_system_phenotyp1.07515781
109MP0008875_abnormal_xenobiotic_pharmacok1.07404467
110MP0004381_abnormal_hair_follicle1.04188147
111MP0004130_abnormal_muscle_cell1.03667566
112MP0002722_abnormal_immune_system1.02804587
113MP0000013_abnormal_adipose_tissue1.02633241
114MP0008874_decreased_physiological_sensi1.01964081
115MP0004883_abnormal_blood_vessel1.01896679
116MP0004858_abnormal_nervous_system1.01733972
117MP0002090_abnormal_vision0.99522985
118MP0005275_abnormal_skin_tensile0.98628609
119MP0001188_hyperpigmentation0.98587450
120MP0004085_abnormal_heartbeat0.97678286
121MP0000751_myopathy0.97678020
122MP0010352_gastrointestinal_tract_polyps0.97580789
123MP0005085_abnormal_gallbladder_physiolo0.95205747
124MP0001177_atelectasis0.94401700
125MP0005360_urolithiasis0.94349738
126MP0002069_abnormal_eating/drinking_beha0.94124054
127MP0003279_aneurysm0.93398003
128MP0003690_abnormal_glial_cell0.93039532
129MP0006082_CNS_inflammation0.92734485
130MP0002429_abnormal_blood_cell0.92396230
131MP0002168_other_aberrant_phenotype0.92107655
132MP0002229_neurodegeneration0.92062705
133MP0001533_abnormal_skeleton_physiology0.91070301
134MP0001845_abnormal_inflammatory_respons0.89455239
135MP0005375_adipose_tissue_phenotype0.88181474
136MP0005166_decreased_susceptibility_to0.88066200
137MP0002693_abnormal_pancreas_physiology0.87133883
138MP0004742_abnormal_vestibular_system0.86321249
139MP0009115_abnormal_fat_cell0.86293692
140MP0005666_abnormal_adipose_tissue0.86154998
141MP0002138_abnormal_hepatobiliary_system0.86133220
142MP0008872_abnormal_physiological_respon0.85469859
143MP0000249_abnormal_blood_vessel0.85456857
144MP0004142_abnormal_muscle_tone0.85269927
145MP0003868_abnormal_feces_composition0.84095836
146MP0005410_abnormal_fertilization0.82338817
147MP0002148_abnormal_hypersensitivity_rea0.82323648
148MP0000631_abnormal_neuroendocrine_gland0.81871934
149MP0002152_abnormal_brain_morphology0.81614569
150MP0003045_fibrosis0.81230727
151MP0009785_altered_susceptibility_to0.80683534
152MP0004043_abnormal_pH_regulation0.80681334
153MP0005167_abnormal_blood-brain_barrier0.79889940
154MP0001905_abnormal_dopamine_level0.79683351
155MP0003252_abnormal_bile_duct0.78406844
156MP0004484_altered_response_of0.75474880
157MP0005187_abnormal_penis_morphology0.74486860
158MP0004215_abnormal_myocardial_fiber0.73418777
159MP0000604_amyloidosis0.73333513
160MP0002638_abnormal_pupillary_reflex0.73082577
161MP0010329_abnormal_lipoprotein_level0.72394338
162MP0000003_abnormal_adipose_tissue0.72333528
163MP0000920_abnormal_myelination0.71755818
164MP0005174_abnormal_tail_pigmentation0.70563606
165MP0001963_abnormal_hearing_physiology0.69544789
166MP0001299_abnormal_eye_distance/0.66713632
167MP0003632_abnormal_nervous_system0.65205250
168MP0001765_abnormal_ion_homeostasis0.64914706
169MP0000639_abnormal_adrenal_gland0.64738283
170MP0003634_abnormal_glial_cell0.62754817
171MP0001664_abnormal_digestion0.62005952
172MP0003075_altered_response_to0.61679819
173MP0000230_abnormal_systemic_arterial0.60859606

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.88791239
2Focal seizures (HP:0007359)4.45833375
3Myokymia (HP:0002411)4.36306575
4Progressive cerebellar ataxia (HP:0002073)4.14311162
5Epileptic encephalopathy (HP:0200134)4.13958383
6Visual hallucinations (HP:0002367)4.12839607
7Febrile seizures (HP:0002373)3.98511908
8Action tremor (HP:0002345)3.62169768
9Atonic seizures (HP:0010819)3.57077542
10Hyperventilation (HP:0002883)3.48810201
11Genetic anticipation (HP:0003743)3.37654312
12Eczematoid dermatitis (HP:0000976)3.31206019
13Absence seizures (HP:0002121)3.23762833
14Gaze-evoked nystagmus (HP:0000640)3.12973733
15Broad-based gait (HP:0002136)3.08949034
16Generalized tonic-clonic seizures (HP:0002069)3.05839416
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.03158585
18Colitis (HP:0002583)2.90413866
19Dysdiadochokinesis (HP:0002075)2.84164189
20Agammaglobulinemia (HP:0004432)2.83237971
21Drooling (HP:0002307)2.81872103
22Excessive salivation (HP:0003781)2.81872103
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.81060488
24Absent/shortened dynein arms (HP:0200106)2.81060488
25Dialeptic seizures (HP:0011146)2.78667171
26Prolonged bleeding time (HP:0003010)2.70786169
27Poor eye contact (HP:0000817)2.68995479
28Spontaneous hematomas (HP:0007420)2.67694366
29Abnormality of the fingertips (HP:0001211)2.67132764
30Postural instability (HP:0002172)2.66806544
31Supranuclear gaze palsy (HP:0000605)2.64913454
32Anxiety (HP:0000739)2.62431792
33Truncal ataxia (HP:0002078)2.61393532
34Abnormal social behavior (HP:0012433)2.60777406
35Impaired social interactions (HP:0000735)2.60777406
36Agitation (HP:0000713)2.60236157
37Depression (HP:0000716)2.58647952
38Recurrent fungal infections (HP:0002841)2.58479279
39Panhypogammaglobulinemia (HP:0003139)2.58019137
40Hemiplegia (HP:0002301)2.57607183
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57302658
42Dysmetria (HP:0001310)2.56101129
43Increased IgE level (HP:0003212)2.53293477
44Impaired vibration sensation in the lower limbs (HP:0002166)2.52990578
45Scanning speech (HP:0002168)2.51548258
46Urinary bladder sphincter dysfunction (HP:0002839)2.50882942
47Recurrent viral infections (HP:0004429)2.50860896
48Obstructive sleep apnea (HP:0002870)2.48219437
49Chronic mucocutaneous candidiasis (HP:0002728)2.47803152
50Recurrent cutaneous fungal infections (HP:0011370)2.47803152
51Ankle clonus (HP:0011448)2.46778528
52Inflammation of the large intestine (HP:0002037)2.46647708
53Abnormal eating behavior (HP:0100738)2.46551917
54Dysmetric saccades (HP:0000641)2.45036279
55Gastrointestinal stroma tumor (HP:0100723)2.44227545
56Papilledema (HP:0001085)2.43433708
57Recurrent bacterial skin infections (HP:0005406)2.42608308
58Hemiparesis (HP:0001269)2.39648178
59Neurofibrillary tangles (HP:0002185)2.35932712
60Status epilepticus (HP:0002133)2.34485157
61Recurrent bronchitis (HP:0002837)2.34097732
62Torticollis (HP:0000473)2.33159463
63Viral hepatitis (HP:0006562)2.32982508
64Mutism (HP:0002300)2.31195820
65Hyperkalemia (HP:0002153)2.31152460
66Cellulitis (HP:0100658)2.30826004
67Gastrointestinal inflammation (HP:0004386)2.30309118
68Intention tremor (HP:0002080)2.27447011
69Recurrent abscess formation (HP:0002722)2.26623758
70Epileptiform EEG discharges (HP:0011182)2.26158623
71Meningitis (HP:0001287)2.26019028
72Increased CSF protein (HP:0002922)2.25520255
73Gingival bleeding (HP:0000225)2.25208755
74Exercise-induced myalgia (HP:0003738)2.23903923
75Blue irides (HP:0000635)2.20147386
76EEG with generalized epileptiform discharges (HP:0011198)2.19717692
77Vasculitis (HP:0002633)2.19661625
78Macroorchidism (HP:0000053)2.19183384
79Impaired smooth pursuit (HP:0007772)2.17886543
80Gingivitis (HP:0000230)2.14193923
81Focal dystonia (HP:0004373)2.11971342
82Recurrent skin infections (HP:0001581)2.11453818
83Absent speech (HP:0001344)2.10102124
84Amblyopia (HP:0000646)2.09138707
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08272650
86Autoimmune hemolytic anemia (HP:0001890)2.07599257
87Stereotypic behavior (HP:0000733)2.07520262
88Stomatitis (HP:0010280)2.07279262
89Epistaxis (HP:0000421)2.05499014
90Impaired vibratory sensation (HP:0002495)2.05010626
91Hypsarrhythmia (HP:0002521)2.03775896
92Chest pain (HP:0100749)2.02119040
93Abnormality of ocular smooth pursuit (HP:0000617)2.01993753
94Diplopia (HP:0000651)2.01891749
95Abnormality of binocular vision (HP:0011514)2.01891749
96Progressive inability to walk (HP:0002505)2.01209974
97Osteomyelitis (HP:0002754)2.00557411
98Abnormality of the lower motor neuron (HP:0002366)2.00361041
99Slow saccadic eye movements (HP:0000514)1.99296217
100T lymphocytopenia (HP:0005403)1.98355903
101Hematochezia (HP:0002573)1.97314473
102Cerebral inclusion bodies (HP:0100314)1.96483375
103Elevated erythrocyte sedimentation rate (HP:0003565)1.95908907
104Abnormality of the corticospinal tract (HP:0002492)1.94341398
105Gastrointestinal infarctions (HP:0005244)1.93835040
106Recurrent sinusitis (HP:0011108)1.93486299
107Spastic gait (HP:0002064)1.93037892
108Dysostosis multiplex (HP:0000943)1.91878148
109Myositis (HP:0100614)1.91336483
110Polyphagia (HP:0002591)1.91108677
111Abnormality of T cell number (HP:0011839)1.90996858
112Craniofacial dystonia (HP:0012179)1.89925838
113Papilloma (HP:0012740)1.89919017
114Verrucae (HP:0200043)1.89919017
115Aortic aneurysm (HP:0004942)1.89734475
116Fair hair (HP:0002286)1.89367917
117Asymmetric septal hypertrophy (HP:0001670)1.88387553
118Chronic diarrhea (HP:0002028)1.88329529
119Acute myeloid leukemia (HP:0004808)1.88080823
120Urinary urgency (HP:0000012)1.87641138
121Congenital stationary night blindness (HP:0007642)1.87304702
122Abnormality of saccadic eye movements (HP:0000570)1.86784180
123Bradykinesia (HP:0002067)1.86425435
124Abnormality of salivation (HP:0100755)1.86274940
125Abnormality of T cell physiology (HP:0011840)1.86074192
126Interstitial pulmonary disease (HP:0006530)1.85214656
127Hyporeflexia of lower limbs (HP:0002600)1.84151698
128Central scotoma (HP:0000603)1.84011409
129Urinary glycosaminoglycan excretion (HP:0003541)1.83531105
130Mucopolysacchariduria (HP:0008155)1.83531105
131Abnormality of T cells (HP:0002843)1.83103422
132Fatigue (HP:0012378)1.82691799
133Spondylolisthesis (HP:0003302)1.82651151
134Generalized hypopigmentation of hair (HP:0011358)1.82642120
135Emphysema (HP:0002097)1.80309106
136Cranial hyperostosis (HP:0004437)1.79117050
137Restrictive lung disease (HP:0002091)1.78519727
138Glucose intolerance (HP:0000833)1.78052408
139Testicular neoplasm (HP:0010788)1.78026491
140Arterial thrombosis (HP:0004420)1.77969846
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77257418
142Lower limb muscle weakness (HP:0007340)1.74275147
143Prolonged QT interval (HP:0001657)1.73611440
144Ventricular fibrillation (HP:0001663)1.73238815
145Enlarged penis (HP:0000040)1.73181190
146Abnormal ciliary motility (HP:0012262)1.73129963
147Subacute progressive viral hepatitis (HP:0006572)1.73100257
148Growth hormone excess (HP:0000845)1.71603819
149Difficulty running (HP:0009046)1.71403506
150Pulmonary infiltrates (HP:0002113)1.69689568
151Abnormal respiratory motile cilium physiology (HP:0012261)1.69513924
152Abnormality of polysaccharide metabolism (HP:0011012)1.69422253
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69422253
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69422253
155Mediastinal lymphadenopathy (HP:0100721)1.69354488
156Insulin-resistant diabetes mellitus (HP:0000831)1.68708173
157Deep venous thrombosis (HP:0002625)1.68586929
158Craniofacial hyperostosis (HP:0004493)1.68188590
159Inability to walk (HP:0002540)1.67902322
160Gait ataxia (HP:0002066)1.67871378
161Abnormality of the periventricular white matter (HP:0002518)1.67258142
162Acute lymphatic leukemia (HP:0006721)1.66250324
163* Widely spaced teeth (HP:0000687)1.65963780
164Episodic fever (HP:0001954)1.65830039
165Exotropia (HP:0000577)1.65421948
166Increased variability in muscle fiber diameter (HP:0003557)1.64669170
167Postural tremor (HP:0002174)1.64498399
168Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62763454
169Abnormal EKG (HP:0003115)1.62444161
170Truncal obesity (HP:0001956)1.62289378
171Facial diplegia (HP:0001349)1.62205429
172Protruding tongue (HP:0010808)1.61462824
173Megalencephaly (HP:0001355)1.59688043
174Hypoventilation (HP:0002791)1.58091938
175Psychosis (HP:0000709)1.57912423
176Generalized myoclonic seizures (HP:0002123)1.57392485
177Neoplasm of the heart (HP:0100544)1.57092564
178Abnormality of macular pigmentation (HP:0008002)1.57070230
179Chronic hepatic failure (HP:0100626)1.55860317
180Increased circulating renin level (HP:0000848)1.55743210
181Insidious onset (HP:0003587)1.55417063
182Termporal pattern (HP:0011008)1.55417063
183Clonus (HP:0002169)1.54416772
184Ketoacidosis (HP:0001993)1.54392108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.35282353
2EPHA43.01715946
3MAP3K42.84480480
4MARK12.63077391
5MAP2K72.47255614
6MAP3K92.46052639
7TRPM72.26784084
8MAP4K12.22685285
9DAPK22.18844583
10MAP2K42.17331003
11FGFR32.14990045
12PRKD32.00026061
13CASK1.97837631
14TNIK1.97365852
15NTRK21.95630484
16MINK11.89826972
17STK381.75337400
18CDK121.72512887
19JAK11.69101143
20PAK61.67075732
21MAP3K121.62817831
22MAP3K131.54872369
23TEC1.53418057
24MAP3K141.52187165
25CAMK1G1.50621851
26BMPR21.50612085
27SYK1.46330687
28BTK1.45710927
29BLK1.44618652
30TYK21.42328665
31NTRK11.41468265
32KIT1.39040703
33SGK21.39030077
34MAPK71.35321131
35INSRR1.33808223
36ITK1.33154761
37MAPK131.33036877
38FGFR21.32432918
39SGK4941.32287556
40SGK2231.32287556
41SIK21.31757666
42CAMKK11.31610094
43MAP2K31.30566437
44PIK3CG1.29304552
45SGK31.22883992
46HIPK21.22205663
47IKBKE1.21038439
48HCK1.19995835
49KSR21.18769203
50CDK51.18429353
51EEF2K1.18298654
52WNK11.13088292
53ZAP701.12528145
54PRKCH1.12447359
55RIPK11.09132951
56CAMK11.08372003
57JAK31.07050006
58RIPK41.06844858
59NLK1.05014903
60MARK21.04125249
61RET1.01121478
62OXSR11.01074676
63WNK41.00815408
64TRIB31.00136600
65PHKG20.99078676
66PHKG10.99078676
67PINK10.97302036
68BRD40.96529637
69CAMKK20.93641465
70MAP3K60.93556279
71TYRO30.91814818
72CSK0.91085467
73FES0.90784732
74STK110.90759662
75GRK50.89450622
76DAPK10.89125603
77CDK190.88819405
78CAMK2A0.88530292
79PRKCG0.87520042
80JAK20.87092429
81MAP3K70.86646538
82KSR10.86162728
83TAOK10.85223915
84TBK10.84921500
85PTK2B0.84514575
86TIE10.83248155
87NEK90.82640909
88IRAK10.82254150
89PLK20.81885651
90PAK30.81358609
91WNK30.81271871
92CAMK1D0.81042726
93MAP3K20.79761463
94SIK30.77742868
95SGK10.77279204
96PRPF4B0.76538980
97TXK0.75395679
98MAPK110.75224470
99LYN0.74369827
100LCK0.73893371
101TNK20.73370119
102PDK10.72852450
103FRK0.71630377
104CAMK40.71396738
105PNCK0.69988895
106FGFR40.69718799
107TAOK30.68280364
108PDPK10.67444138
109IRAK20.66440955
110PRKCQ0.66182566
111FER0.65464674
112DMPK0.65085706
113GRK60.64531426
114PRKCE0.63323285
115CSF1R0.62930964
116SIK10.61954647
117TTN0.61665981
118PRKCZ0.61396612
119AKT30.61292246
120PIK3CA0.59980025
121IKBKB0.59181977
122MAP3K10.58183813
123LATS20.58142330
124OBSCN0.57977801
125STK390.57918995
126PRKD20.56684481
127MAPK120.56351950
128DYRK1A0.55917506
129PKN10.53427986
130UHMK10.52780044
131CSNK1G20.52769558
132RPS6KA30.52474578
133YES10.52426078
134CDK60.51708661
135PRKAA20.51366566
136EPHA30.51271000
137PDGFRB0.51134330
138CDC42BPA0.50743108
139IRAK40.49907942
140LMTK20.49594434
141STK240.48345467
142MAPK150.47845546
143MAP3K30.47195242
144CAMK2B0.47123448
145MUSK0.46742766
146MAPKAPK50.44932884
147PDK30.44323852
148PDK40.44323852
149FYN0.43697465
150EPHB10.43616605
151MAPK100.43491217
152NEK60.43000219
153CHUK0.42706579
154MAPK40.42661972
155MAP2K60.42527847
156ARAF0.42487964

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01732352
2GABAergic synapse_Homo sapiens_hsa047272.26762487
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22094636
4Circadian entrainment_Homo sapiens_hsa047132.21145953
5Synaptic vesicle cycle_Homo sapiens_hsa047212.19911975
6B cell receptor signaling pathway_Homo sapiens_hsa046622.15869217
7Glutamatergic synapse_Homo sapiens_hsa047242.10658289
8Morphine addiction_Homo sapiens_hsa050322.08892318
9Olfactory transduction_Homo sapiens_hsa047402.03264274
10Long-term potentiation_Homo sapiens_hsa047201.95789120
11Nitrogen metabolism_Homo sapiens_hsa009101.94897559
12Amphetamine addiction_Homo sapiens_hsa050311.89817435
13Insulin secretion_Homo sapiens_hsa049111.84753828
14Salivary secretion_Homo sapiens_hsa049701.82772369
15Renin secretion_Homo sapiens_hsa049241.72046562
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71501991
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66092298
18Dopaminergic synapse_Homo sapiens_hsa047281.62002568
19Taste transduction_Homo sapiens_hsa047421.58281336
20Gastric acid secretion_Homo sapiens_hsa049711.57453608
21Cholinergic synapse_Homo sapiens_hsa047251.52575525
22T cell receptor signaling pathway_Homo sapiens_hsa046601.48781652
23Type I diabetes mellitus_Homo sapiens_hsa049401.48394575
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46585022
25Osteoclast differentiation_Homo sapiens_hsa043801.46181096
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.44325318
27Autoimmune thyroid disease_Homo sapiens_hsa053201.44293141
28Allograft rejection_Homo sapiens_hsa053301.44026610
29Platelet activation_Homo sapiens_hsa046111.42904994
30Leishmaniasis_Homo sapiens_hsa051401.42705453
31Cocaine addiction_Homo sapiens_hsa050301.39213391
32Graft-versus-host disease_Homo sapiens_hsa053321.37960497
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36365181
34Long-term depression_Homo sapiens_hsa047301.34825463
35Calcium signaling pathway_Homo sapiens_hsa040201.34440500
36Type II diabetes mellitus_Homo sapiens_hsa049301.34216336
37Acute myeloid leukemia_Homo sapiens_hsa052211.32467461
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30670818
39Oxytocin signaling pathway_Homo sapiens_hsa049211.29550883
40Serotonergic synapse_Homo sapiens_hsa047261.29402371
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28145030
42cAMP signaling pathway_Homo sapiens_hsa040241.24751889
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20877560
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20361822
45Non-small cell lung cancer_Homo sapiens_hsa052231.18733597
46Asthma_Homo sapiens_hsa053101.18297942
47Dorso-ventral axis formation_Homo sapiens_hsa043201.15397993
48Primary immunodeficiency_Homo sapiens_hsa053401.13326499
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12731095
50Phototransduction_Homo sapiens_hsa047441.10269669
51Staphylococcus aureus infection_Homo sapiens_hsa051501.10002426
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09786276
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08067227
54GnRH signaling pathway_Homo sapiens_hsa049121.07899813
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05691311
56Bile secretion_Homo sapiens_hsa049761.05565030
57Prolactin signaling pathway_Homo sapiens_hsa049171.04926430
58Toxoplasmosis_Homo sapiens_hsa051451.04618608
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04278307
60Tuberculosis_Homo sapiens_hsa051521.03973853
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03488875
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02551048
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00931061
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99460804
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99415790
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.99104870
67Estrogen signaling pathway_Homo sapiens_hsa049150.97955356
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.96999102
69Arginine biosynthesis_Homo sapiens_hsa002200.95570679
70Chemokine signaling pathway_Homo sapiens_hsa040620.94013349
71Chronic myeloid leukemia_Homo sapiens_hsa052200.93844269
72Gap junction_Homo sapiens_hsa045400.93356818
73Axon guidance_Homo sapiens_hsa043600.92319905
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.91120444
75Pancreatic cancer_Homo sapiens_hsa052120.90878429
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90769394
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90664867
78Butanoate metabolism_Homo sapiens_hsa006500.89908042
79Measles_Homo sapiens_hsa051620.89344202
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.89077913
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.88288957
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.86978090
83Influenza A_Homo sapiens_hsa051640.86269883
84FoxO signaling pathway_Homo sapiens_hsa040680.85435953
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83291233
86Circadian rhythm_Homo sapiens_hsa047100.82030429
87Hepatitis B_Homo sapiens_hsa051610.81590461
88Melanogenesis_Homo sapiens_hsa049160.80924629
89Pancreatic secretion_Homo sapiens_hsa049720.79961658
90Glioma_Homo sapiens_hsa052140.79410439
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79258435
92Glucagon signaling pathway_Homo sapiens_hsa049220.78901348
93Thyroid hormone synthesis_Homo sapiens_hsa049180.77714875
94Viral myocarditis_Homo sapiens_hsa054160.77040693
95Other glycan degradation_Homo sapiens_hsa005110.76873277
96Hematopoietic cell lineage_Homo sapiens_hsa046400.74604895
97TNF signaling pathway_Homo sapiens_hsa046680.73258472
98Ovarian steroidogenesis_Homo sapiens_hsa049130.71804463
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71630784
100ErbB signaling pathway_Homo sapiens_hsa040120.71144096
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70775049
102Choline metabolism in cancer_Homo sapiens_hsa052310.70215045
103Hepatitis C_Homo sapiens_hsa051600.69289965
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.68101680
105Dilated cardiomyopathy_Homo sapiens_hsa054140.67118827
106Collecting duct acid secretion_Homo sapiens_hsa049660.66317843
107Antigen processing and presentation_Homo sapiens_hsa046120.62659685
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61622401
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59862815
110Amoebiasis_Homo sapiens_hsa051460.59311348
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58893125
112Prostate cancer_Homo sapiens_hsa052150.58316462
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57496412
114MAPK signaling pathway_Homo sapiens_hsa040100.57073788
115Focal adhesion_Homo sapiens_hsa045100.54267848
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53292777
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53027864
118ABC transporters_Homo sapiens_hsa020100.50906545
119Ras signaling pathway_Homo sapiens_hsa040140.50122687
120Inositol phosphate metabolism_Homo sapiens_hsa005620.49855170
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49840016
122Rap1 signaling pathway_Homo sapiens_hsa040150.49185745
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48814032
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47737709
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46989954
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46786895
127PPAR signaling pathway_Homo sapiens_hsa033200.45995245
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42136713
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40542463
130Fatty acid biosynthesis_Homo sapiens_hsa000610.40352429
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39904355
132Insulin signaling pathway_Homo sapiens_hsa049100.39591741
133Wnt signaling pathway_Homo sapiens_hsa043100.39298366
134Glycerolipid metabolism_Homo sapiens_hsa005610.38899512
135Insulin resistance_Homo sapiens_hsa049310.37813114
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37529771
137Complement and coagulation cascades_Homo sapiens_hsa046100.37508628
138Endometrial cancer_Homo sapiens_hsa052130.37486474
139VEGF signaling pathway_Homo sapiens_hsa043700.36834221
140Renal cell carcinoma_Homo sapiens_hsa052110.36162451
141Tryptophan metabolism_Homo sapiens_hsa003800.35204226
142Fatty acid metabolism_Homo sapiens_hsa012120.35183290
143mTOR signaling pathway_Homo sapiens_hsa041500.34642750
144Cardiac muscle contraction_Homo sapiens_hsa042600.34478504
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.33419062
146Fatty acid degradation_Homo sapiens_hsa000710.33085206
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.32678453
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.32678193

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