SMARCA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.68947219
2regulation of histone H3-K9 methylation (GO:0051570)5.41955237
3negative regulation of histone methylation (GO:0031061)5.12816574
4V(D)J recombination (GO:0033151)5.04726589
5protein localization to kinetochore (GO:0034501)4.54082942
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.26446897
7sister chromatid segregation (GO:0000819)4.24589103
8* protein-DNA complex disassembly (GO:0032986)4.18153142
9* nucleosome disassembly (GO:0006337)4.18153142
10pre-miRNA processing (GO:0031054)4.14527740
11heterochromatin organization (GO:0070828)4.11846374
12mitotic sister chromatid cohesion (GO:0007064)4.08597925
13negative regulation of RNA splicing (GO:0033119)4.02273093
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.99080232
15protein localization to chromosome, centromeric region (GO:0071459)3.88003923
16chromatin assembly (GO:0031497)3.85892337
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.85166982
18mitotic sister chromatid segregation (GO:0000070)3.80822264
19positive regulation of gene expression, epigenetic (GO:0045815)3.76919637
20dosage compensation (GO:0007549)3.71146536
21mitotic chromosome condensation (GO:0007076)3.69358062
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.68428082
23negative regulation of mRNA processing (GO:0050686)3.68149590
24cell migration in hindbrain (GO:0021535)3.64638097
25DNA duplex unwinding (GO:0032508)3.61769532
26nuclear pore complex assembly (GO:0051292)3.61303199
27DNA geometric change (GO:0032392)3.57215819
28DNA topological change (GO:0006265)3.54531442
29peptidyl-arginine omega-N-methylation (GO:0035247)3.52112734
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.51322602
31paraxial mesoderm development (GO:0048339)3.47721240
32nuclear pore organization (GO:0006999)3.45106979
33regulation of NFAT protein import into nucleus (GO:0051532)3.40365938
34negative regulation of mRNA metabolic process (GO:1903312)3.40359082
35alternative mRNA splicing, via spliceosome (GO:0000380)3.38237769
36convergent extension (GO:0060026)3.35763869
37ribosomal small subunit biogenesis (GO:0042274)3.33631501
38positive regulation of histone H3-K4 methylation (GO:0051571)3.33185785
39regulation of histone H3-K4 methylation (GO:0051569)3.32532059
40positive regulation of chromosome segregation (GO:0051984)3.32287949
41histone arginine methylation (GO:0034969)3.30029977
42positive regulation of histone deacetylation (GO:0031065)3.28070702
43mitotic nuclear envelope disassembly (GO:0007077)3.27840593
44protein localization to chromosome (GO:0034502)3.27601034
45regulation of sister chromatid cohesion (GO:0007063)3.25665598
46translesion synthesis (GO:0019985)3.25387746
47cellular hyperosmotic response (GO:0071474)3.21087260
48DNA replication-dependent nucleosome assembly (GO:0006335)3.20760280
49DNA replication-dependent nucleosome organization (GO:0034723)3.20760280
50regulation of histone methylation (GO:0031060)3.19705682
51regulation of RNA export from nucleus (GO:0046831)3.17526784
52DNA strand elongation involved in DNA replication (GO:0006271)3.15730043
53chromatin assembly or disassembly (GO:0006333)3.13245852
54positive regulation of RNA splicing (GO:0033120)3.12369269
55negative regulation of histone modification (GO:0031057)3.10175471
56regulation of translational fidelity (GO:0006450)3.09639401
57membrane disassembly (GO:0030397)3.09414296
58nuclear envelope disassembly (GO:0051081)3.09414296
59spliceosomal tri-snRNP complex assembly (GO:0000244)3.07701068
60establishment of integrated proviral latency (GO:0075713)3.07690445
61RNA stabilization (GO:0043489)3.07486786
62mRNA stabilization (GO:0048255)3.07486786
63glucocorticoid receptor signaling pathway (GO:0042921)3.07086021
64positive regulation of transcription regulatory region DNA binding (GO:2000679)3.06156413
65establishment of monopolar cell polarity (GO:0061162)3.05498525
66establishment or maintenance of monopolar cell polarity (GO:0061339)3.05498525
67mitochondrion transport along microtubule (GO:0047497)3.05320895
68establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05320895
69peptidyl-lysine dimethylation (GO:0018027)3.05210290
70regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04953405
71peptidyl-arginine methylation (GO:0018216)3.03847749
72peptidyl-arginine N-methylation (GO:0035246)3.03847749
73establishment of mitochondrion localization (GO:0051654)2.97250075
74* ATP-dependent chromatin remodeling (GO:0043044)2.97034513
75establishment of apical/basal cell polarity (GO:0035089)2.95451476
76positive regulation of B cell differentiation (GO:0045579)2.94935375
77DNA strand elongation (GO:0022616)2.94523161
78* negative regulation of gene expression, epigenetic (GO:0045814)2.94122149
79DNA conformation change (GO:0071103)2.91599880
80somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.91297412
81somatic cell DNA recombination (GO:0016444)2.91297412
82body morphogenesis (GO:0010171)2.91050544
83maturation of SSU-rRNA (GO:0030490)2.89157821
84regulation of DNA endoreduplication (GO:0032875)2.87128392
85negative regulation of chromatin modification (GO:1903309)2.85632927
86negative regulation of cell size (GO:0045792)2.84966377
87histone H4 acetylation (GO:0043967)2.84382047
88positive regulation of mitotic sister chromatid separation (GO:1901970)2.84208280
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.84208280
90positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84208280
91Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.83906527
92intracellular estrogen receptor signaling pathway (GO:0030520)2.82069725
93negative regulation of gene silencing (GO:0060969)2.81447481
94natural killer cell differentiation (GO:0001779)2.81299223
95germ cell migration (GO:0008354)2.78699491
96B cell receptor signaling pathway (GO:0050853)2.76944177
97chromosome condensation (GO:0030261)2.76570791
98regulation of chromatin binding (GO:0035561)2.75819486
99regulation of chromatin silencing (GO:0031935)2.75795419
100histone H4-K16 acetylation (GO:0043984)2.75314730
101mRNA splicing, via spliceosome (GO:0000398)2.74245248
102RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.74245248
103viral transcription (GO:0019083)2.73039737
104somatic diversification of immune receptors (GO:0002200)2.71889068
105L-serine transport (GO:0015825)2.71272490
106regulation of spindle organization (GO:0090224)2.69845066
107RNA splicing, via transesterification reactions (GO:0000375)2.69458618
108pore complex assembly (GO:0046931)2.69123652
109regulation of DNA damage checkpoint (GO:2000001)2.68470409
110embryonic body morphogenesis (GO:0010172)2.67915710
111* nucleosome organization (GO:0034728)2.67880801
112regulation of establishment of planar polarity (GO:0090175)2.67708228
113regulation of gene silencing (GO:0060968)2.67487022
114mitotic recombination (GO:0006312)2.67121539
115regulation of chromosome segregation (GO:0051983)2.66797071
116positive regulation of gamma-delta T cell activation (GO:0046645)2.65304043
117RNA localization (GO:0006403)2.64584153
118DNA replication initiation (GO:0006270)2.63827992
119histone H4-K8 acetylation (GO:0043982)2.62696231
120histone H4-K5 acetylation (GO:0043981)2.62696231
121* chromatin silencing (GO:0006342)2.61884552
122neural tube development (GO:0021915)2.61612789
123nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.61351548
124cell-cell junction maintenance (GO:0045217)2.61286828
125camera-type eye morphogenesis (GO:0048593)2.60436290
126base-excision repair (GO:0006284)2.60273688
127* gene silencing (GO:0016458)2.60040782
128regulation of telomere maintenance via telomerase (GO:0032210)2.59974755
129formation of translation preinitiation complex (GO:0001731)2.59610694
130regulation of gamma-delta T cell differentiation (GO:0045586)2.59555596
131semaphorin-plexin signaling pathway (GO:0071526)2.57389342
132establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.57368746
133regulation of nucleobase-containing compound transport (GO:0032239)2.56908491
134translational termination (GO:0006415)2.55899618
135notochord development (GO:0030903)2.54802535
136apoptotic process involved in morphogenesis (GO:0060561)2.46273476
137cochlea morphogenesis (GO:0090103)2.38841482
138protein complex localization (GO:0031503)2.38021496
139* protein complex disassembly (GO:0043241)2.37920989
140establishment of mitotic spindle localization (GO:0040001)2.37875289
141stress granule assembly (GO:0034063)2.37432736
142positive regulation of cell cycle checkpoint (GO:1901978)2.36037602
143L-serine metabolic process (GO:0006563)2.34558658
144establishment or maintenance of apical/basal cell polarity (GO:0035088)2.32585560
145establishment or maintenance of bipolar cell polarity (GO:0061245)2.32585560
146negative regulation of microtubule polymerization (GO:0031115)2.31626265
147positive regulation of cell cycle G2/M phase transition (GO:1902751)2.31305752
148positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.31305752
149establishment of spindle orientation (GO:0051294)2.31252868
150positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.30790885
151collecting duct development (GO:0072044)2.30438301
152pyrimidine nucleobase catabolic process (GO:0006208)2.30306078
153establishment of spindle localization (GO:0051293)2.28297024
154ribosomal small subunit assembly (GO:0000028)2.27808215
155regulation of stem cell maintenance (GO:2000036)2.27397665
156layer formation in cerebral cortex (GO:0021819)2.26586634
157translational elongation (GO:0006414)2.25818293
158spinal cord development (GO:0021510)2.24061675
159* macromolecular complex disassembly (GO:0032984)2.21899004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.39965850
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.23367429
3* MYC_22102868_ChIP-Seq_BL_Human4.45481757
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.58713240
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53375129
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.51123186
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.14696383
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.12098011
9* VDR_21846776_ChIP-Seq_THP-1_Human2.92590464
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.60556419
11CIITA_25753668_ChIP-Seq_RAJI_Human2.48379131
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42448717
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40467131
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.19015864
15* TP63_19390658_ChIP-ChIP_HaCaT_Human2.19002444
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18665223
17* KDM2B_26808549_Chip-Seq_DND41_Human2.09867538
18* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05882863
19* E2F1_21310950_ChIP-Seq_MCF-7_Human2.00842384
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92374446
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.90301409
22* MYC_18555785_ChIP-Seq_MESCs_Mouse1.89632031
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87496020
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86721174
25UTX_26944678_Chip-Seq_JUKART_Human1.86210726
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84205269
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75790041
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73996978
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71659596
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.68171078
31EZH2_22144423_ChIP-Seq_EOC_Human1.61752509
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.59178607
33XRN2_22483619_ChIP-Seq_HELA_Human1.57036935
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55471073
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55176764
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54627738
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53995335
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53927553
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53240281
40MAF_26560356_Chip-Seq_TH1_Human1.52919493
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.52162884
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47510747
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46662131
44ZNF263_19887448_ChIP-Seq_K562_Human1.46581067
45AR_21909140_ChIP-Seq_LNCAP_Human1.45823395
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45654531
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43753212
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43602086
49VDR_24763502_ChIP-Seq_THP-1_Human1.42513111
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.41136757
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38202057
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36454634
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35602066
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34728633
55* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33983517
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32077189
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.31621826
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30856170
59P68_20966046_ChIP-Seq_HELA_Human1.29206105
60* KDM5A_27292631_Chip-Seq_BREAST_Human1.28300951
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.27198031
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26103473
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25887413
64* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25312809
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21982370
66SCL_19346495_ChIP-Seq_HPC-7_Human1.21675536
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21671257
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21250720
69* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21203372
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14977382
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14929780
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14843474
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14667249
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14211772
75* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13147362
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12833285
77* CTCF_27219007_Chip-Seq_Bcells_Human1.12689027
78CHD1_26751641_Chip-Seq_LNCaP_Human1.12091820
79MYB_26560356_Chip-Seq_TH1_Human1.11986538
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11811332
81* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11529281
82MYB_26560356_Chip-Seq_TH2_Human1.11497175
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10897824
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10685843
85SMC4_20622854_ChIP-Seq_HELA_Human1.10467654
86* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09454762
87TP53_20018659_ChIP-ChIP_R1E_Mouse1.08915877
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08731109
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07644883
90MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07595975
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06635403
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.06137553
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.05200644
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04532690
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04466736
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04362250
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04362250
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04362250
99NCOR1_26117541_ChIP-Seq_K562_Human1.03980809
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03720080
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03296488
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03249134
103MAF_26560356_Chip-Seq_TH2_Human1.03127086
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02876222
105* RARB_27405468_Chip-Seq_BRAIN_Mouse1.02411029
106P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00571076
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00419479
108* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00232556
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99925009
110FOXP3_21729870_ChIP-Seq_TREG_Human0.99878546
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99743020
112KDM2B_26808549_Chip-Seq_K562_Human0.99138311
113NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99033455
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98491564
115LXR_22292898_ChIP-Seq_THP-1_Human0.97514067
116STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97034268
117ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96809842
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95076167
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94564981
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93230983
121HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89027144
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88482181
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88035995
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87309332
125CREB1_26743006_Chip-Seq_LNCaP_Human0.86325325
126* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86123025
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85509063
128TP53_22127205_ChIP-Seq_IMR90_Human0.84130703
129RUNX1_22412390_ChIP-Seq_EML_Mouse0.83963202
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83732775
131THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83655159
132RACK7_27058665_Chip-Seq_MCF-7_Human0.83184297
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82389437
134* TTF2_22483619_ChIP-Seq_HELA_Human0.82312533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.61159152
2MP0003111_abnormal_nucleus_morphology3.41719847
3MP0005076_abnormal_cell_differentiation3.12951337
4MP0009278_abnormal_bone_marrow3.11206734
5MP0003077_abnormal_cell_cycle2.89431061
6MP0000566_synostosis2.82095975
7MP0003693_abnormal_embryo_hatching2.71625201
8MP0002396_abnormal_hematopoietic_system2.65891865
9MP0004808_abnormal_hematopoietic_stem2.60030390
10MP0010352_gastrointestinal_tract_polyps2.54203794
11MP0004957_abnormal_blastocyst_morpholog2.44784996
12MP0008057_abnormal_DNA_replication2.32494361
13MP0001730_embryonic_growth_arrest2.29006395
14MP0006292_abnormal_olfactory_placode2.22030404
15MP0000350_abnormal_cell_proliferation2.16486667
16MP0002249_abnormal_larynx_morphology2.13412061
17MP0003705_abnormal_hypodermis_morpholog2.00412256
18MP0008007_abnormal_cellular_replicative1.98242436
19MP0003303_peritoneal_inflammation1.96541703
20MP0001849_ear_inflammation1.93846383
21MP0000778_abnormal_nervous_system1.92485791
22MP0008877_abnormal_DNA_methylation1.91889622
23MP0000537_abnormal_urethra_morphology1.90092798
24MP0006054_spinal_hemorrhage1.89744540
25MP0004197_abnormal_fetal_growth/weight/1.88490267
26MP0003121_genomic_imprinting1.85256470
27MP0003942_abnormal_urinary_system1.77321542
28MP0001672_abnormal_embryogenesis/_devel1.77170244
29MP0005380_embryogenesis_phenotype1.77170244
30MP0004859_abnormal_synaptic_plasticity1.76782989
31* MP0000703_abnormal_thymus_morphology1.76566471
32MP0008058_abnormal_DNA_repair1.76385732
33MP0000049_abnormal_middle_ear1.76283425
34MP0010307_abnormal_tumor_latency1.74644404
35MP0004858_abnormal_nervous_system1.72453380
36* MP0002085_abnormal_embryonic_tissue1.71877192
37MP0003984_embryonic_growth_retardation1.67883505
38MP0001697_abnormal_embryo_size1.66984145
39* MP0002084_abnormal_developmental_patter1.66548596
40MP0002088_abnormal_embryonic_growth/wei1.64502294
41MP0003300_gastrointestinal_ulcer1.61288661
42MP0009379_abnormal_foot_pigmentation1.59984502
43MP0004233_abnormal_muscle_weight1.55547858
44MP0003123_paternal_imprinting1.53076017
45MP0005257_abnormal_intraocular_pressure1.51125435
46MP0002089_abnormal_postnatal_growth/wei1.50599521
47* MP0002080_prenatal_lethality1.50244157
48MP0008961_abnormal_basal_metabolism1.48453996
49MP0003890_abnormal_embryonic-extraembry1.47504298
50MP0005409_darkened_coat_color1.47214938
51MP0000579_abnormal_nail_morphology1.46483171
52MP0002086_abnormal_extraembryonic_tissu1.45542311
53MP0003938_abnormal_ear_development1.45431317
54* MP0002398_abnormal_bone_marrow1.43823169
55MP0001545_abnormal_hematopoietic_system1.42313422
56MP0005397_hematopoietic_system_phenotyp1.42313422
57MP0002822_catalepsy1.41738382
58MP0002653_abnormal_ependyma_morphology1.41714510
59MP0003315_abnormal_perineum_morphology1.40687754
60MP0000733_abnormal_muscle_development1.39967268
61MP0003119_abnormal_digestive_system1.39279433
62MP0005423_abnormal_somatic_nervous1.39174835
63MP0000534_abnormal_ureter_morphology1.36927544
64MP0000490_abnormal_crypts_of1.36822426
65MP0000685_abnormal_immune_system1.36139014
66MP0008932_abnormal_embryonic_tissue1.33311596
67* MP0002019_abnormal_tumor_incidence1.31191650
68* MP0003937_abnormal_limbs/digits/tail_de1.30169149
69MP0010030_abnormal_orbit_morphology1.29172053
70MP0000955_abnormal_spinal_cord1.28126586
71MP0002116_abnormal_craniofacial_bone1.26142463
72MP0000313_abnormal_cell_death1.24768486
73MP0009672_abnormal_birth_weight1.23783337
74MP0000678_abnormal_parathyroid_gland1.23439138
75MP0003567_abnormal_fetal_cardiomyocyte1.23418007
76MP0002938_white_spotting1.22107383
77MP0003755_abnormal_palate_morphology1.21437435
78MP0000569_abnormal_digit_pigmentation1.21091468
79MP0002184_abnormal_innervation1.20667077
80* MP0003861_abnormal_nervous_system1.18645231
81* MP0002722_abnormal_immune_system1.18452691
82MP0001915_intracranial_hemorrhage1.18368511
83MP0001346_abnormal_lacrimal_gland1.17826715
84* MP0002152_abnormal_brain_morphology1.16653707
85MP0003787_abnormal_imprinting1.16035258
86MP0001299_abnormal_eye_distance/1.15784476
87MP0000428_abnormal_craniofacial_morphol1.15167463
88MP0009703_decreased_birth_body1.14508311
89MP0003115_abnormal_respiratory_system1.13031575
90MP0000689_abnormal_spleen_morphology1.12899847
91MP0003935_abnormal_craniofacial_develop1.11491137
92MP0002925_abnormal_cardiovascular_devel1.08848048
93MP0004133_heterotaxia1.08784244
94MP0001188_hyperpigmentation1.08023082
95MP0003566_abnormal_cell_adhesion1.07166681
96MP0001800_abnormal_humoral_immune1.07011305
97MP0002233_abnormal_nose_morphology1.01074492
98MP0004811_abnormal_neuron_physiology1.00748989
99MP0002166_altered_tumor_susceptibility0.99253566
100MP0002092_abnormal_eye_morphology0.96424856
101MP0009053_abnormal_anal_canal0.95487551
102MP0005187_abnormal_penis_morphology0.94524331
103MP0010234_abnormal_vibrissa_follicle0.94006155
104MP0008789_abnormal_olfactory_epithelium0.92623364
105MP0002114_abnormal_axial_skeleton0.92488885
106MP0001348_abnormal_lacrimal_gland0.92352959
107MP0004185_abnormal_adipocyte_glucose0.92219129
108MP0009250_abnormal_appendicular_skeleto0.91123305
109* MP0000716_abnormal_immune_system0.90167958
110MP0005623_abnormal_meninges_morphology0.89460628
111MP0000631_abnormal_neuroendocrine_gland0.89021555
112MP0002697_abnormal_eye_size0.88041179
113* MP0002429_abnormal_blood_cell0.87305499
114MP0000762_abnormal_tongue_morphology0.85630190
115MP0002882_abnormal_neuron_morphology0.85138908
116MP0005394_taste/olfaction_phenotype0.84769632
117MP0005499_abnormal_olfactory_system0.84769632
118MP0003763_abnormal_thymus_physiology0.84650532
119MP0001293_anophthalmia0.82138883
120MP0003122_maternal_imprinting0.82111230
121MP0000266_abnormal_heart_morphology0.80497629
122MP0005645_abnormal_hypothalamus_physiol0.80406284
123MP0000462_abnormal_digestive_system0.79872926
124MP0005621_abnormal_cell_physiology0.79783450
125MP0001879_abnormal_lymphatic_vessel0.79678725
126MP0002932_abnormal_joint_morphology0.77831461
127MP0003635_abnormal_synaptic_transmissio0.77690450
128MP0001286_abnormal_eye_development0.77636816
129* MP0001784_abnormal_fluid_regulation0.77398354
130* MP0008770_decreased_survivor_rate0.77195778
131MP0000432_abnormal_head_morphology0.77168190
132MP0002751_abnormal_autonomic_nervous0.76407696
133MP0010630_abnormal_cardiac_muscle0.76352176
134MP0001529_abnormal_vocalization0.75114854
135MP0003385_abnormal_body_wall0.74650802
136* MP0002081_perinatal_lethality0.72948866
137MP0002111_abnormal_tail_morphology0.72615256
138MP0000477_abnormal_intestine_morphology0.72187561
139MP0000003_abnormal_adipose_tissue0.71762332
140MP0003786_premature_aging0.70978288
141MP0002452_abnormal_antigen_presenting0.70772593
142MP0005384_cellular_phenotype0.69785134
143MP0003283_abnormal_digestive_organ0.64941312

Predicted human phenotypes

RankGene SetZ-score
1Verrucae (HP:0200043)4.40997998
2Papilloma (HP:0012740)4.40997998
3Agammaglobulinemia (HP:0004432)4.31303474
4Cellulitis (HP:0100658)4.26125264
5Hyperacusis (HP:0010780)3.91101199
6B lymphocytopenia (HP:0010976)3.76308014
7Abnormality of B cell number (HP:0010975)3.76308014
8Thyroiditis (HP:0100646)3.67413624
9Abnormality of the fingertips (HP:0001211)3.49642297
10High anterior hairline (HP:0009890)3.44859551
11Vertebral arch anomaly (HP:0008438)3.35744054
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.32847548
13Short 4th metacarpal (HP:0010044)3.32847548
14Volvulus (HP:0002580)3.25428726
15Increased nuchal translucency (HP:0010880)3.04033956
16Small epiphyses (HP:0010585)2.84854294
17Panhypogammaglobulinemia (HP:0003139)2.72428053
18Severe combined immunodeficiency (HP:0004430)2.70002736
19Abnormality of the aortic arch (HP:0012303)2.68659565
20Acute lymphatic leukemia (HP:0006721)2.66211874
21Ependymoma (HP:0002888)2.64886011
22Ulnar bowing (HP:0003031)2.61876880
23Renal duplication (HP:0000075)2.58842939
24Broad distal phalanx of finger (HP:0009836)2.54944199
25Combined immunodeficiency (HP:0005387)2.50541829
26Long palpebral fissure (HP:0000637)2.48282674
27Proximal placement of thumb (HP:0009623)2.46298561
28Deep palmar crease (HP:0006191)2.43433645
29Abnormality of the 4th metacarpal (HP:0010012)2.41354721
30Turricephaly (HP:0000262)2.41353611
31Cortical dysplasia (HP:0002539)2.40244451
32Reticulocytopenia (HP:0001896)2.35400454
33Deviation of the thumb (HP:0009603)2.34025694
34Astrocytoma (HP:0009592)2.32624777
35Abnormality of the astrocytes (HP:0100707)2.32624777
36Shallow orbits (HP:0000586)2.32230038
37Medulloblastoma (HP:0002885)2.31749350
38* Long eyelashes (HP:0000527)2.31432194
39* Abnormality of the intervertebral disk (HP:0005108)2.31346891
40Macroorchidism (HP:0000053)2.27173712
41Elfin facies (HP:0004428)2.27114451
42Hypoplasia of the thymus (HP:0000778)2.26864211
43Disproportionate tall stature (HP:0001519)2.26792795
44Partial duplication of thumb phalanx (HP:0009944)2.25912688
45Recurrent viral infections (HP:0004429)2.25670511
46Renovascular hypertension (HP:0100817)2.23574487
47Abnormal number of incisors (HP:0011064)2.21796141
48Increased density of long bones (HP:0006392)2.20842569
49Patellar dislocation (HP:0002999)2.19240540
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.18658678
51Limited elbow extension (HP:0001377)2.15684586
52Pointed chin (HP:0000307)2.15544928
53Sepsis (HP:0100806)2.15113170
54Osteomyelitis (HP:0002754)2.14351846
55Ankyloglossia (HP:0010296)2.11147823
56Obsessive-compulsive behavior (HP:0000722)2.10462232
57Partial duplication of the phalanx of hand (HP:0009999)2.09879786
58T lymphocytopenia (HP:0005403)2.09332846
59Overriding aorta (HP:0002623)2.08330720
60Duplication of thumb phalanx (HP:0009942)2.06258694
61Obstructive sleep apnea (HP:0002870)2.03162399
62Abnormality of chromosome segregation (HP:0002916)2.02341444
63Broad phalanges of the hand (HP:0009768)2.02321421
64Heterotopia (HP:0002282)2.01688107
65Abnormality of the distal phalanx of the thumb (HP:0009617)2.01421574
66Insomnia (HP:0100785)2.00932038
67High pitched voice (HP:0001620)2.00197962
68* Cutis marmorata (HP:0000965)1.99899199
69Colon cancer (HP:0003003)1.98980295
70Arnold-Chiari malformation (HP:0002308)1.97188263
71Urethral obstruction (HP:0000796)1.96988574
72Overlapping toe (HP:0001845)1.96566733
73Broad finger (HP:0001500)1.96368088
74Missing ribs (HP:0000921)1.95918192
75Recurrent bronchitis (HP:0002837)1.95885618
7611 pairs of ribs (HP:0000878)1.95448896
77Basal cell carcinoma (HP:0002671)1.94119377
78Sandal gap (HP:0001852)1.92874644
79Pseudobulbar signs (HP:0002200)1.91997627
80Skin tags (HP:0010609)1.91823895
81Abnormality of cochlea (HP:0000375)1.90942018
82Abnormality of the phalanges of the hallux (HP:0010057)1.89836029
83Meningitis (HP:0001287)1.87804653
84Broad palm (HP:0001169)1.87000697
85Flattened epiphyses (HP:0003071)1.86931178
86Neoplasm of striated muscle (HP:0009728)1.86762263
87Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86428479
88Trigonocephaly (HP:0000243)1.86182195
89Truncus arteriosus (HP:0001660)1.84415212
90Bowel diverticulosis (HP:0005222)1.83803591
91Ectopic kidney (HP:0000086)1.83549959
92Rib fusion (HP:0000902)1.83268809
93Hepatoblastoma (HP:0002884)1.82774892
94Abnormality of the calcaneus (HP:0008364)1.82358130
95Hyperthyroidism (HP:0000836)1.82306084
96Precocious puberty (HP:0000826)1.81692692
97Malignant gastrointestinal tract tumors (HP:0006749)1.81316774
98Gastrointestinal carcinoma (HP:0002672)1.81316774
99Abnormality of T cell number (HP:0011839)1.81312531
100Truncal obesity (HP:0001956)1.81110139
101Prominent nose (HP:0000448)1.79956403
102Cutaneous melanoma (HP:0012056)1.79778335
103Cutaneous syndactyly (HP:0012725)1.79396330
104Generalized hypotonia (HP:0001290)1.78683958
105Morphological abnormality of the inner ear (HP:0011390)1.78251928
106Skull defect (HP:0001362)1.77935053
107* Patellar aplasia (HP:0006443)1.76980863
108Glioma (HP:0009733)1.75164995
109Thin ribs (HP:0000883)1.74682730
110Abnormality of cells of the erythroid lineage (HP:0012130)1.74373229
111Attention deficit hyperactivity disorder (HP:0007018)1.74310371
112Aqueductal stenosis (HP:0002410)1.74080369
113Enlarged penis (HP:0000040)1.72343484
114Abnormality of oral frenula (HP:0000190)1.72218627
115Megalocornea (HP:0000485)1.72062185
116Optic nerve coloboma (HP:0000588)1.70902048
117Selective tooth agenesis (HP:0001592)1.70443340
118Chromsome breakage (HP:0040012)1.70351815
119Abnormality of the diencephalon (HP:0010662)1.69615964
120Supernumerary ribs (HP:0005815)1.68444120
121Low anterior hairline (HP:0000294)1.68057983
122* Aplasia/Hypoplasia of the patella (HP:0006498)1.66826211
123Sacral dimple (HP:0000960)1.66648659
124Bronchomalacia (HP:0002780)1.66175834
125Broad thumb (HP:0011304)1.66007499
126Subacute progressive viral hepatitis (HP:0006572)1.65708473
127Neoplasm of the oral cavity (HP:0100649)1.65290693
128Cafe-au-lait spot (HP:0000957)1.65072082
129Vertebral clefting (HP:0008428)1.64467889
130Atresia of the external auditory canal (HP:0000413)1.63763868
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.63684702
132Broad phalanx (HP:0006009)1.62155238
133Flat cornea (HP:0007720)1.61415893
134* Spina bifida occulta (HP:0003298)1.61257178
135Asymmetry of the thorax (HP:0001555)1.60966758
136Preauricular skin tag (HP:0000384)1.60690650
137Partial agenesis of the corpus callosum (HP:0001338)1.60688694
138Gastrointestinal inflammation (HP:0004386)1.60237536
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59513542
140Absent epiphyses (HP:0010577)1.59513542
141Cutaneous finger syndactyly (HP:0010554)1.59115375
142Colitis (HP:0002583)1.58945857
143Neoplasm of the heart (HP:0100544)1.58161407
144Cerebral aneurysm (HP:0004944)1.58078827
145Angiofibromas (HP:0010615)1.57879138
146Vesicoureteral reflux (HP:0000076)1.56941989
147Horseshoe kidney (HP:0000085)1.56758672
148Cheekbone underdevelopment (HP:0010669)1.55884295
149Broad face (HP:0000283)1.55720978
150Down-sloping shoulders (HP:0200021)1.54810640
151Abnormality of reticulocytes (HP:0004312)1.54179675
152Shawl scrotum (HP:0000049)1.54177529
153Bilateral microphthalmos (HP:0007633)1.53536876
154Self-mutilation (HP:0000742)1.53228066
155Coronal craniosynostosis (HP:0004440)1.53209991
156Hypoplasia of the brainstem (HP:0002365)1.52876788
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.52876788
158Dysmetric saccades (HP:0000641)1.52785418
159Broad long bones (HP:0005622)1.52570502
160Bowel incontinence (HP:0002607)1.52207146
161Abnormality of abdominal situs (HP:0011620)1.51712955
162Abdominal situs inversus (HP:0003363)1.51712955
163Choanal stenosis (HP:0000452)1.51422543
164Abnormality of the parietal bone (HP:0002696)1.49745318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K108.36336934
2EEF2K4.48939308
3CDK123.54846978
4SMG13.28961783
5CDC72.79148651
6TRIB32.74413952
7NEK22.69198261
8PKN22.44016475
9SIK22.31262742
10ICK1.86215395
11GRK61.80559274
12BRD41.74470354
13CDK41.69611733
14ERN11.69106873
15RPS6KB21.68952165
16TLK11.67688746
17MARK11.56469909
18PASK1.54177943
19NTRK11.51082486
20PRKD31.39301177
21LATS21.36646988
22STK101.33080855
23STK41.30198000
24SCYL21.29924502
25BUB11.22055924
26IRAK31.17006967
27DYRK21.13759799
28MTOR1.10150823
29PTK61.09744217
30ATR1.07943870
31DYRK1B1.06811801
32NTRK21.06016244
33MAP4K11.03132650
34CHEK11.00429087
35TTK1.00012552
36CLK10.97717925
37TESK20.96924010
38CDK90.96883058
39MAP3K90.96558015
40MAP3K80.96492196
41CDK60.96196692
42VRK20.95004860
43LRRK20.94083857
44PRPF4B0.92986219
45NME20.92503907
46WEE10.90993564
47FGFR20.90446794
48BRAF0.89135008
49CASK0.87842504
50ALK0.86321396
51HIPK20.83412851
52CHEK20.83247476
53FGFR40.82852235
54DYRK30.82686965
55CDK11A0.81254066
56CDK20.80548524
57RIPK10.80003432
58AURKB0.79461643
59UHMK10.78942346
60CAMK1G0.78445403
61PTK20.77947637
62MAP3K70.77424827
63PIM10.77291963
64CDK70.77120574
65PDGFRA0.77062547
66PLK10.75652544
67CDK150.75627926
68EPHA20.75354339
69MKNK10.72563713
70BRSK10.70829683
71SIK10.70024879
72CDK180.69430815
73NEK10.69093928
74MELK0.68998512
75MKNK20.68201997
76MARK20.68140806
77TGFBR10.67598370
78MINK10.67500817
79MAP2K70.66590170
80BTK0.65779285
81ATM0.65562084
82TYRO30.65560532
83NME10.64866622
84PAK40.64134624
85RPS6KC10.63923420
86RPS6KL10.63923420
87TAF10.63499758
88CDK140.63211195
89CDK80.63167259
90CAMK1D0.62880961
91MAP2K20.62664636
92ARAF0.59169750
93MAPK110.57992665
94CDK10.57411557
95CSNK1D0.55578077
96SYK0.55345534
97AKT10.54569068
98PIM20.53812430
99RPS6KA40.52701479
100KSR10.52549710
101CSF1R0.51341616
102PLK40.50634984
103PLK30.50175045
104MAPK40.50020459
105IRAK20.49964706
106FGFR30.48922297
107RPS6KA60.48259346
108MAPK100.47163125
109PAK20.46997337
110TAOK10.46984341
111STK30.46910605
112TTN0.46679822
113BMX0.46090795
114TSSK60.46083098
115SRPK10.45461853
116MAPK140.43970696
117CAMKK10.43522813
118DMPK0.42531253
119PRKDC0.42489826
120ILK0.37999215
121AURKA0.37748508
122RPS6KA20.36379447
123RPS6KA10.35876863
124RPS6KB10.35819247
125CDC42BPA0.35615394
126GSK3B0.35427373
127PRKD10.35387040
128AKT20.34969862
129PNCK0.33519423
130HCK0.33351963
131MAPK90.32801060
132CSNK1E0.32793674
133EPHB20.32561999
134PRKD20.30994463
135TESK10.29669926
136MARK30.29444618
137FES0.28812638

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.94264891
2Mismatch repair_Homo sapiens_hsa034302.48552396
3Non-homologous end-joining_Homo sapiens_hsa034502.45016598
4Primary immunodeficiency_Homo sapiens_hsa053402.44952027
5Cell cycle_Homo sapiens_hsa041102.39996164
6Spliceosome_Homo sapiens_hsa030402.39651921
7Base excision repair_Homo sapiens_hsa034102.38781313
8B cell receptor signaling pathway_Homo sapiens_hsa046622.18342351
9mRNA surveillance pathway_Homo sapiens_hsa030152.17668909
10Chronic myeloid leukemia_Homo sapiens_hsa052202.04193620
11RNA transport_Homo sapiens_hsa030131.98379790
12Systemic lupus erythematosus_Homo sapiens_hsa053221.82376417
13Non-small cell lung cancer_Homo sapiens_hsa052231.66339650
14MicroRNAs in cancer_Homo sapiens_hsa052061.65516358
15Viral carcinogenesis_Homo sapiens_hsa052031.55115667
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53559333
17Colorectal cancer_Homo sapiens_hsa052101.53201066
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52093964
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44307029
20mTOR signaling pathway_Homo sapiens_hsa041501.42379821
21Alcoholism_Homo sapiens_hsa050341.41980863
22Biosynthesis of amino acids_Homo sapiens_hsa012301.40347637
23Endometrial cancer_Homo sapiens_hsa052131.40042992
24Notch signaling pathway_Homo sapiens_hsa043301.37908428
25Lysine degradation_Homo sapiens_hsa003101.37447077
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35314240
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35052126
28HTLV-I infection_Homo sapiens_hsa051661.34526910
29Glioma_Homo sapiens_hsa052141.33549019
30Homologous recombination_Homo sapiens_hsa034401.30683027
31Small cell lung cancer_Homo sapiens_hsa052221.28061564
32Nucleotide excision repair_Homo sapiens_hsa034201.26076052
33Basal cell carcinoma_Homo sapiens_hsa052171.24938950
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20505630
35Sulfur relay system_Homo sapiens_hsa041221.20255438
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19929342
37Pancreatic cancer_Homo sapiens_hsa052121.19745381
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18731331
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18230611
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.13638578
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12981097
42Acute myeloid leukemia_Homo sapiens_hsa052211.12415252
43Oocyte meiosis_Homo sapiens_hsa041141.11660721
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11187149
45Melanogenesis_Homo sapiens_hsa049161.11029295
46One carbon pool by folate_Homo sapiens_hsa006701.10970168
47Epstein-Barr virus infection_Homo sapiens_hsa051691.08977029
48p53 signaling pathway_Homo sapiens_hsa041151.08020000
49Fanconi anemia pathway_Homo sapiens_hsa034601.06526069
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05853433
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02561195
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01537605
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01351589
54Hippo signaling pathway_Homo sapiens_hsa043900.99926222
55VEGF signaling pathway_Homo sapiens_hsa043700.98106643
56Prostate cancer_Homo sapiens_hsa052150.97338676
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.92555050
58Bladder cancer_Homo sapiens_hsa052190.91228607
59Proteoglycans in cancer_Homo sapiens_hsa052050.90988411
60FoxO signaling pathway_Homo sapiens_hsa040680.90803465
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.89837961
62Viral myocarditis_Homo sapiens_hsa054160.89121648
63Adherens junction_Homo sapiens_hsa045200.88353288
64Vitamin B6 metabolism_Homo sapiens_hsa007500.86931331
65Renal cell carcinoma_Homo sapiens_hsa052110.86521519
66Hepatitis B_Homo sapiens_hsa051610.86040544
67RNA degradation_Homo sapiens_hsa030180.85388926
68Thyroid cancer_Homo sapiens_hsa052160.82978798
69Tight junction_Homo sapiens_hsa045300.82741316
70Hedgehog signaling pathway_Homo sapiens_hsa043400.82548853
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81162236
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80879754
73Herpes simplex infection_Homo sapiens_hsa051680.80247603
74Pathways in cancer_Homo sapiens_hsa052000.80232991
75ErbB signaling pathway_Homo sapiens_hsa040120.80181210
76RNA polymerase_Homo sapiens_hsa030200.80165796
77Wnt signaling pathway_Homo sapiens_hsa043100.77793058
78Gap junction_Homo sapiens_hsa045400.77606581
79Pentose phosphate pathway_Homo sapiens_hsa000300.76729752
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76341696
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75490983
82Apoptosis_Homo sapiens_hsa042100.75039667
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.74747265
84Prion diseases_Homo sapiens_hsa050200.74617389
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73759790
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73474137
87Type II diabetes mellitus_Homo sapiens_hsa049300.71806864
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.71395329
89T cell receptor signaling pathway_Homo sapiens_hsa046600.68465015
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66800481
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65965772
92Basal transcription factors_Homo sapiens_hsa030220.65676333
93Estrogen signaling pathway_Homo sapiens_hsa049150.65290595
94AMPK signaling pathway_Homo sapiens_hsa041520.64713638
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64676604
96Platelet activation_Homo sapiens_hsa046110.64343089
97HIF-1 signaling pathway_Homo sapiens_hsa040660.63073997
98Osteoclast differentiation_Homo sapiens_hsa043800.61994642
99Insulin signaling pathway_Homo sapiens_hsa049100.60919421
100Long-term potentiation_Homo sapiens_hsa047200.60632438
101Shigellosis_Homo sapiens_hsa051310.60140342
102Insulin resistance_Homo sapiens_hsa049310.59250940
103Ribosome_Homo sapiens_hsa030100.58891049
104Focal adhesion_Homo sapiens_hsa045100.58716348
105Nicotine addiction_Homo sapiens_hsa050330.58160968
106Synaptic vesicle cycle_Homo sapiens_hsa047210.58048396
107Cholinergic synapse_Homo sapiens_hsa047250.57751749
108Antigen processing and presentation_Homo sapiens_hsa046120.57466692
109Cocaine addiction_Homo sapiens_hsa050300.55993508
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55691779
111TGF-beta signaling pathway_Homo sapiens_hsa043500.55677588
112Choline metabolism in cancer_Homo sapiens_hsa052310.53973757
113Melanoma_Homo sapiens_hsa052180.53962161
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53286462
115Rap1 signaling pathway_Homo sapiens_hsa040150.52711261
116Toxoplasmosis_Homo sapiens_hsa051450.52025878
117Olfactory transduction_Homo sapiens_hsa047400.52020113
118Axon guidance_Homo sapiens_hsa043600.51885307
119Prolactin signaling pathway_Homo sapiens_hsa049170.51703557
120Chemokine signaling pathway_Homo sapiens_hsa040620.51121445
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50958618
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.50426788
123Dopaminergic synapse_Homo sapiens_hsa047280.50376842
124MAPK signaling pathway_Homo sapiens_hsa040100.49638064
125Pyrimidine metabolism_Homo sapiens_hsa002400.49585270
126GnRH signaling pathway_Homo sapiens_hsa049120.49199734
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47155286
128Dilated cardiomyopathy_Homo sapiens_hsa054140.46902274
129Inositol phosphate metabolism_Homo sapiens_hsa005620.46756504
130Steroid biosynthesis_Homo sapiens_hsa001000.45953437
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45639268
132Fructose and mannose metabolism_Homo sapiens_hsa000510.45501880
133Carbon metabolism_Homo sapiens_hsa012000.44362229

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