SMARCB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)5.38235227
2COPI coating of Golgi vesicle (GO:0048205)4.94419418
3Golgi transport vesicle coating (GO:0048200)4.94419418
4histone arginine methylation (GO:0034969)4.68511524
5protein retention in ER lumen (GO:0006621)4.47998004
6peptidyl-arginine methylation (GO:0018216)4.45965286
7peptidyl-arginine N-methylation (GO:0035246)4.45965286
8spliceosomal tri-snRNP complex assembly (GO:0000244)4.41181396
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.20323408
10establishment of viral latency (GO:0019043)4.18797854
11proline biosynthetic process (GO:0006561)4.06977399
12regulation of mammary gland epithelial cell proliferation (GO:0033599)4.05600325
13mitotic chromosome condensation (GO:0007076)4.02381381
14DNA strand elongation involved in DNA replication (GO:0006271)3.96041331
15protein maturation by protein folding (GO:0022417)3.89584998
16telomere maintenance via semi-conservative replication (GO:0032201)3.87874252
17proteasome assembly (GO:0043248)3.82797826
18DNA strand elongation (GO:0022616)3.80064468
19mitotic nuclear envelope reassembly (GO:0007084)3.72601931
20nuclear envelope reassembly (GO:0031468)3.72601931
21microtubule depolymerization (GO:0007019)3.67702897
22DNA replication initiation (GO:0006270)3.61533989
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.60418687
24DNA deamination (GO:0045006)3.56996677
25ribosomal small subunit assembly (GO:0000028)3.55969727
26L-serine metabolic process (GO:0006563)3.53855119
27heterochromatin organization (GO:0070828)3.53504149
28telomere maintenance via recombination (GO:0000722)3.48286787
29pentose-phosphate shunt (GO:0006098)3.45646688
30spliceosomal snRNP assembly (GO:0000387)3.42917657
31protein localization to chromosome, centromeric region (GO:0071459)3.42843711
32* nucleosome disassembly (GO:0006337)3.40658615
33* protein-DNA complex disassembly (GO:0032986)3.40658615
34mitotic recombination (GO:0006312)3.39797458
35kinetochore assembly (GO:0051382)3.38907717
36maturation of SSU-rRNA (GO:0030490)3.37260867
37pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.36807587
38viral mRNA export from host cell nucleus (GO:0046784)3.36524662
39pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.34142582
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.34052170
41dosage compensation (GO:0007549)3.33980607
42mitotic sister chromatid segregation (GO:0000070)3.33088650
43DNA topological change (GO:0006265)3.29026467
44telomere maintenance via telomere lengthening (GO:0010833)3.28852207
45ribosomal large subunit biogenesis (GO:0042273)3.28823943
46positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.28590820
473-UTR-mediated mRNA stabilization (GO:0070935)3.27021774
48histone H2A acetylation (GO:0043968)3.25048404
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24423044
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24297029
51kinetochore organization (GO:0051383)3.20897477
52transcription-coupled nucleotide-excision repair (GO:0006283)3.19773509
53base-excision repair (GO:0006284)3.19291894
54negative regulation of RNA splicing (GO:0033119)3.18790031
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.17522845
56DNA unwinding involved in DNA replication (GO:0006268)3.16326320
57mitotic metaphase plate congression (GO:0007080)3.15110029
58regulation of translational fidelity (GO:0006450)3.12473449
59spliceosomal complex assembly (GO:0000245)3.11917796
607-methylguanosine mRNA capping (GO:0006370)3.11473985
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10512704
62NADPH regeneration (GO:0006740)3.08911659
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.08374089
64maturation of 5.8S rRNA (GO:0000460)3.08085694
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.07237081
66regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05530390
67RNA capping (GO:0036260)3.04642358
687-methylguanosine RNA capping (GO:0009452)3.04642358
69cullin deneddylation (GO:0010388)3.04052729
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01954282
71sister chromatid segregation (GO:0000819)3.01778490
72negative regulation of mRNA metabolic process (GO:1903312)3.01760518
73pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.00774519
74negative regulation of telomere maintenance (GO:0032205)2.99765786
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99351856
76mitochondrial fusion (GO:0008053)2.99091576
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98163766
78negative regulation of ligase activity (GO:0051352)2.98163766
79establishment of integrated proviral latency (GO:0075713)2.98034665
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96689029
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96689029
82DNA ligation (GO:0006266)2.96532833
83glucose catabolic process (GO:0006007)2.96315390
84DNA damage response, detection of DNA damage (GO:0042769)2.94490092
85positive regulation of receptor biosynthetic process (GO:0010870)2.94468571
86transcription elongation from RNA polymerase III promoter (GO:0006385)2.94432168
87termination of RNA polymerase III transcription (GO:0006386)2.94432168
88de novo posttranslational protein folding (GO:0051084)2.91684082
89intracellular estrogen receptor signaling pathway (GO:0030520)2.90842776
90protein deneddylation (GO:0000338)2.89230055
91viral transcription (GO:0019083)2.89124826
92negative regulation of mRNA processing (GO:0050686)2.87829349
93CENP-A containing nucleosome assembly (GO:0034080)2.87392075
94RNA splicing, via transesterification reactions (GO:0000375)2.85553027
95RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85401496
96mRNA splicing, via spliceosome (GO:0000398)2.85401496
97ribosomal small subunit biogenesis (GO:0042274)2.82841981
98deoxyribonucleotide biosynthetic process (GO:0009263)2.81534741
99DNA replication checkpoint (GO:0000076)2.81448900
100chaperone-mediated protein transport (GO:0072321)2.81332147
101pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.80317006
102regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.79551781
103nucleobase-containing small molecule interconversion (GO:0015949)2.79419067
104DNA replication-independent nucleosome organization (GO:0034724)2.78904684
105DNA replication-independent nucleosome assembly (GO:0006336)2.78904684
106deoxyribose phosphate biosynthetic process (GO:0046385)2.78440754
1072-deoxyribonucleotide biosynthetic process (GO:0009265)2.78440754
108de novo protein folding (GO:0006458)2.78107713
109protein complex localization (GO:0031503)2.77910519
110negative regulation of microtubule polymerization (GO:0031115)2.76958878
111negative regulation of cell size (GO:0045792)2.76846568
112regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76168775
113chromatin assembly (GO:0031497)2.75954724
114DNA replication-dependent nucleosome assembly (GO:0006335)2.75760744
115DNA replication-dependent nucleosome organization (GO:0034723)2.75760744
116GDP-mannose metabolic process (GO:0019673)2.74870641
117regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.74572404
118positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.74572404
119chromatin remodeling at centromere (GO:0031055)2.74559141
120pyrimidine nucleotide catabolic process (GO:0006244)2.73900301
121translational termination (GO:0006415)2.73045431
122mismatch repair (GO:0006298)2.71771393
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71342384
124negative regulation of sister chromatid segregation (GO:0033046)2.71342384
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.71342384
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71342384
127metaphase plate congression (GO:0051310)2.70271869
128mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.70139602
129regulation of double-strand break repair via homologous recombination (GO:0010569)2.69983305
130protein insertion into membrane (GO:0051205)2.69906202
131termination of RNA polymerase II transcription (GO:0006369)2.69585427
132formation of translation preinitiation complex (GO:0001731)2.68949519
133pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.68948747
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.68870838
135DNA duplex unwinding (GO:0032508)2.68852536
136regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.68628496
137spindle assembly checkpoint (GO:0071173)2.68028865
138DNA-templated transcription, termination (GO:0006353)2.67797724
139mitotic spindle assembly checkpoint (GO:0007094)2.67707161
140mitotic nuclear envelope disassembly (GO:0007077)2.67539559
141ribonucleoprotein complex biogenesis (GO:0022613)2.67201907
142negative regulation of chromosome segregation (GO:0051985)2.67069906
143negative regulation of DNA-templated transcription, elongation (GO:0032785)2.65883474
144negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.65883474
145CTP biosynthetic process (GO:0006241)2.65390881
146CTP metabolic process (GO:0046036)2.65390881
147signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.65251438
148signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.65251438
149signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.65251438
150transcription elongation from RNA polymerase I promoter (GO:0006362)2.65147603
151intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64059374
152signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64059374
153chromosome condensation (GO:0030261)2.63970726
154signal transduction involved in cell cycle checkpoint (GO:0072395)2.63758803
155negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.63472764
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.62659495
157rRNA transcription (GO:0009303)2.62651059
158mRNA stabilization (GO:0048255)2.62419115
159RNA stabilization (GO:0043489)2.62419115
160negative regulation of B cell apoptotic process (GO:0002903)2.62220424
161rRNA processing (GO:0006364)2.61676946
162metallo-sulfur cluster assembly (GO:0031163)2.61599816
163iron-sulfur cluster assembly (GO:0016226)2.61599816
164rRNA modification (GO:0000154)2.60946650
165termination of RNA polymerase I transcription (GO:0006363)2.60565642
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60062940
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.60008951
168regulation of DNA damage checkpoint (GO:2000001)2.59965050
169signal transduction involved in DNA damage checkpoint (GO:0072422)2.58443428
170signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58443428
171spindle checkpoint (GO:0031577)2.57354735
172UV protection (GO:0009650)2.57209435
173proline metabolic process (GO:0006560)2.57001721
174translational initiation (GO:0006413)2.56477823
175protein localization to kinetochore (GO:0034501)2.54500552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.61202792
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.66284488
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.60584796
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42508956
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28117879
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27869507
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.20519953
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09680496
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.08854747
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.03025929
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01434564
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.95471436
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74207121
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69286081
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66058616
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.64208090
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58586159
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57398755
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53921347
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.46857590
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.45550846
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44000150
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.43329451
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.41381685
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37477973
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35809193
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34028371
28XRN2_22483619_ChIP-Seq_HELA_Human2.24480241
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18380883
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.17543414
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08606245
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07496303
33VDR_21846776_ChIP-Seq_THP-1_Human2.02554159
34TTF2_22483619_ChIP-Seq_HELA_Human1.98357182
35VDR_23849224_ChIP-Seq_CD4+_Human1.98194375
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91850076
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91186033
38FOXP3_21729870_ChIP-Seq_TREG_Human1.89801370
39CIITA_25753668_ChIP-Seq_RAJI_Human1.88633773
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84603256
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.84422190
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81764780
43DCP1A_22483619_ChIP-Seq_HELA_Human1.79796883
44* LXR_22292898_ChIP-Seq_THP-1_Human1.73978138
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71236059
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70389479
47* GABP_19822575_ChIP-Seq_HepG2_Human1.68999780
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60287856
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.59334601
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56726860
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56606865
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55038185
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53816220
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53611073
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52462386
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.52300097
57ZNF263_19887448_ChIP-Seq_K562_Human1.52234074
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.51812797
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50142416
60ELK1_19687146_ChIP-ChIP_HELA_Human1.47968785
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46932545
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45557507
63* E2F1_21310950_ChIP-Seq_MCF-7_Human1.43536171
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43202222
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41933182
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41771903
67MYC_18940864_ChIP-ChIP_HL60_Human1.40994660
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40876943
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39730577
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38337426
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36759890
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35397527
73* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32970582
74RACK7_27058665_Chip-Seq_MCF-7_Human1.31209658
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30550143
76* EGR1_19374776_ChIP-ChIP_THP-1_Human1.30462263
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30368596
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28088940
79* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27102825
80P68_20966046_ChIP-Seq_HELA_Human1.26914515
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23405348
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20911901
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.19023005
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15229870
85KDM2B_26808549_Chip-Seq_DND41_Human1.14124952
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13237188
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11109224
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10032083
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09953850
90OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08935758
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.08697819
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.07838230
93FOXP1_21924763_ChIP-Seq_HESCs_Human1.07461224
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06433990
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05782098
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05555939
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04025709
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03628257
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03002597
100TCF7_22412390_ChIP-Seq_EML_Mouse1.02486655
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01766802
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01529945
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01511250
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00902176
105TP63_17297297_ChIP-ChIP_HaCaT_Human1.00391720
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00266894
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99641525
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99015970
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98504357
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98448082
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97794290
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96914294
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96558805
114* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96475214
115SMC4_20622854_ChIP-Seq_HELA_Human0.95560542
116IRF1_19129219_ChIP-ChIP_H3396_Human0.92139955
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91594370
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91383136
119KDM5A_27292631_Chip-Seq_BREAST_Human0.91362055
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.91026840
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90862030
122E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90695638
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.90080520
124ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89546766
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86647408
126YY1_22570637_ChIP-Seq_MALME-3M_Human0.84756982
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.84408135
128AR_21909140_ChIP-Seq_LNCAP_Human0.84360227
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83675583
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79666484
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79407118
132EZH2_22144423_ChIP-Seq_EOC_Human0.78386294
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77945470
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.77848654
135* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77520554
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72422582
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72305798
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.71214586
139MYC_22102868_ChIP-Seq_BL_Human0.69067932
140RNF2_27304074_Chip-Seq_NSC_Mouse0.68846207
141NANOG_21062744_ChIP-ChIP_HESCs_Human0.68272703
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.66994953
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.66766402
144KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.66766402
145KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.66766402
146FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66315598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.84281616
2MP0003111_abnormal_nucleus_morphology3.13896538
3MP0008058_abnormal_DNA_repair2.98042198
4MP0010094_abnormal_chromosome_stability2.89219515
5* MP0003693_abnormal_embryo_hatching2.82139950
6MP0003077_abnormal_cell_cycle2.60792138
7MP0000566_synostosis2.54723340
8MP0003136_yellow_coat_color2.40334106
9MP0002102_abnormal_ear_morphology2.36068906
10* MP0004957_abnormal_blastocyst_morpholog2.34801828
11MP0009278_abnormal_bone_marrow2.30784380
12MP0000049_abnormal_middle_ear2.18185127
13MP0008057_abnormal_DNA_replication2.17993190
14MP0008260_abnormal_autophagy2.15995313
15* MP0008932_abnormal_embryonic_tissue2.13774818
16MP0010030_abnormal_orbit_morphology2.04093475
17MP0004858_abnormal_nervous_system2.03829580
18MP0003705_abnormal_hypodermis_morpholog1.92584924
19MP0008007_abnormal_cellular_replicative1.89638891
20MP0003786_premature_aging1.85687260
21MP0003315_abnormal_perineum_morphology1.82437402
22MP0008789_abnormal_olfactory_epithelium1.82371515
23MP0004233_abnormal_muscle_weight1.79567202
24MP0009672_abnormal_birth_weight1.76559619
25MP0002653_abnormal_ependyma_morphology1.74427174
26MP0001849_ear_inflammation1.71698519
27MP0005076_abnormal_cell_differentiation1.71649367
28MP0003121_genomic_imprinting1.70765298
29MP0001188_hyperpigmentation1.70021495
30MP0005623_abnormal_meninges_morphology1.68804542
31MP0005058_abnormal_lysosome_morphology1.67432618
32MP0005501_abnormal_skin_physiology1.63924752
33MP0002249_abnormal_larynx_morphology1.61936437
34MP0005409_darkened_coat_color1.60662952
35MP0002822_catalepsy1.58876396
36MP0003938_abnormal_ear_development1.58846768
37MP0005451_abnormal_body_composition1.54556675
38MP0002938_white_spotting1.53636970
39MP0000015_abnormal_ear_pigmentation1.52684491
40MP0002751_abnormal_autonomic_nervous1.51182167
41MP0008877_abnormal_DNA_methylation1.49604592
42MP0005394_taste/olfaction_phenotype1.47301974
43MP0005499_abnormal_olfactory_system1.47301974
44MP0002877_abnormal_melanocyte_morpholog1.46464245
45MP0003123_paternal_imprinting1.38805653
46MP0001346_abnormal_lacrimal_gland1.36228231
47MP0005174_abnormal_tail_pigmentation1.31984548
48MP0003937_abnormal_limbs/digits/tail_de1.30468044
49MP0003984_embryonic_growth_retardation1.28246560
50MP0005257_abnormal_intraocular_pressure1.27037102
51MP0009250_abnormal_appendicular_skeleto1.25366152
52MP0004185_abnormal_adipocyte_glucose1.24439475
53MP0002160_abnormal_reproductive_system1.23329911
54MP0002697_abnormal_eye_size1.21756673
55MP0000358_abnormal_cell_content/1.20074245
56MP0000631_abnormal_neuroendocrine_gland1.19758881
57MP0003122_maternal_imprinting1.19440290
58MP0002396_abnormal_hematopoietic_system1.19352885
59MP0002092_abnormal_eye_morphology1.16732991
60MP0002088_abnormal_embryonic_growth/wei1.15966374
61MP0008995_early_reproductive_senescence1.15587065
62MP0002210_abnormal_sex_determination1.14420670
63MP0003890_abnormal_embryonic-extraembry1.14361228
64MP0003119_abnormal_digestive_system1.13245668
65MP0002089_abnormal_postnatal_growth/wei1.13097150
66MP0003385_abnormal_body_wall1.12749871
67MP0000678_abnormal_parathyroid_gland1.12002925
68MP0000003_abnormal_adipose_tissue1.11699968
69MP0004197_abnormal_fetal_growth/weight/1.10900647
70MP0006035_abnormal_mitochondrial_morpho1.10031655
71MP0001730_embryonic_growth_arrest1.09990940
72MP0000350_abnormal_cell_proliferation1.09934046
73MP0001293_anophthalmia1.09673431
74MP0003221_abnormal_cardiomyocyte_apopto1.09229230
75MP0003755_abnormal_palate_morphology1.08733314
76MP0005384_cellular_phenotype1.08679445
77MP0002085_abnormal_embryonic_tissue1.08325958
78MP0000026_abnormal_inner_ear1.07306578
79MP0009379_abnormal_foot_pigmentation1.07037645
80MP0006072_abnormal_retinal_apoptosis1.06895072
81MP0003787_abnormal_imprinting1.06408039
82MP0004133_heterotaxia1.04591354
83MP0002095_abnormal_skin_pigmentation1.04264739
84MP0005621_abnormal_cell_physiology1.04232499
85* MP0002019_abnormal_tumor_incidence1.03899671
86MP0003566_abnormal_cell_adhesion1.03361334
87MP0002277_abnormal_respiratory_mucosa1.02980769
88MP0002177_abnormal_outer_ear1.02933438
89MP0005171_absent_coat_pigmentation1.02843822
90MP0002116_abnormal_craniofacial_bone1.02213042
91MP0003329_amyloid_beta_deposits1.01993579
92MP0002163_abnormal_gland_morphology1.01819236
93MP0001986_abnormal_taste_sensitivity1.00813080
94MP0004134_abnormal_chest_morphology1.00108527
95MP0003861_abnormal_nervous_system0.99300239
96MP0003942_abnormal_urinary_system0.99275238
97MP0003115_abnormal_respiratory_system0.98725032
98MP0003935_abnormal_craniofacial_develop0.96403879
99MP0000490_abnormal_crypts_of0.95319501
100MP0001286_abnormal_eye_development0.93705889
101MP0001919_abnormal_reproductive_system0.93440268
102MP0010307_abnormal_tumor_latency0.92188196
103MP0000778_abnormal_nervous_system0.90556735
104MP0002233_abnormal_nose_morphology0.89952772
105MP0002132_abnormal_respiratory_system0.89928631
106MP0001529_abnormal_vocalization0.88855989
107MP0005075_abnormal_melanosome_morpholog0.87883699
108MP0000372_irregular_coat_pigmentation0.86558016
109MP0001485_abnormal_pinna_reflex0.85845490
110MP0005389_reproductive_system_phenotype0.85760619
111MP0002111_abnormal_tail_morphology0.85062403
112MP0003763_abnormal_thymus_physiology0.85047635
113MP0001348_abnormal_lacrimal_gland0.84336508
114MP0004859_abnormal_synaptic_plasticity0.83904940
115MP0000858_altered_metastatic_potential0.83183545
116MP0002282_abnormal_trachea_morphology0.82832583
117MP0002084_abnormal_developmental_patter0.82823588
118MP0001145_abnormal_male_reproductive0.81558297
119MP0001661_extended_life_span0.81487197
120MP0005253_abnormal_eye_physiology0.80677320
121MP0000681_abnormal_thyroid_gland0.80275503
122MP0000428_abnormal_craniofacial_morphol0.79597032
123MP0000703_abnormal_thymus_morphology0.79398728
124MP0002752_abnormal_somatic_nervous0.77721690
125MP0003718_maternal_effect0.76967484
126* MP0002086_abnormal_extraembryonic_tissu0.76611299
127MP0005248_abnormal_Harderian_gland0.76451748
128MP0000534_abnormal_ureter_morphology0.76050798
129MP0002114_abnormal_axial_skeleton0.75250901
130MP0000762_abnormal_tongue_morphology0.74864392
131MP0001270_distended_abdomen0.74618592
132MP0005380_embryogenesis_phenotype0.74182778
133MP0001672_abnormal_embryogenesis/_devel0.74182778
134* MP0000313_abnormal_cell_death0.74061036
135MP0001340_abnormal_eyelid_morphology0.73360670
136MP0001915_intracranial_hemorrhage0.73307198
137MP0000733_abnormal_muscle_development0.72831980
138MP0002932_abnormal_joint_morphology0.72828796
139MP0001963_abnormal_hearing_physiology0.72716129
140* MP0002080_prenatal_lethality0.72118120
141MP0000537_abnormal_urethra_morphology0.72045146
142MP0009333_abnormal_splenocyte_physiolog0.70825358
143MP0001697_abnormal_embryo_size0.70764644
144MP0004811_abnormal_neuron_physiology0.69338046
145MP0000751_myopathy0.69282175
146MP0004808_abnormal_hematopoietic_stem0.69256786
147MP0002098_abnormal_vibrissa_morphology0.68696879
148MP0009053_abnormal_anal_canal0.67653492
149MP0000477_abnormal_intestine_morphology0.66640517
150MP0000747_muscle_weakness0.66296381
151* MP0002081_perinatal_lethality0.65861728
152MP0002234_abnormal_pharynx_morphology0.65524786

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.92291913
2Hyperacusis (HP:0010780)3.73618988
3Chromsome breakage (HP:0040012)3.63476126
4Meckel diverticulum (HP:0002245)3.19185265
5Reticulocytopenia (HP:0001896)3.17411836
6Ragged-red muscle fibers (HP:0003200)3.17023180
7Cortical dysplasia (HP:0002539)3.09244251
8Abnormality of the ileum (HP:0001549)3.05544579
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.99793668
10Insomnia (HP:0100785)2.99015253
11Septo-optic dysplasia (HP:0100842)2.92793648
12Abnormality of the preputium (HP:0100587)2.89500646
13* Patellar aplasia (HP:0006443)2.79118048
14Long palpebral fissure (HP:0000637)2.76195831
15Birth length less than 3rd percentile (HP:0003561)2.75395150
16Abnormal gallbladder physiology (HP:0012438)2.69731761
17Cholecystitis (HP:0001082)2.69731761
18Progressive muscle weakness (HP:0003323)2.69226701
19Vertebral compression fractures (HP:0002953)2.67875215
20* Aplasia/Hypoplasia of the patella (HP:0006498)2.67313522
21Multiple enchondromatosis (HP:0005701)2.64669901
22High anterior hairline (HP:0009890)2.64648693
23Truncus arteriosus (HP:0001660)2.60552565
24Achilles tendon contracture (HP:0001771)2.58549103
25True hermaphroditism (HP:0010459)2.54523277
26Cerebral hypomyelination (HP:0006808)2.54280236
27Abnormality of the renal collecting system (HP:0004742)2.54195419
28Abnormal number of incisors (HP:0011064)2.49194238
29Nephroblastoma (Wilms tumor) (HP:0002667)2.47871335
30Duplicated collecting system (HP:0000081)2.47588017
31Abnormality of chromosome stability (HP:0003220)2.45206540
32Proximal placement of thumb (HP:0009623)2.42832611
33Abnormal lung lobation (HP:0002101)2.42497991
34Small intestinal stenosis (HP:0012848)2.42295830
35Duodenal stenosis (HP:0100867)2.42295830
36Triphalangeal thumb (HP:0001199)2.40242767
37Overriding aorta (HP:0002623)2.40198562
38Hand muscle atrophy (HP:0009130)2.36183001
39Pointed chin (HP:0000307)2.35433431
40Embryonal renal neoplasm (HP:0011794)2.32619680
41Upper limb amyotrophy (HP:0009129)2.32103418
42Distal upper limb amyotrophy (HP:0007149)2.32103418
43Trismus (HP:0000211)2.30408213
44Agammaglobulinemia (HP:0004432)2.27856028
45Aplastic anemia (HP:0001915)2.25168657
46Poikiloderma (HP:0001029)2.25162694
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22762624
48Entropion (HP:0000621)2.22386188
49Abnormality of DNA repair (HP:0003254)2.22244730
50Deep palmar crease (HP:0006191)2.20936848
51Abnormal sex determination (HP:0012244)2.19404881
52Sex reversal (HP:0012245)2.19404881
53Severe visual impairment (HP:0001141)2.18573966
54Deviation of the thumb (HP:0009603)2.18223895
55Type I transferrin isoform profile (HP:0003642)2.17341080
56Hyperthyroidism (HP:0000836)2.16454772
57Abnormality of the Achilles tendon (HP:0005109)2.16091902
58Absent septum pellucidum (HP:0001331)2.15666866
59Hypertensive crisis (HP:0100735)2.14983851
60Irregular epiphyses (HP:0010582)2.14176623
61Absent thumb (HP:0009777)2.14065521
62Microretrognathia (HP:0000308)2.14057296
63Flattened epiphyses (HP:0003071)2.13775351
64Breast hypoplasia (HP:0003187)2.13723515
65Abnormality of the septum pellucidum (HP:0007375)2.13132563
66Trigonocephaly (HP:0000243)2.12486161
67Abnormality of the labia minora (HP:0012880)2.11626531
68Patellar dislocation (HP:0002999)2.10065980
69Ectopic kidney (HP:0000086)2.09363720
70Increased nuchal translucency (HP:0010880)2.08425321
71Preaxial hand polydactyly (HP:0001177)2.07275800
72Abnormality of the carotid arteries (HP:0005344)2.06929367
73Duplication of thumb phalanx (HP:0009942)2.06319031
74Supernumerary spleens (HP:0009799)2.05574554
75Absent radius (HP:0003974)2.05451034
76Biconcave vertebral bodies (HP:0004586)2.05398045
77Abnormality of cells of the erythroid lineage (HP:0012130)2.03773700
78Elfin facies (HP:0004428)2.03729324
79Ulnar bowing (HP:0003031)2.02989250
80Optic nerve coloboma (HP:0000588)2.02974947
81Premature skin wrinkling (HP:0100678)2.02903924
82Abnormality of the duodenum (HP:0002246)2.02468648
83Cellulitis (HP:0100658)2.02142727
84Abnormal number of erythroid precursors (HP:0012131)2.00681635
85Bone marrow hypocellularity (HP:0005528)2.00565248
86Renal duplication (HP:0000075)2.00407356
8711 pairs of ribs (HP:0000878)1.99755952
88Premature graying of hair (HP:0002216)1.97515140
89Absent forearm bone (HP:0003953)1.97462186
90Aplasia involving forearm bones (HP:0009822)1.97462186
91Clubbing of toes (HP:0100760)1.96028257
92Abnormality of glycolysis (HP:0004366)1.95986762
93Horseshoe kidney (HP:0000085)1.93961463
94Centrally nucleated skeletal muscle fibers (HP:0003687)1.93520221
95Pendular nystagmus (HP:0012043)1.93370217
96Pancreatic cysts (HP:0001737)1.93322606
97Anencephaly (HP:0002323)1.93290023
98Myopathic facies (HP:0002058)1.92400098
99Spastic diplegia (HP:0001264)1.91901087
100Pancreatic fibrosis (HP:0100732)1.90139079
101Selective tooth agenesis (HP:0001592)1.89419993
102Abnormality of the calcaneus (HP:0008364)1.89183881
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89160850
104Squamous cell carcinoma (HP:0002860)1.89073566
105Distal lower limb amyotrophy (HP:0008944)1.88394271
106Abnormality of the incisor (HP:0000676)1.87731595
107Oral leukoplakia (HP:0002745)1.86874444
108Short thumb (HP:0009778)1.85683370
109Hypoplasia of the radius (HP:0002984)1.85302540
110Tracheoesophageal fistula (HP:0002575)1.83375531
111Rough bone trabeculation (HP:0100670)1.83177743
112Broad distal phalanx of finger (HP:0009836)1.82835928
113Pallor (HP:0000980)1.82504567
114Generalized hypotonia (HP:0001290)1.82065182
115Shoulder girdle muscle weakness (HP:0003547)1.81393374
116Sloping forehead (HP:0000340)1.81245984
117Growth hormone excess (HP:0000845)1.80500669
118Glossoptosis (HP:0000162)1.80484358
119Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78704609
120Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78704609
121Back pain (HP:0003418)1.78074771
122Optic nerve hypoplasia (HP:0000609)1.77003881
123Self-mutilation (HP:0000742)1.76616653
124Abnormality of the thoracic spine (HP:0100711)1.76474306
125Adducted thumb (HP:0001181)1.75276735
126Seborrheic dermatitis (HP:0001051)1.75166144
127Split foot (HP:0001839)1.74538115
128Peripheral hypomyelination (HP:0007182)1.74207103
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73486472
130Absent epiphyses (HP:0010577)1.73486472
131Thoracic kyphosis (HP:0002942)1.73099427
132Abnormality of reticulocytes (HP:0004312)1.72798397
133Abnormality of the umbilical cord (HP:0010881)1.72093365
134Colon cancer (HP:0003003)1.71740685
135Disproportionate tall stature (HP:0001519)1.71517753
136Hypoplastic pelvis (HP:0008839)1.70812581
137Myelodysplasia (HP:0002863)1.69698139
138Large eyes (HP:0001090)1.69343112
139Atelectasis (HP:0100750)1.67860085
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.67115843
141Aganglionic megacolon (HP:0002251)1.66759772
142Abnormal rod and cone electroretinograms (HP:0008323)1.66550264
143Renovascular hypertension (HP:0100817)1.65836277
144Abdominal situs inversus (HP:0003363)1.65418264
145Abnormality of abdominal situs (HP:0011620)1.65418264
146Abnormality of the phalanges of the hallux (HP:0010057)1.64453093
147Orthostatic hypotension (HP:0001278)1.64449988
148Facial cleft (HP:0002006)1.63928000
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63373779
150Hypoparathyroidism (HP:0000829)1.62844337
151Pseudobulbar signs (HP:0002200)1.62660125
152Type 2 muscle fiber atrophy (HP:0003554)1.62494279
153Abnormality of the motor neurons (HP:0002450)1.62397695
154Abnormal neuron morphology (HP:0012757)1.62397695
155Abnormal large intestine physiology (HP:0012700)1.62244988
156Stridor (HP:0010307)1.62006186
157Microvesicular hepatic steatosis (HP:0001414)1.61680022
158Bowel incontinence (HP:0002607)1.61642051
159Atresia of the external auditory canal (HP:0000413)1.60328563
160Nasolacrimal duct obstruction (HP:0000579)1.60066957
161Aplasia/Hypoplasia of the earlobes (HP:0009906)1.59873096
162Ependymoma (HP:0002888)1.58151653
163Abnormality of the tricuspid valve (HP:0001702)1.57865769
164Overlapping toe (HP:0001845)1.57705998
165Preauricular skin tag (HP:0000384)1.57700605
166Reticulocytosis (HP:0001923)1.56804575
167Diminished motivation (HP:0000745)1.56540348
168Carpal bone hypoplasia (HP:0001498)1.56396919
169Sclerocornea (HP:0000647)1.56342724
170Tetralogy of Fallot (HP:0001636)1.55786432
171Neoplasm of the pancreas (HP:0002894)1.55584810
172Abnormality of the lower motor neuron (HP:0002366)1.55096987
173Premature rupture of membranes (HP:0001788)1.55032914
174Partial duplication of thumb phalanx (HP:0009944)1.54687386
175Precocious puberty (HP:0000826)1.54632524
176Progressive external ophthalmoplegia (HP:0000590)1.53805406
177Abnormally folded helix (HP:0008544)1.53688834
178Cleft eyelid (HP:0000625)1.52537863
179Congenital stationary night blindness (HP:0007642)1.51158424
180Muscle fiber atrophy (HP:0100295)1.51145173
181Renal agenesis (HP:0000104)1.51088120
182Patent foramen ovale (HP:0001655)1.50900167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.18422136
2STK163.40552709
3MKNK23.30728077
4SMG13.24387769
5MKNK13.07936039
6TRIB33.03045503
7SRPK12.87841916
8EIF2AK12.82868445
9VRK22.64490568
10MAP3K102.58694554
11TNIK2.48854820
12ICK2.38035645
13CASK2.31072155
14CDC72.28879068
15WEE12.25966677
16ERN12.20392886
17PLK42.19747316
18TLK12.14286690
19EIF2AK32.05953409
20BCKDK1.90433333
21DYRK21.89748297
22VRK11.88711184
23CDK121.83892558
24TSSK61.83356381
25ARAF1.79239054
26SCYL21.72828518
27TESK21.71310725
28SIK31.70534574
29DYRK31.66267510
30CCNB11.64277010
31PLK11.60559186
32BRSK11.59677004
33KDR1.59260983
34CDK81.57766621
35EIF2AK21.57715364
36BLK1.53399969
37IRAK31.51069131
38PRPF4B1.47361984
39ACVR1B1.47327257
40YES11.46705542
41MAPK131.45614144
42NEK21.43866214
43CDK71.41819392
44PLK31.41704419
45ATR1.37673573
46TTK1.33844478
47BRSK21.32896224
48AURKA1.32669765
49CSNK1G31.29178063
50PASK1.28506869
51TAOK21.27378976
52NLK1.23597406
53NEK11.20676061
54ZAK1.19567848
55BRAF1.16015787
56BMPR1B1.14862425
57AURKB1.11093524
58SIK11.09120810
59CHEK21.04637795
60CSNK1A1L1.04194549
61CLK11.01693528
62BRD40.98557148
63RPS6KA40.96353479
64ADRBK20.95761062
65DAPK10.94872984
66TNK20.94310518
67PBK0.93338175
68LIMK10.93138131
69PIM20.92486375
70CDK140.89461907
71CDK40.89226358
72SIK20.88646050
73DYRK1B0.87240674
74PKN20.85312039
75FGFR40.84220388
76RPS6KB20.84079977
77LRRK20.83869679
78MAP3K80.83357844
79TGFBR10.82726917
80BCR0.82488001
81NTRK10.82023097
82UHMK10.81366503
83PAK10.80527851
84CDK190.80512327
85RPS6KA50.79777683
86CHEK10.79585126
87NME20.78995431
88IRAK20.77572009
89IRAK40.75190321
90DYRK1A0.74339777
91MARK10.72783963
92PRKD30.71953865
93CSNK1G20.70560017
94EPHB20.68530582
95ERBB30.67513674
96PRKCI0.66024085
97CDK90.65863068
98NME10.65762703
99MAP3K110.65376880
100PDGFRA0.64644866
101MAP2K20.63812841
102CSNK2A10.63486402
103MTOR0.60994354
104TESK10.60676127
105CDK10.58935120
106CDK20.58676692
107RAF10.56895613
108KSR20.56575788
109MAP4K10.55626266
110PAK40.55563747
111MAPK110.54941065
112ATM0.54877389
113RIPK10.53009152
114EEF2K0.52796614
115PLK20.49469356
116CSNK2A20.47551218
117CDK60.44088611
118MAP2K70.43283373
119ILK0.42316561
120TXK0.41468871
121CSNK1G10.41085922
122PRKD20.38822243
123LMTK20.38620642
124PTK60.38348286
125MUSK0.37208597
126CDK180.37157756
127AKT20.36758807
128STK100.36652046
129PTK20.35642033
130DAPK30.35191477
131TBK10.35103393
132MAPK90.34628261
133ALK0.32978045
134IRAK10.31268668
135CDK11A0.30634900
136RPS6KC10.30046339
137RPS6KL10.30046339
138EPHA20.28646986
139RPS6KA60.27683443
140WNK30.27406781
141MST40.27392440
142MAPKAPK20.27274602
143GRK10.26590932
144CDK150.26164366
145CDK30.24023926
146RPS6KA20.23992038
147AKT10.23713055

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.07706107
2Mismatch repair_Homo sapiens_hsa034303.59349047
3Spliceosome_Homo sapiens_hsa030403.48757058
4Proteasome_Homo sapiens_hsa030503.38131244
5Ribosome_Homo sapiens_hsa030103.21493529
6RNA polymerase_Homo sapiens_hsa030203.11145011
7Homologous recombination_Homo sapiens_hsa034402.96596794
8Base excision repair_Homo sapiens_hsa034102.94184074
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84905676
10Nucleotide excision repair_Homo sapiens_hsa034202.75083033
11Fanconi anemia pathway_Homo sapiens_hsa034602.71245508
12Biosynthesis of amino acids_Homo sapiens_hsa012302.67548567
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50828238
14Sulfur relay system_Homo sapiens_hsa041222.50259913
15RNA transport_Homo sapiens_hsa030132.30885211
16Cell cycle_Homo sapiens_hsa041102.29005992
17Pyrimidine metabolism_Homo sapiens_hsa002402.16175664
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14798897
19Basal transcription factors_Homo sapiens_hsa030222.07567777
20Non-homologous end-joining_Homo sapiens_hsa034502.02541098
21Pentose phosphate pathway_Homo sapiens_hsa000302.01476980
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99432271
23Carbon metabolism_Homo sapiens_hsa012001.92158365
24mRNA surveillance pathway_Homo sapiens_hsa030151.65548886
25RNA degradation_Homo sapiens_hsa030181.62471834
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61797512
27One carbon pool by folate_Homo sapiens_hsa006701.46063869
28Fructose and mannose metabolism_Homo sapiens_hsa000511.39774193
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.36966055
30Bladder cancer_Homo sapiens_hsa052191.35106767
31Purine metabolism_Homo sapiens_hsa002301.34109731
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33397237
33Basal cell carcinoma_Homo sapiens_hsa052171.19050967
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18517381
35p53 signaling pathway_Homo sapiens_hsa041151.16240773
36Vibrio cholerae infection_Homo sapiens_hsa051101.16213013
37Epstein-Barr virus infection_Homo sapiens_hsa051691.15950500
38Fatty acid elongation_Homo sapiens_hsa000621.15048361
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14494708
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13218991
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11412003
42Phototransduction_Homo sapiens_hsa047441.10987112
43Galactose metabolism_Homo sapiens_hsa000521.08646833
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03291569
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03280803
46Folate biosynthesis_Homo sapiens_hsa007901.02053410
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01363383
48Non-small cell lung cancer_Homo sapiens_hsa052230.97969359
49Protein export_Homo sapiens_hsa030600.94841240
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91590058
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90703454
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90492038
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88436332
54Systemic lupus erythematosus_Homo sapiens_hsa053220.87403852
55Hedgehog signaling pathway_Homo sapiens_hsa043400.86237156
56Huntingtons disease_Homo sapiens_hsa050160.85725849
57Other glycan degradation_Homo sapiens_hsa005110.85256405
58Pancreatic cancer_Homo sapiens_hsa052120.84119266
59Steroid biosynthesis_Homo sapiens_hsa001000.83328775
60Prion diseases_Homo sapiens_hsa050200.79664946
61Herpes simplex infection_Homo sapiens_hsa051680.79067708
62Alcoholism_Homo sapiens_hsa050340.78072289
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.77028725
64Notch signaling pathway_Homo sapiens_hsa043300.76280389
65Primary immunodeficiency_Homo sapiens_hsa053400.76144997
66Oocyte meiosis_Homo sapiens_hsa041140.75145926
67Parkinsons disease_Homo sapiens_hsa050120.72291786
68Hippo signaling pathway_Homo sapiens_hsa043900.71427141
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70437264
70B cell receptor signaling pathway_Homo sapiens_hsa046620.68676942
71Oxidative phosphorylation_Homo sapiens_hsa001900.68382055
72Wnt signaling pathway_Homo sapiens_hsa043100.65930355
73HTLV-I infection_Homo sapiens_hsa051660.65595249
74Colorectal cancer_Homo sapiens_hsa052100.63974250
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62926904
76N-Glycan biosynthesis_Homo sapiens_hsa005100.61787236
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61323606
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60297480
79Phenylalanine metabolism_Homo sapiens_hsa003600.59970071
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58842875
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.58725605
82Viral carcinogenesis_Homo sapiens_hsa052030.58514878
83Arachidonic acid metabolism_Homo sapiens_hsa005900.58040771
84Regulation of autophagy_Homo sapiens_hsa041400.57605534
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57441498
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57164091
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56059133
88Asthma_Homo sapiens_hsa053100.55810900
89Lysine degradation_Homo sapiens_hsa003100.55355353
90MicroRNAs in cancer_Homo sapiens_hsa052060.55222851
91Salmonella infection_Homo sapiens_hsa051320.53855319
92Axon guidance_Homo sapiens_hsa043600.53422615
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53286313
94Vitamin B6 metabolism_Homo sapiens_hsa007500.50998650
95AMPK signaling pathway_Homo sapiens_hsa041520.50266125
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50221255
97Autoimmune thyroid disease_Homo sapiens_hsa053200.49703915
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47765455
99Glioma_Homo sapiens_hsa052140.47130597
100Pyruvate metabolism_Homo sapiens_hsa006200.44989715
101VEGF signaling pathway_Homo sapiens_hsa043700.43914512
102Nicotine addiction_Homo sapiens_hsa050330.43155387
103Shigellosis_Homo sapiens_hsa051310.42789955
104Insulin signaling pathway_Homo sapiens_hsa049100.42583223
105Pathways in cancer_Homo sapiens_hsa052000.42124495
106Arginine and proline metabolism_Homo sapiens_hsa003300.41460828
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41077722
108Sphingolipid metabolism_Homo sapiens_hsa006000.40273438
109Fatty acid metabolism_Homo sapiens_hsa012120.39683626
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.39548273
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38188133
112TGF-beta signaling pathway_Homo sapiens_hsa043500.37895453
113Thyroid cancer_Homo sapiens_hsa052160.37801112
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.37768145
115ErbB signaling pathway_Homo sapiens_hsa040120.37423320
116Glutathione metabolism_Homo sapiens_hsa004800.36774315
117Measles_Homo sapiens_hsa051620.35604296
118Apoptosis_Homo sapiens_hsa042100.31942188
119Hematopoietic cell lineage_Homo sapiens_hsa046400.30802589
120Allograft rejection_Homo sapiens_hsa053300.30727894
121Melanoma_Homo sapiens_hsa052180.30175420
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29706851
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28500564
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.28408179
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28064343
126Alzheimers disease_Homo sapiens_hsa050100.27553666
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27205067
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26234028
129Endometrial cancer_Homo sapiens_hsa052130.25925832
130Gap junction_Homo sapiens_hsa045400.23565514
131Hepatitis B_Homo sapiens_hsa051610.23105685
132Prostate cancer_Homo sapiens_hsa052150.21568174
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21270459
134Antigen processing and presentation_Homo sapiens_hsa046120.21135895
135Serotonergic synapse_Homo sapiens_hsa047260.18446106
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17940381
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.17921800
138Melanogenesis_Homo sapiens_hsa049160.17657476
139Small cell lung cancer_Homo sapiens_hsa052220.16630686
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16533489
141Ether lipid metabolism_Homo sapiens_hsa005650.14506686
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.14210866
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13392736
144Acute myeloid leukemia_Homo sapiens_hsa052210.12801073
145Morphine addiction_Homo sapiens_hsa050320.12671424
146Chronic myeloid leukemia_Homo sapiens_hsa052200.12411292
147Influenza A_Homo sapiens_hsa051640.11988719
148Ras signaling pathway_Homo sapiens_hsa040140.11497059

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