SMARCD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)5.21339604
2nuclear pore complex assembly (GO:0051292)5.01011645
3pre-miRNA processing (GO:0031054)4.71432883
4mitotic chromosome condensation (GO:0007076)4.64605536
5dendritic spine morphogenesis (GO:0060997)4.63872850
6synaptic vesicle maturation (GO:0016188)4.57367206
7locomotory exploration behavior (GO:0035641)4.32756523
8nuclear pore organization (GO:0006999)4.21505137
9layer formation in cerebral cortex (GO:0021819)4.20216906
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06489982
11mRNA stabilization (GO:0048255)4.04220705
12RNA stabilization (GO:0043489)4.04220705
13regulation of RNA export from nucleus (GO:0046831)4.03770670
14cell migration in hindbrain (GO:0021535)4.03050270
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97697436
16peptidyl-arginine omega-N-methylation (GO:0035247)3.93799186
17auditory behavior (GO:0031223)3.89483533
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86934376
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86927008
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.86796433
21positive regulation of synapse maturation (GO:0090129)3.83899016
22* nucleosome disassembly (GO:0006337)3.83710842
23* protein-DNA complex disassembly (GO:0032986)3.83710842
24regulation of synapse structural plasticity (GO:0051823)3.71508114
253-UTR-mediated mRNA stabilization (GO:0070935)3.70245538
26DNA topological change (GO:0006265)3.69533274
27regulation of mammary gland epithelial cell proliferation (GO:0033599)3.66708813
28pore complex assembly (GO:0046931)3.65687388
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.60581720
30peptidyl-arginine methylation (GO:0018216)3.58302882
31peptidyl-arginine N-methylation (GO:0035246)3.58302882
32regulation of nucleobase-containing compound transport (GO:0032239)3.56742325
33protein localization to chromosome, centromeric region (GO:0071459)3.51929187
34convergent extension (GO:0060026)3.49990136
35regulation of glutamate receptor signaling pathway (GO:1900449)3.49341641
36vocalization behavior (GO:0071625)3.43104388
37synaptic vesicle exocytosis (GO:0016079)3.42795383
38histone arginine methylation (GO:0034969)3.42638041
39regulation of neuronal synaptic plasticity (GO:0048168)3.40813570
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.39142846
41glutamate secretion (GO:0014047)3.38688645
42DNA duplex unwinding (GO:0032508)3.36409452
43regulation of chromatin binding (GO:0035561)3.30684678
44protein localization to synapse (GO:0035418)3.28775675
45regulation of NFAT protein import into nucleus (GO:0051532)3.25097010
46protein complex localization (GO:0031503)3.24037103
47axonal fasciculation (GO:0007413)3.22883056
48sister chromatid segregation (GO:0000819)3.22600508
49dendritic spine organization (GO:0097061)3.20171081
50protein localization to kinetochore (GO:0034501)3.20005513
51mitotic sister chromatid cohesion (GO:0007064)3.19274299
52mitotic sister chromatid segregation (GO:0000070)3.18928995
53negative regulation of microtubule polymerization (GO:0031115)3.18790580
54DNA strand elongation involved in DNA replication (GO:0006271)3.18731590
55DNA replication initiation (GO:0006270)3.18430015
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16791095
57exploration behavior (GO:0035640)3.16252407
58neuromuscular process controlling balance (GO:0050885)3.13641588
59DNA geometric change (GO:0032392)3.13377832
60DNA strand elongation (GO:0022616)3.12543175
61chromatin assembly (GO:0031497)3.10444138
62central nervous system projection neuron axonogenesis (GO:0021952)3.08847746
63Golgi transport vesicle coating (GO:0048200)3.08802944
64COPI coating of Golgi vesicle (GO:0048205)3.08802944
65negative regulation of mRNA metabolic process (GO:1903312)3.08234174
66proline biosynthetic process (GO:0006561)3.07277754
67regulation of synaptic vesicle exocytosis (GO:2000300)3.05227349
68regulation of histone H3-K27 methylation (GO:0061085)3.02201733
69negative regulation of organelle assembly (GO:1902116)3.01860246
70formation of translation preinitiation complex (GO:0001731)3.01852134
71adherens junction assembly (GO:0034333)3.01191212
72establishment of nucleus localization (GO:0040023)3.00225364
73protein export from nucleus (GO:0006611)2.99236440
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96837409
75regulation of histone H3-K9 methylation (GO:0051570)2.96334677
76apoptotic process involved in morphogenesis (GO:0060561)2.95644384
77positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.95336329
78response to auditory stimulus (GO:0010996)2.94532841
79chromosome condensation (GO:0030261)2.93655745
80cellular response to epidermal growth factor stimulus (GO:0071364)2.92127475
81regulation of gene silencing by RNA (GO:0060966)2.91978327
82regulation of posttranscriptional gene silencing (GO:0060147)2.91978327
83regulation of gene silencing by miRNA (GO:0060964)2.91978327
84regulation of mRNA stability (GO:0043488)2.91670474
85dosage compensation (GO:0007549)2.91278167
86positive regulation of dendritic spine morphogenesis (GO:0061003)2.91137291
87mechanosensory behavior (GO:0007638)2.87353332
88establishment of integrated proviral latency (GO:0075713)2.86397650
89focal adhesion assembly (GO:0048041)2.86145652
90cell-substrate adherens junction assembly (GO:0007045)2.86145652
91protein retention in ER lumen (GO:0006621)2.85383060
92DNA conformation change (GO:0071103)2.84465784
93regulation of dendritic spine morphogenesis (GO:0061001)2.84087060
94ribosomal small subunit biogenesis (GO:0042274)2.84003808
95paraxial mesoderm development (GO:0048339)2.82861958
96cerebellar Purkinje cell differentiation (GO:0021702)2.81928843
97cellular protein complex localization (GO:0034629)2.81882560
98regulation of sister chromatid cohesion (GO:0007063)2.81813331
99maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.80285253
100neurotransmitter secretion (GO:0007269)2.78354252
101neuron recognition (GO:0008038)2.78338136
102mitotic nuclear envelope disassembly (GO:0007077)2.76356539
103neuron cell-cell adhesion (GO:0007158)2.74426688
104regulation of RNA stability (GO:0043487)2.74031250
105negative regulation of oligodendrocyte differentiation (GO:0048715)2.72450946
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72018035
107G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.71951934
108spliceosomal tri-snRNP complex assembly (GO:0000244)2.71112845
109histone H3-K36 demethylation (GO:0070544)2.70990179
110membrane disassembly (GO:0030397)2.70865385
111nuclear envelope disassembly (GO:0051081)2.70865385
112peptidyl-lysine dimethylation (GO:0018027)2.69145653
113positive regulation of chromosome segregation (GO:0051984)2.67450861
114stress granule assembly (GO:0034063)2.66089426
115glucocorticoid receptor signaling pathway (GO:0042921)2.65950838
116Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.65928942
117regulation of synapse maturation (GO:0090128)2.65558035
118response to epidermal growth factor (GO:0070849)2.64349630
119activation of Rac GTPase activity (GO:0032863)2.62713020
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.62029358
121prepulse inhibition (GO:0060134)2.61769321
122regulation of stem cell maintenance (GO:2000036)2.61431225
123L-serine metabolic process (GO:0006563)2.60631385
124dendrite morphogenesis (GO:0048813)2.60093346
125negative regulation of mRNA processing (GO:0050686)2.60071238
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.59192409
127establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59082595
128neuronal ion channel clustering (GO:0045161)2.58336597
129sodium ion export (GO:0071436)2.57238051
130DNA unwinding involved in DNA replication (GO:0006268)2.57214274
131mRNA transport (GO:0051028)2.56779799
132intracellular estrogen receptor signaling pathway (GO:0030520)2.56777329
133regulation of synaptic vesicle transport (GO:1902803)2.55670556
134regulation of translational termination (GO:0006449)2.54208999
135cell communication by electrical coupling (GO:0010644)2.54055993
136regulation of establishment of planar polarity (GO:0090175)2.53964869
137regulation of synaptic plasticity (GO:0048167)2.53527298
138regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.52979219
139histone H4-K5 acetylation (GO:0043981)2.52867642
140histone H4-K8 acetylation (GO:0043982)2.52867642
141negative regulation of cell size (GO:0045792)2.52680184
142synaptic transmission, glutamatergic (GO:0035249)2.51799683
143positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.51700173
144regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.51700173
145synaptic vesicle endocytosis (GO:0048488)2.51308521
146regulation of histone methylation (GO:0031060)2.51215247
147regulation of glucose import in response to insulin stimulus (GO:2001273)2.51211235
148neural tube development (GO:0021915)2.50462012
149trophectodermal cell differentiation (GO:0001829)2.49808042
150embryonic process involved in female pregnancy (GO:0060136)2.49418154
151cerebellar Purkinje cell layer development (GO:0021680)2.49412198
152semaphorin-plexin signaling pathway (GO:0071526)2.48419442
153negative regulation of RNA splicing (GO:0033119)2.46347061
154ATP-dependent chromatin remodeling (GO:0043044)2.45792013
155positive regulation of RNA splicing (GO:0033120)2.45790112
156negative regulation of catenin import into nucleus (GO:0035414)2.45771956
157regulation of early endosome to late endosome transport (GO:2000641)2.44903092
158nuclear envelope organization (GO:0006998)2.44497698
159positive regulation of dendritic spine development (GO:0060999)2.43179730
160negative regulation of erythrocyte differentiation (GO:0045647)2.42916178
161neuromuscular process (GO:0050905)2.42713299
162regulation of translational fidelity (GO:0006450)2.42163148
163histone H4-K12 acetylation (GO:0043983)2.41801257
164long-term memory (GO:0007616)2.40569592
165positive regulation of membrane potential (GO:0045838)2.40541523
166positive regulation of dendrite morphogenesis (GO:0050775)2.38610353
167cerebellum development (GO:0021549)2.37691893
168neuron-neuron synaptic transmission (GO:0007270)2.36761580
169pyrimidine nucleobase catabolic process (GO:0006208)2.34454630
170negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34110828
171planar cell polarity pathway involved in neural tube closure (GO:0090179)2.33597746
172positive regulation of dendrite development (GO:1900006)2.32208646
173negative regulation of histone methylation (GO:0031061)2.32061111
174dopamine receptor signaling pathway (GO:0007212)2.31588608
175behavioral defense response (GO:0002209)2.31419252
176behavioral fear response (GO:0001662)2.31419252
177membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28815071
178activation of protein kinase A activity (GO:0034199)2.28366463
179head development (GO:0060322)2.27905563
180substrate-independent telencephalic tangential migration (GO:0021826)2.27264585
181substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.27264585
182positive regulation of synaptic transmission, GABAergic (GO:0032230)2.27003851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.00948131
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.33843982
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.18681262
4E2F7_22180533_ChIP-Seq_HELA_Human3.05937509
5* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.99218399
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.80815454
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76937872
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.64842849
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56255854
10* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.53785506
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51813046
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.50137824
13* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.42571079
14VDR_21846776_ChIP-Seq_THP-1_Human2.38204870
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34523827
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20670748
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12134480
18MYC_22102868_ChIP-Seq_BL_Human2.11203079
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.06884342
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03353461
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01335618
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99661721
23* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98534506
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97430428
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.94623647
26* XRN2_22483619_ChIP-Seq_HELA_Human1.87332293
27KDM2B_26808549_Chip-Seq_K562_Human1.86997367
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.83328574
29DROSHA_22980978_ChIP-Seq_HELA_Human1.82109134
30KDM2B_26808549_Chip-Seq_DND41_Human1.81703098
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81542394
32* REST_21632747_ChIP-Seq_MESCs_Mouse1.81295358
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.77353337
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77146853
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71964980
36* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71288304
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.68469382
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68426171
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.66952272
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66503018
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.65223470
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.65182001
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64538514
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64326850
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64326850
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63878945
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63811466
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62382137
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.62087364
50RACK7_27058665_Chip-Seq_MCF-7_Human1.61314857
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59298109
52* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59265356
53* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.56815654
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56389776
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.56036315
56ZNF263_19887448_ChIP-Seq_K562_Human1.51879294
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51313258
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.50627696
59* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50550514
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.48328187
61* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46834338
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46749913
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45988102
64NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45723181
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44760813
66CLOCK_20551151_ChIP-Seq_293T_Human1.43344772
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.43213187
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42616952
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41429160
70* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41169905
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.40535122
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39349047
73* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38477518
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37621140
75* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37545018
76CIITA_25753668_ChIP-Seq_RAJI_Human1.37455310
77EZH2_27294783_Chip-Seq_ESCs_Mouse1.36885943
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36491414
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35969824
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35814223
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35376246
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35029479
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35014002
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34715517
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.34150921
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.31295819
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30871647
88LXR_22292898_ChIP-Seq_THP-1_Human1.30744051
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30414618
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.29457770
91POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28260254
92AR_21909140_ChIP-Seq_LNCAP_Human1.28163463
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24050510
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22319803
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21218347
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21172381
97KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20898682
98KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20898682
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20898682
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19608819
101NCOR1_26117541_ChIP-Seq_K562_Human1.18427476
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.17494733
103* TET1_21451524_ChIP-Seq_MESCs_Mouse1.15945115
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15273808
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15185557
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14714317
107* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14467968
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14237590
109CREB1_26743006_Chip-Seq_LNCaP_Human1.14087106
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.13602927
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13101289
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12628344
113* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12584779
114* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11374546
115* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11177844
116TTF2_22483619_ChIP-Seq_HELA_Human1.11158829
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.10063336
118TCF7_22412390_ChIP-Seq_EML_Mouse1.09646550
119RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09613379
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09473541
121* MAF_26560356_Chip-Seq_TH1_Human1.09324027
122MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09183124
123UTX_26944678_Chip-Seq_JUKART_Human1.08982758
124SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07740426
125* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06904340
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.06780768
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06593465
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06590433
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05735891
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05502835
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05427498
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05372005
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04760005
134* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04680839
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04314201
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03401505
137SA1_27219007_Chip-Seq_ERYTHROID_Human1.03209997
138CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03202309
139KDM5A_27292631_Chip-Seq_BREAST_Human1.02764791
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02628609
141MAF_26560356_Chip-Seq_TH2_Human1.02316890
142CHD1_26751641_Chip-Seq_LNCaP_Human1.02271529
143OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02018436
144STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01837046
145PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00819977
146SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00238083
147IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00173581
148P68_20966046_ChIP-Seq_HELA_Human1.00156932
149CTCF_27219007_Chip-Seq_Bcells_Human0.99081232
150TP53_22127205_ChIP-Seq_IMR90_Human0.98059350
151ATF3_27146783_Chip-Seq_COLON_Human0.97744771
152* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97394916
153TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97054832
154RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95851032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.12547210
2MP0003705_abnormal_hypodermis_morpholog3.43101478
3MP0002653_abnormal_ependyma_morphology3.04990506
4MP0003635_abnormal_synaptic_transmissio2.82154216
5MP0003693_abnormal_embryo_hatching2.76534670
6MP0003880_abnormal_central_pattern2.57111682
7MP0002822_catalepsy2.50954555
8MP0002063_abnormal_learning/memory/cond2.41775215
9MP0009672_abnormal_birth_weight2.38584795
10MP0004270_analgesia2.38391104
11MP0003283_abnormal_digestive_organ2.36613294
12MP0000778_abnormal_nervous_system2.33767495
13MP0008057_abnormal_DNA_replication2.28403431
14MP0000537_abnormal_urethra_morphology2.15644255
15MP0005423_abnormal_somatic_nervous2.13228185
16MP0003122_maternal_imprinting2.08896304
17MP0005394_taste/olfaction_phenotype2.07983117
18MP0005499_abnormal_olfactory_system2.07983117
19MP0010030_abnormal_orbit_morphology2.03134083
20MP0004185_abnormal_adipocyte_glucose1.95320692
21MP0009745_abnormal_behavioral_response1.94707002
22MP0002064_seizures1.89897236
23MP0000566_synostosis1.85153729
24MP0009278_abnormal_bone_marrow1.82533627
25MP0003119_abnormal_digestive_system1.80358395
26MP0002572_abnormal_emotion/affect_behav1.76326484
27MP0001529_abnormal_vocalization1.76194901
28MP0002396_abnormal_hematopoietic_system1.75628662
29MP0004811_abnormal_neuron_physiology1.74222248
30MP0005409_darkened_coat_color1.74195091
31MP0003123_paternal_imprinting1.72572106
32MP0002697_abnormal_eye_size1.68158147
33MP0003121_genomic_imprinting1.68088203
34MP0008789_abnormal_olfactory_epithelium1.64690626
35MP0003890_abnormal_embryonic-extraembry1.64275346
36MP0008961_abnormal_basal_metabolism1.63689213
37MP0004858_abnormal_nervous_system1.63499002
38MP0010352_gastrointestinal_tract_polyps1.63473336
39MP0001486_abnormal_startle_reflex1.63393292
40MP0001348_abnormal_lacrimal_gland1.63390954
41MP0003861_abnormal_nervous_system1.62969926
42MP0003566_abnormal_cell_adhesion1.62663509
43MP0009046_muscle_twitch1.61609471
44MP0002184_abnormal_innervation1.60936858
45MP0000955_abnormal_spinal_cord1.60545683
46MP0002080_prenatal_lethality1.58515025
47MP0005451_abnormal_body_composition1.55777534
48MP0002877_abnormal_melanocyte_morpholog1.54622603
49MP0004133_heterotaxia1.50005131
50MP0002152_abnormal_brain_morphology1.45404113
51MP0004808_abnormal_hematopoietic_stem1.42077554
52MP0002086_abnormal_extraembryonic_tissu1.38371337
53MP0003787_abnormal_imprinting1.38332103
54MP0002272_abnormal_nervous_system1.38308163
55MP0002557_abnormal_social/conspecific_i1.37610821
56MP0005076_abnormal_cell_differentiation1.37473064
57MP0002084_abnormal_developmental_patter1.37159864
58MP0002092_abnormal_eye_morphology1.36533706
59MP0004233_abnormal_muscle_weight1.36027201
60MP0001346_abnormal_lacrimal_gland1.34150195
61MP0003938_abnormal_ear_development1.33824552
62MP0001968_abnormal_touch/_nociception1.33800997
63MP0002249_abnormal_larynx_morphology1.33596627
64MP0000678_abnormal_parathyroid_gland1.33162515
65MP0002882_abnormal_neuron_morphology1.30611657
66MP0005257_abnormal_intraocular_pressure1.30571902
67MP0004264_abnormal_extraembryonic_tissu1.28593372
68MP0004885_abnormal_endolymph1.27822731
69MP0002734_abnormal_mechanical_nocicepti1.27752692
70MP0005623_abnormal_meninges_morphology1.23839477
71MP0002085_abnormal_embryonic_tissue1.20738874
72MP0000490_abnormal_crypts_of1.20460215
73MP0008260_abnormal_autophagy1.19899353
74MP0010234_abnormal_vibrissa_follicle1.19731762
75MP0008569_lethality_at_weaning1.19500832
76MP0005386_behavior/neurological_phenoty1.19344383
77MP0004924_abnormal_behavior1.19344383
78MP0000049_abnormal_middle_ear1.17515049
79MP0009703_decreased_birth_body1.17301289
80MP0002733_abnormal_thermal_nociception1.15777452
81MP0005501_abnormal_skin_physiology1.14566738
82MP0001730_embryonic_growth_arrest1.14366323
83MP0003111_abnormal_nucleus_morphology1.13966134
84MP0000313_abnormal_cell_death1.13484208
85MP0002254_reproductive_system_inflammat1.13363669
86MP0003115_abnormal_respiratory_system1.12981320
87MP0000631_abnormal_neuroendocrine_gland1.12009850
88MP0001915_intracranial_hemorrhage1.11534174
89MP0004197_abnormal_fetal_growth/weight/1.10569675
90MP0010307_abnormal_tumor_latency1.10056717
91MP0008007_abnormal_cellular_replicative1.09719541
92MP0009053_abnormal_anal_canal1.06841549
93MP0006292_abnormal_olfactory_placode1.05059584
94MP0003453_abnormal_keratinocyte_physiol1.05042925
95MP0002111_abnormal_tail_morphology1.04577135
96MP0002009_preneoplasia1.03791691
97MP0002796_impaired_skin_barrier1.03425059
98MP0008877_abnormal_DNA_methylation1.02920899
99MP0002909_abnormal_adrenal_gland1.02874509
100MP0000569_abnormal_digit_pigmentation1.02298359
101MP0002066_abnormal_motor_capabilities/c1.01649767
102MP0000579_abnormal_nail_morphology1.01610675
103MP0001286_abnormal_eye_development1.01312762
104MP0000432_abnormal_head_morphology1.00133181
105MP0002234_abnormal_pharynx_morphology1.00019670
106MP0001849_ear_inflammation0.99769189
107MP0005621_abnormal_cell_physiology0.98635247
108MP0001970_abnormal_pain_threshold0.97870566
109MP0000534_abnormal_ureter_morphology0.97550503
110MP0005666_abnormal_adipose_tissue0.97433786
111MP0003567_abnormal_fetal_cardiomyocyte0.97148899
112MP0002067_abnormal_sensory_capabilities0.97094995
113MP0002751_abnormal_autonomic_nervous0.97039812
114MP0005646_abnormal_pituitary_gland0.94497826
115MP0003935_abnormal_craniofacial_develop0.94395313
116MP0000350_abnormal_cell_proliferation0.94330370
117MP0002081_perinatal_lethality0.93149122
118MP0004272_abnormal_basement_membrane0.92967749
119MP0001697_abnormal_embryo_size0.92537481
120MP0004957_abnormal_blastocyst_morpholog0.91029764
121MP0001440_abnormal_grooming_behavior0.90393580
122MP0003315_abnormal_perineum_morphology0.89951682
123MP0002089_abnormal_postnatal_growth/wei0.87919520
124MP0010630_abnormal_cardiac_muscle0.87865995
125MP0005380_embryogenesis_phenotype0.87565244
126MP0001672_abnormal_embryogenesis/_devel0.87565244
127MP0002116_abnormal_craniofacial_bone0.87375492
128MP0000428_abnormal_craniofacial_morphol0.87131664
129MP0003385_abnormal_body_wall0.87018130
130MP0010094_abnormal_chromosome_stability0.87007397
131MP0000003_abnormal_adipose_tissue0.85970817
132MP0001661_extended_life_span0.85886283
133MP0000703_abnormal_thymus_morphology0.85811425
134MP0003091_abnormal_cell_migration0.85671440
135MP0003077_abnormal_cell_cycle0.85628963
136MP0005187_abnormal_penis_morphology0.85342318
137MP0000733_abnormal_muscle_development0.84826619
138MP0003137_abnormal_impulse_conducting0.84368958
139MP0002114_abnormal_axial_skeleton0.84165536
140MP0009780_abnormal_chondrocyte_physiolo0.84003025
141MP0001340_abnormal_eyelid_morphology0.83259419
142MP0005384_cellular_phenotype0.80933484
143MP0002925_abnormal_cardiovascular_devel0.80843447
144MP0002752_abnormal_somatic_nervous0.80599589
145MP0000477_abnormal_intestine_morphology0.79345219
146MP0000762_abnormal_tongue_morphology0.79295358
147MP0008932_abnormal_embryonic_tissue0.78092146
148MP0001293_anophthalmia0.77677600
149MP0003755_abnormal_palate_morphology0.77157175
150MP0003942_abnormal_urinary_system0.76955258
151MP0002233_abnormal_nose_morphology0.75385306
152MP0008770_decreased_survivor_rate0.75067716
153MP0003984_embryonic_growth_retardation0.74994095
154MP0010769_abnormal_survival0.74193966
155MP0002088_abnormal_embryonic_growth/wei0.73925176
156MP0003937_abnormal_limbs/digits/tail_de0.73719585

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.17568364
2Annular pancreas (HP:0001734)3.60250713
3Astrocytoma (HP:0009592)3.28972743
4Abnormality of the astrocytes (HP:0100707)3.28972743
5Pointed chin (HP:0000307)3.15166828
6Ependymoma (HP:0002888)3.13427604
7Focal motor seizures (HP:0011153)3.06595510
8Hyperacusis (HP:0010780)3.06152210
9Renal duplication (HP:0000075)3.02655389
10Focal seizures (HP:0007359)2.99627471
11Abnormality of the lower motor neuron (HP:0002366)2.93938890
12Insomnia (HP:0100785)2.79296139
13Abnormality of the labia minora (HP:0012880)2.72057038
14Overriding aorta (HP:0002623)2.68467547
15Disproportionate tall stature (HP:0001519)2.56870763
16Elfin facies (HP:0004428)2.55424134
17Glioma (HP:0009733)2.50021115
18Abnormality of the aortic arch (HP:0012303)2.46564092
19Shallow orbits (HP:0000586)2.44606527
20Turricephaly (HP:0000262)2.41798542
21Asymmetry of the thorax (HP:0001555)2.41004920
22Arnold-Chiari malformation (HP:0002308)2.40159991
23Abnormality of the distal phalanx of the thumb (HP:0009617)2.38423363
24Selective tooth agenesis (HP:0001592)2.38121285
25Cortical dysplasia (HP:0002539)2.36236076
26Ankle clonus (HP:0011448)2.34035269
27Split foot (HP:0001839)2.34001051
28Visual hallucinations (HP:0002367)2.33562847
29Neoplasm of the heart (HP:0100544)2.32868345
30Ulnar bowing (HP:0003031)2.31206098
31Trigonocephaly (HP:0000243)2.29903572
32Flat acetabular roof (HP:0003180)2.28402762
33Pseudobulbar signs (HP:0002200)2.26726474
34Bilateral microphthalmos (HP:0007633)2.24966139
35Increased nuchal translucency (HP:0010880)2.24565718
36Broad thumb (HP:0011304)2.24119096
37Truncus arteriosus (HP:0001660)2.23014127
38Abnormal number of incisors (HP:0011064)2.20182426
39Renovascular hypertension (HP:0100817)2.19919737
40Short 4th metacarpal (HP:0010044)2.19436239
41Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19436239
42Impaired vibration sensation in the lower limbs (HP:0002166)2.18924320
43Megalencephaly (HP:0001355)2.17223119
44Epileptic encephalopathy (HP:0200134)2.16388386
45Obsessive-compulsive behavior (HP:0000722)2.16002168
46Ankyloglossia (HP:0010296)2.14894322
47Deviation of the thumb (HP:0009603)2.13870576
48Overlapping toe (HP:0001845)2.13493888
49Broad distal phalanx of finger (HP:0009836)2.13486014
50Amyotrophic lateral sclerosis (HP:0007354)2.11804875
51Spinal cord lesions (HP:0100561)2.11323921
52Syringomyelia (HP:0003396)2.11323921
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11240154
54Patellar dislocation (HP:0002999)2.09798799
55Abnormality of the fingertips (HP:0001211)2.08664483
56Cerebral hypomyelination (HP:0006808)2.07924540
57Urinary urgency (HP:0000012)2.07394774
58Metaphyseal cupping (HP:0003021)2.07133816
59Poor eye contact (HP:0000817)2.07035665
60Impaired smooth pursuit (HP:0007772)2.04230845
61Aqueductal stenosis (HP:0002410)2.04156531
62Broad palm (HP:0001169)2.03093354
63Flat cornea (HP:0007720)2.02997367
64Amblyopia (HP:0000646)2.01867862
65Skull defect (HP:0001362)2.00520250
66Long eyelashes (HP:0000527)1.99878969
67Broad face (HP:0000283)1.98880561
68Anophthalmia (HP:0000528)1.96814626
69Medulloblastoma (HP:0002885)1.96402896
70Neoplasm of striated muscle (HP:0009728)1.96283320
71Sacral dimple (HP:0000960)1.96165917
72Abnormality of the diencephalon (HP:0010662)1.95013573
73Broad phalanges of the hand (HP:0009768)1.94287322
74Chromsome breakage (HP:0040012)1.92163101
75Abnormality of the calcaneus (HP:0008364)1.91790229
76Insidious onset (HP:0003587)1.90847348
77Termporal pattern (HP:0011008)1.90847348
78Urinary bladder sphincter dysfunction (HP:0002839)1.89841449
79Urethral obstruction (HP:0000796)1.89416478
80Impaired social interactions (HP:0000735)1.89159474
81Abnormal social behavior (HP:0012433)1.89159474
82Megalocornea (HP:0000485)1.88419073
83Neoplasm of the oral cavity (HP:0100649)1.85625674
84Leiomyosarcoma (HP:0100243)1.84443005
85Uterine leiomyosarcoma (HP:0002891)1.84443005
86Macroorchidism (HP:0000053)1.84182483
87Generalized hypotonia (HP:0001290)1.83351065
88Action tremor (HP:0002345)1.82964456
89Supranuclear gaze palsy (HP:0000605)1.81987795
90Broad finger (HP:0001500)1.81354401
91Deep philtrum (HP:0002002)1.80436967
92Diastasis recti (HP:0001540)1.80214056
93Attention deficit hyperactivity disorder (HP:0007018)1.79545407
94High anterior hairline (HP:0009890)1.79069067
95Depression (HP:0000716)1.78931950
96Broad alveolar ridges (HP:0000187)1.78631031
97Thin ribs (HP:0000883)1.78088743
98Intellectual disability, profound (HP:0002187)1.77830836
99Abnormality of the phalanges of the hallux (HP:0010057)1.77380199
100Missing ribs (HP:0000921)1.76630919
101Atresia of the external auditory canal (HP:0000413)1.75184758
102Partial duplication of thumb phalanx (HP:0009944)1.75045568
103Nephroblastoma (Wilms tumor) (HP:0002667)1.74940770
104Abnormality of the thoracic spine (HP:0100711)1.74742599
105Protrusio acetabuli (HP:0003179)1.73877506
106Heterotopia (HP:0002282)1.73628160
107Abnormality of ocular smooth pursuit (HP:0000617)1.73546420
108Rib fusion (HP:0000902)1.72943196
109Abnormality of the 4th metacarpal (HP:0010012)1.72259937
110Long palpebral fissure (HP:0000637)1.71770497
111Broad-based gait (HP:0002136)1.71719627
112Duplication of thumb phalanx (HP:0009942)1.70817641
113Reticulocytopenia (HP:0001896)1.70740747
114Spastic gait (HP:0002064)1.69911627
115Spastic diplegia (HP:0001264)1.69778599
116Genetic anticipation (HP:0003743)1.69599558
117Esophageal atresia (HP:0002032)1.69461430
118Hemiplegia (HP:0002301)1.69183855
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.68652891
120Abnormality of chromosome segregation (HP:0002916)1.68584468
121Fibroma (HP:0010614)1.67746245
122Malignant gastrointestinal tract tumors (HP:0006749)1.67441691
123Gastrointestinal carcinoma (HP:0002672)1.67441691
124Dysmetric saccades (HP:0000641)1.66549509
125Progressive cerebellar ataxia (HP:0002073)1.66520417
126Vertebral arch anomaly (HP:0008438)1.65880528
127Spina bifida occulta (HP:0003298)1.65807821
128Facial hemangioma (HP:0000329)1.64287263
129Achilles tendon contracture (HP:0001771)1.63920253
130Preauricular skin tag (HP:0000384)1.62910562
131Specific learning disability (HP:0001328)1.62832771
132Abnormality of oral frenula (HP:0000190)1.61222938
133Fibrous tissue neoplasm (HP:0012316)1.61173385
134Coronal craniosynostosis (HP:0004440)1.60846900
135Large earlobe (HP:0009748)1.60836691
136Abnormal large intestine physiology (HP:0012700)1.60809968
137Partial duplication of the phalanx of hand (HP:0009999)1.60678120
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60327345
139Shoulder girdle muscle weakness (HP:0003547)1.60027288
140Renal cell carcinoma (HP:0005584)1.59910779
141Resting tremor (HP:0002322)1.59642548
142Proximal placement of thumb (HP:0009623)1.59106299
143Dysdiadochokinesis (HP:0002075)1.58397465
144Relative macrocephaly (HP:0004482)1.57879698
145Deep palmar crease (HP:0006191)1.57672365
146Hemiparesis (HP:0001269)1.57647023
147Back pain (HP:0003418)1.57078966
148Progressive muscle weakness (HP:0003323)1.56998691
149Embryonal renal neoplasm (HP:0011794)1.56747373
150Precocious puberty (HP:0000826)1.56608151
151Flared metaphyses (HP:0003015)1.56531460
152Abnormality of the salivary glands (HP:0010286)1.56321244
153Hepatoblastoma (HP:0002884)1.54843210
154Short 1st metacarpal (HP:0010034)1.54753987
155Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.54753987
156Colon cancer (HP:0003003)1.54330269
157Bowel diverticulosis (HP:0005222)1.54111650
158Choanal stenosis (HP:0000452)1.53966112
159Dysphonia (HP:0001618)1.53333341
160Postural instability (HP:0002172)1.52945606
161Midface retrusion (HP:0011800)1.52737826
162Stereotypic behavior (HP:0000733)1.52544510
163Short phalanx of the thumb (HP:0009660)1.52083775
164Bowel incontinence (HP:0002607)1.51870032
165Bronchomalacia (HP:0002780)1.51745012
166Broad phalanx (HP:0006009)1.51407712
167Obstructive sleep apnea (HP:0002870)1.51281980
168Absent epiphyses (HP:0010577)1.51189803
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51189803
170Subacute progressive viral hepatitis (HP:0006572)1.50195218
171Skin tags (HP:0010609)1.50179572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.18219232
2MAP3K93.22682399
3EPHA43.10084412
4KSR12.90733612
5MARK12.68167759
6NTRK32.57019935
7TYRO32.46975464
8CDK122.45836223
9ICK2.35361778
10PRKD32.30724095
11FGFR42.27132205
12UHMK12.26540158
13PAK62.22611000
14NEK12.22271159
15MAP3K102.16602174
16MINK11.91555371
17SIK11.89850138
18NTRK21.85938698
19KSR21.84126222
20MAP3K41.76488450
21CDK191.70728115
22ALK1.64780417
23DAPK21.64219568
24CAMKK11.57057542
25ERN11.51689268
26EPHB21.51582113
27EEF2K1.51115250
28DAPK11.47668699
29CCNB11.46032777
30LATS21.37381057
31SIK21.35482094
32CDC71.33567705
33IRAK31.29245922
34PASK1.27500634
35CDK41.24244276
36CDK181.19362327
37TESK21.17036980
38RPS6KB21.16565301
39CDK151.14869889
40NME21.11758551
41PNCK1.11750432
42TAOK11.11395257
43CDK51.09072904
44CDK11A1.07135148
45BRD41.06234448
46CDK141.06123105
47TRIB31.05707431
48CAMK1D1.05400895
49BRAF1.04285283
50PDGFRA1.02666342
51CHEK21.02523623
52PRPF4B1.01745214
53PTK60.97449308
54MAP3K80.95982096
55MARK20.92447037
56SIK30.91935357
57TAF10.91098028
58FGFR20.90677327
59SCYL20.88868783
60PKN20.86003629
61CDK60.85856419
62NTRK10.85143304
63TTN0.83661325
64LATS10.81181068
65BRSK10.77685779
66PTK20.77612551
67NEK20.77560320
68FGFR10.77333368
69TSSK60.76462905
70BMX0.76162819
71ERBB20.74716193
72STK380.73328866
73CLK10.72153731
74STK110.70366464
75VRK20.68994751
76CDK90.67599247
77SRPK10.67479312
78DMPK0.67384785
79MAPK130.66648546
80PAK40.65398890
81CHEK10.64668369
82MAP2K40.64648227
83RIPK10.64568829
84DYRK20.64379103
85CDK20.63934903
86ARAF0.63562499
87BCR0.61444442
88MTOR0.61239984
89BUB10.60352932
90CAMK1G0.59881512
91CAMK40.59223999
92RPS6KL10.58872244
93RPS6KC10.58872244
94CSNK1E0.58754975
95AURKA0.58374161
96DDR20.58214623
97PRKCG0.57696453
98CDK70.57032714
99MAP2K70.56334805
100RET0.55641103
101EPHA20.55197901
102FGFR30.53858010
103MAPK100.53718284
104PHKG20.53377417
105PHKG10.53377417
106LRRK20.53094982
107MAP2K30.52689381
108MAPK110.52152756
109LIMK10.51689838
110CSNK1D0.51188999
111PAK30.50736195
112AKT20.50658354
113MAP2K20.48952000
114CSNK1G20.48320376
115ATR0.47970375
116CDK10.47913321
117DYRK30.46871885
118CDC42BPA0.45850624
119GSK3B0.45509041
120DYRK1A0.45375095
121RPS6KA20.44671034
122RPS6KA10.44273847
123AURKB0.44228244
124PLK10.44168026
125MAPK90.43252878
126MKNK10.43241403
127HIPK20.42889111
128MAP3K130.41425148
129RPS6KA30.41301933
130CDK80.41116706
131ROCK20.41031487
132ERBB30.40937589
133DAPK30.40185563
134NEK60.39226501
135ATM0.39113204
136MAP3K60.38680231
137AKT10.38649660
138CAMK10.38092153
139RAF10.37383922
140TTK0.36930518
141PAK20.36478349
142STK40.36342248
143MAP4K10.36192551
144SGK30.35864805
145WEE10.35853356
146DYRK1B0.35633699

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.09423662
2Olfactory transduction_Homo sapiens_hsa047402.07997946
3Nicotine addiction_Homo sapiens_hsa050332.06530096
4Long-term potentiation_Homo sapiens_hsa047201.96945096
5Circadian entrainment_Homo sapiens_hsa047131.82602449
6GABAergic synapse_Homo sapiens_hsa047271.77537182
7Dopaminergic synapse_Homo sapiens_hsa047281.77010080
8Glutamatergic synapse_Homo sapiens_hsa047241.74842611
9Oocyte meiosis_Homo sapiens_hsa041141.74076685
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71523806
11Morphine addiction_Homo sapiens_hsa050321.69592693
12Acute myeloid leukemia_Homo sapiens_hsa052211.68555861
13Axon guidance_Homo sapiens_hsa043601.67995569
14Pancreatic cancer_Homo sapiens_hsa052121.67416536
15Amphetamine addiction_Homo sapiens_hsa050311.65240587
16mRNA surveillance pathway_Homo sapiens_hsa030151.64008990
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63502236
18Basal cell carcinoma_Homo sapiens_hsa052171.60340648
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55721959
20Gap junction_Homo sapiens_hsa045401.53893513
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53627829
22Cocaine addiction_Homo sapiens_hsa050301.50899113
23Hippo signaling pathway_Homo sapiens_hsa043901.50768982
24Cholinergic synapse_Homo sapiens_hsa047251.48189810
25Lysine degradation_Homo sapiens_hsa003101.48122942
26Biosynthesis of amino acids_Homo sapiens_hsa012301.46170876
27Hedgehog signaling pathway_Homo sapiens_hsa043401.42927748
28Glioma_Homo sapiens_hsa052141.39645550
29Colorectal cancer_Homo sapiens_hsa052101.38644258
30mTOR signaling pathway_Homo sapiens_hsa041501.38482934
31Spliceosome_Homo sapiens_hsa030401.37775030
32Prostate cancer_Homo sapiens_hsa052151.37335953
33Oxytocin signaling pathway_Homo sapiens_hsa049211.36371111
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.36079865
35Notch signaling pathway_Homo sapiens_hsa043301.32251013
36Melanogenesis_Homo sapiens_hsa049161.31768921
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29200418
38ErbB signaling pathway_Homo sapiens_hsa040121.27803508
39Endometrial cancer_Homo sapiens_hsa052131.27228466
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26467356
41Wnt signaling pathway_Homo sapiens_hsa043101.24556265
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22295997
43Estrogen signaling pathway_Homo sapiens_hsa049151.21642019
44GnRH signaling pathway_Homo sapiens_hsa049121.18568607
45Small cell lung cancer_Homo sapiens_hsa052221.18412692
46Gastric acid secretion_Homo sapiens_hsa049711.18316830
47Insulin secretion_Homo sapiens_hsa049111.17983113
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.17762084
49Long-term depression_Homo sapiens_hsa047301.17544014
50Salivary secretion_Homo sapiens_hsa049701.14321795
51Pentose phosphate pathway_Homo sapiens_hsa000301.12330592
52Non-small cell lung cancer_Homo sapiens_hsa052231.12132215
53B cell receptor signaling pathway_Homo sapiens_hsa046621.12000428
54RNA transport_Homo sapiens_hsa030131.10680764
55Viral carcinogenesis_Homo sapiens_hsa052031.09182562
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08227166
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06656067
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05734469
59VEGF signaling pathway_Homo sapiens_hsa043701.04671268
60Renal cell carcinoma_Homo sapiens_hsa052111.01928041
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01158626
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99975270
63Alcoholism_Homo sapiens_hsa050340.98073483
64Hepatitis B_Homo sapiens_hsa051610.96329119
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95969387
66Type II diabetes mellitus_Homo sapiens_hsa049300.95216874
67Prion diseases_Homo sapiens_hsa050200.91707483
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.91509990
69Renin secretion_Homo sapiens_hsa049240.90789364
70Dorso-ventral axis formation_Homo sapiens_hsa043200.90749197
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.90507413
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.89995072
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89573483
74cAMP signaling pathway_Homo sapiens_hsa040240.89458737
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89362948
76Cell cycle_Homo sapiens_hsa041100.89313313
77Non-homologous end-joining_Homo sapiens_hsa034500.88384495
78AMPK signaling pathway_Homo sapiens_hsa041520.87716708
79Nucleotide excision repair_Homo sapiens_hsa034200.87409298
80Rap1 signaling pathway_Homo sapiens_hsa040150.85860674
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85389655
82MicroRNAs in cancer_Homo sapiens_hsa052060.84688715
83MAPK signaling pathway_Homo sapiens_hsa040100.84462972
84Calcium signaling pathway_Homo sapiens_hsa040200.83103012
85Chronic myeloid leukemia_Homo sapiens_hsa052200.81907614
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81760711
87Mismatch repair_Homo sapiens_hsa034300.81402659
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79462715
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79265037
90Focal adhesion_Homo sapiens_hsa045100.78998976
91Apoptosis_Homo sapiens_hsa042100.78192748
92Prolactin signaling pathway_Homo sapiens_hsa049170.77751567
93Serotonergic synapse_Homo sapiens_hsa047260.77672803
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77391446
95Choline metabolism in cancer_Homo sapiens_hsa052310.76373242
96Tight junction_Homo sapiens_hsa045300.76342152
97DNA replication_Homo sapiens_hsa030300.75633039
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75157996
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75077719
100Other glycan degradation_Homo sapiens_hsa005110.75070220
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74538956
102Melanoma_Homo sapiens_hsa052180.73095832
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72996263
104p53 signaling pathway_Homo sapiens_hsa041150.72745564
105Taste transduction_Homo sapiens_hsa047420.72246400
106One carbon pool by folate_Homo sapiens_hsa006700.70591362
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69864942
108Proteoglycans in cancer_Homo sapiens_hsa052050.68735588
109Shigellosis_Homo sapiens_hsa051310.68538263
110Epstein-Barr virus infection_Homo sapiens_hsa051690.68428850
111Carbon metabolism_Homo sapiens_hsa012000.67866630
112Dilated cardiomyopathy_Homo sapiens_hsa054140.67798760
113Ribosome_Homo sapiens_hsa030100.67415877
114Thyroid cancer_Homo sapiens_hsa052160.67305845
115Endocytosis_Homo sapiens_hsa041440.67261528
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66259747
117Adherens junction_Homo sapiens_hsa045200.65655983
118Hepatitis C_Homo sapiens_hsa051600.63859391
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63437905
120Bladder cancer_Homo sapiens_hsa052190.60771377
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60243805
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60140956
123Base excision repair_Homo sapiens_hsa034100.58657743
124N-Glycan biosynthesis_Homo sapiens_hsa005100.58609544
125Pathways in cancer_Homo sapiens_hsa052000.57880686
126HTLV-I infection_Homo sapiens_hsa051660.57689348
127Ras signaling pathway_Homo sapiens_hsa040140.57576982
128Fructose and mannose metabolism_Homo sapiens_hsa000510.57320451
129Herpes simplex infection_Homo sapiens_hsa051680.56944800
130FoxO signaling pathway_Homo sapiens_hsa040680.56662691
131Nitrogen metabolism_Homo sapiens_hsa009100.56641539
132Insulin signaling pathway_Homo sapiens_hsa049100.55457082
133Sulfur relay system_Homo sapiens_hsa041220.55127417
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54182283
135HIF-1 signaling pathway_Homo sapiens_hsa040660.54029112
136Galactose metabolism_Homo sapiens_hsa000520.53553042
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.52076443
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.50973081
139T cell receptor signaling pathway_Homo sapiens_hsa046600.49735320
140Inositol phosphate metabolism_Homo sapiens_hsa005620.46916638
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46827756
142Glucagon signaling pathway_Homo sapiens_hsa049220.46705918

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