SMARCD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.05033029
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05033029
3COPI coating of Golgi vesicle (GO:0048205)4.67612268
4Golgi transport vesicle coating (GO:0048200)4.67612268
5antigen processing and presentation of endogenous antigen (GO:0019883)4.57683869
6positive regulation of gamma-delta T cell activation (GO:0046645)4.46473025
7proline biosynthetic process (GO:0006561)4.30843318
8positive regulation of Cdc42 GTPase activity (GO:0043089)4.26618335
9regulation of gamma-delta T cell differentiation (GO:0045586)4.06422549
10positive regulation of keratinocyte differentiation (GO:0045618)3.80177174
11regulation of mammary gland epithelial cell proliferation (GO:0033599)3.79202591
12regulation of gamma-delta T cell activation (GO:0046643)3.73661364
13ribosomal small subunit assembly (GO:0000028)3.67965585
14epithelial cell differentiation involved in prostate gland development (GO:0060742)3.37361654
15regulation of histone H3-K27 methylation (GO:0061085)3.34418825
16negative regulation of cell size (GO:0045792)3.34300606
17viral transcription (GO:0019083)3.32252369
18regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.27348586
19positive regulation of B cell differentiation (GO:0045579)3.27271032
20spliceosomal tri-snRNP complex assembly (GO:0000244)3.26094320
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.25090775
22regulation of translational fidelity (GO:0006450)3.24681519
23translational termination (GO:0006415)3.19353878
24glucose catabolic process (GO:0006007)3.18965202
25embryonic process involved in female pregnancy (GO:0060136)3.17278768
26DNA unwinding involved in DNA replication (GO:0006268)3.10091635
27pinocytosis (GO:0006907)3.06173015
28peptidyl-arginine omega-N-methylation (GO:0035247)3.00375401
29cell-substrate adherens junction assembly (GO:0007045)2.97153639
30focal adhesion assembly (GO:0048041)2.97153639
31activation of Rac GTPase activity (GO:0032863)2.96179691
32translational elongation (GO:0006414)2.94783578
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94578680
34glucose 6-phosphate metabolic process (GO:0051156)2.93782444
35desmosome organization (GO:0002934)2.92818771
36regulation of glucose import in response to insulin stimulus (GO:2001273)2.91973058
37apoptotic process involved in morphogenesis (GO:0060561)2.90961821
38adherens junction assembly (GO:0034333)2.89789706
39dosage compensation (GO:0007549)2.88638651
40branching involved in mammary gland duct morphogenesis (GO:0060444)2.88030973
41proline metabolic process (GO:0006560)2.87450720
42trophectodermal cell differentiation (GO:0001829)2.86246135
43antigen processing and presentation via MHC class Ib (GO:0002475)2.84214196
44positive regulation of epidermal cell differentiation (GO:0045606)2.83012116
45protein retention in ER lumen (GO:0006621)2.81326935
46negative regulation of erythrocyte differentiation (GO:0045647)2.78790361
47nuclear pore complex assembly (GO:0051292)2.78599391
48mannose metabolic process (GO:0006013)2.75903107
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.75780777
50folic acid-containing compound biosynthetic process (GO:0009396)2.75640868
51intracellular estrogen receptor signaling pathway (GO:0030520)2.75430806
52hepatocyte apoptotic process (GO:0097284)2.75226806
53pentose-phosphate shunt (GO:0006098)2.74990777
54negative regulation of phagocytosis (GO:0050765)2.72334400
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.72141144
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.69918708
57positive thymic T cell selection (GO:0045059)2.68994438
58regulation of water loss via skin (GO:0033561)2.68690624
593-UTR-mediated mRNA stabilization (GO:0070935)2.67924990
60positive regulation of histone deacetylation (GO:0031065)2.67818432
61SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67355183
62regulation of B cell differentiation (GO:0045577)2.66368260
63NADH metabolic process (GO:0006734)2.65344964
64protein localization to endosome (GO:0036010)2.65238501
65Arp2/3 complex-mediated actin nucleation (GO:0034314)2.65143059
66Peyers patch development (GO:0048541)2.64729421
67mucosal-associated lymphoid tissue development (GO:0048537)2.64729421
68negative regulation of viral release from host cell (GO:1902187)2.64470970
69protein localization to kinetochore (GO:0034501)2.63327720
70modulation by symbiont of host cellular process (GO:0044068)2.62327188
71embryonic eye morphogenesis (GO:0048048)2.62003921
72modulation by virus of host process (GO:0019054)2.60363180
73DNA strand elongation involved in DNA replication (GO:0006271)2.59912489
74amyloid precursor protein catabolic process (GO:0042987)2.59455293
75valine metabolic process (GO:0006573)2.58804534
76protein targeting to ER (GO:0045047)2.58416751
77cotranslational protein targeting to membrane (GO:0006613)2.55970168
78cellular response to epidermal growth factor stimulus (GO:0071364)2.54547567
79glycine metabolic process (GO:0006544)2.54376274
80translational initiation (GO:0006413)2.53195966
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.51047765
82positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.49927737
83DNA strand elongation (GO:0022616)2.47910657
84maturation of SSU-rRNA (GO:0030490)2.46190565
85establishment of protein localization to endoplasmic reticulum (GO:0072599)2.45426745
86protein localization to chromosome, centromeric region (GO:0071459)2.44950677
87formation of translation preinitiation complex (GO:0001731)2.44690593
88viral life cycle (GO:0019058)2.44278015
89GDP-mannose metabolic process (GO:0019673)2.44052603
90regulation of early endosome to late endosome transport (GO:2000641)2.43619226
91protein complex localization (GO:0031503)2.42598756
92positive regulation of protein deacetylation (GO:0090312)2.40666506
93protein localization to endoplasmic reticulum (GO:0070972)2.40330103
94activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.39294862
95natural killer cell differentiation (GO:0001779)2.39089159
96ribosomal small subunit biogenesis (GO:0042274)2.38342564
97NADPH regeneration (GO:0006740)2.37529178
98positive regulation of nuclease activity (GO:0032075)2.36869952
99regulation of fatty acid beta-oxidation (GO:0031998)2.36525297
100mitotic chromosome condensation (GO:0007076)2.35849340
101response to peptidoglycan (GO:0032494)2.35214514
102telomere maintenance via semi-conservative replication (GO:0032201)2.35031112
103regulation of RNA export from nucleus (GO:0046831)2.34831437
104peptidyl-arginine methylation (GO:0018216)2.34277806
105peptidyl-arginine N-methylation (GO:0035246)2.34277806
106negative regulation of fatty acid transport (GO:2000192)2.34221585
107pentose metabolic process (GO:0019321)2.33951760
108T cell homeostasis (GO:0043029)2.33927485
109V(D)J recombination (GO:0033151)2.33465674
110epithelial cell-cell adhesion (GO:0090136)2.31341530
111cellular protein complex disassembly (GO:0043624)2.31029439
112regulation of interleukin-12 biosynthetic process (GO:0045075)2.29035743
113B cell receptor signaling pathway (GO:0050853)2.28610185
114cellular hyperosmotic response (GO:0071474)2.28541874
115cellular response to virus (GO:0098586)2.28211222
116regulation of nucleobase-containing compound transport (GO:0032239)2.28202083
117mitotic G1 DNA damage checkpoint (GO:0031571)2.26809688
118protein export from nucleus (GO:0006611)2.25365829
119histone arginine methylation (GO:0034969)2.23344852
120embryonic camera-type eye morphogenesis (GO:0048596)2.23247367
121translesion synthesis (GO:0019985)2.22037175
122regulation of defense response to virus by virus (GO:0050690)2.21346632
123cell-substrate junction assembly (GO:0007044)2.20251258
124cellular protein complex localization (GO:0034629)2.20181773
125negative regulation of RNA splicing (GO:0033119)2.19627285
126glutamine family amino acid biosynthetic process (GO:0009084)2.19559361
127histone H3-K36 demethylation (GO:0070544)2.19356293
128nucleobase-containing small molecule interconversion (GO:0015949)2.19022214
129regulation of nuclease activity (GO:0032069)2.18900398
130regulation of type I interferon-mediated signaling pathway (GO:0060338)2.18836362
131endoplasmic reticulum unfolded protein response (GO:0030968)2.18196218
132viral mRNA export from host cell nucleus (GO:0046784)2.17600769
133NIK/NF-kappaB signaling (GO:0038061)2.17052497
134DNA deamination (GO:0045006)2.16674980
135mitotic nuclear envelope disassembly (GO:0007077)2.16668739
136mitotic recombination (GO:0006312)2.16584683
137ER-nucleus signaling pathway (GO:0006984)2.16522694
138modulation by virus of host morphology or physiology (GO:0019048)2.16486934
139nuclear pore organization (GO:0006999)2.16482220
140positive regulation of epidermis development (GO:0045684)2.16339031
141thymic T cell selection (GO:0045061)2.15904910
142regulation of histone H3-K9 methylation (GO:0051570)2.15581023
143response to laminar fluid shear stress (GO:0034616)2.14721713
144* protein complex disassembly (GO:0043241)2.14660125
145DNA duplex unwinding (GO:0032508)2.14087560
146nuclear-transcribed mRNA catabolic process (GO:0000956)2.13932039
147regulation of chromatin binding (GO:0035561)2.13120423
148positive T cell selection (GO:0043368)2.12709433
149maternal placenta development (GO:0001893)2.11921372
150T cell apoptotic process (GO:0070231)2.11595228
151DNA geometric change (GO:0032392)2.11543634
152cellular response to interleukin-4 (GO:0071353)2.11313400
153regulation of response to interferon-gamma (GO:0060330)2.11247199
154telomere maintenance via recombination (GO:0000722)2.11206052
155regulation of superoxide anion generation (GO:0032928)2.08141402
156JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.07528002
157immunoglobulin mediated immune response (GO:0016064)2.07166718
158negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.07014319
159mitotic sister chromatid cohesion (GO:0007064)2.06757279
160citrulline biosynthetic process (GO:0019240)2.06460636
161mRNA catabolic process (GO:0006402)2.06165252
162negative T cell selection (GO:0043383)2.06043242
163DNA replication initiation (GO:0006270)2.05871890
164positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.05745652
165folic acid metabolic process (GO:0046655)2.05000180
166T cell selection (GO:0045058)2.04790712
167mRNA stabilization (GO:0048255)2.04220760
168RNA stabilization (GO:0043489)2.04220760
169RNA catabolic process (GO:0006401)2.03029653
170regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.02694158
171urea metabolic process (GO:0019627)2.02560550
172urea cycle (GO:0000050)2.02560550
173antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.02510204
174definitive hemopoiesis (GO:0060216)2.02309931
175negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.02113772
176negative regulation of histone methylation (GO:0031061)2.01708489
177regulation of B cell receptor signaling pathway (GO:0050855)2.01070253
178fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.01026293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.00072469
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.26409055
3MYC_22102868_ChIP-Seq_BL_Human3.19848942
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.75059930
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71686748
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.65277829
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.63520210
8VDR_21846776_ChIP-Seq_THP-1_Human2.45248143
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16260616
10LXR_22292898_ChIP-Seq_THP-1_Human2.10961218
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06544883
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.00576734
13E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99147011
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97683889
15* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96948845
16* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93891458
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91320947
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89354395
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.87317954
20MAF_26560356_Chip-Seq_TH1_Human1.84868420
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.83174041
22* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82101834
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80893708
24SCL_19346495_ChIP-Seq_HPC-7_Human1.78329618
25TCF7_22412390_ChIP-Seq_EML_Mouse1.74101752
26UTX_26944678_Chip-Seq_JUKART_Human1.72922874
27MYB_26560356_Chip-Seq_TH2_Human1.70996758
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69224517
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69205997
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67502908
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64316522
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63954683
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63935024
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63925909
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61266884
36* MYB_26560356_Chip-Seq_TH1_Human1.60422742
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59386546
38* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58643012
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58525172
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56926715
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.54719010
42VDR_24763502_ChIP-Seq_THP-1_Human1.53423831
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.53190433
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49592241
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48050341
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47827983
47* SPI1_23547873_ChIP-Seq_NB4_Human1.47257201
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46328148
49* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44323927
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42924069
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.41993492
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41973835
53* CIITA_25753668_ChIP-Seq_RAJI_Human1.41536284
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.41412480
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41118633
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40912178
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39749685
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39420534
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38058678
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37482532
61* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37127551
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36988534
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.36581186
64* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36431435
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34713409
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34429089
67* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33059244
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32875824
69XRN2_22483619_ChIP-Seq_HELA_Human1.32549579
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32361708
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.31762282
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.31231477
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30682164
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30640616
75AR_21909140_ChIP-Seq_LNCAP_Human1.30344041
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28165034
77* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27756902
78MAF_26560356_Chip-Seq_TH2_Human1.27200925
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26694057
80KDM5A_27292631_Chip-Seq_BREAST_Human1.25887005
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25187708
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25135436
83* FOXP3_21729870_ChIP-Seq_TREG_Human1.25134733
84* VDR_23849224_ChIP-Seq_CD4+_Human1.24129792
85ATF3_27146783_Chip-Seq_COLON_Human1.23939764
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23774530
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.23517387
88P68_20966046_ChIP-Seq_HELA_Human1.23176658
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23035784
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22874706
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22602811
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.21977418
93GATA1_22025678_ChIP-Seq_K562_Human1.19563961
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19263370
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18605479
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18603555
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18549993
98CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16869754
99* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16012745
100STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15902598
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15826004
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.14134099
103ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13761392
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12642459
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12208878
106KDM2B_26808549_Chip-Seq_K562_Human1.12188067
107KDM2B_26808549_Chip-Seq_DND41_Human1.12187568
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.11664592
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11033390
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09614734
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09019260
112* SA1_27219007_Chip-Seq_ERYTHROID_Human1.08462929
113ZNF263_19887448_ChIP-Seq_K562_Human1.08287046
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07183713
115CREB1_26743006_Chip-Seq_LNCaP_Human1.07015658
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05760602
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04966962
118SMC4_20622854_ChIP-Seq_HELA_Human1.04958079
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04805103
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04303419
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04209078
122RUNX_20019798_ChIP-Seq_JUKART_Human1.04048042
123* NCOR1_26117541_ChIP-Seq_K562_Human1.03745280
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00485885
125EST1_17652178_ChIP-ChIP_JURKAT_Human1.00274026
126KDM2B_26808549_Chip-Seq_JURKAT_Human1.00259385
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00108408
128ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99971707
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99748454
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98598552
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.98345242
132ETS1_20019798_ChIP-Seq_JURKAT_Human0.97381861
133* GABP_19822575_ChIP-Seq_HepG2_Human0.96530904
134GATA3_27048872_Chip-Seq_THYMUS_Human0.96490317
135STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96292224
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95315195
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95099488
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94946896
139CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93541288
140DCP1A_22483619_ChIP-Seq_HELA_Human0.92984521
141* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91901525
142* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91706302
143CLOCK_20551151_ChIP-Seq_293T_Human0.91362516
144SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89481815
145RACK7_27058665_Chip-Seq_MCF-7_Human0.89422619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.23514793
2MP0000685_abnormal_immune_system2.50245552
3MP0002396_abnormal_hematopoietic_system2.48184488
4MP0005058_abnormal_lysosome_morphology2.46016845
5MP0004185_abnormal_adipocyte_glucose2.42378014
6MP0003763_abnormal_thymus_physiology2.39639235
7MP0001835_abnormal_antigen_presentation2.37817318
8MP0005360_urolithiasis2.28820660
9MP0002139_abnormal_hepatobiliary_system2.13334507
10MP0008260_abnormal_autophagy2.11171266
11MP0003693_abnormal_embryo_hatching2.07924218
12MP0002166_altered_tumor_susceptibility2.06494699
13MP0001800_abnormal_humoral_immune1.98782542
14MP0010352_gastrointestinal_tract_polyps1.94449011
15MP0003300_gastrointestinal_ulcer1.89467742
16MP0003705_abnormal_hypodermis_morpholog1.83635249
17MP0010094_abnormal_chromosome_stability1.83527881
18MP0002398_abnormal_bone_marrow1.81065141
19MP0005365_abnormal_bile_salt1.80722973
20MP0003436_decreased_susceptibility_to1.79715189
21MP0009278_abnormal_bone_marrow1.76013721
22MP0005387_immune_system_phenotype1.73915978
23MP0001790_abnormal_immune_system1.73915978
24MP0009840_abnormal_foam_cell1.73804194
25MP0000490_abnormal_crypts_of1.70424363
26MP0004381_abnormal_hair_follicle1.69992990
27MP0001545_abnormal_hematopoietic_system1.69118555
28MP0005397_hematopoietic_system_phenotyp1.69118555
29MP0004233_abnormal_muscle_weight1.67334916
30MP0010155_abnormal_intestine_physiology1.64336531
31MP0005671_abnormal_response_to1.63825752
32MP0004808_abnormal_hematopoietic_stem1.63734985
33MP0002452_abnormal_antigen_presenting1.63391529
34MP0000689_abnormal_spleen_morphology1.61339410
35MP0009785_altered_susceptibility_to1.59016852
36MP0002722_abnormal_immune_system1.58116014
37MP0009333_abnormal_splenocyte_physiolog1.56643847
38MP0003111_abnormal_nucleus_morphology1.55415279
39MP0002420_abnormal_adaptive_immunity1.55141107
40MP0003191_abnormal_cellular_cholesterol1.53862839
41MP0001819_abnormal_immune_cell1.52837089
42MP0005025_abnormal_response_to1.52150549
43MP0004947_skin_inflammation1.52029425
44MP0001873_stomach_inflammation1.51710064
45MP0004957_abnormal_blastocyst_morpholog1.51354844
46MP0000716_abnormal_immune_system1.50669759
47MP0002723_abnormal_immune_serum1.50279439
48MP0002006_tumorigenesis1.49751565
49MP0003303_peritoneal_inflammation1.49647804
50MP0003077_abnormal_cell_cycle1.49117767
51MP0000703_abnormal_thymus_morphology1.48295713
52MP0005085_abnormal_gallbladder_physiolo1.48216145
53MP0005464_abnormal_platelet_physiology1.47471379
54MP0002098_abnormal_vibrissa_morphology1.46291222
55MP0005409_darkened_coat_color1.46101487
56MP0002429_abnormal_blood_cell1.38329424
57MP0005000_abnormal_immune_tolerance1.37243386
58MP0004858_abnormal_nervous_system1.36798609
59MP0002405_respiratory_system_inflammati1.34958797
60MP0005666_abnormal_adipose_tissue1.34851327
61MP0003806_abnormal_nucleotide_metabolis1.34596407
62MP0006054_spinal_hemorrhage1.31742734
63MP0002138_abnormal_hepatobiliary_system1.29594584
64MP0000465_gastrointestinal_hemorrhage1.28765192
65MP0002019_abnormal_tumor_incidence1.26811508
66MP0002132_abnormal_respiratory_system1.25773401
67MP0002009_preneoplasia1.24391745
68MP0010234_abnormal_vibrissa_follicle1.23316951
69MP0000678_abnormal_parathyroid_gland1.22843297
70MP0008007_abnormal_cellular_replicative1.22679679
71MP0000609_abnormal_liver_physiology1.22094268
72MP0001845_abnormal_inflammatory_respons1.20311743
73MP0000537_abnormal_urethra_morphology1.20169828
74MP0004782_abnormal_surfactant_physiolog1.18810499
75MP0009672_abnormal_birth_weight1.18608763
76MP0002419_abnormal_innate_immunity1.18558302
77MP0001666_abnormal_nutrient_absorption1.16745300
78MP0003252_abnormal_bile_duct1.15035881
79MP0001853_heart_inflammation1.14990084
80MP0003866_abnormal_defecation1.13317455
81MP0010307_abnormal_tumor_latency1.11646019
82MP0010329_abnormal_lipoprotein_level1.10323976
83MP0003172_abnormal_lysosome_physiology1.09961208
84MP0008875_abnormal_xenobiotic_pharmacok1.09895106
85MP0001881_abnormal_mammary_gland1.06727885
86MP0000627_abnormal_mammary_gland1.06623929
87MP0005076_abnormal_cell_differentiation1.03629531
88MP0008057_abnormal_DNA_replication1.03189876
89MP0002089_abnormal_postnatal_growth/wei1.02655227
90MP0005375_adipose_tissue_phenotype1.01389122
91MP0003123_paternal_imprinting0.99982925
92MP0002080_prenatal_lethality0.98649482
93MP0008058_abnormal_DNA_repair0.98030551
94MP0000350_abnormal_cell_proliferation0.97430209
95MP0003566_abnormal_cell_adhesion0.96415987
96MP0000598_abnormal_liver_morphology0.95778306
97MP0008469_abnormal_protein_level0.94745737
98MP0002060_abnormal_skin_morphology0.93826675
99MP0000858_altered_metastatic_potential0.93803083
100MP0003453_abnormal_keratinocyte_physiol0.93731648
101MP0004264_abnormal_extraembryonic_tissu0.93166200
102MP0005621_abnormal_cell_physiology0.93065083
103MP0001730_embryonic_growth_arrest0.92939564
104MP0005023_abnormal_wound_healing0.91976516
105MP0005083_abnormal_biliary_tract0.91842863
106MP0000313_abnormal_cell_death0.90958908
107MP0002877_abnormal_melanocyte_morpholog0.89717073
108MP0001727_abnormal_embryo_implantation0.89252962
109MP0000477_abnormal_intestine_morphology0.88943728
110MP0001672_abnormal_embryogenesis/_devel0.88666763
111MP0005380_embryogenesis_phenotype0.88666763
112MP0003984_embryonic_growth_retardation0.88619914
113MP0008438_abnormal_cutaneous_collagen0.88425729
114MP0002254_reproductive_system_inflammat0.88257192
115MP0003183_abnormal_peptide_metabolism0.86073427
116MP0001849_ear_inflammation0.86015256
117MP0000003_abnormal_adipose_tissue0.85443793
118MP0002088_abnormal_embryonic_growth/wei0.85211121
119MP0001216_abnormal_epidermal_layer0.84692133
120MP0000462_abnormal_digestive_system0.83647541
121MP0009931_abnormal_skin_appearance0.82878880
122MP0010678_abnormal_skin_adnexa0.81493424
123MP0001348_abnormal_lacrimal_gland0.81417360
124MP0003091_abnormal_cell_migration0.81221300
125MP0006082_CNS_inflammation0.80570968
126MP0002148_abnormal_hypersensitivity_rea0.80372108
127MP0005220_abnormal_exocrine_pancreas0.79860414
128MP0009763_increased_sensitivity_to0.79243519
129MP0002249_abnormal_larynx_morphology0.77677355
130MP0005319_abnormal_enzyme/_coenzyme0.75974873
131MP0000377_abnormal_hair_follicle0.75261595
132MP0001661_extended_life_span0.74969541
133MP0001697_abnormal_embryo_size0.74884429
134MP0005075_abnormal_melanosome_morpholog0.74809141
135MP0003656_abnormal_erythrocyte_physiolo0.74783466
136MP0009643_abnormal_urine_homeostasis0.74408624
137MP0000467_abnormal_esophagus_morphology0.73937267
138MP0003221_abnormal_cardiomyocyte_apopto0.73612201
139MP0008932_abnormal_embryonic_tissue0.73211531
140MP0002086_abnormal_extraembryonic_tissu0.71746028
141MP0005501_abnormal_skin_physiology0.71725842
142MP0002796_impaired_skin_barrier0.71151849

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)3.70887133
2Recurrent viral infections (HP:0004429)3.65049651
3Thrombocytosis (HP:0001894)3.62199292
4Panhypogammaglobulinemia (HP:0003139)3.33693981
5IgM deficiency (HP:0002850)3.32763303
6Recurrent bronchitis (HP:0002837)3.24644033
7Chronic otitis media (HP:0000389)3.19144089
8B lymphocytopenia (HP:0010976)3.14521501
9Abnormality of B cell number (HP:0010975)3.14521501
10Recurrent fungal infections (HP:0002841)3.03814885
11T lymphocytopenia (HP:0005403)3.03233960
12Abnormality of cells of the erythroid lineage (HP:0012130)3.02867349
13Abnormal delayed hypersensitivity skin test (HP:0002963)2.97246393
14Abnormal number of erythroid precursors (HP:0012131)2.94378914
15Abnormality of the fingertips (HP:0001211)2.93378306
16Cellulitis (HP:0100658)2.90234295
17Nasal polyposis (HP:0100582)2.88426237
18Abnormality of T cells (HP:0002843)2.88223441
19Abnormality of T cell number (HP:0011839)2.82563164
20Flat acetabular roof (HP:0003180)2.81778104
21Gastrointestinal inflammation (HP:0004386)2.80999180
22Agammaglobulinemia (HP:0004432)2.75309578
23Abnormality of the nasal mucosa (HP:0000433)2.75304296
24J-shaped sella turcica (HP:0002680)2.73803318
25Inflammation of the large intestine (HP:0002037)2.73654736
26Colitis (HP:0002583)2.71649195
27Micronodular cirrhosis (HP:0001413)2.69330510
28Abnormality of T cell physiology (HP:0011840)2.68843403
29Papilloma (HP:0012740)2.68404779
30Verrucae (HP:0200043)2.68404779
31Spontaneous hematomas (HP:0007420)2.63393736
32Elevated erythrocyte sedimentation rate (HP:0003565)2.63333277
33Thin bony cortex (HP:0002753)2.60309084
34Deep venous thrombosis (HP:0002625)2.60184563
35Septate vagina (HP:0001153)2.59331548
36Pustule (HP:0200039)2.56073449
37Hypoplasia of the thymus (HP:0000778)2.51623785
38Combined immunodeficiency (HP:0005387)2.50870034
39Meningitis (HP:0001287)2.41184879
40Distal lower limb muscle weakness (HP:0009053)2.37912560
41Autoimmune thrombocytopenia (HP:0001973)2.34761273
42Thyroiditis (HP:0100646)2.32973530
43Vertebral compression fractures (HP:0002953)2.32280823
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30998541
45Increased IgE level (HP:0003212)2.30254380
46Myositis (HP:0100614)2.29391497
47Eczematoid dermatitis (HP:0000976)2.28407746
48Severe combined immunodeficiency (HP:0004430)2.28235070
49Germ cell neoplasia (HP:0100728)2.27187104
50Abnormal platelet function (HP:0011869)2.26375363
51Impaired platelet aggregation (HP:0003540)2.26375363
52Cholecystitis (HP:0001082)2.25863717
53Abnormal gallbladder physiology (HP:0012438)2.25863717
54Hypochromic anemia (HP:0001931)2.25827215
55Reticulocytopenia (HP:0001896)2.21656953
56Reticulocytosis (HP:0001923)2.21276303
57Sparse lateral eyebrow (HP:0005338)2.20970819
58Recurrent bacterial skin infections (HP:0005406)2.20206464
59Progressive muscle weakness (HP:0003323)2.19870342
60Achilles tendon contracture (HP:0001771)2.18100876
61Abnormal platelet volume (HP:0011876)2.17933780
62Recurrent cutaneous fungal infections (HP:0011370)2.17337948
63Chronic mucocutaneous candidiasis (HP:0002728)2.17337948
64Interstitial pulmonary disease (HP:0006530)2.17337237
65Eosinophilia (HP:0001880)2.16464179
66Hypobetalipoproteinemia (HP:0003563)2.14414677
67Ragged-red muscle fibers (HP:0003200)2.13065972
68Syringomyelia (HP:0003396)2.12665237
69Spinal cord lesions (HP:0100561)2.12665237
70Epistaxis (HP:0000421)2.11182794
71Granulocytopenia (HP:0001913)2.11061582
72Broad face (HP:0000283)2.09609647
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.08893981
74Petechiae (HP:0000967)2.07431694
75Hyperparathyroidism (HP:0000843)2.07027084
76Lymphopenia (HP:0001888)2.07015286
77Progressive external ophthalmoplegia (HP:0000590)2.06669004
78Hemorrhage of the eye (HP:0011885)2.04791149
79Gingival bleeding (HP:0000225)2.03997957
80Prolonged bleeding time (HP:0003010)2.03964514
81Basal cell carcinoma (HP:0002671)2.03241240
82IgG deficiency (HP:0004315)2.02282277
83Hematochezia (HP:0002573)2.01971959
84Recurrent abscess formation (HP:0002722)2.01282516
85Recurrent skin infections (HP:0001581)2.00362043
86Abnormality of the Achilles tendon (HP:0005109)1.98819580
87Abnormality of the distal phalanges of the toes (HP:0010182)1.96565663
88Abdominal distention (HP:0003270)1.96343988
89Spastic diplegia (HP:0001264)1.94438624
90Periodontitis (HP:0000704)1.94052972
91Skin ulcer (HP:0200042)1.92957643
92Pili torti (HP:0003777)1.92817749
93Long palpebral fissure (HP:0000637)1.91161155
94Cerebral aneurysm (HP:0004944)1.91123329
95Spinal cord compression (HP:0002176)1.90569160
96Hyperacusis (HP:0010780)1.90367681
97Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89251129
98Recurrent gram-negative bacterial infections (HP:0005420)1.89114868
99Centrally nucleated skeletal muscle fibers (HP:0003687)1.88999320
100Lymphoma (HP:0002665)1.88996543
101Microcytic anemia (HP:0001935)1.88885127
102Bronchitis (HP:0012387)1.88874287
103Recurrent sinusitis (HP:0011108)1.88506390
104Trismus (HP:0000211)1.87581241
105Intrahepatic cholestasis (HP:0001406)1.86583415
106Distal lower limb amyotrophy (HP:0008944)1.86363209
107Polygenic inheritance (HP:0010982)1.85364811
108Abnormality of the distal phalanx of the thumb (HP:0009617)1.85235060
109Abnormality of reticulocytes (HP:0004312)1.84892470
110Esophageal varix (HP:0002040)1.84594487
111IgA deficiency (HP:0002720)1.83025233
112Xanthomatosis (HP:0000991)1.81834692
113Increased mean platelet volume (HP:0011877)1.81367371
114Myocardial infarction (HP:0001658)1.81041785
115Increased cerebral lipofuscin (HP:0011813)1.80832316
116Disproportionate tall stature (HP:0001519)1.79721711
117Selective tooth agenesis (HP:0001592)1.78220816
118Poikiloderma (HP:0001029)1.78210149
119Osteomyelitis (HP:0002754)1.78092885
120Increased connective tissue (HP:0009025)1.77011235
121Vasculitis (HP:0002633)1.76581345
122Advanced eruption of teeth (HP:0006288)1.76529457
123Testicular neoplasm (HP:0010788)1.76528887
124Abnormality of the umbilical cord (HP:0010881)1.75409148
125Protrusio acetabuli (HP:0003179)1.75054619
126Ankyloglossia (HP:0010296)1.74904557
127Back pain (HP:0003418)1.74318630
128Seborrheic dermatitis (HP:0001051)1.74088064
129Joint hemorrhage (HP:0005261)1.73730429
130Deformed sella turcica (HP:0002681)1.73424546
131Dysmetric saccades (HP:0000641)1.73126355
132Microglossia (HP:0000171)1.72804569
133Abnormality of eosinophils (HP:0001879)1.72647482
134Bone pain (HP:0002653)1.72058025
135Broad distal phalanx of finger (HP:0009836)1.71986154
136Arterial thrombosis (HP:0004420)1.71137035
137Leukocytosis (HP:0001974)1.70890889
138Encephalitis (HP:0002383)1.70702631
139Fatigue (HP:0012378)1.70399685
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.70186324
141Polycythemia (HP:0001901)1.70117126
142Increased serum ferritin (HP:0003281)1.69880343
143Abnormality of macrophages (HP:0004311)1.69431407
144Abnormality of the common coagulation pathway (HP:0010990)1.69238251
145Increased neuronal autofluorescent lipopigment (HP:0002074)1.68942367
146Abnormality of pyrimidine metabolism (HP:0004353)1.68822786
147Insomnia (HP:0100785)1.68382220
148Premature skin wrinkling (HP:0100678)1.67829029
149Macrocytic anemia (HP:0001972)1.67763977
150Metaphyseal cupping (HP:0003021)1.67211751
151Ulnar bowing (HP:0003031)1.67030816
152Hypercortisolism (HP:0001578)1.66955529
153Dysostosis multiplex (HP:0000943)1.66535726
154Gastrointestinal stroma tumor (HP:0100723)1.65205599
155Aplastic anemia (HP:0001915)1.65202808
156Prominent nose (HP:0000448)1.64883356
157Hepatitis (HP:0012115)1.64049940
158Cervical subluxation (HP:0003308)1.62988056
159Skin rash (HP:0000988)1.62761234
160Thoracic kyphosis (HP:0002942)1.62166365
161Chronic sinusitis (HP:0011109)1.62070496
162Thrombophlebitis (HP:0004418)1.62040801
163Complement deficiency (HP:0004431)1.61968882
164Abnormality of the thoracic spine (HP:0100711)1.61947413
165Abnormality of oral frenula (HP:0000190)1.61551998
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.61430433
167Osteolytic defects of the hand bones (HP:0009699)1.61430433
168Insidious onset (HP:0003587)1.61306981
169Termporal pattern (HP:0011008)1.61306981
170Right ventricular cardiomyopathy (HP:0011663)1.61040734
171Hypoparathyroidism (HP:0000829)1.61030144
172Hypertensive crisis (HP:0100735)1.60257420
173Subacute progressive viral hepatitis (HP:0006572)1.59319110
174Growth hormone excess (HP:0000845)1.58580296
175Viral hepatitis (HP:0006562)1.58353291
176Patellar dislocation (HP:0002999)1.56187933
177Abnormality of nail color (HP:0100643)1.55311075
178Abnormal hair laboratory examination (HP:0003328)1.54777578
179Abnormal ossification of hand bones (HP:0005921)1.53967026
180Segmental peripheral demyelination/remyelination (HP:0003481)1.53366535
181Progressive hearing impairment (HP:0001730)1.50910411
182Abnormality of carpal bone ossification (HP:0006257)1.50743581
183Abnormality of the gastric mucosa (HP:0004295)1.50641242
184Deviation of the thumb (HP:0009603)1.50203923
185Short nail (HP:0001799)1.50132476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.02178155
2SMG13.91595349
3MAP3K103.49828104
4MAP4K13.44385830
5TRIB33.10517062
6PKN22.98772671
7ERN12.67527481
8PRPF4B2.67321278
9IRAK32.45006256
10ICK2.35421338
11STK102.20606870
12NEK22.05579793
13EPHA21.98192346
14FLT31.96789692
15GRK61.92240729
16TYK21.87793092
17LRRK21.77390371
18ZAP701.71855289
19BTK1.68808844
20JAK31.63285826
21RPS6KB21.58150990
22FGFR41.55982701
23PTK61.55618629
24NME21.54157605
25CDK41.53062989
26MAP2K31.50609281
27CSF1R1.48193622
28CDC71.46818858
29SIK11.46408084
30KIT1.37679069
31TBK11.34430975
32RPS6KA41.32917996
33CDK121.32507008
34TGFBR21.30024004
35RIPK41.23063523
36TGFBR11.20195809
37PIM11.16905015
38NLK1.16434793
39WEE11.16367163
40CDK61.15047417
41MAPKAPK31.10508614
42TAOK31.09270859
43TAOK21.09241147
44STK41.09159355
45BCKDK1.05149712
46KSR21.04649037
47MAPK111.00134442
48TESK10.98548859
49STK30.98319859
50MAP3K80.97573868
51BUB10.96790200
52SYK0.96563384
53CLK10.96369294
54BLK0.96064151
55PASK0.94563695
56IKBKE0.94070505
57PDPK10.93281688
58MAP3K30.92477768
59RIPK10.92349799
60DYRK30.92223194
61MAP3K130.91042658
62ITK0.90530023
63MST1R0.89738603
64PDGFRA0.86328496
65KDR0.84910164
66CSK0.82731136
67TEC0.82618041
68MAP3K10.82435946
69SCYL20.82204245
70BRSK20.77845591
71SIK30.77005981
72TAOK10.76123156
73EPHB10.75970617
74IRAK20.75045490
75JAK10.74966921
76TXK0.74362920
77NEK90.73322853
78ILK0.73009075
79RET0.72743735
80FGFR30.71359304
81JAK20.71121677
82AURKB0.70853846
83LCK0.70273544
84EIF2AK30.69578859
85RPS6KA20.69118237
86CDK70.68005742
87IKBKB0.67646742
88CHUK0.67622174
89HCK0.67448837
90EIF2AK10.66870103
91NEK60.66550046
92VRK20.66171242
93TTK0.65632120
94CDK90.65140920
95ATR0.64804146
96PAK40.61936572
97ARAF0.61659136
98MAP3K60.61494096
99MST40.58157612
100MUSK0.58132092
101HIPK20.57607596
102MAP3K140.55813459
103PDK10.54856510
104IRAK40.54619710
105MAP2K20.53975487
106PRKD20.53685316
107MAP3K20.51602360
108ACVR1B0.50697836
109PRKD30.50354436
110MAP3K70.49160729
111LYN0.49032577
112MARK30.48936917
113TESK20.48724498
114TTN0.48712662
115MAP3K110.48555728
116CDC42BPA0.47983882
117MAPK40.47955039
118BRAF0.47224117
119MTOR0.45412683
120PIM20.45040498
121ALK0.43981532
122PLK40.43895616
123SIK20.43715053
124RPS6KA60.42684093
125MARK20.41731573
126TNK20.41442876
127MAPKAPK20.40815798
128LATS20.40194574
129RPS6KB10.40126853
130PRKCI0.39222002
131DYRK1B0.39047022
132PLK10.38800269
133MELK0.38431195
134AURKA0.38366539
135RPS6KL10.38360424
136RPS6KC10.38360424
137BMX0.37873711
138PBK0.35842238
139CHEK20.35479348
140PTK20.35281445
141CDK80.34710845
142AKT20.34215382
143MAP2K10.33398225
144RPS6KA10.31253117
145PIK3CA0.31243592

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.88610504
2DNA replication_Homo sapiens_hsa030302.79322399
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.13999220
4Ribosome_Homo sapiens_hsa030101.94576416
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94178190
6Central carbon metabolism in cancer_Homo sapiens_hsa052301.88488896
7Mismatch repair_Homo sapiens_hsa034301.88301171
8Antigen processing and presentation_Homo sapiens_hsa046121.86337576
9Bladder cancer_Homo sapiens_hsa052191.81543062
10Fructose and mannose metabolism_Homo sapiens_hsa000511.78244404
11One carbon pool by folate_Homo sapiens_hsa006701.78115233
12Base excision repair_Homo sapiens_hsa034101.77852525
13Endometrial cancer_Homo sapiens_hsa052131.74038780
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.73129868
15B cell receptor signaling pathway_Homo sapiens_hsa046621.61411757
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.58532681
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.57101224
18VEGF signaling pathway_Homo sapiens_hsa043701.55745207
19Caffeine metabolism_Homo sapiens_hsa002321.43527098
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.42624154
21Non-homologous end-joining_Homo sapiens_hsa034501.41953704
22Selenocompound metabolism_Homo sapiens_hsa004501.41309912
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39374240
24Spliceosome_Homo sapiens_hsa030401.35902829
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35881202
26mTOR signaling pathway_Homo sapiens_hsa041501.35301126
27Pentose phosphate pathway_Homo sapiens_hsa000301.34778832
28Herpes simplex infection_Homo sapiens_hsa051681.32565499
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.30555569
30Sulfur relay system_Homo sapiens_hsa041221.30547616
31Leishmaniasis_Homo sapiens_hsa051401.26099230
32Cell cycle_Homo sapiens_hsa041101.25355360
33Acute myeloid leukemia_Homo sapiens_hsa052211.24955823
34Staphylococcus aureus infection_Homo sapiens_hsa051501.24681512
35Renal cell carcinoma_Homo sapiens_hsa052111.21699244
36Galactose metabolism_Homo sapiens_hsa000521.20061640
37Measles_Homo sapiens_hsa051621.18490717
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17792339
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17577373
40Homologous recombination_Homo sapiens_hsa034401.17368362
41Chronic myeloid leukemia_Homo sapiens_hsa052201.16224367
42Insulin signaling pathway_Homo sapiens_hsa049101.15407702
43Fatty acid degradation_Homo sapiens_hsa000711.14638684
44Prostate cancer_Homo sapiens_hsa052151.14208661
45Nucleotide excision repair_Homo sapiens_hsa034201.12054225
46Glioma_Homo sapiens_hsa052141.11232752
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09231599
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09221673
49RNA transport_Homo sapiens_hsa030131.09153815
50Hematopoietic cell lineage_Homo sapiens_hsa046401.05520358
51Complement and coagulation cascades_Homo sapiens_hsa046101.05140296
52ErbB signaling pathway_Homo sapiens_hsa040121.04269678
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.03992662
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03929281
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03265490
56Tryptophan metabolism_Homo sapiens_hsa003801.02508133
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02302520
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01699670
59Lysine degradation_Homo sapiens_hsa003101.01404015
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00862781
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00674134
62Osteoclast differentiation_Homo sapiens_hsa043800.97910714
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97422548
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96976225
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.94935537
66Folate biosynthesis_Homo sapiens_hsa007900.94528599
67Colorectal cancer_Homo sapiens_hsa052100.93127473
68AMPK signaling pathway_Homo sapiens_hsa041520.93075537
69Viral carcinogenesis_Homo sapiens_hsa052030.92941613
70Prion diseases_Homo sapiens_hsa050200.92419994
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92290566
72T cell receptor signaling pathway_Homo sapiens_hsa046600.89779223
73Toxoplasmosis_Homo sapiens_hsa051450.89294737
74Histidine metabolism_Homo sapiens_hsa003400.88894117
75Pyrimidine metabolism_Homo sapiens_hsa002400.87642950
76Small cell lung cancer_Homo sapiens_hsa052220.87310919
77Apoptosis_Homo sapiens_hsa042100.86728965
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.86063427
79Legionellosis_Homo sapiens_hsa051340.85369352
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85061650
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84497504
82Systemic lupus erythematosus_Homo sapiens_hsa053220.83766352
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83546038
84Lysosome_Homo sapiens_hsa041420.83265711
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83262107
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.82978327
87Hepatitis B_Homo sapiens_hsa051610.82747204
88Choline metabolism in cancer_Homo sapiens_hsa052310.82382729
89N-Glycan biosynthesis_Homo sapiens_hsa005100.81760926
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81334346
91HIF-1 signaling pathway_Homo sapiens_hsa040660.81314505
92Inositol phosphate metabolism_Homo sapiens_hsa005620.81252216
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.80968629
94p53 signaling pathway_Homo sapiens_hsa041150.80548151
95HTLV-I infection_Homo sapiens_hsa051660.80326220
96Proteoglycans in cancer_Homo sapiens_hsa052050.79715390
97Influenza A_Homo sapiens_hsa051640.79171471
98ABC transporters_Homo sapiens_hsa020100.78465024
99Thyroid cancer_Homo sapiens_hsa052160.77884424
100Arginine biosynthesis_Homo sapiens_hsa002200.77798052
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77181038
102Nitrogen metabolism_Homo sapiens_hsa009100.76646444
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75922926
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.75419718
105MicroRNAs in cancer_Homo sapiens_hsa052060.75151039
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74262756
107Epstein-Barr virus infection_Homo sapiens_hsa051690.73009632
108Biosynthesis of amino acids_Homo sapiens_hsa012300.70891530
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69694940
110Fanconi anemia pathway_Homo sapiens_hsa034600.68994743
111Estrogen signaling pathway_Homo sapiens_hsa049150.68281056
112Shigellosis_Homo sapiens_hsa051310.68135517
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67343455
114mRNA surveillance pathway_Homo sapiens_hsa030150.66917769
115beta-Alanine metabolism_Homo sapiens_hsa004100.66033368
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65302739
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65161821
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64902511
119Notch signaling pathway_Homo sapiens_hsa043300.64887389
120PPAR signaling pathway_Homo sapiens_hsa033200.64804029
121Pancreatic cancer_Homo sapiens_hsa052120.64256057
122Vibrio cholerae infection_Homo sapiens_hsa051100.64174458
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.63428365
124Non-small cell lung cancer_Homo sapiens_hsa052230.62861418
125Hepatitis C_Homo sapiens_hsa051600.62601891
126Insulin resistance_Homo sapiens_hsa049310.62365448
127Endocytosis_Homo sapiens_hsa041440.61703709
128Phenylalanine metabolism_Homo sapiens_hsa003600.61663884
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61485430
130RNA degradation_Homo sapiens_hsa030180.61064345
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60946964
132Chemical carcinogenesis_Homo sapiens_hsa052040.60277971
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57984734
134Tuberculosis_Homo sapiens_hsa051520.57825424
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56890887
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53884444
137Other glycan degradation_Homo sapiens_hsa005110.53350035
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.51801657
139Peroxisome_Homo sapiens_hsa041460.51779350
140Fat digestion and absorption_Homo sapiens_hsa049750.51715163
141Pertussis_Homo sapiens_hsa051330.51084340
142Platelet activation_Homo sapiens_hsa046110.50126441
143TNF signaling pathway_Homo sapiens_hsa046680.50125053
144Amoebiasis_Homo sapiens_hsa051460.49543020
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49515084
146Carbon metabolism_Homo sapiens_hsa012000.49053292
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46415638
148Prolactin signaling pathway_Homo sapiens_hsa049170.46403027
149Vitamin B6 metabolism_Homo sapiens_hsa007500.44185935
150GnRH signaling pathway_Homo sapiens_hsa049120.43682902

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