SMARCE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.71768353
2establishment of integrated proviral latency (GO:0075713)4.17048478
3DNA unwinding involved in DNA replication (GO:0006268)4.08751290
4DNA ligation (GO:0006266)4.08020260
5pyrimidine nucleobase catabolic process (GO:0006208)4.04402872
6DNA damage response, detection of DNA damage (GO:0042769)3.89515654
7DNA double-strand break processing (GO:0000729)3.83566972
8cullin deneddylation (GO:0010388)3.71311923
9protein localization to kinetochore (GO:0034501)3.65121653
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.55886552
11kinetochore organization (GO:0051383)3.53513089
12DNA topological change (GO:0006265)3.39723856
13dosage compensation (GO:0007549)3.39206296
14negative regulation of RNA splicing (GO:0033119)3.38366516
15protein deneddylation (GO:0000338)3.32599868
16regulation of helicase activity (GO:0051095)3.30056911
17neural tube formation (GO:0001841)3.29965281
18DNA strand elongation involved in DNA replication (GO:0006271)3.29370361
19establishment of viral latency (GO:0019043)3.25256986
20mitotic metaphase plate congression (GO:0007080)3.21359133
21limb bud formation (GO:0060174)3.21019211
22intraciliary transport (GO:0042073)3.19410502
23mitotic chromosome condensation (GO:0007076)3.19148083
24DNA strand elongation (GO:0022616)3.19049654
25ribosomal small subunit assembly (GO:0000028)3.16353703
26nuclear pore organization (GO:0006999)3.11183435
27protein localization to chromosome, centromeric region (GO:0071459)3.10950236
28nucleobase catabolic process (GO:0046113)3.10344882
29sequestering of actin monomers (GO:0042989)3.08965621
30nuclear pore complex assembly (GO:0051292)3.05367965
31mitotic recombination (GO:0006312)3.05256227
32non-recombinational repair (GO:0000726)3.04800014
33double-strand break repair via nonhomologous end joining (GO:0006303)3.04800014
34kinetochore assembly (GO:0051382)3.03700131
35mitotic nuclear envelope disassembly (GO:0007077)3.02417782
36mitotic sister chromatid cohesion (GO:0007064)2.98837256
37telomere maintenance via semi-conservative replication (GO:0032201)2.97968375
38sister chromatid segregation (GO:0000819)2.96601245
39resolution of meiotic recombination intermediates (GO:0000712)2.95598325
40metaphase plate congression (GO:0051310)2.94925909
41DNA integration (GO:0015074)2.94231386
42mRNA splicing, via spliceosome (GO:0000398)2.94206057
43RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94206057
44RNA splicing, via transesterification reactions (GO:0000375)2.92171837
45negative regulation of mRNA processing (GO:0050686)2.91374072
46microtubule depolymerization (GO:0007019)2.90712783
47DNA replication-independent nucleosome organization (GO:0034724)2.88488119
48DNA replication-independent nucleosome assembly (GO:0006336)2.88488119
49telomere maintenance via recombination (GO:0000722)2.88268684
50viral mRNA export from host cell nucleus (GO:0046784)2.87771399
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87397378
52DNA replication checkpoint (GO:0000076)2.86957960
53DNA replication initiation (GO:0006270)2.86035581
54regulation of development, heterochronic (GO:0040034)2.84681203
55establishment of chromosome localization (GO:0051303)2.83763129
56spindle assembly checkpoint (GO:0071173)2.82283441
57regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.82002037
58retinal ganglion cell axon guidance (GO:0031290)2.81534729
59organelle disassembly (GO:1903008)2.80616401
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80446268
61proteasome assembly (GO:0043248)2.80402382
62CENP-A containing nucleosome assembly (GO:0034080)2.79797065
63mitotic spindle assembly checkpoint (GO:0007094)2.79399030
64nonmotile primary cilium assembly (GO:0035058)2.79063628
65spindle checkpoint (GO:0031577)2.78848939
66nuclear envelope disassembly (GO:0051081)2.78645797
67membrane disassembly (GO:0030397)2.78645797
68regulation of mRNA splicing, via spliceosome (GO:0048024)2.78044151
69negative regulation of mitotic sister chromatid separation (GO:2000816)2.77016258
70negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77016258
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77016258
72negative regulation of sister chromatid segregation (GO:0033046)2.77016258
73formation of translation preinitiation complex (GO:0001731)2.75340685
74somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75268620
75somatic hypermutation of immunoglobulin genes (GO:0016446)2.75268620
76negative regulation of chromosome segregation (GO:0051985)2.74803731
77termination of RNA polymerase II transcription (GO:0006369)2.73859758
78paraxial mesoderm development (GO:0048339)2.73331205
79regulation of mitotic metaphase/anaphase transition (GO:0030071)2.72397263
80mitotic spindle checkpoint (GO:0071174)2.72159581
81spermatid nucleus differentiation (GO:0007289)2.71856011
82* ATP-dependent chromatin remodeling (GO:0043044)2.71853423
83positive regulation of mitochondrial fission (GO:0090141)2.71465330
84protein localization to chromosome (GO:0034502)2.70574789
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69467236
86attachment of spindle microtubules to kinetochore (GO:0008608)2.68630769
87olfactory bulb development (GO:0021772)2.68565122
88negative regulation of DNA recombination (GO:0045910)2.68409504
89replication fork processing (GO:0031297)2.68327727
90DNA replication-dependent nucleosome organization (GO:0034723)2.67842421
91DNA replication-dependent nucleosome assembly (GO:0006335)2.67842421
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.67000564
93histone H2A acetylation (GO:0043968)2.65885660
94chromatin remodeling at centromere (GO:0031055)2.65745532
95DNA catabolic process, exonucleolytic (GO:0000738)2.65724205
96regulation of sister chromatid cohesion (GO:0007063)2.65553077
97ribonucleoprotein complex disassembly (GO:0032988)2.65526229
98DNA duplex unwinding (GO:0032508)2.65189448
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64762840
100DNA geometric change (GO:0032392)2.64355699
1013-UTR-mediated mRNA stabilization (GO:0070935)2.60688985
102somite development (GO:0061053)2.60465618
103mitotic sister chromatid segregation (GO:0000070)2.60130622
104protein K11-linked ubiquitination (GO:0070979)2.60129403
105spliceosomal snRNP assembly (GO:0000387)2.59604306
106regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57353590
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56894120
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56894120
109regulation of chromosome segregation (GO:0051983)2.56721840
110RNA export from nucleus (GO:0006405)2.56427167
111regulation of sister chromatid segregation (GO:0033045)2.55226535
112regulation of mitotic sister chromatid separation (GO:0010965)2.55226535
113regulation of mitotic sister chromatid segregation (GO:0033047)2.55226535
114histone exchange (GO:0043486)2.55159799
115alternative mRNA splicing, via spliceosome (GO:0000380)2.54990210
116spliceosomal complex assembly (GO:0000245)2.54952178
117maturation of SSU-rRNA (GO:0030490)2.54755714
118regulation of spindle organization (GO:0090224)2.54013261
119nucleotide-excision repair, DNA gap filling (GO:0006297)2.53086637
120establishment of protein localization to mitochondrial membrane (GO:0090151)2.53047199
121cilium morphogenesis (GO:0060271)2.52561164
122spliceosomal tri-snRNP complex assembly (GO:0000244)2.52383134
123mRNA export from nucleus (GO:0006406)2.50791662
124* nucleosome disassembly (GO:0006337)2.49547231
125* protein-DNA complex disassembly (GO:0032986)2.49547231
126telomere maintenance via telomere lengthening (GO:0010833)2.49291459
127mismatch repair (GO:0006298)2.48742959
128regulation of mitotic spindle checkpoint (GO:1903504)2.47949680
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47949680
130meiotic chromosome segregation (GO:0045132)2.47840448
131mRNA splice site selection (GO:0006376)2.47837243
132presynaptic membrane assembly (GO:0097105)2.47788859
133positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.47198894
134positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.47198894
135positive regulation of mitotic sister chromatid separation (GO:1901970)2.47198894
136chromatin assembly or disassembly (GO:0006333)2.47120036
137nucleobase biosynthetic process (GO:0046112)2.45488459
138regulation of centrosome cycle (GO:0046605)2.43745290
139regulation of DNA endoreduplication (GO:0032875)2.42973973
140translesion synthesis (GO:0019985)2.41731234
141postreplication repair (GO:0006301)2.41405705
142regulation of centriole replication (GO:0046599)2.41342522
143mRNA transport (GO:0051028)2.40051779
144negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.39791573
145RNA stabilization (GO:0043489)2.39423295
146mRNA stabilization (GO:0048255)2.39423295
147chromosome segregation (GO:0007059)2.39116681
148pre-miRNA processing (GO:0031054)2.38607038
149regulation of telomere maintenance (GO:0032204)2.37896641
150RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.37093463
151positive regulation of chromosome segregation (GO:0051984)2.36451064
152centriole replication (GO:0007099)2.36376247
153DNA conformation change (GO:0071103)2.36139498
154negative regulation of mRNA metabolic process (GO:1903312)2.36061979
155negative regulation of DNA-dependent DNA replication (GO:2000104)2.35735995
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.35444363
157negative regulation of telomere maintenance (GO:0032205)2.32343961
158mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.31374644
159sympathetic nervous system development (GO:0048485)2.30967691
160water-soluble vitamin biosynthetic process (GO:0042364)2.30879874
161cornea development in camera-type eye (GO:0061303)2.30609621
162positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.28921037
163respiratory chain complex IV assembly (GO:0008535)2.28099704
164regulation of timing of cell differentiation (GO:0048505)2.27098453
165forebrain neuron differentiation (GO:0021879)2.27033931
166protein neddylation (GO:0045116)2.26806874
167V(D)J recombination (GO:0033151)2.26357452
168epithelial cilium movement (GO:0003351)2.25351089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.20679579
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.07415655
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.08562346
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.61896161
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.59586005
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.30896151
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20926075
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.01323550
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85509779
10ZNF274_21170338_ChIP-Seq_K562_Hela2.78165075
11IGF1R_20145208_ChIP-Seq_DFB_Human2.73461344
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53411330
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52263195
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48997965
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47304278
16EWS_26573619_Chip-Seq_HEK293_Human2.45113872
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.36219445
18XRN2_22483619_ChIP-Seq_HELA_Human2.35728752
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34663848
20* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31748938
21FUS_26573619_Chip-Seq_HEK293_Human2.31393045
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30581706
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.27712945
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27238593
25MYC_22102868_ChIP-Seq_BL_Human2.27016454
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19609927
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18287553
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.16267457
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15301632
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12291587
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07926159
32AR_21909140_ChIP-Seq_LNCAP_Human2.05971720
33CIITA_25753668_ChIP-Seq_RAJI_Human2.04400196
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01433973
35TAF15_26573619_Chip-Seq_HEK293_Human2.00783015
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96055796
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.94847861
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94737967
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92682065
40VDR_23849224_ChIP-Seq_CD4+_Human1.86124609
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85703506
42ELK1_19687146_ChIP-ChIP_HELA_Human1.83012299
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82307306
44* TTF2_22483619_ChIP-Seq_HELA_Human1.80596325
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78862369
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.77232516
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76299840
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75970172
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73639545
50FOXP3_21729870_ChIP-Seq_TREG_Human1.64505441
51IRF1_19129219_ChIP-ChIP_H3396_Human1.63658122
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63418205
53GABP_19822575_ChIP-Seq_HepG2_Human1.61445463
54VDR_22108803_ChIP-Seq_LS180_Human1.57976057
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57150282
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57065534
57* DCP1A_22483619_ChIP-Seq_HELA_Human1.53983749
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52815009
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52624424
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52516361
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51531871
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51128371
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50949573
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50379259
65P300_19829295_ChIP-Seq_ESCs_Human1.48482216
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46054323
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44369136
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44191495
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43279705
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43222229
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43188754
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41492736
73RNF2_27304074_Chip-Seq_NSC_Mouse1.40950549
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.39222634
75GBX2_23144817_ChIP-Seq_PC3_Human1.39098987
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38383631
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.37062418
78KDM5A_27292631_Chip-Seq_BREAST_Human1.35594280
79VDR_21846776_ChIP-Seq_THP-1_Human1.35124382
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29252862
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23802109
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.23647048
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21693358
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21569764
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21274015
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19372221
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.19256778
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18297274
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17224094
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16733627
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16618750
92* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15146564
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13911485
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13776966
95CBP_20019798_ChIP-Seq_JUKART_Human1.13477018
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13477018
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12120092
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11339127
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10981649
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10111739
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.10030160
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10007466
103* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08243833
104TFEB_21752829_ChIP-Seq_HELA_Human1.03091915
105* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02496441
106FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02439325
107* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01757468
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01741627
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01172433
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.01040467
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00656876
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00596765
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00051793
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99580896
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98964244
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.97140709
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96886571
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96611661
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96518968
120KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96134733
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95602188
122KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95590674
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95099864
124GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94857006
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.94150830
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.93656052
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93141400
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92640762
129SPI1_23547873_ChIP-Seq_NB4_Human0.92115765
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91546039
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91064899
132MYC_18940864_ChIP-ChIP_HL60_Human0.90704667
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89952435
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89510960
135* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89278761
136* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88604957
137CHD1_26751641_Chip-Seq_LNCaP_Human0.88344391
138UTX_26944678_Chip-Seq_JUKART_Human0.88044055
139MAF_26560356_Chip-Seq_TH1_Human0.87650794
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.86735605
141SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86504197
142GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83474144
143* TCF7_22412390_ChIP-Seq_EML_Mouse0.82908564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.07629162
2MP0010030_abnormal_orbit_morphology2.97011411
3MP0010094_abnormal_chromosome_stability2.76990571
4MP0003123_paternal_imprinting2.75898272
5MP0003111_abnormal_nucleus_morphology2.70364231
6MP0003121_genomic_imprinting2.68547867
7MP0001529_abnormal_vocalization2.67260697
8MP0003077_abnormal_cell_cycle2.66731534
9MP0009053_abnormal_anal_canal2.60712116
10MP0004957_abnormal_blastocyst_morpholog2.47927578
11MP0000537_abnormal_urethra_morphology2.47660164
12MP0005499_abnormal_olfactory_system2.33921093
13MP0005394_taste/olfaction_phenotype2.33921093
14MP0008007_abnormal_cellular_replicative2.32809792
15MP0008057_abnormal_DNA_replication2.31038250
16MP0003122_maternal_imprinting2.28951937
17MP0006072_abnormal_retinal_apoptosis2.16959810
18MP0008058_abnormal_DNA_repair2.10217165
19MP0002234_abnormal_pharynx_morphology1.96092755
20MP0003315_abnormal_perineum_morphology1.84554095
21MP0008932_abnormal_embryonic_tissue1.81507952
22MP0004133_heterotaxia1.78918085
23MP0001984_abnormal_olfaction1.76371098
24MP0003385_abnormal_body_wall1.75536595
25MP0000778_abnormal_nervous_system1.74024827
26MP0003880_abnormal_central_pattern1.72410069
27MP0002938_white_spotting1.65177093
28MP0000350_abnormal_cell_proliferation1.64934075
29MP0005076_abnormal_cell_differentiation1.64911323
30MP0006054_spinal_hemorrhage1.63047341
31MP0003567_abnormal_fetal_cardiomyocyte1.62741480
32MP0001730_embryonic_growth_arrest1.62570441
33MP0002396_abnormal_hematopoietic_system1.61788574
34MP0006276_abnormal_autonomic_nervous1.60458773
35MP0003890_abnormal_embryonic-extraembry1.56752264
36MP0005084_abnormal_gallbladder_morpholo1.56354562
37MP0003787_abnormal_imprinting1.54330577
38MP0003942_abnormal_urinary_system1.52821257
39MP0010352_gastrointestinal_tract_polyps1.52753209
40MP0008995_early_reproductive_senescence1.50734873
41MP0001672_abnormal_embryogenesis/_devel1.49474458
42MP0005380_embryogenesis_phenotype1.49474458
43MP0004197_abnormal_fetal_growth/weight/1.47584703
44MP0000631_abnormal_neuroendocrine_gland1.45087900
45MP0000049_abnormal_middle_ear1.44690511
46MP0001293_anophthalmia1.43261747
47MP0002088_abnormal_embryonic_growth/wei1.42232786
48MP0004808_abnormal_hematopoietic_stem1.42196897
49MP0003984_embryonic_growth_retardation1.42172902
50MP0001697_abnormal_embryo_size1.41844773
51MP0005253_abnormal_eye_physiology1.41059022
52MP0002085_abnormal_embryonic_tissue1.40065051
53MP0003119_abnormal_digestive_system1.39355852
54MP0004147_increased_porphyrin_level1.38900706
55MP0003937_abnormal_limbs/digits/tail_de1.37986766
56MP0002282_abnormal_trachea_morphology1.37070317
57MP0003705_abnormal_hypodermis_morpholog1.35776514
58MP0002084_abnormal_developmental_patter1.34815645
59MP0000372_irregular_coat_pigmentation1.33992021
60MP0003136_yellow_coat_color1.33869478
61MP0000566_synostosis1.32115315
62MP0008789_abnormal_olfactory_epithelium1.29498390
63MP0003115_abnormal_respiratory_system1.25960668
64MP0003718_maternal_effect1.25722539
65MP0008877_abnormal_DNA_methylation1.23543501
66MP0002932_abnormal_joint_morphology1.21640836
67MP0005503_abnormal_tendon_morphology1.21013149
68MP0009250_abnormal_appendicular_skeleto1.20984094
69MP0000569_abnormal_digit_pigmentation1.20905075
70MP0000647_abnormal_sebaceous_gland1.19135282
71MP0001299_abnormal_eye_distance/1.18615120
72MP0003283_abnormal_digestive_organ1.18215346
73MP0002822_catalepsy1.17372595
74MP0002086_abnormal_extraembryonic_tissu1.17274445
75MP0000490_abnormal_crypts_of1.16713409
76MP0000428_abnormal_craniofacial_morphol1.16560762
77MP0005367_renal/urinary_system_phenotyp1.14274461
78MP0000516_abnormal_urinary_system1.14274461
79MP0002080_prenatal_lethality1.14003279
80MP0003935_abnormal_craniofacial_develop1.12987864
81MP0002249_abnormal_larynx_morphology1.12471645
82MP0001188_hyperpigmentation1.11416622
83MP0000733_abnormal_muscle_development1.10898518
84MP0001286_abnormal_eye_development1.09982980
85MP0005391_vision/eye_phenotype1.09948545
86MP0003941_abnormal_skin_development1.06952004
87MP0005645_abnormal_hypothalamus_physiol1.05791966
88MP0003221_abnormal_cardiomyocyte_apopto1.04918725
89MP0003755_abnormal_palate_morphology1.04094936
90MP0009697_abnormal_copulation1.00611662
91MP0005248_abnormal_Harderian_gland0.98316533
92MP0003786_premature_aging0.97841422
93MP0002116_abnormal_craniofacial_bone0.97578366
94MP0002184_abnormal_innervation0.97526045
95MP0002653_abnormal_ependyma_morphology0.96570777
96MP0000313_abnormal_cell_death0.96312562
97MP0000534_abnormal_ureter_morphology0.95912079
98MP0002111_abnormal_tail_morphology0.94950286
99MP0002163_abnormal_gland_morphology0.94371811
100MP0000703_abnormal_thymus_morphology0.93476638
101MP0002736_abnormal_nociception_after0.93415933
102MP0010307_abnormal_tumor_latency0.92640358
103MP0009672_abnormal_birth_weight0.92068271
104MP0002092_abnormal_eye_morphology0.91489312
105MP0000432_abnormal_head_morphology0.90183766
106MP0001915_intracranial_hemorrhage0.89634781
107MP0009703_decreased_birth_body0.89074468
108MP0002233_abnormal_nose_morphology0.88791685
109MP0001849_ear_inflammation0.87775829
110MP0009278_abnormal_bone_marrow0.87673897
111MP0002210_abnormal_sex_determination0.87398330
112MP0006292_abnormal_olfactory_placode0.87341263
113MP0002109_abnormal_limb_morphology0.87006334
114MP0002697_abnormal_eye_size0.86739829
115MP0002925_abnormal_cardiovascular_devel0.86074893
116MP0009333_abnormal_splenocyte_physiolog0.84380211
117MP0006035_abnormal_mitochondrial_morpho0.83811280
118MP0002752_abnormal_somatic_nervous0.83304934
119MP0003943_abnormal_hepatobiliary_system0.82172349
120MP0002019_abnormal_tumor_incidence0.81364130
121MP0002114_abnormal_axial_skeleton0.81309713
122MP0002751_abnormal_autonomic_nervous0.81281233
123MP0003763_abnormal_thymus_physiology0.81112607
124MP0002398_abnormal_bone_marrow0.79706739
125MP0002102_abnormal_ear_morphology0.79655501
126MP0008438_abnormal_cutaneous_collagen0.78447687
127MP0002160_abnormal_reproductive_system0.78174410
128MP0001270_distended_abdomen0.76824316
129MP0001929_abnormal_gametogenesis0.76668852
130MP0004811_abnormal_neuron_physiology0.76581199
131MP0002557_abnormal_social/conspecific_i0.76175631
132MP0001879_abnormal_lymphatic_vessel0.75974508
133MP0005508_abnormal_skeleton_morphology0.75966918
134MP0002081_perinatal_lethality0.75583063
135MP0002928_abnormal_bile_duct0.75161593
136MP0005187_abnormal_penis_morphology0.75018458
137MP0003861_abnormal_nervous_system0.74856903
138MP0003938_abnormal_ear_development0.74804248
139MP0000767_abnormal_smooth_muscle0.74095761
140MP0000955_abnormal_spinal_cord0.74067976
141MP0002837_dystrophic_cardiac_calcinosis0.72989794
142MP0002177_abnormal_outer_ear0.72555695
143MP0000653_abnormal_sex_gland0.72437747
144MP0001145_abnormal_male_reproductive0.72078297

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.77302458
2Short 4th metacarpal (HP:0010044)3.77302458
3True hermaphroditism (HP:0010459)3.28982890
4Abnormality of the labia minora (HP:0012880)3.17577612
5Renal duplication (HP:0000075)3.08642084
6Cortical dysplasia (HP:0002539)3.08051126
7Medial flaring of the eyebrow (HP:0010747)3.05162846
8Pancreatic cysts (HP:0001737)3.04683351
9Pancreatic fibrosis (HP:0100732)3.00505960
10Congenital primary aphakia (HP:0007707)2.91192092
11Spinal cord lesions (HP:0100561)2.90242596
12Syringomyelia (HP:0003396)2.90242596
13Colon cancer (HP:0003003)2.87316712
14Abnormality of the 4th metacarpal (HP:0010012)2.85858641
15Gait imbalance (HP:0002141)2.79004488
16Nephrogenic diabetes insipidus (HP:0009806)2.75056651
17Molar tooth sign on MRI (HP:0002419)2.67594073
18Abnormality of midbrain morphology (HP:0002418)2.67594073
19* Patellar aplasia (HP:0006443)2.65360283
20* Aplasia/Hypoplasia of the patella (HP:0006498)2.59969524
21Genital tract atresia (HP:0001827)2.59638159
22Nephronophthisis (HP:0000090)2.59455991
23Vaginal atresia (HP:0000148)2.56096744
24Retinal dysplasia (HP:0007973)2.55984845
25Selective tooth agenesis (HP:0001592)2.51455932
26Increased nuchal translucency (HP:0010880)2.48669780
27Short middle phalanx of the 5th finger (HP:0004220)2.48230928
28Volvulus (HP:0002580)2.47251812
29Hepatoblastoma (HP:0002884)2.45980260
30Abnormal number of incisors (HP:0011064)2.45543202
31Ectopic kidney (HP:0000086)2.45318442
32Hyperglycinemia (HP:0002154)2.44634464
33Diastasis recti (HP:0001540)2.41139877
34Deviation of the thumb (HP:0009603)2.40558017
35Asymmetry of the thorax (HP:0001555)2.39533838
36Abnormal lung lobation (HP:0002101)2.35701354
37Medulloblastoma (HP:0002885)2.32144938
38Intestinal atresia (HP:0011100)2.31556393
39Short 5th finger (HP:0009237)2.28643403
40Proximal placement of thumb (HP:0009623)2.28035400
41Abnormality of the anterior horn cell (HP:0006802)2.27728250
42Degeneration of anterior horn cells (HP:0002398)2.27728250
43Nephroblastoma (Wilms tumor) (HP:0002667)2.24569119
44Methylmalonic acidemia (HP:0002912)2.22732555
45Atresia of the external auditory canal (HP:0000413)2.20931674
46Aplasia/Hypoplasia of the sternum (HP:0006714)2.20663134
47Lissencephaly (HP:0001339)2.18869532
48Embryonal renal neoplasm (HP:0011794)2.17499562
49Abnormality of the renal medulla (HP:0100957)2.15887449
50Acute necrotizing encephalopathy (HP:0006965)2.14850300
51Meckel diverticulum (HP:0002245)2.13858855
52Increased hepatocellular lipid droplets (HP:0006565)2.13414784
53Occipital encephalocele (HP:0002085)2.12733837
54Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.11682918
55Trigonocephaly (HP:0000243)2.10627519
56Optic nerve coloboma (HP:0000588)2.09927953
57* Abnormality of the intervertebral disk (HP:0005108)2.08782390
58Reticulocytopenia (HP:0001896)2.08701687
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.07338776
60Postaxial hand polydactyly (HP:0001162)2.07183013
61Chromsome breakage (HP:0040012)2.06491194
62Abnormality of the ileum (HP:0001549)2.05502754
63Abnormality of the fingertips (HP:0001211)2.04849875
64Broad foot (HP:0001769)2.04349386
65Preaxial hand polydactyly (HP:0001177)2.04043688
66Postaxial foot polydactyly (HP:0001830)2.03700530
67Deep philtrum (HP:0002002)2.00531403
68Glioma (HP:0009733)1.99564126
69Broad palm (HP:0001169)1.97939660
70Chronic hepatic failure (HP:0100626)1.96639026
71Long eyelashes (HP:0000527)1.95991880
72Lipid accumulation in hepatocytes (HP:0006561)1.95869779
73Acute encephalopathy (HP:0006846)1.95444243
74Poor coordination (HP:0002370)1.94660348
75Mesomelia (HP:0003027)1.94497188
76Sclerocornea (HP:0000647)1.94296059
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92753789
78Abnormality of the astrocytes (HP:0100707)1.91735769
79Astrocytoma (HP:0009592)1.91735769
80Decreased testicular size (HP:0008734)1.91414785
81Pelvic girdle muscle weakness (HP:0003749)1.90968469
82Mitochondrial inheritance (HP:0001427)1.90845250
83Broad thumb (HP:0011304)1.90803931
84Increased CSF lactate (HP:0002490)1.88344386
85Renal hypoplasia (HP:0000089)1.87725383
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.87245696
87Hyperacusis (HP:0010780)1.86906585
8811 pairs of ribs (HP:0000878)1.86066040
89Bifid tongue (HP:0010297)1.86016672
90Subacute progressive viral hepatitis (HP:0006572)1.85914178
91Anencephaly (HP:0002323)1.85342844
92Progressive macrocephaly (HP:0004481)1.84259205
93Bicuspid aortic valve (HP:0001647)1.83823621
94Hypoplastic pelvis (HP:0008839)1.83520762
95Micropenis (HP:0000054)1.82894982
96Hepatocellular necrosis (HP:0001404)1.82366223
97Abnormality of the calcaneus (HP:0008364)1.81080184
98Birth length less than 3rd percentile (HP:0003561)1.80988960
99Abnormality of the metopic suture (HP:0005556)1.80635360
100Abnormal mitochondria in muscle tissue (HP:0008316)1.80206482
101Cutaneous melanoma (HP:0012056)1.80003822
102Abnormality of the aortic arch (HP:0012303)1.77875098
103Hepatic necrosis (HP:0002605)1.76663849
104Sloping forehead (HP:0000340)1.76339434
105Optic nerve hypoplasia (HP:0000609)1.75327689
106Narrow forehead (HP:0000341)1.74583320
107Broad phalanges of the hand (HP:0009768)1.74503733
108Gonadotropin excess (HP:0000837)1.73139103
109Drooling (HP:0002307)1.72235410
110Anophthalmia (HP:0000528)1.71297130
111Triphalangeal thumb (HP:0001199)1.71244048
112Specific learning disability (HP:0001328)1.70714300
113Aplasia/hypoplasia of the uterus (HP:0008684)1.70639367
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.70313868
115Skull defect (HP:0001362)1.69396964
116Supernumerary spleens (HP:0009799)1.69254999
117Small intestinal stenosis (HP:0012848)1.69191924
118Duodenal stenosis (HP:0100867)1.69191924
119Scrotal hypoplasia (HP:0000046)1.68484086
120Cystic liver disease (HP:0006706)1.67629527
121Tubulointerstitial nephritis (HP:0001970)1.67548288
122Broad toe (HP:0001837)1.67196968
123Type II lissencephaly (HP:0007260)1.67184927
124Abnormality of chromosome stability (HP:0003220)1.67131560
125Long clavicles (HP:0000890)1.66496319
126Facial cleft (HP:0002006)1.65546850
127* Dandy-Walker malformation (HP:0001305)1.65421007
128Cerebellar dysplasia (HP:0007033)1.65249595
129Abnormal hair whorl (HP:0010721)1.64953723
130Abnormality of the radial head (HP:0003995)1.64369122
131Midline defect of the nose (HP:0004122)1.64088092
132Abnormality of the incisor (HP:0000676)1.63683937
133Wrist flexion contracture (HP:0001239)1.63556858
134Prominent metopic ridge (HP:0005487)1.62655604
135Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.62610580
136Long palpebral fissure (HP:0000637)1.62476747
137Gastrointestinal atresia (HP:0002589)1.62052614
138Broad finger (HP:0001500)1.61964375
139Renal cortical cysts (HP:0000803)1.60969452
140Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.60279612
141Short tibia (HP:0005736)1.60266417
142Dislocated radial head (HP:0003083)1.59440502
143Aganglionic megacolon (HP:0002251)1.59388898
144Oligodactyly (hands) (HP:0001180)1.59384125
145Septo-optic dysplasia (HP:0100842)1.59186006
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59111023
147Neoplasm of the adrenal cortex (HP:0100641)1.59052312
148Astigmatism (HP:0000483)1.59022353
149Male pseudohermaphroditism (HP:0000037)1.58803053
150Malignant gastrointestinal tract tumors (HP:0006749)1.58477767
151Gastrointestinal carcinoma (HP:0002672)1.58477767
152Preauricular skin tag (HP:0000384)1.57778014
153Broad alveolar ridges (HP:0000187)1.56944296
154Myelodysplasia (HP:0002863)1.56716929
155Ependymoma (HP:0002888)1.56291816
156High anterior hairline (HP:0009890)1.55807087
157Carpal synostosis (HP:0009702)1.55410535
158Carpal bone hypoplasia (HP:0001498)1.55034189
159Broad phalanx (HP:0006009)1.53786694
160Morphological abnormality of the middle ear (HP:0008609)1.53179644
161Neoplasm of the pancreas (HP:0002894)1.53059045
162Abnormality of the musculature of the pelvis (HP:0001469)1.53052676
163Abnormality of the hip-girdle musculature (HP:0001445)1.53052676
164Abnormal pancreas size (HP:0012094)1.52797233
165Skin tags (HP:0010609)1.51972666
166Increased density of long bones (HP:0006392)1.51934076
167* Cutis marmorata (HP:0000965)1.51386959
168Shoulder girdle muscle weakness (HP:0003547)1.50812046
169* Congenital diaphragmatic hernia (HP:0000776)1.50809374
170Abnormality of the phalanges of the hallux (HP:0010057)1.50708389
171Facial hemangioma (HP:0000329)1.50523817
172Abnormality of the parietal bone (HP:0002696)1.49884029
173Hypospadias (HP:0000047)1.48778414
174Shallow orbits (HP:0000586)1.48310343
175Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.48125876
176Shawl scrotum (HP:0000049)1.47874726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.55739146
2TRIM283.04552229
3BUB12.85506024
4MAP3K42.84294056
5SRPK12.81055790
6ERBB32.76474792
7MKNK12.59880993
8MAP3K102.59070335
9WNK32.54360798
10PLK42.42981772
11MAP4K22.29261672
12MAP2K72.22855927
13NEK22.19968372
14VRK22.11495991
15TGFBR12.08972207
16WEE11.98718060
17PASK1.97966603
18MARK11.92706455
19EPHB21.84636951
20BRSK21.84178258
21SIK31.83936900
22EIF2AK11.83734866
23MKNK21.78001212
24CASK1.70634157
25DYRK31.68442115
26RPS6KA41.67671796
27FRK1.67333625
28TAF11.65384774
29CDK121.64852924
30BMPR1B1.62141153
31ACVR1B1.60446763
32ATR1.58891197
33CDK191.57253303
34CSNK1G31.55776213
35ZAK1.51397725
36PLK31.50445165
37CSNK1G11.48308918
38PLK11.45205502
39BRSK11.45122440
40PKN21.43002586
41CSNK1A1L1.40737883
42AURKB1.40152308
43EEF2K1.38724189
44CSNK1G21.38077336
45TNIK1.37613798
46TLK11.35193118
47STK31.34064719
48LATS11.33185638
49TSSK61.30852146
50CDK71.28316443
51TTK1.27494032
52STK41.25881010
53PLK21.23708142
54PBK1.22463491
55RPS6KB21.21768400
56PAK41.20853950
57TRIB31.20155752
58PNCK1.20015129
59MAPK131.18891390
60NEK11.12091540
61CDK41.11968130
62NUAK11.11941535
63BCKDK1.10353560
64STK101.10310508
65VRK11.09953747
66CHEK11.06645949
67CHUK1.05485682
68CHEK21.05224745
69CCNB11.04942320
70NEK91.04549585
71MELK1.02527487
72CLK10.98470221
73FGFR20.97403474
74TESK10.96344404
75BRD40.95180465
76STK240.93218006
77ILK0.92295869
78CDK60.91885012
79STK38L0.90412675
80CDK80.89883741
81LRRK20.89856858
82PIM10.89125467
83STK160.88814778
84DYRK20.87917853
85BCR0.85797462
86MINK10.85609556
87TESK20.85579747
88MAP3K80.82319362
89ATM0.80586780
90KSR10.78554452
91CDK20.77656831
92PDGFRA0.77137431
93INSRR0.76841779
94MST40.75952667
95PTK60.75724738
96PAK30.75424822
97EPHA30.73808293
98AURKA0.70187547
99CDK30.69428486
100NME10.69012023
101FGFR10.64931251
102CDK10.63676981
103EIF2AK30.63598604
104MAP2K40.63115643
105DYRK1B0.62964119
106LIMK10.62053917
107BLK0.59869823
108YES10.58401223
109ADRBK20.56757322
110EIF2AK20.56061340
111IRAK40.56009848
112GRK10.55382650
113TTN0.55204455
114MAP4K10.54986009
115FLT30.54923489
116PAK20.53594397
117MTOR0.53367355
118PRKCE0.51853235
119PRKCG0.51676747
120UHMK10.50298066
121FER0.49795228
122CSNK2A10.48815331
123CDK140.46942315
124MUSK0.46586088
125RPS6KA10.46348104
126TAOK20.46284873
127BTK0.45809757
128CSNK1E0.45652065
129CDK180.45646215
130JAK30.45247044
131CDK90.45224450
132AKT10.43269269
133MARK30.43179687
134PIM20.42404881
135PINK10.41179224
136TIE10.41117472
137NME20.40823555
138NTRK20.40588899
139OXSR10.40411574
140OBSCN0.40349499
141CSNK1D0.40051104
142ERBB20.39890167
143DMPK0.39463078
144DDR20.39452978
145PAK10.39138304
146CDK11A0.38685242
147AKT20.38037223
148MAPKAPK20.38031058
149CSNK2A20.37928336
150FGFR30.37775478
151PRKDC0.37412259
152CDK150.35130761
153ERBB40.31770839

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.60964352
2Spliceosome_Homo sapiens_hsa030403.23833507
3Protein export_Homo sapiens_hsa030603.12991555
4Mismatch repair_Homo sapiens_hsa034303.04373607
5Base excision repair_Homo sapiens_hsa034102.78740413
6Cell cycle_Homo sapiens_hsa041102.77874489
7RNA transport_Homo sapiens_hsa030132.53186447
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32716274
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22995160
10Homologous recombination_Homo sapiens_hsa034402.14662825
11mRNA surveillance pathway_Homo sapiens_hsa030152.11963646
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10479369
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09797014
14Nucleotide excision repair_Homo sapiens_hsa034202.08144764
15Oxidative phosphorylation_Homo sapiens_hsa001902.07439910
16Propanoate metabolism_Homo sapiens_hsa006402.05709305
17Proteasome_Homo sapiens_hsa030502.00488208
18Parkinsons disease_Homo sapiens_hsa050121.97700456
19Ribosome_Homo sapiens_hsa030101.95643517
20RNA polymerase_Homo sapiens_hsa030201.95142482
21One carbon pool by folate_Homo sapiens_hsa006701.78279484
22Steroid biosynthesis_Homo sapiens_hsa001001.71806866
23Non-homologous end-joining_Homo sapiens_hsa034501.71735096
24Fanconi anemia pathway_Homo sapiens_hsa034601.68720452
25RNA degradation_Homo sapiens_hsa030181.68177813
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63574129
27Basal cell carcinoma_Homo sapiens_hsa052171.62827316
28Butanoate metabolism_Homo sapiens_hsa006501.60220748
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57514639
30p53 signaling pathway_Homo sapiens_hsa041151.56037227
31Pyrimidine metabolism_Homo sapiens_hsa002401.53344927
32Fatty acid elongation_Homo sapiens_hsa000621.47260506
33Basal transcription factors_Homo sapiens_hsa030221.47133423
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46494940
35Huntingtons disease_Homo sapiens_hsa050161.45036178
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43034525
37Herpes simplex infection_Homo sapiens_hsa051681.41779380
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41031926
39Viral myocarditis_Homo sapiens_hsa054161.40404124
40Epstein-Barr virus infection_Homo sapiens_hsa051691.37941915
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37427911
42Hippo signaling pathway_Homo sapiens_hsa043901.35631413
43MicroRNAs in cancer_Homo sapiens_hsa052061.35449937
44HTLV-I infection_Homo sapiens_hsa051661.34334763
45Selenocompound metabolism_Homo sapiens_hsa004501.31844399
46Notch signaling pathway_Homo sapiens_hsa043301.29722196
47Systemic lupus erythematosus_Homo sapiens_hsa053221.29628297
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27579240
49Chronic myeloid leukemia_Homo sapiens_hsa052201.25323634
50Viral carcinogenesis_Homo sapiens_hsa052031.24061320
51Colorectal cancer_Homo sapiens_hsa052101.21803159
52Adherens junction_Homo sapiens_hsa045201.18698016
53Small cell lung cancer_Homo sapiens_hsa052221.16775123
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16336170
55Phototransduction_Homo sapiens_hsa047441.15311673
56Antigen processing and presentation_Homo sapiens_hsa046121.12384039
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.11300393
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11223771
59Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05574217
60Hedgehog signaling pathway_Homo sapiens_hsa043401.04174028
61Pyruvate metabolism_Homo sapiens_hsa006201.03369875
62TGF-beta signaling pathway_Homo sapiens_hsa043501.03138469
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01743340
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01543394
65Peroxisome_Homo sapiens_hsa041461.01540050
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00689313
67Measles_Homo sapiens_hsa051621.00483800
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99585110
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97513983
70Legionellosis_Homo sapiens_hsa051340.96200504
71Allograft rejection_Homo sapiens_hsa053300.94095001
72Endometrial cancer_Homo sapiens_hsa052130.93970545
73Primary immunodeficiency_Homo sapiens_hsa053400.93665758
74Regulation of autophagy_Homo sapiens_hsa041400.93615695
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.92039392
76Thyroid cancer_Homo sapiens_hsa052160.90651223
77Hepatitis B_Homo sapiens_hsa051610.90079421
78Alzheimers disease_Homo sapiens_hsa050100.88710306
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.87808810
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.85488533
81Apoptosis_Homo sapiens_hsa042100.85363258
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84122140
83Proteoglycans in cancer_Homo sapiens_hsa052050.83752912
84Oocyte meiosis_Homo sapiens_hsa041140.80297672
85Pancreatic cancer_Homo sapiens_hsa052120.80015783
86Shigellosis_Homo sapiens_hsa051310.79532782
87Leishmaniasis_Homo sapiens_hsa051400.78592242
88Wnt signaling pathway_Homo sapiens_hsa043100.76335628
89Pathways in cancer_Homo sapiens_hsa052000.75365185
90Influenza A_Homo sapiens_hsa051640.74117272
91Prostate cancer_Homo sapiens_hsa052150.73257799
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72420597
93Acute myeloid leukemia_Homo sapiens_hsa052210.70273958
94Non-small cell lung cancer_Homo sapiens_hsa052230.69869805
95Purine metabolism_Homo sapiens_hsa002300.69741043
96Fatty acid metabolism_Homo sapiens_hsa012120.69692306
97Nicotine addiction_Homo sapiens_hsa050330.66496486
98Biosynthesis of amino acids_Homo sapiens_hsa012300.66137338
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.64397926
100Axon guidance_Homo sapiens_hsa043600.62366370
101Toxoplasmosis_Homo sapiens_hsa051450.61428614
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.61370934
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61078176
104Metabolic pathways_Homo sapiens_hsa011000.60847041
105Carbon metabolism_Homo sapiens_hsa012000.59412316
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59331685
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59189618
108Graft-versus-host disease_Homo sapiens_hsa053320.58707882
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57519734
110Focal adhesion_Homo sapiens_hsa045100.57249593
111Bladder cancer_Homo sapiens_hsa052190.57178967
112FoxO signaling pathway_Homo sapiens_hsa040680.56340885
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55341957
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55195286
115Asthma_Homo sapiens_hsa053100.55072120
116beta-Alanine metabolism_Homo sapiens_hsa004100.53976005
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.53859712
118T cell receptor signaling pathway_Homo sapiens_hsa046600.53552003
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53149959
120Alcoholism_Homo sapiens_hsa050340.52807756
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51735443
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51063905
123TNF signaling pathway_Homo sapiens_hsa046680.50749027
124HIF-1 signaling pathway_Homo sapiens_hsa040660.50740519
125Cardiac muscle contraction_Homo sapiens_hsa042600.50513431
126mTOR signaling pathway_Homo sapiens_hsa041500.49711388
127Folate biosynthesis_Homo sapiens_hsa007900.49596699
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.48636681
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48140496
130B cell receptor signaling pathway_Homo sapiens_hsa046620.47969092
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47863976
132Autoimmune thyroid disease_Homo sapiens_hsa053200.47408311
133Melanoma_Homo sapiens_hsa052180.47000600
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46256667
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44552320
136Glutathione metabolism_Homo sapiens_hsa004800.44320532
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.44245972
138N-Glycan biosynthesis_Homo sapiens_hsa005100.43964734
139Tight junction_Homo sapiens_hsa045300.43653728
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42749792
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42288316
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41916003
143Lysine degradation_Homo sapiens_hsa003100.41075381
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40846982
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40182906
146Sulfur metabolism_Homo sapiens_hsa009200.37896550
147Ether lipid metabolism_Homo sapiens_hsa005650.36944941
148Tryptophan metabolism_Homo sapiens_hsa003800.36850061
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34239496
150Taste transduction_Homo sapiens_hsa047420.34022939
151Collecting duct acid secretion_Homo sapiens_hsa049660.32401490
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29911581
153Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28872163
154GABAergic synapse_Homo sapiens_hsa047270.28127810
155Fatty acid degradation_Homo sapiens_hsa000710.27987399
156Dopaminergic synapse_Homo sapiens_hsa047280.27654707
157Cocaine addiction_Homo sapiens_hsa050300.26867500
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26688332
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24132936
160Nitrogen metabolism_Homo sapiens_hsa009100.23622691
161Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21571248
162Arginine and proline metabolism_Homo sapiens_hsa003300.21229980
163Steroid hormone biosynthesis_Homo sapiens_hsa001400.20752201

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