ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	peptidyl-threonine dephosphorylation (GO:0035970)	8.59430176
2	ribosomal small subunit assembly (GO:0000028)	6.19246115
3	behavioral response to nicotine (GO:0035095)	5.69621490
4	regulation of meiosis I (GO:0060631)	5.03733391
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.77494710
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.64739071
7	establishment of protein localization to Golgi (GO:0072600)	4.47813977
8	replication fork processing (GO:0031297)	4.43506056
9	regulation of cilium movement (GO:0003352)	4.33192608
10	protein targeting to Golgi (GO:0000042)	4.25739792
11	positive regulation of meiosis (GO:0045836)	4.04125548
12	positive regulation of male gonad development (GO:2000020)	4.01681241
13	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.95353007
14	single strand break repair (GO:0000012)	3.92484848
15	regulation of feeding behavior (GO:0060259)	3.83442420
16	positive regulation of meiotic cell cycle (GO:0051446)	3.80689842
17	cellular ketone body metabolic process (GO:0046950)	3.79642658
18	ketone body metabolic process (GO:1902224)	3.65661075
19	negative regulation of DNA recombination (GO:0045910)	3.64958016
20	protein localization to Golgi apparatus (GO:0034067)	3.62239332
21	sympathetic nervous system development (GO:0048485)	3.59611868
22	Sertoli cell development (GO:0060009)	3.56443138
23	ncRNA 3-end processing (GO:0043628)	3.50941531
24	chromatin remodeling at centromere (GO:0031055)	3.46205440
25	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.44972704
26	negative regulation of meiosis (GO:0045835)	3.43747907
27	protein polyglutamylation (GO:0018095)	3.43338343
28	CENP-A containing nucleosome assembly (GO:0034080)	3.40524260
29	nucleotide transmembrane transport (GO:1901679)	3.39721745
30	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.37011419
31	pyrimidine dimer repair (GO:0006290)	3.34469659
32	response to pheromone (GO:0019236)	3.31862090
33	oocyte development (GO:0048599)	3.31539443
34	DNA strand renaturation (GO:0000733)	3.31416921
35	ribosomal small subunit biogenesis (GO:0042274)	3.30570436
36	male sex determination (GO:0030238)	3.20327308
37	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.19841558
38	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.19476493
39	regulation of male gonad development (GO:2000018)	3.19394127
40	translational termination (GO:0006415)	3.13535157
41	negative regulation of membrane potential (GO:0045837)	3.01432240
42	protein K6-linked ubiquitination (GO:0085020)	2.98807909
43	viral transcription (GO:0019083)	2.98542607
44	reciprocal DNA recombination (GO:0035825)	2.95399003
45	reciprocal meiotic recombination (GO:0007131)	2.95399003
46	intracellular protein transmembrane import (GO:0044743)	2.94394565
47	phosphorelay signal transduction system (GO:0000160)	2.91074777
48	response to dietary excess (GO:0002021)	2.88466985
49	protein prenylation (GO:0018342)	2.85048776
50	prenylation (GO:0097354)	2.85048776
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.83644987
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.83644987
53	NADH dehydrogenase complex assembly (GO:0010257)	2.83644987
54	preassembly of GPI anchor in ER membrane (GO:0016254)	2.80910142
55	nonmotile primary cilium assembly (GO:0035058)	2.80730995
56	positive regulation of granulocyte differentiation (GO:0030854)	2.78345040
57	negative regulation of response to food (GO:0032096)	2.76621912
58	negative regulation of appetite (GO:0032099)	2.76621912
59	protein import into peroxisome matrix (GO:0016558)	2.76256514
60	regulation of dopamine secretion (GO:0014059)	2.74817191
61	acrosome reaction (GO:0007340)	2.74424703
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.72988253
63	fat-soluble vitamin catabolic process (GO:0042363)	2.72399886
64	vitamin catabolic process (GO:0009111)	2.72399886
65	neurofilament cytoskeleton organization (GO:0060052)	2.72373668
66	DNA deamination (GO:0045006)	2.70435181
67	pyrimidine nucleobase catabolic process (GO:0006208)	2.69211147
68	replicative senescence (GO:0090399)	2.68462458
69	retinal rod cell development (GO:0046548)	2.68133272
70	histone exchange (GO:0043486)	2.67429861
71	recombinational repair (GO:0000725)	2.66514216
72	negative regulation of meiotic cell cycle (GO:0051447)	2.65916650
73	cochlea development (GO:0090102)	2.63467226
74	GTP biosynthetic process (GO:0006183)	2.63293709
75	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61900915
76	brain morphogenesis (GO:0048854)	2.61797571
77	GPI anchor metabolic process (GO:0006505)	2.60844920
78	chaperone-mediated protein transport (GO:0072321)	2.59729813
79	regulation of microtubule-based movement (GO:0060632)	2.56394959
80	rRNA catabolic process (GO:0016075)	2.53040977
81	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.52801974
82	regulation of centriole replication (GO:0046599)	2.51613157
83	regulation of DNA endoreduplication (GO:0032875)	2.51258466
84	protein targeting to lysosome (GO:0006622)	2.50760665
85	establishment of protein localization to vacuole (GO:0072666)	2.50760665
86	protein targeting to vacuole (GO:0006623)	2.50760665
87	platelet dense granule organization (GO:0060155)	2.50273382
88	maturation of SSU-rRNA (GO:0030490)	2.49759781
89	epithelial cilium movement (GO:0003351)	2.49291925
90	regulation of oxidative phosphorylation (GO:0002082)	2.48563600
91	dopamine transport (GO:0015872)	2.46817212
92	microtubule anchoring (GO:0034453)	2.46072700
93	translational elongation (GO:0006414)	2.45904742
94	eating behavior (GO:0042755)	2.45723374
95	DNA damage induced protein phosphorylation (GO:0006975)	2.45687860
96	positive regulation of cellular response to oxidative stress (GO:1900409)	2.43952392
97	positive regulation of response to oxidative stress (GO:1902884)	2.43952392
98	protein K63-linked deubiquitination (GO:0070536)	2.43100758
99	ATP synthesis coupled proton transport (GO:0015986)	2.43031004
100	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.43031004

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.99906143
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.73722196
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.71660381
4	EWS_26573619_Chip-Seq_HEK293_Human	2.64863097
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44638162
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.40725224
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.35320920
8	VDR_22108803_ChIP-Seq_LS180_Human	2.26989226
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.25016461
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.24033134
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.23925611
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.20024702
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.15590641
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.14620702
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.09601815
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.02636397
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.93706955
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87564005
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.86019929
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85556833
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82806613
22	E2F7_22180533_ChIP-Seq_HELA_Human	1.81277196
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76729054
24	FUS_26573619_Chip-Seq_HEK293_Human	1.74737668
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72022104
26	CBP_20019798_ChIP-Seq_JUKART_Human	1.69390363
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69390363
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64671750
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.60717917
30	P300_19829295_ChIP-Seq_ESCs_Human	1.58697059
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56983527
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.53652224
33	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.52629809
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51817325
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48014550
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.47707194
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.47687283
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47429668
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45731825
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43777738
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.43308819
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.42605819
43	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.42253812
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41184705
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36002813
46	STAT3_23295773_ChIP-Seq_U87_Human	1.35654902
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34136627
48	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.33640589
49	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.33409913
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33380368
51	RUNX_20019798_ChIP-Seq_JUKART_Human	1.33293908
52	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.32636161
53	TCF4_23295773_ChIP-Seq_U87_Human	1.31440415
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.30933506
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30614640
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30578611
57	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.28449822
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27951666
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.24760015
60	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.23514479
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22941959
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22941959
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22308712
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21439199
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21207527
66	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21008894
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.19353043
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19289087
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.17308710
70	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.17090688
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.16740440
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16532506
73	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16116366
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.15953479
75	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15582883
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14794145
77	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13214098
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12021295
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11087144
80	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11043990
81	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.08372189
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07266048
83	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06895178
84	JUN_21703547_ChIP-Seq_K562_Human	1.06724275
85	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06008709
86	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.04849478
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.04767370
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03037275
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02963671
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02053151
91	NFYB_21822215_ChIP-Seq_K562_Human	1.01382087
92	TBL1_22424771_ChIP-Seq_293T_Human	1.00775208
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00262349
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00262349
95	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00258639
96	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.00203941
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99753529
98	NFYA_21822215_ChIP-Seq_K562_Human	0.99248977
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.98205642
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97612079

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.02352258
2	MP0006292_abnormal_olfactory_placode	3.35867390
3	MP0005075_abnormal_melanosome_morpholog	2.93596774
4	MP0008877_abnormal_DNA_methylation	2.48827231
5	MP0008995_early_reproductive_senescence	2.47199726
6	MP0008058_abnormal_DNA_repair	2.45698290
7	MP0003787_abnormal_imprinting	2.32616336
8	MP0002095_abnormal_skin_pigmentation	2.29737515
9	MP0003121_genomic_imprinting	2.29500222
10	MP0003786_premature_aging	2.28748350
11	MP0002163_abnormal_gland_morphology	2.25681630
12	MP0003122_maternal_imprinting	2.25567974
13	MP0002160_abnormal_reproductive_system	2.21489883
14	MP0008057_abnormal_DNA_replication	2.15090172
15	MP0002822_catalepsy	2.14209715
16	MP0002638_abnormal_pupillary_reflex	2.10864005
17	MP0000015_abnormal_ear_pigmentation	2.07824842
18	MP0005645_abnormal_hypothalamus_physiol	1.99287521
19	MP0004142_abnormal_muscle_tone	1.94727672
20	MP0008007_abnormal_cellular_replicative	1.90946309
21	MP0001984_abnormal_olfaction	1.88802955
22	MP0002751_abnormal_autonomic_nervous	1.85140180
23	MP0003221_abnormal_cardiomyocyte_apopto	1.78018758
24	MP0005389_reproductive_system_phenotype	1.68262631
25	MP0003195_calcinosis	1.66951551
26	MP0006072_abnormal_retinal_apoptosis	1.58350975
27	MP0005253_abnormal_eye_physiology	1.56248821
28	MP0004147_increased_porphyrin_level	1.54155044
29	MP0010094_abnormal_chromosome_stability	1.53686144
30	MP0005084_abnormal_gallbladder_morpholo	1.51162253
31	MP0001324_abnormal_eye_pigmentation	1.49706283
32	MP0005394_taste/olfaction_phenotype	1.47353049
33	MP0005499_abnormal_olfactory_system	1.47353049
34	MP0004381_abnormal_hair_follicle	1.45012054
35	MP0005551_abnormal_eye_electrophysiolog	1.41689862
36	MP0005379_endocrine/exocrine_gland_phen	1.41659975
37	MP0004134_abnormal_chest_morphology	1.39065195
38	MP0000383_abnormal_hair_follicle	1.38234220
39	MP0005174_abnormal_tail_pigmentation	1.38094772
40	MP0002653_abnormal_ependyma_morphology	1.35048015
41	MP0004885_abnormal_endolymph	1.33064363
42	MP0006276_abnormal_autonomic_nervous	1.28729763
43	MP0002876_abnormal_thyroid_physiology	1.28637087
44	MP0000427_abnormal_hair_cycle	1.26556072
45	MP0008789_abnormal_olfactory_epithelium	1.26506931
46	MP0002938_white_spotting	1.25196088
47	MP0000372_irregular_coat_pigmentation	1.23333396
48	MP0004742_abnormal_vestibular_system	1.20682747
49	MP0005408_hypopigmentation	1.19241899
50	MP0002009_preneoplasia	1.12815323
51	MP0005083_abnormal_biliary_tract	1.12333779
52	MP0001485_abnormal_pinna_reflex	1.11237259
53	MP0002102_abnormal_ear_morphology	1.11215367
54	MP0003936_abnormal_reproductive_system	1.08197465
55	MP0009745_abnormal_behavioral_response	1.07643836
56	MP0003950_abnormal_plasma_membrane	1.06000670
57	MP0002837_dystrophic_cardiac_calcinosis	1.05440924
58	MP0005187_abnormal_penis_morphology	1.05224980
59	MP0000647_abnormal_sebaceous_gland	1.05148710
60	MP0008872_abnormal_physiological_respon	1.01962024
61	MP0002733_abnormal_thermal_nociception	1.01243447
62	MP0002210_abnormal_sex_determination	1.00792377
63	MP0004145_abnormal_muscle_electrophysio	1.00667842
64	MP0001502_abnormal_circadian_rhythm	1.00312069
65	MP0003693_abnormal_embryo_hatching	0.99561672
66	MP0008569_lethality_at_weaning	0.98622698
67	MP0003567_abnormal_fetal_cardiomyocyte	0.95639589
68	MP0001929_abnormal_gametogenesis	0.95433803
69	MP0010678_abnormal_skin_adnexa	0.95413879
70	MP0002928_abnormal_bile_duct	0.95168502
71	MP0003890_abnormal_embryonic-extraembry	0.95038774
72	MP0003123_paternal_imprinting	0.93367319
73	MP0000371_diluted_coat_color	0.91654285
74	MP0002557_abnormal_social/conspecific_i	0.90777150
75	MP0004133_heterotaxia	0.90418013
76	MP0002234_abnormal_pharynx_morphology	0.89839479
77	MP0003698_abnormal_male_reproductive	0.85408599
78	MP0000653_abnormal_sex_gland	0.84983725
79	MP0002063_abnormal_learning/memory/cond	0.84365525
80	MP0001970_abnormal_pain_threshold	0.84011511
81	MP0005391_vision/eye_phenotype	0.83562333
82	MP0001145_abnormal_male_reproductive	0.82320106
83	MP0002127_abnormal_cardiovascular_syste	0.81761201
84	MP0003937_abnormal_limbs/digits/tail_de	0.81195373
85	MP0001905_abnormal_dopamine_level	0.81069559
86	MP0003635_abnormal_synaptic_transmissio	0.80745050
87	MP0002006_tumorigenesis	0.80442389
88	MP0003646_muscle_fatigue	0.77558304
89	MP0002735_abnormal_chemical_nociception	0.77452963
90	MP0005195_abnormal_posterior_eye	0.77171210
91	MP0009046_muscle_twitch	0.76538513
92	MP0002229_neurodegeneration	0.76016010
93	MP0000049_abnormal_middle_ear	0.75924088
94	MP0002272_abnormal_nervous_system	0.74810639
95	MP0005266_abnormal_metabolism	0.73014875
96	MP0002572_abnormal_emotion/affect_behav	0.68189228
97	MP0002734_abnormal_mechanical_nocicepti	0.65942486
98	MP0000778_abnormal_nervous_system	0.65939537
99	MP0001486_abnormal_startle_reflex	0.65875703
100	MP0002752_abnormal_somatic_nervous	0.65668131

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.85954732
2	Reticulocytopenia (HP:0001896)	3.80118077
3	Duplicated collecting system (HP:0000081)	3.59771319
4	Abnormality of DNA repair (HP:0003254)	3.56057507
5	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.55250958
6	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.55250958
7	Abnormality of the renal collecting system (HP:0004742)	3.49997591
8	Progressive macrocephaly (HP:0004481)	3.39540842
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.27206045
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.18565287
11	Osteomalacia (HP:0002749)	3.13116380
12	Acute encephalopathy (HP:0006846)	3.10304360
13	Mitochondrial inheritance (HP:0001427)	3.08923156
14	Chromsome breakage (HP:0040012)	3.06876314
15	Supernumerary spleens (HP:0009799)	3.06658482
16	Abnormality of renal resorption (HP:0011038)	3.03052551
17	Abnormality of the renal cortex (HP:0011035)	2.99037894
18	True hermaphroditism (HP:0010459)	2.95024295
19	Pancreatic cysts (HP:0001737)	2.86602512
20	Increased CSF lactate (HP:0002490)	2.80209676
21	Central scotoma (HP:0000603)	2.77620548
22	Postaxial foot polydactyly (HP:0001830)	2.71921571
23	Renal Fanconi syndrome (HP:0001994)	2.69688252
24	Abnormality of the corticospinal tract (HP:0002492)	2.61485324
25	Cerebral edema (HP:0002181)	2.59325074
26	Chronic hepatic failure (HP:0100626)	2.57737383
27	Increased hepatocellular lipid droplets (HP:0006565)	2.56693399
28	Pancreatic fibrosis (HP:0100732)	2.53364750
29	Hepatocellular necrosis (HP:0001404)	2.50230858
30	Medial flaring of the eyebrow (HP:0010747)	2.49113468
31	Synostosis of carpal bones (HP:0005048)	2.40467948
32	Fair hair (HP:0002286)	2.33773911
33	Agitation (HP:0000713)	2.32045277
34	Gait imbalance (HP:0002141)	2.30521928
35	Tubulointerstitial fibrosis (HP:0005576)	2.28956444
36	Abnormal hair whorl (HP:0010721)	2.28835401
37	Abnormality of chromosome stability (HP:0003220)	2.28644700
38	Optic disc pallor (HP:0000543)	2.27781402
39	Hepatic necrosis (HP:0002605)	2.27297012
40	Lipid accumulation in hepatocytes (HP:0006561)	2.22365155
41	Abnormality of the pons (HP:0007361)	2.21036294
42	Volvulus (HP:0002580)	2.19599922
43	Asplenia (HP:0001746)	2.19571844
44	Congenital primary aphakia (HP:0007707)	2.18876100
45	Thyroiditis (HP:0100646)	2.18418020
46	Tubular atrophy (HP:0000092)	2.17811686
47	Abnormality of midbrain morphology (HP:0002418)	2.16489245
48	Molar tooth sign on MRI (HP:0002419)	2.16489245
49	Abnormality of the renal medulla (HP:0100957)	2.15302978
50	Colon cancer (HP:0003003)	2.13752221
51	Impulsivity (HP:0100710)	2.12439773
52	Hyperphosphatemia (HP:0002905)	2.11812558
53	Congenital stationary night blindness (HP:0007642)	2.06769179
54	Tubulointerstitial abnormality (HP:0001969)	2.04662144
55	Sloping forehead (HP:0000340)	2.03556194
56	Sclerocornea (HP:0000647)	2.03282872
57	Abnormal biliary tract physiology (HP:0012439)	2.02546015
58	Bile duct proliferation (HP:0001408)	2.02546015
59	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.00963139
60	Generalized hypopigmentation of hair (HP:0011358)	2.00562856
61	Anencephaly (HP:0002323)	2.00343829
62	Septate vagina (HP:0001153)	1.96839896
63	Nephrogenic diabetes insipidus (HP:0009806)	1.95266433
64	Urinary bladder sphincter dysfunction (HP:0002839)	1.93655480
65	Male pseudohermaphroditism (HP:0000037)	1.90909329
66	Hypoplasia of the pons (HP:0012110)	1.90489487
67	Absent thumb (HP:0009777)	1.89976210
68	Glycosuria (HP:0003076)	1.89750573
69	Abnormality of urine glucose concentration (HP:0011016)	1.89750573
70	Abnormality of alanine metabolism (HP:0010916)	1.88802417
71	Hyperalaninemia (HP:0003348)	1.88802417
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88802417
73	Nephronophthisis (HP:0000090)	1.88387768
74	Aplasia cutis congenita (HP:0001057)	1.87890875
75	Fetal akinesia sequence (HP:0001989)	1.87629240
76	Absent radius (HP:0003974)	1.86389153
77	Ectopic kidney (HP:0000086)	1.85165096
78	Poikiloderma (HP:0001029)	1.85078220
79	Gaze-evoked nystagmus (HP:0000640)	1.82032215
80	Cortical dysplasia (HP:0002539)	1.81155355
81	Poor coordination (HP:0002370)	1.79008112
82	Constricted visual fields (HP:0001133)	1.76455096
83	Macrocytic anemia (HP:0001972)	1.75923979
84	Abnormality of pyrimidine metabolism (HP:0004353)	1.75606142
85	Scotoma (HP:0000575)	1.73216052
86	Absent forearm bone (HP:0003953)	1.71833980
87	Aplasia involving forearm bones (HP:0009822)	1.71833980
88	Abnormality of the ileum (HP:0001549)	1.71040075
89	Rectal fistula (HP:0100590)	1.69913855
90	Rectovaginal fistula (HP:0000143)	1.69913855
91	Pancytopenia (HP:0001876)	1.69679031
92	Abnormality of macular pigmentation (HP:0008002)	1.69343765
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69220839
94	Abnormal pancreas size (HP:0012094)	1.68900250
95	T lymphocytopenia (HP:0005403)	1.68759745
96	Abnormality of abdominal situs (HP:0011620)	1.68554470
97	Abdominal situs inversus (HP:0003363)	1.68554470
98	Cystic liver disease (HP:0006706)	1.67256242
99	Birth length less than 3rd percentile (HP:0003561)	1.66129572
100	Rhinitis (HP:0012384)	1.66068946

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	5.36759805
2	FRK	3.41857222
3	WNK4	3.26934910
4	ZAK	2.80492142
5	INSRR	2.43958643
6	PNCK	2.37397548
7	TAOK3	2.12645151
8	PASK	2.08131136
9	MAP3K4	2.07870295
10	CDK19	1.85078707
11	NUAK1	1.71133868
12	MAP2K7	1.65749877
13	PLK2	1.62500570
14	STK39	1.62203319
15	STK16	1.61399648
16	TLK1	1.59892951
17	CDC7	1.56292363
18	MKNK2	1.47657398
19	PDK2	1.45953376
20	DYRK2	1.40963349
21	BCR	1.24836522
22	MUSK	1.20018837
23	GRK1	1.19304620
24	MAPK13	1.17599467
25	ADRBK2	1.16971696
26	MAP4K2	1.16335483
27	WEE1	1.10294458
28	WNK1	1.05846374
29	TXK	1.04018582
30	OXSR1	0.99547821
31	ATR	0.97686923
32	OBSCN	0.97536521
33	PINK1	0.94390434
34	PKN2	0.92869180
35	CSNK1G3	0.92559959
36	WNK3	0.92546937
37	DYRK1B	0.90402074
38	TGFBR1	0.90335703
39	IRAK1	0.89797078
40	PLK4	0.89213118
41	SYK	0.88488911
42	RPS6KA5	0.88035921
43	BCKDK	0.86944389
44	ERBB3	0.86902992
45	FGR	0.84757707
46	TEC	0.82464056
47	VRK1	0.81133998
48	RPS6KB2	0.79915354
49	DYRK1A	0.79594223
50	CSNK1G1	0.77359062
51	CSNK1G2	0.76761438
52	PIM1	0.76405123
53	FLT3	0.74655702
54	MAPK15	0.74133024
55	CSNK1D	0.72092268
56	CSNK1A1L	0.70709456
57	PLK3	0.70213531
58	PRKCQ	0.67662300
59	EIF2AK3	0.66601661
60	GRK5	0.66047884
61	PBK	0.65766749
62	MAP2K4	0.65538865
63	MAPK12	0.64996066
64	ATM	0.64789705
65	DYRK3	0.62749082
66	ALK	0.62619434
67	CHEK1	0.62159654
68	NEK2	0.61907959
69	ADRBK1	0.60025739
70	BTK	0.59568291
71	PRKACA	0.57273758
72	PLK1	0.56973156
73	CAMK4	0.56506771
74	IKBKB	0.55797179
75	GRK6	0.54164423
76	CDK9	0.51423484
77	SGK1	0.51412769
78	MKNK1	0.50360934
79	ACVR1B	0.50068042
80	PHKG1	0.49973986
81	PHKG2	0.49973986
82	STK11	0.48464817
83	AURKB	0.48166687
84	RPS6KA4	0.47289006
85	ITK	0.45851168
86	TRPM7	0.45766140
87	ERBB2	0.45732741
88	IKBKE	0.44769558
89	CASK	0.44340303
90	MAPKAPK3	0.42044270
91	PIK3CG	0.41967618
92	CDK8	0.41309708
93	CAMK1G	0.41078055
94	MARK1	0.40720484
95	NLK	0.40523387
96	MARK2	0.39797198
97	PRKCG	0.39789622
98	RPS6KA3	0.38801707
99	CSNK1A1	0.38753370
100	MAP3K10	0.37497700

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.69569380
2	Ribosome_Homo sapiens_hsa03010	3.66104440
3	Parkinsons disease_Homo sapiens_hsa05012	3.52961728
4	Homologous recombination_Homo sapiens_hsa03440	3.37394226
5	Fanconi anemia pathway_Homo sapiens_hsa03460	3.15079480
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.55927526
7	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.44805139
8	Huntingtons disease_Homo sapiens_hsa05016	2.18884080
9	Mismatch repair_Homo sapiens_hsa03430	2.14782114
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.13598892
11	DNA replication_Homo sapiens_hsa03030	2.12962329
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.09947292
13	Alzheimers disease_Homo sapiens_hsa05010	2.00497519
14	Nucleotide excision repair_Homo sapiens_hsa03420	1.97007064
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.91943095
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.84268295
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.80752653
18	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.78373514
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75977313
20	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.75438832
21	Alcoholism_Homo sapiens_hsa05034	1.73376780
22	Nicotine addiction_Homo sapiens_hsa05033	1.68551799
23	Taste transduction_Homo sapiens_hsa04742	1.67794417
24	Base excision repair_Homo sapiens_hsa03410	1.51151140
25	Phototransduction_Homo sapiens_hsa04744	1.45391784
26	RNA degradation_Homo sapiens_hsa03018	1.45327796
27	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.36347164
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28453364
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.27832100
30	RNA transport_Homo sapiens_hsa03013	1.21012010
31	Folate biosynthesis_Homo sapiens_hsa00790	1.20925864
32	Basal transcription factors_Homo sapiens_hsa03022	1.19632614
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.19506806
34	Peroxisome_Homo sapiens_hsa04146	1.19065510
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.15950579
36	Collecting duct acid secretion_Homo sapiens_hsa04966	1.15658526
37	Olfactory transduction_Homo sapiens_hsa04740	1.12961990
38	p53 signaling pathway_Homo sapiens_hsa04115	1.09063860
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.05085252
40	One carbon pool by folate_Homo sapiens_hsa00670	1.02592244
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00211465
42	Purine metabolism_Homo sapiens_hsa00230	0.97315700
43	Butanoate metabolism_Homo sapiens_hsa00650	0.96016140
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.95347213
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.93104255
46	RNA polymerase_Homo sapiens_hsa03020	0.91989742
47	Melanoma_Homo sapiens_hsa05218	0.90700243
48	Morphine addiction_Homo sapiens_hsa05032	0.86624920
49	Serotonergic synapse_Homo sapiens_hsa04726	0.82936401
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.82674432
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82407504
52	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.78633860
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.77139329
54	Propanoate metabolism_Homo sapiens_hsa00640	0.66744559
55	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.65822857
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.65558017
57	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.62939874
58	Metabolic pathways_Homo sapiens_hsa01100	0.61346620
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59994280
60	Lysine degradation_Homo sapiens_hsa00310	0.58818932
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57990971
62	Primary immunodeficiency_Homo sapiens_hsa05340	0.57801874
63	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54323951
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54138689
65	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.51102061
66	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.48802156
67	Insulin secretion_Homo sapiens_hsa04911	0.48232570
68	Cholinergic synapse_Homo sapiens_hsa04725	0.47196654
69	Caffeine metabolism_Homo sapiens_hsa00232	0.46078938
70	Spliceosome_Homo sapiens_hsa03040	0.45706128
71	Cocaine addiction_Homo sapiens_hsa05030	0.45090358
72	Salivary secretion_Homo sapiens_hsa04970	0.44704042
73	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43279117
74	MAPK signaling pathway_Homo sapiens_hsa04010	0.41000456
75	Proteasome_Homo sapiens_hsa03050	0.40747918
76	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38940682
77	Glutamatergic synapse_Homo sapiens_hsa04724	0.38291611
78	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.38236369
79	Fatty acid elongation_Homo sapiens_hsa00062	0.37893264
80	Renin secretion_Homo sapiens_hsa04924	0.37403477
81	Ras signaling pathway_Homo sapiens_hsa04014	0.37392373
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36786563
83	GABAergic synapse_Homo sapiens_hsa04727	0.36706309
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35088241
85	Retinol metabolism_Homo sapiens_hsa00830	0.34732007
86	Viral carcinogenesis_Homo sapiens_hsa05203	0.34432032
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34416598
88	Renin-angiotensin system_Homo sapiens_hsa04614	0.33559329
89	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.33152822
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32136598
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29905050
92	Choline metabolism in cancer_Homo sapiens_hsa05231	0.28673953
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.26413072
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.25536406
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.22763528
96	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.22670393
97	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.22542864
98	Chemical carcinogenesis_Homo sapiens_hsa05204	0.21750089
99	Regulation of autophagy_Homo sapiens_hsa04140	0.21508112
100	Cell cycle_Homo sapiens_hsa04110	0.21418643

SMARCE1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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