ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	5.42601386
2	L-fucose metabolic process (GO:0042354)	5.42601386
3	L-fucose catabolic process (GO:0042355)	5.42601386
4	base-excision repair, AP site formation (GO:0006285)	5.05230941
5	DNA deamination (GO:0045006)	4.57642800
6	negative regulation of mast cell activation (GO:0033004)	4.50616770
7	negative regulation of telomere maintenance (GO:0032205)	4.47103210
8	cardiac right ventricle morphogenesis (GO:0003215)	4.36842136
9	fusion of sperm to egg plasma membrane (GO:0007342)	4.05654760
10	platelet dense granule organization (GO:0060155)	4.03552275
11	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.01871749
12	protein K6-linked ubiquitination (GO:0085020)	3.85857645
13	protein deneddylation (GO:0000338)	3.80893914
14	multicellular organism reproduction (GO:0032504)	3.75897365
15	axoneme assembly (GO:0035082)	3.71591377
16	fucosylation (GO:0036065)	3.68981902
17	piRNA metabolic process (GO:0034587)	3.68275075
18	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.65469475
19	cullin deneddylation (GO:0010388)	3.63586705
20	ATP synthesis coupled proton transport (GO:0015986)	3.53445295
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.53445295
22	respiratory chain complex IV assembly (GO:0008535)	3.50584758
23	S-adenosylmethionine metabolic process (GO:0046500)	3.49225250
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.43985774
25	pharyngeal system development (GO:0060037)	3.41053946
26	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.37390685
27	regulation of cardioblast proliferation (GO:0003264)	3.37390685
28	dopamine transport (GO:0015872)	3.36728259
29	neuronal action potential propagation (GO:0019227)	3.35234783
30	nucleoside transmembrane transport (GO:1901642)	3.34749196
31	sulfation (GO:0051923)	3.27348875
32	plasma membrane fusion (GO:0045026)	3.23363628
33	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.21418971
34	heart field specification (GO:0003128)	3.18558796
35	secondary heart field specification (GO:0003139)	3.18558796
36	negative regulation of membrane potential (GO:0045837)	3.16459205
37	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.16330667
38	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.07334144
39	positive regulation of fatty acid oxidation (GO:0046321)	2.97525577
40	vitamin transmembrane transport (GO:0035461)	2.97235035
41	rhodopsin mediated signaling pathway (GO:0016056)	2.93519618
42	somite development (GO:0061053)	2.93285427
43	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.92950888
44	fatty acid transmembrane transport (GO:1902001)	2.88428757
45	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.84941751
46	cardiac ventricle morphogenesis (GO:0003208)	2.83359804
47	protein neddylation (GO:0045116)	2.82624317
48	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.82336140
49	behavioral response to ethanol (GO:0048149)	2.80569623
50	proteasome assembly (GO:0043248)	2.79955615
51	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.77097048
52	adenosine metabolic process (GO:0046085)	2.76847985
53	cytochrome complex assembly (GO:0017004)	2.73120730
54	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.70960491
55	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.70960491
56	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.70960491
57	positive thymic T cell selection (GO:0045059)	2.70503467
58	carnitine shuttle (GO:0006853)	2.70049547
59	positive regulation of catecholamine secretion (GO:0033605)	2.69900175
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.69294174
61	DNA methylation involved in gamete generation (GO:0043046)	2.67170695
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.65980850
63	ketone body metabolic process (GO:1902224)	2.65391177
64	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.65213458
65	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.65213458
66	pseudouridine synthesis (GO:0001522)	2.64628388
67	retinal ganglion cell axon guidance (GO:0031290)	2.64587072
68	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.63518894
69	positive regulation of antigen processing and presentation (GO:0002579)	2.63171445
70	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.62785749
71	inositol phosphate dephosphorylation (GO:0046855)	2.62785749
72	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.62030479
73	outflow tract septum morphogenesis (GO:0003148)	2.59300799
74	inactivation of MAPK activity (GO:0000188)	2.57633361
75	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.56241441
76	cardiac left ventricle morphogenesis (GO:0003214)	2.55141947
77	carnitine transmembrane transport (GO:1902603)	2.54726603
78	negative regulation of multicellular organism growth (GO:0040015)	2.54589636
79	purine deoxyribonucleotide catabolic process (GO:0009155)	2.54496842
80	negative regulation of activin receptor signaling pathway (GO:0032926)	2.53778838
81	reproduction (GO:0000003)	2.53692996
82	natural killer cell activation involved in immune response (GO:0002323)	2.52747220
83	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.52674690
84	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.52674690
85	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.52530345
86	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.52327497
87	negative regulation of neurological system process (GO:0031645)	2.51588247
88	positive T cell selection (GO:0043368)	2.50760613
89	regulation of dopamine secretion (GO:0014059)	2.47733625
90	inositol phosphate catabolic process (GO:0071545)	2.47628356
91	mannosylation (GO:0097502)	2.46890899
92	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.45857508
93	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.45857508
94	negative regulation of execution phase of apoptosis (GO:1900118)	2.45594181
95	negative regulation of JAK-STAT cascade (GO:0046426)	2.45167928
96	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.44632552
97	anterograde synaptic vesicle transport (GO:0048490)	2.43013716
98	carnitine transport (GO:0015879)	2.42238696
99	amino-acid betaine transport (GO:0015838)	2.42238696
100	electron transport chain (GO:0022900)	2.41939981

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.52925814
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.84416710
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.57857695
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.52301196
5	VDR_22108803_ChIP-Seq_LS180_Human	3.48395436
6	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.22944249
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.05819062
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.88281294
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.83316036
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.69288925
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.56980429
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.50987692
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40359852
14	IRF1_19129219_ChIP-ChIP_H3396_Human	2.22663001
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.09580821
16	EWS_26573619_Chip-Seq_HEK293_Human	2.06744362
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.05656440
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.97222406
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.84788759
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.83330120
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81324927
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77036743
23	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.75491262
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.69282683
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.67656007
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64402915
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61401596
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.60116370
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.57983953
30	HTT_18923047_ChIP-ChIP_STHdh_Human	1.56199662
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54457294
32	P300_19829295_ChIP-Seq_ESCs_Human	1.54072528
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51298131
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.49331088
35	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.47779821
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47383821
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.44451325
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.44261835
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43635652
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.42190842
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.41287711
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38225667
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37612167
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37465350
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37465350
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.35417863
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33902214
48	FUS_26573619_Chip-Seq_HEK293_Human	1.33437712
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33215516
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33215516
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.30909864
52	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30544850
53	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30032486
54	BCAT_22108803_ChIP-Seq_LS180_Human	1.28430903
55	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28072480
56	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27566458
57	NCOR_22424771_ChIP-Seq_293T_Human	1.26953338
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26484591
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.26127310
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26127310
61	GATA3_26560356_Chip-Seq_TH2_Human	1.21229619
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16948505
63	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16374601
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14834449
65	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14403010
66	ETV1_20927104_ChIP-Seq_GIST48_Human	1.13213011
67	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12878471
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12707944
69	PHF8_20622853_ChIP-Seq_HELA_Human	1.12046761
70	NFYB_21822215_ChIP-Seq_K562_Human	1.11955263
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.11501190
72	NFYA_21822215_ChIP-Seq_K562_Human	1.10663908
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10462337
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.09453068
75	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.09265938
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.08811991
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08101768
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07674345
79	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06489147
80	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05026781
81	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.03889665
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.02942524
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02939824
84	AR_20517297_ChIP-Seq_VCAP_Human	1.02552002
85	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01510026
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00455077
87	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.00357890
88	ERA_21632823_ChIP-Seq_H3396_Human	0.99510406
89	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.98189775
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96930736
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95837830
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95585951
93	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95000487
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94501217
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.94295530
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.93665009
97	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.93115893
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92873174
99	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.91881171
100	AR_25329375_ChIP-Seq_VCAP_Human	0.90436377

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.54924602
2	MP0005646_abnormal_pituitary_gland	2.92020804
3	MP0006292_abnormal_olfactory_placode	2.77532910
4	MP0003195_calcinosis	2.65084994
5	MP0005645_abnormal_hypothalamus_physiol	2.55788694
6	MP0006072_abnormal_retinal_apoptosis	2.49780160
7	MP0004885_abnormal_endolymph	2.45883048
8	MP0008995_early_reproductive_senescence	2.42585765
9	MP0001501_abnormal_sleep_pattern	2.33549002
10	MP0002102_abnormal_ear_morphology	2.21621054
11	MP0002160_abnormal_reproductive_system	2.18287539
12	MP0001984_abnormal_olfaction	2.15598629
13	MP0003786_premature_aging	2.06926861
14	MP0000427_abnormal_hair_cycle	2.04897148
15	MP0002751_abnormal_autonomic_nervous	1.99440386
16	MP0000613_abnormal_salivary_gland	1.98284617
17	MP0003724_increased_susceptibility_to	1.95917073
18	MP0002095_abnormal_skin_pigmentation	1.95785516
19	MP0005075_abnormal_melanosome_morpholog	1.91493378
20	MP0002234_abnormal_pharynx_morphology	1.90338325
21	MP0005389_reproductive_system_phenotype	1.87090492
22	MP0008872_abnormal_physiological_respon	1.85916490
23	MP0003136_yellow_coat_color	1.83983785
24	MP0003011_delayed_dark_adaptation	1.79232045
25	MP0005377_hearing/vestibular/ear_phenot	1.77914665
26	MP0003878_abnormal_ear_physiology	1.77914665
27	MP0000631_abnormal_neuroendocrine_gland	1.76578695
28	MP0008875_abnormal_xenobiotic_pharmacok	1.76526556
29	MP0004043_abnormal_pH_regulation	1.75892595
30	MP0002277_abnormal_respiratory_mucosa	1.75847746
31	MP0003806_abnormal_nucleotide_metabolis	1.75693685
32	MP0001968_abnormal_touch/_nociception	1.75152684
33	MP0005671_abnormal_response_to	1.68711937
34	MP0002638_abnormal_pupillary_reflex	1.61923994
35	MP0009780_abnormal_chondrocyte_physiolo	1.59052050
36	MP0005551_abnormal_eye_electrophysiolog	1.51209764
37	MP0003880_abnormal_central_pattern	1.49646186
38	MP0000647_abnormal_sebaceous_gland	1.49384049
39	MP0003122_maternal_imprinting	1.48025122
40	MP0002282_abnormal_trachea_morphology	1.46443203
41	MP0009745_abnormal_behavioral_response	1.45282111
42	MP0002138_abnormal_hepatobiliary_system	1.40538610
43	MP0005083_abnormal_biliary_tract	1.38290323
44	MP0005253_abnormal_eye_physiology	1.28585032
45	MP0003938_abnormal_ear_development	1.27477809
46	MP0002876_abnormal_thyroid_physiology	1.26170447
47	MP0000049_abnormal_middle_ear	1.25379004
48	MP0002272_abnormal_nervous_system	1.21291255
49	MP0001502_abnormal_circadian_rhythm	1.20918433
50	MP0010030_abnormal_orbit_morphology	1.20689566
51	MP0005174_abnormal_tail_pigmentation	1.20487621
52	MP0000685_abnormal_immune_system	1.20092483
53	MP0003718_maternal_effect	1.20022066
54	MP0004742_abnormal_vestibular_system	1.17717108
55	MP0002837_dystrophic_cardiac_calcinosis	1.15812189
56	MP0009764_decreased_sensitivity_to	1.13868728
57	MP0001919_abnormal_reproductive_system	1.11995617
58	MP0001835_abnormal_antigen_presentation	1.06928167
59	MP0002736_abnormal_nociception_after	1.05624604
60	MP0001188_hyperpigmentation	1.04486278
61	MP0001293_anophthalmia	1.02873046
62	MP0002148_abnormal_hypersensitivity_rea	1.00148549
63	MP0002733_abnormal_thermal_nociception	0.99951871
64	MP0001764_abnormal_homeostasis	0.97413566
65	MP0008789_abnormal_olfactory_epithelium	0.95602917
66	MP0001905_abnormal_dopamine_level	0.93261553
67	MP0001970_abnormal_pain_threshold	0.90312426
68	MP0004381_abnormal_hair_follicle	0.90168981
69	MP0004133_heterotaxia	0.89705359
70	MP0005332_abnormal_amino_acid	0.88856383
71	MP0009046_muscle_twitch	0.87735747
72	MP0001790_abnormal_immune_system	0.86720855
73	MP0005387_immune_system_phenotype	0.86720855
74	MP0001986_abnormal_taste_sensitivity	0.85848720
75	MP0001243_abnormal_dermal_layer	0.84483570
76	MP0005248_abnormal_Harderian_gland	0.84066651
77	MP0003121_genomic_imprinting	0.82797442
78	MP0006276_abnormal_autonomic_nervous	0.82475606
79	MP0008775_abnormal_heart_ventricle	0.80967899
80	MP0001800_abnormal_humoral_immune	0.79543423
81	MP0001727_abnormal_embryo_implantation	0.79125337
82	MP0008961_abnormal_basal_metabolism	0.74287647
83	MP0005187_abnormal_penis_morphology	0.73704622
84	MP0004147_increased_porphyrin_level	0.71472403
85	MP0000516_abnormal_urinary_system	0.71339933
86	MP0005367_renal/urinary_system_phenotyp	0.71339933
87	MP0003111_abnormal_nucleus_morphology	0.67401932
88	MP0008877_abnormal_DNA_methylation	0.64195613
89	MP0003638_abnormal_response/metabolism_	0.63421516
90	MP0000383_abnormal_hair_follicle	0.63418294
91	MP0002184_abnormal_innervation	0.63088406
92	MP0002229_neurodegeneration	0.62298358
93	MP0005195_abnormal_posterior_eye	0.62161151
94	MP0001485_abnormal_pinna_reflex	0.61593896
95	MP0002752_abnormal_somatic_nervous	0.61441494
96	MP0002557_abnormal_social/conspecific_i	0.61074149
97	MP0004484_altered_response_of	0.60685938
98	MP0009765_abnormal_xenobiotic_induced	0.60527557
99	MP0005334_abnormal_fat_pad	0.60292854
100	MP0002653_abnormal_ependyma_morphology	0.60178150

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.60789754
2	Type II lissencephaly (HP:0007260)	4.35922028
3	Retinal dysplasia (HP:0007973)	3.95122660
4	Pancreatic fibrosis (HP:0100732)	3.70122185
5	Hypomagnesemia (HP:0002917)	3.65756621
6	True hermaphroditism (HP:0010459)	3.27130339
7	Abnormality of the renal cortex (HP:0011035)	3.20984346
8	Pancreatic cysts (HP:0001737)	3.13612903
9	Acute encephalopathy (HP:0006846)	3.10813275
10	Acute necrotizing encephalopathy (HP:0006965)	3.06647733
11	Hyperglycinemia (HP:0002154)	3.04358185
12	Metabolic alkalosis (HP:0200114)	2.96575515
13	Prostate neoplasm (HP:0100787)	2.95100715
14	Lissencephaly (HP:0001339)	2.88468029
15	Absent speech (HP:0001344)	2.86043721
16	Lipid accumulation in hepatocytes (HP:0006561)	2.83560178
17	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.83093906
18	Abnormal rod and cone electroretinograms (HP:0008323)	2.81945263
19	Abnormality of the prostate (HP:0008775)	2.72690912
20	Abnormality of midbrain morphology (HP:0002418)	2.70468462
21	Molar tooth sign on MRI (HP:0002419)	2.70468462
22	Progressive macrocephaly (HP:0004481)	2.68843307
23	Hypoproteinemia (HP:0003075)	2.66500603
24	Abnormality of magnesium homeostasis (HP:0004921)	2.66256425
25	Renal cortical cysts (HP:0000803)	2.60933771
26	Polyuria (HP:0000103)	2.60092852
27	Hypokalemic alkalosis (HP:0001949)	2.59776779
28	Delayed CNS myelination (HP:0002188)	2.59327799
29	Attenuation of retinal blood vessels (HP:0007843)	2.57065317
30	IgG deficiency (HP:0004315)	2.56553226
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.55983776
32	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.53499626
33	Small intestinal stenosis (HP:0012848)	2.49126840
34	Duodenal stenosis (HP:0100867)	2.49126840
35	Abnormality of the fovea (HP:0000493)	2.48001115
36	Abolished electroretinogram (ERG) (HP:0000550)	2.47860522
37	Renal salt wasting (HP:0000127)	2.44685025
38	Generalized aminoaciduria (HP:0002909)	2.42725990
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40153521
40	Abnormality of macular pigmentation (HP:0008002)	2.32493413
41	Cystic liver disease (HP:0006706)	2.32173382
42	Mitochondrial inheritance (HP:0001427)	2.30978288
43	Increased CSF lactate (HP:0002490)	2.30591404
44	Type 2 muscle fiber atrophy (HP:0003554)	2.30174357
45	Alkalosis (HP:0001948)	2.19997121
46	Pendular nystagmus (HP:0012043)	2.18867836
47	3-Methylglutaconic aciduria (HP:0003535)	2.16022655
48	Abnormal urine output (HP:0012590)	2.15783410
49	Increased hepatocellular lipid droplets (HP:0006565)	2.13329562
50	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.13125771
51	Hypoplasia of the uterus (HP:0000013)	2.12875683
52	Hyperglycinuria (HP:0003108)	2.12548196
53	Aplasia/hypoplasia of the uterus (HP:0008684)	2.12411195
54	Cerebellar dysplasia (HP:0007033)	2.10166842
55	Hypoplasia of the fovea (HP:0007750)	2.09790778
56	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.09790778
57	Optic disc pallor (HP:0000543)	2.09705536
58	Anophthalmia (HP:0000528)	2.08711990
59	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.08683133
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.08367671
61	Abnormality of alanine metabolism (HP:0010916)	2.08232973
62	Hyperalaninemia (HP:0003348)	2.08232973
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08232973
64	Anencephaly (HP:0002323)	2.02566848
65	Severe muscular hypotonia (HP:0006829)	1.99494478
66	Constricted visual fields (HP:0001133)	1.99313732
67	Medial flaring of the eyebrow (HP:0010747)	1.99053791
68	Abnormality of the duodenum (HP:0002246)	1.98620013
69	Increased muscle lipid content (HP:0009058)	1.98326560
70	Absent/shortened dynein arms (HP:0200106)	1.97093581
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97093581
72	Hyperventilation (HP:0002883)	1.95999141
73	Increased serum lactate (HP:0002151)	1.95918358
74	Abnormality of urine glucose concentration (HP:0011016)	1.90707015
75	Glycosuria (HP:0003076)	1.90707015
76	Lethargy (HP:0001254)	1.90643573
77	Annular pancreas (HP:0001734)	1.90512781
78	Sclerocornea (HP:0000647)	1.90197236
79	Bicornuate uterus (HP:0000813)	1.89591276
80	Pulmonary fibrosis (HP:0002206)	1.89512531
81	Bilateral microphthalmos (HP:0007633)	1.89455604
82	Abnormal lung lobation (HP:0002101)	1.88131717
83	Abnormality of methionine metabolism (HP:0010901)	1.87878524
84	Small hand (HP:0200055)	1.87538895
85	Cone-rod dystrophy (HP:0000548)	1.87070286
86	Inability to walk (HP:0002540)	1.86921477
87	Increased intramyocellular lipid droplets (HP:0012240)	1.86783992
88	Abnormal pancreas size (HP:0012094)	1.86707116
89	Hepatic necrosis (HP:0002605)	1.86109862
90	Abnormality of serum amino acid levels (HP:0003112)	1.84032350
91	Exertional dyspnea (HP:0002875)	1.83892404
92	Asplenia (HP:0001746)	1.83706882
93	Thyroid-stimulating hormone excess (HP:0002925)	1.80252309
94	Hyperammonemia (HP:0001987)	1.78832911
95	Furrowed tongue (HP:0000221)	1.78585804
96	Hamartoma of the eye (HP:0010568)	1.77671393
97	Abnormality of renal excretion (HP:0011036)	1.77594061
98	Fair hair (HP:0002286)	1.77275591
99	Cerebral edema (HP:0002181)	1.77173382
100	Dyschromatopsia (HP:0007641)	1.76494166

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	3.37377265
2	VRK2	3.37368167
3	NUAK1	3.25312190
4	TLK1	3.14613257
5	TXK	3.10650764
6	KDR	2.97706612
7	PINK1	2.89714740
8	TAOK3	2.79343384
9	WNK3	2.79315414
10	BUB1	2.73909790
11	ZAK	2.68121121
12	FRK	2.65771680
13	GRK1	2.20544787
14	NME1	2.15533722
15	MAP4K1	2.05522499
16	ADRBK2	1.90247617
17	MAP4K2	1.82796687
18	KIT	1.80936944
19	FER	1.62283127
20	WEE1	1.54409356
21	TIE1	1.54218433
22	PHKG2	1.49341780
23	PHKG1	1.49341780
24	MAPKAPK5	1.42016675
25	VRK1	1.34727980
26	PAK6	1.21190264
27	OXSR1	1.20444762
28	MKNK1	1.18185037
29	ERBB3	1.12084655
30	CDK19	1.10790629
31	NEK2	1.06697266
32	MYLK	1.05609029
33	PLK4	1.02637914
34	BMPR1B	1.00747168
35	BCKDK	0.99759107
36	PLK3	0.98310510
37	SIK3	0.97511991
38	MAPK13	0.95785897
39	MAP3K10	0.93189958
40	SYK	0.92190644
41	PLK2	0.91175233
42	ADRBK1	0.90489669
43	MAP3K12	0.87203472
44	ATR	0.86109476
45	TNIK	0.85768675
46	SRPK1	0.81929455
47	INSRR	0.80584265
48	TSSK6	0.78818264
49	CSF1R	0.76769191
50	TNK2	0.76472211
51	TRIM28	0.75140292
52	PIK3CA	0.67081356
53	LYN	0.67064663
54	PRKAA2	0.66837393
55	FES	0.66559981
56	CAMKK1	0.63764142
57	PAK3	0.62136973
58	GRK6	0.62004919
59	CSNK1G3	0.61578414
60	TEC	0.60572780
61	DYRK2	0.59817085
62	EIF2AK2	0.58689735
63	IRAK4	0.58541023
64	CSNK1A1	0.57954469
65	RPS6KA5	0.56725172
66	CCNB1	0.56332026
67	PLK1	0.55471606
68	CDK3	0.55036190
69	STK38L	0.54866505
70	STK3	0.54814020
71	EIF2AK3	0.53625201
72	TAF1	0.51894573
73	CSNK1G1	0.51031691
74	IGF1R	0.50212577
75	BCR	0.48949131
76	PRKD3	0.48806147
77	CDK9	0.48421310
78	PRKCA	0.48389696
79	PTK2B	0.46700452
80	IKBKB	0.46140869
81	PRKCG	0.46113527
82	PRKCE	0.46102988
83	TGFBR1	0.46096315
84	ABL1	0.45878874
85	BRSK2	0.44428600
86	CSNK1G2	0.44157832
87	ERBB4	0.44099899
88	CAMK2A	0.43927880
89	GRK5	0.42649037
90	OBSCN	0.42609446
91	PRKACA	0.40562889
92	MARK1	0.40376142
93	CSNK1A1L	0.40204723
94	ATM	0.39009010
95	PRKD1	0.38338678
96	CSNK2A1	0.38044144
97	ITK	0.37317217
98	LIMK1	0.34301490
99	CDK8	0.33724956
100	PRKACG	0.29620778

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.45846393
2	Proteasome_Homo sapiens_hsa03050	3.21387464
3	Sulfur metabolism_Homo sapiens_hsa00920	2.98355427
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.87452766
5	Allograft rejection_Homo sapiens_hsa05330	2.51523516
6	Phototransduction_Homo sapiens_hsa04744	2.38541131
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.37201369
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.36334852
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.28440104
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.24440498
11	Parkinsons disease_Homo sapiens_hsa05012	2.23220010
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.18758114
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.17816935
14	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.90439731
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.87526967
16	Mismatch repair_Homo sapiens_hsa03430	1.78820713
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.76537394
18	Propanoate metabolism_Homo sapiens_hsa00640	1.72417467
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.69885110
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56379207
21	Base excision repair_Homo sapiens_hsa03410	1.52473375
22	Homologous recombination_Homo sapiens_hsa03440	1.49688028
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48840045
24	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.42482145
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33786137
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.32009170
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31949510
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31552435
29	RNA degradation_Homo sapiens_hsa03018	1.28963449
30	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.28364030
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.27299255
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.26344410
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.25311153
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.24496370
35	Butanoate metabolism_Homo sapiens_hsa00650	1.24180649
36	ABC transporters_Homo sapiens_hsa02010	1.23754253
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.22891238
38	Caffeine metabolism_Homo sapiens_hsa00232	1.20270406
39	Peroxisome_Homo sapiens_hsa04146	1.20259225
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.14374584
41	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.11553128
42	RNA polymerase_Homo sapiens_hsa03020	1.07523935
43	Huntingtons disease_Homo sapiens_hsa05016	1.06599585
44	Alzheimers disease_Homo sapiens_hsa05010	1.06269673
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.05844637
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05549495
47	Nitrogen metabolism_Homo sapiens_hsa00910	1.02583295
48	Rheumatoid arthritis_Homo sapiens_hsa05323	1.01758369
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.00946331
50	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.97540229
51	Viral myocarditis_Homo sapiens_hsa05416	0.93998031
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.87050453
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.86714323
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86705443
55	Protein export_Homo sapiens_hsa03060	0.86062546
56	Leishmaniasis_Homo sapiens_hsa05140	0.85418595
57	DNA replication_Homo sapiens_hsa03030	0.84053890
58	Nicotine addiction_Homo sapiens_hsa05033	0.83695932
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83564287
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81759426
61	Purine metabolism_Homo sapiens_hsa00230	0.81501845
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80761645
63	Retinol metabolism_Homo sapiens_hsa00830	0.78782646
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.78767638
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75613419
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.75076080
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74212362
68	One carbon pool by folate_Homo sapiens_hsa00670	0.70383841
69	Ribosome_Homo sapiens_hsa03010	0.69538008
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68721265
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.67789427
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66684363
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.65368036
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.62634150
75	p53 signaling pathway_Homo sapiens_hsa04115	0.59928536
76	Malaria_Homo sapiens_hsa05144	0.56712093
77	Olfactory transduction_Homo sapiens_hsa04740	0.56417417
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55875685
79	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.52569091
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48608925
81	Non-homologous end-joining_Homo sapiens_hsa03450	0.47872409
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.47846803
83	Metabolic pathways_Homo sapiens_hsa01100	0.44634394
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44522099
85	Taste transduction_Homo sapiens_hsa04742	0.44349028
86	Basal transcription factors_Homo sapiens_hsa03022	0.40302598
87	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40116058
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37271197
89	Fatty acid elongation_Homo sapiens_hsa00062	0.35664934
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35140801
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32096533
92	Sulfur relay system_Homo sapiens_hsa04122	0.31899261
93	Insulin secretion_Homo sapiens_hsa04911	0.31054844
94	Serotonergic synapse_Homo sapiens_hsa04726	0.30226905
95	Herpes simplex infection_Homo sapiens_hsa05168	0.30042369
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.29659117
97	RNA transport_Homo sapiens_hsa03013	0.28173034
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.26887026
99	Circadian rhythm_Homo sapiens_hsa04710	0.25968253
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.24821027

SMARCE1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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