ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	9.60549381
2	cytidine catabolic process (GO:0006216)	9.60549381
3	cytidine deamination (GO:0009972)	9.60549381
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	8.71920739
5	DNA deamination (GO:0045006)	8.38779569
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	8.19684351
7	negative regulation by host of viral transcription (GO:0043922)	6.22108906
8	eosinophil chemotaxis (GO:0048245)	4.87165361
9	positive regulation of interleukin-8 secretion (GO:2000484)	4.78120082
10	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.67249283
11	cytolysis (GO:0019835)	4.54243665
12	eosinophil migration (GO:0072677)	4.40218182
13	positive regulation of T cell apoptotic process (GO:0070234)	4.38301027
14	regulation of lymphocyte chemotaxis (GO:1901623)	4.38259998
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.33835046
16	actin nucleation (GO:0045010)	4.23200483
17	positive T cell selection (GO:0043368)	4.15957716
18	negative regulation of T cell apoptotic process (GO:0070233)	4.15777893
19	positive thymic T cell selection (GO:0045059)	4.08345840
20	regulation of regulatory T cell differentiation (GO:0045589)	4.05387645
21	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.05149486
22	DNA demethylation (GO:0080111)	4.03176781
23	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.00806940
24	negative regulation of viral transcription (GO:0032897)	3.90254837
25	regulation of activation of Janus kinase activity (GO:0010533)	3.89579461
26	positive regulation of tolerance induction (GO:0002645)	3.87554229
27	regulation of chronic inflammatory response (GO:0002676)	3.87310556
28	macrophage chemotaxis (GO:0048246)	3.83968724
29	regulation of T cell chemotaxis (GO:0010819)	3.82775117
30	positive regulation of T cell chemotaxis (GO:0010820)	3.82775117
31	regulation of B cell receptor signaling pathway (GO:0050855)	3.70188765
32	pyrimidine nucleoside catabolic process (GO:0046135)	3.68281047
33	regulation of interleukin-8 secretion (GO:2000482)	3.61097843
34	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.56042170
35	regulation of natural killer cell mediated immunity (GO:0002715)	3.56042170
36	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.55378460
37	positive regulation of calcium-mediated signaling (GO:0050850)	3.50819429
38	negative regulation of viral genome replication (GO:0045071)	3.49218869
39	DNA dealkylation (GO:0035510)	3.48759281
40	modulation by host of symbiont transcription (GO:0052472)	3.47764202
41	modulation by host of viral transcription (GO:0043921)	3.47764202
42	positive regulation of lymphocyte migration (GO:2000403)	3.47125024
43	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.43883467
44	regulation of cellular amino acid metabolic process (GO:0006521)	3.42316207
45	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.40943199
46	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.40094590
47	regulation of T cell tolerance induction (GO:0002664)	3.38869065
48	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	3.34240856
49	positive regulation of lymphocyte apoptotic process (GO:0070230)	3.30435848
50	positive regulation of defense response to virus by host (GO:0002230)	3.24150729
51	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.21707267
52	positive regulation of cell killing (GO:0031343)	3.16183748
53	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.10617298
54	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.08559802
55	negative regulation of ligase activity (GO:0051352)	3.08559802
56	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.07783093
57	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.07409849
58	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.07409849
59	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.07409849
60	T cell costimulation (GO:0031295)	3.06279145
61	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.05334908
62	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.02929492
63	rRNA transcription (GO:0009303)	3.02913760
64	lymphocyte costimulation (GO:0031294)	3.02446209
65	regulation of T cell apoptotic process (GO:0070232)	3.02277619
66	organic cation transport (GO:0015695)	3.00969334
67	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.99426767
68	negative regulation of B cell activation (GO:0050869)	2.99282854
69	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.96498861
70	negative regulation of B cell mediated immunity (GO:0002713)	2.96498861
71	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.96466414
72	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.96466414
73	labyrinthine layer development (GO:0060711)	2.90936766
74	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.90293705
75	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.90293705
76	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.87658245
77	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.86350780
78	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.86336821
79	regulation of calcium-mediated signaling (GO:0050848)	2.85985027
80	ribosomal small subunit assembly (GO:0000028)	2.85637500
81	phagocytosis, recognition (GO:0006910)	2.85155429
82	regulation of interleukin-2 biosynthetic process (GO:0045076)	2.84314051
83	thymic T cell selection (GO:0045061)	2.84286345
84	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.82878798
85	regulation of meiosis I (GO:0060631)	2.82232348
86	proteasome assembly (GO:0043248)	2.81910756
87	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.81733742
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.81733742
89	regulation of tolerance induction (GO:0002643)	2.80932241
90	negative regulation of viral process (GO:0048525)	2.80252227
91	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.79400519
92	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	2.79293160
93	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.78868452
94	cellular response to interleukin-15 (GO:0071350)	2.78301174
95	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.76273423
96	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.72722622
97	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.72499269
98	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.72208454
99	regulation of cell killing (GO:0031341)	2.72047409
100	positive regulation of monocyte chemotaxis (GO:0090026)	2.69710286

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	8.14648690
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.61509047
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	4.05041948
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.27029765
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.93238092
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.90787612
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77114940
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.71480942
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55969733
10	VDR_22108803_ChIP-Seq_LS180_Human	2.45112930
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42936797
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.41923929
13	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.41907116
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30706143
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.28262996
16	MYB_26560356_Chip-Seq_TH2_Human	2.27520676
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.21195429
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.11374579
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.92642693
20	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.90058130
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87510542
22	HTT_18923047_ChIP-ChIP_STHdh_Human	1.83719890
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.83025718
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.79176417
25	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.77214932
26	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.77079305
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.73258155
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.71470111
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.70792967
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.62900059
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.58595523
32	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.58390969
33	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.58122145
34	GATA3_27048872_Chip-Seq_THYMUS_Human	1.55402497
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.53862998
36	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53247668
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46904211
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46628205
39	GATA3_26560356_Chip-Seq_TH2_Human	1.46256512
40	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.43002774
41	EZH2_22144423_ChIP-Seq_EOC_Human	1.39766802
42	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.39163675
43	EWS_26573619_Chip-Seq_HEK293_Human	1.35437826
44	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.32836900
45	CIITA_25753668_ChIP-Seq_RAJI_Human	1.32758810
46	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.30859541
47	ELK1_19687146_ChIP-ChIP_HELA_Human	1.30484859
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29592065
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.25502367
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24001710
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24001710
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23329241
53	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21193076
54	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19386292
55	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.18625328
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17847897
57	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.15749667
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.13426309
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12862657
60	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.12486790
61	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11223740
62	NCOR_22424771_ChIP-Seq_293T_Human	1.10228224
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.09866224
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09866224
65	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.09187923
66	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07067895
67	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.06253467
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06060058
69	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05812102
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05744652
71	FUS_26573619_Chip-Seq_HEK293_Human	1.05469428
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.05060575
73	GATA3_26560356_Chip-Seq_TH1_Human	1.04961064
74	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04675318
75	MYB_26560356_Chip-Seq_TH1_Human	1.04487818
76	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.03335366
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02591200
78	PHF8_20622853_ChIP-Seq_HELA_Human	1.00726401
79	AR_20517297_ChIP-Seq_VCAP_Human	0.99378403
80	TTF2_22483619_ChIP-Seq_HELA_Human	0.99090615
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99049440
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98920969
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98124806
84	NANOG_19829295_ChIP-Seq_ESCs_Human	0.96319614
85	SOX2_19829295_ChIP-Seq_ESCs_Human	0.96319614
86	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95069413
87	BCAT_22108803_ChIP-Seq_LS180_Human	0.94875521
88	TAF15_26573619_Chip-Seq_HEK293_Human	0.94374135
89	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92449448
90	RBPJ_21746931_ChIP-Seq_IB4_Human	0.92354741
91	RUNX_20019798_ChIP-Seq_JUKART_Human	0.92220933
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92068035
93	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89969425
94	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87230281
95	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.87013941
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.86435132
97	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.85701023
98	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.84383038
99	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.83498545
100	ER_23166858_ChIP-Seq_MCF-7_Human	0.83309383

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.44580303
2	MP0002138_abnormal_hepatobiliary_system	4.44243894
3	MP0005075_abnormal_melanosome_morpholog	3.63737504
4	MP0004147_increased_porphyrin_level	3.35744498
5	MP0001835_abnormal_antigen_presentation	3.28721509
6	MP0004381_abnormal_hair_follicle	2.77861199
7	MP0003786_premature_aging	2.77553941
8	MP0001873_stomach_inflammation	2.71877258
9	MP0002132_abnormal_respiratory_system	2.50679070
10	MP0009785_altered_susceptibility_to	2.45327633
11	MP0006082_CNS_inflammation	2.42770317
12	MP0002166_altered_tumor_susceptibility	2.41750942
13	MP0003763_abnormal_thymus_physiology	2.22070351
14	MP0002006_tumorigenesis	2.20014990
15	MP0001188_hyperpigmentation	2.12932967
16	MP0000372_irregular_coat_pigmentation	2.04364229
17	MP0005084_abnormal_gallbladder_morpholo	1.97525105
18	MP0003866_abnormal_defecation	1.97519008
19	MP0002277_abnormal_respiratory_mucosa	1.91146138
20	MP0003806_abnormal_nucleotide_metabolis	1.81909655
21	MP0001790_abnormal_immune_system	1.76859063
22	MP0005387_immune_system_phenotype	1.76859063
23	MP0009333_abnormal_splenocyte_physiolog	1.76241023
24	MP0005000_abnormal_immune_tolerance	1.75951772
25	MP0001800_abnormal_humoral_immune	1.70284420
26	MP0001727_abnormal_embryo_implantation	1.69242713
27	MP0002420_abnormal_adaptive_immunity	1.68850278
28	MP0001819_abnormal_immune_cell	1.62546829
29	MP0002163_abnormal_gland_morphology	1.62539801
30	MP0001853_heart_inflammation	1.60856762
31	MP0001661_extended_life_span	1.59636919
32	MP0002398_abnormal_bone_marrow	1.57141799
33	MP0005310_abnormal_salivary_gland	1.56710581
34	MP0000703_abnormal_thymus_morphology	1.56116989
35	MP0002723_abnormal_immune_serum	1.55580896
36	MP0005025_abnormal_response_to	1.52942170
37	MP0000716_abnormal_immune_system	1.51769564
38	MP0003567_abnormal_fetal_cardiomyocyte	1.51166855
39	MP0002405_respiratory_system_inflammati	1.47875232
40	MP0002638_abnormal_pupillary_reflex	1.47479642
41	MP0000013_abnormal_adipose_tissue	1.46937393
42	MP0003283_abnormal_digestive_organ	1.44436263
43	MP0002722_abnormal_immune_system	1.40226917
44	MP0006276_abnormal_autonomic_nervous	1.39290046
45	MP0002148_abnormal_hypersensitivity_rea	1.36571132
46	MP0003448_altered_tumor_morphology	1.32169918
47	MP0000689_abnormal_spleen_morphology	1.30662752
48	MP0005645_abnormal_hypothalamus_physiol	1.29830621
49	MP0008007_abnormal_cellular_replicative	1.28503281
50	MP0000685_abnormal_immune_system	1.25866674
51	MP0008875_abnormal_xenobiotic_pharmacok	1.24440762
52	MP0006292_abnormal_olfactory_placode	1.19227522
53	MP0008995_early_reproductive_senescence	1.16790829
54	MP0002429_abnormal_blood_cell	1.16340757
55	MP0005377_hearing/vestibular/ear_phenot	1.15992748
56	MP0003878_abnormal_ear_physiology	1.15992748
57	MP0003195_calcinosis	1.13706594
58	MP0002452_abnormal_antigen_presenting	1.11962935
59	MP0004858_abnormal_nervous_system	1.11900658
60	MP0002653_abnormal_ependyma_morphology	1.09172428
61	MP0001984_abnormal_olfaction	1.08854544
62	MP0004947_skin_inflammation	1.08505361
63	MP0001542_abnormal_bone_strength	1.02548864
64	MP0010155_abnormal_intestine_physiology	1.01546356
65	MP0000647_abnormal_sebaceous_gland	1.01003111
66	MP0008058_abnormal_DNA_repair	1.00795021
67	MP0003646_muscle_fatigue	1.00094585
68	MP0004484_altered_response_of	0.97088045
69	MP0005083_abnormal_biliary_tract	0.94715397
70	MP0006035_abnormal_mitochondrial_morpho	0.93393463
71	MP0002933_joint_inflammation	0.93267289
72	MP0002876_abnormal_thyroid_physiology	0.90943997
73	MP0004145_abnormal_muscle_electrophysio	0.88555647
74	MP0004134_abnormal_chest_morphology	0.88252780
75	MP0005646_abnormal_pituitary_gland	0.87785852
76	MP0004142_abnormal_muscle_tone	0.84529886
77	MP0008770_decreased_survivor_rate	0.83851420
78	MP0003252_abnormal_bile_duct	0.83005337
79	MP0003045_fibrosis	0.82556392
80	MP0002735_abnormal_chemical_nociception	0.78941632
81	MP0005423_abnormal_somatic_nervous	0.76870670
82	MP0001845_abnormal_inflammatory_respons	0.75577261
83	MP0001502_abnormal_circadian_rhythm	0.75319142
84	MP0005167_abnormal_blood-brain_barrier	0.73999045
85	MP0001905_abnormal_dopamine_level	0.73819869
86	MP0002160_abnormal_reproductive_system	0.73247655
87	MP0005551_abnormal_eye_electrophysiolog	0.72972081
88	MP0005379_endocrine/exocrine_gland_phen	0.72737272
89	MP0002234_abnormal_pharynx_morphology	0.71505822
90	MP0006072_abnormal_retinal_apoptosis	0.71305063
91	MP0008873_increased_physiological_sensi	0.70428414
92	MP0000631_abnormal_neuroendocrine_gland	0.68086204
93	MP0005360_urolithiasis	0.67036028
94	MP0002751_abnormal_autonomic_nervous	0.64369034
95	MP0002733_abnormal_thermal_nociception	0.62796974
96	MP0002928_abnormal_bile_duct	0.61001282
97	MP0005330_cardiomyopathy	0.59925234
98	MP0005253_abnormal_eye_physiology	0.57500096
99	MP0002019_abnormal_tumor_incidence	0.57468804
100	MP0003111_abnormal_nucleus_morphology	0.57431005

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Elevated erythrocyte sedimentation rate (HP:0003565)	5.85150219
2	3-Methylglutaconic aciduria (HP:0003535)	4.59745688
3	T lymphocytopenia (HP:0005403)	4.21209368
4	Abnormality of T cell number (HP:0011839)	4.16158217
5	Autoimmune hemolytic anemia (HP:0001890)	4.02441727
6	Aplastic anemia (HP:0001915)	3.99522457
7	Pancreatic cysts (HP:0001737)	3.68502905
8	Hypoproteinemia (HP:0003075)	3.64322342
9	Increased hepatocellular lipid droplets (HP:0006565)	3.51889905
10	Large eyes (HP:0001090)	3.40123255
11	Increased IgM level (HP:0003496)	3.35800969
12	Encephalitis (HP:0002383)	3.29820596
13	Increased intramyocellular lipid droplets (HP:0012240)	3.28754670
14	True hermaphroditism (HP:0010459)	3.21352942
15	Mitochondrial inheritance (HP:0001427)	3.15269746
16	Type I transferrin isoform profile (HP:0003642)	3.14757956
17	Lipid accumulation in hepatocytes (HP:0006561)	3.14048152
18	Cerebellar dysplasia (HP:0007033)	2.97789298
19	Abnormality of the prostate (HP:0008775)	2.96399499
20	Congenital stationary night blindness (HP:0007642)	2.95485544
21	Acute necrotizing encephalopathy (HP:0006965)	2.84836764
22	Increased CSF lactate (HP:0002490)	2.82402134
23	Abnormality of T cells (HP:0002843)	2.81907937
24	Hepatocellular necrosis (HP:0001404)	2.69718845
25	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.69684690
26	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.69684690
27	Pancreatic fibrosis (HP:0100732)	2.67741861
28	Renal Fanconi syndrome (HP:0001994)	2.65984017
29	Chronic otitis media (HP:0000389)	2.65942299
30	Increased muscle lipid content (HP:0009058)	2.65082989
31	Abnormality of alanine metabolism (HP:0010916)	2.54419172
32	Hyperalaninemia (HP:0003348)	2.54419172
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54419172
34	Abnormal mitochondria in muscle tissue (HP:0008316)	2.52677765
35	IgG deficiency (HP:0004315)	2.52296806
36	Abnormality of eosinophils (HP:0001879)	2.51520220
37	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.50052720
38	Eosinophilia (HP:0001880)	2.47362007
39	Hypergammaglobulinemia (HP:0010702)	2.47361016
40	Reduced subcutaneous adipose tissue (HP:0003758)	2.45724204
41	Meningitis (HP:0001287)	2.38615397
42	Hepatic necrosis (HP:0002605)	2.37877706
43	Increased serum lactate (HP:0002151)	2.35639650
44	Abnormal protein glycosylation (HP:0012346)	2.34764117
45	Abnormal glycosylation (HP:0012345)	2.34764117
46	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.34764117
47	Abnormal protein N-linked glycosylation (HP:0012347)	2.34764117
48	Optic disc pallor (HP:0000543)	2.29291086
49	Hemiplegia (HP:0002301)	2.26300047
50	Severe combined immunodeficiency (HP:0004430)	2.25656245
51	Exertional dyspnea (HP:0002875)	2.24236105
52	Autoimmune thrombocytopenia (HP:0001973)	2.23636257
53	Chronic sinusitis (HP:0011109)	2.23413106
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.21189331
55	Renal cortical cysts (HP:0000803)	2.20938412
56	Abnormality of urine glucose concentration (HP:0011016)	2.20522002
57	Glycosuria (HP:0003076)	2.20522002
58	Clubbing of toes (HP:0100760)	2.16766242
59	Chest pain (HP:0100749)	2.16098083
60	Progressive macrocephaly (HP:0004481)	2.13621854
61	Abnormality of the pleura (HP:0002103)	2.13548198
62	Nephronophthisis (HP:0000090)	2.12968422
63	Acute encephalopathy (HP:0006846)	2.09042082
64	Molar tooth sign on MRI (HP:0002419)	2.08282518
65	Abnormality of midbrain morphology (HP:0002418)	2.08282518
66	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04557142
67	Myositis (HP:0100614)	2.02567775
68	Aplasia/hypoplasia of the uterus (HP:0008684)	2.01548549
69	Generalized aminoaciduria (HP:0002909)	2.01116820
70	Recurrent bronchitis (HP:0002837)	2.01116077
71	Lymphoma (HP:0002665)	2.00053592
72	Retrobulbar optic neuritis (HP:0100654)	1.97134937
73	Optic neuritis (HP:0100653)	1.97134937
74	Neuroendocrine neoplasm (HP:0100634)	1.96009138
75	Microretrognathia (HP:0000308)	1.94552650
76	Prostate neoplasm (HP:0100787)	1.93101377
77	Gait imbalance (HP:0002141)	1.92552485
78	Granulocytopenia (HP:0001913)	1.91835372
79	Pancytopenia (HP:0001876)	1.91721888
80	Abnormality of renal resorption (HP:0011038)	1.91018610
81	Congenital primary aphakia (HP:0007707)	1.90883786
82	Failure to thrive in infancy (HP:0001531)	1.88564695
83	Attenuation of retinal blood vessels (HP:0007843)	1.87988690
84	Hemoptysis (HP:0002105)	1.84579984
85	Gangrene (HP:0100758)	1.84434006
86	Type II lissencephaly (HP:0007260)	1.83736908
87	Cystic liver disease (HP:0006706)	1.83674970
88	Abnormal rod and cone electroretinograms (HP:0008323)	1.83456627
89	Ureteral stenosis (HP:0000071)	1.83372685
90	Medial flaring of the eyebrow (HP:0010747)	1.82998770
91	Microcytic anemia (HP:0001935)	1.82610048
92	Abnormality of male internal genitalia (HP:0000022)	1.82034991
93	Lactic acidosis (HP:0003128)	1.80762825
94	Cerebral edema (HP:0002181)	1.80363608
95	Erythema (HP:0010783)	1.80204104
96	Combined immunodeficiency (HP:0005387)	1.79985175
97	Sclerocornea (HP:0000647)	1.79899475
98	Chronic obstructive pulmonary disease (HP:0006510)	1.76095807
99	Obstructive lung disease (HP:0006536)	1.76095807
100	Nephrogenic diabetes insipidus (HP:0009806)	1.75619912

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	5.84812834
2	TXK	5.76031053
3	KDR	4.79241847
4	TAOK3	3.56020679
5	PBK	3.33393183
6	BUB1	2.81385880
7	BMPR1B	2.30066595
8	TLK1	2.23294364
9	SCYL2	2.20855343
10	TESK2	2.20690807
11	VRK1	2.13814491
12	BCKDK	2.10162873
13	ITK	2.07482822
14	STK16	2.00766768
15	BRSK2	1.74192894
16	FRK	1.66433291
17	ADRBK2	1.60359662
18	MST4	1.55665055
19	WNK4	1.42443767
20	MARK3	1.39513610
21	NUAK1	1.34667800
22	MAP4K2	1.33549197
23	PRKCQ	1.29569389
24	MAP3K5	1.27417772
25	VRK2	1.25935930
26	GRK1	1.22956207
27	PLK4	1.19158772
28	MAP4K1	1.09546875
29	IKBKB	1.09452177
30	MAP2K6	1.08324070
31	MATK	1.03545444
32	WEE1	0.99347301
33	LCK	0.95451338
34	CDK12	0.91238698
35	MAP3K12	0.87596166
36	TEC	0.86585258
37	IRAK1	0.85954319
38	GRK7	0.82808820
39	CHUK	0.82145241
40	ACVR1B	0.75129975
41	PRKCH	0.73574795
42	SYK	0.73568359
43	BMPR2	0.73372668
44	DAPK1	0.73367125
45	PASK	0.71149119
46	PIM1	0.69021397
47	MYLK	0.68288360
48	CDK19	0.66695085
49	AKT3	0.66151322
50	MAPKAPK3	0.65973022
51	TAF1	0.65501009
52	PRKD3	0.61310404
53	MAPK13	0.60544050
54	SRPK1	0.58659031
55	MAP2K7	0.57754992
56	NTRK1	0.56568201
57	ZAP70	0.54803237
58	BTK	0.53516860
59	TIE1	0.50594440
60	PLK3	0.50220258
61	ATR	0.49330620
62	RPS6KA5	0.48500283
63	PIK3CG	0.48333892
64	JAK3	0.48251473
65	LYN	0.48089889
66	PKN1	0.47590329
67	INSRR	0.46611513
68	WNK3	0.46090036
69	PIK3CA	0.45549960
70	AURKA	0.45258732
71	DYRK1A	0.45211061
72	GRK5	0.44130730
73	LIMK1	0.42639247
74	PLK2	0.42399629
75	TTK	0.42039522
76	CHEK2	0.40559415
77	OXSR1	0.39962411
78	TNK2	0.38897493
79	ADRBK1	0.38565334
80	DYRK1B	0.35151726
81	MUSK	0.34937651
82	DYRK2	0.34487533
83	ERBB2	0.34026983
84	INSR	0.32440408
85	BRD4	0.32186976
86	CSNK1G3	0.32185068
87	PAK1	0.31628289
88	PINK1	0.31361898
89	PLK1	0.30765451
90	CDK9	0.30511295
91	BRSK1	0.29104678
92	CAMK2A	0.26743210
93	ABL2	0.26163976
94	OBSCN	0.25475755
95	CCNB1	0.25356309
96	FYN	0.23304268
97	PRKACA	0.22281925
98	TRIM28	0.22218911
99	CSK	0.21633374
100	TYRO3	0.21482447

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.93773602
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.43031495
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.36663254
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.14049005
5	Allograft rejection_Homo sapiens_hsa05330	2.82572697
6	Antigen processing and presentation_Homo sapiens_hsa04612	2.67708492
7	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.63758418
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.63324768
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.40735050
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.21364545
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.18739463
12	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.12963875
13	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.03149198
14	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.02207482
15	DNA replication_Homo sapiens_hsa03030	2.00930350
16	RNA polymerase_Homo sapiens_hsa03020	1.93916943
17	Parkinsons disease_Homo sapiens_hsa05012	1.81215473
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.76915015
19	Ribosome_Homo sapiens_hsa03010	1.69819179
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61432811
21	Protein export_Homo sapiens_hsa03060	1.57872337
22	Alcoholism_Homo sapiens_hsa05034	1.55002990
23	Salmonella infection_Homo sapiens_hsa05132	1.45097366
24	Homologous recombination_Homo sapiens_hsa03440	1.41408794
25	Butanoate metabolism_Homo sapiens_hsa00650	1.28083428
26	Propanoate metabolism_Homo sapiens_hsa00640	1.24094731
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19241425
28	Measles_Homo sapiens_hsa05162	1.15782173
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.15069779
30	Peroxisome_Homo sapiens_hsa04146	1.11480890
31	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.06147800
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.05806797
33	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.05618774
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.05255470
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05151631
36	RNA degradation_Homo sapiens_hsa03018	1.04792964
37	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04570256
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.02716565
39	Alzheimers disease_Homo sapiens_hsa05010	0.98051439
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94622337
41	Huntingtons disease_Homo sapiens_hsa05016	0.94132921
42	Spliceosome_Homo sapiens_hsa03040	0.92997573
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.92925285
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92501831
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.91562860
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.91044824
47	Nucleotide excision repair_Homo sapiens_hsa03420	0.88614159
48	Fatty acid elongation_Homo sapiens_hsa00062	0.88075170
49	Asthma_Homo sapiens_hsa05310	0.85846587
50	Shigellosis_Homo sapiens_hsa05131	0.82597371
51	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.82318078
52	Retinol metabolism_Homo sapiens_hsa00830	0.81715191
53	Phototransduction_Homo sapiens_hsa04744	0.80249109
54	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.79326731
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79244775
56	Basal transcription factors_Homo sapiens_hsa03022	0.78236110
57	Mismatch repair_Homo sapiens_hsa03430	0.72234480
58	Viral carcinogenesis_Homo sapiens_hsa05203	0.70999673
59	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.69790353
60	ABC transporters_Homo sapiens_hsa02010	0.67411833
61	Malaria_Homo sapiens_hsa05144	0.67126258
62	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.62359643
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59881406
64	Olfactory transduction_Homo sapiens_hsa04740	0.59276680
65	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59246345
66	Purine metabolism_Homo sapiens_hsa00230	0.57458058
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.56785980
68	p53 signaling pathway_Homo sapiens_hsa04115	0.55209199
69	Viral myocarditis_Homo sapiens_hsa05416	0.55172905
70	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.52819859
71	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50420465
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.49543000
73	One carbon pool by folate_Homo sapiens_hsa00670	0.49372865
74	Herpes simplex infection_Homo sapiens_hsa05168	0.47815222
75	Caffeine metabolism_Homo sapiens_hsa00232	0.47297747
76	Sulfur relay system_Homo sapiens_hsa04122	0.47043205
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46845201
78	Non-homologous end-joining_Homo sapiens_hsa03450	0.45873600
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45802058
80	African trypanosomiasis_Homo sapiens_hsa05143	0.45288777
81	Taste transduction_Homo sapiens_hsa04742	0.45241110
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.44767311
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.44297351
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43833277
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.43411822
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43220672
87	RNA transport_Homo sapiens_hsa03013	0.40019558
88	Legionellosis_Homo sapiens_hsa05134	0.39115337
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37934768
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.36556619
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34102477
92	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33825411
93	HTLV-I infection_Homo sapiens_hsa05166	0.31791701
94	Nicotine addiction_Homo sapiens_hsa05033	0.28583413
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25425610
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.23737194
97	Chemokine signaling pathway_Homo sapiens_hsa04062	0.23058894
98	Apoptosis_Homo sapiens_hsa04210	0.22712372
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.22604704
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.21225647

SMARCE1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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