ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.13524394
2	cytidine deamination (GO:0009972)	6.36551315
3	cytidine metabolic process (GO:0046087)	6.36551315
4	cytidine catabolic process (GO:0006216)	6.36551315
5	sequestering of actin monomers (GO:0042989)	6.08237525
6	DNA deamination (GO:0045006)	5.73803820
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.62829771
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.79547223
9	protein neddylation (GO:0045116)	4.64590554
10	protein-cofactor linkage (GO:0018065)	4.59679690
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.59225668
12	ATP synthesis coupled proton transport (GO:0015986)	4.59225668
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.58811983
14	neuronal action potential propagation (GO:0019227)	4.41562140
15	respiratory electron transport chain (GO:0022904)	4.14213222
16	electron transport chain (GO:0022900)	4.09459588
17	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.82917276
18	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.75413666
19	epithelial cilium movement (GO:0003351)	3.70183388
20	DNA demethylation (GO:0080111)	3.61896335
21	negative regulation by host of viral transcription (GO:0043922)	3.60566492
22	regulation of chronic inflammatory response (GO:0002676)	3.50303999
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.48729754
24	positive regulation of interleukin-8 secretion (GO:2000484)	3.48575042
25	protein complex biogenesis (GO:0070271)	3.42629960
26	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.40832692
27	DNA double-strand break processing (GO:0000729)	3.33918409
28	negative regulation of T cell apoptotic process (GO:0070233)	3.32053121
29	cilium movement (GO:0003341)	3.26532189
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.19379031
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.19379031
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.18925995
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.18925995
34	NADH dehydrogenase complex assembly (GO:0010257)	3.18925995
35	regulation of natural killer cell mediated immunity (GO:0002715)	3.08272963
36	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.08272963
37	platelet dense granule organization (GO:0060155)	3.07475601
38	macrophage chemotaxis (GO:0048246)	3.05777546
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04607392
40	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.02937921
41	cytolysis (GO:0019835)	3.01815447
42	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.01161970
43	regulation of cilium movement (GO:0003352)	2.99545264
44	mismatch repair (GO:0006298)	2.98453550
45	negative regulation of telomere maintenance (GO:0032205)	2.96151535
46	axoneme assembly (GO:0035082)	2.94126399
47	eosinophil chemotaxis (GO:0048245)	2.91671792
48	regulation of activation of Janus kinase activity (GO:0010533)	2.91172658
49	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91073218
50	DNA dealkylation (GO:0035510)	2.85933394
51	intraciliary transport (GO:0042073)	2.85474198
52	nonmotile primary cilium assembly (GO:0035058)	2.85271519
53	regulation of regulatory T cell differentiation (GO:0045589)	2.84998006
54	regulation of cellular amino acid metabolic process (GO:0006521)	2.82938026
55	hydrogen ion transmembrane transport (GO:1902600)	2.82776899
56	GPI anchor metabolic process (GO:0006505)	2.82187370
57	purine deoxyribonucleotide catabolic process (GO:0009155)	2.80627740
58	regulation of mitotic spindle checkpoint (GO:1903504)	2.80196493
59	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.80196493
60	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.79334011
61	fucose catabolic process (GO:0019317)	2.76708168
62	L-fucose metabolic process (GO:0042354)	2.76708168
63	L-fucose catabolic process (GO:0042355)	2.76708168
64	GPI anchor biosynthetic process (GO:0006506)	2.76195877
65	axonemal dynein complex assembly (GO:0070286)	2.75057169
66	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.74947790
67	negative regulation of ligase activity (GO:0051352)	2.74947790
68	base-excision repair, AP site formation (GO:0006285)	2.71661338
69	proton transport (GO:0015992)	2.70778885
70	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.68128093
71	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.67123003
72	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.67123003
73	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.67123003
74	positive T cell selection (GO:0043368)	2.66151187
75	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.65935878
76	protein K6-linked ubiquitination (GO:0085020)	2.64526013
77	regulation of interleukin-8 secretion (GO:2000482)	2.62944679
78	eosinophil migration (GO:0072677)	2.62742032
79	cellular response to interferon-beta (GO:0035458)	2.62619372
80	hydrogen transport (GO:0006818)	2.62253236
81	regulation of DNA endoreduplication (GO:0032875)	2.61563612
82	prenylation (GO:0097354)	2.61503862
83	protein prenylation (GO:0018342)	2.61503862
84	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.60323810
85	mast cell activation involved in immune response (GO:0002279)	2.58188457
86	mast cell degranulation (GO:0043303)	2.58188457
87	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.58041059
88	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.58041059
89	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.57785406
90	telomere maintenance via semi-conservative replication (GO:0032201)	2.56132825
91	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.53060731
92	positive regulation of protein homodimerization activity (GO:0090073)	2.52901168
93	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.52455428
94	termination of RNA polymerase III transcription (GO:0006386)	2.52455428
95	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.51692020
96	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.51692020
97	protein localization to cilium (GO:0061512)	2.51598158
98	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.50518247
99	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.48577914
100	telomere maintenance via telomere lengthening (GO:0010833)	2.47987193

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.38553591
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.50368110
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.37877384
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.27129501
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.21164283
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.83471794
7	VDR_22108803_ChIP-Seq_LS180_Human	2.66022896
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.60168122
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.58570415
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.27925936
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.14610485
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.14359271
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.11401489
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02039477
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.00250370
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.98612523
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.96208066
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.92139663
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.86317992
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.85387181
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84896594
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.79689798
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78469126
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.76479467
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72146409
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66128032
27	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.65545698
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63330421
29	P300_19829295_ChIP-Seq_ESCs_Human	1.61613124
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.57690734
31	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.57105474
32	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.55994346
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55202623
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52651571
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.51439821
36	EWS_26573619_Chip-Seq_HEK293_Human	1.49605146
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.47631523
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.43605641
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43044059
40	FUS_26573619_Chip-Seq_HEK293_Human	1.42222795
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.39734443
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29640330
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28820808
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28820808
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24707884
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24474951
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.24367669
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21531470
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.21531470
50	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.19499058
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18391981
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14560231
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13978869
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13978869
55	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.13947419
56	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.13025651
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12484261
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11708319
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10592945
60	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.10320332
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.10066514
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08168907
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08098147
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06058132
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05915650
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04908794
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.04645757
68	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.04300216
69	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.04105072
70	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03006473
71	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.02454591
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.02380369
73	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.01631967
74	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00856410
75	AR_20517297_ChIP-Seq_VCAP_Human	1.00481711
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00326473
77	NCOR_22424771_ChIP-Seq_293T_Human	1.00276578
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98158474
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96181900
80	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95788104
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94765595
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93489688
83	E2F7_22180533_ChIP-Seq_HELA_Human	0.93425899
84	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92048661
85	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91432216
86	GABP_19822575_ChIP-Seq_HepG2_Human	0.90496072
87	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.89955592
88	AR_25329375_ChIP-Seq_VCAP_Human	0.88957719
89	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86553539
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.86057257
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.84581917
92	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.84227065
93	PHF8_20622853_ChIP-Seq_HELA_Human	0.84105736
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.84067225
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.83462868
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.82818936
97	GATA3_26560356_Chip-Seq_TH2_Human	0.82481596
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.82276341
99	STAT3_23295773_ChIP-Seq_U87_Human	0.81238533
100	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.80732100

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.54725303
2	MP0005377_hearing/vestibular/ear_phenot	3.40921714
3	MP0003878_abnormal_ear_physiology	3.40921714
4	MP0002736_abnormal_nociception_after	2.95267761
5	MP0002102_abnormal_ear_morphology	2.64032254
6	MP0006072_abnormal_retinal_apoptosis	2.52499829
7	MP0008877_abnormal_DNA_methylation	2.45112884
8	MP0003786_premature_aging	2.44735496
9	MP0001968_abnormal_touch/_nociception	2.37020267
10	MP0004043_abnormal_pH_regulation	2.33323104
11	MP0005253_abnormal_eye_physiology	1.97462030
12	MP0001984_abnormal_olfaction	1.96990498
13	MP0005551_abnormal_eye_electrophysiolog	1.96181357
14	MP0002653_abnormal_ependyma_morphology	1.94730221
15	MP0004147_increased_porphyrin_level	1.94245776
16	MP0002277_abnormal_respiratory_mucosa	1.91705863
17	MP0006276_abnormal_autonomic_nervous	1.75391936
18	MP0004142_abnormal_muscle_tone	1.74789878
19	MP0008058_abnormal_DNA_repair	1.73006467
20	MP0000372_irregular_coat_pigmentation	1.72852775
21	MP0006292_abnormal_olfactory_placode	1.72361688
22	MP0009745_abnormal_behavioral_response	1.59135211
23	MP0008789_abnormal_olfactory_epithelium	1.58972004
24	MP0004145_abnormal_muscle_electrophysio	1.58308006
25	MP0002163_abnormal_gland_morphology	1.52469897
26	MP0008995_early_reproductive_senescence	1.51570508
27	MP0002272_abnormal_nervous_system	1.48828870
28	MP0006035_abnormal_mitochondrial_morpho	1.46180308
29	MP0003195_calcinosis	1.43681715
30	MP0003011_delayed_dark_adaptation	1.42548062
31	MP0001486_abnormal_startle_reflex	1.32561305
32	MP0002095_abnormal_skin_pigmentation	1.32177173
33	MP0003938_abnormal_ear_development	1.29846785
34	MP0003137_abnormal_impulse_conducting	1.28296444
35	MP0003136_yellow_coat_color	1.23616505
36	MP0003787_abnormal_imprinting	1.21446951
37	MP0001905_abnormal_dopamine_level	1.20954833
38	MP0005394_taste/olfaction_phenotype	1.16360960
39	MP0005499_abnormal_olfactory_system	1.16360960
40	MP0001485_abnormal_pinna_reflex	1.15174564
41	MP0005646_abnormal_pituitary_gland	1.14869630
42	MP0006036_abnormal_mitochondrial_physio	1.13110915
43	MP0008875_abnormal_xenobiotic_pharmacok	1.11279830
44	MP0009785_altered_susceptibility_to	1.11162998
45	MP0001661_extended_life_span	1.10871215
46	MP0002638_abnormal_pupillary_reflex	1.08485922
47	MP0001501_abnormal_sleep_pattern	1.05602314
48	MP0001919_abnormal_reproductive_system	1.04756075
49	MP0001188_hyperpigmentation	1.00827000
50	MP0003693_abnormal_embryo_hatching	1.00215433
51	MP0005075_abnormal_melanosome_morpholog	0.99644575
52	MP0005410_abnormal_fertilization	0.96839822
53	MP0001502_abnormal_circadian_rhythm	0.94864578
54	MP0005389_reproductive_system_phenotype	0.93775385
55	MP0002557_abnormal_social/conspecific_i	0.93071949
56	MP0002234_abnormal_pharynx_morphology	0.92706719
57	MP0005195_abnormal_posterior_eye	0.92018736
58	MP0002064_seizures	0.91699010
59	MP0003121_genomic_imprinting	0.91417444
60	MP0001119_abnormal_female_reproductive	0.91332696
61	MP0000049_abnormal_middle_ear	0.89746376
62	MP0001293_anophthalmia	0.87023783
63	MP0001324_abnormal_eye_pigmentation	0.86925787
64	MP0003880_abnormal_central_pattern	0.84580536
65	MP0002876_abnormal_thyroid_physiology	0.84470515
66	MP0003718_maternal_effect	0.84050554
67	MP0002909_abnormal_adrenal_gland	0.83768988
68	MP0002138_abnormal_hepatobiliary_system	0.83390430
69	MP0002006_tumorigenesis	0.82946269
70	MP0000026_abnormal_inner_ear	0.82924520
71	MP0005379_endocrine/exocrine_gland_phen	0.82847250
72	MP0003763_abnormal_thymus_physiology	0.82810328
73	MP0002752_abnormal_somatic_nervous	0.82277653
74	MP0001963_abnormal_hearing_physiology	0.82003696
75	MP0001835_abnormal_antigen_presentation	0.81425944
76	MP0003937_abnormal_limbs/digits/tail_de	0.80836435
77	MP0003119_abnormal_digestive_system	0.80779643
78	MP0000631_abnormal_neuroendocrine_gland	0.80522300
79	MP0003635_abnormal_synaptic_transmissio	0.80156613
80	MP0002233_abnormal_nose_morphology	0.79223140
81	MP0008873_increased_physiological_sensi	0.79014488
82	MP0004134_abnormal_chest_morphology	0.78843404
83	MP0002067_abnormal_sensory_capabilities	0.77479913
84	MP0002572_abnormal_emotion/affect_behav	0.76508475
85	MP0008872_abnormal_physiological_respon	0.76224918
86	MP0003567_abnormal_fetal_cardiomyocyte	0.76149608
87	MP0005391_vision/eye_phenotype	0.76090756
88	MP0001800_abnormal_humoral_immune	0.74988258
89	MP0000703_abnormal_thymus_morphology	0.74370006
90	MP0004133_heterotaxia	0.73823110
91	MP0001970_abnormal_pain_threshold	0.72462062
92	MP0004019_abnormal_vitamin_homeostasis	0.72340108
93	MP0003122_maternal_imprinting	0.72142328
94	MP0010094_abnormal_chromosome_stability	0.71250691
95	MP0009333_abnormal_splenocyte_physiolog	0.71248090
96	MP0002723_abnormal_immune_serum	0.71146508
97	MP0002160_abnormal_reproductive_system	0.70943373
98	MP0002063_abnormal_learning/memory/cond	0.70890228
99	MP0000685_abnormal_immune_system	0.70409876
100	MP0001790_abnormal_immune_system	0.69177782

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.45904858
2	Nephronophthisis (HP:0000090)	4.31631966
3	Pancreatic cysts (HP:0001737)	4.19205429
4	Pancreatic fibrosis (HP:0100732)	3.98509664
5	Molar tooth sign on MRI (HP:0002419)	3.95889640
6	Abnormality of midbrain morphology (HP:0002418)	3.95889640
7	Increased hepatocellular lipid droplets (HP:0006565)	3.91118281
8	Lipid accumulation in hepatocytes (HP:0006561)	3.88729411
9	3-Methylglutaconic aciduria (HP:0003535)	3.87025356
10	Focal motor seizures (HP:0011153)	3.83329456
11	Mitochondrial inheritance (HP:0001427)	3.78789271
12	Acute necrotizing encephalopathy (HP:0006965)	3.48837588
13	Abnormality of the renal medulla (HP:0100957)	3.47247476
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.17628933
15	Abnormality of the renal cortex (HP:0011035)	3.17592507
16	Increased CSF lactate (HP:0002490)	3.16599186
17	Hepatocellular necrosis (HP:0001404)	3.06258049
18	Hypoproteinemia (HP:0003075)	3.03670476
19	Acute encephalopathy (HP:0006846)	2.97429794
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.95719489
21	Renal Fanconi syndrome (HP:0001994)	2.92484191
22	Increased intramyocellular lipid droplets (HP:0012240)	2.91063808
23	Progressive macrocephaly (HP:0004481)	2.88821939
24	Colon cancer (HP:0003003)	2.86989945
25	Renal cortical cysts (HP:0000803)	2.85567222
26	Hepatic necrosis (HP:0002605)	2.83740838
27	Abnormality of macular pigmentation (HP:0008002)	2.80358799
28	IgG deficiency (HP:0004315)	2.77238418
29	Hemiplegia (HP:0002301)	2.72304601
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.69756504
31	Medial flaring of the eyebrow (HP:0010747)	2.67400508
32	Abnormal ciliary motility (HP:0012262)	2.65970624
33	Sclerocornea (HP:0000647)	2.61783579
34	Severe combined immunodeficiency (HP:0004430)	2.59228645
35	Polydipsia (HP:0001959)	2.58338805
36	Abnormal drinking behavior (HP:0030082)	2.58338805
37	Attenuation of retinal blood vessels (HP:0007843)	2.58201045
38	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.57702232
39	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.57702232
40	Panhypogammaglobulinemia (HP:0003139)	2.57355752
41	Dyschromatopsia (HP:0007641)	2.55638869
42	Increased muscle lipid content (HP:0009058)	2.52917530
43	Exertional dyspnea (HP:0002875)	2.47959696
44	Abnormal rod and cone electroretinograms (HP:0008323)	2.45185614
45	Hemiparesis (HP:0001269)	2.44054507
46	Male pseudohermaphroditism (HP:0000037)	2.38755464
47	Aplastic anemia (HP:0001915)	2.37701928
48	Tubular atrophy (HP:0000092)	2.31753529
49	Atonic seizures (HP:0010819)	2.30064953
50	Abolished electroretinogram (ERG) (HP:0000550)	2.29860674
51	Febrile seizures (HP:0002373)	2.29461476
52	Bile duct proliferation (HP:0001408)	2.29422196
53	Abnormal biliary tract physiology (HP:0012439)	2.29422196
54	Stomach cancer (HP:0012126)	2.28894685
55	Postaxial foot polydactyly (HP:0001830)	2.28662035
56	Absent speech (HP:0001344)	2.26674836
57	Cystic liver disease (HP:0006706)	2.25787708
58	Gait imbalance (HP:0002141)	2.23113908
59	Congenital hepatic fibrosis (HP:0002612)	2.20962551
60	Abnormal respiratory motile cilium physiology (HP:0012261)	2.20764928
61	Congenital primary aphakia (HP:0007707)	2.19070364
62	Cerebral edema (HP:0002181)	2.18914128
63	Abnormal respiratory motile cilium morphology (HP:0005938)	2.15983401
64	Abnormal respiratory epithelium morphology (HP:0012253)	2.15983401
65	Type II lissencephaly (HP:0007260)	2.12770930
66	Thyroiditis (HP:0100646)	2.12385722
67	Optic disc pallor (HP:0000543)	2.11398543
68	Increased serum lactate (HP:0002151)	2.08842757
69	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.08056570
70	Nephrogenic diabetes insipidus (HP:0009806)	2.07418355
71	Vitreoretinal degeneration (HP:0000655)	2.07237607
72	T lymphocytopenia (HP:0005403)	2.05243803
73	Abnormality of renal resorption (HP:0011038)	2.04737732
74	Congenital, generalized hypertrichosis (HP:0004540)	2.01374496
75	Retinal dysplasia (HP:0007973)	2.01048674
76	Lactic acidosis (HP:0003128)	1.99513789
77	Central scotoma (HP:0000603)	1.99385345
78	Absent/shortened dynein arms (HP:0200106)	1.99106894
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.99106894
80	Polyuria (HP:0000103)	1.95478703
81	Generalized aminoaciduria (HP:0002909)	1.94236953
82	Encephalitis (HP:0002383)	1.92253050
83	Combined immunodeficiency (HP:0005387)	1.89303288
84	Abnormality of T cell number (HP:0011839)	1.85177131
85	Type I transferrin isoform profile (HP:0003642)	1.81568609
86	Abnormal albumin level (HP:0012116)	1.81022058
87	Hypoalbuminemia (HP:0003073)	1.81022058
88	Respiratory failure (HP:0002878)	1.78812376
89	Glycosuria (HP:0003076)	1.78290753
90	Abnormality of urine glucose concentration (HP:0011016)	1.78290753
91	Postaxial hand polydactyly (HP:0001162)	1.75533043
92	Cerebral hypomyelination (HP:0006808)	1.75405095
93	Abnormality of eosinophils (HP:0001879)	1.75323092
94	Congenital stationary night blindness (HP:0007642)	1.75023034
95	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.74551768
96	Hypoplasia of the thymus (HP:0000778)	1.74062308
97	Anencephaly (HP:0002323)	1.73851148
98	Vaginal atresia (HP:0000148)	1.73005351
99	Genital tract atresia (HP:0001827)	1.71695512
100	Exercise intolerance (HP:0003546)	1.71504601

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.43247394
2	ZAK	3.26800045
3	KDR	3.15086010
4	VRK2	2.56289739
5	WNK3	2.54060333
6	BCKDK	2.36831551
7	BUB1	2.23122138
8	MAP4K2	2.22760650
9	CASK	2.09010795
10	MAP3K12	2.04778149
11	TAF1	2.00698759
12	TESK2	1.87449784
13	NUAK1	1.85204957
14	MAP2K7	1.78358287
15	ADRBK2	1.75552332
16	WNK4	1.68412375
17	MAPKAPK3	1.59157590
18	RPS6KA4	1.45711494
19	GRK1	1.45568160
20	BMPR1B	1.44670676
21	DAPK1	1.44304705
22	MARK1	1.44074845
23	TAOK3	1.40150261
24	VRK1	1.35853341
25	LIMK1	1.35135632
26	TRIM28	1.30866249
27	MAP3K4	1.30825293
28	CCNB1	1.30200170
29	NEK1	1.23940276
30	BRSK2	1.23285794
31	CDC7	1.20686993
32	MAPK13	1.19093353
33	MYLK	1.14645265
34	STK16	1.12888002
35	ITK	1.09642818
36	FRK	1.07939399
37	SRPK1	1.04325041
38	EIF2AK3	1.03757340
39	CSNK1G3	1.03635984
40	NME1	0.97529784
41	DYRK2	0.97199073
42	PRKCQ	0.92267428
43	CSNK1G1	0.92205269
44	STK38L	0.88597945
45	MST4	0.88386287
46	BRD4	0.87798147
47	SYK	0.87589475
48	CSNK1A1L	0.86636401
49	PTK2B	0.85095201
50	CDK8	0.85079045
51	PHKG1	0.83473033
52	PHKG2	0.83473033
53	CSNK1G2	0.83177849
54	MAPKAPK5	0.82359199
55	FES	0.79294589
56	TSSK6	0.79123753
57	MAP4K1	0.78415018
58	TIE1	0.76699402
59	BCR	0.76476217
60	PINK1	0.74394427
61	TEC	0.73899352
62	TESK1	0.73338686
63	WEE1	0.72998464
64	PLK1	0.70860301
65	STK39	0.70656228
66	ATR	0.69632729
67	PLK3	0.69617096
68	GRK5	0.63731578
69	TLK1	0.62971822
70	OBSCN	0.62701304
71	RPS6KA5	0.62624774
72	PIK3CA	0.61743615
73	MINK1	0.61102843
74	ACVR1B	0.60117143
75	BTK	0.56143397
76	LCK	0.55806282
77	MAP2K6	0.54488687
78	LYN	0.54112522
79	AURKA	0.53125638
80	PLK4	0.49328763
81	ROCK1	0.49319253
82	IKBKB	0.48583783
83	INSRR	0.48415599
84	CAMK2A	0.46323985
85	TNK2	0.45809455
86	MAP3K6	0.43024554
87	PRKACA	0.42453135
88	NTRK1	0.41555521
89	CHEK2	0.41347244
90	CSNK1A1	0.40947462
91	ADRBK1	0.39853846
92	GRK6	0.39650569
93	ZAP70	0.39608722
94	FYN	0.39536165
95	BRSK1	0.39269645
96	CSNK2A1	0.38904084
97	PLK2	0.38030249
98	ATM	0.37912183
99	CAMK2G	0.37084647
100	IGF1R	0.36755923

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.04954677
2	Proteasome_Homo sapiens_hsa03050	3.97189267
3	Parkinsons disease_Homo sapiens_hsa05012	3.28005675
4	Primary immunodeficiency_Homo sapiens_hsa05340	3.16240529
5	RNA polymerase_Homo sapiens_hsa03020	2.49634364
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.48882515
7	Huntingtons disease_Homo sapiens_hsa05016	2.42637785
8	DNA replication_Homo sapiens_hsa03030	2.29758071
9	Alzheimers disease_Homo sapiens_hsa05010	2.21278645
10	Mismatch repair_Homo sapiens_hsa03430	2.14239021
11	Homologous recombination_Homo sapiens_hsa03440	2.05195736
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.04758904
13	Protein export_Homo sapiens_hsa03060	1.97470894
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88793240
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86362816
16	Propanoate metabolism_Homo sapiens_hsa00640	1.84617861
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.80847798
18	Ribosome_Homo sapiens_hsa03010	1.68901706
19	Butanoate metabolism_Homo sapiens_hsa00650	1.68846677
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63152705
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.63121738
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.59763715
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.53158446
24	Nicotine addiction_Homo sapiens_hsa05033	1.49930926
25	Base excision repair_Homo sapiens_hsa03410	1.37706466
26	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.35839795
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35189843
28	RNA degradation_Homo sapiens_hsa03018	1.35140547
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.34130875
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25769260
31	One carbon pool by folate_Homo sapiens_hsa00670	1.25431273
32	Peroxisome_Homo sapiens_hsa04146	1.25315335
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24253992
34	Antigen processing and presentation_Homo sapiens_hsa04612	1.21881465
35	Allograft rejection_Homo sapiens_hsa05330	1.20028776
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16729365
37	Basal transcription factors_Homo sapiens_hsa03022	1.14921085
38	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.12213426
39	Fatty acid elongation_Homo sapiens_hsa00062	1.11771616
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08279403
41	Phototransduction_Homo sapiens_hsa04744	1.06980307
42	Regulation of autophagy_Homo sapiens_hsa04140	1.02263727
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98523559
44	Purine metabolism_Homo sapiens_hsa00230	0.94795268
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93445471
46	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.90925459
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.90325365
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.89142195
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.88607545
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88173484
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87700909
52	Spliceosome_Homo sapiens_hsa03040	0.85473293
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.82247216
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81142544
55	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.76740579
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.73135335
57	Retinol metabolism_Homo sapiens_hsa00830	0.72633116
58	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.70731054
59	Fatty acid degradation_Homo sapiens_hsa00071	0.70080963
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66556984
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65612712
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.64436354
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61374201
64	Shigellosis_Homo sapiens_hsa05131	0.60678847
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.58553860
66	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.56961386
67	Salmonella infection_Homo sapiens_hsa05132	0.55564434
68	Metabolic pathways_Homo sapiens_hsa01100	0.55386569
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54923288
70	Amphetamine addiction_Homo sapiens_hsa05031	0.54885949
71	Folate biosynthesis_Homo sapiens_hsa00790	0.54881458
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53929330
73	Caffeine metabolism_Homo sapiens_hsa00232	0.53248115
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52634616
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.50986052
76	Morphine addiction_Homo sapiens_hsa05032	0.50362534
77	RNA transport_Homo sapiens_hsa03013	0.50285630
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.49844900
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49110691
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48634342
81	Taste transduction_Homo sapiens_hsa04742	0.47172986
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46241091
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.46142180
84	Olfactory transduction_Homo sapiens_hsa04740	0.46090475
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45482236
86	Dopaminergic synapse_Homo sapiens_hsa04728	0.43178242
87	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42678965
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.42421370
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42010943
90	GABAergic synapse_Homo sapiens_hsa04727	0.40297786
91	Asthma_Homo sapiens_hsa05310	0.38548614
92	Circadian entrainment_Homo sapiens_hsa04713	0.37877653
93	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.34763852
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30632344
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29257756
96	Alcoholism_Homo sapiens_hsa05034	0.26511257
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24063266
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.23002298
99	Glutamatergic synapse_Homo sapiens_hsa04724	0.21266633
100	Glutathione metabolism_Homo sapiens_hsa00480	0.21211077

SMARCE1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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