SMARCE1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)6.41135341
2cytidine deamination (GO:0009972)6.41135341
3cytidine metabolic process (GO:0046087)6.41135341
4DNA deamination (GO:0045006)5.96726667
5NIK/NF-kappaB signaling (GO:0038061)5.64852250
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.63827501
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.61881370
8sequestering of actin monomers (GO:0042989)4.95845869
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.92108596
10positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.72313919
11positive regulation of natural killer cell mediated immunity (GO:0002717)4.69853226
12actin nucleation (GO:0045010)4.33885288
13regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.25390119
14regulation of natural killer cell mediated immunity (GO:0002715)4.25390119
15positive T cell selection (GO:0043368)4.00287978
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.98669078
17programmed necrotic cell death (GO:0097300)3.96121655
18positive regulation of tolerance induction (GO:0002645)3.95763656
19preassembly of GPI anchor in ER membrane (GO:0016254)3.91891092
20GPI anchor biosynthetic process (GO:0006506)3.78192574
21GPI anchor metabolic process (GO:0006505)3.71046454
22cellular ketone body metabolic process (GO:0046950)3.69910944
23regulation of T cell tolerance induction (GO:0002664)3.61112951
24electron transport chain (GO:0022900)3.60314265
25regulation of RIG-I signaling pathway (GO:0039535)3.60155068
26respiratory electron transport chain (GO:0022904)3.55266409
27necrotic cell death (GO:0070265)3.53381087
28regulation of leukocyte mediated cytotoxicity (GO:0001910)3.53125217
29negative regulation of T cell apoptotic process (GO:0070233)3.52725359
30mannosylation (GO:0097502)3.43112101
31positive thymic T cell selection (GO:0045059)3.43055845
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.40702496
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40169486
34indole-containing compound catabolic process (GO:0042436)3.37163427
35indolalkylamine catabolic process (GO:0046218)3.37163427
36tryptophan catabolic process (GO:0006569)3.37163427
37ketone body metabolic process (GO:1902224)3.32216701
38purine deoxyribonucleotide catabolic process (GO:0009155)3.31122737
39regulation of tolerance induction (GO:0002643)3.29031725
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.24678920
41negative regulation of viral genome replication (GO:0045071)3.23260938
42pyrimidine nucleoside catabolic process (GO:0046135)3.21966490
43cytolysis (GO:0019835)3.20915417
44positive regulation of interleukin-8 secretion (GO:2000484)3.16304909
45kynurenine metabolic process (GO:0070189)3.15429575
46ATP synthesis coupled proton transport (GO:0015986)3.13480851
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13480851
48regulation of ruffle assembly (GO:1900027)3.12091846
49eosinophil chemotaxis (GO:0048245)3.11707637
50regulation of cell killing (GO:0031341)3.11561359
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10552068
52positive regulation of calcium-mediated signaling (GO:0050850)3.10469785
53cornea development in camera-type eye (GO:0061303)3.09401304
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98905977
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98905977
56regulation of regulatory T cell differentiation (GO:0045589)2.95762609
57regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.95056211
58positive regulation of cell killing (GO:0031343)2.89554370
59purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88634918
60behavioral response to ethanol (GO:0048149)2.87602341
61regulation of protein polyubiquitination (GO:1902914)2.86131899
62purine deoxyribonucleotide metabolic process (GO:0009151)2.84916584
63platelet dense granule organization (GO:0060155)2.84906396
64positive regulation of prostaglandin secretion (GO:0032308)2.84142310
65eosinophil migration (GO:0072677)2.83822049
66sulfation (GO:0051923)2.81396211
67negative T cell selection (GO:0043383)2.80561896
68amine catabolic process (GO:0009310)2.80313978
69cellular biogenic amine catabolic process (GO:0042402)2.80313978
70cytochrome complex assembly (GO:0017004)2.78387377
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.78287815
72C-terminal protein amino acid modification (GO:0018410)2.77599734
73positive regulation of interleukin-1 beta secretion (GO:0050718)2.77307725
74xenobiotic catabolic process (GO:0042178)2.76257845
75establishment of protein localization to mitochondrial membrane (GO:0090151)2.75370716
76necroptotic process (GO:0070266)2.74239471
77alkaloid metabolic process (GO:0009820)2.69228990
78natural killer cell activation (GO:0030101)2.68584892
79tryptophan metabolic process (GO:0006568)2.65300724
80negative regulation of cell killing (GO:0031342)2.65037761
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65037761
82response to interferon-beta (GO:0035456)2.63367629
83regulation of interleukin-2 biosynthetic process (GO:0045076)2.63177078
84regulation of interleukin-8 secretion (GO:2000482)2.61870698
85positive regulation of fatty acid beta-oxidation (GO:0032000)2.61606173
86negative regulation of oxidoreductase activity (GO:0051354)2.60515220
87glycolipid biosynthetic process (GO:0009247)2.60385152
88positive regulation of B cell differentiation (GO:0045579)2.59837820
89positive regulation of interleukin-1 secretion (GO:0050716)2.59713542
90positive regulation of fatty acid transport (GO:2000193)2.59660445
91C-terminal protein lipidation (GO:0006501)2.58264280
92indolalkylamine metabolic process (GO:0006586)2.56331287
93positive regulation of icosanoid secretion (GO:0032305)2.56213654
94positive regulation of interleukin-4 production (GO:0032753)2.55615353
95regulation of B cell receptor signaling pathway (GO:0050855)2.55038457
96hydrogen ion transmembrane transport (GO:1902600)2.52760745
97regulation of T cell apoptotic process (GO:0070232)2.51127133
98regulation of interleukin-1 beta secretion (GO:0050706)2.48944201
99regulation of activation of Janus kinase activity (GO:0010533)2.47339147
100negative regulation of lymphocyte apoptotic process (GO:0070229)2.46685741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.16245608
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93602967
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.76314627
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51276596
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42538504
6EZH2_22144423_ChIP-Seq_EOC_Human2.49725229
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.46491156
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.14589469
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.05336916
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04541065
11VDR_22108803_ChIP-Seq_LS180_Human2.03492640
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98555420
13TAF15_26573619_Chip-Seq_HEK293_Human1.97576185
14GBX2_23144817_ChIP-Seq_PC3_Human1.94870993
15RUNX_20019798_ChIP-Seq_JUKART_Human1.89636078
16ZNF274_21170338_ChIP-Seq_K562_Hela1.84965573
17MYB_26560356_Chip-Seq_TH2_Human1.78870193
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72876940
19GATA3_27048872_Chip-Seq_THYMUS_Human1.68551358
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67664386
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.66259880
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62943846
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60258587
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59879845
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52450220
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52282585
27GATA3_26560356_Chip-Seq_TH2_Human1.51380783
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50551274
29CBP_20019798_ChIP-Seq_JUKART_Human1.50097405
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50097405
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44976514
32HTT_18923047_ChIP-ChIP_STHdh_Human1.43997642
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42772802
34SCL_19346495_ChIP-Seq_HPC-7_Human1.42759355
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42546887
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40401619
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.32901071
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32395503
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31859517
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31859517
41DROSHA_22980978_ChIP-Seq_HELA_Human1.29553158
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28767830
43P300_19829295_ChIP-Seq_ESCs_Human1.28355026
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27933963
45AR_20517297_ChIP-Seq_VCAP_Human1.24116363
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23067139
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22166602
48IGF1R_20145208_ChIP-Seq_DFB_Human1.19167153
49VDR_23849224_ChIP-Seq_CD4+_Human1.18048937
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17923527
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17845744
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.17049973
53BCAT_22108803_ChIP-Seq_LS180_Human1.16853828
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16768244
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16581425
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.16581425
57RXR_22108803_ChIP-Seq_LS180_Human1.15762837
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15319541
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.14677208
60SOX2_19829295_ChIP-Seq_ESCs_Human1.14338399
61NANOG_19829295_ChIP-Seq_ESCs_Human1.14338399
62GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.13562302
63REST_21632747_ChIP-Seq_MESCs_Mouse1.12332560
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11983592
65RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11381286
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.11183976
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08794479
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.08337770
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08138863
70MYC_19829295_ChIP-Seq_ESCs_Human1.06147433
71MYB_26560356_Chip-Seq_TH1_Human1.05625060
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05393828
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04509142
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03682107
75HOXB7_26014856_ChIP-Seq_BT474_Human1.03643596
76NCOR_22424771_ChIP-Seq_293T_Human1.03446843
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03412085
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03219937
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03146229
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02213599
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01851832
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00973593
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00944692
84ERA_21632823_ChIP-Seq_H3396_Human1.00291363
85TP53_22573176_ChIP-Seq_HFKS_Human1.00174068
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.99363863
87ER_23166858_ChIP-Seq_MCF-7_Human0.99214982
88ERG_20517297_ChIP-Seq_VCAP_Human0.98737844
89IRF8_27001747_Chip-Seq_BMDM_Mouse0.96694141
90STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95771298
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93463687
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93330644
93SMRT_27268052_Chip-Seq_Bcells_Human0.93029159
94TAF2_19829295_ChIP-Seq_ESCs_Human0.91756325
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91382948
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90870090
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.90723710
98VDR_24787735_ChIP-Seq_THP-1_Human0.90515015
99GATA3_26560356_Chip-Seq_TH1_Human0.89584161
100FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88940030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.66382961
2MP0009785_altered_susceptibility_to3.07065619
3MP0008877_abnormal_DNA_methylation2.67571402
4MP0001835_abnormal_antigen_presentation2.67222963
5MP0000372_irregular_coat_pigmentation2.25832305
6MP0001790_abnormal_immune_system2.24938625
7MP0005387_immune_system_phenotype2.24938625
8MP0003011_delayed_dark_adaptation2.15113390
9MP0005000_abnormal_immune_tolerance2.10678107
10MP0002166_altered_tumor_susceptibility2.08363774
11MP0001800_abnormal_humoral_immune2.07166206
12MP0002148_abnormal_hypersensitivity_rea2.05217670
13MP0002909_abnormal_adrenal_gland2.02155624
14MP0005645_abnormal_hypothalamus_physiol1.98749546
15MP0005025_abnormal_response_to1.98595013
16MP0001905_abnormal_dopamine_level1.92127532
17MP0009764_decreased_sensitivity_to1.91840319
18MP0002723_abnormal_immune_serum1.90123889
19MP0003787_abnormal_imprinting1.85822991
20MP0002420_abnormal_adaptive_immunity1.84501376
21MP0006276_abnormal_autonomic_nervous1.83049103
22MP0001819_abnormal_immune_cell1.78522859
23MP0006082_CNS_inflammation1.72042337
24MP0004142_abnormal_muscle_tone1.67878651
25MP0002277_abnormal_respiratory_mucosa1.64691607
26MP0002006_tumorigenesis1.60545631
27MP0003763_abnormal_thymus_physiology1.59193464
28MP0005551_abnormal_eye_electrophysiolog1.58823900
29MP0001986_abnormal_taste_sensitivity1.55366362
30MP0000685_abnormal_immune_system1.53239970
31MP0006072_abnormal_retinal_apoptosis1.52382477
32MP0000716_abnormal_immune_system1.50628170
33MP0002452_abnormal_antigen_presenting1.50372723
34MP0002933_joint_inflammation1.48460345
35MP0006035_abnormal_mitochondrial_morpho1.46094275
36MP0005253_abnormal_eye_physiology1.44332593
37MP0002009_preneoplasia1.40341919
38MP0003195_calcinosis1.38708960
39MP0009333_abnormal_splenocyte_physiolog1.37071004
40MP0001968_abnormal_touch/_nociception1.36288202
41MP0000689_abnormal_spleen_morphology1.35366770
42MP0008872_abnormal_physiological_respon1.35232252
43MP0002138_abnormal_hepatobiliary_system1.35094043
44MP0005377_hearing/vestibular/ear_phenot1.33948053
45MP0003878_abnormal_ear_physiology1.33948053
46MP0001501_abnormal_sleep_pattern1.32692615
47MP0002398_abnormal_bone_marrow1.30262982
48MP0005310_abnormal_salivary_gland1.29104641
49MP0003646_muscle_fatigue1.28295075
50MP0001919_abnormal_reproductive_system1.26289436
51MP0005075_abnormal_melanosome_morpholog1.26013517
52MP0003448_altered_tumor_morphology1.23568839
53MP0001873_stomach_inflammation1.23104153
54MP0001845_abnormal_inflammatory_respons1.20605086
55MP0002419_abnormal_innate_immunity1.16549052
56MP0004019_abnormal_vitamin_homeostasis1.16256598
57MP0004510_myositis1.12937997
58MP0003137_abnormal_impulse_conducting1.11084658
59MP0002722_abnormal_immune_system1.09062710
60MP0002405_respiratory_system_inflammati1.08924216
61MP0005646_abnormal_pituitary_gland1.07193170
62MP0008875_abnormal_xenobiotic_pharmacok1.04657804
63MP0002429_abnormal_blood_cell1.03985841
64MP0002102_abnormal_ear_morphology1.02916744
65MP0005464_abnormal_platelet_physiology1.02530064
66MP0002733_abnormal_thermal_nociception1.02383168
67MP0002095_abnormal_skin_pigmentation1.02163663
68MP0001853_heart_inflammation1.02003799
69MP0005423_abnormal_somatic_nervous1.01510038
70MP0009745_abnormal_behavioral_response1.00556958
71MP0002272_abnormal_nervous_system0.99962566
72MP0000703_abnormal_thymus_morphology0.99834045
73MP0001970_abnormal_pain_threshold0.99637667
74MP0009046_muscle_twitch0.98384285
75MP0008469_abnormal_protein_level0.97698478
76MP0004742_abnormal_vestibular_system0.96956544
77MP0002736_abnormal_nociception_after0.96229341
78MP0002693_abnormal_pancreas_physiology0.95849185
79MP0002876_abnormal_thyroid_physiology0.95646483
80MP0003724_increased_susceptibility_to0.93549167
81MP0000639_abnormal_adrenal_gland0.89477180
82MP0000230_abnormal_systemic_arterial0.89016240
83MP0003866_abnormal_defecation0.88241961
84MP0005167_abnormal_blood-brain_barrier0.88211877
85MP0005166_decreased_susceptibility_to0.87963108
86MP0002064_seizures0.87798754
87MP0000631_abnormal_neuroendocrine_gland0.85809437
88MP0000383_abnormal_hair_follicle0.85257271
89MP0003191_abnormal_cellular_cholesterol0.82830732
90MP0001502_abnormal_circadian_rhythm0.79024996
91MP0003075_altered_response_to0.78536375
92MP0001963_abnormal_hearing_physiology0.77050633
93MP0005389_reproductive_system_phenotype0.75114783
94MP0002638_abnormal_pupillary_reflex0.74338434
95MP0001485_abnormal_pinna_reflex0.74025012
96MP0002837_dystrophic_cardiac_calcinosis0.74010009
97MP0005084_abnormal_gallbladder_morpholo0.73985225
98MP0001661_extended_life_span0.73711782
99MP0009763_increased_sensitivity_to0.73074975
100MP0001764_abnormal_homeostasis0.72866633

Predicted human phenotypes

RankGene SetZ-score
1Hepatocellular necrosis (HP:0001404)3.83748187
2Mitochondrial inheritance (HP:0001427)3.80314943
3Severe combined immunodeficiency (HP:0004430)3.79199007
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.54367332
5Elevated erythrocyte sedimentation rate (HP:0003565)3.45871387
6Amyotrophic lateral sclerosis (HP:0007354)3.36870076
7IgG deficiency (HP:0004315)3.32569252
8Acute necrotizing encephalopathy (HP:0006965)3.28763169
9Hepatic necrosis (HP:0002605)3.28335233
10Increased CSF lactate (HP:0002490)3.21892371
11Abnormal mitochondria in muscle tissue (HP:0008316)3.06753817
12Pancreatic fibrosis (HP:0100732)3.04939121
13Thyroiditis (HP:0100646)2.99336867
14Increased IgM level (HP:0003496)2.98041220
15Hypoproteinemia (HP:0003075)2.94032898
16Combined immunodeficiency (HP:0005387)2.91416075
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.89953166
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.89953166
19Decreased central vision (HP:0007663)2.88546257
20Increased hepatocellular lipid droplets (HP:0006565)2.88039607
21Increased intramyocellular lipid droplets (HP:0012240)2.78977274
22Generalized aminoaciduria (HP:0002909)2.76358325
23Progressive macrocephaly (HP:0004481)2.75799728
24Autoimmune hemolytic anemia (HP:0001890)2.75411636
25Global brain atrophy (HP:0002283)2.75070121
26Recurrent bronchitis (HP:0002837)2.72347228
27Congenital stationary night blindness (HP:0007642)2.71585873
28Attenuation of retinal blood vessels (HP:0007843)2.70619458
29Lipid accumulation in hepatocytes (HP:0006561)2.67833942
30Pancreatic cysts (HP:0001737)2.67386788
31True hermaphroditism (HP:0010459)2.64152374
32Acute encephalopathy (HP:0006846)2.63941295
33Abnormality of midbrain morphology (HP:0002418)2.54421901
34Molar tooth sign on MRI (HP:0002419)2.54421901
35Abnormality of eosinophils (HP:0001879)2.48413695
36Abnormal rod and cone electroretinograms (HP:0008323)2.48381192
37Aplastic anemia (HP:0001915)2.45290562
38T lymphocytopenia (HP:0005403)2.45155297
39Renal Fanconi syndrome (HP:0001994)2.45083946
40Increased muscle lipid content (HP:0009058)2.38349235
41Methylmalonic aciduria (HP:0012120)2.37969944
42Parakeratosis (HP:0001036)2.36580870
43Methylmalonic acidemia (HP:0002912)2.34363358
44Abnormality of the prostate (HP:0008775)2.34093514
45Encephalitis (HP:0002383)2.30712954
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30555917
47Spastic paraparesis (HP:0002313)2.29929101
48Severe visual impairment (HP:0001141)2.24456287
49Abnormality of T cell number (HP:0011839)2.24118552
50Hyperglycinemia (HP:0002154)2.20573010
51Furrowed tongue (HP:0000221)2.15855426
52Focal motor seizures (HP:0011153)2.15211592
53Prostate neoplasm (HP:0100787)2.14738699
54Leukocytosis (HP:0001974)2.12278490
55Panhypogammaglobulinemia (HP:0003139)2.09075080
56J-shaped sella turcica (HP:0002680)2.08860448
57Optic disc pallor (HP:0000543)2.08453178
58Neuroendocrine neoplasm (HP:0100634)2.05921978
59Exertional dyspnea (HP:0002875)2.05441870
60Cerebral edema (HP:0002181)2.05396791
61Atrophy/Degeneration involving motor neurons (HP:0007373)2.02450761
62Facial diplegia (HP:0001349)2.01867279
63Hematochezia (HP:0002573)2.01214783
643-Methylglutaconic aciduria (HP:0003535)2.00723212
65Hemiplegia (HP:0002301)2.00057702
66Abnormality of T cells (HP:0002843)2.00046877
67Lymphopenia (HP:0001888)1.99562431
68Abnormality of the renal cortex (HP:0011035)1.98820782
69Ketosis (HP:0001946)1.97601956
70Progressive cerebellar ataxia (HP:0002073)1.96628410
71Congenital, generalized hypertrichosis (HP:0004540)1.95231921
72Abnormal drinking behavior (HP:0030082)1.95031491
73Polydipsia (HP:0001959)1.95031491
74Large for gestational age (HP:0001520)1.93333382
75Abnormal number of erythroid precursors (HP:0012131)1.93181352
76Nephronophthisis (HP:0000090)1.91576590
77Meningitis (HP:0001287)1.90402555
78Chronic sinusitis (HP:0011109)1.89232432
79Leukodystrophy (HP:0002415)1.88863005
80Myositis (HP:0100614)1.88766971
81Genetic anticipation (HP:0003743)1.88686897
82Abolished electroretinogram (ERG) (HP:0000550)1.87170319
83CNS demyelination (HP:0007305)1.85389722
84Progressive inability to walk (HP:0002505)1.82996411
85Eosinophilia (HP:0001880)1.82654103
86Ketoacidosis (HP:0001993)1.82475384
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82396033
88Spontaneous hematomas (HP:0007420)1.81702581
89Renal cortical cysts (HP:0000803)1.81469940
90Abnormality of macular pigmentation (HP:0008002)1.79755299
91Palpebral edema (HP:0100540)1.79511821
92Episodic fever (HP:0001954)1.79464862
93Obstructive lung disease (HP:0006536)1.74900766
94Chronic obstructive pulmonary disease (HP:0006510)1.74900766
95Respiratory failure (HP:0002878)1.73251903
96Constricted visual fields (HP:0001133)1.73207261
97Abnormality of the intervertebral disk (HP:0005108)1.71991547
98Respiratory difficulties (HP:0002880)1.70568303
99Abnormality of the renal medulla (HP:0100957)1.69308072
100Microcytic anemia (HP:0001935)1.69220445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.27598781
2TXK4.46447978
3TESK23.54112277
4ADRBK23.18042414
5ZAK3.12612637
6MAP3K122.89065659
7FRK2.69503547
8MAP2K72.65480142
9BCKDK2.64973837
10MAP4K22.20677218
11MAP4K12.06820287
12TRIM282.03729112
13MAP3K41.98903838
14WNK31.91610522
15GRK11.89705193
16LIMK11.83386167
17TESK11.67024824
18PIK3CA1.40412965
19SYK1.33763033
20VRK21.31646978
21JAK31.31102213
22ERBB31.30582608
23MAP3K61.25543649
24GRK61.20222655
25TLK11.20104611
26ITK1.18353334
27GRK71.17003790
28PRKCQ1.12265616
29IKBKE1.11513211
30KIT1.10869838
31CAMKK21.07623952
32VRK11.06796689
33MAP3K111.02641042
34PINK11.02533299
35TAOK31.01144687
36LRRK20.99578920
37LYN0.98085268
38MAPK130.97983569
39MYLK0.97910857
40MAPKAPK30.96066911
41STK160.96045132
42LCK0.95801043
43TNK20.91557541
44CSF1R0.91547088
45TIE10.91174993
46PIM10.90236318
47MAP3K50.88403845
48TEC0.87881566
49BUB10.81835750
50MAP2K60.79510730
51FES0.79161146
52PTK2B0.77709805
53FLT30.77388403
54MST40.76410182
55ADRBK10.75807207
56BTK0.74737268
57NTRK20.73509395
58ZAP700.72822381
59WNK40.71091118
60PIM20.68579174
61CSK0.67918837
62DYRK1B0.66141812
63INSRR0.64840766
64RIPK40.64002795
65PKN10.62148813
66DAPK10.61937227
67IRAK40.61675338
68RPS6KA50.61153165
69DAPK20.60285284
70TYRO30.58808412
71IKBKB0.57954729
72DYRK20.57046509
73NUAK10.55674141
74UHMK10.55670088
75ROCK10.54792682
76AKT30.54727988
77MAP2K40.51367806
78MAPKAPK50.48417810
79OBSCN0.48232372
80IGF1R0.47586882
81CDK30.47228991
82BLK0.45691666
83YES10.44552513
84GRK50.44275701
85CAMK2A0.44244062
86PRKACA0.43358648
87FYN0.41222594
88JAK20.39944567
89PIK3CG0.39294806
90PRKCA0.36271757
91PLK20.33989233
92CAMK40.29308657
93ABL10.28365172
94EGFR0.28169869
95BMPR20.27916059
96PRKCE0.27564088
97MAPK30.27563030
98CSNK2A10.27389114
99CASK0.27295605
100CAMK10.26446231

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.77662361
2Primary immunodeficiency_Homo sapiens_hsa053403.69254253
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33347574
4Parkinsons disease_Homo sapiens_hsa050123.09823037
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.95023394
6Proteasome_Homo sapiens_hsa030502.93311756
7Graft-versus-host disease_Homo sapiens_hsa053322.56137226
8Autoimmune thyroid disease_Homo sapiens_hsa053202.53104593
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37375938
10Allograft rejection_Homo sapiens_hsa053302.25579931
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.16390981
12Type I diabetes mellitus_Homo sapiens_hsa049402.06517195
13Alzheimers disease_Homo sapiens_hsa050102.05832838
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05190851
15Butanoate metabolism_Homo sapiens_hsa006501.96799240
16Hematopoietic cell lineage_Homo sapiens_hsa046401.89347668
17Rheumatoid arthritis_Homo sapiens_hsa053231.85626463
18Huntingtons disease_Homo sapiens_hsa050161.77307593
19Antigen processing and presentation_Homo sapiens_hsa046121.62249413
20T cell receptor signaling pathway_Homo sapiens_hsa046601.58987230
21Caffeine metabolism_Homo sapiens_hsa002321.56796130
22Protein export_Homo sapiens_hsa030601.51279112
23Cardiac muscle contraction_Homo sapiens_hsa042601.49936988
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.48441805
25Malaria_Homo sapiens_hsa051441.44990758
26Tryptophan metabolism_Homo sapiens_hsa003801.43884329
27Asthma_Homo sapiens_hsa053101.39202640
28Phototransduction_Homo sapiens_hsa047441.37447840
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32617834
30RNA polymerase_Homo sapiens_hsa030201.32386241
31Peroxisome_Homo sapiens_hsa041461.28306597
32Collecting duct acid secretion_Homo sapiens_hsa049661.25052132
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23946708
34ABC transporters_Homo sapiens_hsa020101.23570661
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.21075615
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16043695
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14751319
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13548980
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10728730
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09387869
41Salmonella infection_Homo sapiens_hsa051321.07539887
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01520768
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97119612
44Nicotine addiction_Homo sapiens_hsa050330.95026173
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92633503
46Nitrogen metabolism_Homo sapiens_hsa009100.91237064
47Staphylococcus aureus infection_Homo sapiens_hsa051500.88189824
48Measles_Homo sapiens_hsa051620.85991301
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84909483
50beta-Alanine metabolism_Homo sapiens_hsa004100.84507919
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81928781
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79729635
53Linoleic acid metabolism_Homo sapiens_hsa005910.79602106
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.78876448
55Basal transcription factors_Homo sapiens_hsa030220.75137309
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74606436
57Viral myocarditis_Homo sapiens_hsa054160.70904224
58Pertussis_Homo sapiens_hsa051330.70848481
59Olfactory transduction_Homo sapiens_hsa047400.70295331
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68047523
61Taste transduction_Homo sapiens_hsa047420.66826200
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64479586
63Morphine addiction_Homo sapiens_hsa050320.63574437
64Steroid biosynthesis_Homo sapiens_hsa001000.63145701
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62301032
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61330579
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60141905
68Fatty acid biosynthesis_Homo sapiens_hsa000610.55489729
69Fatty acid degradation_Homo sapiens_hsa000710.55162857
70Chemical carcinogenesis_Homo sapiens_hsa052040.54870221
71Systemic lupus erythematosus_Homo sapiens_hsa053220.52680334
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51683038
73Retinol metabolism_Homo sapiens_hsa008300.49583589
74Mineral absorption_Homo sapiens_hsa049780.47724797
75Tuberculosis_Homo sapiens_hsa051520.47540642
76Glycerolipid metabolism_Homo sapiens_hsa005610.47444680
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45761012
78Shigellosis_Homo sapiens_hsa051310.45183185
79Leishmaniasis_Homo sapiens_hsa051400.43129776
80Regulation of autophagy_Homo sapiens_hsa041400.42399443
81Amphetamine addiction_Homo sapiens_hsa050310.41937313
82TNF signaling pathway_Homo sapiens_hsa046680.41418307
83Calcium signaling pathway_Homo sapiens_hsa040200.40676149
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36650650
85Herpes simplex infection_Homo sapiens_hsa051680.36407178
86Homologous recombination_Homo sapiens_hsa034400.35815189
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33733816
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31874354
89Metabolic pathways_Homo sapiens_hsa011000.31509055
90Arachidonic acid metabolism_Homo sapiens_hsa005900.31018666
91Renin secretion_Homo sapiens_hsa049240.30619080
92Osteoclast differentiation_Homo sapiens_hsa043800.30466203
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29851709
94Phagosome_Homo sapiens_hsa041450.29564528
95Epstein-Barr virus infection_Homo sapiens_hsa051690.28350001
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28053637
97Propanoate metabolism_Homo sapiens_hsa006400.27125463
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26191571
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26080305
100Histidine metabolism_Homo sapiens_hsa003400.24247743

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