ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	6.41135341
2	cytidine catabolic process (GO:0006216)	6.41135341
3	cytidine deamination (GO:0009972)	6.41135341
4	DNA deamination (GO:0045006)	5.96726667
5	NIK/NF-kappaB signaling (GO:0038061)	5.64852250
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.63827501
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.61881370
8	sequestering of actin monomers (GO:0042989)	4.95845869
9	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.92108596
10	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.72313919
11	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.69853226
12	actin nucleation (GO:0045010)	4.33885288
13	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	4.25390119
14	regulation of natural killer cell mediated immunity (GO:0002715)	4.25390119
15	positive T cell selection (GO:0043368)	4.00287978
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.98669078
17	programmed necrotic cell death (GO:0097300)	3.96121655
18	positive regulation of tolerance induction (GO:0002645)	3.95763656
19	preassembly of GPI anchor in ER membrane (GO:0016254)	3.91891092
20	GPI anchor biosynthetic process (GO:0006506)	3.78192574
21	GPI anchor metabolic process (GO:0006505)	3.71046454
22	cellular ketone body metabolic process (GO:0046950)	3.69910944
23	regulation of T cell tolerance induction (GO:0002664)	3.61112951
24	electron transport chain (GO:0022900)	3.60314265
25	regulation of RIG-I signaling pathway (GO:0039535)	3.60155068
26	respiratory electron transport chain (GO:0022904)	3.55266409
27	necrotic cell death (GO:0070265)	3.53381087
28	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.53125217
29	negative regulation of T cell apoptotic process (GO:0070233)	3.52725359
30	mannosylation (GO:0097502)	3.43112101
31	positive thymic T cell selection (GO:0045059)	3.43055845
32	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.40702496
33	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.40169486
34	tryptophan catabolic process (GO:0006569)	3.37163427
35	indole-containing compound catabolic process (GO:0042436)	3.37163427
36	indolalkylamine catabolic process (GO:0046218)	3.37163427
37	ketone body metabolic process (GO:1902224)	3.32216701
38	purine deoxyribonucleotide catabolic process (GO:0009155)	3.31122737
39	regulation of tolerance induction (GO:0002643)	3.29031725
40	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.24678920
41	negative regulation of viral genome replication (GO:0045071)	3.23260938
42	pyrimidine nucleoside catabolic process (GO:0046135)	3.21966490
43	cytolysis (GO:0019835)	3.20915417
44	positive regulation of interleukin-8 secretion (GO:2000484)	3.16304909
45	kynurenine metabolic process (GO:0070189)	3.15429575
46	ATP synthesis coupled proton transport (GO:0015986)	3.13480851
47	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.13480851
48	regulation of ruffle assembly (GO:1900027)	3.12091846
49	eosinophil chemotaxis (GO:0048245)	3.11707637
50	regulation of cell killing (GO:0031341)	3.11561359
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.10552068
52	positive regulation of calcium-mediated signaling (GO:0050850)	3.10469785
53	cornea development in camera-type eye (GO:0061303)	3.09401304
54	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98905977
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98905977
56	regulation of regulatory T cell differentiation (GO:0045589)	2.95762609
57	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	2.95056211
58	positive regulation of cell killing (GO:0031343)	2.89554370
59	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.88634918
60	behavioral response to ethanol (GO:0048149)	2.87602341
61	regulation of protein polyubiquitination (GO:1902914)	2.86131899
62	purine deoxyribonucleotide metabolic process (GO:0009151)	2.84916584
63	platelet dense granule organization (GO:0060155)	2.84906396
64	positive regulation of prostaglandin secretion (GO:0032308)	2.84142310
65	eosinophil migration (GO:0072677)	2.83822049
66	sulfation (GO:0051923)	2.81396211
67	negative T cell selection (GO:0043383)	2.80561896
68	amine catabolic process (GO:0009310)	2.80313978
69	cellular biogenic amine catabolic process (GO:0042402)	2.80313978
70	cytochrome complex assembly (GO:0017004)	2.78387377
71	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.78287815
72	C-terminal protein amino acid modification (GO:0018410)	2.77599734
73	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.77307725
74	xenobiotic catabolic process (GO:0042178)	2.76257845
75	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.75370716
76	necroptotic process (GO:0070266)	2.74239471
77	alkaloid metabolic process (GO:0009820)	2.69228990
78	natural killer cell activation (GO:0030101)	2.68584892
79	tryptophan metabolic process (GO:0006568)	2.65300724
80	negative regulation of cell killing (GO:0031342)	2.65037761
81	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.65037761
82	response to interferon-beta (GO:0035456)	2.63367629
83	regulation of interleukin-2 biosynthetic process (GO:0045076)	2.63177078
84	regulation of interleukin-8 secretion (GO:2000482)	2.61870698
85	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.61606173
86	negative regulation of oxidoreductase activity (GO:0051354)	2.60515220
87	glycolipid biosynthetic process (GO:0009247)	2.60385152
88	positive regulation of B cell differentiation (GO:0045579)	2.59837820
89	positive regulation of interleukin-1 secretion (GO:0050716)	2.59713542
90	positive regulation of fatty acid transport (GO:2000193)	2.59660445
91	C-terminal protein lipidation (GO:0006501)	2.58264280
92	indolalkylamine metabolic process (GO:0006586)	2.56331287
93	positive regulation of icosanoid secretion (GO:0032305)	2.56213654
94	positive regulation of interleukin-4 production (GO:0032753)	2.55615353
95	regulation of B cell receptor signaling pathway (GO:0050855)	2.55038457
96	hydrogen ion transmembrane transport (GO:1902600)	2.52760745
97	regulation of T cell apoptotic process (GO:0070232)	2.51127133
98	regulation of interleukin-1 beta secretion (GO:0050706)	2.48944201
99	regulation of activation of Janus kinase activity (GO:0010533)	2.47339147
100	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.46685741

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.16245608
2	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.93602967
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.76314627
4	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.51276596
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.42538504
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.49725229
7	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.46491156
8	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.14589469
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05336916
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.04541065
11	VDR_22108803_ChIP-Seq_LS180_Human	2.03492640
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.98555420
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.97576185
14	GBX2_23144817_ChIP-Seq_PC3_Human	1.94870993
15	RUNX_20019798_ChIP-Seq_JUKART_Human	1.89636078
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.84965573
17	MYB_26560356_Chip-Seq_TH2_Human	1.78870193
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72876940
19	GATA3_27048872_Chip-Seq_THYMUS_Human	1.68551358
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67664386
21	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.66259880
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.62943846
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60258587
24	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.59879845
25	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.52450220
26	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.52282585
27	GATA3_26560356_Chip-Seq_TH2_Human	1.51380783
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.50551274
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50097405
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.50097405
31	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.44976514
32	HTT_18923047_ChIP-ChIP_STHdh_Human	1.43997642
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42772802
34	SCL_19346495_ChIP-Seq_HPC-7_Human	1.42759355
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42546887
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40401619
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32901071
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32395503
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31859517
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31859517
41	DROSHA_22980978_ChIP-Seq_HELA_Human	1.29553158
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.28767830
43	P300_19829295_ChIP-Seq_ESCs_Human	1.28355026
44	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.27933963
45	AR_20517297_ChIP-Seq_VCAP_Human	1.24116363
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.23067139
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22166602
48	IGF1R_20145208_ChIP-Seq_DFB_Human	1.19167153
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.18048937
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17923527
51	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.17845744
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17049973
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.16853828
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16768244
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16581425
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16581425
57	RXR_22108803_ChIP-Seq_LS180_Human	1.15762837
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15319541
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14677208
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14338399
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14338399
62	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13562302
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12332560
64	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.11983592
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11381286
66	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11183976
67	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08794479
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08337770
69	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08138863
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.06147433
71	MYB_26560356_Chip-Seq_TH1_Human	1.05625060
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.05393828
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04509142
74	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03682107
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03643596
76	NCOR_22424771_ChIP-Seq_293T_Human	1.03446843
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03412085
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03219937
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.03146229
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02213599
81	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.01851832
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.00973593
83	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.00944692
84	ERA_21632823_ChIP-Seq_H3396_Human	1.00291363
85	TP53_22573176_ChIP-Seq_HFKS_Human	1.00174068
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99363863
87	ER_23166858_ChIP-Seq_MCF-7_Human	0.99214982
88	ERG_20517297_ChIP-Seq_VCAP_Human	0.98737844
89	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.96694141
90	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.95771298
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93463687
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93330644
93	SMRT_27268052_Chip-Seq_Bcells_Human	0.93029159
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91756325
95	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91382948
96	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.90870090
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90723710
98	VDR_24787735_ChIP-Seq_THP-1_Human	0.90515015
99	GATA3_26560356_Chip-Seq_TH1_Human	0.89584161
100	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	0.88940030

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.66382961
2	MP0009785_altered_susceptibility_to	3.07065619
3	MP0008877_abnormal_DNA_methylation	2.67571402
4	MP0001835_abnormal_antigen_presentation	2.67222963
5	MP0000372_irregular_coat_pigmentation	2.25832305
6	MP0005387_immune_system_phenotype	2.24938625
7	MP0001790_abnormal_immune_system	2.24938625
8	MP0003011_delayed_dark_adaptation	2.15113390
9	MP0005000_abnormal_immune_tolerance	2.10678107
10	MP0002166_altered_tumor_susceptibility	2.08363774
11	MP0001800_abnormal_humoral_immune	2.07166206
12	MP0002148_abnormal_hypersensitivity_rea	2.05217670
13	MP0002909_abnormal_adrenal_gland	2.02155624
14	MP0005645_abnormal_hypothalamus_physiol	1.98749546
15	MP0005025_abnormal_response_to	1.98595013
16	MP0001905_abnormal_dopamine_level	1.92127532
17	MP0009764_decreased_sensitivity_to	1.91840319
18	MP0002723_abnormal_immune_serum	1.90123889
19	MP0003787_abnormal_imprinting	1.85822991
20	MP0002420_abnormal_adaptive_immunity	1.84501376
21	MP0006276_abnormal_autonomic_nervous	1.83049103
22	MP0001819_abnormal_immune_cell	1.78522859
23	MP0006082_CNS_inflammation	1.72042337
24	MP0004142_abnormal_muscle_tone	1.67878651
25	MP0002277_abnormal_respiratory_mucosa	1.64691607
26	MP0002006_tumorigenesis	1.60545631
27	MP0003763_abnormal_thymus_physiology	1.59193464
28	MP0005551_abnormal_eye_electrophysiolog	1.58823900
29	MP0001986_abnormal_taste_sensitivity	1.55366362
30	MP0000685_abnormal_immune_system	1.53239970
31	MP0006072_abnormal_retinal_apoptosis	1.52382477
32	MP0000716_abnormal_immune_system	1.50628170
33	MP0002452_abnormal_antigen_presenting	1.50372723
34	MP0002933_joint_inflammation	1.48460345
35	MP0006035_abnormal_mitochondrial_morpho	1.46094275
36	MP0005253_abnormal_eye_physiology	1.44332593
37	MP0002009_preneoplasia	1.40341919
38	MP0003195_calcinosis	1.38708960
39	MP0009333_abnormal_splenocyte_physiolog	1.37071004
40	MP0001968_abnormal_touch/_nociception	1.36288202
41	MP0000689_abnormal_spleen_morphology	1.35366770
42	MP0008872_abnormal_physiological_respon	1.35232252
43	MP0002138_abnormal_hepatobiliary_system	1.35094043
44	MP0003878_abnormal_ear_physiology	1.33948053
45	MP0005377_hearing/vestibular/ear_phenot	1.33948053
46	MP0001501_abnormal_sleep_pattern	1.32692615
47	MP0002398_abnormal_bone_marrow	1.30262982
48	MP0005310_abnormal_salivary_gland	1.29104641
49	MP0003646_muscle_fatigue	1.28295075
50	MP0001919_abnormal_reproductive_system	1.26289436
51	MP0005075_abnormal_melanosome_morpholog	1.26013517
52	MP0003448_altered_tumor_morphology	1.23568839
53	MP0001873_stomach_inflammation	1.23104153
54	MP0001845_abnormal_inflammatory_respons	1.20605086
55	MP0002419_abnormal_innate_immunity	1.16549052
56	MP0004019_abnormal_vitamin_homeostasis	1.16256598
57	MP0004510_myositis	1.12937997
58	MP0003137_abnormal_impulse_conducting	1.11084658
59	MP0002722_abnormal_immune_system	1.09062710
60	MP0002405_respiratory_system_inflammati	1.08924216
61	MP0005646_abnormal_pituitary_gland	1.07193170
62	MP0008875_abnormal_xenobiotic_pharmacok	1.04657804
63	MP0002429_abnormal_blood_cell	1.03985841
64	MP0002102_abnormal_ear_morphology	1.02916744
65	MP0005464_abnormal_platelet_physiology	1.02530064
66	MP0002733_abnormal_thermal_nociception	1.02383168
67	MP0002095_abnormal_skin_pigmentation	1.02163663
68	MP0001853_heart_inflammation	1.02003799
69	MP0005423_abnormal_somatic_nervous	1.01510038
70	MP0009745_abnormal_behavioral_response	1.00556958
71	MP0002272_abnormal_nervous_system	0.99962566
72	MP0000703_abnormal_thymus_morphology	0.99834045
73	MP0001970_abnormal_pain_threshold	0.99637667
74	MP0009046_muscle_twitch	0.98384285
75	MP0008469_abnormal_protein_level	0.97698478
76	MP0004742_abnormal_vestibular_system	0.96956544
77	MP0002736_abnormal_nociception_after	0.96229341
78	MP0002693_abnormal_pancreas_physiology	0.95849185
79	MP0002876_abnormal_thyroid_physiology	0.95646483
80	MP0003724_increased_susceptibility_to	0.93549167
81	MP0000639_abnormal_adrenal_gland	0.89477180
82	MP0000230_abnormal_systemic_arterial	0.89016240
83	MP0003866_abnormal_defecation	0.88241961
84	MP0005167_abnormal_blood-brain_barrier	0.88211877
85	MP0005166_decreased_susceptibility_to	0.87963108
86	MP0002064_seizures	0.87798754
87	MP0000631_abnormal_neuroendocrine_gland	0.85809437
88	MP0000383_abnormal_hair_follicle	0.85257271
89	MP0003191_abnormal_cellular_cholesterol	0.82830732
90	MP0001502_abnormal_circadian_rhythm	0.79024996
91	MP0003075_altered_response_to	0.78536375
92	MP0001963_abnormal_hearing_physiology	0.77050633
93	MP0005389_reproductive_system_phenotype	0.75114783
94	MP0002638_abnormal_pupillary_reflex	0.74338434
95	MP0001485_abnormal_pinna_reflex	0.74025012
96	MP0002837_dystrophic_cardiac_calcinosis	0.74010009
97	MP0005084_abnormal_gallbladder_morpholo	0.73985225
98	MP0001661_extended_life_span	0.73711782
99	MP0009763_increased_sensitivity_to	0.73074975
100	MP0001764_abnormal_homeostasis	0.72866633

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatocellular necrosis (HP:0001404)	3.83748187
2	Mitochondrial inheritance (HP:0001427)	3.80314943
3	Severe combined immunodeficiency (HP:0004430)	3.79199007
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.54367332
5	Elevated erythrocyte sedimentation rate (HP:0003565)	3.45871387
6	Amyotrophic lateral sclerosis (HP:0007354)	3.36870076
7	IgG deficiency (HP:0004315)	3.32569252
8	Acute necrotizing encephalopathy (HP:0006965)	3.28763169
9	Hepatic necrosis (HP:0002605)	3.28335233
10	Increased CSF lactate (HP:0002490)	3.21892371
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.06753817
12	Pancreatic fibrosis (HP:0100732)	3.04939121
13	Thyroiditis (HP:0100646)	2.99336867
14	Increased IgM level (HP:0003496)	2.98041220
15	Hypoproteinemia (HP:0003075)	2.94032898
16	Combined immunodeficiency (HP:0005387)	2.91416075
17	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.89953166
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.89953166
19	Decreased central vision (HP:0007663)	2.88546257
20	Increased hepatocellular lipid droplets (HP:0006565)	2.88039607
21	Increased intramyocellular lipid droplets (HP:0012240)	2.78977274
22	Generalized aminoaciduria (HP:0002909)	2.76358325
23	Progressive macrocephaly (HP:0004481)	2.75799728
24	Autoimmune hemolytic anemia (HP:0001890)	2.75411636
25	Global brain atrophy (HP:0002283)	2.75070121
26	Recurrent bronchitis (HP:0002837)	2.72347228
27	Congenital stationary night blindness (HP:0007642)	2.71585873
28	Attenuation of retinal blood vessels (HP:0007843)	2.70619458
29	Lipid accumulation in hepatocytes (HP:0006561)	2.67833942
30	Pancreatic cysts (HP:0001737)	2.67386788
31	True hermaphroditism (HP:0010459)	2.64152374
32	Acute encephalopathy (HP:0006846)	2.63941295
33	Molar tooth sign on MRI (HP:0002419)	2.54421901
34	Abnormality of midbrain morphology (HP:0002418)	2.54421901
35	Abnormality of eosinophils (HP:0001879)	2.48413695
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.48381192
37	Aplastic anemia (HP:0001915)	2.45290562
38	T lymphocytopenia (HP:0005403)	2.45155297
39	Renal Fanconi syndrome (HP:0001994)	2.45083946
40	Increased muscle lipid content (HP:0009058)	2.38349235
41	Methylmalonic aciduria (HP:0012120)	2.37969944
42	Parakeratosis (HP:0001036)	2.36580870
43	Methylmalonic acidemia (HP:0002912)	2.34363358
44	Abnormality of the prostate (HP:0008775)	2.34093514
45	Encephalitis (HP:0002383)	2.30712954
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.30555917
47	Spastic paraparesis (HP:0002313)	2.29929101
48	Severe visual impairment (HP:0001141)	2.24456287
49	Abnormality of T cell number (HP:0011839)	2.24118552
50	Hyperglycinemia (HP:0002154)	2.20573010
51	Furrowed tongue (HP:0000221)	2.15855426
52	Focal motor seizures (HP:0011153)	2.15211592
53	Prostate neoplasm (HP:0100787)	2.14738699
54	Leukocytosis (HP:0001974)	2.12278490
55	Panhypogammaglobulinemia (HP:0003139)	2.09075080
56	J-shaped sella turcica (HP:0002680)	2.08860448
57	Optic disc pallor (HP:0000543)	2.08453178
58	Neuroendocrine neoplasm (HP:0100634)	2.05921978
59	Exertional dyspnea (HP:0002875)	2.05441870
60	Cerebral edema (HP:0002181)	2.05396791
61	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.02450761
62	Facial diplegia (HP:0001349)	2.01867279
63	Hematochezia (HP:0002573)	2.01214783
64	3-Methylglutaconic aciduria (HP:0003535)	2.00723212
65	Hemiplegia (HP:0002301)	2.00057702
66	Abnormality of T cells (HP:0002843)	2.00046877
67	Lymphopenia (HP:0001888)	1.99562431
68	Abnormality of the renal cortex (HP:0011035)	1.98820782
69	Ketosis (HP:0001946)	1.97601956
70	Progressive cerebellar ataxia (HP:0002073)	1.96628410
71	Congenital, generalized hypertrichosis (HP:0004540)	1.95231921
72	Abnormal drinking behavior (HP:0030082)	1.95031491
73	Polydipsia (HP:0001959)	1.95031491
74	Large for gestational age (HP:0001520)	1.93333382
75	Abnormal number of erythroid precursors (HP:0012131)	1.93181352
76	Nephronophthisis (HP:0000090)	1.91576590
77	Meningitis (HP:0001287)	1.90402555
78	Chronic sinusitis (HP:0011109)	1.89232432
79	Leukodystrophy (HP:0002415)	1.88863005
80	Myositis (HP:0100614)	1.88766971
81	Genetic anticipation (HP:0003743)	1.88686897
82	Abolished electroretinogram (ERG) (HP:0000550)	1.87170319
83	CNS demyelination (HP:0007305)	1.85389722
84	Progressive inability to walk (HP:0002505)	1.82996411
85	Eosinophilia (HP:0001880)	1.82654103
86	Ketoacidosis (HP:0001993)	1.82475384
87	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.82396033
88	Spontaneous hematomas (HP:0007420)	1.81702581
89	Renal cortical cysts (HP:0000803)	1.81469940
90	Abnormality of macular pigmentation (HP:0008002)	1.79755299
91	Palpebral edema (HP:0100540)	1.79511821
92	Episodic fever (HP:0001954)	1.79464862
93	Chronic obstructive pulmonary disease (HP:0006510)	1.74900766
94	Obstructive lung disease (HP:0006536)	1.74900766
95	Respiratory failure (HP:0002878)	1.73251903
96	Constricted visual fields (HP:0001133)	1.73207261
97	Abnormality of the intervertebral disk (HP:0005108)	1.71991547
98	Respiratory difficulties (HP:0002880)	1.70568303
99	Abnormality of the renal medulla (HP:0100957)	1.69308072
100	Microcytic anemia (HP:0001935)	1.69220445

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	5.27598781
2	TXK	4.46447978
3	TESK2	3.54112277
4	ADRBK2	3.18042414
5	ZAK	3.12612637
6	MAP3K12	2.89065659
7	FRK	2.69503547
8	MAP2K7	2.65480142
9	BCKDK	2.64973837
10	MAP4K2	2.20677218
11	MAP4K1	2.06820287
12	TRIM28	2.03729112
13	MAP3K4	1.98903838
14	WNK3	1.91610522
15	GRK1	1.89705193
16	LIMK1	1.83386167
17	TESK1	1.67024824
18	PIK3CA	1.40412965
19	SYK	1.33763033
20	VRK2	1.31646978
21	JAK3	1.31102213
22	ERBB3	1.30582608
23	MAP3K6	1.25543649
24	GRK6	1.20222655
25	TLK1	1.20104611
26	ITK	1.18353334
27	GRK7	1.17003790
28	PRKCQ	1.12265616
29	IKBKE	1.11513211
30	KIT	1.10869838
31	CAMKK2	1.07623952
32	VRK1	1.06796689
33	MAP3K11	1.02641042
34	PINK1	1.02533299
35	TAOK3	1.01144687
36	LRRK2	0.99578920
37	LYN	0.98085268
38	MAPK13	0.97983569
39	MYLK	0.97910857
40	MAPKAPK3	0.96066911
41	STK16	0.96045132
42	LCK	0.95801043
43	TNK2	0.91557541
44	CSF1R	0.91547088
45	TIE1	0.91174993
46	PIM1	0.90236318
47	MAP3K5	0.88403845
48	TEC	0.87881566
49	BUB1	0.81835750
50	MAP2K6	0.79510730
51	FES	0.79161146
52	PTK2B	0.77709805
53	FLT3	0.77388403
54	MST4	0.76410182
55	ADRBK1	0.75807207
56	BTK	0.74737268
57	NTRK2	0.73509395
58	ZAP70	0.72822381
59	WNK4	0.71091118
60	PIM2	0.68579174
61	CSK	0.67918837
62	DYRK1B	0.66141812
63	INSRR	0.64840766
64	RIPK4	0.64002795
65	PKN1	0.62148813
66	DAPK1	0.61937227
67	IRAK4	0.61675338
68	RPS6KA5	0.61153165
69	DAPK2	0.60285284
70	TYRO3	0.58808412
71	IKBKB	0.57954729
72	DYRK2	0.57046509
73	NUAK1	0.55674141
74	UHMK1	0.55670088
75	ROCK1	0.54792682
76	AKT3	0.54727988
77	MAP2K4	0.51367806
78	MAPKAPK5	0.48417810
79	OBSCN	0.48232372
80	IGF1R	0.47586882
81	CDK3	0.47228991
82	BLK	0.45691666
83	YES1	0.44552513
84	GRK5	0.44275701
85	CAMK2A	0.44244062
86	PRKACA	0.43358648
87	FYN	0.41222594
88	JAK2	0.39944567
89	PIK3CG	0.39294806
90	PRKCA	0.36271757
91	PLK2	0.33989233
92	CAMK4	0.29308657
93	ABL1	0.28365172
94	EGFR	0.28169869
95	BMPR2	0.27916059
96	PRKCE	0.27564088
97	MAPK3	0.27563030
98	CSNK2A1	0.27389114
99	CASK	0.27295605
100	CAMK1	0.26446231

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.77662361
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.69254253
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.33347574
4	Parkinsons disease_Homo sapiens_hsa05012	3.09823037
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.95023394
6	Proteasome_Homo sapiens_hsa03050	2.93311756
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.56137226
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.53104593
9	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.37375938
10	Allograft rejection_Homo sapiens_hsa05330	2.25579931
11	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.16390981
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.06517195
13	Alzheimers disease_Homo sapiens_hsa05010	2.05832838
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.05190851
15	Butanoate metabolism_Homo sapiens_hsa00650	1.96799240
16	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.89347668
17	Rheumatoid arthritis_Homo sapiens_hsa05323	1.85626463
18	Huntingtons disease_Homo sapiens_hsa05016	1.77307593
19	Antigen processing and presentation_Homo sapiens_hsa04612	1.62249413
20	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.58987230
21	Caffeine metabolism_Homo sapiens_hsa00232	1.56796130
22	Protein export_Homo sapiens_hsa03060	1.51279112
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.49936988
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48441805
25	Malaria_Homo sapiens_hsa05144	1.44990758
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.43884329
27	Asthma_Homo sapiens_hsa05310	1.39202640
28	Phototransduction_Homo sapiens_hsa04744	1.37447840
29	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.32617834
30	RNA polymerase_Homo sapiens_hsa03020	1.32386241
31	Peroxisome_Homo sapiens_hsa04146	1.28306597
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.25052132
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.23946708
34	ABC transporters_Homo sapiens_hsa02010	1.23570661
35	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.21075615
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16043695
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14751319
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13548980
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.10728730
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.09387869
41	Salmonella infection_Homo sapiens_hsa05132	1.07539887
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01520768
43	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.97119612
44	Nicotine addiction_Homo sapiens_hsa05033	0.95026173
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.92633503
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.91237064
47	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.88189824
48	Measles_Homo sapiens_hsa05162	0.85991301
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.84909483
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84507919
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.81928781
52	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.79729635
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.79602106
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78876448
55	Basal transcription factors_Homo sapiens_hsa03022	0.75137309
56	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.74606436
57	Viral myocarditis_Homo sapiens_hsa05416	0.70904224
58	Pertussis_Homo sapiens_hsa05133	0.70848481
59	Olfactory transduction_Homo sapiens_hsa04740	0.70295331
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68047523
61	Taste transduction_Homo sapiens_hsa04742	0.66826200
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64479586
63	Morphine addiction_Homo sapiens_hsa05032	0.63574437
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.63145701
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62301032
66	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.61330579
67	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60141905
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.55489729
69	Fatty acid degradation_Homo sapiens_hsa00071	0.55162857
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54870221
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52680334
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51683038
73	Retinol metabolism_Homo sapiens_hsa00830	0.49583589
74	Mineral absorption_Homo sapiens_hsa04978	0.47724797
75	Tuberculosis_Homo sapiens_hsa05152	0.47540642
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47444680
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45761012
78	Shigellosis_Homo sapiens_hsa05131	0.45183185
79	Leishmaniasis_Homo sapiens_hsa05140	0.43129776
80	Regulation of autophagy_Homo sapiens_hsa04140	0.42399443
81	Amphetamine addiction_Homo sapiens_hsa05031	0.41937313
82	TNF signaling pathway_Homo sapiens_hsa04668	0.41418307
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.40676149
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.36650650
85	Herpes simplex infection_Homo sapiens_hsa05168	0.36407178
86	Homologous recombination_Homo sapiens_hsa03440	0.35815189
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33733816
88	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.31874354
89	Metabolic pathways_Homo sapiens_hsa01100	0.31509055
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.31018666
91	Renin secretion_Homo sapiens_hsa04924	0.30619080
92	Osteoclast differentiation_Homo sapiens_hsa04380	0.30466203
93	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29851709
94	Phagosome_Homo sapiens_hsa04145	0.29564528
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28350001
96	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.28053637
97	Propanoate metabolism_Homo sapiens_hsa00640	0.27125463
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26191571
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.26080305
100	Histidine metabolism_Homo sapiens_hsa00340	0.24247743

SMARCE1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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