SMC1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.96571887
2DNA methylation involved in gamete generation (GO:0043046)9.82318322
3fusion of sperm to egg plasma membrane (GO:0007342)8.24410389
4cilium or flagellum-dependent cell motility (GO:0001539)8.11118865
5regulation of meiosis I (GO:0060631)7.99959291
6chromosome organization involved in meiosis (GO:0070192)7.79395983
7male meiosis I (GO:0007141)7.28031856
8* meiotic nuclear division (GO:0007126)7.14323229
9sperm-egg recognition (GO:0035036)6.57498717
10sperm motility (GO:0030317)6.47366809
11acrosome assembly (GO:0001675)6.36427444
12cell wall macromolecule metabolic process (GO:0044036)6.32467329
13cell wall macromolecule catabolic process (GO:0016998)6.32467329
14multicellular organism reproduction (GO:0032504)6.21762372
15binding of sperm to zona pellucida (GO:0007339)6.21351026
16plasma membrane fusion (GO:0045026)6.15977574
17meiosis I (GO:0007127)6.07355725
18spermatid development (GO:0007286)5.96007600
19cell-cell recognition (GO:0009988)5.88175174
20histone H3-K9 demethylation (GO:0033169)5.87122888
21axonemal dynein complex assembly (GO:0070286)5.74342278
22gene silencing by RNA (GO:0031047)5.61086246
23epithelial cilium movement (GO:0003351)5.52091539
24nuclear pore complex assembly (GO:0051292)5.39967274
25meiotic cell cycle process (GO:1903046)5.36874094
26nuclear pore organization (GO:0006999)5.10788689
27meiotic chromosome segregation (GO:0045132)5.09510015
28reproduction (GO:0000003)5.03089326
29motile cilium assembly (GO:0044458)4.93666606
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.82669513
31DNA alkylation (GO:0006305)4.77445885
32DNA methylation (GO:0006306)4.77445885
33cilium movement (GO:0003341)4.71952579
34histone H3-K36 demethylation (GO:0070544)4.71499912
35germ cell development (GO:0007281)4.68706964
36acrosome reaction (GO:0007340)4.67608113
37regulation of meiotic cell cycle (GO:0051445)4.67372173
38reciprocal meiotic recombination (GO:0007131)4.57611398
39reciprocal DNA recombination (GO:0035825)4.57611398
40spermatogenesis (GO:0007283)4.45714012
41male gamete generation (GO:0048232)4.45166443
42meiotic cell cycle (GO:0051321)4.39903274
43oogenesis (GO:0048477)4.39647030
44synapsis (GO:0007129)4.31979981
45microtubule depolymerization (GO:0007019)4.30112886
46negative regulation of meiosis (GO:0045835)4.25301841
47fertilization (GO:0009566)4.21930961
48cellular process involved in reproduction in multicellular organism (GO:0022412)4.17316648
49gamete generation (GO:0007276)4.16482388
50gene silencing (GO:0016458)4.14781003
51regulation of DNA endoreduplication (GO:0032875)4.13405711
52monoubiquitinated protein deubiquitination (GO:0035520)4.12149886
53pore complex assembly (GO:0046931)4.05725661
54single fertilization (GO:0007338)4.02954566
55heterochromatin organization (GO:0070828)3.92771014
56protein localization to chromosome (GO:0034502)3.89300291
57regulation of cilium movement (GO:0003352)3.88114440
58regulation of centriole replication (GO:0046599)3.87227441
59positive regulation of cellular response to oxidative stress (GO:1900409)3.84214269
60positive regulation of response to oxidative stress (GO:1902884)3.84214269
61DNA biosynthetic process (GO:0071897)3.79813273
62resolution of meiotic recombination intermediates (GO:0000712)3.79723892
63attachment of spindle microtubules to kinetochore (GO:0008608)3.78895171
64positive regulation of meiosis (GO:0045836)3.78416627
65histone exchange (GO:0043486)3.76644570
66DNA methylation or demethylation (GO:0044728)3.73199874
67negative regulation of gene silencing (GO:0060969)3.72577196
68DNA replication-dependent nucleosome organization (GO:0034723)3.71504788
69DNA replication-dependent nucleosome assembly (GO:0006335)3.71504788
70mitotic sister chromatid cohesion (GO:0007064)3.62385134
71positive regulation of meiotic cell cycle (GO:0051446)3.61178223
72DNA synthesis involved in DNA repair (GO:0000731)3.60254125
73regulation of histone H3-K9 methylation (GO:0051570)3.59377464
74protein K6-linked ubiquitination (GO:0085020)3.54795913
75histone H2A acetylation (GO:0043968)3.51419384
76* sister chromatid cohesion (GO:0007062)3.48896774
77female gamete generation (GO:0007292)3.48710581
78mitotic chromosome condensation (GO:0007076)3.44310225
79kinetochore organization (GO:0051383)3.43658180
80regulation of protein polyubiquitination (GO:1902914)3.36924331
81reproductive system development (GO:0061458)3.35475631
82sex differentiation (GO:0007548)3.34678354
83regulation of transcription from RNA polymerase I promoter (GO:0006356)3.33968147
84DNA packaging (GO:0006323)3.33553791
85sperm capacitation (GO:0048240)3.27552103
86chaperone-mediated protein complex assembly (GO:0051131)3.25383112
87negative regulation of meiotic cell cycle (GO:0051447)3.22867826
88multicellular organismal reproductive process (GO:0048609)3.22642747
89interkinetic nuclear migration (GO:0022027)3.21904648
90regulation of chromosome segregation (GO:0051983)3.18187840
91negative regulation of DNA repair (GO:0045738)3.17819418
92histone H4-K12 acetylation (GO:0043983)3.16753951
93genitalia morphogenesis (GO:0035112)3.16120811
94oocyte development (GO:0048599)3.15904583
95chromosome condensation (GO:0030261)3.14806384
96* chromosome organization (GO:0051276)3.10959016
97chromatin remodeling at centromere (GO:0031055)3.09906530
98positive regulation of translational initiation (GO:0045948)3.09396964
99DNA modification (GO:0006304)3.09379429
100ventricular system development (GO:0021591)3.08900917
101oocyte maturation (GO:0001556)3.06425294
102histone lysine demethylation (GO:0070076)3.01720409
103kinetochore assembly (GO:0051382)2.98729715
104embryonic body morphogenesis (GO:0010172)2.98303237
105DNA replication checkpoint (GO:0000076)2.97695329
106centriole replication (GO:0007099)2.96312665
107nucleus organization (GO:0006997)2.95358159
108histone demethylation (GO:0016577)2.94336217
109negative regulation of inclusion body assembly (GO:0090084)2.94069826
110regulation of meiosis (GO:0040020)2.94043507
111mitotic nuclear envelope disassembly (GO:0007077)2.92623104
112* nuclear division (GO:0000280)2.92102720
113regulation of spindle checkpoint (GO:0090231)2.90894109
114mitotic spindle assembly checkpoint (GO:0007094)2.88426585
115protein localization to chromosome, centromeric region (GO:0071459)2.88198439
116protein K11-linked deubiquitination (GO:0035871)2.87808707
117spindle assembly checkpoint (GO:0071173)2.80775908
118* organelle fission (GO:0048285)2.77439681
119regulation of microtubule-based movement (GO:0060632)2.74630267
120negative regulation of sister chromatid segregation (GO:0033046)2.71090081
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.71090081
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.71090081
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.71090081
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.71090081
125protein demethylation (GO:0006482)2.69538575
126protein dealkylation (GO:0008214)2.69538575
127positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.68580878
128mitotic spindle checkpoint (GO:0071174)2.67685529
129centriole assembly (GO:0098534)2.66352724
130negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.62311323
131negative regulation of chromosome segregation (GO:0051985)2.60078951
132protein refolding (GO:0042026)2.59979384
133proteasome assembly (GO:0043248)2.59481398
134negative regulation of nuclear division (GO:0051784)2.55784049
135negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.55196327
136regulation of sister chromatid cohesion (GO:0007063)2.53669731
137response to misfolded protein (GO:0051788)2.53431868
138piRNA metabolic process (GO:0034587)13.1814227
139synaptonemal complex assembly (GO:0007130)10.8301603
140synaptonemal complex organization (GO:0070193)10.4407447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.72934650
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.14150743
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20898688
4IGF1R_20145208_ChIP-Seq_DFB_Human3.14079738
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93774585
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81804140
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69660179
8* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.67933104
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.63490681
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.56387314
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54437686
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47495795
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35510542
14AR_21909140_ChIP-Seq_LNCAP_Human2.27324725
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25111626
16ZNF274_21170338_ChIP-Seq_K562_Hela2.22097934
17ER_23166858_ChIP-Seq_MCF-7_Human2.04635791
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03585975
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2812669
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.99744396
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99564507
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.98166847
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.92076320
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88088273
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84645054
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80416128
27VDR_22108803_ChIP-Seq_LS180_Human1.79002002
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.73119765
29* MYC_18555785_ChIP-Seq_MESCs_Mouse1.72772489
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70397304
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70071912
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68238145
33ERA_21632823_ChIP-Seq_H3396_Human1.61452241
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59467754
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58601202
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57345978
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57252247
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57000016
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53358834
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53358834
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53358834
42TP53_22573176_ChIP-Seq_HFKS_Human1.51934713
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49994971
44BCAT_22108803_ChIP-Seq_LS180_Human1.49965754
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46259735
46* RNF2_27304074_Chip-Seq_NSC_Mouse1.41847319
47AR_25329375_ChIP-Seq_VCAP_Human1.41173333
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.38590901
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36647820
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.36452465
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35919962
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33871464
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33770477
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33350561
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33019303
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32381928
57HOXB7_26014856_ChIP-Seq_BT474_Human1.31387267
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30628422
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29579231
60RUNX2_22187159_ChIP-Seq_PCA_Human1.28361028
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27779225
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.27779225
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.26545362
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25432814
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23297326
66TCF4_23295773_ChIP-Seq_U87_Human1.23279753
67GATA3_26560356_Chip-Seq_TH1_Human1.22495477
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22341222
69EWS_26573619_Chip-Seq_HEK293_Human1.22331334
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.22006306
71STAT3_23295773_ChIP-Seq_U87_Human1.21597441
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21106473
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.19267807
74TAF15_26573619_Chip-Seq_HEK293_Human1.18640165
75* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18091676
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17860156
77* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15648314
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15038877
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13465976
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11776697
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11584665
82ETV1_20927104_ChIP-Seq_GIST48_Human1.08098874
83FOXH1_21741376_ChIP-Seq_EPCs_Human1.07802792
84TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.07076268
85EZH2_22144423_ChIP-Seq_EOC_Human1.06258819
86SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05768942
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05569530
88CBP_20019798_ChIP-Seq_JUKART_Human1.05569530
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05158001
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05158001
91MYC_19829295_ChIP-Seq_ESCs_Human1.05027645
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04517901
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03898778
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03307126
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02950420
96E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01195366
97P300_19829295_ChIP-Seq_ESCs_Human1.00993541
98YY1_21170310_ChIP-Seq_MESCs_Mouse1.00017948
99STAT1_17558387_ChIP-Seq_HELA_Human0.99878081
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99583074
101MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99156870
102* YY1_22570637_ChIP-Seq_MALME-3M_Human0.98963869
103FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98335421
104WDR5_24793694_ChIP-Seq_LNCAP_Human0.97991994
105* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97945651
106GATA3_21867929_ChIP-Seq_TH1_Mouse0.97494943
107PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96980918
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.96430070
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96067716
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95854018
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95457320
112TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94715555
113PHF8_20622853_ChIP-Seq_HELA_Human0.93733197
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93653862
115XRN2_22483619_ChIP-Seq_HELA_Human0.93584793
116AR_20517297_ChIP-Seq_VCAP_Human0.93491888
117KDM5A_27292631_Chip-Seq_BREAST_Human0.93380863
118PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93047170
119* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92472813
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92368527
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92068615
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91882187
123FUS_26573619_Chip-Seq_HEK293_Human0.90776206
124* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90665706
125RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90149846
126TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89799296
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86689169
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86586413
129GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.86529785
130HTT_18923047_ChIP-ChIP_STHdh_Human0.86525341
131POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86370684
132EST1_17652178_ChIP-ChIP_JURKAT_Human0.85372247
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.85105256
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84953935
135VDR_23849224_ChIP-Seq_CD4+_Human0.84948725
136GATA3_21867929_ChIP-Seq_CD8_Mouse0.83905724
137OCT4_18555785_Chip-Seq_ESCs_Mouse0.83487830
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82719182
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82084114
140KLF4_18555785_Chip-Seq_ESCs_Mouse0.80083646
141CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79695080
142GABP_19822575_ChIP-Seq_HepG2_Human0.78869452
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78620969
144ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78613247
145FOXP3_21729870_ChIP-Seq_TREG_Human0.76301094
146TAL1_26923725_Chip-Seq_HPCs_Mouse0.76255120
147EZH2_27294783_Chip-Seq_NPCs_Mouse0.75877230
148ESRRB_18555785_Chip-Seq_ESCs_Mouse0.74812802
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.73741443
150SOX2_22085726_ChIP-Seq_NPCs_Mouse0.73232597
151DCP1A_22483619_ChIP-Seq_HELA_Human0.72872340
152STAT3_18555785_Chip-Seq_ESCs_Mouse0.72327657
153NANOG_18555785_Chip-Seq_ESCs_Mouse0.72010485
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71980809
155SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.70777155
156MYC_18940864_ChIP-ChIP_HL60_Human0.70700357
157STAT3_18555785_ChIP-Seq_MESCs_Mouse0.70491576
158TTF2_22483619_ChIP-Seq_HELA_Human0.70287584
159SOX9_26525672_Chip-Seq_HEART_Mouse0.70013517
160NFYB_21822215_ChIP-Seq_K562_Human0.69670107
161EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.68893988
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.68139618
163SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.68079293
164EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.68010896
165P300_18555785_Chip-Seq_ESCs_Mouse0.67785233

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.21983795
2MP0005410_abnormal_fertilization7.15059613
3* MP0001929_abnormal_gametogenesis4.76243905
4* MP0002210_abnormal_sex_determination4.51728151
5* MP0003698_abnormal_male_reproductive4.40236242
6MP0008057_abnormal_DNA_replication3.97262906
7MP0008995_early_reproductive_senescence3.85262617
8MP0010094_abnormal_chromosome_stability3.84870662
9* MP0001145_abnormal_male_reproductive3.68853671
10MP0008058_abnormal_DNA_repair3.42559074
11* MP0000653_abnormal_sex_gland3.32239817
12MP0003786_premature_aging3.09851636
13MP0003111_abnormal_nucleus_morphology2.86888439
14MP0000678_abnormal_parathyroid_gland2.79010448
15MP0002653_abnormal_ependyma_morphology2.64183459
16* MP0002161_abnormal_fertility/fecundity2.52612977
17MP0003693_abnormal_embryo_hatching2.42183519
18MP0003077_abnormal_cell_cycle2.34440151
19MP0004957_abnormal_blastocyst_morpholog2.20191212
20MP0003123_paternal_imprinting2.19603411
21MP0008007_abnormal_cellular_replicative2.03166408
22MP0008004_abnormal_stomach_pH1.94195967
23MP0000383_abnormal_hair_follicle1.85438877
24MP0002160_abnormal_reproductive_system1.68099509
25MP0005623_abnormal_meninges_morphology1.65709383
26MP0001730_embryonic_growth_arrest1.60638936
27MP0010307_abnormal_tumor_latency1.56167824
28MP0005174_abnormal_tail_pigmentation1.43316055
29MP0008932_abnormal_embryonic_tissue1.40444146
30* MP0001119_abnormal_female_reproductive1.37272245
31MP0008789_abnormal_olfactory_epithelium1.32876108
32MP0003890_abnormal_embryonic-extraembry1.29690043
33MP0000350_abnormal_cell_proliferation1.28512185
34MP0005647_abnormal_sex_gland1.24016257
35MP0000015_abnormal_ear_pigmentation1.23568775
36MP0003121_genomic_imprinting1.18703386
37MP0005377_hearing/vestibular/ear_phenot1.16097589
38MP0003878_abnormal_ear_physiology1.16097589
39MP0010678_abnormal_skin_adnexa1.16026747
40MP0002084_abnormal_developmental_patter1.08956683
41* MP0003699_abnormal_female_reproductive1.06732305
42MP0001672_abnormal_embryogenesis/_devel1.06386835
43MP0005380_embryogenesis_phenotype1.06386835
44MP0002085_abnormal_embryonic_tissue1.05244649
45MP0001697_abnormal_embryo_size1.04812432
46MP0004197_abnormal_fetal_growth/weight/1.02545896
47MP0005076_abnormal_cell_differentiation1.01525346
48MP0005389_reproductive_system_phenotype1.01469178
49MP0004808_abnormal_hematopoietic_stem1.00230055
50MP0002095_abnormal_skin_pigmentation0.99345863
51MP0002249_abnormal_larynx_morphology0.96441088
52MP0000013_abnormal_adipose_tissue0.92699699
53MP0003984_embryonic_growth_retardation0.92585458
54MP0000313_abnormal_cell_death0.92161939
55MP0002638_abnormal_pupillary_reflex0.91516506
56MP0003718_maternal_effect0.90708729
57MP0001293_anophthalmia0.88323026
58MP0002088_abnormal_embryonic_growth/wei0.87588228
59MP0003787_abnormal_imprinting0.86033468
60MP0004233_abnormal_muscle_weight0.85504147
61MP0009672_abnormal_birth_weight0.84699965
62MP0010352_gastrointestinal_tract_polyps0.82918364
63MP0003646_muscle_fatigue0.80967740
64MP0002080_prenatal_lethality0.80761841
65MP0003943_abnormal_hepatobiliary_system0.80283444
66MP0005409_darkened_coat_color0.79437299
67MP0005310_abnormal_salivary_gland0.78350938
68MP0001502_abnormal_circadian_rhythm0.76383138
69MP0003936_abnormal_reproductive_system0.74848597
70MP0001188_hyperpigmentation0.74366260
71MP0003315_abnormal_perineum_morphology0.74142163
72MP0002086_abnormal_extraembryonic_tissu0.73834159
73MP0002282_abnormal_trachea_morphology0.73393672
74MP0005551_abnormal_eye_electrophysiolog0.72445930
75MP0002102_abnormal_ear_morphology0.72246267
76MP0006035_abnormal_mitochondrial_morpho0.71956676
77MP0001986_abnormal_taste_sensitivity0.71225815
78MP0000427_abnormal_hair_cycle0.69303896
79MP0001984_abnormal_olfaction0.68471481
80MP0003115_abnormal_respiratory_system0.68415162
81MP0005670_abnormal_white_adipose0.66943008
82MP0002019_abnormal_tumor_incidence0.66470927
83MP0009703_decreased_birth_body0.65835438
84MP0004019_abnormal_vitamin_homeostasis0.64730740
85MP0003183_abnormal_peptide_metabolism0.63258992
86MP0005499_abnormal_olfactory_system0.63106602
87MP0005394_taste/olfaction_phenotype0.63106602
88MP0003119_abnormal_digestive_system0.63058492
89MP0003937_abnormal_limbs/digits/tail_de0.62995516
90MP0010030_abnormal_orbit_morphology0.61519151
91MP0005645_abnormal_hypothalamus_physiol0.61385027
92MP0005253_abnormal_eye_physiology0.59416850
93MP0001485_abnormal_pinna_reflex0.56829027
94MP0000631_abnormal_neuroendocrine_gland0.56709274
95MP0000647_abnormal_sebaceous_gland0.55992881
96MP0003938_abnormal_ear_development0.55058823
97MP0003861_abnormal_nervous_system0.54974373
98MP0009379_abnormal_foot_pigmentation0.51171357
99MP0002092_abnormal_eye_morphology0.49990182
100MP0000372_irregular_coat_pigmentation0.49928708
101MP0000579_abnormal_nail_morphology0.49794476
102MP0004742_abnormal_vestibular_system0.49338021
103MP0001764_abnormal_homeostasis0.48459988
104MP0001915_intracranial_hemorrhage0.48381205
105MP0000569_abnormal_digit_pigmentation0.47774262
106MP0006292_abnormal_olfactory_placode0.47646792
107MP0002971_abnormal_brown_adipose0.47638065
108MP0000432_abnormal_head_morphology0.47566193
109MP0008260_abnormal_autophagy0.46613476
110MP0000358_abnormal_cell_content/0.46371304
111MP0000778_abnormal_nervous_system0.45946364
112MP0001486_abnormal_startle_reflex0.43861242
113MP0005365_abnormal_bile_salt0.43718890
114MP0002184_abnormal_innervation0.42423264
115MP0003941_abnormal_skin_development0.41956503
116MP0000537_abnormal_urethra_morphology0.41702914
117MP0006276_abnormal_autonomic_nervous0.41213258
118MP0005391_vision/eye_phenotype0.38538225
119MP0005384_cellular_phenotype0.38436700
120MP0001963_abnormal_hearing_physiology0.37588379
121MP0005397_hematopoietic_system_phenotyp0.36562557
122MP0001545_abnormal_hematopoietic_system0.36562557
123MP0005621_abnormal_cell_physiology0.36437998
124MP0001243_abnormal_dermal_layer0.36322397
125MP0009278_abnormal_bone_marrow0.34341693
126MP0002067_abnormal_sensory_capabilities0.34177427
127MP0001727_abnormal_embryo_implantation0.33723574
128MP0001919_abnormal_reproductive_system0.33408893
129MP0002697_abnormal_eye_size0.32945035
130MP0005395_other_phenotype0.32675051
131MP0001849_ear_inflammation0.32673963
132MP0002233_abnormal_nose_morphology0.32156754
133MP0002269_muscular_atrophy0.31925791
134MP0003935_abnormal_craniofacial_develop0.29605141
135MP0002009_preneoplasia0.28085887
136MP0002114_abnormal_axial_skeleton0.27273714
137MP0003950_abnormal_plasma_membrane0.26679476
138MP0002116_abnormal_craniofacial_bone0.25141522
139MP0003755_abnormal_palate_morphology0.25132754
140MP0003567_abnormal_fetal_cardiomyocyte0.24077593
141MP0003705_abnormal_hypodermis_morpholog0.23773527
142MP0001661_extended_life_span0.22887806
143MP0005266_abnormal_metabolism0.21988458
144MP0000703_abnormal_thymus_morphology0.21809697
145MP0003632_abnormal_nervous_system0.20804505
146MP0009053_abnormal_anal_canal0.20554882
147MP0004134_abnormal_chest_morphology0.20261308

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.76547202
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.70959437
3Absent/shortened dynein arms (HP:0200106)8.70959437
4Abnormal respiratory motile cilium physiology (HP:0012261)6.55617855
5Azoospermia (HP:0000027)6.17123271
6Abnormal respiratory epithelium morphology (HP:0012253)6.00094590
7Abnormal respiratory motile cilium morphology (HP:0005938)6.00094590
8Abnormal spermatogenesis (HP:0008669)5.98919979
9Rhinitis (HP:0012384)5.65947071
10Abnormal ciliary motility (HP:0012262)5.32230156
11Chronic bronchitis (HP:0004469)5.11367676
12Gonadotropin excess (HP:0000837)4.92792791
13Abnormality of the lower motor neuron (HP:0002366)4.70899351
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.58447987
15Degeneration of the lateral corticospinal tracts (HP:0002314)4.58447987
16Infertility (HP:0000789)4.50324461
17Shoulder girdle muscle weakness (HP:0003547)4.11112366
18Nasal polyposis (HP:0100582)4.01903187
19Nephronophthisis (HP:0000090)3.63162042
20Male infertility (HP:0003251)3.60811899
21Abnormality of the corticospinal tract (HP:0002492)3.59012884
2211 pairs of ribs (HP:0000878)3.44868381
23Impulsivity (HP:0100710)3.42045968
24Rimmed vacuoles (HP:0003805)3.39199569
25Chromsome breakage (HP:0040012)3.33458222
26Horizontal nystagmus (HP:0000666)3.26123546
27Bronchiectasis (HP:0002110)3.23467355
28Supernumerary spleens (HP:0009799)3.18108337
29Abnormality of the nasal mucosa (HP:0000433)3.14329893
30Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05743551
31Amyotrophic lateral sclerosis (HP:0007354)3.03283209
32Bronchitis (HP:0012387)3.01379044
33Fibular hypoplasia (HP:0003038)2.98184321
34Abnormality of the anterior horn cell (HP:0006802)2.94049531
35Degeneration of anterior horn cells (HP:0002398)2.94049531
36Type I transferrin isoform profile (HP:0003642)2.92778289
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.88426456
38Selective tooth agenesis (HP:0001592)2.83670422
39Tubulointerstitial nephritis (HP:0001970)2.82982096
40Fair hair (HP:0002286)2.80007193
41Broad distal phalanx of finger (HP:0009836)2.78459391
42Impaired vibration sensation in the lower limbs (HP:0002166)2.75416544
43Osteomalacia (HP:0002749)2.75332734
44Abnormality of the renal medulla (HP:0100957)2.70923512
45Papillary thyroid carcinoma (HP:0002895)2.69957400
46Abnormal protein glycosylation (HP:0012346)2.69504152
47Abnormal glycosylation (HP:0012345)2.69504152
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69504152
49Abnormal protein N-linked glycosylation (HP:0012347)2.69504152
50Wrist flexion contracture (HP:0001239)2.65426240
51Hypoplastic iliac wings (HP:0002866)2.65219921
52Abnormality of DNA repair (HP:0003254)2.57217380
53Upper motor neuron abnormality (HP:0002127)2.56996174
54Abnormality of chromosome segregation (HP:0002916)2.49613863
55Ectopic kidney (HP:0000086)2.48411022
56Abnormality of the duodenum (HP:0002246)2.46522009
57Hand muscle atrophy (HP:0009130)2.43835544
58Abnormality of chromosome stability (HP:0003220)2.39667072
59Heterotopia (HP:0002282)2.31742819
60Nephroblastoma (Wilms tumor) (HP:0002667)2.28361853
61Facial hemangioma (HP:0000329)2.24729930
62Abnormality of midbrain morphology (HP:0002418)2.23170532
63Molar tooth sign on MRI (HP:0002419)2.23170532
64Metaphyseal cupping (HP:0003021)2.19422356
65Abnormality of the labia minora (HP:0012880)2.19032975
66Recurrent otitis media (HP:0000403)2.18819329
67Missing ribs (HP:0000921)2.17484725
68Abnormality of the renal collecting system (HP:0004742)2.17166670
69Lip pit (HP:0100267)2.14658902
70Facial cleft (HP:0002006)2.13370619
71Resting tremor (HP:0002322)2.11480457
72Abnormality of cochlea (HP:0000375)2.10352770
73Scotoma (HP:0000575)2.10308608
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.10077283
75Embryonal renal neoplasm (HP:0011794)2.08554067
76Aplasia/Hypoplasia of the earlobes (HP:0009906)2.08107227
77Tubular atrophy (HP:0000092)2.07968638
78Tongue fasciculations (HP:0001308)2.07585724
79Meckel diverticulum (HP:0002245)2.07152982
80Recurrent sinusitis (HP:0011108)2.06268101
81Breast carcinoma (HP:0003002)2.05995776
82Multicystic kidney dysplasia (HP:0000003)2.03282245
83Medial flaring of the eyebrow (HP:0010747)2.02931614
84Short nail (HP:0001799)2.02199233
85Microglossia (HP:0000171)2.02111558
86Aplasia/Hypoplasia of the fibula (HP:0006492)1.99611773
87Abnormality of alanine metabolism (HP:0010916)1.98699272
88Hyperalaninemia (HP:0003348)1.98699272
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98699272
90Postaxial foot polydactyly (HP:0001830)1.98453237
91Short ribs (HP:0000773)1.97877004
92Type II lissencephaly (HP:0007260)1.97579263
93Large hands (HP:0001176)1.97454723
94Non-midline cleft lip (HP:0100335)1.96803243
95Atrophy/Degeneration involving motor neurons (HP:0007373)1.95951852
96Abnormality of the ileum (HP:0001549)1.93785538
97Duplicated collecting system (HP:0000081)1.92280387
98Sloping forehead (HP:0000340)1.92068942
99Menstrual irregularities (HP:0000858)1.91629789
100Bell-shaped thorax (HP:0001591)1.90202082
101Ependymoma (HP:0002888)1.89004970
102Generalized hypopigmentation of hair (HP:0011358)1.88721277
103Abnormality of the preputium (HP:0100587)1.88538517
104Spontaneous abortion (HP:0005268)1.88048084
105Carpal bone hypoplasia (HP:0001498)1.86912000
106Sandal gap (HP:0001852)1.85984308
107Abnormality of the renal cortex (HP:0011035)1.85982182
108Small intestinal stenosis (HP:0012848)1.84857313
109Duodenal stenosis (HP:0100867)1.84857313
110Hyperpituitarism (HP:0010514)1.84556275
111Tubulointerstitial abnormality (HP:0001969)1.83059299
112Muscle fibrillation (HP:0010546)1.82347569
113Proximal placement of thumb (HP:0009623)1.81051056
114Median cleft lip (HP:0000161)1.80970657
115Widely spaced teeth (HP:0000687)1.80738998
116Oligodactyly (hands) (HP:0001180)1.80522403
117Impaired vibratory sensation (HP:0002495)1.80368837
118Medulloblastoma (HP:0002885)1.79386283
119Hypoplasia of the radius (HP:0002984)1.76194454
120Enlarged penis (HP:0000040)1.75399943
121Absent thumb (HP:0009777)1.75159172
122Increased nuchal translucency (HP:0010880)1.74098003
123Truncal obesity (HP:0001956)1.74035727
124Oligodactyly (HP:0012165)1.73167770
125Abnormality of the dental root (HP:0006486)1.70195612
126Taurodontia (HP:0000679)1.70195612
127Abnormality of permanent molar morphology (HP:0011071)1.70195612
128Stage 5 chronic kidney disease (HP:0003774)1.69883918
129Embryonal neoplasm (HP:0002898)1.69073328
130Abnormal lung lobation (HP:0002101)1.68784938
131Male pseudohermaphroditism (HP:0000037)1.66969204
132Urinary bladder sphincter dysfunction (HP:0002839)1.66782365
133Abnormality of the carotid arteries (HP:0005344)1.65756900
134Severe visual impairment (HP:0001141)1.64668427
135Volvulus (HP:0002580)1.62878910
136Poor coordination (HP:0002370)1.62821507
137Shawl scrotum (HP:0000049)1.62398311
138Clitoromegaly (HP:0000057)1.62393209
139Spastic gait (HP:0002064)1.62038648
140Absent radius (HP:0003974)1.61933248
141Recurrent bronchitis (HP:0002837)1.61386622
142Impaired proprioception (HP:0010831)1.60431239
143Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59442854
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57549662
145Abnormality of the astrocytes (HP:0100707)1.56540837
146Astrocytoma (HP:0009592)1.56540837
147Renovascular hypertension (HP:0100817)1.56079977
148Renal dysplasia (HP:0000110)1.54344071
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.53298342
150Short thumb (HP:0009778)1.53074832
151Absent forearm bone (HP:0003953)1.52434814
152Aplasia involving forearm bones (HP:0009822)1.52434814
153Prominent nose (HP:0000448)1.52310610
154Rhabdomyosarcoma (HP:0002859)1.51138413
155Oculomotor apraxia (HP:0000657)1.49924726
156Capillary hemangiomas (HP:0005306)1.49819319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.16662505
2PDK47.16662505
3CDK195.07128993
4PDK24.55466649
5CDC74.26521518
6CDK123.95097696
7ACVR1B3.05750935
8NEK22.90577712
9WEE12.80983275
10OXSR12.57947890
11INSRR2.16931734
12NEK92.11663901
13PNCK2.10025411
14TTK2.07839618
15TESK12.06317473
16PRKD32.03687375
17ICK1.80997234
18BMX1.77219116
19BRSK21.75935774
20CSF1R1.71821892
21PLK41.69133486
22PLK11.67955458
23STK38L1.66427231
24FGR1.52234872
25ATR1.50875863
26CHEK21.42828424
27CHEK11.40420995
28PTK2B1.35999955
29STK31.32992997
30BRD41.21738807
31ATM1.13921111
32TYRO31.09539972
33WNK41.07780719
34PDGFRB1.06983440
35RET1.06644166
36NEK11.04421839
37CDK71.03620044
38PLK30.97310064
39NUAK10.97165225
40SRPK10.95814508
41PASK0.94817435
42BRSK10.90896867
43STK390.89655126
44DYRK30.87054408
45MAP3K20.86456160
46ZAK0.85887883
47MKNK20.85442188
48CDK40.82057541
49MAP3K40.81115415
50BUB10.81004608
51CCNB10.79474189
52MAP2K20.76949581
53NEK60.75287901
54PBK0.74416342
55MELK0.74107302
56AURKB0.73229436
57CDK20.71007449
58PDPK10.70256786
59WNK30.69695376
60WNK10.67292359
61STK240.66735756
62MKNK10.66683017
63AKT30.65977410
64TLK10.65624088
65EIF2AK10.65010014
66STK160.64224277
67STK380.63964073
68MAPK130.63887978
69EGFR0.63098872
70CDK10.63072325
71MTOR0.63012469
72MST1R0.59607803
73EEF2K0.59445520
74STK110.54570829
75SGK10.53069082
76CDK90.52954394
77LATS10.52081908
78STK40.51060970
79AURKA0.49337212
80ARAF0.47682885
81MAP3K100.43574270
82MAP3K130.43433350
83PRKDC0.41800962
84LMTK20.41629173
85CASK0.40778438
86CSNK1D0.39527558
87MARK30.39079628
88MAP3K60.38295696
89IRAK20.38014162
90CDK60.37648616
91PLK20.36784557
92CSNK2A20.36369721
93CAMK10.35933069
94BMPR1B0.35893965
95PDK10.34452574
96GSK3B0.33174700
97BRAF0.32807744
98KSR10.32689055
99DYRK1B0.32482234
100CSNK1E0.31278719
101CSNK2A10.29918207
102NTRK30.28474494
103PINK10.28068467
104FRK0.27955888
105LATS20.26750058
106IGF1R0.26278510
107MAPK140.25434161
108CAMK1G0.25149663
109PAK10.24787729
110MUSK0.24651404
111TNK20.24625820
112CDK11A0.23669394
113RPS6KA10.23577010
114PAK40.23551484
115MAP4K20.23453769
116PTK20.22876036
117RPS6KB10.22582619
118MAPK80.22548252
119TGFBR10.22039449
120NLK0.20364016
121IRAK10.20237929
122TSSK60.20018803
123CAMK1D0.19229228
124PRKG10.19195346
125CDC42BPA0.18984993
126MAP3K80.18451634
127MAPK100.17536051
128MAPK10.17452123
129CDK30.17446075
130KSR20.17218120
131PRKAA10.16525126
132MAPK110.16341536
133CDK80.15354302
134PRKACB0.14922900
135PIM10.12967281
136RPS6KB20.12670648
137AKT10.12012570
138EIF2AK30.11814860
139VRK10.11026160
140DYRK1A0.10649107
141STK100.10503423
142CLK10.10371990
143MET0.09469399
144PRKCI0.09414935

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.71161147
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.28458219
3Fanconi anemia pathway_Homo sapiens_hsa034603.87093505
4Homologous recombination_Homo sapiens_hsa034403.83878838
5RNA transport_Homo sapiens_hsa030133.44187830
6DNA replication_Homo sapiens_hsa030303.42858579
7Mismatch repair_Homo sapiens_hsa034303.37621518
8mRNA surveillance pathway_Homo sapiens_hsa030153.01961464
9* Cell cycle_Homo sapiens_hsa041102.80996381
10Sulfur relay system_Homo sapiens_hsa041222.70664799
11Regulation of autophagy_Homo sapiens_hsa041402.68941791
12Spliceosome_Homo sapiens_hsa030402.46130194
13Selenocompound metabolism_Homo sapiens_hsa004502.45192868
14Nucleotide excision repair_Homo sapiens_hsa034202.40214222
15Vitamin B6 metabolism_Homo sapiens_hsa007502.28811312
16Non-homologous end-joining_Homo sapiens_hsa034502.25056618
17* Oocyte meiosis_Homo sapiens_hsa041142.19842688
18Dorso-ventral axis formation_Homo sapiens_hsa043202.13241051
19RNA degradation_Homo sapiens_hsa030182.08428658
20Base excision repair_Homo sapiens_hsa034102.01590049
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.99938388
22RNA polymerase_Homo sapiens_hsa030201.82660833
23Pyruvate metabolism_Homo sapiens_hsa006201.80051633
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.61476390
25Pentose phosphate pathway_Homo sapiens_hsa000301.52643156
26One carbon pool by folate_Homo sapiens_hsa006701.48569931
27Pyrimidine metabolism_Homo sapiens_hsa002401.47844305
28Proteasome_Homo sapiens_hsa030501.41994124
29p53 signaling pathway_Homo sapiens_hsa041151.40821966
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38619854
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35255174
32Purine metabolism_Homo sapiens_hsa002301.29473129
33Retinol metabolism_Homo sapiens_hsa008301.15100124
34Glucagon signaling pathway_Homo sapiens_hsa049221.14839845
35Fatty acid biosynthesis_Homo sapiens_hsa000611.09359815
36beta-Alanine metabolism_Homo sapiens_hsa004101.08519437
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.07180466
38Linoleic acid metabolism_Homo sapiens_hsa005911.06754370
39Huntingtons disease_Homo sapiens_hsa050161.06034860
40Circadian rhythm_Homo sapiens_hsa047101.05618183
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02575340
42Lysine degradation_Homo sapiens_hsa003101.02543477
43Propanoate metabolism_Homo sapiens_hsa006401.02472647
44Antigen processing and presentation_Homo sapiens_hsa046120.98969013
45Phototransduction_Homo sapiens_hsa047440.98180469
46Epstein-Barr virus infection_Homo sapiens_hsa051690.97978630
47Herpes simplex infection_Homo sapiens_hsa051680.96785307
48N-Glycan biosynthesis_Homo sapiens_hsa005100.96375577
49Glycerolipid metabolism_Homo sapiens_hsa005610.95675286
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86218662
51mTOR signaling pathway_Homo sapiens_hsa041500.85230533
52Olfactory transduction_Homo sapiens_hsa047400.82759714
53Viral carcinogenesis_Homo sapiens_hsa052030.79933004
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79044058
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.77920382
56Biosynthesis of amino acids_Homo sapiens_hsa012300.77295180
57HTLV-I infection_Homo sapiens_hsa051660.76483080
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74493635
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70926358
60Systemic lupus erythematosus_Homo sapiens_hsa053220.68872515
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67929745
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67709000
63TGF-beta signaling pathway_Homo sapiens_hsa043500.67195861
64ABC transporters_Homo sapiens_hsa020100.63423800
65Calcium signaling pathway_Homo sapiens_hsa040200.61421397
66Carbon metabolism_Homo sapiens_hsa012000.61118846
67Phenylalanine metabolism_Homo sapiens_hsa003600.57771699
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56838194
69Type II diabetes mellitus_Homo sapiens_hsa049300.55678636
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55264517
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.54632305
72Nitrogen metabolism_Homo sapiens_hsa009100.54423734
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54174926
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52938109
75Butanoate metabolism_Homo sapiens_hsa006500.50971841
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.50110270
77Parkinsons disease_Homo sapiens_hsa050120.50091946
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49727068
79Hedgehog signaling pathway_Homo sapiens_hsa043400.49452674
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.48156240
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.47507871
82Adherens junction_Homo sapiens_hsa045200.46915997
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.45634791
84Influenza A_Homo sapiens_hsa051640.45195233
85Hippo signaling pathway_Homo sapiens_hsa043900.44330139
86ErbB signaling pathway_Homo sapiens_hsa040120.42911303
87Glutathione metabolism_Homo sapiens_hsa004800.42487675
88Basal cell carcinoma_Homo sapiens_hsa052170.42256538
89Fatty acid degradation_Homo sapiens_hsa000710.41430064
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40578016
91Notch signaling pathway_Homo sapiens_hsa043300.39545842
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38897712
93Tight junction_Homo sapiens_hsa045300.38754553
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.38004416
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36827638
96Choline metabolism in cancer_Homo sapiens_hsa052310.35512298
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.35227018
98Wnt signaling pathway_Homo sapiens_hsa043100.33976976
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33800152
100Ether lipid metabolism_Homo sapiens_hsa005650.33536191
101Taste transduction_Homo sapiens_hsa047420.33183737
102Peroxisome_Homo sapiens_hsa041460.31474820
103Thyroid cancer_Homo sapiens_hsa052160.31445087
104MicroRNAs in cancer_Homo sapiens_hsa052060.29956050
105Small cell lung cancer_Homo sapiens_hsa052220.28459606
106Inositol phosphate metabolism_Homo sapiens_hsa005620.28405397
107Arachidonic acid metabolism_Homo sapiens_hsa005900.27742983
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25274517
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25227739
110Ovarian steroidogenesis_Homo sapiens_hsa049130.24538026
111Alcoholism_Homo sapiens_hsa050340.23506919
112Tyrosine metabolism_Homo sapiens_hsa003500.22151113
113Mineral absorption_Homo sapiens_hsa049780.21327264
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20232407
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18065564
116Estrogen signaling pathway_Homo sapiens_hsa049150.17810406
117MAPK signaling pathway_Homo sapiens_hsa040100.17554574
118Fat digestion and absorption_Homo sapiens_hsa049750.17262271
119Amphetamine addiction_Homo sapiens_hsa050310.16358261
120PPAR signaling pathway_Homo sapiens_hsa033200.14959388
121VEGF signaling pathway_Homo sapiens_hsa043700.14822506
122Renin-angiotensin system_Homo sapiens_hsa046140.14218611
123AMPK signaling pathway_Homo sapiens_hsa041520.13901735
124Protein export_Homo sapiens_hsa030600.13805016
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.13525964
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13037577
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12209698
128Nicotine addiction_Homo sapiens_hsa050330.11464106
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10391877
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.09335001
131Metabolic pathways_Homo sapiens_hsa011000.09116305
132Melanoma_Homo sapiens_hsa052180.09062970
133Tryptophan metabolism_Homo sapiens_hsa003800.08776350
134Legionellosis_Homo sapiens_hsa051340.08656412
135Fructose and mannose metabolism_Homo sapiens_hsa000510.08021470
136Pathways in cancer_Homo sapiens_hsa052000.06452757
137Prostate cancer_Homo sapiens_hsa052150.06111996
138Long-term potentiation_Homo sapiens_hsa047200.05064202
139HIF-1 signaling pathway_Homo sapiens_hsa040660.04917713
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.04362697
141Protein digestion and absorption_Homo sapiens_hsa049740.03503436
142Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.03351341
143Vitamin digestion and absorption_Homo sapiens_hsa049770.03168426
144Fatty acid metabolism_Homo sapiens_hsa012120.02899615

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