SMC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.68709483
2DNA unwinding involved in DNA replication (GO:0006268)5.30286215
3* kinetochore organization (GO:0051383)4.99357337
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.95948424
5nuclear pore organization (GO:0006999)4.93570408
6nuclear pore complex assembly (GO:0051292)4.92079194
7sister chromatid segregation (GO:0000819)4.91809160
8protein localization to chromosome, centromeric region (GO:0071459)4.89225725
9mitotic sister chromatid segregation (GO:0000070)4.88395878
10CENP-A containing nucleosome assembly (GO:0034080)4.85416345
11chromatin remodeling at centromere (GO:0031055)4.81524065
12mitotic metaphase plate congression (GO:0007080)4.79181311
13DNA strand elongation involved in DNA replication (GO:0006271)4.73116021
14attachment of spindle microtubules to kinetochore (GO:0008608)4.69596963
15* mitotic chromosome condensation (GO:0007076)4.64092685
16DNA replication initiation (GO:0006270)4.61596067
17kinetochore assembly (GO:0051382)4.53681065
18metaphase plate congression (GO:0051310)4.51386229
19telomere maintenance via semi-conservative replication (GO:0032201)4.51101024
20DNA strand elongation (GO:0022616)4.49084466
21mitotic sister chromatid cohesion (GO:0007064)4.48529711
22DNA replication-independent nucleosome organization (GO:0034724)4.41769996
23DNA replication-independent nucleosome assembly (GO:0006336)4.41769996
24mitotic recombination (GO:0006312)4.41562476
25establishment of integrated proviral latency (GO:0075713)4.37697871
26telomere maintenance via recombination (GO:0000722)4.25306432
27DNA replication-dependent nucleosome assembly (GO:0006335)4.19823971
28DNA replication-dependent nucleosome organization (GO:0034723)4.19823971
29establishment of chromosome localization (GO:0051303)4.18882157
30mitotic nuclear envelope disassembly (GO:0007077)4.18230541
31DNA topological change (GO:0006265)4.11442587
32DNA replication checkpoint (GO:0000076)4.10226166
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.08474381
34regulation of spindle organization (GO:0090224)4.08334699
35histone exchange (GO:0043486)4.06686631
36membrane disassembly (GO:0030397)3.89221720
37nuclear envelope disassembly (GO:0051081)3.89221720
38spindle checkpoint (GO:0031577)3.79173688
39pore complex assembly (GO:0046931)3.78581448
40DNA double-strand break processing (GO:0000729)3.76421873
41telomere maintenance via telomere lengthening (GO:0010833)3.72942607
42non-recombinational repair (GO:0000726)3.71379094
43double-strand break repair via nonhomologous end joining (GO:0006303)3.71379094
44regulation of mitotic spindle organization (GO:0060236)3.70164812
45DNA geometric change (GO:0032392)3.70031022
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.68757349
47DNA duplex unwinding (GO:0032508)3.68026521
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.66115939
49positive regulation of chromosome segregation (GO:0051984)3.65294572
50chromatin assembly or disassembly (GO:0006333)3.63716548
51protein localization to chromosome (GO:0034502)3.62508526
52regulation of chromosome segregation (GO:0051983)3.62079691
53* chromosome segregation (GO:0007059)3.61470400
54spindle assembly checkpoint (GO:0071173)3.61212495
55regulation of DNA endoreduplication (GO:0032875)3.58594084
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55423067
57regulation of centrosome cycle (GO:0046605)3.54713251
58IMP biosynthetic process (GO:0006188)3.53441021
59negative regulation of chromosome segregation (GO:0051985)3.51936498
60replication fork processing (GO:0031297)3.51786994
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.51056412
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.51056412
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.51056412
64negative regulation of sister chromatid segregation (GO:0033046)3.51056412
65regulation of centriole replication (GO:0046599)3.50314565
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.48721484
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48721484
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48721484
69* meiotic chromosome segregation (GO:0045132)3.48711959
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.46822787
71regulation of sister chromatid cohesion (GO:0007063)3.44923468
72mitotic spindle assembly checkpoint (GO:0007094)3.43299729
73mitotic spindle checkpoint (GO:0071174)3.41875089
74mitotic G2/M transition checkpoint (GO:0044818)3.41494209
75regulation of histone H3-K9 methylation (GO:0051570)3.40962848
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.40055069
77ATP-dependent chromatin remodeling (GO:0043044)3.39736766
78centriole replication (GO:0007099)3.39216996
79regulation of sister chromatid segregation (GO:0033045)3.38199862
80regulation of mitotic sister chromatid separation (GO:0010965)3.38199862
81regulation of mitotic sister chromatid segregation (GO:0033047)3.38199862
82* DNA conformation change (GO:0071103)3.29561978
83nucleobase biosynthetic process (GO:0046112)3.29310556
84* chromosome condensation (GO:0030261)3.28023714
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.25832704
86resolution of meiotic recombination intermediates (GO:0000712)3.25144290
87DNA ligation (GO:0006266)3.23788107
88telomere maintenance (GO:0000723)3.18662764
89spindle assembly involved in mitosis (GO:0090307)3.17233938
90establishment of viral latency (GO:0019043)3.17142353
91telomere organization (GO:0032200)3.16571224
92ribosomal small subunit assembly (GO:0000028)3.15282310
93mitotic spindle organization (GO:0007052)3.14927568
94protein K6-linked ubiquitination (GO:0085020)3.13968242
95maturation of SSU-rRNA (GO:0030490)3.13798225
96microtubule depolymerization (GO:0007019)3.13057987
97folic acid-containing compound biosynthetic process (GO:0009396)3.12115596
98formation of translation preinitiation complex (GO:0001731)3.11661677
99negative regulation of DNA-dependent DNA replication (GO:2000104)3.10916223
100translesion synthesis (GO:0019985)3.10663236
101IMP metabolic process (GO:0046040)3.08657998
102somatic hypermutation of immunoglobulin genes (GO:0016446)3.07946692
103somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07946692
104heterochromatin organization (GO:0070828)3.05920413
105* mitotic cell cycle (GO:0000278)3.04610994
106sister chromatid cohesion (GO:0007062)3.04162298
107regulation of centrosome duplication (GO:0010824)3.03972764
108negative regulation of mitosis (GO:0045839)3.03830339
109mismatch repair (GO:0006298)3.03618944
110* DNA packaging (GO:0006323)3.02423239
111histone-serine phosphorylation (GO:0035404)3.01975370
112DNA catabolic process, exonucleolytic (GO:0000738)3.01884388
113regulation of double-strand break repair via homologous recombination (GO:0010569)3.00265817
114postreplication repair (GO:0006301)2.99871492
115negative regulation of histone methylation (GO:0031061)2.98677955
116purine nucleobase biosynthetic process (GO:0009113)2.96559805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.57736011
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.99421596
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.11780787
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.72178535
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00901965
6AR_21909140_ChIP-Seq_LNCAP_Human2.78379063
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64658860
8* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61223660
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.58651328
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56047630
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.51573139
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44639978
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.40476425
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31335198
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27857572
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22551604
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20887799
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18766094
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06153319
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05699724
21* XRN2_22483619_ChIP-Seq_HELA_Human2.01649065
22E2F7_22180533_ChIP-Seq_HELA_Human11.3526098
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98857116
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.98247263
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.94425316
26* VDR_23849224_ChIP-Seq_CD4+_Human1.87113743
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83164114
28ELK1_19687146_ChIP-ChIP_HELA_Human1.82579278
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80521518
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78247550
31FOXP3_21729870_ChIP-Seq_TREG_Human1.72430569
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69812848
33TTF2_22483619_ChIP-Seq_HELA_Human1.66584289
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66257269
35DCP1A_22483619_ChIP-Seq_HELA_Human1.64477269
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61214256
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60843920
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59930093
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.59513098
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.56282260
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53435138
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50745188
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50721889
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50419506
45CIITA_25753668_ChIP-Seq_RAJI_Human1.45634240
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45456331
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45303935
48MYC_22102868_ChIP-Seq_BL_Human1.43372388
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36891124
50GABP_19822575_ChIP-Seq_HepG2_Human1.36571945
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36561552
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34854092
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34212977
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32177186
55KDM5A_27292631_Chip-Seq_BREAST_Human1.31982480
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31495995
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30847318
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28061522
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25093145
60EWS_26573619_Chip-Seq_HEK293_Human1.23836686
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22246996
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20004331
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18599910
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13664259
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12177872
66FUS_26573619_Chip-Seq_HEK293_Human1.10036382
67* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08675273
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03502652
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03007334
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02647306
71POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99621227
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98379625
73TFEB_21752829_ChIP-Seq_HELA_Human0.97866677
74STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97428546
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97088937
76MYC_18940864_ChIP-ChIP_HL60_Human0.96482247
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95699246
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94404603
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91353277
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90966724
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88740199
82NANOG_21062744_ChIP-ChIP_HESCs_Human0.88230004
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87989547
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87025405
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85614539
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85500558
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.85498173
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84663305
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83937818
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83917016
91* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83260945
92VDR_21846776_ChIP-Seq_THP-1_Human0.81779471
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.78406797
94SPI1_23547873_ChIP-Seq_NB4_Human0.78237348
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78155922
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75487957
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.74927719
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.73981868
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72127540
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71995102
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71506946
102SOX17_20123909_ChIP-Seq_XEN_Mouse0.69798259
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69050611
104CHD1_26751641_Chip-Seq_LNCaP_Human0.66777769
105IRF1_19129219_ChIP-ChIP_H3396_Human0.66726908
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.65288363
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64451905
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.64396663
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.64316520
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.64073220
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.63636735
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.62859924
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.62844026
114SOX9_26525672_Chip-Seq_HEART_Mouse0.59863773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.99435837
2MP0010094_abnormal_chromosome_stability4.95832838
3MP0003111_abnormal_nucleus_morphology4.43966456
4MP0008057_abnormal_DNA_replication4.27316544
5MP0004957_abnormal_blastocyst_morpholog4.05557838
6MP0003077_abnormal_cell_cycle4.05026732
7MP0008058_abnormal_DNA_repair3.06416145
8MP0008007_abnormal_cellular_replicative2.80186162
9MP0003123_paternal_imprinting2.66603392
10MP0008932_abnormal_embryonic_tissue2.61715480
11MP0010307_abnormal_tumor_latency2.30863528
12MP0002396_abnormal_hematopoietic_system2.27082990
13MP0000350_abnormal_cell_proliferation2.25572895
14MP0001730_embryonic_growth_arrest2.25152316
15MP0010352_gastrointestinal_tract_polyps2.21345618
16MP0008877_abnormal_DNA_methylation2.21303559
17MP0003121_genomic_imprinting1.94568386
18MP0001672_abnormal_embryogenesis/_devel1.78912102
19MP0005380_embryogenesis_phenotype1.78912102
20MP0001697_abnormal_embryo_size1.77170372
21MP0004808_abnormal_hematopoietic_stem1.73638912
22MP0005076_abnormal_cell_differentiation1.69619210
23MP0004197_abnormal_fetal_growth/weight/1.63976799
24MP0003786_premature_aging1.63835374
25MP0003984_embryonic_growth_retardation1.61954471
26MP0002085_abnormal_embryonic_tissue1.59230923
27MP0002088_abnormal_embryonic_growth/wei1.59160916
28MP0003567_abnormal_fetal_cardiomyocyte1.59103281
29MP0000490_abnormal_crypts_of1.55349232
30MP0002080_prenatal_lethality1.52166944
31MP0002084_abnormal_developmental_patter1.51032842
32MP0002086_abnormal_extraembryonic_tissu1.50451316
33MP0006054_spinal_hemorrhage1.48617148
34MP0010030_abnormal_orbit_morphology1.45819186
35MP0003890_abnormal_embryonic-extraembry1.43608146
36MP0000313_abnormal_cell_death1.37880208
37MP0002019_abnormal_tumor_incidence1.31560531
38MP0009053_abnormal_anal_canal1.30015006
39MP0001293_anophthalmia1.25872758
40MP0003315_abnormal_perineum_morphology1.25415994
41MP0002009_preneoplasia1.24100187
42MP0003705_abnormal_hypodermis_morpholog1.20956673
43MP0002210_abnormal_sex_determination1.14952696
44MP0003937_abnormal_limbs/digits/tail_de1.13341112
45MP0000703_abnormal_thymus_morphology1.11442591
46MP0002877_abnormal_melanocyte_morpholog1.11097395
47MP0003941_abnormal_skin_development1.08660261
48MP0008789_abnormal_olfactory_epithelium1.06409935
49MP0002234_abnormal_pharynx_morphology1.05915533
50MP0006072_abnormal_retinal_apoptosis1.02346453
51MP0000537_abnormal_urethra_morphology1.01998281
52MP0001545_abnormal_hematopoietic_system1.01491013
53MP0005397_hematopoietic_system_phenotyp1.01491013
54MP0001145_abnormal_male_reproductive1.00586177
55MP0002398_abnormal_bone_marrow0.96796515
56MP0004147_increased_porphyrin_level0.94116480
57MP0009703_decreased_birth_body0.92705925
58MP0002233_abnormal_nose_morphology0.91225675
59MP0001346_abnormal_lacrimal_gland0.91043294
60MP0009672_abnormal_birth_weight0.90658178
61MP0001915_intracranial_hemorrhage0.88737818
62MP0002722_abnormal_immune_system0.88314042
63MP0003763_abnormal_thymus_physiology0.86246059
64MP0002111_abnormal_tail_morphology0.85680717
65MP0000358_abnormal_cell_content/0.85561622
66MP0000653_abnormal_sex_gland0.84751616
67MP0002938_white_spotting0.84664705
68MP0001929_abnormal_gametogenesis0.84531599
69MP0003787_abnormal_imprinting0.83337731
70MP0009379_abnormal_foot_pigmentation0.82248697
71MP0009278_abnormal_bone_marrow0.80925996
72MP0009333_abnormal_splenocyte_physiolog0.79960421
73MP0006035_abnormal_mitochondrial_morpho0.79942077
74MP0001119_abnormal_female_reproductive0.79721912
75MP0000689_abnormal_spleen_morphology0.79662150
76MP0003718_maternal_effect0.79215758
77MP0003566_abnormal_cell_adhesion0.78613921
78MP0001286_abnormal_eye_development0.78605810
79MP0005394_taste/olfaction_phenotype0.78177583
80MP0005499_abnormal_olfactory_system0.78177583
81MP0000647_abnormal_sebaceous_gland0.77114611
82MP0002092_abnormal_eye_morphology0.76529719
83MP0003119_abnormal_digestive_system0.76296722
84MP0003950_abnormal_plasma_membrane0.75537329
85MP0003699_abnormal_female_reproductive0.74554641
86MP0010234_abnormal_vibrissa_follicle0.74391985
87MP0003806_abnormal_nucleotide_metabolis0.74153729
88MP0000428_abnormal_craniofacial_morphol0.73820388
89MP0000432_abnormal_head_morphology0.73458936
90MP0005023_abnormal_wound_healing0.72314111
91MP0003698_abnormal_male_reproductive0.72128832
92MP0003115_abnormal_respiratory_system0.72089602
93MP0005395_other_phenotype0.71929330
94MP0002697_abnormal_eye_size0.69550560
95MP0000858_altered_metastatic_potential0.69253146
96MP0002095_abnormal_skin_pigmentation0.68653607
97MP0002925_abnormal_cardiovascular_devel0.68455711
98MP0005384_cellular_phenotype0.68440834
99MP0002429_abnormal_blood_cell0.68349447
100MP0003935_abnormal_craniofacial_develop0.67314206
101MP0000733_abnormal_muscle_development0.66928662
102MP0005501_abnormal_skin_physiology0.66355052
103MP0009697_abnormal_copulation0.66024885
104MP0005621_abnormal_cell_physiology0.65972863
105MP0001529_abnormal_vocalization0.65532358
106MP0002161_abnormal_fertility/fecundity0.65173548
107MP0000372_irregular_coat_pigmentation0.64678599
108MP0000569_abnormal_digit_pigmentation0.64206912
109MP0005391_vision/eye_phenotype0.63336539
110MP0003755_abnormal_palate_morphology0.62937410
111MP0000566_synostosis0.62018280
112MP0000049_abnormal_middle_ear0.61240392
113MP0005389_reproductive_system_phenotype0.60444997
114MP0002160_abnormal_reproductive_system0.60034339
115MP0002006_tumorigenesis0.60011315
116MP0010678_abnormal_skin_adnexa0.59362341
117MP0002177_abnormal_outer_ear0.59269185
118MP0002932_abnormal_joint_morphology0.59074867
119MP0003136_yellow_coat_color0.58743791
120MP0003448_altered_tumor_morphology0.56904700
121MP0005408_hypopigmentation0.56015662
122MP0001849_ear_inflammation0.55433618
123MP0000477_abnormal_intestine_morphology0.55280542
124MP0003385_abnormal_body_wall0.54964315
125MP0003861_abnormal_nervous_system0.54946018
126MP0002114_abnormal_axial_skeleton0.54722440
127MP0006292_abnormal_olfactory_placode0.54611965
128MP0000716_abnormal_immune_system0.54434062
129MP0005367_renal/urinary_system_phenotyp0.53033896
130MP0000516_abnormal_urinary_system0.53033896
131MP0003943_abnormal_hepatobiliary_system0.52966860

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.60139709
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.18146049
3Birth length less than 3rd percentile (HP:0003561)3.83137625
4Abnormality of chromosome stability (HP:0003220)3.78696260
5Volvulus (HP:0002580)3.75735783
6Reticulocytopenia (HP:0001896)3.54743301
7Colon cancer (HP:0003003)3.45184166
8Meckel diverticulum (HP:0002245)3.24718924
9Medulloblastoma (HP:0002885)3.18890684
10Increased nuchal translucency (HP:0010880)3.18382380
11Abnormality of the preputium (HP:0100587)3.12175542
12Selective tooth agenesis (HP:0001592)3.07604399
13Abnormality of the ileum (HP:0001549)3.06288395
14Patellar aplasia (HP:0006443)3.05650879
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.01805010
16Small intestinal stenosis (HP:0012848)2.98877741
17Duodenal stenosis (HP:0100867)2.98877741
18Ectopic kidney (HP:0000086)2.96923830
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.95288940
20Short 4th metacarpal (HP:0010044)2.95288940
21Abnormal lung lobation (HP:0002101)2.94222834
22Ependymoma (HP:0002888)2.89721333
23Cortical dysplasia (HP:0002539)2.86152269
24Proximal placement of thumb (HP:0009623)2.82971934
25Myelodysplasia (HP:0002863)2.82338665
26Aplasia/Hypoplasia of the patella (HP:0006498)2.82219802
27Breast hypoplasia (HP:0003187)2.81953663
28Deviation of the thumb (HP:0009603)2.79471830
29Impulsivity (HP:0100710)2.78218249
30Nephroblastoma (Wilms tumor) (HP:0002667)2.76975038
31Absent radius (HP:0003974)2.70924204
32Agnosia (HP:0010524)2.62661105
33Embryonal renal neoplasm (HP:0011794)2.61896409
34Abnormality of the labia minora (HP:0012880)2.60209225
35Rhabdomyosarcoma (HP:0002859)2.52199279
36Aplasia involving forearm bones (HP:0009822)2.52005251
37Absent forearm bone (HP:0003953)2.52005251
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51228042
3911 pairs of ribs (HP:0000878)2.51141353
40Abnormal number of incisors (HP:0011064)2.50562995
41Abnormality of the duodenum (HP:0002246)2.48604429
42Sloping forehead (HP:0000340)2.43286545
43Absent thumb (HP:0009777)2.43139765
44Atresia of the external auditory canal (HP:0000413)2.35892636
45Overlapping toe (HP:0001845)2.35784636
46Supernumerary spleens (HP:0009799)2.30659726
47Abnormality of the anterior horn cell (HP:0006802)2.28970397
48Degeneration of anterior horn cells (HP:0002398)2.28970397
49Oral leukoplakia (HP:0002745)2.28749348
50Abnormality of the carotid arteries (HP:0005344)2.28120392
51High pitched voice (HP:0001620)2.25355643
52Duplicated collecting system (HP:0000081)2.23607902
53Facial hemangioma (HP:0000329)2.23133525
54Abnormality of cells of the erythroid lineage (HP:0012130)2.21836802
55Cafe-au-lait spot (HP:0000957)2.21028875
56Carpal bone hypoplasia (HP:0001498)2.20578574
57Basal cell carcinoma (HP:0002671)2.17311415
58Embryonal neoplasm (HP:0002898)2.17155753
59Bone marrow hypocellularity (HP:0005528)2.15412666
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.15061700
61Choanal atresia (HP:0000453)2.11468553
62Neoplasm of the pancreas (HP:0002894)2.11161589
63Short thumb (HP:0009778)2.08445116
64Abnormal number of erythroid precursors (HP:0012131)2.08082729
65Missing ribs (HP:0000921)2.07447368
66Deep philtrum (HP:0002002)2.05781995
67Astrocytoma (HP:0009592)2.05529235
68Abnormality of the astrocytes (HP:0100707)2.05529235
69Horseshoe kidney (HP:0000085)2.03392844
70Prominent nose (HP:0000448)2.02009239
71Abnormality of the renal collecting system (HP:0004742)2.01282494
72Triphalangeal thumb (HP:0001199)2.01143064
73Tracheoesophageal fistula (HP:0002575)2.00382167
74Premature graying of hair (HP:0002216)2.00206948
75Abnormality of the 4th metacarpal (HP:0010012)1.99746470
76Aplastic anemia (HP:0001915)1.99065472
77Glioma (HP:0009733)1.98200573
78Squamous cell carcinoma (HP:0002860)1.96688581
79Clubbing of toes (HP:0100760)1.94240997
80Neoplasm of the oral cavity (HP:0100649)1.93953741
81Neoplasm of the colon (HP:0100273)1.92631836
82Biliary tract neoplasm (HP:0100574)1.92361283
83Duplication of thumb phalanx (HP:0009942)1.92073122
84Ovarian neoplasm (HP:0100615)1.88830176
85Long eyelashes (HP:0000527)1.88080644
86Amaurosis fugax (HP:0100576)1.83832461
87Neoplasm of striated muscle (HP:0009728)1.83551916
88Abnormality of the calcaneus (HP:0008364)1.80339682
89Lymphoma (HP:0002665)1.78223275
90Cellular immunodeficiency (HP:0005374)1.77524859
91Pallor (HP:0000980)1.77469948
92High anterior hairline (HP:0009890)1.77175297
93Cutaneous melanoma (HP:0012056)1.76404859
94Abnormality of DNA repair (HP:0003254)1.76315714
95Increased hepatocellular lipid droplets (HP:0006565)1.75888091
96Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75841439
97Oligodactyly (hands) (HP:0001180)1.75462157
98Skull defect (HP:0001362)1.74864372
99Abdominal situs inversus (HP:0003363)1.74444859
100Abnormality of abdominal situs (HP:0011620)1.74444859
101Multiple enchondromatosis (HP:0005701)1.74410934
102Microvesicular hepatic steatosis (HP:0001414)1.73122939
103Acute myeloid leukemia (HP:0004808)1.72980575
104Gastrointestinal carcinoma (HP:0002672)1.72599285
105Malignant gastrointestinal tract tumors (HP:0006749)1.72599285
106Abnormality of cochlea (HP:0000375)1.72358870
107Arteriovenous malformation (HP:0100026)1.70696823
108Microtia (HP:0008551)1.69849006
109Abnormality of chromosome segregation (HP:0002916)1.69112314
110Short middle phalanx of the 5th finger (HP:0004220)1.68618772
111Acute necrotizing encephalopathy (HP:0006965)1.66168659
112Small hand (HP:0200055)1.65680040
113Renal duplication (HP:0000075)1.65539148
114Abnormality of the septum pellucidum (HP:0007375)1.65273521
115Sandal gap (HP:0001852)1.64674273
116Single umbilical artery (HP:0001195)1.64583376
117Abnormality of the fetal cardiovascular system (HP:0010948)1.64583376
118Abnormal umbilical cord blood vessels (HP:0011403)1.64583376
119Microglossia (HP:0000171)1.63056878
120Oligodactyly (HP:0012165)1.60107395
121Macrocytic anemia (HP:0001972)1.59619664
122Facial cleft (HP:0002006)1.58906421
123Hypoplastic pelvis (HP:0008839)1.58685754
124Acute encephalopathy (HP:0006846)1.57357831
125Abnormality of methionine metabolism (HP:0010901)1.55372473
126Absent septum pellucidum (HP:0001331)1.53299457
127Median cleft lip (HP:0000161)1.52812907
128Aplasia/Hypoplasia of the earlobes (HP:0009906)1.52393472
129Abnormal mitochondria in muscle tissue (HP:0008316)1.50601093
130Abnormal auditory evoked potentials (HP:0006958)1.50206722
131Abnormality of glycolysis (HP:0004366)1.48862541
132Increased serum pyruvate (HP:0003542)1.48291928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.19272688
2WEE14.15187477
3BUB14.00480923
4NEK23.24079296
5EIF2AK12.91277959
6TTK2.79784645
7SRPK12.73506982
8NEK12.58921348
9BRSK22.54026226
10VRK22.28504515
11CDK122.23822168
12MKNK12.22188821
13PLK12.19469938
14AURKB2.11390790
15PLK42.03675094
16PLK31.95172710
17ATR1.94102923
18TAF11.90919759
19ACVR1B1.78987061
20STK41.69480468
21PASK1.67881327
22TLK11.67252348
23BRSK11.64298761
24VRK11.64166525
25STK101.60361741
26TSSK61.59458540
27CHEK21.59250104
28CCNB11.57843339
29MKNK21.56228520
30CDK71.54969173
31MAP3K81.49623659
32CDK41.47181257
33EIF2AK31.44708888
34ZAK1.44321201
35CHEK11.42534962
36RPS6KA41.37494117
37RPS6KB21.35569087
38MELK1.27921764
39DYRK31.25260368
40CDK61.21186039
41ATM1.19122459
42TESK21.17899803
43CLK11.17513237
44BRD41.17453996
45EEF2K1.17251837
46TGFBR11.16620268
47AURKA1.12358209
48PBK1.06757868
49NME21.01969273
50TRIM280.99357863
51STK30.97733886
52SCYL20.97125519
53CDK20.94695898
54MAP3K100.91368681
55EIF2AK20.89579880
56PAK40.89431534
57PIM10.87013036
58CDK10.85389085
59PKN20.83226201
60BMPR1B0.72764057
61PLK20.70813924
62BRAF0.70627227
63ALK0.67092892
64CDK30.66416699
65TNIK0.64512440
66NME10.62089338
67LRRK20.61154310
68RPS6KA50.60107222
69CSNK2A20.60027882
70STK390.58578104
71CSNK2A10.58011058
72CDK80.57322822
73SMG10.57213559
74STK38L0.56773914
75ERBB40.55567810
76STK160.54719957
77ERBB30.53030070
78FLT30.52088011
79PNCK0.50727792
80EPHA20.50040518
81NUAK10.49407148
82PRKDC0.48718472
83MET0.47284163
84YES10.45720250
85LATS10.45409306
86MAP4K10.44961883
87TTN0.42698239
88TESK10.42694536
89PAK10.42551615
90TRPM70.41126149
91LATS20.38774500
92NEK90.38448380
93MARK30.38117576
94CSNK1D0.35742613
95MAPK140.35736354
96BCR0.35067140
97CDK180.34602338
98MTOR0.34077887
99FGFR10.33118909
100CDK150.32665005
101CDK11A0.32505839
102PDK20.31046585
103PAK20.30400216
104AKT10.29973453
105CDK140.29705709
106MST40.28550857
107CDK90.28306705
108CSNK1E0.28052975
109MST1R0.28039734
110AKT20.27590097
111MINK10.27303249
112TEC0.27026126
113CSNK1G10.25995061
114BTK0.25956365
115CSF1R0.22580110
116STK240.20980347
117WNK30.20951284
118GSK3B0.20873721
119MAPK10.20078846
120RPS6KB10.19391470
121CAMK1G0.18668238
122PRKCI0.18626263
123DYRK1B0.17519448
124MAP2K30.17259192
125RPS6KC10.16298537
126RPS6KL10.16298537
127RAF10.15913292

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.24048319
2Mismatch repair_Homo sapiens_hsa034304.60978647
3Cell cycle_Homo sapiens_hsa041103.36646379
4Homologous recombination_Homo sapiens_hsa034403.35434514
5Spliceosome_Homo sapiens_hsa030403.31154907
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19651924
7RNA transport_Homo sapiens_hsa030133.06120639
8Base excision repair_Homo sapiens_hsa034103.06014505
9Nucleotide excision repair_Homo sapiens_hsa034202.96537220
10Fanconi anemia pathway_Homo sapiens_hsa034602.72296740
11One carbon pool by folate_Homo sapiens_hsa006702.64504786
12Non-homologous end-joining_Homo sapiens_hsa034502.59630728
13Ribosome_Homo sapiens_hsa030102.51441083
14RNA polymerase_Homo sapiens_hsa030202.19583289
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17246088
16Proteasome_Homo sapiens_hsa030502.15305084
17Systemic lupus erythematosus_Homo sapiens_hsa053222.10829053
18Pyrimidine metabolism_Homo sapiens_hsa002402.00503982
19RNA degradation_Homo sapiens_hsa030182.00049858
20mRNA surveillance pathway_Homo sapiens_hsa030151.99492966
21p53 signaling pathway_Homo sapiens_hsa041151.80933856
22Basal transcription factors_Homo sapiens_hsa030221.73665439
23Viral carcinogenesis_Homo sapiens_hsa052031.34794767
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31607293
25Oocyte meiosis_Homo sapiens_hsa041141.28010996
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24156983
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.19779054
28Pyruvate metabolism_Homo sapiens_hsa006201.17955182
29Epstein-Barr virus infection_Homo sapiens_hsa051691.17213748
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14392191
31Folate biosynthesis_Homo sapiens_hsa007901.09354530
32MicroRNAs in cancer_Homo sapiens_hsa052061.08717459
33Herpes simplex infection_Homo sapiens_hsa051681.08709256
34Antigen processing and presentation_Homo sapiens_hsa046121.04083740
35HTLV-I infection_Homo sapiens_hsa051661.00660067
36Purine metabolism_Homo sapiens_hsa002300.99366540
37Small cell lung cancer_Homo sapiens_hsa052220.96076846
38Propanoate metabolism_Homo sapiens_hsa006400.93832591
39Alcoholism_Homo sapiens_hsa050340.91892377
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88740407
41Parkinsons disease_Homo sapiens_hsa050120.88259048
42Huntingtons disease_Homo sapiens_hsa050160.88114446
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87940486
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87034482
45Steroid biosynthesis_Homo sapiens_hsa001000.86049496
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85041156
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82952566
48Oxidative phosphorylation_Homo sapiens_hsa001900.81259464
49Vitamin B6 metabolism_Homo sapiens_hsa007500.79407191
50Carbon metabolism_Homo sapiens_hsa012000.76895509
51Thyroid cancer_Homo sapiens_hsa052160.73797219
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69825958
53TGF-beta signaling pathway_Homo sapiens_hsa043500.66485524
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66129476
55Fatty acid elongation_Homo sapiens_hsa000620.63628503
56Primary immunodeficiency_Homo sapiens_hsa053400.62901551
57Colorectal cancer_Homo sapiens_hsa052100.61183717
58Hepatitis B_Homo sapiens_hsa051610.58889836
59Chronic myeloid leukemia_Homo sapiens_hsa052200.58444487
60Basal cell carcinoma_Homo sapiens_hsa052170.57613901
61Hippo signaling pathway_Homo sapiens_hsa043900.57334850
62Legionellosis_Homo sapiens_hsa051340.56450632
63Selenocompound metabolism_Homo sapiens_hsa004500.55792816
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55715026
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55312039
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54691984
67Viral myocarditis_Homo sapiens_hsa054160.54427333
68Adherens junction_Homo sapiens_hsa045200.53623488
69Apoptosis_Homo sapiens_hsa042100.53490255
70Measles_Homo sapiens_hsa051620.53101269
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52656803
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49404322
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49192369
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.48012071
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45250088
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44911721
77Prostate cancer_Homo sapiens_hsa052150.43104063
78Alzheimers disease_Homo sapiens_hsa050100.42830096
79Pathways in cancer_Homo sapiens_hsa052000.42297261
80Hematopoietic cell lineage_Homo sapiens_hsa046400.41978821
81Shigellosis_Homo sapiens_hsa051310.41536834
82Notch signaling pathway_Homo sapiens_hsa043300.39880776
83Lysine degradation_Homo sapiens_hsa003100.38095386
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37711975
85Non-small cell lung cancer_Homo sapiens_hsa052230.36720998
86Bladder cancer_Homo sapiens_hsa052190.35055641
87Pentose phosphate pathway_Homo sapiens_hsa000300.33741509
88Pancreatic cancer_Homo sapiens_hsa052120.33521915
89Metabolic pathways_Homo sapiens_hsa011000.33487820
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32167889
91Influenza A_Homo sapiens_hsa051640.32067160
92HIF-1 signaling pathway_Homo sapiens_hsa040660.31933158
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.31418082
94Protein export_Homo sapiens_hsa030600.31359165
95Biosynthesis of amino acids_Homo sapiens_hsa012300.30670119
96Proteoglycans in cancer_Homo sapiens_hsa052050.30107112
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.29846324
98N-Glycan biosynthesis_Homo sapiens_hsa005100.29584585
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28910544
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28109521
101FoxO signaling pathway_Homo sapiens_hsa040680.27457718
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.26990640
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.26906738
104Hedgehog signaling pathway_Homo sapiens_hsa043400.26636591
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.26172120
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23449496
107Melanoma_Homo sapiens_hsa052180.23296313
108Wnt signaling pathway_Homo sapiens_hsa043100.23043333
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.22894379
110Glutathione metabolism_Homo sapiens_hsa004800.22482251
111Leishmaniasis_Homo sapiens_hsa051400.21113517
112Fatty acid metabolism_Homo sapiens_hsa012120.20609747
113mTOR signaling pathway_Homo sapiens_hsa041500.20144395
114Asthma_Homo sapiens_hsa053100.19921532
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19883389
116Tight junction_Homo sapiens_hsa045300.19149046
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19073949
118Sulfur relay system_Homo sapiens_hsa041220.18671931
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17815860
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16063969
121Autoimmune thyroid disease_Homo sapiens_hsa053200.15943756
122B cell receptor signaling pathway_Homo sapiens_hsa046620.15555566
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15108271
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15081272
125T cell receptor signaling pathway_Homo sapiens_hsa046600.14593809
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14507609
127Endometrial cancer_Homo sapiens_hsa052130.14338884
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13956138
129Renin-angiotensin system_Homo sapiens_hsa046140.13936233
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12022514
131Butanoate metabolism_Homo sapiens_hsa006500.10037908
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.04704433
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.00217403
134Glioma_Homo sapiens_hsa05214-0.0135551

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