SMC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)6.22494767
2nuclear pore complex assembly (GO:0051292)6.11192537
3mitotic sister chromatid cohesion (GO:0007064)5.79203446
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.24172289
5pore complex assembly (GO:0046931)4.83376858
6centriole replication (GO:0007099)4.80168954
7protein localization to kinetochore (GO:0034501)4.60756100
8DNA double-strand break processing (GO:0000729)4.52369439
9replication fork processing (GO:0031297)4.36381278
10regulation of centriole replication (GO:0046599)4.31972510
11kinetochore organization (GO:0051383)4.27299222
12protein localization to chromosome, centromeric region (GO:0071459)4.07392579
13DNA unwinding involved in DNA replication (GO:0006268)4.07367488
14regulation of RNA export from nucleus (GO:0046831)4.06532046
15mitotic metaphase plate congression (GO:0007080)4.06062083
16interkinetic nuclear migration (GO:0022027)4.01892432
17sister chromatid segregation (GO:0000819)4.00976311
18mitotic chromosome condensation (GO:0007076)3.99843585
19mitotic nuclear envelope disassembly (GO:0007077)3.98342466
20pre-miRNA processing (GO:0031054)3.94785765
21rRNA catabolic process (GO:0016075)3.88460972
22regulation of histone H3-K9 methylation (GO:0051570)3.85029396
23metaphase plate congression (GO:0051310)3.80297601
24regulation of DNA endoreduplication (GO:0032875)3.78550486
25membrane disassembly (GO:0030397)3.76797590
26nuclear envelope disassembly (GO:0051081)3.76797590
27attachment of spindle microtubules to kinetochore (GO:0008608)3.76557221
28DNA replication-dependent nucleosome assembly (GO:0006335)3.76099081
29DNA replication-dependent nucleosome organization (GO:0034723)3.76099081
30* non-recombinational repair (GO:0000726)3.75869708
31* double-strand break repair via nonhomologous end joining (GO:0006303)3.75869708
32maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.73623885
33mitotic sister chromatid segregation (GO:0000070)3.73200802
34regulation of spindle organization (GO:0090224)3.69753213
35chromatin remodeling at centromere (GO:0031055)3.67729274
36positive regulation of histone H3-K4 methylation (GO:0051571)3.65783371
37negative regulation of DNA repair (GO:0045738)3.65457061
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.63272914
39CENP-A containing nucleosome assembly (GO:0034080)3.61135267
40histone exchange (GO:0043486)3.58409024
41meiotic chromosome segregation (GO:0045132)3.57389377
42DNA replication initiation (GO:0006270)3.56430335
43regulation of centrosome cycle (GO:0046605)3.53936204
44DNA geometric change (GO:0032392)3.53641236
45DNA duplex unwinding (GO:0032508)3.51580897
46regulation of mitotic spindle organization (GO:0060236)3.51217030
47DNA replication-independent nucleosome assembly (GO:0006336)3.48889326
48DNA replication-independent nucleosome organization (GO:0034724)3.48889326
49sister chromatid cohesion (GO:0007062)3.47646530
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.46149069
51monoubiquitinated protein deubiquitination (GO:0035520)3.43227302
52chromatin assembly (GO:0031497)3.39494523
53peptidyl-lysine trimethylation (GO:0018023)3.39020536
54negative regulation of histone methylation (GO:0031061)3.37458958
55response to UV-C (GO:0010225)3.33796428
56definitive hemopoiesis (GO:0060216)3.33344382
57* positive regulation of mitotic sister chromatid separation (GO:1901970)3.31917609
58* positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31917609
59* positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31917609
60heterochromatin organization (GO:0070828)3.31752157
61translesion synthesis (GO:0019985)3.31394157
62microtubule depolymerization (GO:0007019)3.31147697
63DNA-dependent DNA replication (GO:0006261)3.30943473
64kinetochore assembly (GO:0051382)3.29886192
65chromatin assembly or disassembly (GO:0006333)3.29811188
66* double-strand break repair via homologous recombination (GO:0000724)3.29526329
67* recombinational repair (GO:0000725)3.29270081
68establishment of chromosome localization (GO:0051303)3.29145008
69spindle checkpoint (GO:0031577)3.28571630
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.25830343
71somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.25830343
72isotype switching (GO:0045190)3.25830343
73chromosome condensation (GO:0030261)3.25653012
74* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23291469
75* regulation of chromosome segregation (GO:0051983)3.23270420
76regulation of centrosome duplication (GO:0010824)3.22349595
77centrosome duplication (GO:0051298)3.22000245
78regulation of pigment cell differentiation (GO:0050932)3.20429500
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19667081
80protein localization to chromosome (GO:0034502)3.18214320
81histone H3-K9 methylation (GO:0051567)3.16621052
82gene silencing by RNA (GO:0031047)3.16593521
83DNA conformation change (GO:0071103)3.16471324
84protein K6-linked ubiquitination (GO:0085020)3.16431130
85DNA strand elongation involved in DNA replication (GO:0006271)3.15678552
86DNA packaging (GO:0006323)3.15413969
87spindle assembly checkpoint (GO:0071173)3.14674319
88centriole assembly (GO:0098534)3.14496233
89histone mRNA catabolic process (GO:0071044)3.14264620
90* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14157476
91centrosome organization (GO:0051297)3.14030817
92regulation of nucleobase-containing compound transport (GO:0032239)3.13990866
93regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.13954920
94positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.13954920
95negative regulation of chromosome segregation (GO:0051985)3.13363222
96synaptonemal complex assembly (GO:0007130)3.13096749
97ATP-dependent chromatin remodeling (GO:0043044)3.12479172
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12466778
99negative regulation of sister chromatid segregation (GO:0033046)3.12466778
100negative regulation of mitotic sister chromatid separation (GO:2000816)3.12466778
101negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12466778
102somatic recombination of immunoglobulin gene segments (GO:0016447)3.12424712
103mitotic spindle checkpoint (GO:0071174)3.11962501
104negative regulation of DNA-dependent DNA replication (GO:2000104)3.11111479
105microtubule anchoring (GO:0034453)3.10524179
106ncRNA catabolic process (GO:0034661)3.08950227
107DNA replication checkpoint (GO:0000076)3.07908447
108response to X-ray (GO:0010165)3.07886143
109somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.07733416
110somatic cell DNA recombination (GO:0016444)3.07733416
111* regulation of mitotic sister chromatid separation (GO:0010965)3.06349589
112* regulation of mitotic sister chromatid segregation (GO:0033047)3.06349589
113* regulation of sister chromatid segregation (GO:0033045)3.06349589
114microtubule organizing center organization (GO:0031023)3.05817777
115* positive regulation of chromosome segregation (GO:0051984)3.05046505
116mitotic spindle assembly checkpoint (GO:0007094)3.04135360
117regulation of helicase activity (GO:0051095)3.03606706
118* mitotic recombination (GO:0006312)3.03329613
119histone-serine phosphorylation (GO:0035404)3.01908521
120chromosome segregation (GO:0007059)3.01657714
121mitotic G2/M transition checkpoint (GO:0044818)3.01535715
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01233336
123DNA ligation (GO:0006266)3.00691217
124cilium or flagellum-dependent cell motility (GO:0001539)2.99109659
125DNA strand elongation (GO:0022616)2.98271283
126positive regulation of granulocyte differentiation (GO:0030854)2.97950173
127chromosome organization involved in meiosis (GO:0070192)2.97451813
128phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.95985655
129DNA topological change (GO:0006265)2.95046029
130postreplication repair (GO:0006301)2.93026510
131replicative senescence (GO:0090399)2.92854806
132mRNA stabilization (GO:0048255)2.91456972
133RNA stabilization (GO:0043489)2.91456972
134ribosome assembly (GO:0042255)2.90920496
135synaptonemal complex organization (GO:0070193)2.90857279
136mitotic G2 DNA damage checkpoint (GO:0007095)2.90841004
137male meiosis (GO:0007140)2.90623124
138regulation of fibroblast apoptotic process (GO:2000269)2.89847676
139dosage compensation (GO:0007549)2.89807951
140somatic diversification of immune receptors (GO:0002200)2.89684448
141nuclear envelope organization (GO:0006998)2.87315614
142somatic diversification of immunoglobulins (GO:0016445)2.86892530
143telomere maintenance via semi-conservative replication (GO:0032201)2.86529054
144reciprocal DNA recombination (GO:0035825)2.86294323
145reciprocal meiotic recombination (GO:0007131)2.86294323
146histone H3-K4 trimethylation (GO:0080182)2.84580936
147* telomere maintenance via recombination (GO:0000722)2.84416214
148mRNA transport (GO:0051028)2.83951486
149mitochondrial DNA replication (GO:0006264)2.83736005
150neural tube formation (GO:0001841)2.83111954
151snRNA transcription (GO:0009301)2.82489155
152regulation of DNA damage checkpoint (GO:2000001)2.81860604
153prenylation (GO:0097354)2.80870796
154protein prenylation (GO:0018342)2.80870796
155* double-strand break repair (GO:0006302)2.79722769
156regulation of chromatin silencing (GO:0031935)2.78824781
157peptidyl-lysine methylation (GO:0018022)2.77921770
158establishment of protein localization to Golgi (GO:0072600)2.77487194
159V(D)J recombination (GO:0033151)2.77015794
160transcription from mitochondrial promoter (GO:0006390)2.76110882
161negative regulation of DNA recombination (GO:0045910)2.72427258
162spermatid nucleus differentiation (GO:0007289)2.70987040
163cytoplasmic mRNA processing body assembly (GO:0033962)2.68682107
164resolution of meiotic recombination intermediates (GO:0000712)2.66800786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.97761506
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.87694380
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.92253132
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.55537056
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.53676881
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.48647286
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.40657464
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.86999930
9AR_21909140_ChIP-Seq_LNCAP_Human2.73600607
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.69670172
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.67220522
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38947566
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26010633
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.18511189
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17864195
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.17385824
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06924086
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05496970
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05319745
20IGF1R_20145208_ChIP-Seq_DFB_Human2.02328454
21* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00020668
22E2F7_22180533_ChIP-Seq_HELA_Human10.8932238
23YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96219081
24ELK1_19687146_ChIP-ChIP_HELA_Human1.90661342
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88147490
26TAF15_26573619_Chip-Seq_HEK293_Human1.86191087
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78521466
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78404031
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77035914
30ZNF274_21170338_ChIP-Seq_K562_Hela1.72238887
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71693972
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70085695
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66751963
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64606032
35VDR_23849224_ChIP-Seq_CD4+_Human1.58705546
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58058608
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57139160
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.52444134
39* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52162290
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.48843328
41CIITA_25753668_ChIP-Seq_RAJI_Human1.47388863
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46802279
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46695673
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46055955
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44442894
46XRN2_22483619_ChIP-Seq_HELA_Human1.44329917
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41624635
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.40788730
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40200045
50* P300_19829295_ChIP-Seq_ESCs_Human1.40042592
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39109281
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38862003
53IRF1_19129219_ChIP-ChIP_H3396_Human1.38791456
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38608895
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37299955
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36452484
57ER_23166858_ChIP-Seq_MCF-7_Human1.36200457
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35527991
59KDM5A_27292631_Chip-Seq_BREAST_Human1.35323727
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34431606
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34299277
62FOXP3_21729870_ChIP-Seq_TREG_Human1.33895259
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32819860
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32242334
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32183868
66MYC_22102868_ChIP-Seq_BL_Human1.32047050
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31358776
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.30095838
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28476259
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27619188
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25118177
72STAT3_23295773_ChIP-Seq_U87_Human1.23356864
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.23339617
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21333449
75GATA1_22025678_ChIP-Seq_K562_Human1.20047818
76TTF2_22483619_ChIP-Seq_HELA_Human1.19472495
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17864098
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17356345
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16895188
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16267751
81* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15876468
82* CBP_20019798_ChIP-Seq_JUKART_Human1.15876468
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15695161
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15484082
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14883817
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14877531
87TCF4_23295773_ChIP-Seq_U87_Human1.14804444
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.14716077
89* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13764805
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13701686
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13489298
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12822116
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11801837
94MYC_18940864_ChIP-ChIP_HL60_Human1.11387163
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.10998684
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09938160
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08869502
98VDR_22108803_ChIP-Seq_LS180_Human1.08642611
99SMAD4_21799915_ChIP-Seq_A2780_Human1.08317175
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07275143
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.06938850
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06916692
103GBX2_23144817_ChIP-Seq_PC3_Human1.06627255
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05725408
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05723199
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.05668950
107P53_22387025_ChIP-Seq_ESCs_Mouse1.05430186
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05375157
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05089960
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05074701
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.05041025
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04664129
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.04277188
114STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03615773
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.02723033
116P300_18555785_Chip-Seq_ESCs_Mouse1.01237360
117TFEB_21752829_ChIP-Seq_HELA_Human1.01103856
118* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00509226
119DCP1A_22483619_ChIP-Seq_HELA_Human1.00155794
120OCT4_18555785_Chip-Seq_ESCs_Mouse0.99904749
121TP53_16413492_ChIP-PET_HCT116_Human0.99759358
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99391890
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98229642
124EWS_26573619_Chip-Seq_HEK293_Human0.98042380
125CDX2_22108803_ChIP-Seq_LS180_Human0.97580627
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.96709507
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.96643538
128GABP_17652178_ChIP-ChIP_JURKAT_Human0.95851199
129GABP_19822575_ChIP-Seq_HepG2_Human0.95741948
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95713386
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95605162
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95312883
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92345936
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90875313
135FUS_26573619_Chip-Seq_HEK293_Human0.90516561
136MYB_26560356_Chip-Seq_TH1_Human0.89351436
137SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88852787
138HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88313916
139* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87112901
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86220832
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85901389
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85901389
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85901389
144STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85324295
145BRD4_25478319_ChIP-Seq_HGPS_Human0.83363153
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81308717
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81242472
148CHD1_26751641_Chip-Seq_LNCaP_Human0.80253921
149ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78929574
150SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78906926
151SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.78692823
152ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78260099
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77968464
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74760354
155NANOG_16153702_ChIP-ChIP_HESCs_Human0.73826322
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73230387
157MYB_26560356_Chip-Seq_TH2_Human0.72799118
158THAP11_20581084_ChIP-Seq_MESCs_Mouse0.72194717
159ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.71158372
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70066241
161SOX17_20123909_ChIP-Seq_XEN_Mouse0.69504050
162POU5F1_16153702_ChIP-ChIP_HESCs_Human0.69414705
163ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.69345252
164GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68150662
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67878730
166CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.66994822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.15605840
2MP0010094_abnormal_chromosome_stability3.97640775
3MP0000569_abnormal_digit_pigmentation3.85627263
4MP0003111_abnormal_nucleus_morphology3.43183957
5MP0003693_abnormal_embryo_hatching3.36750254
6MP0003077_abnormal_cell_cycle3.25157499
7MP0008877_abnormal_DNA_methylation3.22314527
8MP0004957_abnormal_blastocyst_morpholog3.13932002
9MP0010307_abnormal_tumor_latency2.72013185
10MP0008058_abnormal_DNA_repair2.66671756
11MP0008007_abnormal_cellular_replicative2.55042821
12MP0010352_gastrointestinal_tract_polyps2.37670912
13MP0003763_abnormal_thymus_physiology2.34865342
14MP0003121_genomic_imprinting2.08988897
15MP0001730_embryonic_growth_arrest2.04073845
16MP0003123_paternal_imprinting2.02659420
17MP0005076_abnormal_cell_differentiation2.01617158
18MP0004808_abnormal_hematopoietic_stem2.00975482
19MP0008932_abnormal_embryonic_tissue1.96870673
20MP0000350_abnormal_cell_proliferation1.96386432
21MP0004197_abnormal_fetal_growth/weight/1.85989126
22MP0001672_abnormal_embryogenesis/_devel1.76541574
23MP0005380_embryogenesis_phenotype1.76541574
24MP0002084_abnormal_developmental_patter1.72747396
25MP0001293_anophthalmia1.69687128
26MP0002210_abnormal_sex_determination1.65375933
27MP0003984_embryonic_growth_retardation1.64454597
28MP0002088_abnormal_embryonic_growth/wei1.63258939
29MP0005410_abnormal_fertilization1.62433340
30MP0001697_abnormal_embryo_size1.60854171
31MP0001929_abnormal_gametogenesis1.59986770
32MP0002085_abnormal_embryonic_tissue1.57600038
33MP0002086_abnormal_extraembryonic_tissu1.55302769
34MP0002396_abnormal_hematopoietic_system1.53327366
35MP0003705_abnormal_hypodermis_morpholog1.51890641
36MP0003567_abnormal_fetal_cardiomyocyte1.50853466
37MP0003890_abnormal_embryonic-extraembry1.50797311
38MP0000383_abnormal_hair_follicle1.49620167
39MP0005174_abnormal_tail_pigmentation1.49218882
40MP0003937_abnormal_limbs/digits/tail_de1.48550075
41MP0010030_abnormal_orbit_morphology1.45935557
42MP0003786_premature_aging1.45636425
43MP0003787_abnormal_imprinting1.36456871
44MP0002080_prenatal_lethality1.36152512
45MP0001145_abnormal_male_reproductive1.35244308
46MP0006072_abnormal_retinal_apoptosis1.33171477
47MP0000428_abnormal_craniofacial_morphol1.32926299
48MP0003698_abnormal_male_reproductive1.31899339
49MP0005623_abnormal_meninges_morphology1.31800939
50MP0000733_abnormal_muscle_development1.30922549
51MP0001835_abnormal_antigen_presentation1.30643536
52MP0000015_abnormal_ear_pigmentation1.28569434
53MP0003950_abnormal_plasma_membrane1.27082661
54MP0003656_abnormal_erythrocyte_physiolo1.26941453
55MP0002234_abnormal_pharynx_morphology1.22480942
56MP0006292_abnormal_olfactory_placode1.21993377
57MP0009703_decreased_birth_body1.19949526
58MP0009278_abnormal_bone_marrow1.18810177
59MP0004134_abnormal_chest_morphology1.16161173
60MP0000653_abnormal_sex_gland1.15182096
61MP0005075_abnormal_melanosome_morpholog1.13107669
62MP0002092_abnormal_eye_morphology1.13103283
63MP0000313_abnormal_cell_death1.11907529
64MP0003252_abnormal_bile_duct1.11052820
65MP0010678_abnormal_skin_adnexa1.10968735
66MP0009053_abnormal_anal_canal1.07709270
67MP0006054_spinal_hemorrhage1.05981548
68MP0000432_abnormal_head_morphology1.05192468
69MP0002697_abnormal_eye_size1.04175283
70MP0008875_abnormal_xenobiotic_pharmacok1.01439597
71MP0003566_abnormal_cell_adhesion1.01172097
72MP0000703_abnormal_thymus_morphology1.01154796
73MP0001188_hyperpigmentation1.00790779
74MP0009672_abnormal_birth_weight0.99751629
75MP0002019_abnormal_tumor_incidence0.99537220
76MP0003935_abnormal_craniofacial_develop0.99248946
77MP0001915_intracranial_hemorrhage0.96736783
78MP0003115_abnormal_respiratory_system0.96348946
79MP0000689_abnormal_spleen_morphology0.96310403
80MP0003943_abnormal_hepatobiliary_system0.95150635
81MP0003718_maternal_effect0.94480429
82MP0001545_abnormal_hematopoietic_system0.91923278
83MP0005397_hematopoietic_system_phenotyp0.91923278
84MP0005503_abnormal_tendon_morphology0.90328545
85MP0002095_abnormal_skin_pigmentation0.89411006
86MP0002938_white_spotting0.89346942
87MP0002925_abnormal_cardiovascular_devel0.88077777
88MP0002722_abnormal_immune_system0.86647084
89MP0009697_abnormal_copulation0.85621640
90MP0005389_reproductive_system_phenotype0.85621191
91MP0002009_preneoplasia0.85110714
92MP0005266_abnormal_metabolism0.85052626
93MP0003941_abnormal_skin_development0.84082390
94MP0000490_abnormal_crypts_of0.83025861
95MP0002161_abnormal_fertility/fecundity0.81945484
96MP0005023_abnormal_wound_healing0.81189855
97MP0002006_tumorigenesis0.81105764
98MP0008438_abnormal_cutaneous_collagen0.79770158
99MP0001800_abnormal_humoral_immune0.78577574
100MP0003448_altered_tumor_morphology0.78388752
101MP0001286_abnormal_eye_development0.78363964
102MP0002160_abnormal_reproductive_system0.77786820
103MP0001191_abnormal_skin_condition0.77637834
104MP0003755_abnormal_palate_morphology0.77523685
105MP0005220_abnormal_exocrine_pancreas0.77415953
106MP0002166_altered_tumor_susceptibility0.77303663
107MP0009379_abnormal_foot_pigmentation0.75596737
108MP0002405_respiratory_system_inflammati0.74271935
109MP0001849_ear_inflammation0.73698980
110MP0002111_abnormal_tail_morphology0.73486050
111MP0000537_abnormal_urethra_morphology0.73288218
112MP0002282_abnormal_trachea_morphology0.73041385
113MP0010386_abnormal_urinary_bladder0.72612648
114MP0001119_abnormal_female_reproductive0.72540117
115MP0005621_abnormal_cell_physiology0.71935883
116MP0002398_abnormal_bone_marrow0.71864314
117MP0001851_eye_inflammation0.71847456
118MP0005253_abnormal_eye_physiology0.71631811
119MP0002932_abnormal_joint_morphology0.71367326
120MP0003091_abnormal_cell_migration0.71050792
121MP0005384_cellular_phenotype0.70075417
122MP0002114_abnormal_axial_skeleton0.69561620
123MP0003221_abnormal_cardiomyocyte_apopto0.69287346
124MP0000516_abnormal_urinary_system0.66938722
125MP0005367_renal/urinary_system_phenotyp0.66938722
126MP0000427_abnormal_hair_cycle0.66849758
127MP0002109_abnormal_limb_morphology0.65770137
128MP0003861_abnormal_nervous_system0.65640894
129MP0003385_abnormal_body_wall0.64996312
130MP0005391_vision/eye_phenotype0.64811673
131MP0002653_abnormal_ependyma_morphology0.64734578
132MP0008961_abnormal_basal_metabolism0.64370265
133MP0001177_atelectasis0.63483806
134MP0001764_abnormal_homeostasis0.62474200
135MP0001873_stomach_inflammation0.62119244
136MP0004782_abnormal_surfactant_physiolog0.59323734
137MP0004147_increased_porphyrin_level0.59016826
138MP0003868_abnormal_feces_composition0.58894981
139MP0002233_abnormal_nose_morphology0.58892998
140MP0000358_abnormal_cell_content/0.58017253

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.23594658
2Chromsome breakage (HP:0040012)3.65333765
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42216726
4Ectopic kidney (HP:0000086)3.19232858
5B lymphocytopenia (HP:0010976)3.09519999
6Severe combined immunodeficiency (HP:0004430)3.04252740
7Birth length less than 3rd percentile (HP:0003561)3.03595022
8Thyroiditis (HP:0100646)3.00818664
9Abnormality of chromosome stability (HP:0003220)2.99330995
10Selective tooth agenesis (HP:0001592)2.96650959
11Short 4th metacarpal (HP:0010044)2.95670121
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.95670121
13Increased nuchal translucency (HP:0010880)2.90935757
14Abnormality of B cell number (HP:0010975)2.86071788
15Medulloblastoma (HP:0002885)2.85320467
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.85243771
17Abnormality of DNA repair (HP:0003254)2.81565356
18Metaphyseal dysplasia (HP:0100255)2.79682868
19Impulsivity (HP:0100710)2.75349997
20Abnormality of the fingertips (HP:0001211)2.65256978
21Meckel diverticulum (HP:0002245)2.59570674
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.58027623
23Abnormality of the ileum (HP:0001549)2.56268084
24Pancreatic cysts (HP:0001737)2.53548218
25Combined immunodeficiency (HP:0005387)2.52339296
26Ependymoma (HP:0002888)2.50223457
27Renal cortical cysts (HP:0000803)2.45428340
28Cystic hygroma (HP:0000476)2.45243585
29Nephroblastoma (Wilms tumor) (HP:0002667)2.43913244
30Tubulointerstitial nephritis (HP:0001970)2.43812364
31Syringomyelia (HP:0003396)2.43225286
32Spinal cord lesions (HP:0100561)2.43225286
33Proximal placement of thumb (HP:0009623)2.43034909
34Absent frontal sinuses (HP:0002688)2.42341102
35Deviation of the thumb (HP:0009603)2.41084719
36Long eyelashes (HP:0000527)2.38276474
37Heterotopia (HP:0002282)2.38153945
38Fair hair (HP:0002286)2.35766322
39Embryonal renal neoplasm (HP:0011794)2.34871235
40Supernumerary spleens (HP:0009799)2.31415542
41Abnormality of the anterior horn cell (HP:0006802)2.31088993
42Degeneration of anterior horn cells (HP:0002398)2.31088993
43Hypoplastic iliac wings (HP:0002866)2.30803185
44Prominent nose (HP:0000448)2.28480544
45Abnormality of the renal cortex (HP:0011035)2.24811880
46Astrocytoma (HP:0009592)2.23363573
47Abnormality of the astrocytes (HP:0100707)2.23363573
48Abnormality of the preputium (HP:0100587)2.21436217
49Myelodysplasia (HP:0002863)2.21330351
50Acute lymphatic leukemia (HP:0006721)2.20497500
51Facial hemangioma (HP:0000329)2.20310166
52Cutaneous melanoma (HP:0012056)2.19173273
53Glioma (HP:0009733)2.18725022
54Small intestinal stenosis (HP:0012848)2.17900036
55Duodenal stenosis (HP:0100867)2.17900036
56Deep philtrum (HP:0002002)2.14295690
57Abnormality of the carotid arteries (HP:0005344)2.14113769
58True hermaphroditism (HP:0010459)2.12284415
59Papillary thyroid carcinoma (HP:0002895)2.08833557
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.07790119
61Absent/shortened dynein arms (HP:0200106)2.07790119
62Chronic hepatic failure (HP:0100626)2.06878319
63Rhabdomyosarcoma (HP:0002859)2.06528082
64Autoimmune hemolytic anemia (HP:0001890)2.05948508
65High pitched voice (HP:0001620)2.05381921
66Small hand (HP:0200055)2.04908351
67Sloping forehead (HP:0000340)2.04339054
68Abnormality of the 4th metacarpal (HP:0010012)2.02417106
69Entropion (HP:0000621)2.01688686
70Abnormal number of incisors (HP:0011064)2.01344780
71Colon cancer (HP:0003003)1.99942980
72Abnormality of the labia minora (HP:0012880)1.99790471
73Acute myeloid leukemia (HP:0004808)1.99245912
74Agnosia (HP:0010524)1.98482382
75Skull defect (HP:0001362)1.98269776
76Atresia of the external auditory canal (HP:0000413)1.98024133
77Patellar aplasia (HP:0006443)1.97685576
78Truncal obesity (HP:0001956)1.97406883
79Abnormality of eosinophils (HP:0001879)1.97206964
80Capillary hemangiomas (HP:0005306)1.96580212
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.94168450
82Low anterior hairline (HP:0000294)1.91753019
83Supernumerary ribs (HP:0005815)1.89741662
84Eosinophilia (HP:0001880)1.89409868
85Arteriovenous malformation (HP:0100026)1.88142244
86Neoplasm of the oral cavity (HP:0100649)1.87713421
87Abnormality of midbrain morphology (HP:0002418)1.86054938
88Molar tooth sign on MRI (HP:0002419)1.86054938
89Abnormal biliary tract morphology (HP:0012440)1.85867781
90IgM deficiency (HP:0002850)1.85319771
91Dislocated radial head (HP:0003083)1.84877002
92Hypoplastic labia majora (HP:0000059)1.84672692
93Hyperventilation (HP:0002883)1.83610100
94Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.83189720
95Submucous cleft hard palate (HP:0000176)1.82290161
96Aplasia/Hypoplasia of the patella (HP:0006498)1.82005909
97Hypoplasia of the thymus (HP:0000778)1.81935593
98Pancreatic fibrosis (HP:0100732)1.81884109
99Abnormal foot bone ossification (HP:0010675)1.81188699
100Cafe-au-lait spot (HP:0000957)1.79892653
101Hip dysplasia (HP:0001385)1.79850221
102Abnormality of the duodenum (HP:0002246)1.79768287
103Absent radius (HP:0003974)1.79180568
104Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78762857
105Neoplasm of striated muscle (HP:0009728)1.78612825
106Poikiloderma (HP:0001029)1.78501583
107Abnormality of the nasal septum (HP:0000419)1.78163539
108Curly hair (HP:0002212)1.77908194
109Trigonocephaly (HP:0000243)1.77728840
110Breast hypoplasia (HP:0003187)1.76988215
111Supernumerary bones of the axial skeleton (HP:0009144)1.76849293
112Neoplasm of the adrenal cortex (HP:0100641)1.76202580
113Neoplasm of the small intestine (HP:0100833)1.76128254
114Abnormality of the prostate (HP:0008775)1.75445817
115Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75145676
116Abnormality of the radial head (HP:0003995)1.74924259
117Dyschromatopsia (HP:0007641)1.74398169
118Panhypogammaglobulinemia (HP:0003139)1.73735285
119Medial flaring of the eyebrow (HP:0010747)1.72829442
120Abdominal situs inversus (HP:0003363)1.72422135
121Abnormality of abdominal situs (HP:0011620)1.72422135
122Sparse lateral eyebrow (HP:0005338)1.71475119
123Short ribs (HP:0000773)1.70948432
124Abnormality of the renal medulla (HP:0100957)1.70882243
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69996746
126Tubulointerstitial abnormality (HP:0001969)1.69484012
127Abnormality of the phalanges of the 5th finger (HP:0004213)1.68847939
128Central scotoma (HP:0000603)1.68695934
129Nephronophthisis (HP:0000090)1.67959455
130Clubbing of toes (HP:0100760)1.66242495
131Abnormality of the labia majora (HP:0012881)1.66146747
132Abnormality of the proximal phalanges of the hand (HP:0009834)1.66067524
133Sandal gap (HP:0001852)1.65900058
134Abnormal lung lobation (HP:0002101)1.65809156
135Aplasia involving forearm bones (HP:0009822)1.65027966
136Absent forearm bone (HP:0003953)1.65027966
137Pelvic girdle muscle weakness (HP:0003749)1.64866667
138Abnormality of the ischium (HP:0003174)1.64846763
139Squamous cell carcinoma (HP:0002860)1.64143349
140Long clavicles (HP:0000890)1.63957260
14111 pairs of ribs (HP:0000878)1.63339300
142Missing ribs (HP:0000921)1.63080584
143Macroorchidism (HP:0000053)1.62450863
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.62376965
145Renovascular hypertension (HP:0100817)1.62231366
146Renal duplication (HP:0000075)1.62114020
147Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.62027876
148Spondylolisthesis (HP:0003302)1.60195701
149Poor coordination (HP:0002370)1.60143748
150Protruding tongue (HP:0010808)1.59616309
151Limited elbow extension (HP:0001377)1.59123035
152Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.59111132
153Basal cell carcinoma (HP:0002671)1.58867067
154Oligodactyly (hands) (HP:0001180)1.58531708
155Overlapping toe (HP:0001845)1.58446128
156Abnormal spermatogenesis (HP:0008669)1.57918046
157Narrow palate (HP:0000189)1.57912439
158Abnormality of the epiphyses of the hand (HP:0005924)1.57540413
159Rhinitis (HP:0012384)1.56821988
160Biliary tract neoplasm (HP:0100574)1.56647310
161Congenital primary aphakia (HP:0007707)1.56553407
162Neoplasm of the tracheobronchial system (HP:0100552)1.56495841
163Malignant gastrointestinal tract tumors (HP:0006749)1.55780545
164Gastrointestinal carcinoma (HP:0002672)1.55780545
165Short middle phalanx of the 5th finger (HP:0004220)1.55754396
166Hypoplastic ischia (HP:0003175)1.54936939
167Embryonal neoplasm (HP:0002898)1.54452240
168Abnormal hair whorl (HP:0010721)1.54308489
169Bifid tongue (HP:0010297)1.54150958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.82138124
2NEK23.52243211
3CDK123.51304461
4WEE13.50094313
5MKNK12.88678796
6SRPK12.60936877
7MKNK22.54717574
8BMPR1B2.47252863
9ACVR1B2.41184746
10TTK2.22272824
11BUB12.14680021
12AKT32.11508251
13PNCK2.09779580
14ATR2.09459506
15TAOK32.01476384
16PDK42.00354383
17PDK32.00354383
18BRSK21.99037392
19TRIM281.92085301
20MST41.87154164
21NLK1.85400814
22PLK41.84179735
23PLK31.80011468
24PLK11.76310225
25BRD41.72930505
26CDK61.70677180
27TNIK1.61829622
28NEK11.61137705
29LATS11.61009713
30STK31.57858779
31CHEK11.57328835
32PASK1.54149286
33AURKB1.51988866
34TAF11.50164143
35STK391.50132995
36CDK41.47889525
37CHEK21.46091672
38TEC1.40322873
39ATM1.39725466
40TSSK61.39137075
41STK41.38907543
42ZAK1.36858564
43RPS6KA41.35345080
44CAMKK21.30152966
45ERBB31.29957666
46CDK71.28919652
47EIF2AK11.20390105
48RPS6KB21.19663745
49STK101.18815636
50PIK3CG1.10420085
51TTN1.10251099
52BMPR21.10201127
53DYRK31.09382493
54MAP4K21.06306515
55PIK3CA1.06191459
56CAMK1D1.05758118
57MTOR1.05410663
58CDK21.04791214
59TGFBR11.04454155
60STK38L1.02008954
61MELK1.01736688
62FGFR10.98856227
63ALK0.98306024
64TLK10.97933836
65PDK20.96270222
66MAP3K80.94504983
67MAP3K40.94248103
68VRK10.90960001
69CDK10.88907174
70PKN20.85872818
71CAMK1G0.82885417
72EEF2K0.82854983
73MAP3K100.81830172
74PAK40.75179737
75FGFR20.75010105
76PIM10.74912504
77FRK0.74289391
78MAP3K120.73097277
79BRSK10.70404585
80CDK90.66925730
81WNK30.65615872
82NUAK10.65050777
83MARK30.64595958
84YES10.64565057
85EPHA20.63966587
86PRKDC0.62854899
87RPS6KA50.60292163
88SCYL20.60200105
89MAPK140.56010483
90PAK20.54978492
91PBK0.53416670
92CSNK1D0.52675136
93DYRK1B0.52177396
94CHUK0.51239679
95IRAK10.51158628
96CSNK2A20.50851554
97PDGFRB0.50560234
98JAK10.50256604
99TESK10.48980218
100STK240.48095621
101PDGFRA0.47695900
102EIF2AK20.47566624
103CCNB10.47374212
104SIK20.46701103
105ERBB40.46226394
106OXSR10.46214299
107FGFR30.45518107
108CASK0.45401776
109BTK0.45232762
110CDK30.44427361
111CSNK1A1L0.44242819
112MAP3K140.43419052
113CSNK1E0.43206183
114GSK3B0.42268711
115PTK60.41306222
116NEK90.40792678
117KIT0.40319216
118MAPK10.39581687
119NEK60.39175767
120WNK10.38601809
121CDK80.38430930
122AURKA0.38166889
123AKT10.37741783
124CSNK2A10.37297457
125CLK10.36651526
126BCR0.36154832
127EIF2AK30.35732757
128MAPK80.35676565
129CSF1R0.35585130
130SGK20.35504349
131RAF10.34152860
132TXK0.33924008
133OBSCN0.33899669
134MAPK100.32616285
135DMPK0.30583694
136FLT30.30224637
137TRPM70.29892471
138PLK20.28857661

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.90034590
2DNA replication_Homo sapiens_hsa030303.83615706
3Mismatch repair_Homo sapiens_hsa034303.63466301
4RNA transport_Homo sapiens_hsa030133.25472099
5Cell cycle_Homo sapiens_hsa041103.16556625
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03107328
7Spliceosome_Homo sapiens_hsa030402.92843517
8Fanconi anemia pathway_Homo sapiens_hsa034602.83917216
9Homologous recombination_Homo sapiens_hsa034402.55302330
10mRNA surveillance pathway_Homo sapiens_hsa030152.53203612
11Nucleotide excision repair_Homo sapiens_hsa034202.46806732
12Protein export_Homo sapiens_hsa030602.39870872
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31092745
14Base excision repair_Homo sapiens_hsa034102.19140004
15One carbon pool by folate_Homo sapiens_hsa006702.17017641
16Non-homologous end-joining_Homo sapiens_hsa034502.09973484
17Basal transcription factors_Homo sapiens_hsa030222.02428751
18RNA degradation_Homo sapiens_hsa030181.95022980
19Systemic lupus erythematosus_Homo sapiens_hsa053221.92890808
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.88210582
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80791776
22p53 signaling pathway_Homo sapiens_hsa041151.74321128
23Viral carcinogenesis_Homo sapiens_hsa052031.58006074
24MicroRNAs in cancer_Homo sapiens_hsa052061.49820414
25Propanoate metabolism_Homo sapiens_hsa006401.43170992
26Antigen processing and presentation_Homo sapiens_hsa046121.41966387
27Oocyte meiosis_Homo sapiens_hsa041141.36702095
28Circadian rhythm_Homo sapiens_hsa047101.36646396
29Herpes simplex infection_Homo sapiens_hsa051681.30352868
30Epstein-Barr virus infection_Homo sapiens_hsa051691.30089191
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28259500
32RNA polymerase_Homo sapiens_hsa030201.26710229
33Small cell lung cancer_Homo sapiens_hsa052221.25263628
34HTLV-I infection_Homo sapiens_hsa051661.19719423
35Pyrimidine metabolism_Homo sapiens_hsa002401.17870382
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10548643
37Regulation of autophagy_Homo sapiens_hsa041401.04818014
38Lysine degradation_Homo sapiens_hsa003101.02586582
39Adherens junction_Homo sapiens_hsa045201.00672266
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99743534
41TGF-beta signaling pathway_Homo sapiens_hsa043500.99062909
42Asthma_Homo sapiens_hsa053100.96365984
43Proteasome_Homo sapiens_hsa030500.94126634
44Chronic myeloid leukemia_Homo sapiens_hsa052200.93940783
45Selenocompound metabolism_Homo sapiens_hsa004500.92041994
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89772611
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88377118
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.86877817
49Alcoholism_Homo sapiens_hsa050340.85683542
50Prostate cancer_Homo sapiens_hsa052150.84900046
51Measles_Homo sapiens_hsa051620.84243281
52Viral myocarditis_Homo sapiens_hsa054160.82844298
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81912304
54Hepatitis B_Homo sapiens_hsa051610.78262426
55Butanoate metabolism_Homo sapiens_hsa006500.78243452
56Colorectal cancer_Homo sapiens_hsa052100.78168630
57Hippo signaling pathway_Homo sapiens_hsa043900.77180473
58mTOR signaling pathway_Homo sapiens_hsa041500.77050054
59Basal cell carcinoma_Homo sapiens_hsa052170.76839790
60Proteoglycans in cancer_Homo sapiens_hsa052050.76263351
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.75429131
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74379050
63Nitrogen metabolism_Homo sapiens_hsa009100.72871963
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72758035
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70863326
66Purine metabolism_Homo sapiens_hsa002300.68369164
67B cell receptor signaling pathway_Homo sapiens_hsa046620.67910453
68FoxO signaling pathway_Homo sapiens_hsa040680.66480192
69T cell receptor signaling pathway_Homo sapiens_hsa046600.66287767
70Wnt signaling pathway_Homo sapiens_hsa043100.61115558
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60908976
72Focal adhesion_Homo sapiens_hsa045100.60588782
73Legionellosis_Homo sapiens_hsa051340.60438926
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.60258693
75Pathways in cancer_Homo sapiens_hsa052000.59917588
76Apoptosis_Homo sapiens_hsa042100.59734529
77Primary immunodeficiency_Homo sapiens_hsa053400.59552743
78Vitamin B6 metabolism_Homo sapiens_hsa007500.58950570
79Influenza A_Homo sapiens_hsa051640.58668591
80ECM-receptor interaction_Homo sapiens_hsa045120.56937715
81Toxoplasmosis_Homo sapiens_hsa051450.55485062
82Pancreatic cancer_Homo sapiens_hsa052120.54849970
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54723287
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54266773
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.53967819
86Notch signaling pathway_Homo sapiens_hsa043300.53476735
87Hedgehog signaling pathway_Homo sapiens_hsa043400.52965103
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52350277
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52126961
90Shigellosis_Homo sapiens_hsa051310.51965491
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.51727822
92Thyroid cancer_Homo sapiens_hsa052160.49794995
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.49465437
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49245773
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48492416
96HIF-1 signaling pathway_Homo sapiens_hsa040660.48467698
97Allograft rejection_Homo sapiens_hsa053300.47781814
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47583624
99Melanoma_Homo sapiens_hsa052180.47384974
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47200028
101Endometrial cancer_Homo sapiens_hsa052130.47177148
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46604653
103Dorso-ventral axis formation_Homo sapiens_hsa043200.46389313
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.46112586
105Platelet activation_Homo sapiens_hsa046110.45680967
106Non-small cell lung cancer_Homo sapiens_hsa052230.44914842
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44528622
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.44334418
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44243931
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44139276
111Ether lipid metabolism_Homo sapiens_hsa005650.43083253
112Acute myeloid leukemia_Homo sapiens_hsa052210.42673222
113Tight junction_Homo sapiens_hsa045300.41877125
114TNF signaling pathway_Homo sapiens_hsa046680.41748716
115N-Glycan biosynthesis_Homo sapiens_hsa005100.40865820
116Autoimmune thyroid disease_Homo sapiens_hsa053200.40406300
117Osteoclast differentiation_Homo sapiens_hsa043800.39968345
118Bladder cancer_Homo sapiens_hsa052190.36870647
119Graft-versus-host disease_Homo sapiens_hsa053320.36255580
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35980820
121Phototransduction_Homo sapiens_hsa047440.35403602
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34454282
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34453973
124Inositol phosphate metabolism_Homo sapiens_hsa005620.34172787
125Hematopoietic cell lineage_Homo sapiens_hsa046400.33971710
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33497155
127Glucagon signaling pathway_Homo sapiens_hsa049220.33042411
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31773575
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30695608
130Linoleic acid metabolism_Homo sapiens_hsa005910.30345624
131Olfactory transduction_Homo sapiens_hsa047400.29692520
132Type I diabetes mellitus_Homo sapiens_hsa049400.28756438
133Peroxisome_Homo sapiens_hsa041460.27041801
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25305513
135Chemical carcinogenesis_Homo sapiens_hsa052040.25286477

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