SMC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.41300141
2mitotic sister chromatid cohesion (GO:0007064)5.31878881
3mitotic chromosome condensation (GO:0007076)5.14927717
4nuclear pore organization (GO:0006999)4.96019904
5kinetochore organization (GO:0051383)4.77644842
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.67673377
7regulation of mitotic spindle checkpoint (GO:1903504)4.67673377
8mitotic metaphase plate congression (GO:0007080)4.63512345
9meiotic chromosome segregation (GO:0045132)4.56314835
10protein localization to kinetochore (GO:0034501)4.50189324
11metaphase plate congression (GO:0051310)4.29186490
12protein localization to chromosome, centromeric region (GO:0071459)4.22756266
13pore complex assembly (GO:0046931)4.18350358
14regulation of centrosome duplication (GO:0010824)4.15862944
15positive regulation of cell cycle checkpoint (GO:1901978)4.12152538
16DNA replication checkpoint (GO:0000076)4.10426081
17monoubiquitinated protein deubiquitination (GO:0035520)4.07253668
18attachment of spindle microtubules to kinetochore (GO:0008608)4.05886495
19sister chromatid segregation (GO:0000819)4.04589993
20regulation of RNA export from nucleus (GO:0046831)4.01323076
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.01300543
22mitotic sister chromatid segregation (GO:0000070)3.98196775
23chromatin remodeling at centromere (GO:0031055)3.95007424
24establishment of chromosome localization (GO:0051303)3.93766679
25replication fork processing (GO:0031297)3.93433621
26CENP-A containing nucleosome assembly (GO:0034080)3.92001187
27DNA unwinding involved in DNA replication (GO:0006268)3.90403720
28regulation of spindle organization (GO:0090224)3.88769807
29DNA replication-independent nucleosome organization (GO:0034724)3.83446230
30DNA replication-independent nucleosome assembly (GO:0006336)3.83446230
31mitotic nuclear envelope disassembly (GO:0007077)3.78613376
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.76409301
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.76409301
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.76409301
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.76161712
36histone exchange (GO:0043486)3.70924163
37kinetochore assembly (GO:0051382)3.70850043
38sister chromatid cohesion (GO:0007062)3.65512955
39DNA double-strand break processing (GO:0000729)3.63510354
40DNA replication-dependent nucleosome assembly (GO:0006335)3.59884277
41DNA replication-dependent nucleosome organization (GO:0034723)3.59884277
42regulation of sister chromatid cohesion (GO:0007063)3.57616543
43DNA replication initiation (GO:0006270)3.57373506
44pre-miRNA processing (GO:0031054)3.57114622
45positive regulation of chromosome segregation (GO:0051984)3.54173645
46double-strand break repair via nonhomologous end joining (GO:0006303)3.54091478
47non-recombinational repair (GO:0000726)3.54091478
48nuclear envelope disassembly (GO:0051081)3.52272728
49membrane disassembly (GO:0030397)3.52272728
50DNA strand elongation involved in DNA replication (GO:0006271)3.49535147
51regulation of centriole replication (GO:0046599)3.49087379
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47533416
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.47298649
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.47298649
55spindle checkpoint (GO:0031577)3.47223646
56protein localization to chromosome (GO:0034502)3.46736349
57regulation of mitotic spindle organization (GO:0060236)3.44958975
58regulation of chromosome segregation (GO:0051983)3.44464977
59regulation of spindle checkpoint (GO:0090231)3.41329830
60chromosome segregation (GO:0007059)3.40364182
61postreplication repair (GO:0006301)3.40215340
62chromosome condensation (GO:0030261)3.39801955
63* mitotic recombination (GO:0006312)3.39392756
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.38047900
65negative regulation of DNA recombination (GO:0045910)3.37642491
66chromatin assembly or disassembly (GO:0006333)3.35182762
67DNA strand elongation (GO:0022616)3.34770917
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.33615332
69establishment of integrated proviral latency (GO:0075713)3.28143123
70telomere maintenance via semi-conservative replication (GO:0032201)3.27908904
71DNA packaging (GO:0006323)3.24878365
72* telomere maintenance via recombination (GO:0000722)3.24410825
73ribosome assembly (GO:0042255)3.23640645
74regulation of DNA endoreduplication (GO:0032875)3.20855558
75negative regulation of DNA-dependent DNA replication (GO:2000104)3.20445453
76spindle assembly checkpoint (GO:0071173)3.20120937
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.19477462
78viral mRNA export from host cell nucleus (GO:0046784)3.19380511
79protein K6-linked ubiquitination (GO:0085020)3.18717205
80regulation of centrosome cycle (GO:0046605)3.18253449
81regulation of mitotic sister chromatid separation (GO:0010965)3.16399577
82regulation of mitotic sister chromatid segregation (GO:0033047)3.16399577
83regulation of sister chromatid segregation (GO:0033045)3.16399577
84somatic recombination of immunoglobulin gene segments (GO:0016447)3.16388633
85mitotic spindle checkpoint (GO:0071174)3.15158235
86synapsis (GO:0007129)3.13582928
87* double-strand break repair via homologous recombination (GO:0000724)3.13351849
88regulation of helicase activity (GO:0051095)3.12729899
89DNA topological change (GO:0006265)3.12536820
90negative regulation of mitotic sister chromatid separation (GO:2000816)3.12310721
91negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12310721
92negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12310721
93negative regulation of sister chromatid segregation (GO:0033046)3.12310721
94negative regulation of chromosome segregation (GO:0051985)3.11932376
95ATP-dependent chromatin remodeling (GO:0043044)3.10797002
96regulation of nucleobase-containing compound transport (GO:0032239)3.10631842
97* recombinational repair (GO:0000725)3.10219548
98mitotic spindle assembly checkpoint (GO:0007094)3.09345442
99purine nucleobase biosynthetic process (GO:0009113)3.08866647
100DNA strand renaturation (GO:0000733)3.08846809
101regulation of double-strand break repair (GO:2000779)3.08305077
102DNA duplex unwinding (GO:0032508)3.08026991
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07331432
104DNA geometric change (GO:0032392)3.07237607
105piRNA metabolic process (GO:0034587)3.05657760
106translesion synthesis (GO:0019985)3.04756177
107intra-S DNA damage checkpoint (GO:0031573)3.04558832
108heterochromatin organization (GO:0070828)3.04510434
109DNA synthesis involved in DNA repair (GO:0000731)3.04326875
110nucleobase biosynthetic process (GO:0046112)3.03354330
111IMP biosynthetic process (GO:0006188)3.02789537
112nucleotide-excision repair, DNA gap filling (GO:0006297)3.01483054
113regulation of histone H3-K9 methylation (GO:0051570)3.01013569
114maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00846871
115DNA conformation change (GO:0071103)2.98581360
116histone H2A monoubiquitination (GO:0035518)2.95320734
117mitotic G2/M transition checkpoint (GO:0044818)2.95123999
118telomere maintenance via telomere lengthening (GO:0010833)2.91616086
119resolution of meiotic recombination intermediates (GO:0000712)2.91212293
120dosage compensation (GO:0007549)2.87095834
121microtubule depolymerization (GO:0007019)2.86716388
122DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.83552909
123mismatch repair (GO:0006298)2.82900782
124gene silencing by RNA (GO:0031047)2.82270224
125* chromosome organization (GO:0051276)2.80836052
126centriole replication (GO:0007099)2.79631331
127negative regulation of histone methylation (GO:0031061)2.79475339
128chromatin assembly (GO:0031497)2.77367958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.09316439
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.91347259
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.92493851
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.29145648
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.86831593
6AR_21909140_ChIP-Seq_LNCAP_Human2.85725573
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82261848
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.79699313
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.77870409
10* E2F1_21310950_ChIP-Seq_MCF-7_Human2.65289066
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.32697743
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06156289
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02907478
14E2F7_22180533_ChIP-Seq_HELA_Human11.4440447
15MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96349558
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95685612
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94861875
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.92903520
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91388304
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91189277
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90954103
22VDR_23849224_ChIP-Seq_CD4+_Human1.87391729
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86761441
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.85582509
25* ELK1_19687146_ChIP-ChIP_HELA_Human1.85255621
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78392866
27* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76825306
28GATA1_22025678_ChIP-Seq_K562_Human1.76687114
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75574274
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69805538
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69679667
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61467974
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60298389
34XRN2_22483619_ChIP-Seq_HELA_Human1.57772102
35FOXP3_21729870_ChIP-Seq_TREG_Human1.54762413
36VDR_22108803_ChIP-Seq_LS180_Human1.53516519
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48958180
38DCP1A_22483619_ChIP-Seq_HELA_Human1.48644702
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48116010
40MYC_22102868_ChIP-Seq_BL_Human1.48007464
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46942112
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46540831
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45808239
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45014636
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.44849059
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44552666
47TAF15_26573619_Chip-Seq_HEK293_Human1.42681587
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39707655
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38787624
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38228135
51TTF2_22483619_ChIP-Seq_HELA_Human1.37354842
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37308122
53KDM5A_27292631_Chip-Seq_BREAST_Human1.37173276
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33883951
55CIITA_25753668_ChIP-Seq_RAJI_Human1.30097353
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27517035
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22287937
58GABP_19822575_ChIP-Seq_HepG2_Human1.21242238
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20005535
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17365224
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17043668
62P300_19829295_ChIP-Seq_ESCs_Human1.15336212
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14689682
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13743780
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11222175
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.10726824
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08822161
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08700340
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06995893
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06415378
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05529675
72MYC_18940864_ChIP-ChIP_HL60_Human1.05222948
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03452518
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03102178
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02724706
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.01403271
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00562643
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.00469649
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.00274833
80IGF1R_20145208_ChIP-Seq_DFB_Human0.99065884
81ZNF274_21170338_ChIP-Seq_K562_Hela0.98785463
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98704997
83MYB_26560356_Chip-Seq_TH1_Human0.98321888
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98093680
85KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96883524
86MYB_26560356_Chip-Seq_TH2_Human0.96778841
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96625413
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96522799
89* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95599551
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95254346
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94090184
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93255250
93TFEB_21752829_ChIP-Seq_HELA_Human0.93025935
94SPI1_23547873_ChIP-Seq_NB4_Human0.91675098
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91518315
96* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90790128
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90145030
98EWS_26573619_Chip-Seq_HEK293_Human0.89953347
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88827994
100* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87881275
101* ETV1_20927104_ChIP-Seq_GIST48_Human0.87828225
102PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87802889
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87653228
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86585226
105CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85995669
106THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85660673
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.84722655
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84056390
109STAT3_23295773_ChIP-Seq_U87_Human0.83888061
110ER_23166858_ChIP-Seq_MCF-7_Human0.83140544
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.82244326
112SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81959826
113CBP_20019798_ChIP-Seq_JUKART_Human0.81889051
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81889051
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81308195
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.81147925
117PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79232685
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.79231464
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79151461
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79151461
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79151461
122FUS_26573619_Chip-Seq_HEK293_Human0.78882559
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.75930533
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75440185
125CHD1_26751641_Chip-Seq_LNCaP_Human0.74532288
126BRD4_25478319_ChIP-Seq_HGPS_Human0.73344967
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.72834285
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72750901
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72499421
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72385971
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.71122730
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70561061
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.69746358
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69637880
135UTX_26944678_Chip-Seq_JUKART_Human0.68205548
136* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.66358629
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65766512
138IRF8_21731497_ChIP-ChIP_J774_Mouse0.64843661
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.63754752
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.58513298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.10781988
2MP0010094_abnormal_chromosome_stability4.09510699
3MP0008057_abnormal_DNA_replication3.90574480
4MP0008877_abnormal_DNA_methylation3.73622000
5MP0003111_abnormal_nucleus_morphology3.46754033
6MP0003077_abnormal_cell_cycle3.46751364
7MP0004957_abnormal_blastocyst_morpholog3.15297928
8MP0008007_abnormal_cellular_replicative2.73978054
9MP0008058_abnormal_DNA_repair2.69433714
10MP0009697_abnormal_copulation2.59863404
11MP0003123_paternal_imprinting2.26478201
12MP0002396_abnormal_hematopoietic_system2.16074183
13MP0010352_gastrointestinal_tract_polyps2.06473089
14MP0010307_abnormal_tumor_latency2.02439599
15MP0008932_abnormal_embryonic_tissue2.01939881
16MP0003121_genomic_imprinting2.00916136
17MP0005076_abnormal_cell_differentiation1.98689182
18MP0001730_embryonic_growth_arrest1.97401216
19MP0000350_abnormal_cell_proliferation1.94871785
20MP0004808_abnormal_hematopoietic_stem1.76857670
21MP0003787_abnormal_imprinting1.72276021
22MP0001697_abnormal_embryo_size1.58662865
23MP0005380_embryogenesis_phenotype1.55266748
24MP0001672_abnormal_embryogenesis/_devel1.55266748
25MP0002697_abnormal_eye_size1.51586289
26MP0002210_abnormal_sex_determination1.51211235
27MP0002009_preneoplasia1.49266166
28MP0002084_abnormal_developmental_patter1.44707874
29MP0001929_abnormal_gametogenesis1.40972558
30MP0003786_premature_aging1.40054786
31MP0003984_embryonic_growth_retardation1.39527704
32MP0002877_abnormal_melanocyte_morpholog1.39521796
33MP0003763_abnormal_thymus_physiology1.37820591
34MP0002088_abnormal_embryonic_growth/wei1.36992753
35MP0002085_abnormal_embryonic_tissue1.36510206
36MP0003943_abnormal_hepatobiliary_system1.35713782
37MP0004197_abnormal_fetal_growth/weight/1.30389135
38MP0003937_abnormal_limbs/digits/tail_de1.28869909
39MP0002086_abnormal_extraembryonic_tissu1.25513747
40MP0000490_abnormal_crypts_of1.25450733
41MP0002080_prenatal_lethality1.21802182
42MP0001145_abnormal_male_reproductive1.21786773
43MP0003890_abnormal_embryonic-extraembry1.21370860
44MP0002019_abnormal_tumor_incidence1.17762753
45MP0000653_abnormal_sex_gland1.17318689
46MP0001661_extended_life_span1.13545012
47MP0000569_abnormal_digit_pigmentation1.11629231
48MP0004185_abnormal_adipocyte_glucose1.11537921
49MP0000703_abnormal_thymus_morphology1.11332641
50MP0000372_irregular_coat_pigmentation1.11213672
51MP0002234_abnormal_pharynx_morphology1.10772247
52MP0006054_spinal_hemorrhage1.10558095
53MP0002006_tumorigenesis1.10305158
54MP0000313_abnormal_cell_death1.07536406
55MP0001119_abnormal_female_reproductive1.06297681
56MP0003567_abnormal_fetal_cardiomyocyte1.04741882
57MP0005187_abnormal_penis_morphology1.04522383
58MP0003119_abnormal_digestive_system1.04489187
59MP0002398_abnormal_bone_marrow1.02173854
60MP0003221_abnormal_cardiomyocyte_apopto0.98778422
61MP0006072_abnormal_retinal_apoptosis0.97254153
62MP0002233_abnormal_nose_morphology0.96412557
63MP0009672_abnormal_birth_weight0.96356631
64MP0000428_abnormal_craniofacial_morphol0.95183220
65MP0002166_altered_tumor_susceptibility0.94426859
66MP0009703_decreased_birth_body0.94396398
67MP0010030_abnormal_orbit_morphology0.92601525
68MP0009333_abnormal_splenocyte_physiolog0.92207653
69MP0006292_abnormal_olfactory_placode0.91931815
70MP0000647_abnormal_sebaceous_gland0.91913003
71MP0000733_abnormal_muscle_development0.91464962
72MP0003718_maternal_effect0.90513097
73MP0005391_vision/eye_phenotype0.90178432
74MP0002092_abnormal_eye_morphology0.90084345
75MP0002163_abnormal_gland_morphology0.89684377
76MP0003950_abnormal_plasma_membrane0.87713095
77MP0009053_abnormal_anal_canal0.87346276
78MP0002102_abnormal_ear_morphology0.85394003
79MP0001545_abnormal_hematopoietic_system0.85291278
80MP0005397_hematopoietic_system_phenotyp0.85291278
81MP0005551_abnormal_eye_electrophysiolog0.83957179
82MP0003646_muscle_fatigue0.83421957
83MP0001915_intracranial_hemorrhage0.83080552
84MP0005253_abnormal_eye_physiology0.82774563
85MP0002722_abnormal_immune_system0.82399451
86MP0000432_abnormal_head_morphology0.82256645
87MP0003935_abnormal_craniofacial_develop0.82124857
88MP0005408_hypopigmentation0.81967559
89MP0001324_abnormal_eye_pigmentation0.81832292
90MP0008995_early_reproductive_senescence0.81780991
91MP0003315_abnormal_perineum_morphology0.80879355
92MP0003705_abnormal_hypodermis_morpholog0.79542486
93MP0008438_abnormal_cutaneous_collagen0.79490290
94MP0002822_catalepsy0.78192032
95MP0002111_abnormal_tail_morphology0.77968068
96MP0003941_abnormal_skin_development0.77159932
97MP0000689_abnormal_spleen_morphology0.76936543
98MP0003698_abnormal_male_reproductive0.76846898
99MP0003755_abnormal_palate_morphology0.76600061
100MP0001293_anophthalmia0.76471655
101MP0005621_abnormal_cell_physiology0.76264972
102MP0001800_abnormal_humoral_immune0.74963244
103MP0006035_abnormal_mitochondrial_morpho0.74577003
104MP0005395_other_phenotype0.73849311
105MP0004147_increased_porphyrin_level0.73829007
106MP0003448_altered_tumor_morphology0.73577203
107MP0009250_abnormal_appendicular_skeleto0.71912889
108MP0002160_abnormal_reproductive_system0.70806363
109MP0005384_cellular_phenotype0.70749545
110MP0003136_yellow_coat_color0.70478247
111MP0003861_abnormal_nervous_system0.70299570
112MP0000383_abnormal_hair_follicle0.69234267
113MP0005389_reproductive_system_phenotype0.68869601
114MP0002925_abnormal_cardiovascular_devel0.67541190
115MP0000358_abnormal_cell_content/0.67385471
116MP0002405_respiratory_system_inflammati0.67174382
117MP0005075_abnormal_melanosome_morpholog0.66894451
118MP0003385_abnormal_body_wall0.66480760
119MP0001286_abnormal_eye_development0.65709300
120MP0000716_abnormal_immune_system0.65683131
121MP0004233_abnormal_muscle_weight0.65409319
122MP0005195_abnormal_posterior_eye0.65307774
123MP0000427_abnormal_hair_cycle0.64549924
124MP0002429_abnormal_blood_cell0.64512504
125MP0002751_abnormal_autonomic_nervous0.63043916
126MP0000858_altered_metastatic_potential0.63019173
127MP0003115_abnormal_respiratory_system0.62752716
128MP0000631_abnormal_neuroendocrine_gland0.62655303
129MP0005503_abnormal_tendon_morphology0.62617876
130MP0005023_abnormal_wound_healing0.62351473
131MP0002452_abnormal_antigen_presenting0.62275006
132MP0001299_abnormal_eye_distance/0.62270655
133MP0003828_pulmonary_edema0.62089440
134MP0002938_white_spotting0.61933007
135MP0003699_abnormal_female_reproductive0.61492472
136MP0005671_abnormal_response_to0.60982962
137MP0005197_abnormal_uvea_morphology0.60785588

Predicted human phenotypes

RankGene SetZ-score
1Posterior subcapsular cataract (HP:0007787)5.63881255
2Chromsome breakage (HP:0040012)4.75090325
3Central scotoma (HP:0000603)4.30818253
4Volvulus (HP:0002580)4.07287636
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.06074684
6Scotoma (HP:0000575)3.98186212
7Abnormality of chromosome stability (HP:0003220)3.63226036
8Intestinal atresia (HP:0011100)3.56368739
9Subcapsular cataract (HP:0000523)3.53419995
10Birth length less than 3rd percentile (HP:0003561)3.42302217
11Facial hemangioma (HP:0000329)3.14518449
12Ectopic kidney (HP:0000086)3.10331479
13Meckel diverticulum (HP:0002245)2.99860249
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.82579062
15Abnormality of the preputium (HP:0100587)2.81184213
16Abnormality of the ileum (HP:0001549)2.78955507
17Abnormality of the fingertips (HP:0001211)2.78649258
18Impulsivity (HP:0100710)2.69467352
19Acute myeloid leukemia (HP:0004808)2.66328606
20Patellar aplasia (HP:0006443)2.64251996
21Septo-optic dysplasia (HP:0100842)2.63117946
22Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.59713326
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59088096
24Short 4th metacarpal (HP:0010044)2.59088096
25Deviation of the thumb (HP:0009603)2.53131810
26Aplasia/Hypoplasia of the patella (HP:0006498)2.50873432
27Myelodysplasia (HP:0002863)2.47344726
28Proximal placement of thumb (HP:0009623)2.45850152
29Papillary thyroid carcinoma (HP:0002895)2.44931676
30Selective tooth agenesis (HP:0001592)2.41087637
31Ependymoma (HP:0002888)2.39242230
32Nephroblastoma (Wilms tumor) (HP:0002667)2.38212787
33Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.37529791
34Capillary hemangiomas (HP:0005306)2.33212115
35Duodenal stenosis (HP:0100867)2.32531851
36Small intestinal stenosis (HP:0012848)2.32531851
37Increased nuchal translucency (HP:0010880)2.32425012
38Prostate neoplasm (HP:0100787)2.32178500
39Medulloblastoma (HP:0002885)2.31242606
40Esophageal atresia (HP:0002032)2.30478046
41Colon cancer (HP:0003003)2.30233216
42Cortical dysplasia (HP:0002539)2.30159960
43Embryonal renal neoplasm (HP:0011794)2.29334008
44Glioma (HP:0009733)2.28693203
45Abnormality of the labia minora (HP:0012880)2.27913678
46Depressed nasal tip (HP:0000437)2.24828033
47Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.23231511
48Acanthocytosis (HP:0001927)2.22326873
49Deep philtrum (HP:0002002)2.21062555
50Astrocytoma (HP:0009592)2.16857608
51Abnormality of the astrocytes (HP:0100707)2.16857608
52Degeneration of anterior horn cells (HP:0002398)2.16406823
53Abnormality of the anterior horn cell (HP:0006802)2.16406823
54Long eyelashes (HP:0000527)2.15734562
55Sloping forehead (HP:0000340)2.14678339
56Abnormal spermatogenesis (HP:0008669)2.14016842
57Prominent nose (HP:0000448)2.08644517
58Breast hypoplasia (HP:0003187)2.08043615
59Abnormality of the carotid arteries (HP:0005344)2.07888577
60Gastrointestinal atresia (HP:0002589)2.07273772
61Abnormality of the phalanges of the 5th finger (HP:0004213)2.06822896
62Abnormality of DNA repair (HP:0003254)2.06329423
6311 pairs of ribs (HP:0000878)2.05823342
64Pancreatic islet-cell hyperplasia (HP:0004510)2.02781916
65High pitched voice (HP:0001620)2.02556260
66Short thumb (HP:0009778)2.00652298
67Sandal gap (HP:0001852)2.00363038
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.00051311
69Oligodactyly (HP:0012165)1.99745658
70Neoplasm of the colon (HP:0100273)1.99303971
71Clubbing of toes (HP:0100760)1.99099987
72Abnormality of the septum pellucidum (HP:0007375)1.98964625
73Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98613637
74Neoplasm of the small intestine (HP:0100833)1.97994511
75Hepatoblastoma (HP:0002884)1.97526245
76Embryonal neoplasm (HP:0002898)1.96987458
77Abnormal lung lobation (HP:0002101)1.95465328
78Truncal obesity (HP:0001956)1.94656707
79Atresia of the external auditory canal (HP:0000413)1.93970437
80Cafe-au-lait spot (HP:0000957)1.92401421
81Triphalangeal thumb (HP:0001199)1.92007502
82Neoplasm of the pancreas (HP:0002894)1.90778722
83Neoplasm of striated muscle (HP:0009728)1.89364774
84Microglossia (HP:0000171)1.88642865
85Ankle contracture (HP:0006466)1.87986348
86Blepharitis (HP:0000498)1.87855258
87Abnormality of methionine metabolism (HP:0010901)1.87189795
88Abnormality of the duodenum (HP:0002246)1.86096481
89Thyroid carcinoma (HP:0002890)1.85842464
90Duplicated collecting system (HP:0000081)1.83858355
91Biliary tract neoplasm (HP:0100574)1.81532268
92Wrist flexion contracture (HP:0001239)1.79993542
93Cystic hygroma (HP:0000476)1.79947726
94Absent frontal sinuses (HP:0002688)1.77963604
95Abnormal number of incisors (HP:0011064)1.77797406
96Oligodactyly (hands) (HP:0001180)1.77381516
97Azoospermia (HP:0000027)1.76702074
98Bony spicule pigmentary retinopathy (HP:0007737)1.76306804
99Absent radius (HP:0003974)1.75793824
100Arteriovenous malformation (HP:0100026)1.75756341
101Subacute progressive viral hepatitis (HP:0006572)1.75328223
102Malignant gastrointestinal tract tumors (HP:0006749)1.75315088
103Gastrointestinal carcinoma (HP:0002672)1.75315088
104Diastasis recti (HP:0001540)1.74992738
105Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74923106
106Supernumerary spleens (HP:0009799)1.74889101
107Cutaneous melanoma (HP:0012056)1.74398747
108Squamous cell carcinoma (HP:0002860)1.74171398
109Bone marrow hypocellularity (HP:0005528)1.73457731
110Dislocated radial head (HP:0003083)1.73203220
111Basal cell carcinoma (HP:0002671)1.73010484
112Premature graying of hair (HP:0002216)1.71748983
113Sparse lateral eyebrow (HP:0005338)1.71263858
114Slender long bone (HP:0003100)1.70648954
115Rhabdomyosarcoma (HP:0002859)1.70288453
116Tracheoesophageal fistula (HP:0002575)1.70273834
117Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69265074
118Horseshoe kidney (HP:0000085)1.69057925
119Small hand (HP:0200055)1.68903017
120Facial asymmetry (HP:0000324)1.68118372
121Short middle phalanx of the 5th finger (HP:0004220)1.67026405
122Abnormality of the phalanges of the hallux (HP:0010057)1.66574212
1232-3 toe syndactyly (HP:0004691)1.63849017
124Absent septum pellucidum (HP:0001331)1.63368942
125Tubulointerstitial nephritis (HP:0001970)1.62866456
126T lymphocytopenia (HP:0005403)1.62768138
127Aplasia involving forearm bones (HP:0009822)1.62269076
128Absent forearm bone (HP:0003953)1.62269076
129Agnosia (HP:0010524)1.61155301
130Abnormality of chromosome segregation (HP:0002916)1.60484681
131Constricted visual fields (HP:0001133)1.60290784
132Reticulocytopenia (HP:0001896)1.59910333
133Astigmatism (HP:0000483)1.59855600
134Microtia (HP:0008551)1.59801446
135Abnormality of the 4th metacarpal (HP:0010012)1.59536522
136Abnormality of the radial head (HP:0003995)1.59488809
137Ovarian neoplasm (HP:0100615)1.59444346
138Overlapping toe (HP:0001845)1.59038960
139Bifid tongue (HP:0010297)1.58733313
140Male infertility (HP:0003251)1.58597435
141Gonadotropin excess (HP:0000837)1.58290710
142Choanal atresia (HP:0000453)1.57719897
143Abnormality of the calcaneus (HP:0008364)1.57631551
144Neoplasm of the oral cavity (HP:0100649)1.57032086
145Skull defect (HP:0001362)1.56964068
146Lymphoma (HP:0002665)1.56838148
147Abnormal biliary tract morphology (HP:0012440)1.56626154
148Aplastic anemia (HP:0001915)1.56614698
149Uterine neoplasm (HP:0010784)1.56585965
150Partial agenesis of the corpus callosum (HP:0001338)1.56152106
151Neoplasm of the adrenal cortex (HP:0100641)1.55576716
152Abnormality of the renal collecting system (HP:0004742)1.55562180
153Spinal cord lesions (HP:0100561)1.55400591
154Syringomyelia (HP:0003396)1.55400591
155Heterotopia (HP:0002282)1.54876074
156Missing ribs (HP:0000921)1.54855939
157Chronic hepatic failure (HP:0100626)1.54671705
158Pulmonary fibrosis (HP:0002206)1.54443163
159Abnormality of homocysteine metabolism (HP:0010919)1.53911986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.56146380
2NEK23.12982129
3WEE13.12086184
4PLK42.88994981
5LATS12.86535995
6SRPK12.74017971
7CDK122.59695700
8TTK2.50956692
9STK32.31233989
10BRSK22.28617612
11EIF2AK12.03754594
12RPS6KA42.03238727
13ACVR1B1.96815509
14PLK11.92198540
15CHEK21.84804996
16BUB11.84622177
17AURKB1.78572265
18STK38L1.75327906
19MKNK11.73211733
20PLK31.72721374
21MST41.68910724
22ATR1.68709580
23PASK1.62645087
24NUAK11.59917268
25STK101.54710368
26BMPR1B1.51167568
27TAF11.50056478
28CHEK11.47494296
29MKNK21.44643220
30TNIK1.41524410
31CDK41.41431405
32DYRK31.38354000
33BCR1.34423216
34CDK71.32958234
35ATM1.31517562
36CCNB11.29640204
37MELK1.29349457
38WNK31.28359169
39LATS21.26292409
40NEK11.22696620
41STK41.22589965
42FRK1.15128639
43CDK61.11247841
44STK241.10335245
45VRK11.07117543
46CDK91.07055532
47MAP3K81.05616946
48TRIM281.02801806
49KSR11.02109623
50EIF2AK31.00297948
51TLK10.92833444
52CDK80.92545955
53BRSK10.92464517
54ZAK0.91954213
55CDK20.89164021
56PIM10.89139978
57TGFBR10.88370232
58PDK40.87151446
59PDK30.87151446
60FGFR10.86844821
61NME10.86767670
62PBK0.84854048
63RPS6KB20.84167280
64MAP3K100.83380098
65MAP4K10.81276520
66RPS6KA50.78077304
67EEF2K0.77379257
68MAP3K120.76174688
69CDK30.76033087
70CDK10.75615371
71JAK30.72526578
72BRD40.70885422
73CSNK1E0.69912314
74CSNK1G10.69074967
75MARK30.67090577
76DMPK0.67038867
77NEK90.66468870
78TXK0.64466518
79STK390.63319233
80TSSK60.62309609
81SCYL20.61438872
82TESK20.61141719
83MAP3K40.61031494
84CLK10.57627002
85CAMK1G0.55601312
86AURKA0.54674999
87OXSR10.53024412
88EIF2AK20.52870607
89PNCK0.52660563
90FGFR30.52198595
91TEC0.50956831
92RAF10.50055297
93TRPM70.49828267
94PRKD30.49561019
95CHUK0.49203556
96PRKDC0.46914993
97PDGFRB0.46366587
98ERBB30.45924877
99NME20.45766022
100WNK40.45287804
101TTN0.44343758
102LRRK20.44304243
103CSNK2A10.43947627
104MTOR0.43039330
105MAPK140.41908800
106EPHA30.41342520
107YES10.40122871
108WNK10.39777874
109BMPR20.39777474
110BRAF0.39533874
111CDK190.38998799
112TAOK30.38965543
113PDK20.38517173
114ALK0.38210708
115MET0.37957175
116ERBB40.37893149
117NLK0.37867279
118RPS6KB10.37404986
119PRKAA20.37161471
120CSNK2A20.36977255
121ITK0.34541512
122GSK3B0.34507386
123MST1R0.33492499
124AKT30.32747103
125CSNK1D0.30768415
126AKT10.28964475
127PAK20.28241723
128PLK20.27384640
129CSF1R0.25891531

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.84345076
2Mismatch repair_Homo sapiens_hsa034303.42399640
3Cell cycle_Homo sapiens_hsa041103.40996248
4Homologous recombination_Homo sapiens_hsa034403.04554779
5RNA transport_Homo sapiens_hsa030132.83456522
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81734453
7Spliceosome_Homo sapiens_hsa030402.65172572
8Fanconi anemia pathway_Homo sapiens_hsa034602.63705046
9Base excision repair_Homo sapiens_hsa034102.43892550
10Nucleotide excision repair_Homo sapiens_hsa034202.43103185
11Basal transcription factors_Homo sapiens_hsa030222.38498366
12Non-homologous end-joining_Homo sapiens_hsa034502.35423081
13RNA degradation_Homo sapiens_hsa030182.32127007
14RNA polymerase_Homo sapiens_hsa030202.20852853
15mRNA surveillance pathway_Homo sapiens_hsa030151.99400509
16p53 signaling pathway_Homo sapiens_hsa041151.98585718
17One carbon pool by folate_Homo sapiens_hsa006701.59797203
18Pyrimidine metabolism_Homo sapiens_hsa002401.58658349
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46740420
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.43750281
21Herpes simplex infection_Homo sapiens_hsa051681.40966449
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40364105
23Systemic lupus erythematosus_Homo sapiens_hsa053221.39465321
24Propanoate metabolism_Homo sapiens_hsa006401.38127296
25Oocyte meiosis_Homo sapiens_hsa041141.34656931
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34586121
27Viral carcinogenesis_Homo sapiens_hsa052031.33693708
28MicroRNAs in cancer_Homo sapiens_hsa052061.32015344
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30235432
30Antigen processing and presentation_Homo sapiens_hsa046121.28430887
31Epstein-Barr virus infection_Homo sapiens_hsa051691.27518408
32Steroid biosynthesis_Homo sapiens_hsa001001.23616345
33HTLV-I infection_Homo sapiens_hsa051661.18639644
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18027378
35Small cell lung cancer_Homo sapiens_hsa052221.15560863
36Proteasome_Homo sapiens_hsa030501.14245069
37TGF-beta signaling pathway_Homo sapiens_hsa043501.13850168
38Pyruvate metabolism_Homo sapiens_hsa006201.12028005
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.06051258
40Primary immunodeficiency_Homo sapiens_hsa053401.05356708
41Pancreatic cancer_Homo sapiens_hsa052121.01160227
42Adherens junction_Homo sapiens_hsa045200.97341616
43Colorectal cancer_Homo sapiens_hsa052100.95743634
44Ribosome_Homo sapiens_hsa030100.95213727
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94558232
46Hepatitis B_Homo sapiens_hsa051610.92510820
47Measles_Homo sapiens_hsa051620.91373106
48Purine metabolism_Homo sapiens_hsa002300.90437648
49Prostate cancer_Homo sapiens_hsa052150.87556422
50Chronic myeloid leukemia_Homo sapiens_hsa052200.87487672
51Viral myocarditis_Homo sapiens_hsa054160.83600660
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75689706
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73993021
54Thyroid cancer_Homo sapiens_hsa052160.73495102
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71750970
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70066622
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69018570
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.68439516
59T cell receptor signaling pathway_Homo sapiens_hsa046600.68329859
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67979585
61B cell receptor signaling pathway_Homo sapiens_hsa046620.67790033
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66566633
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65534050
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64802814
65Apoptosis_Homo sapiens_hsa042100.64514656
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64349036
67Shigellosis_Homo sapiens_hsa051310.63240090
68Hematopoietic cell lineage_Homo sapiens_hsa046400.62900357
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62314588
70Leishmaniasis_Homo sapiens_hsa051400.62030900
71Influenza A_Homo sapiens_hsa051640.61462308
72Hippo signaling pathway_Homo sapiens_hsa043900.60946626
73Alcoholism_Homo sapiens_hsa050340.59497082
74FoxO signaling pathway_Homo sapiens_hsa040680.59095770
75Pathways in cancer_Homo sapiens_hsa052000.58480221
76Biosynthesis of amino acids_Homo sapiens_hsa012300.58258549
77mTOR signaling pathway_Homo sapiens_hsa041500.56559135
78Non-small cell lung cancer_Homo sapiens_hsa052230.55921785
79Legionellosis_Homo sapiens_hsa051340.54490117
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53896643
81Toxoplasmosis_Homo sapiens_hsa051450.53020319
82Dorso-ventral axis formation_Homo sapiens_hsa043200.51266447
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50223804
84Proteoglycans in cancer_Homo sapiens_hsa052050.49495257
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.48689680
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.48499660
87Renal cell carcinoma_Homo sapiens_hsa052110.48144158
88Protein export_Homo sapiens_hsa030600.46089635
89Endometrial cancer_Homo sapiens_hsa052130.46083164
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45677525
91Focal adhesion_Homo sapiens_hsa045100.45551742
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45460468
93Melanoma_Homo sapiens_hsa052180.45159447
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44092785
95Osteoclast differentiation_Homo sapiens_hsa043800.43744442
96Wnt signaling pathway_Homo sapiens_hsa043100.43519685
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42697301
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42598253
99Basal cell carcinoma_Homo sapiens_hsa052170.41190940
100Lysine degradation_Homo sapiens_hsa003100.40263891
101Notch signaling pathway_Homo sapiens_hsa043300.40241766
102Circadian rhythm_Homo sapiens_hsa047100.40162637
103Olfactory transduction_Homo sapiens_hsa047400.40134916
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39880050
105Autoimmune thyroid disease_Homo sapiens_hsa053200.39767195
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38948062
107Acute myeloid leukemia_Homo sapiens_hsa052210.38054097
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38051734
109Platelet activation_Homo sapiens_hsa046110.37298737
110TNF signaling pathway_Homo sapiens_hsa046680.37179805
111Prolactin signaling pathway_Homo sapiens_hsa049170.36854195
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36671781
113Nitrogen metabolism_Homo sapiens_hsa009100.34558051
114Taste transduction_Homo sapiens_hsa047420.34266451
115Vitamin B6 metabolism_Homo sapiens_hsa007500.33381071
116HIF-1 signaling pathway_Homo sapiens_hsa040660.33056352
117Phototransduction_Homo sapiens_hsa047440.32076949
118Butanoate metabolism_Homo sapiens_hsa006500.31467498
119Selenocompound metabolism_Homo sapiens_hsa004500.30889621
120Hedgehog signaling pathway_Homo sapiens_hsa043400.30485643
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30289537
122Folate biosynthesis_Homo sapiens_hsa007900.28641360
123N-Glycan biosynthesis_Homo sapiens_hsa005100.28578797
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28539397
125Carbon metabolism_Homo sapiens_hsa012000.27873465
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27823372
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23825057
128Metabolic pathways_Homo sapiens_hsa011000.21960631
129Tight junction_Homo sapiens_hsa045300.21776395
130Retinol metabolism_Homo sapiens_hsa008300.21062179
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20435297
132Fatty acid metabolism_Homo sapiens_hsa012120.19932196
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17338037
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.17302611
135Vitamin digestion and absorption_Homo sapiens_hsa049770.17037534
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14903427
137Fatty acid degradation_Homo sapiens_hsa000710.08604975
138Huntingtons disease_Homo sapiens_hsa050160.08250208
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.07893198
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.07879212
141Fatty acid biosynthesis_Homo sapiens_hsa000610.07573752

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