SMCHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains a hinge region domain found in members of the SMC (structural maintenance of chromosomes) protein family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.98944734
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.98944734
3regulation of B cell receptor signaling pathway (GO:0050855)5.73553182
4detection of molecule of bacterial origin (GO:0032490)5.64683912
5modulation by symbiont of host defense response (GO:0052031)5.61328505
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.61328505
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.61328505
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.61328505
9modulation by symbiont of host immune response (GO:0052553)5.61328505
10positive regulation by symbiont of host defense response (GO:0052509)5.61328505
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.59257384
12nuclear pore complex assembly (GO:0051292)5.26027338
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.08211293
14microglial cell activation (GO:0001774)4.95062079
15mitotic sister chromatid cohesion (GO:0007064)4.83685057
16regulation of gamma-delta T cell activation (GO:0046643)4.79248995
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.79025086
18nuclear pore organization (GO:0006999)4.78678985
19regulation of gamma-delta T cell differentiation (GO:0045586)4.76427210
20macrophage activation involved in immune response (GO:0002281)4.61835936
21cellular extravasation (GO:0045123)4.38907391
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.38508177
23detection of external biotic stimulus (GO:0098581)4.33818431
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33386785
25negative T cell selection (GO:0043383)4.32709624
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.32185083
27negative thymic T cell selection (GO:0045060)4.26807182
28regulation of interferon-beta biosynthetic process (GO:0045357)4.20026689
29DNA unwinding involved in DNA replication (GO:0006268)4.16382698
30B cell receptor signaling pathway (GO:0050853)4.16106436
31neutrophil mediated immunity (GO:0002446)4.13763519
32regulation of DNA endoreduplication (GO:0032875)4.11996435
33detection of other organism (GO:0098543)4.10474857
34antigen processing and presentation of endogenous antigen (GO:0019883)4.09438166
35macrophage activation (GO:0042116)4.08428035
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.02132144
37positive T cell selection (GO:0043368)4.01999257
38response to interleukin-15 (GO:0070672)4.01351349
39mitotic chromosome condensation (GO:0007076)4.00223384
40negative regulation of T cell mediated immunity (GO:0002710)4.00169150
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.99984546
42response to host immune response (GO:0052572)3.99984546
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.99739375
44pore complex assembly (GO:0046931)3.97704653
45kinetochore organization (GO:0051383)3.92737968
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.88208055
47positive thymic T cell selection (GO:0045059)3.87535824
48hepatocyte apoptotic process (GO:0097284)3.85027677
49detection of biotic stimulus (GO:0009595)3.78411134
50myeloid leukocyte mediated immunity (GO:0002444)3.77982089
51response to host (GO:0075136)3.74940647
52response to host defenses (GO:0052200)3.74940647
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.74940647
54negative regulation of interleukin-12 production (GO:0032695)3.70851848
55negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.66052134
56histone H3-K36 demethylation (GO:0070544)3.61923220
57cellular response to interleukin-15 (GO:0071350)3.60738757
58neutrophil activation involved in immune response (GO:0002283)3.60028303
59phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.59096721
60protein localization to kinetochore (GO:0034501)3.56168581
61regulation of histone H3-K9 methylation (GO:0051570)3.53587752
62meiotic chromosome segregation (GO:0045132)3.49251635
63regulation of RNA export from nucleus (GO:0046831)3.46573717
64positive regulation of granulocyte differentiation (GO:0030854)3.45288521
65negative regulation of B cell proliferation (GO:0030889)3.44791574
66detection of bacterium (GO:0016045)3.40235366
67regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.39775373
68leukocyte aggregation (GO:0070486)3.38867482
69DNA geometric change (GO:0032392)3.38272447
70regulation of B cell differentiation (GO:0045577)3.38085528
71DNA duplex unwinding (GO:0032508)3.37903267
72response to peptidoglycan (GO:0032494)3.37357555
73negative regulation of histone methylation (GO:0031061)3.35860816
74regulation of centriole replication (GO:0046599)3.35236378
75sister chromatid segregation (GO:0000819)3.33530751
76positive regulation of interferon-alpha production (GO:0032727)3.32535916
77translesion synthesis (GO:0019985)3.30698044
78positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30519766
79positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30519766
80positive regulation of mitotic sister chromatid separation (GO:1901970)3.30519766
81respiratory burst (GO:0045730)3.30010176
82T cell migration (GO:0072678)3.29823719
83negative regulation of leukocyte mediated immunity (GO:0002704)3.29389214
84T cell selection (GO:0045058)3.29200761
85protein localization to chromosome, centromeric region (GO:0071459)3.28103253
86mitotic nuclear envelope disassembly (GO:0007077)3.27410860
87myeloid cell activation involved in immune response (GO:0002275)3.26484657
88DNA topological change (GO:0006265)3.26370196
89production of molecular mediator involved in inflammatory response (GO:0002532)3.22488816
90regulation of necroptotic process (GO:0060544)3.22285628
91antigen processing and presentation via MHC class Ib (GO:0002475)3.22265709
92protein localization to chromosome (GO:0034502)3.21895093
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.20044056
94positive regulation of B cell differentiation (GO:0045579)3.19967094
95negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.19713596
96regulation of double-strand break repair via homologous recombination (GO:0010569)3.16759538
97mitotic recombination (GO:0006312)3.16173093
98regulation of sister chromatid cohesion (GO:0007063)3.16160068
99DNA replication initiation (GO:0006270)3.14369885
100activated T cell proliferation (GO:0050798)3.12570109
101regulation of alpha-beta T cell proliferation (GO:0046640)3.12332577
102neutrophil activation (GO:0042119)3.10960588
103negative regulation of DNA-dependent DNA replication (GO:2000104)3.09365161
104DNA replication-independent nucleosome assembly (GO:0006336)3.08255429
105DNA replication-independent nucleosome organization (GO:0034724)3.08255429
106membrane disassembly (GO:0030397)3.08177706
107nuclear envelope disassembly (GO:0051081)3.08177706
108cellular response to type I interferon (GO:0071357)3.05563081
109type I interferon signaling pathway (GO:0060337)3.05563081
110attachment of spindle microtubules to kinetochore (GO:0008608)3.05378023
111positive regulation of gamma-delta T cell activation (GO:0046645)3.05142101
112response to type I interferon (GO:0034340)3.04666870
113regulation of interferon-alpha production (GO:0032647)3.04645291
114interferon-gamma production (GO:0032609)3.00867120
115negative regulation of adaptive immune response (GO:0002820)2.98917341
116regulation of interleukin-12 biosynthetic process (GO:0045075)2.98252639
117thymic T cell selection (GO:0045061)2.98187675
118kinetochore assembly (GO:0051382)2.96519831
119CENP-A containing nucleosome assembly (GO:0034080)2.96349178
120chromatin remodeling at centromere (GO:0031055)2.96347548
121chromatin assembly or disassembly (GO:0006333)2.96192056
122negative regulation of immunoglobulin mediated immune response (GO:0002890)2.95660059
123negative regulation of B cell mediated immunity (GO:0002713)2.95660059
124regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.95363553
125chromatin assembly (GO:0031497)2.94921642
126sister chromatid cohesion (GO:0007062)2.94709202
127defense response to protozoan (GO:0042832)2.94002973
128regulation of double-strand break repair (GO:2000779)2.93944313
129DNA strand elongation involved in DNA replication (GO:0006271)2.92986653
130DNA strand elongation (GO:0022616)2.92500023
131telomere maintenance via recombination (GO:0000722)2.91676701
132monoubiquitinated protein deubiquitination (GO:0035520)2.91312206
133regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90866249
134DNA conformation change (GO:0071103)2.90240995
135positive regulation of chromosome segregation (GO:0051984)2.88940901
136dendritic cell migration (GO:0036336)2.88130282
137regulation of regulatory T cell differentiation (GO:0045589)2.87876224
138telomere maintenance via semi-conservative replication (GO:0032201)2.87791522
139centriole replication (GO:0007099)2.86768585
140response to muramyl dipeptide (GO:0032495)2.86766954
141regulation of chromatin binding (GO:0035561)2.85677734
142mitotic sister chromatid segregation (GO:0000070)2.85355022
143negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85311824
144DNA synthesis involved in DNA repair (GO:0000731)2.82392541
145maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81763080
146tolerance induction (GO:0002507)2.80748776
147positive regulation of interferon-beta production (GO:0032728)2.79673612
148negative regulation of T-helper cell differentiation (GO:0045623)2.78794052
149negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.78794052
150pre-miRNA processing (GO:0031054)2.78081189
151ATP-dependent chromatin remodeling (GO:0043044)2.75590564
152positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75016769
153replication fork processing (GO:0031297)2.72620525
154granulocyte activation (GO:0036230)2.71577020
155regulation of tolerance induction (GO:0002643)2.70268980
156histone H3-K4 trimethylation (GO:0080182)2.70071073
157histone H3-K9 methylation (GO:0051567)2.69880096
158DNA replication-dependent nucleosome assembly (GO:0006335)2.69332050
159DNA replication-dependent nucleosome organization (GO:0034723)2.69332050
160histone mRNA catabolic process (GO:0071044)2.68087787
161regulation of nucleobase-containing compound transport (GO:0032239)2.67818779
162chromosome condensation (GO:0030261)2.67761317
163telomere maintenance (GO:0000723)2.66084854
164regulation of nuclear cell cycle DNA replication (GO:0033262)2.65872436
165regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.65743049
166DNA replication checkpoint (GO:0000076)2.65255844
167regulation of centrosome cycle (GO:0046605)2.64385622
168regulation of centrosome duplication (GO:0010824)2.63178223
169DNA packaging (GO:0006323)2.62515691
170telomere organization (GO:0032200)2.61403590
171metaphase plate congression (GO:0051310)2.60914080
172V(D)J recombination (GO:0033151)2.60669972
173regulation of spindle organization (GO:0090224)2.60242246
174somatic hypermutation of immunoglobulin genes (GO:0016446)2.60225743
175somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60225743
176* dosage compensation (GO:0007549)2.59791014
177regulation of mitotic metaphase/anaphase transition (GO:0030071)2.58507198
178postreplication repair (GO:0006301)2.56068602
179negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54270439
180regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.52609211
181negative regulation of RNA splicing (GO:0033119)2.52473229
182regulation of helicase activity (GO:0051095)2.52082045
183mitotic metaphase plate congression (GO:0007080)2.51793810
184regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.51598991
185chromosome segregation (GO:0007059)2.50325665
186establishment of chromosome localization (GO:0051303)2.49742058
187mRNA stabilization (GO:0048255)2.48965472
188RNA stabilization (GO:0043489)2.48965472
189heterochromatin organization (GO:0070828)2.48697526
190regulation of chromosome segregation (GO:0051983)2.47996880
191nucleotide-excision repair, DNA gap filling (GO:0006297)2.46864403
192telomere maintenance via telomere lengthening (GO:0010833)2.46635274
193spindle assembly checkpoint (GO:0071173)2.45270496
194spindle checkpoint (GO:0031577)2.45095365
195regulation of DNA-dependent DNA replication (GO:0090329)2.44626598
196histone exchange (GO:0043486)2.44229016
197regulation of mitotic sister chromatid segregation (GO:0033047)2.43827670
198regulation of sister chromatid segregation (GO:0033045)2.43827670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.61338322
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.55577746
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.01401468
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.82594899
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73525279
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21697798
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.73475691
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.68974920
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.66886648
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.58554505
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51045920
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49439228
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46409937
14MYC_22102868_ChIP-Seq_BL_Human2.43829184
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.38352316
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.26216101
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14995777
18GATA1_22025678_ChIP-Seq_K562_Human2.14661118
19SPI1_23127762_ChIP-Seq_K562_Human2.10934173
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.01457167
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00417454
22E2F7_22180533_ChIP-Seq_HELA_Human11.5053279
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98345526
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.96951673
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85445486
26* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85375382
27VDR_24787735_ChIP-Seq_THP-1_Human1.84929588
28AR_21909140_ChIP-Seq_LNCAP_Human1.72763813
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71097419
30CIITA_25753668_ChIP-Seq_RAJI_Human1.63568731
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62612812
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61967409
33ELK1_19687146_ChIP-ChIP_HELA_Human1.61720117
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60688215
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60313805
36GATA3_26560356_Chip-Seq_TH2_Human1.57325554
37MYB_26560356_Chip-Seq_TH2_Human1.57191539
38* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54755524
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54679743
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51766958
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49736638
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49652824
43* MYB_26560356_Chip-Seq_TH1_Human1.49449598
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48290396
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46750279
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46423226
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41797525
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38730140
49VDR_21846776_ChIP-Seq_THP-1_Human1.38491039
50* VDR_23849224_ChIP-Seq_CD4+_Human1.38419774
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.37399450
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37294619
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36124433
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34080796
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29286201
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28265275
57FOXP3_21729870_ChIP-Seq_TREG_Human1.28148479
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27682320
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27345324
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24783527
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23669541
62TCF7_22412390_ChIP-Seq_EML_Mouse1.23053049
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21198338
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.20095747
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18841398
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18690807
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17387001
68MAF_26560356_Chip-Seq_TH2_Human1.17096870
69SCL_19346495_ChIP-Seq_HPC-7_Human1.17093751
70SPI1_23547873_ChIP-Seq_NB4_Human1.16660635
71UTX_26944678_Chip-Seq_JUKART_Human1.16112268
72MAF_26560356_Chip-Seq_TH1_Human1.15750599
73KDM5A_27292631_Chip-Seq_BREAST_Human1.15637053
74RUNX_20019798_ChIP-Seq_JUKART_Human1.14808941
75GATA2_19941826_ChIP-Seq_K562_Human1.14807434
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14283997
77GATA1_19941826_ChIP-Seq_K562_Human1.12076796
78* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11300262
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.09511044
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09438700
81* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09082854
82* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08995648
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06430945
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.04835595
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.04102819
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03191885
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02708258
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02518460
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02257197
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01293072
91XRN2_22483619_ChIP-Seq_HELA_Human1.01017192
92KDM2B_26808549_Chip-Seq_DND41_Human1.00578806
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99216979
94PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99053035
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98439815
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98325096
97* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98028209
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98007872
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97730491
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96663121
101* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95302445
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94623635
103RUNX1_22412390_ChIP-Seq_EML_Mouse0.93766889
104TP53_16413492_ChIP-PET_HCT116_Human0.93626902
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.92691263
106SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92527205
107KDM2B_26808549_Chip-Seq_JURKAT_Human0.92335070
108SMRT_27268052_Chip-Seq_Bcells_Human0.91545719
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90149974
110* IRF8_27001747_Chip-Seq_BMDM_Mouse0.89870094
111BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89542564
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89221540
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88948339
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88601292
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88160390
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87930865
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87074970
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.86696372
119EST1_17652178_ChIP-ChIP_JURKAT_Human0.86229236
120TFEB_21752829_ChIP-Seq_HELA_Human0.86085691
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85157262
122GATA3_27048872_Chip-Seq_THYMUS_Human0.83512933
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83311742
124TTF2_22483619_ChIP-Seq_HELA_Human0.83175459
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82696317
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82472011
127* VDR_24763502_ChIP-Seq_THP-1_Human0.82162052
128MYC_18358816_ChIP-ChIP_MESCs_Mouse0.82127121
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82051235
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79928113
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79264739
132ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78783748
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77523453
134LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76648352
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.76646712
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75406048
137* BRD4_25478319_ChIP-Seq_HGPS_Human0.75052738
138CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74498419
139PU_27001747_Chip-Seq_BMDM_Mouse0.73925277
140EWS_26573619_Chip-Seq_HEK293_Human0.72936381
141SALL4_22934838_ChIP-ChIP_CD34+_Human0.72059714
142SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.71837319
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71730450
144KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.70747738
145GATA3_26560356_Chip-Seq_TH1_Human0.70643948
146VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70145676
147CREB1_15753290_ChIP-ChIP_HEK293T_Human0.70059059
148FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69725876
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.68863944
150DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68058528
151* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.67537829
152OCT4_21477851_ChIP-Seq_ESCs_Mouse0.66916897
153PRDM14_20953172_ChIP-Seq_ESCs_Human0.66378904
154CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66371849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.50889433
2MP0008057_abnormal_DNA_replication3.53464991
3MP0008260_abnormal_autophagy3.52174474
4MP0010094_abnormal_chromosome_stability3.42146855
5MP0003303_peritoneal_inflammation3.04270874
6MP0003436_decreased_susceptibility_to2.95759527
7MP0003111_abnormal_nucleus_morphology2.80286594
8MP0008058_abnormal_DNA_repair2.73370140
9MP0002396_abnormal_hematopoietic_system2.70381091
10MP0003693_abnormal_embryo_hatching2.68302471
11MP0003077_abnormal_cell_cycle2.63905799
12MP0002419_abnormal_innate_immunity2.43761708
13MP0010352_gastrointestinal_tract_polyps2.38467754
14MP0004381_abnormal_hair_follicle2.37444738
15MP0000569_abnormal_digit_pigmentation2.37271883
16MP0005451_abnormal_body_composition2.35232345
17MP0005025_abnormal_response_to2.26150855
18MP0003763_abnormal_thymus_physiology2.25413454
19MP0009785_altered_susceptibility_to2.17374509
20MP0008007_abnormal_cellular_replicative2.10367061
21MP0004808_abnormal_hematopoietic_stem2.10173459
22MP0010307_abnormal_tumor_latency2.06454804
23MP0004957_abnormal_blastocyst_morpholog2.03130897
24MP0003656_abnormal_erythrocyte_physiolo1.96339903
25MP0003172_abnormal_lysosome_physiology1.95354475
26MP0004883_abnormal_blood_vessel1.91265955
27MP0002166_altered_tumor_susceptibility1.85494365
28MP0002009_preneoplasia1.85066030
29MP0003828_pulmonary_edema1.82253459
30MP0005076_abnormal_cell_differentiation1.80950995
31MP0003221_abnormal_cardiomyocyte_apopto1.72373713
32MP0002006_tumorigenesis1.71415391
33* MP0003121_genomic_imprinting1.71364803
34MP0008789_abnormal_olfactory_epithelium1.71196976
35MP0003123_paternal_imprinting1.69512045
36MP0000350_abnormal_cell_proliferation1.69323076
37MP0005464_abnormal_platelet_physiology1.66278429
38MP0002398_abnormal_bone_marrow1.64884130
39MP0001835_abnormal_antigen_presentation1.64660514
40MP0000703_abnormal_thymus_morphology1.61522558
41MP0006082_CNS_inflammation1.60001552
42MP0003866_abnormal_defecation1.57570574
43MP0005310_abnormal_salivary_gland1.55253550
44MP0001800_abnormal_humoral_immune1.53242600
45* MP0008877_abnormal_DNA_methylation1.52764196
46MP0004947_skin_inflammation1.52668926
47MP0000490_abnormal_crypts_of1.51117225
48MP0009278_abnormal_bone_marrow1.48929573
49MP0005075_abnormal_melanosome_morpholog1.47217302
50MP0002148_abnormal_hypersensitivity_rea1.46870968
51MP0001845_abnormal_inflammatory_respons1.43435684
52* MP0003787_abnormal_imprinting1.43102122
53MP0003300_gastrointestinal_ulcer1.42692027
54MP0001293_anophthalmia1.39289483
55MP0001730_embryonic_growth_arrest1.38144826
56MP0005380_embryogenesis_phenotype1.37678204
57MP0001672_abnormal_embryogenesis/_devel1.37678204
58MP0001533_abnormal_skeleton_physiology1.36374792
59MP0003191_abnormal_cellular_cholesterol1.34684437
60MP0000858_altered_metastatic_potential1.34080906
61MP0005394_taste/olfaction_phenotype1.32916760
62MP0005499_abnormal_olfactory_system1.32916760
63MP0003984_embryonic_growth_retardation1.32144745
64MP0004197_abnormal_fetal_growth/weight/1.32043333
65MP0002452_abnormal_antigen_presenting1.30732769
66MP0002088_abnormal_embryonic_growth/wei1.30562456
67MP0005164_abnormal_response_to1.30302442
68MP0002132_abnormal_respiratory_system1.30049496
69MP0000689_abnormal_spleen_morphology1.28906533
70MP0008932_abnormal_embryonic_tissue1.27879657
71MP0002722_abnormal_immune_system1.27216068
72MP0001545_abnormal_hematopoietic_system1.27150189
73MP0005397_hematopoietic_system_phenotyp1.27150189
74MP0001851_eye_inflammation1.26827990
75MP0005671_abnormal_response_to1.26809823
76MP0002420_abnormal_adaptive_immunity1.24677322
77* MP0002086_abnormal_extraembryonic_tissu1.22844938
78MP0000716_abnormal_immune_system1.22559986
79MP0001819_abnormal_immune_cell1.22086725
80MP0003567_abnormal_fetal_cardiomyocyte1.20393233
81MP0003890_abnormal_embryonic-extraembry1.19594548
82MP0003183_abnormal_peptide_metabolism1.18279282
83MP0002084_abnormal_developmental_patter1.17125268
84MP0003786_premature_aging1.16239254
85MP0006054_spinal_hemorrhage1.15274188
86MP0002019_abnormal_tumor_incidence1.15266384
87MP0002877_abnormal_melanocyte_morpholog1.14889957
88MP0009764_decreased_sensitivity_to1.14714084
89MP0001697_abnormal_embryo_size1.14422752
90MP0000685_abnormal_immune_system1.13091548
91MP0002085_abnormal_embryonic_tissue1.11489554
92MP0003690_abnormal_glial_cell1.11053622
93MP0002429_abnormal_blood_cell1.10648362
94MP0002723_abnormal_immune_serum1.07682407
95MP0005387_immune_system_phenotype1.05084324
96MP0001790_abnormal_immune_system1.05084324
97MP0009333_abnormal_splenocyte_physiolog1.03939264
98MP0009703_decreased_birth_body1.03808653
99MP0000313_abnormal_cell_death1.02649146
100MP0004484_altered_response_of1.01812272
101MP0004130_abnormal_muscle_cell1.00811346
102MP0000733_abnormal_muscle_development0.99247559
103MP0005174_abnormal_tail_pigmentation0.99168614
104MP0002092_abnormal_eye_morphology0.98547829
105MP0008469_abnormal_protein_level0.98039595
106* MP0002080_prenatal_lethality0.97988697
107MP0010030_abnormal_orbit_morphology0.96468915
108MP0002332_abnormal_exercise_endurance0.94640081
109MP0002405_respiratory_system_inflammati0.94619906
110MP0001853_heart_inflammation0.94380236
111MP0005000_abnormal_immune_tolerance0.93193422
112MP0001873_stomach_inflammation0.92950276
113MP0002277_abnormal_respiratory_mucosa0.91686662
114MP0002998_abnormal_bone_remodeling0.91405216
115MP0003937_abnormal_limbs/digits/tail_de0.90241325
116MP0001915_intracranial_hemorrhage0.87796599
117MP0002095_abnormal_skin_pigmentation0.84754740
118MP0010155_abnormal_intestine_physiology0.83953468
119MP0000432_abnormal_head_morphology0.83548906
120MP0003935_abnormal_craniofacial_develop0.82830407
121MP0002210_abnormal_sex_determination0.82723008
122MP0000465_gastrointestinal_hemorrhage0.82236433
123MP0003705_abnormal_hypodermis_morpholog0.82223039
124MP0002925_abnormal_cardiovascular_devel0.80179144
125MP0000371_diluted_coat_color0.79566531
126MP0001286_abnormal_eye_development0.78731978
127MP0000383_abnormal_hair_follicle0.78689929
128MP0000428_abnormal_craniofacial_morphol0.76631071
129MP0005621_abnormal_cell_physiology0.75481928
130MP0002938_white_spotting0.75423756
131MP0003045_fibrosis0.74919069
132MP0003448_altered_tumor_morphology0.74384187
133MP0000015_abnormal_ear_pigmentation0.73394299
134MP0009763_increased_sensitivity_to0.72739683
135MP0000604_amyloidosis0.71150513
136MP0003091_abnormal_cell_migration0.71031809
137MP0002233_abnormal_nose_morphology0.70924389
138MP0002697_abnormal_eye_size0.70691043
139MP0003566_abnormal_cell_adhesion0.70559811
140MP0003943_abnormal_hepatobiliary_system0.69988762
141MP0005187_abnormal_penis_morphology0.69778065
142MP0002160_abnormal_reproductive_system0.69603742
143MP0003385_abnormal_body_wall0.69442438
144MP0005376_homeostasis/metabolism_phenot0.69209980
145MP0000249_abnormal_blood_vessel0.68746449
146MP0002928_abnormal_bile_duct0.64525529
147MP0001958_emphysema0.61371287
148MP0009765_abnormal_xenobiotic_induced0.59845532
149MP0005408_hypopigmentation0.59431481
150MP0009115_abnormal_fat_cell0.59337779
151MP0002133_abnormal_respiratory_system0.58451861
152MP0005388_respiratory_system_phenotype0.58451861
153MP0001663_abnormal_digestive_system0.58389325
154MP0008874_decreased_physiological_sensi0.53013319
155MP0004264_abnormal_extraembryonic_tissu0.52789942
156MP0000427_abnormal_hair_cycle0.52554833

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.83367758
2Eczematoid dermatitis (HP:0000976)5.57161287
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.41698952
4Recurrent abscess formation (HP:0002722)5.26061909
5Retrobulbar optic neuritis (HP:0100654)4.82039822
6Optic neuritis (HP:0100653)4.82039822
7Orchitis (HP:0100796)4.66739596
8Myositis (HP:0100614)4.62655931
9Gastrointestinal infarctions (HP:0005244)4.46307503
10Volvulus (HP:0002580)4.07941504
11Recurrent gram-negative bacterial infections (HP:0005420)3.83219677
12Recurrent skin infections (HP:0001581)3.80250850
13Gingivitis (HP:0000230)3.78696589
14Chromsome breakage (HP:0040012)3.70728249
15Keratoconjunctivitis sicca (HP:0001097)3.69468901
16Stomatitis (HP:0010280)3.60406956
17Elevated erythrocyte sedimentation rate (HP:0003565)3.60123676
18Recurrent cutaneous fungal infections (HP:0011370)3.59465018
19Chronic mucocutaneous candidiasis (HP:0002728)3.59465018
20Spontaneous hematomas (HP:0007420)3.55839554
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50388323
22Abnormality of the fingertips (HP:0001211)3.40214506
23Keratoconjunctivitis (HP:0001096)3.37092837
24Peritonitis (HP:0002586)3.36125316
25Mediastinal lymphadenopathy (HP:0100721)3.34889278
26Meningitis (HP:0001287)3.33199939
27Gingival bleeding (HP:0000225)3.27901838
28Abnormality of macrophages (HP:0004311)3.27591882
29Arterial thrombosis (HP:0004420)3.26372867
30Encephalitis (HP:0002383)3.23924230
31Vasculitis (HP:0002633)3.13415174
32Chest pain (HP:0100749)3.11352742
33Leukocytosis (HP:0001974)2.99768285
34Short 4th metacarpal (HP:0010044)2.93594317
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93594317
36Chronic obstructive pulmonary disease (HP:0006510)2.90541622
37Obstructive lung disease (HP:0006536)2.90541622
38Viral hepatitis (HP:0006562)2.89061971
39Cellulitis (HP:0100658)2.88603131
40Slow saccadic eye movements (HP:0000514)2.83876335
41Hemoptysis (HP:0002105)2.81919126
42Abnormality of chromosome stability (HP:0003220)2.79750651
43Ectopic kidney (HP:0000086)2.67765398
44Spinal cord lesions (HP:0100561)2.63766290
45Syringomyelia (HP:0003396)2.63766290
46Urticaria (HP:0001025)2.59019011
47Medulloblastoma (HP:0002885)2.58929411
48Eosinophilia (HP:0001880)2.57842106
49Inflammation of the large intestine (HP:0002037)2.56304880
50Pulmonary infiltrates (HP:0002113)2.55499475
51Colitis (HP:0002583)2.55022219
52Granulocytopenia (HP:0001913)2.54628808
53Autoimmune hemolytic anemia (HP:0001890)2.49948499
54Papillary thyroid carcinoma (HP:0002895)2.49616445
55Acute hepatic failure (HP:0006554)2.48654453
56Abnormality of the peritoneum (HP:0002585)2.48119663
57Absent frontal sinuses (HP:0002688)2.46905282
58Epistaxis (HP:0000421)2.46620350
59Increased nuchal translucency (HP:0010880)2.44786446
60Pulmonary embolism (HP:0002204)2.44493950
61Long eyelashes (HP:0000527)2.43495886
62Gastrointestinal inflammation (HP:0004386)2.39798183
63Periodontitis (HP:0000704)2.38816814
64Prominent nose (HP:0000448)2.37953122
65Prolonged bleeding time (HP:0003010)2.37769221
66Abnormality of eosinophils (HP:0001879)2.33173332
67IgM deficiency (HP:0002850)2.32174086
68Myelodysplasia (HP:0002863)2.32161194
69Osteomyelitis (HP:0002754)2.30544496
70Anorexia (HP:0002039)2.30077927
71Deep philtrum (HP:0002002)2.29286568
72Resting tremor (HP:0002322)2.27466870
73Deviation of the thumb (HP:0009603)2.26183103
74Proximal placement of thumb (HP:0009623)2.26048429
75Meckel diverticulum (HP:0002245)2.23598941
76T lymphocytopenia (HP:0005403)2.21483284
77Gangrene (HP:0100758)2.20181339
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.20094811
79Neoplasm of the tracheobronchial system (HP:0100552)2.19359719
80Panhypogammaglobulinemia (HP:0003139)2.19125315
81Patellar aplasia (HP:0006443)2.16373869
82Colon cancer (HP:0003003)2.15576777
83Postural instability (HP:0002172)2.15301164
84Cutis marmorata (HP:0000965)2.15072147
85Acute myeloid leukemia (HP:0004808)2.14102948
86Pustule (HP:0200039)2.13532166
87Abnormality of the ileum (HP:0001549)2.13363774
88Recurrent viral infections (HP:0004429)2.13150773
89Abnormality of T cell number (HP:0011839)2.13109158
90Abnormality of T cell physiology (HP:0011840)2.12559060
91Trigonocephaly (HP:0000243)2.09566435
92Abnormality of the endocardium (HP:0004306)2.09168188
93Papilloma (HP:0012740)2.04927452
94Verrucae (HP:0200043)2.04927452
95Birth length less than 3rd percentile (HP:0003561)2.04675848
96Sepsis (HP:0100806)2.04372037
97Hypoplasia of the thymus (HP:0000778)2.03804231
98Abnormality of the preputium (HP:0100587)2.03329628
99Abnormal number of incisors (HP:0011064)2.03028865
100Stomach cancer (HP:0012126)2.02692804
101Increased IgE level (HP:0003212)2.01545056
102Hypochromic anemia (HP:0001931)2.00968135
103Aplasia/Hypoplasia of the patella (HP:0006498)2.00612403
104Subacute progressive viral hepatitis (HP:0006572)1.99396206
105Episodic fever (HP:0001954)1.99276167
106Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99259530
107Abnormality of the carotid arteries (HP:0005344)1.99172243
108Conjunctival telangiectasia (HP:0000524)1.99169360
109Fatigue (HP:0012378)1.99125178
110Abnormality of the pleura (HP:0002103)1.96940111
111Abnormality of the intervertebral disk (HP:0005108)1.95956189
112Lymphoma (HP:0002665)1.94867067
113Microcytic anemia (HP:0001935)1.93958083
114Keratitis (HP:0000491)1.93843890
115Truncal obesity (HP:0001956)1.93804489
116Selective tooth agenesis (HP:0001592)1.91283441
117Micronodular cirrhosis (HP:0001413)1.91135166
118Supernumerary ribs (HP:0005815)1.90948540
119Recurrent bronchitis (HP:0002837)1.88552468
120Neoplasm of the oral cavity (HP:0100649)1.87861742
121IgA deficiency (HP:0002720)1.87127802
122Glomerulopathy (HP:0100820)1.85982784
123Chronic diarrhea (HP:0002028)1.85916281
124Nephroblastoma (Wilms tumor) (HP:0002667)1.85643543
125Duodenal stenosis (HP:0100867)1.85455020
126Small intestinal stenosis (HP:0012848)1.85455020
127IgG deficiency (HP:0004315)1.84233240
128Abnormality of the 4th metacarpal (HP:0010012)1.83580613
129Basal cell carcinoma (HP:0002671)1.83436581
130Lip pit (HP:0100267)1.82993172
131Increased density of long bones (HP:0006392)1.82155535
132Rhabdomyosarcoma (HP:0002859)1.81666685
133Heterotopia (HP:0002282)1.81496035
134Thrombophlebitis (HP:0004418)1.80300422
135Mesomelia (HP:0003027)1.79691153
136Prostate neoplasm (HP:0100787)1.79534608
137Asymmetry of the thorax (HP:0001555)1.78700678
138Impulsivity (HP:0100710)1.78696917
139Thrombocytosis (HP:0001894)1.78580355
140Gastrointestinal carcinoma (HP:0002672)1.76984375
141Malignant gastrointestinal tract tumors (HP:0006749)1.76984375
142Abnormality of the nasal septum (HP:0000419)1.76504297
143Thyroiditis (HP:0100646)1.76370180
144Aplasia/Hypoplasia of the thymus (HP:0010515)1.75947904
145High pitched voice (HP:0001620)1.75623195
146Skin ulcer (HP:0200042)1.74434015
147Alveolar cell carcinoma (HP:0006519)1.74318605
148Clubbing of toes (HP:0100760)1.74210238
149Atresia of the external auditory canal (HP:0000413)1.73939473
150B lymphocytopenia (HP:0010976)1.73798308
151Abnormality of B cell number (HP:0010975)1.73798308
152Supernumerary bones of the axial skeleton (HP:0009144)1.72683723
153Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72481087
154Transitional cell carcinoma of the bladder (HP:0006740)1.71261232
155Cutaneous melanoma (HP:0012056)1.71192791
156Limited elbow extension (HP:0001377)1.70476790
157Embryonal renal neoplasm (HP:0011794)1.69837787
158Abnormality of the labia minora (HP:0012880)1.68664640
159Aplasia/Hypoplasia of the earlobes (HP:0009906)1.68077829
160Abnormality of cells of the lymphoid lineage (HP:0012140)1.67976066
161Facial hemangioma (HP:0000329)1.67460767
162Lymphopenia (HP:0001888)1.67360770
163Neoplasm of the adrenal cortex (HP:0100641)1.67242199
164Sloping forehead (HP:0000340)1.67136243
165Vertebral arch anomaly (HP:0008438)1.67082134
166Sandal gap (HP:0001852)1.66027925
167Aplasia/Hypoplasia of the sternum (HP:0006714)1.65963954
168Hypochromic microcytic anemia (HP:0004840)1.65004897
169Obsessive-compulsive behavior (HP:0000722)1.64532215
170Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64236224
171Cafe-au-lait spot (HP:0000957)1.63298737
172Skull defect (HP:0001362)1.63190624
173Abnormality of T cells (HP:0002843)1.63105141
174Dislocated radial head (HP:0003083)1.62969234
175Amaurosis fugax (HP:0100576)1.61523030
176Abnormal delayed hypersensitivity skin test (HP:0002963)1.61300825
177Hematochezia (HP:0002573)1.61268303
178Thick eyebrow (HP:0000574)1.61207114
179Long clavicles (HP:0000890)1.60907921
180Abnormality of the prostate (HP:0008775)1.60700518
181Recurrent fungal infections (HP:0002841)1.60576901
182Microtia (HP:0008551)1.59984739
183Broad palm (HP:0001169)1.57840658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.16115922
2RIPK44.06853092
3CDK123.48340136
4ERBB33.20337872
5PLK43.14412054
6NEK22.74981148
7BRD42.40640719
8SRPK12.27122112
9MAP4K12.16184506
10EEF2K2.09934876
11FES2.02641593
12ACVR1B1.94640317
13FGR1.92681048
14MAP3K101.92168604
15MAP3K21.89323362
16ZAK1.80798292
17TAOK31.77489625
18ATR1.75430920
19MKNK11.70652445
20TTK1.70210587
21JAK31.69972602
22IRAK11.69419072
23STK101.65265822
24PRPF4B1.62551947
25BMPR21.58569699
26RPS6KA41.58545710
27STK41.58076031
28PIK3CG1.58067641
29CDK61.54889574
30CDK41.49921706
31MKNK21.46599011
32NUAK11.43194584
33TXK1.42982464
34FGFR31.42539920
35JAK21.42083072
36IRAK21.41916260
37WNK11.41688573
38AURKB1.33468905
39STK31.32973895
40PASK1.32708229
41FGFR41.32212132
42KSR21.30541562
43CHEK21.29608827
44EPHB11.28774768
45WEE11.28272834
46SGK21.26860074
47SIK21.25519475
48PLK11.24974357
49CHEK11.23036701
50PIM11.22963450
51LYN1.22607923
52RPS6KB21.20107559
53CDK91.18531978
54CAMKK21.15892207
55CLK11.15556021
56MAP3K11.14909534
57MAP3K131.14075498
58MAP3K141.13151634
59SGK31.09562391
60CSF1R1.09488041
61PLK31.09018795
62MAP3K61.08958950
63ATM1.08946737
64DYRK31.06800519
65IRAK41.06341217
66MELK1.05256383
67MARK21.05231434
68TGFBR11.01260925
69CHUK1.00354173
70PTK2B0.98548783
71CDK70.98299152
72TYK20.95253450
73RAF10.91432234
74TEC0.91268806
75GRK60.90648873
76CAMK1D0.90446653
77KSR10.88452886
78BTK0.87998638
79LATS10.84822381
80TLK10.84339153
81ITK0.83813817
82TTN0.82734283
83TRPM70.82611467
84PKN20.81943433
85CDK20.81842541
86BRSK20.81044484
87MAP3K30.80870419
88FRK0.79129364
89NEK90.78842627
90TGFBR20.78531363
91MARK30.77345524
92MAP3K80.75498555
93MATK0.73616291
94TNK20.73404952
95TBK10.71527465
96VRK10.70338453
97JAK10.69999727
98PDK10.68309028
99SCYL20.68179054
100RET0.65965741
101TAOK10.65068000
102CDK10.64955684
103CAMK1G0.64951843
104STK110.63673269
105IKBKE0.62896125
106LCK0.62890078
107MAP3K50.61583139
108SGK4940.61193973
109SGK2230.61193973
110ERBB20.60324419
111NEK60.59755305
112YES10.59654985
113ERN10.59443740
114ZAP700.59184954
115RPS6KA50.58831227
116MTOR0.58831132
117GRK50.58717505
118HCK0.58421542
119EIF2AK20.58354892
120NLK0.58316261
121EPHA30.58288517
122CAMKK10.57191569
123DYRK1A0.56303750
124AKT30.55925312
125KIT0.55705156
126MAP3K70.53530911
127CSK0.53257723
128HIPK20.53116971
129ALK0.51943676
130BLK0.51754311
131MAP2K40.51395342
132LRRK20.50464038
133IKBKB0.50153324
134STK380.50126292
135SGK10.49380077
136EIF2AK30.48752980
137CAMK40.48302184
138TSSK60.48212338
139MAPK140.47983873
140EIF2AK10.47600235
141DYRK1B0.47393596
142PTK60.46937116
143EGFR0.46792791
144MAP2K30.46755773
145FYN0.46726117
146CSNK1A1L0.46397682
147RIPK10.45273170
148FLT30.43313285
149RPS6KB10.43100866
150PRKDC0.42662417
151PRKCQ0.41838260
152SYK0.40476055
153AKT10.40108634
154FGFR20.39425673
155PDGFRB0.39042144

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.11379175
2Mismatch repair_Homo sapiens_hsa034302.71127643
3Cell cycle_Homo sapiens_hsa041102.34864991
4Non-homologous end-joining_Homo sapiens_hsa034502.33849121
5Fanconi anemia pathway_Homo sapiens_hsa034602.25230216
6Base excision repair_Homo sapiens_hsa034102.11144904
7Spliceosome_Homo sapiens_hsa030402.01536867
8Homologous recombination_Homo sapiens_hsa034401.99965079
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92669745
10Primary immunodeficiency_Homo sapiens_hsa053401.85667588
11RNA transport_Homo sapiens_hsa030131.84976465
12Systemic lupus erythematosus_Homo sapiens_hsa053221.84055701
13Staphylococcus aureus infection_Homo sapiens_hsa051501.77137753
14mRNA surveillance pathway_Homo sapiens_hsa030151.69401593
15Nucleotide excision repair_Homo sapiens_hsa034201.65489181
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.61640798
17Herpes simplex infection_Homo sapiens_hsa051681.60370544
18One carbon pool by folate_Homo sapiens_hsa006701.51839896
19p53 signaling pathway_Homo sapiens_hsa041151.50250045
20Viral carcinogenesis_Homo sapiens_hsa052031.49742036
21RNA degradation_Homo sapiens_hsa030181.48603316
22Measles_Homo sapiens_hsa051621.44032289
23B cell receptor signaling pathway_Homo sapiens_hsa046621.42224239
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40942091
25MicroRNAs in cancer_Homo sapiens_hsa052061.38738028
26Chronic myeloid leukemia_Homo sapiens_hsa052201.38167073
27Small cell lung cancer_Homo sapiens_hsa052221.34947924
28HTLV-I infection_Homo sapiens_hsa051661.28675121
29Dorso-ventral axis formation_Homo sapiens_hsa043201.26670099
30Antigen processing and presentation_Homo sapiens_hsa046121.26496559
31T cell receptor signaling pathway_Homo sapiens_hsa046601.26260305
32Renal cell carcinoma_Homo sapiens_hsa052111.25086363
33Hepatitis B_Homo sapiens_hsa051611.21786163
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19849643
35Viral myocarditis_Homo sapiens_hsa054161.18628531
36Epstein-Barr virus infection_Homo sapiens_hsa051691.18148885
37Colorectal cancer_Homo sapiens_hsa052101.17287334
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.16142527
39Adherens junction_Homo sapiens_hsa045201.12975571
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10254626
41Pancreatic cancer_Homo sapiens_hsa052121.09545135
42VEGF signaling pathway_Homo sapiens_hsa043701.09452425
43Hematopoietic cell lineage_Homo sapiens_hsa046401.09216993
44Leishmaniasis_Homo sapiens_hsa051401.07086589
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05994332
46Basal transcription factors_Homo sapiens_hsa030221.04625357
47Notch signaling pathway_Homo sapiens_hsa043301.04141159
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03465847
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01796995
50Influenza A_Homo sapiens_hsa051641.01014948
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00746292
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00128530
53Type I diabetes mellitus_Homo sapiens_hsa049400.99063818
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96798393
55Apoptosis_Homo sapiens_hsa042100.96540963
56Non-small cell lung cancer_Homo sapiens_hsa052230.95672619
57Prostate cancer_Homo sapiens_hsa052150.94988049
58Osteoclast differentiation_Homo sapiens_hsa043800.94086269
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.92959706
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.92676370
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91963357
62Toxoplasmosis_Homo sapiens_hsa051450.91452643
63Acute myeloid leukemia_Homo sapiens_hsa052210.91373245
64FoxO signaling pathway_Homo sapiens_hsa040680.90965512
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89915066
66Alcoholism_Homo sapiens_hsa050340.89833719
67ErbB signaling pathway_Homo sapiens_hsa040120.87249708
68TNF signaling pathway_Homo sapiens_hsa046680.85999185
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84385627
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83533757
71Choline metabolism in cancer_Homo sapiens_hsa052310.82071824
72Allograft rejection_Homo sapiens_hsa053300.81010254
73Pyrimidine metabolism_Homo sapiens_hsa002400.80470064
74TGF-beta signaling pathway_Homo sapiens_hsa043500.80054501
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80028875
76RNA polymerase_Homo sapiens_hsa030200.79030856
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78863962
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.78767120
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78711112
80Phagosome_Homo sapiens_hsa041450.77099864
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76730544
82Shigellosis_Homo sapiens_hsa051310.76344542
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75556917
84HIF-1 signaling pathway_Homo sapiens_hsa040660.74509503
85Endometrial cancer_Homo sapiens_hsa052130.74423316
86Pathways in cancer_Homo sapiens_hsa052000.74128409
87Graft-versus-host disease_Homo sapiens_hsa053320.73781504
88Proteoglycans in cancer_Homo sapiens_hsa052050.72992668
89Lysine degradation_Homo sapiens_hsa003100.72630959
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72500789
91African trypanosomiasis_Homo sapiens_hsa051430.71381147
92Hepatitis C_Homo sapiens_hsa051600.71077466
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70555030
94Chemokine signaling pathway_Homo sapiens_hsa040620.70387793
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69994754
96mTOR signaling pathway_Homo sapiens_hsa041500.69913901
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.69883682
98GnRH signaling pathway_Homo sapiens_hsa049120.68103353
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.67808620
100Legionellosis_Homo sapiens_hsa051340.66172074
101Insulin resistance_Homo sapiens_hsa049310.65542837
102Long-term potentiation_Homo sapiens_hsa047200.65157925
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64984554
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64788476
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.64348742
106Platelet activation_Homo sapiens_hsa046110.64252284
107Prolactin signaling pathway_Homo sapiens_hsa049170.64172535
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64062831
109Basal cell carcinoma_Homo sapiens_hsa052170.63098321
110Autoimmune thyroid disease_Homo sapiens_hsa053200.62627127
111Type II diabetes mellitus_Homo sapiens_hsa049300.62264526
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61633865
113Asthma_Homo sapiens_hsa053100.61426007
114Thyroid cancer_Homo sapiens_hsa052160.59824565
115Oocyte meiosis_Homo sapiens_hsa041140.58607014
116MAPK signaling pathway_Homo sapiens_hsa040100.56980638
117Pertussis_Homo sapiens_hsa051330.56435688
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56401610
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55521830
120Tuberculosis_Homo sapiens_hsa051520.55434798
121Salmonella infection_Homo sapiens_hsa051320.55207185
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53853794
123Glioma_Homo sapiens_hsa052140.53195447
124Focal adhesion_Homo sapiens_hsa045100.51208830
125Hippo signaling pathway_Homo sapiens_hsa043900.51119251
126Wnt signaling pathway_Homo sapiens_hsa043100.50256090
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50158640
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49505876
129Amoebiasis_Homo sapiens_hsa051460.48099154
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48076583
131Inositol phosphate metabolism_Homo sapiens_hsa005620.47375433
132Estrogen signaling pathway_Homo sapiens_hsa049150.47159484
133Endocytosis_Homo sapiens_hsa041440.46844193
134Ribosome_Homo sapiens_hsa030100.46336008
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46103762
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45798078
137Malaria_Homo sapiens_hsa051440.44784242

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