SMCO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.88592516
2reproduction (GO:0000003)9.77636458
3epithelial cilium movement (GO:0003351)9.47762721
4spermatid development (GO:0007286)9.20229101
5piRNA metabolic process (GO:0034587)8.79877282
6male meiosis (GO:0007140)8.78064503
7motile cilium assembly (GO:0044458)8.60787430
8regulation of cilium movement (GO:0003352)8.45829035
9cilium movement (GO:0003341)8.40933056
10synaptonemal complex assembly (GO:0007130)8.05831791
11synaptonemal complex organization (GO:0070193)8.03268332
12sperm capacitation (GO:0048240)7.94859246
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.93598353
14single fertilization (GO:0007338)7.56763829
15fertilization (GO:0009566)6.33342813
16negative regulation of inclusion body assembly (GO:0090084)6.23569773
17ribosomal small subunit biogenesis (GO:0042274)6.23195593
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.22726643
19spermatogenesis (GO:0007283)6.14884286
20male gamete generation (GO:0048232)6.12824889
21substrate-independent telencephalic tangential migration (GO:0021826)5.92514942
22substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.92514942
23respiratory tube development (GO:0030323)5.76160323
24gamete generation (GO:0007276)5.64250087
25organic cation transport (GO:0015695)5.63491246
26chromosome organization involved in meiosis (GO:0070192)5.63164224
27microtubule severing (GO:0051013)5.63108701
28ventricular system development (GO:0021591)5.58819653
29DNA methylation involved in gamete generation (GO:0043046)5.52736371
30muscle organ morphogenesis (GO:0048644)5.39464777
31microtubule depolymerization (GO:0007019)5.37789523
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.34250586
33cell recognition (GO:0008037)5.26357014
34outer ear morphogenesis (GO:0042473)5.25089699
35male meiosis I (GO:0007141)5.23774193
36heterochromatin organization (GO:0070828)5.22696931
37germ cell development (GO:0007281)5.19768940
38regulation of inclusion body assembly (GO:0090083)5.13802184
39pyrimidine nucleotide catabolic process (GO:0006244)5.12847800
40protein maturation by protein folding (GO:0022417)5.11101709
41spermatid nucleus differentiation (GO:0007289)5.09100173
42calcium ion-dependent exocytosis (GO:0017156)5.04229737
43regulation of microtubule-based movement (GO:0060632)4.97436777
44meiotic nuclear division (GO:0007126)4.91607075
45tooth mineralization (GO:0034505)4.67137062
46protein polyglutamylation (GO:0018095)4.59604931
47response to redox state (GO:0051775)4.55893809
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.50741472
49chromatin remodeling at centromere (GO:0031055)4.48052223
50seminiferous tubule development (GO:0072520)4.44227203
51multicellular organismal reproductive process (GO:0048609)4.42537414
52deoxyribonucleotide catabolic process (GO:0009264)4.41372971
53striatum development (GO:0021756)4.37323200
54viral transcription (GO:0019083)4.35355505
55deoxyribose phosphate catabolic process (GO:0046386)4.31780892
56translational termination (GO:0006415)4.22689210
57meiosis I (GO:0007127)4.21696076
58monoubiquitinated protein deubiquitination (GO:0035520)4.05319516
59chromosome condensation (GO:0030261)4.05177586
60base-excision repair, AP site formation (GO:0006285)4.04917355
61ribosomal large subunit biogenesis (GO:0042273)4.01381354
62cardiac left ventricle morphogenesis (GO:0003214)3.99264504
63CENP-A containing nucleosome assembly (GO:0034080)3.99086902
64maturation of SSU-rRNA (GO:0030490)3.98315367
65DNA synthesis involved in DNA repair (GO:0000731)3.97239004
66chaperone-mediated protein transport (GO:0072321)3.96859310
67glycerol ether metabolic process (GO:0006662)3.85646615
68reciprocal DNA recombination (GO:0035825)3.85305185
69reciprocal meiotic recombination (GO:0007131)3.85305185
70ribonucleoprotein complex biogenesis (GO:0022613)3.82399221
71DNA packaging (GO:0006323)3.81375023
72left/right pattern formation (GO:0060972)3.80291189
73meiotic cell cycle (GO:0051321)3.76108509
74chaperone-mediated protein complex assembly (GO:0051131)3.75802359
75protein localization to cilium (GO:0061512)3.74105049
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68213052
77endocardial cushion development (GO:0003197)3.60783336
78genitalia morphogenesis (GO:0035112)3.60673667
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59656386
80multicellular organismal development (GO:0007275)3.57308620
81ether metabolic process (GO:0018904)3.55798581
82negative regulation of mast cell activation (GO:0033004)3.53165678
83histone exchange (GO:0043486)3.51400489
84synapsis (GO:0007129)3.51270510
85cotranslational protein targeting to membrane (GO:0006613)3.50039358
86polarized epithelial cell differentiation (GO:0030859)3.49489871
87protein targeting to ER (GO:0045047)3.47493525
88rRNA processing (GO:0006364)3.42374148
89termination of RNA polymerase III transcription (GO:0006386)3.40361970
90transcription elongation from RNA polymerase III promoter (GO:0006385)3.40361970
91intraciliary transport (GO:0042073)3.40333988
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37557541
93mitochondrial respiratory chain complex I assembly (GO:0032981)3.37557541
94NADH dehydrogenase complex assembly (GO:0010257)3.37557541
95cellular component biogenesis (GO:0044085)3.36708618
96protein targeting to mitochondrion (GO:0006626)3.34939725
97lung lobe morphogenesis (GO:0060463)3.33769806
98translational elongation (GO:0006414)3.33225220
99translational initiation (GO:0006413)3.33028074
100cellular protein complex disassembly (GO:0043624)3.30178069
101spliceosomal snRNP assembly (GO:0000387)3.28742640
102establishment of protein localization to endoplasmic reticulum (GO:0072599)3.27885571
103replication fork processing (GO:0031297)3.27410680
104negative regulation of organelle assembly (GO:1902116)3.24711907
105establishment of protein localization to mitochondrial membrane (GO:0090151)3.24622488
106gene silencing by RNA (GO:0031047)3.23825226
107regulation of spindle checkpoint (GO:0090231)3.23492987
108protein localization to endoplasmic reticulum (GO:0070972)3.22324645
109amino-acid betaine transport (GO:0015838)3.21466094
110carnitine transport (GO:0015879)3.21466094
111purine deoxyribonucleotide catabolic process (GO:0009155)3.20763026
112translation (GO:0006412)3.18828868
113meiotic cell cycle process (GO:1903046)3.18673125
114rRNA metabolic process (GO:0016072)3.18488128
115DNA replication-dependent nucleosome organization (GO:0034723)3.17476930
116DNA replication-dependent nucleosome assembly (GO:0006335)3.17476930
117DNA replication-independent nucleosome assembly (GO:0006336)3.17104684
118DNA replication-independent nucleosome organization (GO:0034724)3.17104684
119carnitine transmembrane transport (GO:1902603)3.16881654
120microtubule-based movement (GO:0007018)3.15007735
121grooming behavior (GO:0007625)3.14461406
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12795955
123lung vasculature development (GO:0060426)3.11778680
124protein K11-linked deubiquitination (GO:0035871)3.11462517
125cardiovascular system development (GO:0072358)3.11104983
126viral life cycle (GO:0019058)3.10890815
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07509423
128chromatin assembly (GO:0031497)3.06734786
129single strand break repair (GO:0000012)3.04186373
130histone mRNA metabolic process (GO:0008334)3.02529343
131glyoxylate metabolic process (GO:0046487)2.99653495
132ribosome biogenesis (GO:0042254)2.99106166
133regulation of centriole replication (GO:0046599)2.97855491
134cilium organization (GO:0044782)2.97679509
135sphingomyelin metabolic process (GO:0006684)2.94933610
136tryptophan catabolic process (GO:0006569)2.93337418
137indole-containing compound catabolic process (GO:0042436)2.93337418
138indolalkylamine catabolic process (GO:0046218)2.93337418
139axoneme assembly (GO:0035082)2.91916868
140mitochondrial respiratory chain complex assembly (GO:0033108)2.91181110
141establishment of protein localization to mitochondrion (GO:0072655)2.90141166
142guanosine-containing compound biosynthetic process (GO:1901070)2.89845338
143cellular component assembly involved in morphogenesis (GO:0010927)2.88559578
144kinetochore organization (GO:0051383)2.88178010
145peptidyl-glutamic acid modification (GO:0018200)2.87408657
146chromatin assembly or disassembly (GO:0006333)2.87301848
147kynurenine metabolic process (GO:0070189)2.85842938
148nucleoside diphosphate phosphorylation (GO:0006165)2.85602875
1492-deoxyribonucleotide metabolic process (GO:0009394)2.84839502
150response to parathyroid hormone (GO:0071107)2.84022988
151protein localization to mitochondrion (GO:0070585)2.83328185
152cilium assembly (GO:0042384)2.82009067
153cilium morphogenesis (GO:0060271)2.77571091
154lactate metabolic process (GO:0006089)2.77322906
155microtubule polymerization or depolymerization (GO:0031109)2.75126465
156positive regulation of macrophage activation (GO:0043032)2.73345355
157alditol metabolic process (GO:0019400)2.72984500
158protein refolding (GO:0042026)2.70940019
159interferon-gamma secretion (GO:0072643)2.70235595
160mitotic sister chromatid cohesion (GO:0007064)2.69962203
161nucleus organization (GO:0006997)2.69436122
162glycolytic process (GO:0006096)2.67902655
163polyol catabolic process (GO:0046174)2.65434976
164GTP biosynthetic process (GO:0006183)2.63341176
165sexual reproduction (GO:0019953)2.53398623
166gene silencing (GO:0016458)2.51962195
167centriole replication (GO:0007099)2.51322382
168centriole assembly (GO:0098534)2.47325537
169calcium ion import (GO:0070509)2.45655308
170peptidyl-lysine dimethylation (GO:0018027)2.43234451
171nuclear pore complex assembly (GO:0051292)2.41960243
172sequestering of actin monomers (GO:0042989)2.36483587
173acrosome assembly (GO:0001675)13.1727506
174fusion of sperm to egg plasma membrane (GO:0007342)12.9980470
175cilium or flagellum-dependent cell motility (GO:0001539)12.9672859
176sperm motility (GO:0030317)12.8748134
177cell wall macromolecule metabolic process (GO:0044036)12.2601128
178cell wall macromolecule catabolic process (GO:0016998)12.2601128
179sperm-egg recognition (GO:0035036)12.0933828
180multicellular organism reproduction (GO:0032504)11.8456155
181acrosome reaction (GO:0007340)10.9342635
182cell-cell recognition (GO:0009988)10.8365477
183binding of sperm to zona pellucida (GO:0007339)10.7229445
184axonemal dynein complex assembly (GO:0070286)10.1848942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.72293406
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.83189015
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.73274292
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.69220972
5EZH2_22144423_ChIP-Seq_EOC_Human4.63085829
6MYC_18555785_ChIP-Seq_MESCs_Mouse4.55489705
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.99470981
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.52107431
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.40580873
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.36806172
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30960250
12E2F7_22180533_ChIP-Seq_HELA_Human3.18748849
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.18560804
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15797523
15BP1_19119308_ChIP-ChIP_Hs578T_Human3.02650759
16DCP1A_22483619_ChIP-Seq_HELA_Human3.00486215
17CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00458733
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95690898
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75225689
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69280635
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.64683599
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60667686
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.44630358
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41288984
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.35777386
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.34550091
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.31833785
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27382019
29GABP_19822575_ChIP-Seq_HepG2_Human2.26909864
30CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.26662438
31PCGF2_27294783_Chip-Seq_ESCs_Mouse2.26607008
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22018224
33TP63_17297297_ChIP-ChIP_HaCaT_Human2.20522776
34VDR_22108803_ChIP-Seq_LS180_Human2.18355509
35XRN2_22483619_ChIP-Seq_HELA_Human2.15692465
36ZNF274_21170338_ChIP-Seq_K562_Hela2.12641411
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.10511949
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06976826
39GATA1_26923725_Chip-Seq_HPCs_Mouse2.06024584
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05198799
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02271584
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01721022
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99630909
44KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.98018919
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97758105
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94582731
47TTF2_22483619_ChIP-Seq_HELA_Human1.94263088
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93381327
49AR_21909140_ChIP-Seq_LNCAP_Human1.93082442
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86695752
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85636150
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84454674
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83626917
54VDR_23849224_ChIP-Seq_CD4+_Human1.83281861
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.79647142
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.76745781
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.74478299
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.72429373
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71944341
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71817857
61ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70448127
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.69985951
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.63687744
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.63485277
65FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62029917
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61894006
67STAT1_17558387_ChIP-Seq_HELA_Human1.61886722
68GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.59341671
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58713198
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.57815814
71FOXP3_21729870_ChIP-Seq_TREG_Human1.56955447
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.55643737
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55282008
74GATA3_21867929_ChIP-Seq_CD8_Mouse1.50732745
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48039749
76CBP_20019798_ChIP-Seq_JUKART_Human1.46740626
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46740626
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46394133
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46018856
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46018856
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46018856
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45458446
83KDM2B_26808549_Chip-Seq_REH_Human1.44650765
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.42930382
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39515679
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39443107
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.37955805
88SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37298102
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36179456
90RNF2_27304074_Chip-Seq_NSC_Mouse1.31944299
91LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31518102
92WDR5_24793694_ChIP-Seq_LNCAP_Human1.31343633
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31313781
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31036548
95GATA3_21867929_ChIP-Seq_TH1_Mouse1.30487506
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30134515
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29786267
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28936596
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27776131
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.26969902
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25427240
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25199492
103RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24275350
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.23368293
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.22748281
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21856240
107BCL6_27268052_Chip-Seq_Bcells_Human1.20411942
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20401758
109GF1_26923725_Chip-Seq_HPCs_Mouse1.19985120
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19749399
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18552885
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.17645535
113TP53_22573176_ChIP-Seq_HFKS_Human1.16592205
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16256917
115REST_21632747_ChIP-Seq_MESCs_Mouse1.15687839
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15332043
117ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15285433
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.15130087
119FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15041149
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14433637
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.14254134
122SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14111628
123FUS_26573619_Chip-Seq_HEK293_Human1.13858162
124P300_18555785_Chip-Seq_ESCs_Mouse1.13811121
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12990462
126P53_22387025_ChIP-Seq_ESCs_Mouse1.12985898
127FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12663025
128P53_21459846_ChIP-Seq_SAOS-2_Human1.12548679
129EZH2_27304074_Chip-Seq_ESCs_Mouse1.11955024
130CMYC_18555785_Chip-Seq_ESCs_Mouse1.10040448
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10019643
132SPI1_26923725_Chip-Seq_HPCs_Mouse1.09913604
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09148893
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08112194
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07230896
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07230896
137NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06598029
138SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06373948
139ELK1_19687146_ChIP-ChIP_HELA_Human1.06333188
140ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05749367
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05452715
142STAT3_18555785_Chip-Seq_ESCs_Mouse1.03327703
143RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03092804
144P300_27268052_Chip-Seq_Bcells_Human1.03083625
145FOXP1_21924763_ChIP-Seq_HESCs_Human1.02960637
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02895892
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02849351
148EED_16625203_ChIP-ChIP_MESCs_Mouse1.01204173
149RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01201574
150ESET_19884257_ChIP-Seq_ESCs_Mouse1.00729682
151CTCF_18555785_Chip-Seq_ESCs_Mouse1.00211431
152RARA_24833708_ChIP-Seq_LIVER_Mouse1.00113147
153RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98974159
154RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98644598
155CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98493160
156SOX2_18555785_Chip-Seq_ESCs_Mouse0.96876230
157SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95980865
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95630278
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95443700
160PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95041155
161PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94316945
162PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94231593
163NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93472895
164PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93363223
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93098538
166TP53_20018659_ChIP-ChIP_R1E_Mouse0.93066842
167ERG_20517297_ChIP-Seq_VCAP_Human0.92942211
168RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92844576
169YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92278819
170RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92073039
171PU1_27457419_Chip-Seq_LIVER_Mouse0.92013709
172PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91872375
173LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91795326
174ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91082814
175ELF1_20517297_ChIP-Seq_JURKAT_Human0.90750637
176SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90524198
177EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90378964
178E2F1_18555785_Chip-Seq_ESCs_Mouse0.90210382
179TFEB_21752829_ChIP-Seq_HELA_Human0.90199782
180GF1B_26923725_Chip-Seq_HPCs_Mouse0.90130035
181FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89846166
182YY1_22570637_ChIP-Seq_MALME-3M_Human0.89802580
183POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89712341
184ZFX_18555785_Chip-Seq_ESCs_Mouse0.89592158
185PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89303466
186TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86896759
187P68_20966046_ChIP-Seq_HELA_Human0.85239781
188TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85173487
189SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82200648
190JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81984144
191PHF8_20622854_ChIP-Seq_HELA_Human0.79735010
192SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78166765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02395108
2MP0003123_paternal_imprinting5.86892655
3MP0001929_abnormal_gametogenesis5.57489923
4MP0008877_abnormal_DNA_methylation4.90864135
5MP0002653_abnormal_ependyma_morphology3.77589276
6MP0002877_abnormal_melanocyte_morpholog3.73710132
7MP0000678_abnormal_parathyroid_gland3.73681970
8MP0002210_abnormal_sex_determination3.65754940
9MP0003806_abnormal_nucleotide_metabolis3.60909601
10MP0005423_abnormal_somatic_nervous3.54488392
11MP0002161_abnormal_fertility/fecundity3.27106566
12MP0005499_abnormal_olfactory_system3.22537395
13MP0005394_taste/olfaction_phenotype3.22537395
14MP0001145_abnormal_male_reproductive3.11163088
15MP0000653_abnormal_sex_gland2.73152989
16MP0005623_abnormal_meninges_morphology2.59765434
17MP0003693_abnormal_embryo_hatching2.54740306
18MP0001188_hyperpigmentation2.34186079
19MP0000579_abnormal_nail_morphology2.28462021
20MP0002277_abnormal_respiratory_mucosa2.23756480
21MP0009379_abnormal_foot_pigmentation2.09044729
22MP0001348_abnormal_lacrimal_gland2.00915473
23MP0005410_abnormal_fertilization15.5968382
24MP0009840_abnormal_foam_cell1.96837131
25MP0003186_abnormal_redox_activity1.96187202
26MP0002163_abnormal_gland_morphology1.93782703
27MP0005670_abnormal_white_adipose1.90964605
28MP0005379_endocrine/exocrine_gland_phen1.89104533
29MP0008789_abnormal_olfactory_epithelium1.88692542
30MP0003646_muscle_fatigue1.85194453
31MP0009046_muscle_twitch1.80707125
32MP0001661_extended_life_span1.72993749
33MP0001879_abnormal_lymphatic_vessel1.71206040
34MP0000467_abnormal_esophagus_morphology1.65463037
35MP0008058_abnormal_DNA_repair1.63239671
36MP0002796_impaired_skin_barrier1.57212877
37MP0009053_abnormal_anal_canal1.50628170
38MP0002282_abnormal_trachea_morphology1.50185703
39MP0005275_abnormal_skin_tensile1.46613073
40MP0002095_abnormal_skin_pigmentation1.44886199
41MP0002249_abnormal_larynx_morphology1.43670828
42MP0002160_abnormal_reproductive_system1.41767440
43MP0002177_abnormal_outer_ear1.40627965
44MP0000049_abnormal_middle_ear1.40397225
45MP0008057_abnormal_DNA_replication1.27151394
46MP0004782_abnormal_surfactant_physiolog1.26634939
47MP0005409_darkened_coat_color1.25135114
48MP0003315_abnormal_perineum_morphology1.24006979
49MP0004233_abnormal_muscle_weight1.22796504
50MP0005501_abnormal_skin_physiology1.22302504
51MP0003121_genomic_imprinting1.15624272
52MP0000749_muscle_degeneration1.11198047
53MP0001984_abnormal_olfaction1.10354712
54MP0000681_abnormal_thyroid_gland1.03597632
55MP0002932_abnormal_joint_morphology1.02290907
56MP0005647_abnormal_sex_gland1.00987484
57MP0010094_abnormal_chromosome_stability0.99570137
58MP0001765_abnormal_ion_homeostasis0.99027462
59MP0006035_abnormal_mitochondrial_morpho0.98479668
60MP0006292_abnormal_olfactory_placode0.96543322
61MP0009745_abnormal_behavioral_response0.96052752
62MP0008932_abnormal_embryonic_tissue0.93457063
63MP0001440_abnormal_grooming_behavior0.91150759
64MP0004957_abnormal_blastocyst_morpholog0.85711675
65MP0000762_abnormal_tongue_morphology0.85671892
66MP0001853_heart_inflammation0.85453381
67MP0003011_delayed_dark_adaptation0.82459651
68MP0005174_abnormal_tail_pigmentation0.81495551
69MP0002184_abnormal_innervation0.77337701
70MP0005389_reproductive_system_phenotype0.76819845
71MP0010771_integument_phenotype0.75891304
72MP0000569_abnormal_digit_pigmentation0.72824017
73MP0001905_abnormal_dopamine_level0.72220742
74MP0003936_abnormal_reproductive_system0.69103811
75MP0005076_abnormal_cell_differentiation0.67636070
76MP0003453_abnormal_keratinocyte_physiol0.66763735
77MP0008995_early_reproductive_senescence0.66525712
78MP0004036_abnormal_muscle_relaxation0.66050811
79MP0002234_abnormal_pharynx_morphology0.65786185
80MP0000383_abnormal_hair_follicle0.65183691
81MP0001216_abnormal_epidermal_layer0.63989461
82MP0002138_abnormal_hepatobiliary_system0.62531304
83MP0000015_abnormal_ear_pigmentation0.62523365
84MP0003786_premature_aging0.61780472
85MP0003950_abnormal_plasma_membrane0.61509094
86MP0005266_abnormal_metabolism0.60739061
87MP0008007_abnormal_cellular_replicative0.60648012
88MP0009764_decreased_sensitivity_to0.60268618
89MP0008004_abnormal_stomach_pH0.60121187
90MP0003699_abnormal_female_reproductive0.60005040
91MP0010678_abnormal_skin_adnexa0.58834543
92MP0001243_abnormal_dermal_layer0.58655994
93MP0000371_diluted_coat_color0.57730511
94MP0005310_abnormal_salivary_gland0.57358572
95MP0002233_abnormal_nose_morphology0.55431164
96MP0003718_maternal_effect0.55383014
97MP0001501_abnormal_sleep_pattern0.55256437
98MP0002876_abnormal_thyroid_physiology0.54907970
99MP0009765_abnormal_xenobiotic_induced0.54574279
100MP0008873_increased_physiological_sensi0.54307543
101MP0003880_abnormal_central_pattern0.53796494
102MP0005397_hematopoietic_system_phenotyp0.53226619
103MP0001545_abnormal_hematopoietic_system0.53226619
104MP0002928_abnormal_bile_duct0.50406052
105MP0000358_abnormal_cell_content/0.50161610
106MP0005636_abnormal_mineral_homeostasis0.49945486
107MP0003111_abnormal_nucleus_morphology0.48349788
108MP0001293_anophthalmia0.48053638
109MP0001119_abnormal_female_reproductive0.46776891
110MP0004084_abnormal_cardiac_muscle0.43846253
111MP0003329_amyloid_beta_deposits0.42080720
112MP0003115_abnormal_respiratory_system0.41441130
113MP0004133_heterotaxia0.41160037
114MP0001730_embryonic_growth_arrest0.40913105
115MP0010307_abnormal_tumor_latency0.39605359
116MP0001324_abnormal_eye_pigmentation0.38915912
117MP0005377_hearing/vestibular/ear_phenot0.37715524
118MP0003878_abnormal_ear_physiology0.37715524
119MP0009278_abnormal_bone_marrow0.37235814
120MP0004134_abnormal_chest_morphology0.35694587
121MP0005253_abnormal_eye_physiology0.35673446
122MP0004019_abnormal_vitamin_homeostasis0.35647529
123MP0006036_abnormal_mitochondrial_physio0.34999515
124MP0009697_abnormal_copulation0.34721636
125MP0003787_abnormal_imprinting0.33988655
126MP0003633_abnormal_nervous_system0.33676067
127MP0002269_muscular_atrophy0.32131210
128MP0004808_abnormal_hematopoietic_stem0.31560793
129MP0005551_abnormal_eye_electrophysiolog0.31132384
130MP0001764_abnormal_homeostasis0.29735515
131MP0005391_vision/eye_phenotype0.28985735
132MP0000427_abnormal_hair_cycle0.28686038
133MP0000313_abnormal_cell_death0.27895330
134MP0005666_abnormal_adipose_tissue0.27703223
135MP0003861_abnormal_nervous_system0.26885323
136MP0002132_abnormal_respiratory_system0.25861162
137MP0003631_nervous_system_phenotype0.25826703
138MP0008875_abnormal_xenobiotic_pharmacok0.25670620
139MP0002736_abnormal_nociception_after0.25503825
140MP0002837_dystrophic_cardiac_calcinosis0.25102850
141MP0004811_abnormal_neuron_physiology0.24031000
142MP0002152_abnormal_brain_morphology0.23638932
143MP0009115_abnormal_fat_cell0.21987683
144MP0002139_abnormal_hepatobiliary_system0.21533614
145MP0000432_abnormal_head_morphology0.21208555
146MP0002084_abnormal_developmental_patter0.20943201
147MP0002971_abnormal_brown_adipose0.20789832
148MP0002169_no_abnormal_phenotype0.18814668
149MP0002873_normal_phenotype0.18573671
150MP0003077_abnormal_cell_cycle0.18451875
151MP0006138_congestive_heart_failure0.17267910
152MP0000604_amyloidosis0.16571839
153MP0001672_abnormal_embryogenesis/_devel0.16214589
154MP0005380_embryogenesis_phenotype0.16214589
155MP0002572_abnormal_emotion/affect_behav0.15994889
156MP0002102_abnormal_ear_morphology0.15592691
157MP0002092_abnormal_eye_morphology0.15174040
158MP0000534_abnormal_ureter_morphology0.15048860
159MP0003879_abnormal_hair_cell0.15031180
160MP0004145_abnormal_muscle_electrophysio0.14847949
161MP0000462_abnormal_digestive_system0.14501532
162MP0009250_abnormal_appendicular_skeleto0.14204139
163MP0002229_neurodegeneration0.14130991
164MP0001697_abnormal_embryo_size0.14076176
165MP0001919_abnormal_reproductive_system0.14069772
166MP0000001_mammalian_phenotype0.13981439
167MP0003984_embryonic_growth_retardation0.13909736
168MP0002405_respiratory_system_inflammati0.12756790
169MP0003943_abnormal_hepatobiliary_system0.12514467

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.75824485
2Abnormal respiratory motile cilium morphology (HP:0005938)8.50164190
3Abnormal respiratory epithelium morphology (HP:0012253)8.50164190
4Abnormal ciliary motility (HP:0012262)8.02888601
5Rhinitis (HP:0012384)8.02522192
6Chronic bronchitis (HP:0004469)7.36853535
7Nasal polyposis (HP:0100582)6.55628863
8Infertility (HP:0000789)6.38103452
9Absent rod-and cone-mediated responses on ERG (HP:0007688)5.66660570
10Abnormality of the nasal mucosa (HP:0000433)5.37712546
11Renal Fanconi syndrome (HP:0001994)5.21143237
12Bronchitis (HP:0012387)4.77279157
13Bronchiectasis (HP:0002110)4.68371571
14Hypoplastic left heart (HP:0004383)4.37447929
15Nephronophthisis (HP:0000090)4.30323615
16Male infertility (HP:0003251)4.26140545
17Hydroureter (HP:0000072)4.16345122
18Overriding aorta (HP:0002623)4.08554845
19Congenital malformation of the right heart (HP:0011723)4.01838035
20Double outlet right ventricle (HP:0001719)4.01838035
21Single umbilical artery (HP:0001195)4.00278983
22Abnormality of the fetal cardiovascular system (HP:0010948)4.00278983
23Abnormal umbilical cord blood vessels (HP:0011403)4.00278983
24Increased hepatocellular lipid droplets (HP:0006565)3.83447708
25Elfin facies (HP:0004428)3.74275716
26Abnormality of the pulmonary veins (HP:0011718)3.73526497
27Abnormal spermatogenesis (HP:0008669)3.64800256
28Recurrent sinusitis (HP:0011108)3.53828744
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.49875420
30Testicular atrophy (HP:0000029)3.48764877
31Hyperacusis (HP:0010780)3.47461824
32Recurrent otitis media (HP:0000403)3.45699944
33Abnormal rod and cone electroretinograms (HP:0008323)3.45655885
34Pili torti (HP:0003777)3.39664916
35Hypoplastic heart (HP:0001961)3.39304572
36Hyperthyroidism (HP:0000836)3.35458331
37Insomnia (HP:0100785)3.34666853
38Abnormality of renal resorption (HP:0011038)3.32501899
39Abnormality of the renal medulla (HP:0100957)3.23488968
40Increased intramyocellular lipid droplets (HP:0012240)3.16720793
41Intestinal atresia (HP:0011100)3.05110191
42Recurrent bronchitis (HP:0002837)3.04229571
43Renovascular hypertension (HP:0100817)3.01430566
44Lipid accumulation in hepatocytes (HP:0006561)3.00991556
45Molar tooth sign on MRI (HP:0002419)2.99059339
46Abnormality of midbrain morphology (HP:0002418)2.99059339
47Flat cornea (HP:0007720)2.87768863
48Increased nuchal translucency (HP:0010880)2.87610355
4911 pairs of ribs (HP:0000878)2.82616639
50Mitochondrial inheritance (HP:0001427)2.81689794
51Hypophosphatemic rickets (HP:0004912)2.73500011
52Medial flaring of the eyebrow (HP:0010747)2.72596235
53Abnormality of the umbilical cord (HP:0010881)2.70970659
54Azoospermia (HP:0000027)2.68349738
55Oligodactyly (hands) (HP:0001180)2.68258710
56Tubulointerstitial nephritis (HP:0001970)2.64381612
57Progressive external ophthalmoplegia (HP:0000590)2.62963009
58Abnormality of the costochondral junction (HP:0000919)2.62089191
59Tubular atrophy (HP:0000092)2.61582602
60Renal duplication (HP:0000075)2.59485604
61Posterior embryotoxon (HP:0000627)2.56057756
62Progressive muscle weakness (HP:0003323)2.54673875
63Selective tooth agenesis (HP:0001592)2.51264842
64Tubulointerstitial abnormality (HP:0001969)2.50954556
65Increased CSF lactate (HP:0002490)2.47874769
66Abnormality of the lower motor neuron (HP:0002366)2.46041865
67Increased muscle lipid content (HP:0009058)2.44046995
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40103791
69Abnormality of the line of Schwalbe (HP:0008048)2.35239007
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35040219
71Acute necrotizing encephalopathy (HP:0006965)2.34245267
72Increased serum lactate (HP:0002151)2.34013047
73Annular pancreas (HP:0001734)2.31866016
74Squamous cell carcinoma (HP:0002860)2.31186033
75Deep palmar crease (HP:0006191)2.31098023
76Ragged-red muscle fibers (HP:0003200)2.29741397
77Abnormal hair laboratory examination (HP:0003328)2.29328975
78Chromsome breakage (HP:0040012)2.28730805
79Gonadotropin excess (HP:0000837)2.23572728
80Glycosuria (HP:0003076)2.23069968
81Abnormality of urine glucose concentration (HP:0011016)2.23069968
82Tubulointerstitial fibrosis (HP:0005576)2.21818779
83Impulsivity (HP:0100710)2.21665279
84Fibular hypoplasia (HP:0003038)2.21363366
85Unilateral renal agenesis (HP:0000122)2.21014653
86Hypertensive crisis (HP:0100735)2.20258139
87Periauricular skin pits (HP:0100277)2.18301794
88Preauricular pit (HP:0004467)2.18301794
89Microglossia (HP:0000171)2.17822480
90Microvesicular hepatic steatosis (HP:0001414)2.17721921
91Postaxial foot polydactyly (HP:0001830)2.16728377
92Abnormal mitochondria in muscle tissue (HP:0008316)2.16556958
93Exertional dyspnea (HP:0002875)2.14330913
94Patellar dislocation (HP:0002999)2.11190999
95Congenital hepatic fibrosis (HP:0002612)2.10205630
96Pancreatic fibrosis (HP:0100732)2.09345519
97Dysphonia (HP:0001618)2.07650844
98Reticulocytopenia (HP:0001896)2.07317371
99Hypercalcemia (HP:0003072)2.06427809
100Follicular hyperkeratosis (HP:0007502)2.05205914
101Macrocytic anemia (HP:0001972)2.04216359
102Transposition of the great arteries (HP:0001669)2.04202035
103Abnormal connection of the cardiac segments (HP:0011545)2.04202035
104Abnormal ventriculo-arterial connection (HP:0011563)2.04202035
105Abnormal lung lobation (HP:0002101)2.02059677
106Absent frontal sinuses (HP:0002688)2.01769671
107Brittle hair (HP:0002299)2.01678552
108Short middle phalanx of the 5th finger (HP:0004220)2.01489677
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.3995062
110Dynein arm defect of respiratory motile cilia (HP:0012255)12.1710007
111Absent/shortened dynein arms (HP:0200106)12.1710007
112Amyotrophic lateral sclerosis (HP:0007354)1.98905896
113Cerebral edema (HP:0002181)1.98372171
114Respiratory difficulties (HP:0002880)1.97408386
115Abnormality of the parathyroid morphology (HP:0011766)1.95648070
116Microretrognathia (HP:0000308)1.94692870
117Severe visual impairment (HP:0001141)1.94661010
118Hepatocellular necrosis (HP:0001404)1.94382224
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94163630
120Abnormality of alanine metabolism (HP:0010916)1.94163630
121Hyperalaninemia (HP:0003348)1.94163630
122Generalized aminoaciduria (HP:0002909)1.93925480
123Duodenal stenosis (HP:0100867)1.93337607
124Small intestinal stenosis (HP:0012848)1.93337607
125Abnormal drinking behavior (HP:0030082)1.92709942
126Polydipsia (HP:0001959)1.92709942
127Facial cleft (HP:0002006)1.91317054
128J-shaped sella turcica (HP:0002680)1.91103667
129Obsessive-compulsive behavior (HP:0000722)1.89841234
130Short ribs (HP:0000773)1.88874913
131Median cleft lip (HP:0000161)1.88654022
132Hyperphosphaturia (HP:0003109)1.88635528
133Redundant skin (HP:0001582)1.87927610
134Exercise intolerance (HP:0003546)1.86161134
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83812884
136Thoracic kyphosis (HP:0002942)1.79685496
137Tongue fasciculations (HP:0001308)1.79624934
138Renal dysplasia (HP:0000110)1.78315457
139Atelectasis (HP:0100750)1.78061602
140Stage 5 chronic kidney disease (HP:0003774)1.77213258
141Degeneration of the lateral corticospinal tracts (HP:0002314)1.76955346
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76955346
143Abnormality of the renal cortex (HP:0011035)1.74161430
144Oculomotor apraxia (HP:0000657)1.73081170
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.73049426
146Abnormal biliary tract physiology (HP:0012439)1.71470562
147Bile duct proliferation (HP:0001408)1.71470562
148Chronic sinusitis (HP:0011109)1.70462954
149Decreased central vision (HP:0007663)1.70067965
150Postaxial hand polydactyly (HP:0001162)1.65452080
151Cystic liver disease (HP:0006706)1.61344373
152Abnormal gallbladder physiology (HP:0012438)1.60709431
153Cholecystitis (HP:0001082)1.60709431
154Muscle fibrillation (HP:0010546)1.60600743
155Abnormality of renal excretion (HP:0011036)1.60263445
156Abnormality of saccadic eye movements (HP:0000570)1.58781306
157Impaired proprioception (HP:0010831)1.58446785
158Deformed sella turcica (HP:0002681)1.57646038
159Abnormality of the dental root (HP:0006486)1.56077199
160Taurodontia (HP:0000679)1.56077199
161Abnormality of permanent molar morphology (HP:0011071)1.56077199
162Dyschromatopsia (HP:0007641)1.54313362
163Abnormality of dentin (HP:0010299)1.52155523
164Spastic tetraparesis (HP:0001285)1.52020405
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51921381
166Absent epiphyses (HP:0010577)1.51921381
167Congenital primary aphakia (HP:0007707)1.48406434
168Gait imbalance (HP:0002141)1.48362520
169Abnormality of ocular smooth pursuit (HP:0000617)1.47469476
170Abnormality of molar (HP:0011077)1.47369420
171Abnormality of molar morphology (HP:0011070)1.47369420
172Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.44275864
173Abnormality of the dental pulp (HP:0006479)1.42473032
174Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.41511071
175Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.40409376
176Short thorax (HP:0010306)1.40226291
177Aplasia/Hypoplasia of the fibula (HP:0006492)1.38003705
178True hermaphroditism (HP:0010459)1.37477854
179Supernumerary spleens (HP:0009799)1.34322389
180Abnormal urine output (HP:0012590)1.32401885
181Aplasia/Hypoplasia of the lens (HP:0008063)1.31915290
182Heterotopia (HP:0002282)1.31780100
183Nephropathy (HP:0000112)1.31330382
184Bell-shaped thorax (HP:0001591)1.30343813
185Upper motor neuron abnormality (HP:0002127)1.29012959
186Chronic hepatic failure (HP:0100626)1.28460912
187Genital tract atresia (HP:0001827)1.26866884
188Occipital encephalocele (HP:0002085)1.25352159
189Nephrogenic diabetes insipidus (HP:0009806)1.23907389
190Pachygyria (HP:0001302)1.23279872
191Spontaneous abortion (HP:0005268)1.22893243
192Degeneration of anterior horn cells (HP:0002398)1.22826745
193Abnormality of the anterior horn cell (HP:0006802)1.22826745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.52585225
2PDK48.52585225
3NME27.51710335
4ZAK5.87019878
5PDK25.50937838
6TESK15.05884877
7LIMK15.04400748
8PRKD34.02633532
9ICK3.39164220
10STK162.92312231
11WNK42.90688293
12MAP3K92.89045517
13STK392.88398860
14PTK2B2.80408003
15MAP3K132.56791749
16MAP3K122.02641139
17PNCK1.95737445
18PBK1.92307889
19STK381.77083588
20IRAK31.73736648
21MAP3K61.73225029
22NEK21.72788922
23MST1R1.71756764
24VRK21.70526391
25ABL21.57091785
26MET1.44693974
27SMG11.41595451
28MAP3K111.41134719
29ARAF1.26968705
30BCKDK1.22032515
31MAP4K21.19998217
32EIF2AK11.16854051
33PDK11.14261249
34STK241.12712093
35WEE11.11665616
36CDC42BPA1.08752102
37CCNB11.06876599
38DYRK1B1.05959521
39WNK11.04830542
40MOS1.04469681
41CASK1.04193726
42LRRK21.03247475
43EPHA21.02297061
44STK38L1.01478862
45TLK10.98854114
46BRSK20.97745893
47TAOK30.94918649
48TYRO30.93937812
49MAPK150.93087651
50TTK0.91471284
51GRK70.91173003
52STK30.84499757
53LMTK20.82360777
54DYRK30.81250879
55BMX0.76039857
56PASK0.73463953
57CDC70.70908743
58CHEK20.69472233
59MAP2K70.68584929
60DMPK0.68494317
61PTK20.67983274
62PINK10.64718049
63PDPK10.63287189
64MKNK20.60763090
65MINK10.58805804
66PIM20.55681531
67MAP2K40.53547142
68CHEK10.52690440
69DAPK10.50563235
70VRK10.49109827
71IRAK10.48844166
72DYRK1A0.48831482
73IKBKB0.48765328
74RPS6KA50.48244753
75PIK3CA0.47939390
76PHKG10.47889548
77PHKG20.47889548
78ATR0.47377188
79LATS10.46240400
80LATS20.45911812
81BRSK10.45455331
82PLK40.45403491
83EEF2K0.45150283
84RPS6KA40.42673594
85MAP3K40.42546577
86RIPK40.39658759
87SCYL20.38668820
88AKT20.37555991
89CSNK1E0.37215586
90PRKCI0.36603644
91PRKCG0.36532829
92MAP2K60.36257209
93PLK10.35929364
94ATM0.35843199
95TESK20.34889766
96ZAP700.34080911
97TGFBR10.34076214
98PAK10.33169978
99CAMK2D0.33123861
100ROCK20.32059902
101MAPKAPK50.31446415
102MUSK0.31145257
103CDK70.29807629
104NTRK20.29366350
105TYK20.29305455
106ROCK10.27395652
107CAMK2G0.27199130
108MAP3K140.27101490
109MAP3K10.27005598
110NUAK10.24931408
111BCR0.24867110
112CAMK2B0.24351192
113AURKB0.23744456
114CAMKK10.21828210
115CAMK1G0.21706346
116NEK60.21414434
117STK100.19686525
118RPS6KB10.19413561
119PRKAA10.19122165
120MTOR0.18035743
121PRKG20.16564325
122PRKCQ0.15600683
123BMPR1B0.15566598
124BUB10.15474390
125WNK30.15211032
126BRAF0.14777250
127ACVR1B0.13827221
128PDGFRB0.13546012
129PRKCZ0.13231593
130IRAK20.13036536
131CSNK2A10.12047482
132PAK20.11847250
133CDK150.11692194
134AURKA0.10104765
135MARK30.09431601
136CDK10.09310684
137CSNK2A20.09267447
138CDK180.08940804
139CDK11A0.08366966
140STK110.08243614
141CDK30.07946850
142CDK20.07160565
143MARK20.07100131
144MAPK80.07068339
145MAP3K100.06522323
146GSK3B0.06509299
147OXSR10.06369921
148PRKG10.05489530
149CDK120.05335548
150CDK140.04549648
151PRKDC0.04388548
152RPS6KA10.04247080
153PRKACG0.03579450
154CAMK2A0.02679036
155TAOK10.01229525
156CSF1R0.00944449
157PRKCA0.00413351
158CSNK1D-0.0208146
159PRKACB-0.0191951
160CDK4-0.0159475
161MAP3K5-0.0098789
162MAPK10-0.0069491
163PRKCB-0.0064708
164PRKCD-0.0048034

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.92505094
2Vitamin B6 metabolism_Homo sapiens_hsa007504.49634617
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.14196080
4DNA replication_Homo sapiens_hsa030304.02410831
5Pyruvate metabolism_Homo sapiens_hsa006203.79570318
6Fatty acid biosynthesis_Homo sapiens_hsa000613.61472732
7Oxidative phosphorylation_Homo sapiens_hsa001903.45941964
8Pentose phosphate pathway_Homo sapiens_hsa000303.40636589
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.29656442
10Basal transcription factors_Homo sapiens_hsa030223.08144935
11Propanoate metabolism_Homo sapiens_hsa006403.01339518
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.85897132
13RNA polymerase_Homo sapiens_hsa030202.82524789
14Linoleic acid metabolism_Homo sapiens_hsa005912.81137910
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.80535367
16Mismatch repair_Homo sapiens_hsa034302.79232387
17Proteasome_Homo sapiens_hsa030502.79214190
18Parkinsons disease_Homo sapiens_hsa050122.78625533
19Glucagon signaling pathway_Homo sapiens_hsa049222.70531387
20Nucleotide excision repair_Homo sapiens_hsa034202.30909626
21Spliceosome_Homo sapiens_hsa030402.17568845
22Fanconi anemia pathway_Homo sapiens_hsa034602.16303103
23Base excision repair_Homo sapiens_hsa034102.04505685
24beta-Alanine metabolism_Homo sapiens_hsa004102.00899173
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98759311
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.98623260
27Oocyte meiosis_Homo sapiens_hsa041141.91530343
28One carbon pool by folate_Homo sapiens_hsa006701.89967110
29Glycerolipid metabolism_Homo sapiens_hsa005611.86078026
30Selenocompound metabolism_Homo sapiens_hsa004501.85863841
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82663182
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80364964
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79164243
34Dorso-ventral axis formation_Homo sapiens_hsa043201.78937849
35Huntingtons disease_Homo sapiens_hsa050161.76547456
36Alzheimers disease_Homo sapiens_hsa050101.70794892
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68235895
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.66277617
39Carbon metabolism_Homo sapiens_hsa012001.61761612
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.59370284
41PPAR signaling pathway_Homo sapiens_hsa033201.56221026
42Renin-angiotensin system_Homo sapiens_hsa046141.53493451
43Amphetamine addiction_Homo sapiens_hsa050311.51484673
44Fructose and mannose metabolism_Homo sapiens_hsa000511.46676845
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.45332235
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.41783655
47Phototransduction_Homo sapiens_hsa047441.40516232
48Fat digestion and absorption_Homo sapiens_hsa049751.40494533
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38556003
50Biosynthesis of amino acids_Homo sapiens_hsa012301.37061641
51Fatty acid elongation_Homo sapiens_hsa000621.30976120
52Ether lipid metabolism_Homo sapiens_hsa005651.28549987
53Cardiac muscle contraction_Homo sapiens_hsa042601.26019873
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21291421
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20511806
56RNA transport_Homo sapiens_hsa030131.17952000
57Vibrio cholerae infection_Homo sapiens_hsa051101.17321163
58Mineral absorption_Homo sapiens_hsa049781.16521043
59Protein export_Homo sapiens_hsa030601.16176748
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.13677162
61Renin secretion_Homo sapiens_hsa049241.13475633
62mRNA surveillance pathway_Homo sapiens_hsa030151.12434599
63Purine metabolism_Homo sapiens_hsa002301.09627966
64Fatty acid degradation_Homo sapiens_hsa000711.08736083
65Fatty acid metabolism_Homo sapiens_hsa012121.07837191
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05142145
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89677939
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88923429
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85843575
70Antigen processing and presentation_Homo sapiens_hsa046120.82774977
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80885129
72p53 signaling pathway_Homo sapiens_hsa041150.80587956
73Glutathione metabolism_Homo sapiens_hsa004800.79711535
74Arachidonic acid metabolism_Homo sapiens_hsa005900.76130855
75Long-term potentiation_Homo sapiens_hsa047200.74599858
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70214648
77Homologous recombination_Homo sapiens_hsa034400.69838195
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69001628
79Chemical carcinogenesis_Homo sapiens_hsa052040.68114406
80Rheumatoid arthritis_Homo sapiens_hsa053230.65196664
81Lysine degradation_Homo sapiens_hsa003100.64632107
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63350331
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63253335
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62289635
85ABC transporters_Homo sapiens_hsa020100.58890541
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58564089
87Estrogen signaling pathway_Homo sapiens_hsa049150.58276970
88Phenylalanine metabolism_Homo sapiens_hsa003600.57977573
89Peroxisome_Homo sapiens_hsa041460.57572325
90Asthma_Homo sapiens_hsa053100.57248629
91Systemic lupus erythematosus_Homo sapiens_hsa053220.57190078
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.56997367
93Tryptophan metabolism_Homo sapiens_hsa003800.56605801
94Insulin secretion_Homo sapiens_hsa049110.55996729
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54570210
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52436954
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51621541
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51567432
99Thyroid hormone synthesis_Homo sapiens_hsa049180.50777983
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.50433338
101Calcium signaling pathway_Homo sapiens_hsa040200.49285665
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48910348
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48730912
104Collecting duct acid secretion_Homo sapiens_hsa049660.48185253
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48038275
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47520477
107AMPK signaling pathway_Homo sapiens_hsa041520.47454215
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45808523
109RNA degradation_Homo sapiens_hsa030180.45675130
110Endocytosis_Homo sapiens_hsa041440.44810951
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44807544
112Hedgehog signaling pathway_Homo sapiens_hsa043400.44442653
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.41200652
114Metabolic pathways_Homo sapiens_hsa011000.41003787
115Bile secretion_Homo sapiens_hsa049760.39646794
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39183372
117Pancreatic secretion_Homo sapiens_hsa049720.36719288
118Epstein-Barr virus infection_Homo sapiens_hsa051690.36322832
119Sulfur metabolism_Homo sapiens_hsa009200.35888839
120Cell cycle_Homo sapiens_hsa041100.35746942
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33375160
122Legionellosis_Homo sapiens_hsa051340.33372683
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.30246725
124Taste transduction_Homo sapiens_hsa047420.30086768
125Pyrimidine metabolism_Homo sapiens_hsa002400.30081781
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.30080604
127Protein digestion and absorption_Homo sapiens_hsa049740.30051654
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29999739
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28345372
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26760365
131Synaptic vesicle cycle_Homo sapiens_hsa047210.26055056
132Inositol phosphate metabolism_Homo sapiens_hsa005620.25301013
133VEGF signaling pathway_Homo sapiens_hsa043700.25230520
134Regulation of autophagy_Homo sapiens_hsa041400.24788147
135Herpes simplex infection_Homo sapiens_hsa051680.23412035
136Salivary secretion_Homo sapiens_hsa049700.23023533
137N-Glycan biosynthesis_Homo sapiens_hsa005100.22825324
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22198980
139Viral carcinogenesis_Homo sapiens_hsa052030.20930677
140Allograft rejection_Homo sapiens_hsa053300.20884827
141Sphingolipid metabolism_Homo sapiens_hsa006000.19901171
142Salmonella infection_Homo sapiens_hsa051320.19324716
143Cocaine addiction_Homo sapiens_hsa050300.16693856
144Arginine and proline metabolism_Homo sapiens_hsa003300.14815629
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14465915
146Retinol metabolism_Homo sapiens_hsa008300.14429123
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14092494
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13067499
149Gastric acid secretion_Homo sapiens_hsa049710.12376945
150Olfactory transduction_Homo sapiens_hsa047400.12349592
151Small cell lung cancer_Homo sapiens_hsa052220.11591354
152Influenza A_Homo sapiens_hsa051640.10925359
153Apoptosis_Homo sapiens_hsa042100.09436759
154Viral myocarditis_Homo sapiens_hsa054160.07749965
155Butanoate metabolism_Homo sapiens_hsa006500.05831671
156Alcoholism_Homo sapiens_hsa050340.03313289
157Autoimmune thyroid disease_Homo sapiens_hsa053200.02812446
158HTLV-I infection_Homo sapiens_hsa051660.00260802

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