SMCO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.79026638
2neuron fate determination (GO:0048664)7.25849697
3ensheathment of neurons (GO:0007272)7.17191173
4axon ensheathment (GO:0008366)7.17191173
5myelination (GO:0042552)7.07090880
6long-chain fatty acid biosynthetic process (GO:0042759)6.23855284
7hepatocyte differentiation (GO:0070365)6.02658151
8DNA double-strand break processing (GO:0000729)6.00063510
9myelin maintenance (GO:0043217)5.80451874
10keratan sulfate catabolic process (GO:0042340)5.65709066
11regulation of DNA endoreduplication (GO:0032875)5.21909788
12peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.02453641
13negative regulation of neurotransmitter secretion (GO:0046929)4.91355851
14cholesterol biosynthetic process (GO:0006695)4.83798809
15cornea development in camera-type eye (GO:0061303)4.82645370
16negative regulation of neurotransmitter transport (GO:0051589)4.67073568
17establishment of mitochondrion localization (GO:0051654)4.64482447
18sequestering of actin monomers (GO:0042989)4.53386229
19oligodendrocyte differentiation (GO:0048709)4.52880135
20glycerophospholipid catabolic process (GO:0046475)4.52711157
21negative regulation of protein localization to cell surface (GO:2000009)4.45657562
22creatine metabolic process (GO:0006600)4.41451110
23anterior/posterior axis specification, embryo (GO:0008595)4.38661008
24fucose catabolic process (GO:0019317)4.37365560
25L-fucose metabolic process (GO:0042354)4.37365560
26L-fucose catabolic process (GO:0042355)4.37365560
27asymmetric protein localization (GO:0008105)4.33179271
28apical protein localization (GO:0045176)4.31965576
29L-amino acid import (GO:0043092)4.26203737
30craniofacial suture morphogenesis (GO:0097094)4.23646764
31sterol biosynthetic process (GO:0016126)4.21220458
32presynaptic membrane organization (GO:0097090)4.20851581
33positive regulation of oligodendrocyte differentiation (GO:0048714)4.20688969
34cranial suture morphogenesis (GO:0060363)4.20561917
35amyloid precursor protein metabolic process (GO:0042982)4.18620818
36regulation of collateral sprouting (GO:0048670)4.14834256
37photoreceptor cell differentiation (GO:0046530)4.12964065
38eye photoreceptor cell differentiation (GO:0001754)4.12964065
39astrocyte development (GO:0014002)4.08101708
40prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.05636240
41camera-type eye morphogenesis (GO:0048593)4.03611846
42embryonic digestive tract morphogenesis (GO:0048557)4.01638589
43positive regulation of neuroblast proliferation (GO:0002052)3.99724017
44long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.96134359
45mitochondrial DNA replication (GO:0006264)3.95816985
46positive regulation of DNA-dependent DNA replication (GO:2000105)3.93055482
47artery development (GO:0060840)3.91935243
48presynaptic membrane assembly (GO:0097105)3.88864561
49centriole replication (GO:0007099)3.86359062
50substantia nigra development (GO:0021762)3.77906908
51peptidyl-tyrosine autophosphorylation (GO:0038083)3.75270153
52regulation of centriole replication (GO:0046599)3.71568802
53long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.69463483
54isoprenoid biosynthetic process (GO:0008299)3.67169880
55hematopoietic stem cell proliferation (GO:0071425)3.64954078
56response to methylmercury (GO:0051597)3.64655849
57midbrain development (GO:0030901)3.60135568
58tongue development (GO:0043586)3.56981657
59myelination in peripheral nervous system (GO:0022011)3.56829458
60peripheral nervous system axon ensheathment (GO:0032292)3.56829458
61response to redox state (GO:0051775)3.54423666
62otic vesicle formation (GO:0030916)3.54113109
63import into cell (GO:0098657)3.52647827
64mesenchymal cell proliferation (GO:0010463)3.52199182
65cell migration involved in heart development (GO:0060973)3.47331049
66protein palmitoylation (GO:0018345)3.44323902
67fatty-acyl-CoA biosynthetic process (GO:0046949)3.43978459
68myoblast fusion (GO:0007520)3.42812015
69neuronal action potential propagation (GO:0019227)3.42416004
70DNA replication checkpoint (GO:0000076)3.42068447
71positive regulation of gastrulation (GO:2000543)3.42022527
72adhesion of symbiont to host cell (GO:0044650)3.41434749
73virion attachment to host cell (GO:0019062)3.41434749
74planar cell polarity pathway involved in neural tube closure (GO:0090179)3.40134639
75GPI anchor biosynthetic process (GO:0006506)3.37552277
76specification of organ identity (GO:0010092)3.32872610
77fatty-acyl-CoA metabolic process (GO:0035337)3.31380146
78spinal cord association neuron differentiation (GO:0021527)3.29715346
79microtubule depolymerization (GO:0007019)3.29298176
80positive regulation of developmental pigmentation (GO:0048087)3.29187579
81neuron cell-cell adhesion (GO:0007158)3.26447907
82magnesium ion transport (GO:0015693)3.23094575
83GPI anchor metabolic process (GO:0006505)3.22394601
84cerebral cortex radially oriented cell migration (GO:0021799)3.20038499
85positive regulation of action potential (GO:0045760)3.19522905
86establishment of planar polarity (GO:0001736)3.19061842
87establishment of tissue polarity (GO:0007164)3.19061842
88response to lipoprotein particle (GO:0055094)3.18833134
89axon development (GO:0061564)3.18720690
90adult walking behavior (GO:0007628)3.17800720
91amyloid precursor protein catabolic process (GO:0042987)3.17632426
92regulation of lipoprotein metabolic process (GO:0050746)3.16522269
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16376871
94atrial cardiac muscle cell action potential (GO:0086014)3.16227808
95membrane tubulation (GO:0097320)3.15333964
96regulation of pigment cell differentiation (GO:0050932)3.14846338
97G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.13297732
98negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.13149686
99positive regulation of embryonic development (GO:0040019)3.12962603
100regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.11245058
101response to pheromone (GO:0019236)3.09610698
102very long-chain fatty acid metabolic process (GO:0000038)3.08273003
103digestive tract morphogenesis (GO:0048546)3.05607402
104negative regulation of axonogenesis (GO:0050771)3.04908197
105trophoblast giant cell differentiation (GO:0060707)3.04677356
106neurotransmitter uptake (GO:0001504)3.02124187
107amino acid import (GO:0043090)3.00789008
108transmission of nerve impulse (GO:0019226)2.98992076
109peptidyl-cysteine modification (GO:0018198)2.98030930
110positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.97726411
111preassembly of GPI anchor in ER membrane (GO:0016254)2.96796221
112glycosylceramide metabolic process (GO:0006677)2.94874843
113sperm motility (GO:0030317)2.93481630
114nerve growth factor signaling pathway (GO:0038180)2.93176922
115negative regulation of JUN kinase activity (GO:0043508)2.92444440
116retrograde transport, vesicle recycling within Golgi (GO:0000301)2.91168651
117limb bud formation (GO:0060174)2.89231494
118syncytium formation by plasma membrane fusion (GO:0000768)2.88696106
119neuron remodeling (GO:0016322)2.85672093
120phosphatidylethanolamine biosynthetic process (GO:0006646)2.85295214
121peripheral nervous system development (GO:0007422)2.84909427
122protein targeting to Golgi (GO:0000042)2.84856324
123leukocyte migration involved in inflammatory response (GO:0002523)2.83749131
124positive regulation of cellular amine metabolic process (GO:0033240)2.79520878
125radial glial cell differentiation (GO:0060019)2.79267403
126acyl-CoA biosynthetic process (GO:0071616)2.78294390
127thioester biosynthetic process (GO:0035384)2.78294390
128cellular response to epinephrine stimulus (GO:0071872)2.77062573
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.76445839
130protein neddylation (GO:0045116)2.76091427
131regulation of neuroblast proliferation (GO:1902692)2.76009125
132positive regulation of glial cell differentiation (GO:0045687)2.75762265
133centriole assembly (GO:0098534)2.74438513
134establishment of protein localization to Golgi (GO:0072600)2.74399904
135epithelial cilium movement (GO:0003351)2.71969219
136Leydig cell differentiation (GO:0033327)2.71399517
137glial cell development (GO:0021782)2.70005094
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69793689
139regulation of meiosis I (GO:0060631)2.68818232
140generation of neurons (GO:0048699)2.67681296
141syncytium formation (GO:0006949)2.67588600
142microtubule polymerization or depolymerization (GO:0031109)2.67539132
143erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65929246
144L-phenylalanine catabolic process (GO:0006559)2.65929246
145phosphatidylethanolamine metabolic process (GO:0046337)2.64975967
146translesion synthesis (GO:0019985)2.63413265
147cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.62564655
148organ growth (GO:0035265)2.62020197
149cysteine metabolic process (GO:0006534)2.61948889
150glomerular basement membrane development (GO:0032836)2.60349929
151left/right axis specification (GO:0070986)2.59332330
152response to lead ion (GO:0010288)2.58111674
153mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.56434260
154enteric nervous system development (GO:0048484)2.56068492
155lateral sprouting from an epithelium (GO:0060601)2.55287399
156cranial nerve development (GO:0021545)2.54691393
157limb development (GO:0060173)2.54331091
158appendage development (GO:0048736)2.54331091
159telomere maintenance via semi-conservative replication (GO:0032201)2.54306239
160collagen fibril organization (GO:0030199)2.53496827
161positive regulation of gliogenesis (GO:0014015)2.53443458
162mannosylation (GO:0097502)2.53292552
163negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51501116
164membrane assembly (GO:0071709)2.51081834
165regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.50905016
166negative regulation of execution phase of apoptosis (GO:1900118)2.50491009
167neural nucleus development (GO:0048857)2.50384726
168neuronal ion channel clustering (GO:0045161)2.50217504
169negative regulation of hormone biosynthetic process (GO:0032353)2.48945540
170glutathione biosynthetic process (GO:0006750)2.48888605
171nucleotide transmembrane transport (GO:1901679)2.48077726
172negative regulation of axon extension (GO:0030517)2.47896181
173detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.46380792
174detection of temperature stimulus involved in sensory perception (GO:0050961)2.46380792
175histone H3-K9 demethylation (GO:0033169)2.43790500
176outflow tract septum morphogenesis (GO:0003148)2.43767093
177chromosome condensation (GO:0030261)2.41991530
178regulation of smoothened signaling pathway (GO:0008589)2.41426378
179lung lobe morphogenesis (GO:0060463)2.41193372
180mitochondrial DNA metabolic process (GO:0032042)2.40727409
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40104762
182neuronal stem cell maintenance (GO:0097150)2.39975665
183translational termination (GO:0006415)2.37548938
184cilium assembly (GO:0042384)2.37135399
185regulation of hippo signaling (GO:0035330)2.36927628
186genitalia morphogenesis (GO:0035112)2.36848275
187embryonic axis specification (GO:0000578)2.36054975
188prostate gland growth (GO:0060736)2.35542868
189negative regulation of fibrinolysis (GO:0051918)2.35204787
190eye morphogenesis (GO:0048592)2.35125595
191negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.34532334
192axon ensheathment in central nervous system (GO:0032291)11.8695589
193central nervous system myelination (GO:0022010)11.8695589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.18966287
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.83723382
3GBX2_23144817_ChIP-Seq_PC3_Human3.37261357
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.18566044
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.89326781
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.79707292
7TAF15_26573619_Chip-Seq_HEK293_Human2.52495064
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33175974
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32403622
10EZH2_22144423_ChIP-Seq_EOC_Human2.20058854
11E2F7_22180533_ChIP-Seq_HELA_Human2.13287395
12OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.10707466
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06197040
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00601698
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99086929
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98702222
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.96262414
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93495217
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93127829
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93127829
21TP53_18474530_ChIP-ChIP_U2OS_Human1.91009248
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90960305
23ER_23166858_ChIP-Seq_MCF-7_Human1.86550651
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85407534
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81271200
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.80258100
27AR_21572438_ChIP-Seq_LNCaP_Human1.76177175
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75694943
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.73219084
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73007880
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69715102
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66222005
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66222005
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66037372
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65564797
36EWS_26573619_Chip-Seq_HEK293_Human1.65490677
37VDR_22108803_ChIP-Seq_LS180_Human1.62877028
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62105176
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60894861
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59588357
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58866271
42DROSHA_22980978_ChIP-Seq_HELA_Human1.55403122
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54891233
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.53802493
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51227352
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.50961271
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49473345
48STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.49334675
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.47795897
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46994491
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46712080
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.46504545
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46396931
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45845434
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.43594895
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41783699
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41421566
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.39797105
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39296991
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37666177
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37612050
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36074899
63TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36006231
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35587521
65TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35367125
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.33374179
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.33192966
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31685838
69CJUN_26792858_Chip-Seq_BT549_Human1.31442550
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30094456
71FUS_26573619_Chip-Seq_HEK293_Human1.29554508
72P300_19829295_ChIP-Seq_ESCs_Human1.29257915
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28468534
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27765490
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27714011
76NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26968318
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26968318
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25960760
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.25583338
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23309958
81AR_25329375_ChIP-Seq_VCAP_Human1.22064305
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.19710219
83FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18387025
84RARB_27405468_Chip-Seq_BRAIN_Mouse1.16114760
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.16095363
86TBL1_22424771_ChIP-Seq_293T_Human1.14455515
87LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13901456
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12990114
89BCAT_22108803_ChIP-Seq_LS180_Human1.12901108
90CBP_20019798_ChIP-Seq_JUKART_Human1.11568402
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11568402
92SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10590701
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09292119
94EOMES_21245162_ChIP-Seq_HESCs_Human1.08441947
95REST_21632747_ChIP-Seq_MESCs_Mouse1.07349502
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07305731
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.07304659
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07125827
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.06094952
100HTT_18923047_ChIP-ChIP_STHdh_Human1.05820144
101STAT3_23295773_ChIP-Seq_U87_Human1.05448556
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05340903
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04892970
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04036533
105SOX2_16153702_ChIP-ChIP_HESCs_Human1.04024637
106IGF1R_20145208_ChIP-Seq_DFB_Human1.03984469
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.03909364
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03362941
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03207656
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.02191263
111SOX9_26525672_Chip-Seq_HEART_Mouse1.02162373
112AHR_22903824_ChIP-Seq_MCF-7_Human1.01869951
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.01416391
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.01349620
115RUNX2_22187159_ChIP-Seq_PCA_Human1.00741345
116SMAD4_21799915_ChIP-Seq_A2780_Human1.00597375
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.99686599
118REST_18959480_ChIP-ChIP_MESCs_Mouse0.99627303
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98984094
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95888914
121SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95488977
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95323628
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95320396
124TCF4_23295773_ChIP-Seq_U87_Human0.94648703
125P300_18555785_Chip-Seq_ESCs_Mouse0.94014180
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93978222
127RNF2_27304074_Chip-Seq_NSC_Mouse0.93742425
128NANOG_19829295_ChIP-Seq_ESCs_Human0.93302293
129SOX2_19829295_ChIP-Seq_ESCs_Human0.93302293
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93193581
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91550489
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90859669
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90337368
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89194100
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88858784
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88119942
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87970650
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87676361
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85401553
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.83891181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology6.58234046
2MP0000920_abnormal_myelination5.72813378
3MP0005275_abnormal_skin_tensile4.11505723
4MP0006292_abnormal_olfactory_placode3.75446378
5MP0003880_abnormal_central_pattern3.62540674
6MP0003950_abnormal_plasma_membrane3.56931022
7MP0005503_abnormal_tendon_morphology3.40742890
8MP0003690_abnormal_glial_cell3.40313566
9MP0004270_analgesia3.17228952
10MP0005248_abnormal_Harderian_gland2.90880414
11MP0001529_abnormal_vocalization2.87696487
12MP0004885_abnormal_endolymph2.81942112
13MP0003136_yellow_coat_color2.80181089
14MP0002234_abnormal_pharynx_morphology2.62904124
15MP0003329_amyloid_beta_deposits2.61375621
16MP0005171_absent_coat_pigmentation2.59034706
17MP0002272_abnormal_nervous_system2.57203929
18MP0003634_abnormal_glial_cell2.54362074
19MP0001905_abnormal_dopamine_level2.48312338
20MP0004742_abnormal_vestibular_system2.40964661
21MP0001486_abnormal_startle_reflex2.34718725
22MP0002064_seizures2.26755001
23MP0004142_abnormal_muscle_tone2.23168480
24MP0002249_abnormal_larynx_morphology2.18083279
25MP0000778_abnormal_nervous_system2.10193473
26MP0001485_abnormal_pinna_reflex2.04287679
27MP0002229_neurodegeneration1.94580368
28MP0003632_abnormal_nervous_system1.90944768
29MP0005423_abnormal_somatic_nervous1.87417928
30MP0005409_darkened_coat_color1.84372358
31MP0004859_abnormal_synaptic_plasticity1.79227384
32MP0004043_abnormal_pH_regulation1.77314884
33MP0005410_abnormal_fertilization1.76727020
34MP0009046_muscle_twitch1.76269604
35MP0004381_abnormal_hair_follicle1.73069529
36MP0004134_abnormal_chest_morphology1.72584278
37MP0003011_delayed_dark_adaptation1.70222935
38MP0002734_abnormal_mechanical_nocicepti1.69616203
39MP0003635_abnormal_synaptic_transmissio1.68881684
40MP0008789_abnormal_olfactory_epithelium1.67494808
41MP0009745_abnormal_behavioral_response1.64741544
42MP0000462_abnormal_digestive_system1.56537832
43MP0010678_abnormal_skin_adnexa1.56394280
44MP0008260_abnormal_autophagy1.55203882
45MP0000569_abnormal_digit_pigmentation1.52965539
46MP0003806_abnormal_nucleotide_metabolis1.51817002
47MP0003631_nervous_system_phenotype1.50614024
48MP0001661_extended_life_span1.47586082
49MP0000631_abnormal_neuroendocrine_gland1.46845911
50MP0008057_abnormal_DNA_replication1.40902003
51MP0005197_abnormal_uvea_morphology1.39827008
52MP0005551_abnormal_eye_electrophysiolog1.39554841
53MP0000604_amyloidosis1.39096520
54MP0000747_muscle_weakness1.36909365
55MP0008569_lethality_at_weaning1.36725976
56MP0005391_vision/eye_phenotype1.36107343
57MP0005377_hearing/vestibular/ear_phenot1.36049563
58MP0003878_abnormal_ear_physiology1.36049563
59MP0000383_abnormal_hair_follicle1.35833292
60MP0000955_abnormal_spinal_cord1.35067323
61MP0002882_abnormal_neuron_morphology1.34965047
62MP0002092_abnormal_eye_morphology1.34747944
63MP0002108_abnormal_muscle_morphology1.34409308
64MP0000049_abnormal_middle_ear1.31784144
65MP0002572_abnormal_emotion/affect_behav1.30506328
66MP0005623_abnormal_meninges_morphology1.30167994
67MP0002282_abnormal_trachea_morphology1.30145294
68MP0003633_abnormal_nervous_system1.28523004
69MP0005499_abnormal_olfactory_system1.27579820
70MP0005394_taste/olfaction_phenotype1.27579820
71MP0002067_abnormal_sensory_capabilities1.26858752
72MP0004147_increased_porphyrin_level1.25216753
73MP0002066_abnormal_motor_capabilities/c1.24681884
74MP0001440_abnormal_grooming_behavior1.23096511
75MP0005451_abnormal_body_composition1.22474812
76MP0003195_calcinosis1.22375677
77MP0001970_abnormal_pain_threshold1.21988524
78MP0009053_abnormal_anal_canal1.21227993
79MP0001963_abnormal_hearing_physiology1.19998014
80MP0001299_abnormal_eye_distance/1.19324271
81MP0001346_abnormal_lacrimal_gland1.17263224
82MP0008438_abnormal_cutaneous_collagen1.16726306
83MP0002063_abnormal_learning/memory/cond1.16369282
84MP0004145_abnormal_muscle_electrophysio1.16354844
85MP0009697_abnormal_copulation1.15616337
86MP0002697_abnormal_eye_size1.12255414
87MP0010386_abnormal_urinary_bladder1.11648358
88MP0002752_abnormal_somatic_nervous1.10325101
89MP0000566_synostosis1.09914449
90MP0001293_anophthalmia1.09237251
91MP0004133_heterotaxia1.08817428
92MP0000372_irregular_coat_pigmentation1.08148281
93MP0009250_abnormal_appendicular_skeleto1.05531981
94MP0002233_abnormal_nose_morphology1.05120245
95MP0001324_abnormal_eye_pigmentation1.04921679
96MP0003755_abnormal_palate_morphology1.04072053
97MP0004924_abnormal_behavior1.02831703
98MP0005386_behavior/neurological_phenoty1.02831703
99MP0003385_abnormal_body_wall1.02560888
100MP0005058_abnormal_lysosome_morphology1.01261160
101MP0002733_abnormal_thermal_nociception1.00026614
102MP0003938_abnormal_ear_development0.96565911
103MP0005195_abnormal_posterior_eye0.96045685
104MP0003890_abnormal_embryonic-extraembry0.94529587
105MP0001851_eye_inflammation0.94364790
106MP0001348_abnormal_lacrimal_gland0.94291722
107MP0001968_abnormal_touch/_nociception0.92844309
108MP0000647_abnormal_sebaceous_gland0.91118918
109MP0003943_abnormal_hepatobiliary_system0.89496578
110MP0000762_abnormal_tongue_morphology0.88359843
111MP0002075_abnormal_coat/hair_pigmentati0.88208043
112MP0002735_abnormal_chemical_nociception0.87941694
113MP0004185_abnormal_adipocyte_glucose0.86876326
114MP0000537_abnormal_urethra_morphology0.85752063
115MP0000428_abnormal_craniofacial_morphol0.84848999
116MP0002295_abnormal_pulmonary_circulatio0.84322571
117MP0001177_atelectasis0.84143952
118MP0004272_abnormal_basement_membrane0.83676163
119MP0002822_catalepsy0.83441013
120MP0001666_abnormal_nutrient_absorption0.83206254
121MP0001286_abnormal_eye_development0.80027496
122MP0005408_hypopigmentation0.79486491
123MP0000749_muscle_degeneration0.78847265
124MP0002152_abnormal_brain_morphology0.78553934
125MP0003283_abnormal_digestive_organ0.78194526
126MP0003937_abnormal_limbs/digits/tail_de0.77684956
127MP0004036_abnormal_muscle_relaxation0.77444131
128MP0006082_CNS_inflammation0.76978199
129MP0002932_abnormal_joint_morphology0.75931384
130MP0008961_abnormal_basal_metabolism0.75871429
131MP0001186_pigmentation_phenotype0.74768980
132MP0005253_abnormal_eye_physiology0.74759550
133MP0002090_abnormal_vision0.73803194
134MP0001501_abnormal_sleep_pattern0.73531311
135MP0000026_abnormal_inner_ear0.72341552
136MP0000579_abnormal_nail_morphology0.70036454
137MP0000003_abnormal_adipose_tissue0.68884442
138MP0005646_abnormal_pituitary_gland0.68757944
139MP0003942_abnormal_urinary_system0.67907859
140MP0002184_abnormal_innervation0.66594154
141MP0000534_abnormal_ureter_morphology0.66414653
142MP0002736_abnormal_nociception_after0.65809840
143MP0002109_abnormal_limb_morphology0.65374811
144MP0005193_abnormal_anterior_eye0.64505156
145MP0003861_abnormal_nervous_system0.64365706
146MP0002116_abnormal_craniofacial_bone0.63199097
147MP0002557_abnormal_social/conspecific_i0.61304332
148MP0003698_abnormal_male_reproductive0.61023531
149MP0004085_abnormal_heartbeat0.60934129
150MP0005508_abnormal_skeleton_morphology0.60519869
151MP0000432_abnormal_head_morphology0.60275643
152MP0001502_abnormal_circadian_rhythm0.60234229
153MP0003935_abnormal_craniofacial_develop0.60154283
154MP0002938_white_spotting0.58827970
155MP0004811_abnormal_neuron_physiology0.58022831
156MP0000751_myopathy0.57928822
157MP0006276_abnormal_autonomic_nervous0.57748353
158MP0001340_abnormal_eyelid_morphology0.57288323
159MP0002638_abnormal_pupillary_reflex0.57117348
160MP0003137_abnormal_impulse_conducting0.56552974
161MP0005379_endocrine/exocrine_gland_phen0.56452132
162MP0003122_maternal_imprinting0.56351716
163MP0005187_abnormal_penis_morphology0.56113675
164MP0003656_abnormal_erythrocyte_physiolo0.55881215
165MP0002876_abnormal_thyroid_physiology0.55736996
166MP0001929_abnormal_gametogenesis0.55560464
167MP0001243_abnormal_dermal_layer0.53572704
168MP0003868_abnormal_feces_composition0.51514121
169MP0000371_diluted_coat_color0.51496690
170MP0009703_decreased_birth_body0.51407590
171MP0005083_abnormal_biliary_tract0.50808903

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.91457263
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.91457263
3Neurofibrillary tangles (HP:0002185)5.53351723
4Abnormality of the corticospinal tract (HP:0002492)5.27166015
5Parakeratosis (HP:0001036)5.05694761
6Peripheral hypomyelination (HP:0007182)4.78648046
7Termporal pattern (HP:0011008)4.53208119
8Insidious onset (HP:0003587)4.53208119
9Sensory axonal neuropathy (HP:0003390)4.44348241
10Ectopic kidney (HP:0000086)4.17391306
11Onion bulb formation (HP:0003383)4.16310522
12Cerebral inclusion bodies (HP:0100314)3.92449849
13Abnormal auditory evoked potentials (HP:0006958)3.88535031
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.82247784
15Abnormality of the labia minora (HP:0012880)3.75437637
16Cerebral hypomyelination (HP:0006808)3.65797153
17Segmental peripheral demyelination/remyelination (HP:0003481)3.65601675
18Spastic gait (HP:0002064)3.51572808
19Abnormality of the phalanges of the hallux (HP:0010057)3.51301549
20Abnormality of the pons (HP:0007361)3.31645888
21Alacrima (HP:0000522)3.26255360
22Short 4th metacarpal (HP:0010044)3.24402581
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.24402581
24Supranuclear gaze palsy (HP:0000605)3.20820707
25Microglossia (HP:0000171)3.19717266
26Leukodystrophy (HP:0002415)3.12747999
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.09540962
28Slender build (HP:0001533)3.05620857
29Septo-optic dysplasia (HP:0100842)3.03255585
30Intention tremor (HP:0002080)3.01577463
31Anteriorly placed anus (HP:0001545)2.92605159
32Dysmetria (HP:0001310)2.91248667
33Abnormality of glycolysis (HP:0004366)2.90965875
34Increased serum pyruvate (HP:0003542)2.90965875
35Abnormal number of erythroid precursors (HP:0012131)2.88226631
36Cutaneous finger syndactyly (HP:0010554)2.86454119
37Myokymia (HP:0002411)2.78334173
38Scanning speech (HP:0002168)2.75210973
39Abnormality of the aortic arch (HP:0012303)2.73546727
40Congenital ichthyosiform erythroderma (HP:0007431)2.73461758
41Gastrointestinal atresia (HP:0002589)2.71822605
42Sleep apnea (HP:0010535)2.71573830
43Partial duplication of the phalanx of hand (HP:0009999)2.68197297
44Hypoplasia of the pons (HP:0012110)2.65601267
45Ankle clonus (HP:0011448)2.64945447
46Abnormality of cells of the erythroid lineage (HP:0012130)2.63508829
47Decreased lacrimation (HP:0000633)2.63412863
48Hypoplastic pelvis (HP:0008839)2.61668041
49Abnormality of the parietal bone (HP:0002696)2.61503350
50Split foot (HP:0001839)2.60968232
51Duplication of thumb phalanx (HP:0009942)2.60503529
52Autoamputation (HP:0001218)2.60005273
53Preaxial foot polydactyly (HP:0001841)2.58713366
54Foot dorsiflexor weakness (HP:0009027)2.57447703
55Stridor (HP:0010307)2.56365587
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.55491343
57Akinesia (HP:0002304)2.55250620
58Premature skin wrinkling (HP:0100678)2.55091955
59Cerebral hemorrhage (HP:0001342)2.54117907
60Retinal dysplasia (HP:0007973)2.50431720
61Slow saccadic eye movements (HP:0000514)2.50290959
62Supernumerary spleens (HP:0009799)2.49248756
63Thickened helices (HP:0000391)2.47937930
64Natal tooth (HP:0000695)2.44390225
65Duplicated collecting system (HP:0000081)2.43852486
66Absent septum pellucidum (HP:0001331)2.41523416
67Increased circulating renin level (HP:0000848)2.38396028
68Muscle fiber splitting (HP:0003555)2.37896243
69Abnormality of cochlea (HP:0000375)2.37723277
70Action tremor (HP:0002345)2.37715236
71Hypomagnesemia (HP:0002917)2.31643402
72CNS hypomyelination (HP:0003429)2.31449744
73Abnormality of the foot musculature (HP:0001436)2.30761616
74Pheochromocytoma (HP:0002666)2.30614584
75Abnormality of the metopic suture (HP:0005556)2.29543385
76Hypoplastic labia majora (HP:0000059)2.29259062
77Congenital glaucoma (HP:0001087)2.28985124
78Aplasia/Hypoplasia of the tongue (HP:0010295)2.28512679
79Decreased motor nerve conduction velocity (HP:0003431)2.28303378
80Lower limb muscle weakness (HP:0007340)2.27256383
81Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24856408
82Oligodactyly (HP:0012165)2.24819578
83Thin ribs (HP:0000883)2.24102870
84Exertional dyspnea (HP:0002875)2.24057389
85Spastic paraparesis (HP:0002313)2.23796550
86Spinal cord compression (HP:0002176)2.23580133
87Clumsiness (HP:0002312)2.23361330
88Aqueductal stenosis (HP:0002410)2.23082351
89Morphological abnormality of the inner ear (HP:0011390)2.22666580
90Cutaneous syndactyly (HP:0012725)2.21558415
91Obstructive sleep apnea (HP:0002870)2.21126952
92Hypophosphatemic rickets (HP:0004912)2.20245705
93Genital tract atresia (HP:0001827)2.14936406
94Soft skin (HP:0000977)2.14536661
95Spastic tetraparesis (HP:0001285)2.14465632
96Abnormality of the 4th metacarpal (HP:0010012)2.14211161
97Thyroid-stimulating hormone excess (HP:0002925)2.14075109
98Megalencephaly (HP:0001355)2.12953101
99Abnormality of the septum pellucidum (HP:0007375)2.12136081
100Pancreatic fibrosis (HP:0100732)2.10887468
101Hepatosplenomegaly (HP:0001433)2.10310845
102Coronal craniosynostosis (HP:0004440)2.10093125
103Abnormality of the labia majora (HP:0012881)2.09519421
104Broad metatarsal (HP:0001783)2.08895147
105Abnormality of the antihelix (HP:0009738)2.08114915
106Abnormality of the proximal phalanges of the hand (HP:0009834)2.06316901
107Peripheral demyelination (HP:0011096)2.05240040
108Ulnar claw (HP:0001178)2.05021416
109Renal Fanconi syndrome (HP:0001994)2.02593226
110Neuroendocrine neoplasm (HP:0100634)2.02585453
111Convex nasal ridge (HP:0000444)2.00802252
112Flat cornea (HP:0007720)2.00712270
113Infantile muscular hypotonia (HP:0008947)2.00355817
114Abnormality of the 2nd finger (HP:0004100)1.99671080
115Bell-shaped thorax (HP:0001591)1.99655617
116Esophageal atresia (HP:0002032)1.99171196
117Aplasia involving bones of the extremities (HP:0009825)1.99140599
118Aplasia involving bones of the upper limbs (HP:0009823)1.99140599
119Aplasia of the phalanges of the hand (HP:0009802)1.99140599
120White forelock (HP:0002211)1.98914648
121Facial hemangioma (HP:0000329)1.98615665
122Premature rupture of membranes (HP:0001788)1.98197840
123Turricephaly (HP:0000262)1.98125736
124Metabolic alkalosis (HP:0200114)1.97901357
125Severe Myopia (HP:0011003)1.97547330
126Abnormality of the renal collecting system (HP:0004742)1.97437728
127Abnormality of incisor morphology (HP:0011063)1.97297996
128Growth hormone deficiency (HP:0000824)1.96607434
129Vaginal atresia (HP:0000148)1.95623243
130Midline defect of the nose (HP:0004122)1.94371824
131Patchy hypopigmentation of hair (HP:0011365)1.94336155
132Gowers sign (HP:0003391)1.94281877
133Hammertoe (HP:0001765)1.93062440
134Bowel incontinence (HP:0002607)1.92465720
135Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.91855934
136Axonal loss (HP:0003447)1.90300292
137Urinary urgency (HP:0000012)1.89020946
138Shallow orbits (HP:0000586)1.87382419
139Urinary incontinence (HP:0000020)1.86887536
140Poor speech (HP:0002465)1.86781471
141Hyporeflexia of lower limbs (HP:0002600)1.86460039
142Acute necrotizing encephalopathy (HP:0006965)1.86443812
143Partial agenesis of the corpus callosum (HP:0001338)1.86395588
144Morphological abnormality of the pyramidal tract (HP:0002062)1.85656174
145Severe visual impairment (HP:0001141)1.85138121
146Recurrent corneal erosions (HP:0000495)1.83807078
147Abnormality of the nasolacrimal system (HP:0000614)1.82816446
148Trigonocephaly (HP:0000243)1.82494683
149Clonus (HP:0002169)1.81797565
150Hypokalemic alkalosis (HP:0001949)1.81150655
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81027233
152Visceral angiomatosis (HP:0100761)1.80799775
153Distal sensory impairment (HP:0002936)1.80198427
154Overriding aorta (HP:0002623)1.79879819
155Ulnar bowing (HP:0003031)1.79099367
156Abnormal large intestine physiology (HP:0012700)1.78956271
157Atonic seizures (HP:0010819)1.78507742
158Stenosis of the external auditory canal (HP:0000402)1.78466002
159Progressive inability to walk (HP:0002505)1.78417153
160Methylmalonic acidemia (HP:0002912)1.77768477
161Pancreatic cysts (HP:0001737)1.77643634
162Synostosis involving the elbow (HP:0003938)1.77527168
163Humeroradial synostosis (HP:0003041)1.77527168
1643-Methylglutaconic aciduria (HP:0003535)1.76280875
165Hypoplasia of the iris (HP:0007676)1.76057418
166Hemangiomatosis (HP:0007461)1.73223424
167Abnormality of the middle phalanges of the toes (HP:0010183)1.72061992
168Focal motor seizures (HP:0011153)1.71412184
169Partial duplication of thumb phalanx (HP:0009944)1.70974031
170Keratoconus (HP:0000563)1.70672573
171Increased corneal curvature (HP:0100692)1.70672573
172Mixed hearing impairment (HP:0000410)1.69629570
173Optic nerve hypoplasia (HP:0000609)1.69132824
174True hermaphroditism (HP:0010459)1.68494829
175Labial hypoplasia (HP:0000066)1.68047123
176Anal atresia (HP:0002023)1.68033031
177Rhinitis (HP:0012384)1.65684274
178Corneal dystrophy (HP:0001131)1.63925261
179Drooling (HP:0002307)1.63345964
180Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.62643716
181Fused cervical vertebrae (HP:0002949)1.61942874
182Abnormality of the diencephalon (HP:0010662)1.61327886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.56177368
2OXSR14.57243140
3PLK43.48992088
4ERBB33.29067773
5EPHB13.16267794
6PKN12.82888552
7WNK42.64340845
8PBK2.61192838
9BCR2.53528992
10MAPKAPK52.48074543
11CDK192.36375618
12FGFR22.34801221
13LIMK12.26934386
14STK38L2.26357040
15TRIM282.14907271
16MET2.13720773
17TNIK2.08158272
18WNK12.06154152
19INSRR2.04114632
20WEE11.94922005
21EIF2AK11.86366006
22UHMK11.84731548
23NLK1.77401209
24MST41.76370433
25CSNK1G31.74977540
26LATS11.72359062
27NEK61.72093964
28CSNK1A1L1.64456518
29PNCK1.62596586
30CAMK2B1.62380169
31NTRK11.60916899
32PLK21.59754400
33DAPK21.55955517
34PASK1.55051304
35ICK1.50759079
36EPHA31.50047721
37PRPF4B1.49872292
38ROCK21.49669988
39WNK31.44750935
40FGR1.43027909
41TGFBR11.42150426
42BRSK21.41089320
43TESK21.36850804
44CAMK2D1.35089262
45GRK51.35045578
46CASK1.32840836
47CSNK1G11.31509877
48SGK2231.30914104
49SGK4941.30914104
50CSNK1G21.25069977
51MAP3K41.24269688
52PAK61.23273715
53FRK1.22187479
54CLK11.22151245
55TLK11.19837946
56DYRK21.18752244
57TGFBR21.18034810
58AKT31.13385113
59MAP2K71.12814221
60SRPK11.10589629
61MAP3K121.08609939
62MUSK1.05971867
63SGK21.05169550
64CAMK2G1.03229446
65IRAK21.02871201
66MARK11.01988586
67CDK31.01643329
68EPHA40.98470984
69FGFR10.95980205
70MAP2K40.95502953
71GRK10.95473037
72PRKCQ0.93507816
73ACVR1B0.91061925
74STK380.90168695
75EPHB20.87521299
76CDK140.85420674
77SGK30.85390180
78CAMK2A0.85065486
79BMPR1B0.84934571
80PAK30.84569650
81CDK50.83097696
82ERBB40.82940395
83TRPM70.76528889
84CDK150.75754712
85TYRO30.75581989
86MARK20.75521963
87NEK90.74631448
88BRD40.74465558
89MAPK150.71365242
90MAP3K60.71332237
91PRKD10.71108007
92CDK180.70696698
93PHKG20.70307849
94PHKG10.70307849
95STK30.67282357
96CDK11A0.65878960
97VRK10.65430826
98PRKCE0.63748096
99DMPK0.60506274
100FER0.60448483
101PDPK10.58954933
102ADRBK10.57406386
103NTRK20.56908185
104FYN0.56137720
105MAPK130.55015176
106CAMK10.54778643
107PRKG10.52691638
108SIK10.51226370
109GSK3A0.51198018
110RPS6KA50.50684954
111PRKCH0.48115050
112PDGFRA0.47112206
113CSNK1D0.46728423
114GRK70.46202012
115KSR20.45819650
116BCKDK0.44259112
117PRKACB0.43960599
118PLK10.43209008
119PRKAA20.41527791
120ERBB20.40957581
121AURKB0.40762758
122ATM0.40561699
123ADRBK20.40388463
124CDC70.40150945
125CSNK1A10.38774445
126ARAF0.37640357
127CHEK10.37469335
128MAPK70.37437963
129IRAK10.37155821
130PIK3CA0.36691618
131MST1R0.36678185
132MAP2K20.36651792
133PIK3CG0.35945849
134CAMK1D0.35399666
135PINK10.35244230
136CDK80.34573848
137ATR0.34047513
138PAK10.33342334
139EIF2AK20.32990825
140STK240.32676051
141OBSCN0.32345747
142CDK10.32237082
143ITK0.31664638
144INSR0.31251261
145GSK3B0.31043991
146CDK20.30249736
147STK110.29881188
148PRKACA0.29693068
149RPS6KC10.29471901
150RPS6KL10.29471901
151MTOR0.28974824
152PRKDC0.28429808
153PTK2B0.28290800
154MKNK10.28252173
155SGK10.27575987
156MAP3K20.27273682
157MAP3K130.27105886
158RPS6KA60.26556151
159PDK10.25566409
160ROCK10.25471052
161FES0.25358157
162PDGFRB0.22330868
163STK160.22097361
164DDR20.21985401
165SRC0.21418166
166CAMK1G0.21413243
167CSNK1E0.21397665

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.32084030
2Steroid biosynthesis_Homo sapiens_hsa001004.54276269
3Fatty acid elongation_Homo sapiens_hsa000624.46447949
4Basal cell carcinoma_Homo sapiens_hsa052174.24999605
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.29759063
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.07830951
7Ether lipid metabolism_Homo sapiens_hsa005652.89352342
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.87805622
9Oxidative phosphorylation_Homo sapiens_hsa001902.37097483
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35267780
11Vitamin B6 metabolism_Homo sapiens_hsa007502.28954651
12Ribosome_Homo sapiens_hsa030102.28122969
13Caffeine metabolism_Homo sapiens_hsa002322.22294937
14Sulfur metabolism_Homo sapiens_hsa009202.14748274
15Protein export_Homo sapiens_hsa030602.06307145
16DNA replication_Homo sapiens_hsa030302.01832731
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80870059
18Hippo signaling pathway_Homo sapiens_hsa043901.80445893
19Sphingolipid metabolism_Homo sapiens_hsa006001.74057795
20Protein digestion and absorption_Homo sapiens_hsa049741.73004128
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72044430
22Histidine metabolism_Homo sapiens_hsa003401.72033412
23Fanconi anemia pathway_Homo sapiens_hsa034601.71768891
24Wnt signaling pathway_Homo sapiens_hsa043101.71513664
25Parkinsons disease_Homo sapiens_hsa050121.70198642
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.68230445
27Axon guidance_Homo sapiens_hsa043601.64530915
28Tryptophan metabolism_Homo sapiens_hsa003801.55626961
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53914964
30Alzheimers disease_Homo sapiens_hsa050101.53439101
31Linoleic acid metabolism_Homo sapiens_hsa005911.50259042
32Butanoate metabolism_Homo sapiens_hsa006501.47846713
33Nitrogen metabolism_Homo sapiens_hsa009101.44048211
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42091141
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39857562
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38368412
37Mismatch repair_Homo sapiens_hsa034301.38032907
38Retinol metabolism_Homo sapiens_hsa008301.36219289
39TGF-beta signaling pathway_Homo sapiens_hsa043501.31658785
40Phenylalanine metabolism_Homo sapiens_hsa003601.31175758
41Non-homologous end-joining_Homo sapiens_hsa034501.30688130
42GABAergic synapse_Homo sapiens_hsa047271.29467682
43Complement and coagulation cascades_Homo sapiens_hsa046101.28725816
44Collecting duct acid secretion_Homo sapiens_hsa049661.20533053
45Glutamatergic synapse_Homo sapiens_hsa047241.18475842
46Serotonergic synapse_Homo sapiens_hsa047261.18318576
47Melanogenesis_Homo sapiens_hsa049161.15279560
48Vibrio cholerae infection_Homo sapiens_hsa051101.12368423
49Arginine and proline metabolism_Homo sapiens_hsa003301.11788812
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11656992
51Nucleotide excision repair_Homo sapiens_hsa034201.11158441
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10057275
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02447480
54Long-term depression_Homo sapiens_hsa047301.01124029
55Renal cell carcinoma_Homo sapiens_hsa052111.01071826
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.99734641
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99717613
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97075964
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95670025
60Morphine addiction_Homo sapiens_hsa050320.95025179
61Tight junction_Homo sapiens_hsa045300.94480012
62Fatty acid degradation_Homo sapiens_hsa000710.93931555
63beta-Alanine metabolism_Homo sapiens_hsa004100.93314115
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91885843
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90701073
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.89305709
67Bile secretion_Homo sapiens_hsa049760.86137378
68Cardiac muscle contraction_Homo sapiens_hsa042600.86011053
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83833623
70Circadian rhythm_Homo sapiens_hsa047100.82412606
71Rheumatoid arthritis_Homo sapiens_hsa053230.82095253
72Huntingtons disease_Homo sapiens_hsa050160.80965799
73Propanoate metabolism_Homo sapiens_hsa006400.80180838
74Glutathione metabolism_Homo sapiens_hsa004800.79097331
75Homologous recombination_Homo sapiens_hsa034400.78570848
76Fatty acid metabolism_Homo sapiens_hsa012120.74505617
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72542999
78Arachidonic acid metabolism_Homo sapiens_hsa005900.70605963
79RNA transport_Homo sapiens_hsa030130.70422978
80Cocaine addiction_Homo sapiens_hsa050300.68205565
81Endocytosis_Homo sapiens_hsa041440.68189660
82Small cell lung cancer_Homo sapiens_hsa052220.66960296
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.65910147
84Lysine degradation_Homo sapiens_hsa003100.64013669
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.63862381
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.63531428
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.63521274
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62882986
89Arginine biosynthesis_Homo sapiens_hsa002200.62445214
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.62162225
91Circadian entrainment_Homo sapiens_hsa047130.61964068
92Ras signaling pathway_Homo sapiens_hsa040140.61776012
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.61423995
94RNA polymerase_Homo sapiens_hsa030200.60549900
95Nicotine addiction_Homo sapiens_hsa050330.59672187
96Lysosome_Homo sapiens_hsa041420.59491882
97Phagosome_Homo sapiens_hsa041450.59425763
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58991546
99Olfactory transduction_Homo sapiens_hsa047400.58858480
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58751150
101Synaptic vesicle cycle_Homo sapiens_hsa047210.58556432
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58115206
103Salivary secretion_Homo sapiens_hsa049700.58104438
104Ovarian steroidogenesis_Homo sapiens_hsa049130.57223083
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56800334
106One carbon pool by folate_Homo sapiens_hsa006700.56177752
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54445328
108Gastric acid secretion_Homo sapiens_hsa049710.54392239
109Thyroid cancer_Homo sapiens_hsa052160.52861432
110Cholinergic synapse_Homo sapiens_hsa047250.52693755
111Dopaminergic synapse_Homo sapiens_hsa047280.51736154
112Autoimmune thyroid disease_Homo sapiens_hsa053200.51713737
113N-Glycan biosynthesis_Homo sapiens_hsa005100.51421863
114Proteoglycans in cancer_Homo sapiens_hsa052050.51018128
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49712657
116Alcoholism_Homo sapiens_hsa050340.49552176
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48165971
118Phototransduction_Homo sapiens_hsa047440.48142580
119ECM-receptor interaction_Homo sapiens_hsa045120.46487900
120Selenocompound metabolism_Homo sapiens_hsa004500.46450384
121Adherens junction_Homo sapiens_hsa045200.45593973
122Cell cycle_Homo sapiens_hsa041100.45516993
123Mineral absorption_Homo sapiens_hsa049780.44674655
124ErbB signaling pathway_Homo sapiens_hsa040120.44052755
125Peroxisome_Homo sapiens_hsa041460.43894736
126Metabolic pathways_Homo sapiens_hsa011000.43070408
127Systemic lupus erythematosus_Homo sapiens_hsa053220.42717933
128Pancreatic secretion_Homo sapiens_hsa049720.42317433
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41710776
130Purine metabolism_Homo sapiens_hsa002300.41673169
131cAMP signaling pathway_Homo sapiens_hsa040240.41508256
132Chemical carcinogenesis_Homo sapiens_hsa052040.41331125
133Dorso-ventral axis formation_Homo sapiens_hsa043200.40611262
134Folate biosynthesis_Homo sapiens_hsa007900.39502870
135Malaria_Homo sapiens_hsa051440.39492753
136Tyrosine metabolism_Homo sapiens_hsa003500.39159219
137Vitamin digestion and absorption_Homo sapiens_hsa049770.38318477
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37183253
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35685102
140Gap junction_Homo sapiens_hsa045400.34902867
141Hedgehog signaling pathway_Homo sapiens_hsa043400.34334521
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33499209
143Taste transduction_Homo sapiens_hsa047420.32221351
144Renin secretion_Homo sapiens_hsa049240.31860981
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29359293
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28127873
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26857318
148Glycerolipid metabolism_Homo sapiens_hsa005610.26615272
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25555554
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25222556
151Prion diseases_Homo sapiens_hsa050200.24828195
152Pyruvate metabolism_Homo sapiens_hsa006200.24807842
153Fatty acid biosynthesis_Homo sapiens_hsa000610.22929689

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