SMCO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)4.77805384
2immunoglobulin mediated immune response (GO:0016064)4.32312292
3regulation of female gonad development (GO:2000194)4.17298099
4folic acid-containing compound biosynthetic process (GO:0009396)4.02630102
5protein K6-linked ubiquitination (GO:0085020)3.91854759
6neutrophil activation involved in immune response (GO:0002283)3.66861265
7piRNA metabolic process (GO:0034587)3.64551904
8regulation of histone H3-K27 methylation (GO:0061085)3.58756432
9B cell mediated immunity (GO:0019724)3.56190138
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.53620331
11DNA damage response, signal transduction resulting in transcription (GO:0042772)3.52667735
12mitotic sister chromatid cohesion (GO:0007064)3.51199180
13regulation of chronic inflammatory response (GO:0002676)3.50193272
14regulation of meiosis (GO:0040020)3.48405191
15regulation of sister chromatid cohesion (GO:0007063)3.47527096
16mitotic metaphase plate congression (GO:0007080)3.36150178
17notochord development (GO:0030903)3.33231269
18positive regulation of monocyte chemotaxis (GO:0090026)3.29226630
19positive regulation of chemokine biosynthetic process (GO:0045080)3.27872980
20regulation of cytokine secretion involved in immune response (GO:0002739)3.26738077
21regulation of podosome assembly (GO:0071801)3.26360707
22positive regulation of megakaryocyte differentiation (GO:0045654)3.24813584
23interferon-gamma-mediated signaling pathway (GO:0060333)3.20839107
24response to peptidoglycan (GO:0032494)3.19952833
25female gamete generation (GO:0007292)3.19663750
26meiotic cell cycle (GO:0051321)3.19140724
27meiotic chromosome segregation (GO:0045132)3.18550411
28response to interferon-beta (GO:0035456)3.18049781
29regulation of mononuclear cell migration (GO:0071675)3.15696310
30positive regulation of antigen processing and presentation (GO:0002579)3.15065091
31histone H2A monoubiquitination (GO:0035518)3.11986412
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10361892
33negative regulation of meiosis (GO:0045835)3.09604764
34positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08654840
35DNA damage induced protein phosphorylation (GO:0006975)3.07890599
36negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.06968414
37regulation of antigen processing and presentation (GO:0002577)3.06674754
38viral transcription (GO:0019083)3.02514425
39regulation of vitamin D biosynthetic process (GO:0060556)3.02323324
40regulation of chemokine biosynthetic process (GO:0045073)3.00715623
41T-helper 1 type immune response (GO:0042088)3.00480114
42protein localization to chromosome, centromeric region (GO:0071459)3.00447443
43regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.00243119
44metaphase plate congression (GO:0051310)2.99825691
45macrophage activation involved in immune response (GO:0002281)2.99388538
46cellular response to type I interferon (GO:0071357)2.99157096
47type I interferon signaling pathway (GO:0060337)2.99157096
48granulocyte activation (GO:0036230)2.99103848
49eosinophil chemotaxis (GO:0048245)2.96193138
50DNA deamination (GO:0045006)2.95978463
513-UTR-mediated mRNA stabilization (GO:0070935)2.95201617
52mitotic sister chromatid segregation (GO:0000070)2.94759750
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94610955
54response to type I interferon (GO:0034340)2.93975999
55mitotic nuclear envelope disassembly (GO:0007077)2.93730315
56translational termination (GO:0006415)2.93608432
57regulation of T-helper 1 cell differentiation (GO:0045625)2.93230290
58positive regulation of gamma-delta T cell activation (GO:0046645)2.93219878
59positive regulation of DNA-dependent DNA replication (GO:2000105)2.92856882
60gene silencing by RNA (GO:0031047)2.92473977
61regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91721971
62myoblast migration (GO:0051451)2.86263594
63positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.84554589
64positive regulation of granulocyte differentiation (GO:0030854)2.84524409
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83718655
66attachment of spindle microtubules to kinetochore (GO:0008608)2.83696632
67regulation of interferon-alpha production (GO:0032647)2.83663919
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.83204388
69defense response to protozoan (GO:0042832)2.82528762
70paraxial mesoderm development (GO:0048339)2.82002309
71establishment of chromosome localization (GO:0051303)2.79534502
72regulation of inflammatory response to antigenic stimulus (GO:0002861)2.79069911
73antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.77885148
74regulation of proton transport (GO:0010155)2.77520114
75cytidine metabolic process (GO:0046087)2.76601354
76cytidine catabolic process (GO:0006216)2.76601354
77cytidine deamination (GO:0009972)2.76601354
78cellular response to interferon-gamma (GO:0071346)2.76301053
79regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.75906545
80negative regulation of smooth muscle cell differentiation (GO:0051151)2.75822778
81pteridine-containing compound biosynthetic process (GO:0042559)2.75128106
82neutrophil activation (GO:0042119)2.74970009
83lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73607606
84modulation of growth of symbiont involved in interaction with host (GO:0044144)2.73138230
85regulation of growth of symbiont in host (GO:0044126)2.73138230
86negative regulation of growth of symbiont in host (GO:0044130)2.73138230
87negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.73138230
88regulation of interleukin-12 production (GO:0032655)2.72694535
89regulation of exit from mitosis (GO:0007096)2.72440823
90response to interferon-gamma (GO:0034341)2.72011514
91positive regulation by symbiont of host defense response (GO:0052509)2.69390742
92modulation by symbiont of host defense response (GO:0052031)2.69390742
93modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69390742
94modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69390742
95positive regulation by organism of defense response of other organism involved in symbiotic interact2.69390742
96modulation by symbiont of host immune response (GO:0052553)2.69390742
97positive regulation of interleukin-12 production (GO:0032735)2.67950624
98positive thymic T cell selection (GO:0045059)2.67841366
99cytoplasmic mRNA processing body assembly (GO:0033962)2.67834607
100negative regulation of myeloid cell apoptotic process (GO:0033033)2.66856745
101lymphocyte chemotaxis (GO:0048247)2.66048332
102negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.65517189
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65408983
104nuclear envelope disassembly (GO:0051081)2.64913820
105membrane disassembly (GO:0030397)2.64913820
106sister chromatid cohesion (GO:0007062)2.64763448
107indole-containing compound catabolic process (GO:0042436)2.64521170
108indolalkylamine catabolic process (GO:0046218)2.64521170
109tryptophan catabolic process (GO:0006569)2.64521170
110folic acid metabolic process (GO:0046655)2.64327820
111regulation of vitamin metabolic process (GO:0030656)2.64051119
112one-carbon metabolic process (GO:0006730)2.63737850
113detection of other organism (GO:0098543)2.63448107
114regulation of T cell tolerance induction (GO:0002664)2.63351187
115eosinophil migration (GO:0072677)2.63003284
116myeloid dendritic cell differentiation (GO:0043011)2.61880868
117respiratory burst (GO:0045730)2.61860580
118ribosomal small subunit biogenesis (GO:0042274)2.61572960
119positive regulation of NF-kappaB import into nucleus (GO:0042346)2.61519308
120oligosaccharide catabolic process (GO:0009313)2.60851161
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59196631
122positive regulation of mast cell activation involved in immune response (GO:0033008)2.59099717
123positive regulation of mast cell degranulation (GO:0043306)2.59099717
124myeloid dendritic cell activation (GO:0001773)2.58861448
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.58843198
126ATP synthesis coupled proton transport (GO:0015986)2.58843198
127monoubiquitinated protein deubiquitination (GO:0035520)2.58771436
128translational elongation (GO:0006414)2.58513270
129response to protozoan (GO:0001562)2.58303130
130cellular response to interferon-beta (GO:0035458)2.58249875
131detection of bacterium (GO:0016045)2.58136552
132negative regulation of viral genome replication (GO:0045071)2.57927316
133kinetochore organization (GO:0051383)2.57376098
134regulation of interferon-beta biosynthetic process (GO:0045357)2.57318107
135negative regulation of histone methylation (GO:0031061)2.56610738
136negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.56531038
137negative regulation of DNA-templated transcription, elongation (GO:0032785)2.56531038
138hydrogen peroxide biosynthetic process (GO:0050665)2.55139548
139monocyte chemotaxis (GO:0002548)2.54599945
140protein localization to kinetochore (GO:0034501)2.54321513
141nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.53976174
142regulation of meiosis I (GO:0060631)2.53934913
143myeloid cell activation involved in immune response (GO:0002275)2.53153449
144regulation of meiotic cell cycle (GO:0051445)2.53085247
145male meiosis (GO:0007140)2.51261720
146positive regulation of mast cell activation (GO:0033005)2.51075757
147chromosome condensation (GO:0030261)2.50148212
148positive regulation of prostaglandin secretion (GO:0032308)2.49802360
149regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49466713
150positive regulation of interferon-alpha production (GO:0032727)2.49371995
151glycosphingolipid catabolic process (GO:0046479)2.48957988
152positive regulation of interleukin-1 beta secretion (GO:0050718)2.48676882
153kinetochore assembly (GO:0051382)2.48459443
154sister chromatid segregation (GO:0000819)2.48449867
155positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.48381557
156histone H2A ubiquitination (GO:0033522)2.48182054
157regulation of interleukin-1 beta secretion (GO:0050706)2.47929329
158chromatin assembly or disassembly (GO:0006333)2.47716748
159drug catabolic process (GO:0042737)2.47620092
160chromatin remodeling at centromere (GO:0031055)2.46958312
161kynurenine metabolic process (GO:0070189)2.46389044
162dendritic cell chemotaxis (GO:0002407)2.45924221
163positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.45370721
164pyrimidine ribonucleoside catabolic process (GO:0046133)2.45341696
165negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45239520
166negative regulation of cell killing (GO:0031342)2.45239520
167NIK/NF-kappaB signaling (GO:0038061)2.44588913
168positive regulation of interferon-gamma production (GO:0032729)2.44454538
169nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.43968841
170protein complex localization (GO:0031503)2.43758713
171RNA stabilization (GO:0043489)2.43313013
172mRNA stabilization (GO:0048255)2.43313013
173regulation of hippo signaling (GO:0035330)2.42745400
174maturation of 5.8S rRNA (GO:0000460)2.42644190
175DNA replication-independent nucleosome organization (GO:0034724)2.41911976
176DNA replication-independent nucleosome assembly (GO:0006336)2.41911976
177type B pancreatic cell development (GO:0003323)2.41428173
178endothelial tube morphogenesis (GO:0061154)2.39665806
179morphogenesis of an endothelium (GO:0003159)2.39665806
180protein localization to chromosome (GO:0034502)2.39653210
181DNA replication checkpoint (GO:0000076)2.39433869
182CENP-A containing nucleosome assembly (GO:0034080)2.38096444
183translational initiation (GO:0006413)2.36732101
184positive regulation of keratinocyte differentiation (GO:0045618)2.35084372
185intestinal epithelial cell development (GO:0060576)2.32792977
186regulation of RNA stability (GO:0043487)2.32787086
187SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.32584486
188regulation of double-strand break repair via homologous recombination (GO:0010569)2.30958237
189negative regulation of cell aging (GO:0090344)2.30129209
190citrulline biosynthetic process (GO:0019240)2.29961333
191regulation of RIG-I signaling pathway (GO:0039535)2.29893538
192T cell apoptotic process (GO:0070231)2.29708509
193chromosome segregation (GO:0007059)2.29642390
194negative regulation of interleukin-12 production (GO:0032695)2.28750111
195regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.28697024
196cysteine metabolic process (GO:0006534)2.28330957
197protein targeting to ER (GO:0045047)2.24218435
198regulation of cardioblast differentiation (GO:0051890)2.21490744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85621241
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.41618271
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.41070203
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.84847458
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.18158413
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.24742005
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10303770
8AR_21909140_ChIP-Seq_LNCAP_Human3.08588135
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00394084
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.89591407
11MYC_22102868_ChIP-Seq_BL_Human2.86141440
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71025661
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.68550093
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.65452549
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65359876
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.62249954
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.44462954
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.41659096
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40330971
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37766665
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23727051
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15967681
23RXR_22158963_ChIP-Seq_LIVER_Mouse2.14876892
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14339080
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10122621
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.06943330
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04706668
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02406925
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98081621
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96997169
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95304519
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94730697
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92096144
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.90981895
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88023875
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85879452
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.82639232
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82295437
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79714065
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.79580907
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75428838
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74521565
43MYC_18940864_ChIP-ChIP_HL60_Human1.72138309
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.72067837
45VDR_21846776_ChIP-Seq_THP-1_Human1.68545162
46UTX_26944678_Chip-Seq_JUKART_Human1.67997197
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66741516
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64680159
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62433468
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60127671
51TCF7_22412390_ChIP-Seq_EML_Mouse1.58172176
52VDR_23849224_ChIP-Seq_CD4+_Human1.54522809
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54472409
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.53169752
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.53028900
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52066968
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.51872047
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49309268
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48510738
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47968859
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43422342
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.42987627
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40572881
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39787452
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37119214
66MYB_26560356_Chip-Seq_TH2_Human1.36857457
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36498981
68GATA3_26560356_Chip-Seq_TH2_Human1.31400293
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30610235
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30114848
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29328210
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28547134
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26777899
74STAT1_20625510_ChIP-Seq_HELA_Human1.26376405
75MAF_26560356_Chip-Seq_TH1_Human1.24972579
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24673905
77GATA6_25053715_ChIP-Seq_YYC3_Human1.24431032
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23133467
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22824986
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22745151
81KDM5A_27292631_Chip-Seq_BREAST_Human1.22383970
82MYB_26560356_Chip-Seq_TH1_Human1.22081000
83SCL_19346495_ChIP-Seq_HPC-7_Human1.21359531
84BCL6_27268052_Chip-Seq_Bcells_Human1.19685626
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.19402782
86ATF3_27146783_Chip-Seq_COLON_Human1.19354828
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17813441
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17559450
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17438809
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16610247
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.15775686
92FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.14521273
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13767674
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13203119
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12854442
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12276820
97TFEB_21752829_ChIP-Seq_HELA_Human1.11241587
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10647902
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10529531
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10152868
101SPI1_23127762_ChIP-Seq_K562_Human1.09762711
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09393696
103SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09143842
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08506209
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08154032
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08000027
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04749356
108MAF_26560356_Chip-Seq_TH2_Human1.04378326
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03822988
110ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03444563
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03382161
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01270550
113ELK1_19687146_ChIP-ChIP_HELA_Human1.00903750
114MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00392560
115GATA3_27048872_Chip-Seq_THYMUS_Human1.00151167
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00089228
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99461376
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99139535
119VDR_24787735_ChIP-Seq_THP-1_Human0.98989054
120MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97827900
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97147303
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96489730
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96316935
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95607827
125EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95148209
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94990958
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.94880246
128GATA4_25053715_ChIP-Seq_YYC3_Human0.93702858
129NANOG_20526341_ChIP-Seq_ESCs_Human0.93435239
130VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92748132
131NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92235215
132BCOR_27268052_Chip-Seq_Bcells_Human0.91837220
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91043859
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89718063
135P300_27268052_Chip-Seq_Bcells_Human0.89537651
136FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89371747
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88867146
138RUNX_20019798_ChIP-Seq_JUKART_Human0.88831291
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88457809
140GABP_19822575_ChIP-Seq_HepG2_Human0.88328339
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.87607181
142XRN2_22483619_ChIP-Seq_HELA_Human0.87565895
143RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87134370
144VDR_24763502_ChIP-Seq_THP-1_Human0.86453627
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86418814
146SA1_27219007_Chip-Seq_Bcells_Human0.86196470
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85947990
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.85682748
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85579939
150E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85257012
151CTCF_26484167_Chip-Seq_Bcells_Mouse0.85144317
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84863653
153CTCF_21964334_Chip-Seq_Bcells_Human0.84310519
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.84078759
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83465809
156CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81934916
157TBX20_22080862_ChIP-Seq_HEART_Mouse0.79607616
158TBX20_22328084_ChIP-Seq_HEART_Mouse0.79607616
159FOXP3_21729870_ChIP-Seq_TREG_Human0.79169482
160KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78757451
161TTF2_22483619_ChIP-Seq_HELA_Human0.77587730
162SPI1_23547873_ChIP-Seq_NB4_Human0.77352205
163CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77288560
164RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76610678
165FLI1_27457419_Chip-Seq_LIVER_Mouse0.75731734
166GATA3_26560356_Chip-Seq_TH1_Human0.75620398
167DCP1A_22483619_ChIP-Seq_HELA_Human0.75167553
168PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74705461
169SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73535602
170NANOG_18555785_ChIP-Seq_MESCs_Mouse0.73213871
171E2F1_18555785_ChIP-Seq_MESCs_Mouse0.72711455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.89593331
2MP0009785_altered_susceptibility_to3.65165482
3MP0006082_CNS_inflammation3.45025563
4MP0005451_abnormal_body_composition3.42460060
5MP0002148_abnormal_hypersensitivity_rea3.38310699
6MP0003806_abnormal_nucleotide_metabolis3.32824215
7MP0003646_muscle_fatigue2.96246210
8MP0003718_maternal_effect2.80699396
9MP0003693_abnormal_embryo_hatching2.74516839
10MP0003436_decreased_susceptibility_to2.68578747
11MP0003195_calcinosis2.59525187
12MP0005025_abnormal_response_to2.54055382
13MP0005000_abnormal_immune_tolerance2.50883287
14MP0005387_immune_system_phenotype2.47828308
15MP0001790_abnormal_immune_system2.47828308
16MP0002419_abnormal_innate_immunity2.47797810
17MP0004510_myositis2.26809539
18MP0002254_reproductive_system_inflammat2.26243450
19MP0002452_abnormal_antigen_presenting2.25100631
20MP0002723_abnormal_immune_serum2.23623442
21MP0003763_abnormal_thymus_physiology2.22071804
22MP0005058_abnormal_lysosome_morphology2.21142795
23MP0010368_abnormal_lymphatic_system2.17373592
24MP0004957_abnormal_blastocyst_morpholog2.16798497
25MP0005360_urolithiasis2.12402585
26MP0009840_abnormal_foam_cell2.10441004
27MP0004185_abnormal_adipocyte_glucose2.05523726
28MP0001873_stomach_inflammation1.99447999
29MP0002139_abnormal_hepatobiliary_system1.99408098
30MP0002837_dystrophic_cardiac_calcinosis1.99190550
31MP0003300_gastrointestinal_ulcer1.98287010
32MP0000490_abnormal_crypts_of1.93660615
33MP0000685_abnormal_immune_system1.92505663
34MP0001819_abnormal_immune_cell1.92346371
35MP0003075_altered_response_to1.91261869
36MP0003111_abnormal_nucleus_morphology1.91071014
37MP0002420_abnormal_adaptive_immunity1.90801516
38MP0005365_abnormal_bile_salt1.90582482
39MP0001845_abnormal_inflammatory_respons1.89193417
40MP0009764_decreased_sensitivity_to1.89097898
41MP0003077_abnormal_cell_cycle1.88868878
42MP0008469_abnormal_protein_level1.85873233
43MP0010094_abnormal_chromosome_stability1.78030806
44MP0003705_abnormal_hypodermis_morpholog1.72125755
45MP0002653_abnormal_ependyma_morphology1.68755946
46MP0003303_peritoneal_inflammation1.61435260
47MP0002396_abnormal_hematopoietic_system1.61190395
48MP0000343_altered_response_to1.59615493
49MP0004264_abnormal_extraembryonic_tissu1.58116420
50MP0001533_abnormal_skeleton_physiology1.55545704
51MP0003186_abnormal_redox_activity1.53906686
52MP0005310_abnormal_salivary_gland1.46551800
53MP0005085_abnormal_gallbladder_physiolo1.41764844
54MP0005166_decreased_susceptibility_to1.41190083
55MP0001119_abnormal_female_reproductive1.41033924
56MP0002102_abnormal_ear_morphology1.40728119
57MP0005408_hypopigmentation1.40458921
58MP0003191_abnormal_cellular_cholesterol1.39572089
59MP0000716_abnormal_immune_system1.37687332
60MP0006036_abnormal_mitochondrial_physio1.37343065
61MP0003699_abnormal_female_reproductive1.32396989
62MP0003172_abnormal_lysosome_physiology1.31565435
63MP0005464_abnormal_platelet_physiology1.31314909
64MP0002249_abnormal_larynx_morphology1.28735143
65MP0008875_abnormal_xenobiotic_pharmacok1.27520419
66MP0005395_other_phenotype1.23557851
67MP0010234_abnormal_vibrissa_follicle1.23301674
68MP0001915_intracranial_hemorrhage1.23077325
69MP0008004_abnormal_stomach_pH1.20969344
70MP0003724_increased_susceptibility_to1.18853269
71MP0009333_abnormal_splenocyte_physiolog1.17956435
72MP0001764_abnormal_homeostasis1.17245931
73MP0005319_abnormal_enzyme/_coenzyme1.16841047
74MP0005220_abnormal_exocrine_pancreas1.14412750
75MP0004947_skin_inflammation1.14109878
76MP0002277_abnormal_respiratory_mucosa1.12100143
77MP0000604_amyloidosis1.11728795
78MP0000566_synostosis1.10936238
79MP0001849_ear_inflammation1.10932025
80MP0002429_abnormal_blood_cell1.10052451
81MP0002019_abnormal_tumor_incidence1.09103597
82MP0009763_increased_sensitivity_to1.09037475
83MP0003252_abnormal_bile_duct1.06971342
84MP0006054_spinal_hemorrhage1.05889144
85MP0003448_altered_tumor_morphology1.05872419
86MP0002693_abnormal_pancreas_physiology1.05812058
87MP0008877_abnormal_DNA_methylation1.05804245
88MP0008007_abnormal_cellular_replicative1.05794637
89MP0000350_abnormal_cell_proliferation1.03435473
90MP0005332_abnormal_amino_acid1.03420838
91MP0001730_embryonic_growth_arrest1.02307611
92MP0002132_abnormal_respiratory_system1.00888539
93MP0005380_embryogenesis_phenotype0.99669736
94MP0001672_abnormal_embryogenesis/_devel0.99669736
95MP0001545_abnormal_hematopoietic_system0.98709930
96MP0005397_hematopoietic_system_phenotyp0.98709930
97MP0004019_abnormal_vitamin_homeostasis0.98293912
98MP0002998_abnormal_bone_remodeling0.98186197
99MP0004808_abnormal_hematopoietic_stem0.97821570
100MP0000653_abnormal_sex_gland0.96979415
101MP0001346_abnormal_lacrimal_gland0.95825117
102MP0005671_abnormal_response_to0.95818124
103MP0002085_abnormal_embryonic_tissue0.94094522
104MP0006035_abnormal_mitochondrial_morpho0.92015146
105MP0001697_abnormal_embryo_size0.91487135
106MP0001929_abnormal_gametogenesis0.91408875
107MP0003984_embryonic_growth_retardation0.90671739
108MP0000858_altered_metastatic_potential0.89602521
109MP0002088_abnormal_embryonic_growth/wei0.89265166
110MP0002138_abnormal_hepatobiliary_system0.89088584
111MP0001919_abnormal_reproductive_system0.88954168
112MP0010352_gastrointestinal_tract_polyps0.88561523
113MP0003453_abnormal_keratinocyte_physiol0.87363559
114MP0002210_abnormal_sex_determination0.87298519
115MP0002098_abnormal_vibrissa_morphology0.86624094
116MP0002086_abnormal_extraembryonic_tissu0.85907999
117MP0002405_respiratory_system_inflammati0.85250645
118MP0005165_increased_susceptibility_to0.85181465
119MP0000703_abnormal_thymus_morphology0.85136956
120MP0001800_abnormal_humoral_immune0.84797168
121MP0001501_abnormal_sleep_pattern0.84450911
122MP0002398_abnormal_bone_marrow0.83449140
123MP0002876_abnormal_thyroid_physiology0.83332630
124MP0009765_abnormal_xenobiotic_induced0.83127294
125MP0005647_abnormal_sex_gland0.82975207
126MP0000465_gastrointestinal_hemorrhage0.82908456
127MP0005636_abnormal_mineral_homeostasis0.82208701
128MP0010155_abnormal_intestine_physiology0.81439186
129MP0000477_abnormal_intestine_morphology0.79876198
130MP0005023_abnormal_wound_healing0.79182964
131MP0003937_abnormal_limbs/digits/tail_de0.77186397
132MP0002722_abnormal_immune_system0.77138392
133MP0005666_abnormal_adipose_tissue0.77013929
134MP0005584_abnormal_enzyme/coenzyme_acti0.76653992
135MP0006292_abnormal_olfactory_placode0.76115497
136MP0003866_abnormal_defecation0.76063521
137MP0000613_abnormal_salivary_gland0.75811279
138MP0005167_abnormal_blood-brain_barrier0.75787522
139MP0005084_abnormal_gallbladder_morpholo0.75767217
140MP0000689_abnormal_spleen_morphology0.75213418
141MP0002090_abnormal_vision0.74934481
142MP0009643_abnormal_urine_homeostasis0.74338814
143MP0001666_abnormal_nutrient_absorption0.74262770
144MP0003566_abnormal_cell_adhesion0.74104507
145MP0000733_abnormal_muscle_development0.73020485
146MP0009278_abnormal_bone_marrow0.72874718
147MP0005410_abnormal_fertilization0.72063831
148MP0003868_abnormal_feces_composition0.71969217
149MP0009384_cardiac_valve_regurgitation0.71784618
150MP0008932_abnormal_embryonic_tissue0.71716903
151MP0000678_abnormal_parathyroid_gland0.70316467
152MP0000609_abnormal_liver_physiology0.70172782
153MP0003567_abnormal_fetal_cardiomyocyte0.70130756
154MP0002084_abnormal_developmental_patter0.70074332
155MP0004782_abnormal_surfactant_physiolog0.69523297
156MP0001851_eye_inflammation0.68272210
157MP0002163_abnormal_gland_morphology0.68131541
158MP0001853_heart_inflammation0.67661913
159MP0000767_abnormal_smooth_muscle0.67623513
160MP0001663_abnormal_digestive_system0.67393638
161MP0002006_tumorigenesis0.67078750
162MP0005076_abnormal_cell_differentiation0.66181146
163MP0003690_abnormal_glial_cell0.65862378
164MP0000598_abnormal_liver_morphology0.64265317
165MP0009250_abnormal_appendicular_skeleto0.63984172
166MP0002933_joint_inflammation0.62395811
167MP0010307_abnormal_tumor_latency0.59694364
168MP0002118_abnormal_lipid_homeostasis0.59642778

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.83453486
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.83453486
3Abnormality of glycolipid metabolism (HP:0010969)4.83453486
4Abnormality of macrophages (HP:0004311)4.17299354
5Male infertility (HP:0003251)4.06754119
6Vacuolated lymphocytes (HP:0001922)3.59927133
7Abnormality of the fingertips (HP:0001211)3.54778783
8Optic neuritis (HP:0100653)3.50578480
9Retrobulbar optic neuritis (HP:0100654)3.50578480
10Stomatitis (HP:0010280)3.49157378
11Recurrent abscess formation (HP:0002722)3.45099143
12Recurrent bacterial skin infections (HP:0005406)3.37743237
13Systemic lupus erythematosus (HP:0002725)3.37462981
14Orchitis (HP:0100796)3.28974892
15Myositis (HP:0100614)3.16858629
16Abnormality of the prostate (HP:0008775)3.05174129
17Mediastinal lymphadenopathy (HP:0100721)2.99694075
18Acute necrotizing encephalopathy (HP:0006965)2.98576954
19Eczematoid dermatitis (HP:0000976)2.95370278
20Rectal prolapse (HP:0002035)2.92771016
21Obstructive lung disease (HP:0006536)2.90781087
22Chronic obstructive pulmonary disease (HP:0006510)2.90781087
23Deep venous thrombosis (HP:0002625)2.90707565
24Gastrointestinal infarctions (HP:0005244)2.88547678
25Recurrent gram-negative bacterial infections (HP:0005420)2.87907625
26Mitochondrial inheritance (HP:0001427)2.84106433
27Increased IgM level (HP:0003496)2.81924582
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78352354
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78352354
30Abnormal mitochondria in muscle tissue (HP:0008316)2.75999716
31Arterial thrombosis (HP:0004420)2.75662421
32Increased cerebral lipofuscin (HP:0011813)2.73172955
33Chromsome breakage (HP:0040012)2.72682338
34Pulmonary fibrosis (HP:0002206)2.71941617
35Nausea (HP:0002018)2.70968975
36Elevated erythrocyte sedimentation rate (HP:0003565)2.68449081
37Reticulocytopenia (HP:0001896)2.68428761
38Loss of speech (HP:0002371)2.67090978
39Progressive neurologic deterioration (HP:0002344)2.62691227
40T lymphocytopenia (HP:0005403)2.61278310
41Acute encephalopathy (HP:0006846)2.60351036
42Shawl scrotum (HP:0000049)2.59722794
43Increased CSF lactate (HP:0002490)2.59281449
44Generalized aminoaciduria (HP:0002909)2.58642010
45Pulmonary embolism (HP:0002204)2.58128146
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57603755
47Thrombophlebitis (HP:0004418)2.53586310
48Renal Fanconi syndrome (HP:0001994)2.51956489
49IgG deficiency (HP:0004315)2.51447350
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49782368
51Ureteral stenosis (HP:0000071)2.47710411
52Lip pit (HP:0100267)2.47413822
53Amyloidosis (HP:0011034)2.46290634
54Thrombocytosis (HP:0001894)2.46093304
55Polycythemia (HP:0001901)2.45943291
56Recurrent fungal infections (HP:0002841)2.44587016
57Pulmonary infiltrates (HP:0002113)2.43506394
58Lipid accumulation in hepatocytes (HP:0006561)2.43305195
59Acute myeloid leukemia (HP:0004808)2.42946756
60Abnormality of T cell number (HP:0011839)2.40007189
61Cortical dysplasia (HP:0002539)2.38820721
62Keratoconjunctivitis sicca (HP:0001097)2.38653280
63Hepatocellular necrosis (HP:0001404)2.38435691
64Increased hepatocellular lipid droplets (HP:0006565)2.38131478
65Progressive macrocephaly (HP:0004481)2.36510425
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.32952080
67Meningitis (HP:0001287)2.32702593
68Hepatic necrosis (HP:0002605)2.31433294
69Polyneuropathy (HP:0001271)2.29005407
70B lymphocytopenia (HP:0010976)2.26180000
71Abnormality of B cell number (HP:0010975)2.25730056
72Cerebral edema (HP:0002181)2.23181226
73Esophageal varix (HP:0002040)2.23055139
74Hepatosplenomegaly (HP:0001433)2.23012380
75Autoimmune thrombocytopenia (HP:0001973)2.22112003
763-Methylglutaconic aciduria (HP:0003535)2.20981786
77Dysostosis multiplex (HP:0000943)2.20628971
78Recurrent skin infections (HP:0001581)2.18861085
79Ureteral obstruction (HP:0006000)2.17692050
80Hemoptysis (HP:0002105)2.17500652
81Birth length less than 3rd percentile (HP:0003561)2.17426067
82Increased serum ferritin (HP:0003281)2.16194453
83Premature ovarian failure (HP:0008209)2.15553332
84Multiple enchondromatosis (HP:0005701)2.14974685
85Petechiae (HP:0000967)2.14607224
86Recurrent viral infections (HP:0004429)2.13968855
87Microretrognathia (HP:0000308)2.13720372
88Gangrene (HP:0100758)2.13368240
89Anorexia (HP:0002039)2.12443198
90Hypergonadotropic hypogonadism (HP:0000815)2.12347672
91Pancreatitis (HP:0001733)2.10277907
92Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09120115
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08193978
94Abnormality of polysaccharide metabolism (HP:0011012)2.08193978
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08193978
96Patellar aplasia (HP:0006443)2.07892611
97Aplastic anemia (HP:0001915)2.07003557
98Exertional dyspnea (HP:0002875)2.05881348
99Aplasia/Hypoplasia of the patella (HP:0006498)2.05572690
100Hematochezia (HP:0002573)2.05216843
101Increased intramyocellular lipid droplets (HP:0012240)2.05192857
102Episodic fever (HP:0001954)2.03664374
103Keratoconjunctivitis (HP:0001096)2.03050901
104Lactic acidosis (HP:0003128)2.02878123
105Insulin resistance (HP:0000855)2.02757986
106Unilateral renal agenesis (HP:0000122)2.01682453
107Abnormality of the pleura (HP:0002103)2.01351629
108Disinhibition (HP:0000734)2.01243335
109Secondary amenorrhea (HP:0000869)2.00496236
110Breast hypoplasia (HP:0003187)2.00107802
111IgM deficiency (HP:0002850)1.99845013
112Malnutrition (HP:0004395)1.99315708
113Combined immunodeficiency (HP:0005387)1.98952162
114Capillary hemangiomas (HP:0005306)1.97937025
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97241616
116Mutism (HP:0002300)1.96721318
117Joint swelling (HP:0001386)1.95959127
118Spontaneous abortion (HP:0005268)1.93514692
119Abnormality of T cells (HP:0002843)1.92355027
120Abnormality of the nasal mucosa (HP:0000433)1.91563307
121Purpura (HP:0000979)1.91335996
122Increased muscle lipid content (HP:0009058)1.90327433
123Abnormality of urine glucose concentration (HP:0011016)1.90148646
124Glycosuria (HP:0003076)1.90148646
125Ectopic kidney (HP:0000086)1.88668745
126Prolonged neonatal jaundice (HP:0006579)1.88515087
127Leukocytosis (HP:0001974)1.87553458
128Lethargy (HP:0001254)1.86980677
129Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86288872
130Abnormal hemoglobin (HP:0011902)1.85566289
131Sparse lateral eyebrow (HP:0005338)1.85546517
132Respiratory failure (HP:0002878)1.84549697
133Myocardial infarction (HP:0001658)1.83758880
134Abnormality of male internal genitalia (HP:0000022)1.83265832
135Camptodactyly of toe (HP:0001836)1.83244480
136Reduced antithrombin III activity (HP:0001976)1.82922398
137Chronic diarrhea (HP:0002028)1.82718497
138Urticaria (HP:0001025)1.82032419
139Myelodysplasia (HP:0002863)1.81097508
140Lymphopenia (HP:0001888)1.80866286
141Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80338067
142Hypochromic anemia (HP:0001931)1.79471406
143Long toe (HP:0010511)1.78881366
144Encephalitis (HP:0002383)1.78846635
145Abnormality of chromosome stability (HP:0003220)1.78373156
146Nasal polyposis (HP:0100582)1.78081752
147Facial hemangioma (HP:0000329)1.77386437
148Abnormality of the intrinsic pathway (HP:0010989)1.76593584
149Blepharitis (HP:0000498)1.76242376
150Hyperammonemia (HP:0001987)1.74869673
151Spontaneous hematomas (HP:0007420)1.74116382
152Chest pain (HP:0100749)1.73662547
153Abnormality of the intervertebral disk (HP:0005108)1.72312160
154Insulin-resistant diabetes mellitus (HP:0000831)1.71319455
155Microcytic anemia (HP:0001935)1.70826739
156Hypoglycemic coma (HP:0001325)1.68421184
157Intrahepatic cholestasis (HP:0001406)1.68322765
158Abnormality of sulfur amino acid metabolism (HP:0004339)1.67950551
159Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66924000
160Abnormality of alanine metabolism (HP:0010916)1.66924000
161Hyperalaninemia (HP:0003348)1.66924000
162Abnormality of the preputium (HP:0100587)1.65523290
163Abnormality of methionine metabolism (HP:0010901)1.64283574
164Epistaxis (HP:0000421)1.63209872
165Vasculitis (HP:0002633)1.62713057
166Chronic bronchitis (HP:0004469)1.61955496
167Glomerulopathy (HP:0100820)1.61715794
168Abnormality of the pericardium (HP:0001697)1.61269251
169Abnormality of monocarboxylic acid metabolism (HP:0010996)1.60588147
170Abnormality of the left ventricular outflow tract (HP:0011103)1.60396573
171Subaortic stenosis (HP:0001682)1.60396573
172Hyperglycemia (HP:0003074)1.60222544
173Aortic dissection (HP:0002647)1.59730237
174Abnormality of pyrimidine metabolism (HP:0004353)1.59291985
175Abnormal platelet function (HP:0011869)1.58248926
176Impaired platelet aggregation (HP:0003540)1.58248926
177Severe combined immunodeficiency (HP:0004430)1.56132419
178Rib fusion (HP:0000902)1.52719461
179Peritonitis (HP:0002586)1.52504292
180Meckel diverticulum (HP:0002245)1.51374021
181Pallor (HP:0000980)1.50763693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.30575143
2TAOK33.73614326
3TXK3.43882511
4EEF2K3.29115471
5STK38L3.07560801
6LATS23.06737100
7MAP3K62.99066803
8CDK82.82097230
9IRAK32.56976049
10VRK22.54900496
11TESK22.48120757
12MATK2.27973758
13CDC72.24677763
14RIPK42.20919444
15TAOK12.17556350
16PLK42.12407431
17GRK72.10458733
18ADRBK22.03124905
19MST41.99730878
20BLK1.97434510
21STK31.96903678
22MAP3K141.93730672
23STK101.91185282
24TRIB31.88153554
25MAP4K11.87652847
26ERBB41.84436099
27MOS1.82099407
28IKBKB1.79027625
29MAP3K121.78807232
30TBK11.78624325
31CDK191.76221011
32NEK21.75724890
33ZAK1.67012640
34IRAK41.58123821
35PIM21.54503674
36TTK1.48642241
37RPS6KA41.44599039
38JAK31.42268103
39DMPK1.41329015
40KDR1.40791044
41KSR21.40159747
42NLK1.39921759
43FGR1.38802182
44CDK91.38347399
45MAPKAPK31.37981000
46TAOK21.36753015
47CSK1.36391229
48PKN21.35199131
49MAP3K131.29707644
50ARAF1.27634523
51ERN11.22397244
52ACVR1B1.20344754
53MELK1.18217896
54TLK11.15967143
55CDK41.15640495
56CHEK21.15432796
57BCKDK1.15189612
58MAP4K21.14244203
59TESK11.13410447
60TNK21.11017025
61LYN1.10679553
62VRK11.10423508
63TGFBR11.07252935
64FES1.04188305
65LRRK21.03528952
66CDK71.00763137
67DYRK30.99188047
68SYK0.98917182
69RPS6KB20.98477233
70MAPK110.97427577
71STK160.96549722
72CSF1R0.96373265
73PINK10.94889350
74MAP3K80.94874998
75RAF10.94291677
76HIPK20.93479585
77TYK20.92514893
78AURKB0.92045708
79MAP2K60.90677436
80SIK10.88186394
81MAP3K100.87604962
82CDK60.87234806
83MAP3K110.87046283
84ZAP700.83496367
85DAPK30.81087014
86PRKD20.80490475
87BUB10.78677553
88CSNK1G30.78155702
89LCK0.76333795
90MYLK0.75403288
91CDK120.75373640
92STK240.75347598
93NEK90.74019429
94TYRO30.72546750
95ABL20.71713204
96NUAK10.71074119
97NME20.70707243
98GRK10.70408924
99BRAF0.70313206
100MAP3K50.69993462
101TIE10.69849738
102MAP2K30.69722615
103TGFBR20.69716704
104BMPR1B0.69442817
105DAPK10.67085276
106PIM10.65686708
107SRPK10.65040719
108PAK40.64910983
109FGFR40.64690362
110EIF2AK30.64519436
111PDK20.61786186
112ITK0.60974649
113BMPR20.59751168
114TEC0.58968144
115JAK20.58770557
116PRKCQ0.58545705
117PRKAA20.58028956
118CSNK1A1L0.57818957
119OXSR10.56513550
120PLK10.56399951
121LIMK10.53670763
122ILK0.52126889
123DYRK20.52023939
124IRAK10.51414766
125CSNK1G20.51215793
126PTK60.49622485
127PASK0.49407821
128CHUK0.47952946
129PBK0.47600664
130STK380.47105035
131HCK0.46120856
132CDC42BPA0.45729699
133PRKG20.45658739
134GRK60.45598759
135MARK20.45076246
136MAP3K10.44020564
137CSNK1G10.43081497
138RET0.42554888
139TTN0.42489262
140RPS6KA50.41675212
141KIT0.40966326
142NME10.40103394
143MAP2K20.39675281
144ABL10.38708845
145TRPM70.38312536
146ATM0.38209614
147IRAK20.37831073
148CHEK10.37811910
149CSNK2A10.36545732
150MAP2K70.35399487
151DAPK20.33907433
152WNK30.33526145
153MARK30.32018395
154PRKAA10.31289610
155FLT30.30951511
156EPHB20.30811355
157PRKCD0.30657710
158MUSK0.30308511
159BTK0.29351078
160MAP3K70.27635977
161PRKD30.27370393
162IKBKE0.27267576
163ATR0.24064832
164AURKA0.23026704
165MAP3K30.22610715
166JAK10.21383624

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.05593033
2Proteasome_Homo sapiens_hsa030502.88662131
3Type I diabetes mellitus_Homo sapiens_hsa049402.68910189
4Rheumatoid arthritis_Homo sapiens_hsa053232.58022116
5Cell cycle_Homo sapiens_hsa041102.43150541
6Oxidative phosphorylation_Homo sapiens_hsa001902.32784788
7DNA replication_Homo sapiens_hsa030302.31361105
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25134914
9RNA degradation_Homo sapiens_hsa030182.19611137
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06719744
11Antigen processing and presentation_Homo sapiens_hsa046122.05219002
12Ribosome_Homo sapiens_hsa030101.96951234
13Basal transcription factors_Homo sapiens_hsa030221.85130877
14One carbon pool by folate_Homo sapiens_hsa006701.79809177
15Parkinsons disease_Homo sapiens_hsa050121.79636127
16Base excision repair_Homo sapiens_hsa034101.79259661
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.72601384
18Folate biosynthesis_Homo sapiens_hsa007901.68652802
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61939380
20Homologous recombination_Homo sapiens_hsa034401.56170622
21Lysosome_Homo sapiens_hsa041421.55578438
22Pancreatic cancer_Homo sapiens_hsa052121.48216346
23Other glycan degradation_Homo sapiens_hsa005111.47350644
24Autoimmune thyroid disease_Homo sapiens_hsa053201.46314281
25Ovarian steroidogenesis_Homo sapiens_hsa049131.40973449
26TGF-beta signaling pathway_Homo sapiens_hsa043501.40777109
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38432915
28Legionellosis_Homo sapiens_hsa051341.37549072
29Mismatch repair_Homo sapiens_hsa034301.36962882
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36221051
31Tuberculosis_Homo sapiens_hsa051521.36157703
32Small cell lung cancer_Homo sapiens_hsa052221.35081852
33Primary immunodeficiency_Homo sapiens_hsa053401.34860737
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34395316
35Nucleotide excision repair_Homo sapiens_hsa034201.32877870
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.31531631
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.31105076
38Pertussis_Homo sapiens_hsa051331.29936320
39Viral myocarditis_Homo sapiens_hsa054161.29546967
40p53 signaling pathway_Homo sapiens_hsa041151.28866563
41Glutathione metabolism_Homo sapiens_hsa004801.26391469
42Asthma_Homo sapiens_hsa053101.25437000
43Fatty acid degradation_Homo sapiens_hsa000711.25116952
44Protein export_Homo sapiens_hsa030601.24797740
45RNA transport_Homo sapiens_hsa030131.22599824
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21068390
47Fanconi anemia pathway_Homo sapiens_hsa034601.19947153
48Selenocompound metabolism_Homo sapiens_hsa004501.19776873
49Osteoclast differentiation_Homo sapiens_hsa043801.19306039
50Sulfur relay system_Homo sapiens_hsa041221.18605761
51Adherens junction_Homo sapiens_hsa045201.18029570
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16641193
53Vitamin B6 metabolism_Homo sapiens_hsa007501.15961720
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.15507552
55Sulfur metabolism_Homo sapiens_hsa009201.15297545
56Arginine biosynthesis_Homo sapiens_hsa002201.10673631
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09750322
58African trypanosomiasis_Homo sapiens_hsa051431.09566281
59MicroRNAs in cancer_Homo sapiens_hsa052061.08678308
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08511091
61Primary bile acid biosynthesis_Homo sapiens_hsa001201.07560855
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05194250
63Alzheimers disease_Homo sapiens_hsa050101.04173086
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03254927
65Collecting duct acid secretion_Homo sapiens_hsa049661.02164875
66Salmonella infection_Homo sapiens_hsa051321.01709766
67Caffeine metabolism_Homo sapiens_hsa002321.01384240
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00741634
69RNA polymerase_Homo sapiens_hsa030201.00174874
70Lysine degradation_Homo sapiens_hsa003100.99819899
71Herpes simplex infection_Homo sapiens_hsa051680.98351801
72Thyroid cancer_Homo sapiens_hsa052160.98168239
73Pyrimidine metabolism_Homo sapiens_hsa002400.97749897
74Linoleic acid metabolism_Homo sapiens_hsa005910.97544613
75Malaria_Homo sapiens_hsa051440.96412236
76Non-homologous end-joining_Homo sapiens_hsa034500.96231202
77Phagosome_Homo sapiens_hsa041450.95767106
78Bladder cancer_Homo sapiens_hsa052190.95699614
79Tryptophan metabolism_Homo sapiens_hsa003800.94520564
80Influenza A_Homo sapiens_hsa051640.93547279
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93189282
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93102011
83beta-Alanine metabolism_Homo sapiens_hsa004100.90866554
84Propanoate metabolism_Homo sapiens_hsa006400.90067822
85Notch signaling pathway_Homo sapiens_hsa043300.89678165
86Chronic myeloid leukemia_Homo sapiens_hsa052200.89268161
87Huntingtons disease_Homo sapiens_hsa050160.89261352
88Allograft rejection_Homo sapiens_hsa053300.89005550
89Fatty acid elongation_Homo sapiens_hsa000620.88939573
90T cell receptor signaling pathway_Homo sapiens_hsa046600.85423729
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82537861
92Circadian rhythm_Homo sapiens_hsa047100.82190442
93Prolactin signaling pathway_Homo sapiens_hsa049170.82015628
94HTLV-I infection_Homo sapiens_hsa051660.81753695
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.81384917
96Hematopoietic cell lineage_Homo sapiens_hsa046400.77899010
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76884419
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76595669
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76365997
100Arginine and proline metabolism_Homo sapiens_hsa003300.75601867
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.75385525
102Toxoplasmosis_Homo sapiens_hsa051450.74096373
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73933449
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73659969
105Prostate cancer_Homo sapiens_hsa052150.72411873
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72367071
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71963632
108Colorectal cancer_Homo sapiens_hsa052100.71841368
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69946766
110Chemical carcinogenesis_Homo sapiens_hsa052040.68792664
111Hepatitis B_Homo sapiens_hsa051610.67082239
112Galactose metabolism_Homo sapiens_hsa000520.66596917
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.65743063
114Complement and coagulation cascades_Homo sapiens_hsa046100.65462713
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65335709
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64083240
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63684040
118Spliceosome_Homo sapiens_hsa030400.63265453
119Hippo signaling pathway_Homo sapiens_hsa043900.63058981
120Measles_Homo sapiens_hsa051620.62843682
121Biosynthesis of amino acids_Homo sapiens_hsa012300.61993097
122Shigellosis_Homo sapiens_hsa051310.61064180
123TNF signaling pathway_Homo sapiens_hsa046680.60959865
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60811811
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.60380388
126Leishmaniasis_Homo sapiens_hsa051400.59952536
127Arachidonic acid metabolism_Homo sapiens_hsa005900.59840065
128Staphylococcus aureus infection_Homo sapiens_hsa051500.57347082
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57186580
130Epstein-Barr virus infection_Homo sapiens_hsa051690.56054866
131Peroxisome_Homo sapiens_hsa041460.56034138
132Acute myeloid leukemia_Homo sapiens_hsa052210.55562062
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.55401757
134VEGF signaling pathway_Homo sapiens_hsa043700.54688902
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54056621
136Systemic lupus erythematosus_Homo sapiens_hsa053220.53742702
137Non-small cell lung cancer_Homo sapiens_hsa052230.53584128
138FoxO signaling pathway_Homo sapiens_hsa040680.53354341
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52871374
140Retinol metabolism_Homo sapiens_hsa008300.51591297
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49956119
142Fat digestion and absorption_Homo sapiens_hsa049750.49868855
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48532729
144Histidine metabolism_Homo sapiens_hsa003400.48198861
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48058707
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47436875
147mTOR signaling pathway_Homo sapiens_hsa041500.46135858
148PPAR signaling pathway_Homo sapiens_hsa033200.45887182
149Renin-angiotensin system_Homo sapiens_hsa046140.45180995
150Endometrial cancer_Homo sapiens_hsa052130.44056929
151Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43818512
152Pentose phosphate pathway_Homo sapiens_hsa000300.43774223
153Pyruvate metabolism_Homo sapiens_hsa006200.43140871
154Metabolic pathways_Homo sapiens_hsa011000.42929963
155Mineral absorption_Homo sapiens_hsa049780.41544470
156Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39514749
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36986607
158Chemokine signaling pathway_Homo sapiens_hsa040620.35564247
159Fructose and mannose metabolism_Homo sapiens_hsa000510.34883209

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »